KR20140081272A - Retinol cosmetic composition of low irritation - Google Patents

Abstract

The present invention relates to a cosmetic composition having retinol to improve frilly skin which contains 1-30 wt% of the total weight percentage of an anti-inflammatory complex as an abirritant. The water-in-oil cosmetic composition especially contains high concentration retinol so that the improvement effectiveness for frilly skin is greatly enhanced and obtains an excellent hypo-allergenic effect by providing an effect of easing skin stimulation. In addition, the frilly skin is improved and skin stimulation is eased by the use of hypo-allergenic cosmetic composition having retinol.

Description

Retinol cosmetic composition of low irritation < RTI ID = 0.0 >

TECHNICAL FIELD The present invention relates to a retinol-containing cosmetic composition for improving wrinkled skin, and more particularly, to a retinol-containing hypoallergenic cosmetic composition containing a retinol at a high concentration, which is excellent in the effect of improving wrinkles, while relieving irritation to the skin.

Retinol is a type of vitamin A and is also known as pure vitamin. The skin's epidermal cells play an important role in maintaining the original function. Details are also known as pure vitamin A under the chemical name of vitamin A1. It is present in the intestinal mucosa cells of animals and is abundant in greenish-yellow plants. It is transformed into retinoic acid, an active form, and it is known that epidermal cells play an important role in maintaining original function. In addition, among the cell nuclei present in skin cells, DNA promotes cell differentiation by expressing RNA, promotes biosynthesis of collagen, which is a light protein present as a fibrous solid between the cells of an animal, and elastin composed of elastic fibers, It is known to have an efficacy to reduce skin elasticity.

Retinol as a cosmetic composition has an effect of promoting the collagen synthesis of the skin and promoting the turnover of the stratum corneum to promote the production of cells. As the amount of retinol increases, the efficacy of the retinol increases greatly. However, And the retinol itself is very unstable and has a problem that it is denatured or decomposed with time to decrease its activity and its effect is reduced, so that use of retinol in cosmetics is extremely limited.

Therefore, there have been many attempts to solve the above-mentioned problems of retinol by adding other ingredients together with retinol to cosmetics. In the case of adding other substances to mitigate the stimulation of retinol, (10-2005-0121397) that inhibits the production of inflammation and inhibits skin irritation by inhibiting the production of PGE2, an Eicosanoid, which induces inflammation of the Cyclooxygenase pathway, and prevents skin irritation and inflammation (Korean Patent Laid-Open No. 10-2005-0080480), a nanoliposome stabilized by incorporating the Aspergillus oryzae extract (Korean Patent Laid-Open No. 10-2008-0062224), a mung bean that alleviates skin irritation caused by retinol (Korean Patent Publication No. 10-2003-0042527) inhibits the growth of retinol and acne-forming strains and has an anti-inflammatory effect Phytosphingosine and uricopteran extracts (Korean Patent Publication 10-2000-0065305), intermediates for important seraide biosynthesis as an intercellular lipid constituent of the stratum corneum, increased skin irritation, transdermal water loss and inflammation caused by retinoids A fatty acid or C10-40 isoalkyl cholesterol ester corresponding to a ligand of peroxisome proliferator-activated receptor alpha, which can effectively reduce cytokine, phytosteryl / isostearyl / cetyl Stearyl / behenyl dimer dirinoleate and a lipid complex of canola oil (Korean Patent Publication 10-2010-0023246).

However, skin irritation caused by retinol is not merely a form but a stimulus such as itching, stinging, burning, various inflammatory stimuli such as erythema and edema, The use thereof is limited because the reaction occurs, and there is also a problem that it is not enough to simply alleviate the irritation by using one anti-inflammatory raw material.

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a hypoallergenic cosmetic composition containing retinol at a high concentration and alleviating skin irritation to improve wrinkles.

In order to achieve the above object, the present invention provides a cosmetic composition for improving wrinkles containing retinol, wherein the antiinflammable complex as a stimulant is contained in an amount of 1 to 30% by weight based on the total weight of the composition ≪ / RTI >

Preferably, the cosmetic composition of the present invention comprises 1 to 10% by weight of an emulsifier, 10 to 40% by weight of an oil phase, and 40 to 80% by weight of an aqueous phase, in addition to the anti-salt complex.

Preferably, the cosmetic composition of the present invention is characterized by being in a water-in-oil type.

Preferably, the cosmetic composition of the present invention is characterized by containing the retinol in an amount of 3000 to 6000 IU.

Preferably, the anti-inflammatory complex is a mixture of two or more ingredients selected from the group consisting of nutmeg extract, alanyl glutamine, acetyltetapeptide-15, arnica flower extract, algae extract, panthenol and beta-glucan together with burdock seed extract Can be used. That is, the cosmetic composition of the present invention preferably contains a burdock seed extract as a anti-inflammatory complex and, in addition, a mixture of two or more of the anti-inflammatory complexes is preferably used.

The present invention finds that the efficacy of retinol on skin increases proportionally up to about 6000 IU and does not produce a large difference above 6000 IU (S. Kang et al., J. Investigative Dermatology , 105, 549-556, 1995), and to provide a cosmetic composition which maximizes the effect on the skin by setting 5000 IU as an amount that can increase the efficacy of retinol while minimizing skin irritation. However, since cosmetic compositions with a retinol concentration of 2500 IU or more also give a large stimulus to the skin, a variety of anti-inflammatory agents have been studied in order to reduce the irritation to the skin. Essential inclusion of burdock seed extract and other anti- The present inventors have found that the cosmetic composition containing the present invention has a great effect on skin hypoactivity, and particularly preferably, by confirming that a water-in-oil type cosmetic composition can significantly reduce skin irritation compared to a conventional underwater type cosmetic composition, .

In the retinol-containing hypoallergenic composition of the present invention, the retinol contained as an active ingredient for improving wrinkles is used in an amount of 3000 to 6000 IU (International Unit). When the retinol is used in an amount less than 3000 IU, It is not economical in terms of cost because it is not proportional to the content when it is used in an amount exceeding 6000 IU.

The anti-inflammatory complex used in the retinol-containing hypoallergenic cosmetic composition of the present invention comprises, in combination with burdock seed extract, a nutmeg extract, alanyl glutamine, acetyltetapeptide-15, arnica flower extract, algae extract, panthenol and beta-glucan May be used in combination. However, the present invention is not limited to this, and other anti-inflammatory ingredients known to have anti-inflammatory effects together with the anti-inflammatory complex may be used in combination. The anti-inflammatory complex is used in an amount of 1 to 30% by weight, preferably 3 to 15% by weight based on the total weight of the composition. When the anti-inflammatory complex is used in an amount of less than 1% by weight based on the total weight of the composition, the anti-inflammatory effect is insufficient and irritation is largely caused. When the anti-inflammatory complex is used in an amount exceeding 30% by weight, There is a problem that the reality is not good.

The anti-inflammatory complex may be used in a weight ratio of 1: 1 to 1:20, other than the burdock seed extract and the anti-inflammatory complex. In this case, when the burdock seed extract is used at a weight ratio lower than the above ratio to the other anti-inflammatory complexes or when the weight ratio is higher than the above ratio, the skin irritation mitigating effect is lowered.

The emulsifier used in the hypothetical retinol cosmetic composition of the present invention greatly affects the size of emulsified particles, stability of emulsification, feeling of use and the like depending on the kind and content thereof. The content of the emulsifier influences the stability of the emulsion, and it is preferable to use 1 to 10% by weight based on the total weight of the composition. When the amount of the emulsifier is less than 1% by weight, there is a problem that the emulsion is separated from the stability with the elapse of time. When the amount is more than 10% by weight, the stability is improved but the feeling of use is greatly deteriorated. As the emulsifier, one or more synthetic surfactants and natural surfactants such as an anionic surfactant, a cationic surfactant, an amphoteric surfactant and a nonionic surfactant can be used. In the present invention, a nonionic surfactant is mainly used use.

The nonionic surfactant comprises dimethicone copolyol as an organically modified organopolysiloxane. Such materials include polyether side chains, such as polyether siloxanes modified to include polyether chains including polyether oxide chains, polypropylene oxide chains, mixtures of such chains, and moieties derived from both ethylene oxide and propylene oxide to be. Other examples include alkyl-modified dimethicone copolyols, i.e., compounds comprising a C2-C30 pendant side chain. Nonlimiting examples of dimethicone copolyols and other silicone surfactants useful as surfactants in the present invention include polydimethylsiloxane polyether copolymers with pendant polyethylene oxide side chains, polydimethylsiloxane polyether copolymers with pendant polypropylene oxide side chains , Polydimethylsiloxane polyether copolymers with pendant mixed polyethylene oxide and polypropylene oxide side chains, polydimethylsiloxane polyether copolymers with pendant mixed poly (ethylene) (propylene) oxide side chains, polydimethylsiloxane polyethers with pendant organic betaine side chains Polydimethylsiloxane polyether copolymers with pendant quaternary ammonium side chains, and polydimethylsiloxane polyether copolymers with pendant C2-C30 linear, branched, or cyclic siloxane polyether copolymers with pendant carboxylate side chains, It includes a further modification of the copolymer containing the alkyl moiety. Other non-limiting examples of dimethicone copolyols include lauryl dimethicone copolyol, lauryl polydimethylsiloxy ethyl dimethicone copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethicone copolyol amine, Dimethicone copolyol propionate, dimethicone copolyol propionate, dimethicone copolyol propionate, dimethicone copolyol propionate, dimethicone copolyol propionate, dimethicone copolyol propionate, Dimethicone copolyol stearate is also included.

 Examples of the anionic surfactant include sodium laurate, sodium palmitate, sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine salt of POE-lauryl sulfate, sodium POE-lauryl sulfate, sodium lauroyl sarcoate Sodium n-myristoyl-N-methyl-taurine, sodium N-cocoyl-N-methyl taurate, sodium lauroylmethyl taurate, sodium POE-oleyl ether phosphate, sodium POE-stearyl ether phosphate , Sodium di-2-ethylhexyl sulfosuccinate, sodium monooroyl monoethanolamido polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, sodium linear dodecylsulfonate, sodium linear Monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-glutamate, cured coconut oil fatty acid ester, PO Alkyl ether carboxylates, POE-alkylaryl ether carboxylates,? -Olefin sulfonates, higher fatty acid ester sulfonates, secondary alcohol sulfate ester salts, higher fatty acid alkylol amide sulfate ester salts, sodium lauro Monoethanolamidosuccinate, N-palmitoyl aspartic acid di-triethanolamine salt, sodium caseinate and the like. Examples of the anionic surfactant include stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, distearyldimethyl-ammonium (N, N'-dimethyl-3,5-methylenepiperidinium) chloride, cetylpyridinium chloride, alkyltetrammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorpholinium salts, POE -Alkylamines, alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzene Thionyl chloride, and the like. Examples of amphoteric surfactants include sodium 2-undecyl-N, N, N '- (hydroxyethylcarboxymethyl) -2-imidazoline, disodium 2-cocoyl- 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amide betaine, And sulphobetaine.

The retinol-containing hypoallergenic cosmetic composition of the present invention is preferably a water-in-oil type. Accordingly, the retinol-containing hypoallergenic cosmetic composition of the present invention comprises an oil phase, and the oil phase is mainly composed of an oil, which may be divided into a silicone, an ester, a hydrocarbon, a vegetable oil and a fat, And it is preferably used in an amount of 10 to 40% by weight based on the total weight. When the oil phase is used in an amount of less than 10% by weight, it is not easy to produce cosmetics of the water-in-oil type, and when it is used in an amount exceeding 40% by weight, the cosmetic preparation is easy to use.

The kind of the silicone oil is not particularly limited, and a typical silicone oil used for a cosmetic composition can be used. Specific examples thereof include cyclopentasiloxane, cyclohexasiloxane, cycloheptasiloxane, cyclomethicone, cyclophenylmethicones, cyclotetrasiloxane, cyclotrisiloxane, dimethicone, caprylimethicone, caprylyltrimethicone, But are not limited to, chicone, cetearyl methicone, hexadecyl methicone, hexyl methicone, lauryl methicone, myristyl methicone, phenyl methicone, stearyl methicone, scaryl dimethicone, trifluoropropyl methicone, , Silicone-based fluid oils such as dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, methyltrimethicone and phenyltrimethicone, or silicone-based crosspolymers dispersed in the oil, such as cetearyl dimethicone crosspolymer, Dimethyl dimethicone crosspolymer, dimethicone cross polymer, dimethicone cross polymer-3, dimethicone / phage- 10 crosspolymer, dimethicone / phage-10/15 crosspolymer, dimethicone / phage-15 crosspolymer, dimethicone / phenylvinyl dimethicone crosspolymer, dimethicone / polyglyceryl-3 crosspolymer, dimethicone / Silane crosspolymer, diphenyl dimethicone cross polymer, lauryl dimethicone-15 cross polymer, lauryl dimethicone / polyglycerin-3 A cross-polymer, a vinyl dimethicone / lauryl dimethicone crosspolymer, etc. may be used alone or in combination of two or more. In addition, the non-silicone oils are not particularly limited in their kind, and conventional oils used in cosmetic compositions can be used. Specific examples include ascorbyl palmitate, ascorbylnolate, ascorbyl stearate, distearylate, benzyl benzoate, benzyl laurate, butylene glycol dicaprylate / dicaprate, butylene glycol diisononanoate, But are not limited to, glycol laurate, butylene glycol stearate, butyl isostearate, cetearyl isonanoate, cetearyl nanoate, cetyl caprylate, cetyl ethyl hexanoate, cetylisononanoate, But are not limited to, propylate / caprate, ethylhexylisononanoate, ethylhexyl isosateate, ethylhexyl laurate, hexyl laurate, octyldodecyl isostearate, isopropyl isostearate, isostearyl isonano Octadecyl ether, isostearyl isostearate, isocetyl ethyl hexanoate, neopentyl glycol dicaprate, neopentyl glycol Di-ethyl hexanoate, neopentyl glycol diimide sono nano benzoate, neopentyl glycol isostearate, penta EPO ritil stearate, penta EPO ritil tetraethyl hexanoate esters of oleate, etc. triethyl hexamethylene elderly and the like; Hydrocarbons such as liquid paraffin (liquid paraffin, mineral oil), paraffin, vaseline, microcrystalline wax, and squalene; Corn oil, corn oil, safflower oil, soybean oil, rapeseed oil, macanadia nut oil, jojoba oil, cacao butter, palm oil, wheat germ oil, wheat germ oil, rosehip oil, shea butter, almond oil, olive oil, Vegetable oils such as oils, palm kernel oils and coconut oils; C8-12 acidic triglyceride, C12-18 acid triglyceride, caprylic / capric / triglyceride, caprylic / capric / lauric triglyceride, C10-40 isoalkyl acid triglyceride, C10-18 triglyceride , Glyceryl triacetyl hydroxystearate, soybean glyceride, tribehenin, tricaprin, triethylhexanone, triheptanoin, triisostearin, tripalmitin, tristearin, etc., or a mixture of two or more kinds of oils Can be used in combination.

The water phase is composed of water-soluble raw materials capable of exhibiting skin moisturization, nutrition, feeling of use, low-temperature stability, efficacy, etc. such as polyol, polymer compound and salts, and it is preferable to use 40 to 80% . If less than 40% by weight of the total weight of the composition is used, there is a problem that the feeling of use is significantly lowered. If the composition is used in excess of 80% by weight, cosmetic preparation is not easy.

The polyol may be at least one selected from the group consisting of glycerin, dipropylene glycol, butyleneglycol, pentaerythritol, methylpropanediol, sorbitol, diglycerin, erythritol, pentaerythritol, polybutyleneglycol- Polyglycerin-10, polyglycerin-20, polyglycerin-40, sorbes-5, sorbes-6, sorbes-20, sorbes-30, sorbes- But are not limited to, inositol, maltitol, maltose, mannan, mannitol, mannose, lactitol, lactose, dihydroxypropyl PG-glucoside, dithiaoctanediol, fructose, glucamine, methylglucamine, Hexanediol, hexanediol, hexanediol, methylglycine-10, methylglucoseth-20, ozonized glycerin, phytantriol, thioglycerin, traitol, trimethylolpropane and xylitol may be used singly or in combination of two or more have.

The retinol-containing hypoallergenic composition for improving wrinkles of the present invention may further comprise a skin improving agent. Examples of the skin improving agent include disodium phenyldibenzimidazole tetrasulfonate, diosmetin, magnesium ascorbyl phosphate, mace lignan, aloe vera, butyl methoxydibenzoyl methane, bis-ethylhexyloxyphenol methoxyphenyl triazine, Extracts of seeds, acetyl phytosphingosine, ascorbyl glucoside, asialicoside, arbutin, ethyl ascorbyl ether, ethylhexyl methoxycinnamate, ethylhexyltriazone, ethylhexylsalicylate, octocrylene, soluble licorice extract , Peony extract, ginsenoside alginate, zinc oxide, titanium oxide, polyhedin, polyethoxylated retinamide, flangenidine, hydroxyproline, arbutin, homosalate, human oligopeptide-1, , Apathiomonaflus aqua extract, Chuncheoncho cactus extract, Chrysanthemum root extract, Fox bead extract Polyethoxylates Amide, poly datin, kinetin, Rick amino butyric acid, oligonucleotide may be at least one member selected from peptide-2, a blank extract, peony extract, blueberry extract, ginseng extract and fermented sugar group consisting of cane extract.

The cosmetic composition according to the present invention can be prepared conventionally in the art and in addition to the above-mentioned ingredients, it is possible to use the amber extract, hibiscus flower extract, madonna lily flower extract, plum extract, chrysanthemum flower extract, , Vegetable extracts such as Ganoderma lucidum root extract, Bdelia extract, Thymus oriental extract, Fennel extract, Hop extract, Lemon balm leaf extract, Mistletoe leaf extract, Chamomile flower extract and Western mushroom extract, Mace lignan extract, Butyl methoxydibenzoyl Methane, bis-ethylhexyloxyphenol, methoxyphenyltriazine, succulent seed extract, acetyl phytosphingosine, ascorbyl glucoside, asialicoside, arbutin, ethyl ascorbyl ether, polyethoxylated retinamide, Nitin, Hydroxyproline, Arbutin, Stabilizer, Vegetable Oil, Animal Oil, Sum An antioxidant, a pH adjuster, and the like may be appropriately added and used as needed.

The cosmetic composition of the present invention can be prepared into any of the formulations conventionally produced in the art and can be used in the form of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, , Oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it can be prepared in the form of lotion, lotion, nutritional cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used have.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder in the composition may be used. Particularly in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane, such as butane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a solubilizing agent or an emulsifier is used in the composition, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, - butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan.

When the formulations of the present invention are in the form of a suspension, they may contain water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the amount of the surfactant in the cosmetic composition may be selected from the group consisting of aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

The present invention also provides a method for relieving skin irritation while improving wrinkles of the skin using the retinol-containing hypoallergenic cosmetic composition.

The cosmetic composition according to the present invention has a remarkably improved effect on skin wrinkles by containing retinol at a high concentration, while at the same time, it is used as a stimulant emollient in combination with a burdock seed extract and a anti-inflammatory complex, Thereby giving a greatly alleviating effect and having excellent skin hypolipidemic effect.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate exemplary embodiments of the invention and, together with the description of the invention, It should not be construed as limited.
FIG. 1 is a graph showing the results of analysis of a wrinkle plate after using the retinol-containing hypothetical water-in-oil type cosmetic composition according to the present invention for 3 weeks.
FIG. 2 is a graph showing skin irritation (visual stimulation evaluation) according to time with use of the retinol-containing hypothetical water-in-oil type cosmetic composition according to the present invention.
FIG. 3 is a graph showing the skin irritation degree (sensory stimulation evaluation) with time in use of the retinol-containing hypothetical water-in-oil type cosmetic composition according to the present invention.

Hereinafter, examples and test examples will be described in detail to facilitate understanding of the present invention. However, the examples and test examples according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following examples and test examples. The embodiments and test examples of the present invention are provided to enable those skilled in the art to more fully understand the present invention.

≪ Examples 1 to 3 and Comparative Examples 1 to 3 >

The raw materials 1 to 8 of the oil phase are weighed in a beaker according to each component and content (% by weight) shown in the following Table 1 and mixed uniformly using a HOMO MIX at a temperature of 75 to 80 ° C. Weigh the raw materials 9, 10, 18, and 19 in the beaker and mix them uniformly using HOMO MIX at a temperature of 75 to 80 ° C. The uniformly mixed aqueous phase is slowly added to the oil phase, and then emulsified at 75 to 80 DEG C at 5000 rpm for 10 minutes. After emulsification and cooling, the ingredients 11 to 17 and 20 were added at 45 to 50 캜, emulsified at 5000 rpm for 3 minutes, defoamed and cooled to prepare a retinol cosmetic.

Raw material (% by weight) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 One Hydrogenated polydecene 13.0 13.0 13.0 13.0 13.0 13.0 2 Squalane 5.0 5.0 5.0 5.0 5.0 5.0 3 Caprylic / capric triglyceride 4.0 4.0 4.0 4.0 4.0 4.0 4 Three tilipies / piperazine-10/1 dimethicone 3.0 3.0 3.0 3.0 3.0 3.0 5 Dimethicone 2.0 2.0 2.0 2.0 2.0 2.0 6 Nutmeg extract 1.0 1.0 - 1.0 - - 7 Burdock seed extract 1.0 1.0 1.0 - 2.0 - 8 Quaternium-18 hectolite 0.6 0.6 0.6 0.6 0.6 0.6 9 Purified water To 100 10 glycerin 5.0 5.0 5.0 5.0 5.0 5.0 11 Alanylglutamine 2.0 - 2.0 2.0 - - 12 Arnica flower extract 1.0 1.0 - 1.0 - - 13 Algae extract 1.0 1.0 - 1.0 - - 14 Panthenol 1.5 - 1.5 1.5 - 1.5 15 Beta-glucan 0.5 0.5 - 0.5 - - 16 Ginseng extract - - - - - 5.0 17 Marchia extract - - - - - 5.0 18 Salt 1.0 1.0 1.0 1.0 1.0 1.0 19 antiseptic Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 20 Retinol 0.18 0.18 0.18 0.18 0.18 0.18

The cetylpyridyl / piperidine-10/1 dimethicone (raw material 4) was used as a surfactant.

≪ Comparative Example 4 &

1.0 weight% of nutmeg extract, 1.0 weight% of burdock seed extract, 1.0 weight% of cetostearyl alcohol, 1.0 weight% of self emulsifying monostearate, 0.5 weight% of wax, 5.0 weight% of squalane, 3.0 weight% of isocetyl octanoate, 0.3 weight% of siloxane, 0.5 weight% of monostearic acid sorbitan, 8.0 weight% of monostearic acid polyethylene glycol, 5.0 weight% of glycerin, 2.0 weight% of alanylglutamine, 1.0 weight% of arnica flower extract, 1.0 weight% 0.5% by weight of beta-glucan, 0.22% by weight of carboxy polymer, 0.22% by weight of triethanolamine, and an appropriate amount of preservative and balance of purified water to prepare retinol cosmetic compositions.

Test Example 1 Evaluation of wrinkle improvement

The wrinkle-improving effect of the retinol-containing hypothetical water-in-oil type cosmetic preparation of the present invention prepared in Example 1 was evaluated in vivo. Twenty - eight adult women between 35 and 60 years of age were tested for wrinkles of the skin by applying to the wrinkles around the eyes once a day (evening) for 3 weeks. The wrinkle measurement is a quantitative analysis of the wrinkles of the test plate through the image analysis method, and the following items are measured and shown in Fig.

- Rt (Skin Roughness R1): The maximum height of the bend of the wrinkle and the distance of the lowest valley.

- Rm (Maximum Roughness R2): R1 value which is the largest value among the R1 values of each section obtained by dividing the wrinkle bend into 5 equal sections.

- Rz (Average Roughness R3): Average value of R1 values obtained after dividing the wrinkle curve into 5 equal parts

- Rp (Smoothness Roughness R4): Average distance between the average profile of the wrinkle height and the wrinkle surface

- Ra (Arithmetic Average Roughness R5): Standard deviation of R4

- Rt (R1), Rm (R2), and Rz (R3) reflect the depth of wrinkles.

- Rp (R4) and Ra (R5) denote skin roughness and depth of shallow wrinkles

- The smaller the value of R1 ~ R5, the lower the depth of wrinkles and the uniformity of skin surface.

The units of R1 to R5 are arbitrary units.

As shown in FIG. 1, when the retinol-containing hypothetical water-in-oil type cosmetic preparation prepared according to the present invention was used, skin wrinkles were remarkably improved.

≪ Test Example 2 > Evaluation of skin irritation 1:

To evaluate the skin irritation of retinol cosmetic preparations according to the formulations of Example 1 and Comparative Example 4, evaluation was made by the following cumulative patch evaluation method which can observe the skin irritation difference more closely. The subjects were 20 men and 20 women in the elderly who were applying folds of 100 mg to the inside of the elbow. They were applied twice a day (9:00 am, 7:00 pm) for 7 days, Respectively. The skin irritation index was calculated according to the following formula 1 by observing the skin irritation degree as shown in Table 2 below. Visual and sensory stimuli according to the passage of time were evaluated and shown in Figures 2 and 3, respectively.

Irritation degree
(Score) Stimulus response
(Reaction) Criteria 0 - No symptoms One + - If you have only a slight erythema and tingling reaction 2 + Clear erythema, tingling, edema, but no blisters 3 ++ If you have a clear erythema, tingling, swelling, blisters 4 +++ When there is a logarithm

[Equation 1]

Skin irritation index = irritation degree x (number of subjects to be tested / total number of subjects to be tested)

2 and 3, when retinol cosmetics of the water-in-oil type of Example 1 according to the present invention were used, skin irritation was remarkably reduced in both the visual evaluation and the sensory evaluation as compared with the retinol cosmetic composition of Comparative Example 1 . From this, it was found that the stimulation stability to the skin was much better than that of the water-in-oil type cosmetic of the present invention.

≪ Test Example 3 > Evaluation of skin irritation 2: Evaluation of closed pellets

In order to evaluate the skin irritation for the retinol cosmetic compositions of Examples 1 to 3 and Comparative Examples 1 to 3, evaluation was conducted by a hermetically closed patch evaluation method capable of comparing and evaluating a large amount of samples at one time. First, a chamber containing about 0.2 g of retinol cosmetics was attached to the arm of 20 healthy adult men and 20 adult women, and after 24 hours, the pin chamber was removed. After 2 hours had elapsed, changes in the skin condition were observed with the naked eye, and the degree of stimulation was evaluated according to the evaluation criteria in Table 2. The skin irritation index was converted using Equation 1, and the results are shown in Table 3 below .

division Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Stimulation index 0.16 0.23 0.27 2.67 1.78 3.2

As shown in Table 3, in the case of Examples 1 to 3 according to the present invention, when the combination of two or more anti-inflammatory complexes together with burdock seed extract was applied, it was found that stimulation was greatly reduced, As shown in Examples 1 and 3, skin irritation was found to be very large when only the combination of other anti-inflammatory complexes alone or without using burdock seed extract was used. In addition, as in Comparative Example 2, skin irritation was somewhat increased even when only burdock seed extract was used without mixing other anti-inflammatory complexes.

From these results, it can be seen that the cosmetic composition of the present invention is particularly effective in the skin hypolipidemic effect when mixed with two or more other anti-inflammatory complexes together with the extract of burdock seeds as the anti-inflammatory complex.

Claims (12)

A hypoallergenic cosmetic composition comprising retinol-containing cosmetic composition for improving wrinkles, wherein the anti-inflammatory complex is contained in an amount of 1 to 30% by weight based on the total weight of the composition. The hypoallergenic cosmetic composition according to claim 1, wherein the composition further comprises 1 to 10% by weight of an emulsifier, 10 to 40% by weight of an oil phase, and 40 to 80% by weight of a water phase. The hypoallergenic cosmetic composition according to claim 1, wherein the composition is a water-in-oil type. The hypoallergenic cosmetic composition according to claim 1, wherein the composition contains the retinol in an amount of 3000 to 6000 IU. The anti-inflammatory complex according to claim 1, wherein the anti-inflammatory complex comprises at least two components selected from the group consisting of a nutmeg extract, alanyl glutamine, acetyltetapeptide-15, arnica flower extract, algae extract, panthenol and beta-glucan, Wherein the composition is a mixture of at least one cosmetic composition. The hypoallergenic composition according to claim 2, wherein the emulsifier is at least two selected from the group consisting of an anionic surfactant, a cationic surfactant, an amphoteric surfactant, and a nonionic surfactant. The composition of claim 2, wherein the emulsifier is an organically modified organopolysiloxane comprising a polyethylene oxide chain, a polypropylene oxide chain, a mixture of such chains, and a dimethicone copolyol; Polydimethylsiloxane modified to include polyether chains comprising moieties derived from both ethylene oxide and propylene oxide; A compound comprising a C2-C30 pendant side chain; Polydimethylsiloxane polyether copolymers with pendant polyethylene oxide side chains, polydimethylsiloxane polyether copolymers with pendant polypropylene oxide side chains, polydimethylsiloxane polyether copolymers with pendant mixed polyethylene oxide and polypropylene oxide side chains, pendent blends Polydimethylsiloxane polyether copolymers with poly (ethylene) (propylene) oxide side chains, polydimethylsiloxane polyether copolymers with pendant organic betaine side chains, polydimethylsiloxane polyether copolymers with pendant carboxylate side chains, pendant Polydimethylsiloxane polyether copolymers with quaternary ammonium side chains; And lauryl dimethicone copolyol, lauryl polydimethylsiloxy ethyl dimethicone copolyol, dimethicone copolyol acetate, dimethicone copolyol adipate, dimethicone copolyol amine, dimethicone copolyol behenate, dimethicone A group consisting of polyol butyl ether, dimethicone copolyol hydroxystearate, dimethicone copolyol isostearate, dimethicone copolyol laurate, dimethicone copolyol methyl ether, dimethicone copolyol phosphate and dimethicone copolyol stearate Wherein the composition is at least one selected from the group consisting of: The hypoallergenic cosmetic composition according to claim 2, wherein the oil phase is at least one selected from the group consisting of silicones, esters, hydrocarbons, vegetable oils and fats. The hypoallergenic cosmetic composition according to claim 2, wherein the water phase is at least one selected from the group consisting of a polyol, a polymer compound and salts. The cosmetic composition according to claim 1, wherein the cosmetic composition is selected from the group consisting of disodium phenyldibenzimidazole tetrasulfonate, diosmetin, magnesium ascorbyl phosphate, mace lignan, castor oil, butylmethoxydibenzoylmethane, bis-ethylhexyloxyphenol, But are not limited to, triazines, aquatic seed extract, acetyl phytosphingosine, ascorbyl glucoside, asialicoside, arbutin, ethyl ascorbyl ether, ethylhexyl methoxycinnamate, ethyl hexyl triazone, ethylhexyl salicylate, , Oil soluble licorice extract, peony root extract, ginsenoside alginate, zinc oxide, titanium oxide, polyhedin, polyethoxylated retinamide, flangenidine, hydroxyproline, arbutin, homosalate, human oligopeptide-1 , Merry Road Extract, Ahni Nominan Flos Aqua Extract, Chunnungwon Cactus Extract, Chrysanthemum Extract, Fox Beads Extract Polyether One or more skin-improving substances selected from the group consisting of licorice extract, laidied retinamide, polydatine, kinetin, aminobutric acid, oligopeptide-2, white paper extract, peony extract, blueberry extract, ginseng extract and fermented sugar- ≪ RTI ID = 0.0 > 5. ≪ / RTI > The cosmetic composition according to claim 1, wherein the cosmetic composition further comprises at least one additive selected from the group consisting of a stabilizer, a vegetable oil, an animal oil, a synthetic oil, an ultraviolet screener, a flavor, an antioxidant, A hypoallergenic cosmetic composition. 11. A method for alleviating skin irritation while improving wrinkles of the skin using the hypoallergenic cosmetic composition according to any one of claims 1 to 11.

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