KR20140077911A - 암의 치료를 위한 포스파티딜이노시톨 3-키나아제 저해제 - Google Patents

암의 치료를 위한 포스파티딜이노시톨 3-키나아제 저해제 Download PDF

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Publication number
KR20140077911A
KR20140077911A KR1020147009539A KR20147009539A KR20140077911A KR 20140077911 A KR20140077911 A KR 20140077911A KR 1020147009539 A KR1020147009539 A KR 1020147009539A KR 20147009539 A KR20147009539 A KR 20147009539A KR 20140077911 A KR20140077911 A KR 20140077911A
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KR
South Korea
Prior art keywords
nhc
phenyl
compound
amino
alkyl
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KR1020147009539A
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English (en)
Korean (ko)
Inventor
아서 데실리스
로드리고 루이즈 소토
개리 토마스 에몬스
조앤 라거
Original Assignee
엑셀리시스, 인코포레이티드
사노피
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Application filed by 엑셀리시스, 인코포레이티드, 사노피 filed Critical 엑셀리시스, 인코포레이티드
Publication of KR20140077911A publication Critical patent/KR20140077911A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020147009539A 2011-09-14 2012-09-14 암의 치료를 위한 포스파티딜이노시톨 3-키나아제 저해제 KR20140077911A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161534836P 2011-09-14 2011-09-14
US61/534,836 2011-09-14
US201161543529P 2011-10-05 2011-10-05
US61/543,529 2011-10-05
US201161562670P 2011-11-22 2011-11-22
US61/562,670 2011-11-22
PCT/US2012/055387 WO2013040337A1 (fr) 2011-09-14 2012-09-14 Inhibiteurs de phosphatidylinositol 3-kinase pour le traitement du cancer

Publications (1)

Publication Number Publication Date
KR20140077911A true KR20140077911A (ko) 2014-06-24

Family

ID=46940622

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147009539A KR20140077911A (ko) 2011-09-14 2012-09-14 암의 치료를 위한 포스파티딜이노시톨 3-키나아제 저해제

Country Status (10)

Country Link
EP (1) EP2755654A1 (fr)
KR (1) KR20140077911A (fr)
AU (1) AU2012308414A1 (fr)
BR (1) BR112014005858A2 (fr)
CA (1) CA2848724A1 (fr)
IL (1) IL231448A0 (fr)
IN (1) IN2014CN02671A (fr)
TW (1) TW201325592A (fr)
UY (1) UY34339A (fr)
WO (1) WO2013040337A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113754565B (zh) * 2021-11-09 2022-02-22 南京威凯尔生物医药科技有限公司 一种连续流微反应器中制备沙库巴曲中间体的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US7019002B2 (en) 2001-12-11 2006-03-28 Pharmacia & Upjohn, S.P.A. Pyridopyrimidinones derivatives as telomerase inhibitors
WO2007044481A1 (fr) 2005-10-07 2007-04-19 Basf Corporation Composition de revetement d’enduit lustre
US8044062B2 (en) 2005-10-07 2011-10-25 Exelixis, Inc. Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha
BRPI0617162B8 (pt) * 2005-10-07 2021-05-25 Exelixis Inc compostos inibidores de fosfatidilinositol 3-quinase composições farmacêuticas que os contem e métodos de uso dos mesmos
CN101959516B (zh) * 2007-04-11 2013-05-08 埃克塞里艾克西斯公司 用以治疗癌症的包含喹喔啉PI3Kα抑制剂的组合治疗
WO2010146391A1 (fr) * 2009-06-15 2010-12-23 Generics [Uk] Limited Synthèse régiosélective de létrozole
WO2012065057A2 (fr) * 2010-11-12 2012-05-18 Exelixis, Inc. Inhibiteurs de la phosphatidylinositol 3-kinase et leurs procédés d'utilisation

Also Published As

Publication number Publication date
EP2755654A1 (fr) 2014-07-23
UY34339A (es) 2013-04-30
WO2013040337A1 (fr) 2013-03-21
IN2014CN02671A (fr) 2015-07-03
WO2013040337A9 (fr) 2014-04-03
TW201325592A (zh) 2013-07-01
IL231448A0 (en) 2014-04-30
AU2012308414A1 (en) 2014-05-01
CA2848724A1 (fr) 2013-03-21
BR112014005858A2 (pt) 2017-06-13

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