KR20140100476A - 헤테로아릴 하이드록삼산 유도체 및 바이러스성 질환을 치료, 개선 또는 예방하는데 있어서의 이들의 용도 - Google Patents

헤테로아릴 하이드록삼산 유도체 및 바이러스성 질환을 치료, 개선 또는 예방하는데 있어서의 이들의 용도 Download PDF

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Publication number
KR20140100476A
KR20140100476A KR1020147013723A KR20147013723A KR20140100476A KR 20140100476 A KR20140100476 A KR 20140100476A KR 1020147013723 A KR1020147013723 A KR 1020147013723A KR 20147013723 A KR20147013723 A KR 20147013723A KR 20140100476 A KR20140100476 A KR 20140100476A
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South Korea
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alkyl
compound
optionally substituted
aryl
cycloalkyl
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Korean (ko)
Inventor
디르크 클라센-호우벤
안드레아 볼케르슈토르퍼
올리버 슈졸라
마크 스미쓰
숭사우 소
스테판 쿠삭
티에리 랑제
브뤼노 지에쓸렌
크리스토프 모리스
셀린느 미사우트시몬
끌로에 주비타
Original Assignee
에프. 호프만-라 로슈 아게
사피라 파르마슈티칼즈 게엠베하
유럽피안 몰레큘러 바이올로지 래보러토리
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Publication of KR20140100476A publication Critical patent/KR20140100476A/ko
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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147013723A 2011-10-21 2012-10-19 헤테로아릴 하이드록삼산 유도체 및 바이러스성 질환을 치료, 개선 또는 예방하는데 있어서의 이들의 용도 Withdrawn KR20140100476A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161550045P 2011-10-21 2011-10-21
US61/550,045 2011-10-21
PCT/EP2012/070757 WO2013057251A2 (en) 2011-10-21 2012-10-19 Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease

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US (2) US20130102600A1 (enExample)
EP (1) EP2776396A2 (enExample)
JP (1) JP6047168B2 (enExample)
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CN (1) CN103958475B (enExample)
BR (1) BR112014001369A2 (enExample)
CA (1) CA2852750A1 (enExample)
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CN103958475B (zh) 2015-11-25
HK1197059A1 (en) 2015-01-02
RU2014120421A (ru) 2015-11-27
MX2014003803A (es) 2015-03-23
EP2776396A2 (en) 2014-09-17
BR112014001369A2 (pt) 2017-01-10
CA2852750A1 (en) 2013-04-25
CN103958475A (zh) 2014-07-30
US20160297763A1 (en) 2016-10-13
WO2013057251A2 (en) 2013-04-25
JP6047168B2 (ja) 2016-12-21
WO2013057251A3 (en) 2013-06-06
HK1199640A1 (en) 2015-07-10
JP2014530837A (ja) 2014-11-20
US20130102600A1 (en) 2013-04-25

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