CN104519903A - Hgh-xten融合蛋白及其在治疗生长激素缺乏中的用途 - Google Patents

Hgh-xten融合蛋白及其在治疗生长激素缺乏中的用途 Download PDF

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Publication number
CN104519903A
CN104519903A CN201380041556.9A CN201380041556A CN104519903A CN 104519903 A CN104519903 A CN 104519903A CN 201380041556 A CN201380041556 A CN 201380041556A CN 104519903 A CN104519903 A CN 104519903A
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CN
China
Prior art keywords
hgh
xten
days
agent
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380041556.9A
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English (en)
Chinese (zh)
Inventor
J·L·克莱兰
乔治·M·布莱特
埃里克·汉弗里斯
V·谢尔恩伯杰
J·西尔弗曼
W·P·施泰姆尔
王家威
N·吉西格
B·斯平克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amunix Pharmaceuticals Inc
Original Assignee
Amunix Operating Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amunix Operating Inc filed Critical Amunix Operating Inc
Priority to CN201710596161.5A priority Critical patent/CN107320719A/zh
Publication of CN104519903A publication Critical patent/CN104519903A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380041556.9A 2012-06-05 2013-03-14 Hgh-xten融合蛋白及其在治疗生长激素缺乏中的用途 Pending CN104519903A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710596161.5A CN107320719A (zh) 2012-06-05 2013-03-14 Hgh‑xten融合蛋白及其在治疗生长激素缺乏中的用途

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261689390P 2012-06-05 2012-06-05
US61/689,390 2012-06-05
US201261663475P 2012-06-22 2012-06-22
US61/663,475 2012-06-22
US201361763753P 2013-02-12 2013-02-12
US61/763,753 2013-02-12
PCT/US2013/031673 WO2013184216A1 (en) 2012-06-05 2013-03-14 Hgh-xten fusion protein and its use in the treatment of growth hormone deficiency

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710596161.5A Division CN107320719A (zh) 2012-06-05 2013-03-14 Hgh‑xten融合蛋白及其在治疗生长激素缺乏中的用途

Publications (1)

Publication Number Publication Date
CN104519903A true CN104519903A (zh) 2015-04-15

Family

ID=47998551

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201710596161.5A Withdrawn CN107320719A (zh) 2012-06-05 2013-03-14 Hgh‑xten融合蛋白及其在治疗生长激素缺乏中的用途
CN201380041556.9A Pending CN104519903A (zh) 2012-06-05 2013-03-14 Hgh-xten融合蛋白及其在治疗生长激素缺乏中的用途

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201710596161.5A Withdrawn CN107320719A (zh) 2012-06-05 2013-03-14 Hgh‑xten融合蛋白及其在治疗生长激素缺乏中的用途

Country Status (17)

Country Link
US (2) US20140162949A1 (enExample)
EP (1) EP2858664B1 (enExample)
JP (2) JP2015520188A (enExample)
KR (1) KR20150021072A (enExample)
CN (2) CN107320719A (enExample)
AU (1) AU2013272220A1 (enExample)
BR (1) BR112014030404A2 (enExample)
CA (1) CA2875827A1 (enExample)
DK (1) DK2858664T3 (enExample)
ES (1) ES2733220T3 (enExample)
HK (1) HK1208629A1 (enExample)
IL (1) IL236070A0 (enExample)
MX (1) MX2014014927A (enExample)
NZ (1) NZ702557A (enExample)
PH (1) PH12014502738A1 (enExample)
SG (1) SG11201408152VA (enExample)
WO (1) WO2013184216A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109152816A (zh) * 2016-02-17 2019-01-04 株式会社吉耐森 用于治疗生长激素缺乏症的包含重组hgh的药物组合物
CN116003632A (zh) * 2022-12-07 2023-04-25 北京大学 长效缓释型人重组生长激素融合蛋白及其药物组合物和应用

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US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
EP3178835B1 (en) 2009-02-03 2019-04-10 Amunix Pharmaceuticals, Inc. Extended recombinant polypeptides and compositions comprising same
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
US20160158321A1 (en) * 2013-03-11 2016-06-09 Amunix Operting Inc. Treatment of pediatric growth hormone deficiency with human growth hormone analogues
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
WO2017136583A1 (en) 2016-02-02 2017-08-10 Versartis, Inc. Growth hormone treatment adherence system
WO2017142331A1 (en) * 2016-02-17 2017-08-24 Genexine, Inc. Pharmaceutical composition comprising recombinant hgh for the treatment of growth hormone deficiency
US20200000884A1 (en) * 2016-07-27 2020-01-02 Amunix Pharmaceuticals, Inc. Treatment of adult growth hormone deficiency with human growth hormone analogues
JOP20190019A1 (ar) 2016-08-30 2019-02-12 Genexine Inc تركيبة صيدلانية لعلاج نقص في هرمون نمو يحتوي على بروتين اندماجي لهرمون نمو بشري (hGH)
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
AU2018393111B2 (en) 2017-12-21 2025-07-10 Amunix Pharmaceuticals, Inc. Release segments and binding compositions comprising same
CA3100035A1 (en) 2018-08-27 2020-03-05 Regeneron Pharmaceuticals, Inc. Use of raman spectroscopy in downstream purification
WO2021136223A1 (en) 2019-12-31 2021-07-08 Beijing Ql Biopharmaceutical Co., Ltd. Fusion proteins of glp-1 and gdf15 and conjugates thereof
CN113728013B (zh) 2020-01-11 2022-06-14 北京质肽生物医药科技有限公司 Glp-1和fgf21的融合蛋白的缀合物
KR20230083294A (ko) 2020-09-30 2023-06-09 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 폴리펩타이드 접합체 및 사용 방법
CN116554343B (zh) * 2022-01-30 2024-07-12 领诺(上海)医药科技有限公司 一种长效重组人生长激素及其应用
CA3252113A1 (en) 2022-03-30 2023-10-05 Beijing Ql Biopharmaceutical Co., Ltd. Liquid pharmaceutical compositions of polypeptide conjugates and their methods of use

Citations (1)

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WO2010091122A1 (en) * 2009-02-03 2010-08-12 Amunix, Inc. Extended recombinant polypeptides and compositions comprising same

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US4898830A (en) 1979-07-05 1990-02-06 Genentech, Inc. Human growth hormone DNA
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
EP0983303B1 (en) 1997-05-21 2006-03-08 Biovation Limited Method for the production of non-immunogenic proteins
US6406632B1 (en) 1998-04-03 2002-06-18 Symyx Technologies, Inc. Rapid characterization of polymers
GB9815157D0 (en) 1998-07-13 1998-09-09 Metron Designs Ltd High resolution pulse width setting from relatively low frequency clocks
US20030228309A1 (en) 2000-11-08 2003-12-11 Theodora Salcedo Antibodies that immunospecifically bind to TRAIL receptors
WO2002079415A2 (en) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
US7294513B2 (en) 2002-07-24 2007-11-13 Wyatt Technology Corporation Method and apparatus for characterizing solutions of small particles
US8703717B2 (en) * 2009-02-03 2014-04-22 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
US8680050B2 (en) * 2009-02-03 2014-03-25 Amunix Operating Inc. Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
CA2764105A1 (en) 2009-06-08 2010-12-16 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same

Patent Citations (1)

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WO2010091122A1 (en) * 2009-02-03 2010-08-12 Amunix, Inc. Extended recombinant polypeptides and compositions comprising same

Non-Patent Citations (2)

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Title
CLELAND JL ET AL.: "A novel human growth hormone XTEN construct (VRS-317) for monthly administration", 《ENDOCRINE JOURNAL》 *
CLELAND JL ET AL.: "A novel human growth hormone XTEN construct (VRS-317) for once-a-month subcutaneous administration in a phase 1a study of growth hormone deficient adults", 《ENDOCR REV》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109152816A (zh) * 2016-02-17 2019-01-04 株式会社吉耐森 用于治疗生长激素缺乏症的包含重组hgh的药物组合物
CN109152816B (zh) * 2016-02-17 2022-08-16 株式会社吉耐森 用于治疗生长激素缺乏症的包含重组hgh的药物组合物
CN116003632A (zh) * 2022-12-07 2023-04-25 北京大学 长效缓释型人重组生长激素融合蛋白及其药物组合物和应用
WO2024119791A1 (zh) * 2022-12-07 2024-06-13 北京大学 长效缓释型人重组生长激素融合蛋白及其药物组合物和应用

Also Published As

Publication number Publication date
PH12014502738A1 (en) 2015-02-02
MX2014014927A (es) 2015-05-15
JP2015520188A (ja) 2015-07-16
SG11201408152VA (en) 2015-01-29
CN107320719A (zh) 2017-11-07
JP2017125051A (ja) 2017-07-20
US20140162949A1 (en) 2014-06-12
NZ702557A (en) 2017-06-30
IL236070A0 (en) 2015-01-29
HK1208629A1 (en) 2016-03-11
AU2013272220A1 (en) 2015-01-15
CA2875827A1 (en) 2013-12-12
KR20150021072A (ko) 2015-02-27
BR112014030404A2 (pt) 2017-06-27
EP2858664A1 (en) 2015-04-15
US20180051063A1 (en) 2018-02-22
ES2733220T3 (es) 2019-11-28
EP2858664B1 (en) 2019-05-08
WO2013184216A1 (en) 2013-12-12
DK2858664T3 (da) 2019-07-08

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Application publication date: 20150415