KR20140069871A - A blood filtering apparatus and a blood separation apparatus comprising the blood filtering apparatus - Google Patents

Abstract

Disclosed are a blood filtering apparatus and a blood separation apparatus comprising the same. The blood filtering apparatus comprises: a chamber which includes first and second connection pipes which have internal spaces for accommodating blood and are formed on both external sides; a first filter which is included inside the chamber and has a plurality of openings; and a second filter which is included in one side of the first filter and has a plurality of denser openings than that of the first filter. Such blood separation apparatus including the blood filtering apparatus has one or more accommodation spaces to accommodate blood inside and includes a blood separation kit having combination units on at least one of upper and lower ends and sides. In the combination unit, the blood filtering apparatus for filtering and injecting blood into the blood separation kit is combined. The blood filtering apparatus is identical to the blood filtering apparatus. By using the blood filtering apparatus, blood filtration can be immediately performed while collecting blood from human body or injecting blood into the human body. In addition, the blood separation apparatus including the blood filtering apparatus can immediately filter blood while collected blood is injected into the blood separation apparatus without going through a separate blood filtration process in order to inject blood into the blood separation apparatus.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a blood filtration apparatus and a blood separation apparatus having the blood filtration apparatus. 2. Description of the Related Art [0002]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blood filtration apparatus and a blood separation apparatus having the blood filtration apparatus, and more particularly, to a blood filtration apparatus capable of immediately filtering blood at the time of collection or injection of blood, Separation device.

Patient Rich Plasma (PRP) refers to centrifugation of blood after special treatment, which refers to a plasma component that causes platelets to be more abundantly condensed than normal blood.

Originally platelets contain several growth factors and play an important role in wound healing and skin regeneration. In addition, PRP contains such platelets at a high concentration, and various growth factors have been reported to stimulate the proliferation of peripheral cells and to stimulate the synthesis of abundant components such as collagen.

Accordingly, PRP has recently been used in a variety of fields such as pain treatment fields such as back pain, hair loss treatments, and skin diseases such as skin regeneration and burn treatment.

As a method for separating PRP, there is a method of centrifuging the collected blood to separate the blood components and platelet poor plasma (PPP), and then centrifuging again to extract only PRP.

For separating the PRP through centrifugation, a test tube in the form of a tube or a blood separator is used. Blood collected from the human body is injected into a tube-shaped test tube or blood separator.

Blood collected from the human body may contain foreign substances, agglomerates, and the like that may exist in the blood vessel of the collector. Therefore, in order to inject the blood collected by the blood separator, it is necessary to filter the foreign substances, aggregate, and the like that may be present in the blood. However, the filtration process of the blood was not performed immediately, and it was troublesome to separate it.

In addition, when collecting bone marrow, bone marrow contains foreign substances such as fine bone fragments, clots, and fibrous substances, which may interfere with the smooth separation of bone marrow and occasionally result in a buffy coat layer Which can cause serious side effects when injected into the body.

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a blood filtration apparatus and a blood separation apparatus including the blood filtration apparatus in which bone marrow or blood can be immediately filtered during collection or injection of bone marrow or blood.

In order to solve the above problems, a blood filtration apparatus according to the present invention comprises: a chamber having an inner space for receiving blood and including first and second connection tubes formed on both sides of the outer surface; A first filter provided inside the chamber and having a plurality of openings; And a second filter provided on one side of the first filter and having a plurality of openings, the opening having a shape finer than the opening of the first filter.

In order to solve the above-described problems, a blood separation device according to the present invention includes at least one accommodation space for accommodating blood therein, and a blood separation kit having at least one of an upper end, a lower end and a side, And a blood filtration device coupled to the coupling portion and configured to inject blood while filtering the blood into the blood separation kit. The blood filtration device has a receiving space for receiving blood therein, and is coupled to the coupling portion, A chamber including a first connection pipe and a second connection pipe formed on both outer sides of the cylinder so as to be coupled to each other; a first filter provided inside the chamber and having a plurality of openings; And the second filter includes a plurality of openings, the openings having a shape that is finer than the openings of the first filter.

A blood separation device according to a further embodiment of the present invention comprises a blood separation kit comprising at least one receiving space for receiving blood therein; And a blood filtration device disposed in the accommodation space for injecting blood while filtering the blood into the blood separation kit. The blood filtration device may be a filter for filtering blood or bone marrow injected into the accommodation space. The filter may be a stainless mesh network.

According to the blood filtration apparatus of the present invention, it is possible to easily join with the devices for collecting or separating bone marrow or blood such as a syringe. In the process of collecting bone marrow or blood from a human body or injecting bone marrow or blood into a human body, Or blood can be filtered.

According to the blood separator of the present invention, in order to inject bone marrow or blood into the blood separator, the collected bone marrow or blood is injected into the blood separator without having to undergo a filtration process of the collected marrow or blood It is advantageous that the bone marrow or the blood can be filtered immediately.

1 is a perspective view illustrating a blood filtering apparatus according to an embodiment of the present invention.
Fig. 2 is a use state diagram showing the use state of the blood filtration apparatus of Fig. 1;
3 is an exploded perspective view showing a blood separator according to a first embodiment of the present invention.
4 is a front view showing a front and a partial cross-section of the blood separator according to the first embodiment of the present invention.
5 is a perspective view showing an appearance of a blood separator according to a second embodiment of the present invention.
FIG. 6 is an exploded perspective view of FIG. 5. FIG.
7 is a bottom perspective view illustrating a second stopper of the blood separator according to the second embodiment of the present invention.
FIG. 8 is a perspective view showing the external appearance of the blood separator according to the third embodiment of the present invention, and FIG. 9 is a sectional view of the blood separator shown in FIG.

Hereinafter, a blood filtering apparatus and a blood separating apparatus having the blood filtering apparatus according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. The present invention is capable of various modifications and various forms, and specific embodiments are illustrated in the drawings and described in detail in the text. It should be understood, however, that the invention is not intended to be limited to the particular forms disclosed, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Like reference numerals are used for like elements in describing each drawing. In the accompanying drawings, the dimensions of the structures are enlarged to illustrate the present invention in order to clarify the present invention.

The terms first, second, etc. may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as a second component, and similarly, the second component may also be referred to as a first component.

The terminology used in this application is used only to describe a specific embodiment and is not intended to limit the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In this application, the terms "comprises", "having", and the like are used to specify that a feature, a number, a step, an operation, an element, a part or a combination thereof is described in the specification, But do not preclude the presence or addition of one or more other features, integers, steps, operations, components, parts, or combinations thereof.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the contextual meaning of the related art and are to be interpreted as either ideal or overly formal in the sense of the present application Do not.

Blood filtration device

FIG. 1 is a perspective view of a blood filtration apparatus according to an embodiment of the present invention, and FIG. 2 is a state diagram illustrating a use state of the blood filtration apparatus of FIG.

Referring to FIG. 1, the blood filtration apparatus of the present invention may include a chamber 110, a first filter 121, and a second filter 122.

The chamber 110 can receive blood injected into the blood to receive the blood. For example, the chamber 110 may include a bottom surface portion 110a, a side surface portion 110b, and a flat surface portion 110c to form an internal space for receiving blood. The bottom surface portion 110a may have a circular plate shape or a rectangular plate shape. The side surface portion 110b may extend vertically upward from the edge of the bottom surface portion 110a. The flat surface portion 110c may be formed on the upper surface of the side surface portion 110b to face the bottom surface portion 110a and may have a circular plate shape or a rectangular plate shape. For example, the bottom surface portion 110a, the side surface portion 110b, and the flat surface portion 110c may be integrally formed.

The chamber 110 may inject blood into the inner space or may discharge blood to the outside. For example, the bottom portion 110a and the center of the flat portion 110c may be opened to communicate with the inner space so that the blood that is accommodated is injected into the inner space or the blood contained in the inner space is discharged to the outside.

The chamber 110 may be connected to other instruments for collection, injection, separation, etc. of blood. For example, the chamber 110 may include a first connection pipe 111 and a second connection pipe 112 so that the chamber 110 may be connected to other devices. The first connection pipe 111 can vertically extend upward from the upper surface of the flat surface portion 110c of the chamber 110 and communicate with the opening at the center of the flat surface portion 110c. The second connection pipe 112 can extend vertically from the upper surface of the bottom surface portion 110a of the chamber 110 and communicate with the opening at the center of the bottom surface portion 110a.

The chamber 110 may be made of a transparent synthetic resin material, and the inside of the chamber 110 may be made of a transparent glass material.

The first filter 121 primarily filters the blood injected into the inner space of the chamber 110. The first filter 121 may be configured such that a plurality of openings are arranged so that foreign substances, agglomerates, and the like in the blood can be filtered. The first filter 121 is disposed in the inner space of the chamber 110. For example, the first filter 121 may be disposed at approximately the midpoint of the inner wall of the side portion 110b of the chamber 110, and may be opposed to the opening of the plane portion 110c of the chamber 110. [ The first filter 121 may be made of a synthetic resin material, or may be made of a flexible material such as a nonwoven fabric. For example, the flexible material may be attached to the rigid ring-shaped structure and the rigid ring-shaped structure may be fixed to the inner wall of the side wall portion 110b of the chamber 110. [

The second filter 122 allows the foreign substances, agglomerates, and the like remaining in the blood filtered through the first filter 121 to be completely filtered. The second filter 122 may be in the form of a plurality of openings arranged. For example, the second filter 122 may have a configuration in which a plurality of openings are arranged in order that the foreign substances, agglomerates, and the like remaining in the blood filtered through the first filter 121 are completely filtered. May be arranged more densely than the arrangement in which the plurality of openings of the plurality of openings are arranged. The second filter 122 is disposed in the inner space of the chamber 110. For example, the second filter 122 is disposed on the bottom surface of the chamber 110 so as to face the first filter 121 at one side of the first filter 121 and oppose the opening of the bottom surface 110a of the chamber 110, May be disposed between the first filter 110a and the first filter 121. The second filter 122 may be made of a synthetic resin material, or may be made of a flexible material such as a nonwoven fabric. For example, the flexible material may be attached to the rigid ring-shaped structure and the rigid ring-shaped structure may be fixed to the inner wall of the side wall portion 110b of the chamber 110. [

The blood filtration apparatus 100 of the present invention can collect blood collected from a human body or can be collected by combining with a conventional syringe used to inject blood into a human body. Hereinafter, the conditions used for collecting and injecting blood are exemplified.

The syringe cylinder 1 is connected to the second connection pipe 112 of the chamber 110 and the syringe needle 2 is connected to the first connection pipe 111 of the chamber 110 ). When the syringe needle 2 is pushed to the outside of the syringe cylinder 1 after injecting the syringe needle 2 in this state and the piston 3 provided in the syringe cylinder 1 is pushed to the outside of the syringe cylinder 1, .

During the flow of blood into the chamber 110, blood passes through the first filter 121, and foreign substances, agglomerates, and the like in the blood are primarily filtered. The blood that has passed through the first filter 121 passes through the second filter 122 again. At this time, since the openings of the second filter 122 are arranged in a more dense form than the openings of the first filter 121, the blood passes through the first filter 121 Foreign substances remaining in the unfiltered blood, agglomerates, etc. may be completely removed. Therefore, when the blood filtration apparatus 100 of the present invention is used, it is possible to collect blood of high quality by filtering blood immediately in the process of collecting blood.

The syringe cylinder 1 in which the blood is contained is connected to the first connection tube 111 of the chamber 110 and the syringe needle 2 is inserted into the chamber 110, To the second connection pipe (112). That is, when blood is collected from the human body, the syringe cylinder 1 and the syringe needle 2 are connected in the opposite manner to the coupling type. This is because the blood collected into the syringe cylinder 1 is filtered while passing through the first filter 121 and the second filter 122 in this order. In this state, when the syringe needle 2 is injected into the human body and the piston 3 provided in the syringe cylinder 1 is pushed toward the front side of the syringe cylinder 1, blood flows into the chamber 110.

When the blood flows into the chamber 110, the blood passes through the first filter 121 and the second filter 122 as in the above-described blood collecting process, so that foreign matter, aggregated lumps, etc. in the blood are filtered, Can be injected. Therefore, in the case of using the blood filtration apparatus 100 of the present invention, it is possible to immediately inject blood into the human body by filtering blood immediately in the process of injecting blood, and to prevent side effects from being caused by the blood being injected into the human body have.

The blood filtration apparatus 100 of the present invention is not limited to being used in the process of collecting blood from a human body or injecting blood into a human body. For example, although not shown in the drawings of the present invention, the bone marrow harvesting needle can be combined with the first connecting tube or the second connecting tube of the chamber to collect bone marrow. The process of filtering the collected bone marrow is similar to the process of blood filtration described above, so a detailed description is omitted.

In one embodiment of the hemofiltration device of the present invention, although not shown, conventional Luer lock tips and Luer lock grooves may be formed around the outer surface of the first connection tube and the second connection tube. The luer lock tip and the luer lock groove may be shaped to spiral up and down the outer circumferential surface of the first connection pipe and the second connection pipe as is well known. When the luer lock tip and the luer lock groove are respectively formed in the first connection tube and the second connection tube, it can be used in connection with the syringe cylinder having the luer lock tip or the luer lock groove and the syringe needle.

Blood separator

≪ Example 1 >

FIG. 3 is an exploded perspective view showing a blood separator according to a first embodiment of the present invention, and FIG. 4 is a front view showing a front view and a partial cross section of the blood separator according to the first embodiment of the present invention.

Referring to FIGS. 3 and 4, the blood separator 200 according to the first embodiment of the present invention may include a blood separation kit 210 and a blood filtration device 220.

The blood separation kit 210 receives blood therein and separates the collected blood through a centrifugation process. For example, the blood separation kit 210 may include a blood storage chamber 211 and a chamber cap 212, and a coupling portion 213.

The blood storage chamber 211 accommodates blood by forming a receiving space therein. The blood storage chamber 211 may be formed in the form of an elongated cylinder having, for example, an upper surface opened to form a receiving space. The outer diameter of the opened upper end of the blood storage chamber 211 may be formed with a threaded portion so that the chamber stopper 212 can be engaged. The blood storage chamber 211 may be made of a transparent synthetic resin material or a transparent glass material.

The chamber cap 212 is detachably coupled to the opened top of the blood reservoir chamber 211 so as to open and close the accommodation space of the blood reservoir chamber 211. The chamber cap 212 includes an outer portion 212a contacting the outer diameter of the opened upper end of the blood reservoir chamber 211 and a medial portion 212b abutting the inner diameter of the opened upper end of the blood reservoir chamber 211 .

A threaded portion may be provided on the inner diameter of the outer portion 212a. The threaded portion can be engaged with the threaded portion provided at the outer diameter of the upper end of the opened upper end of the blood storage chamber 211. [ The inner side portion 212b can be fixedly coupled to the outer side portion 212a. For example, as shown in Fig. 4, a protrusion provided on a side inner circumferential surface of the outer side portion 212a is engaged with a groove provided on a side outer circumferential surface of the inner side portion 212b, so that the inner side portion 212b and the outer side portion 212a are fixedly coupled . The outer portion 212a may be a hard synthetic resin material. The inner portion 212b may be a flexible material, for example, a silicone or rubber material. Thus, by inserting the injection needle through the medial portion 212b, blood that has been separated from the blood separation kit 210 can be extracted.

Although the chamber stopper 212 has been described as including the outer portion 212a and the inner portion 212b, the chamber stopper 212 may omit the outer portion 212a or omit the inner portion 212b. When the inner portion 212b is omitted, the upper portion of the outer portion 212a must be completely closed. When the outer portion 212a is omitted, the upper surface of the inner portion 212b is formed in the upper end of the chamber cap 212 And should be formed to have the same size or a larger size so as to be completely in contact with the open top of the chamber stopper 212.

The coupling part 213 allows the blood separation kit 210 and the blood filtration device 220 to be coupled. For example, the engaging portion 213 may be formed on the side surface of the blood storage chamber 211. The coupling portion 213 may have a tubular shape protruding from a side portion of the blood reservoir chamber 211.

The blood filtration device 220 may include a chamber 221, a first filter 224, and a second filter 225. The chamber 221 may include a bottom portion 221a, a side portion 221b, and a flat portion 221c to form an internal space for receiving blood. The chamber 221 may include a first connection tube 222 and a second connection tube 223 for connection with the blood separation kit 210 and other instruments.

The second connection pipe 223 is detachably coupled to the coupling part 213 of the blood separation kit 210 so that the blood filtration device 220 can be attached to and detached from the blood separation kit 210. For example, the second connection pipe 223 may be coupled to the coupling portion 213 by a screw connection so that the second connection pipe 223 is detached from the coupling portion 213. In this case, the inner diameter of the second connection pipe 223 and the outer diameter of the coupling portion 213 may be formed with threads that can be engaged with each other.

In addition, a stopper 226 may be coupled to the first connection pipe 222. The cap 226 is configured such that foreign substances such as dust are introduced into the blood filtration device 220 and the blood separation kit 210 through the first connection pipe 222 or blood stored in the blood separation kit 210 flows out . For example, the cap 226 may be closely attached to the upper end of the first connection pipe 222. The stopper 226 may be a flexible material, for example, a silicone or rubber material. The collected blood for blood separation can be injected into the blood separation kit 210 and the blood filtration device 220 by inserting the injection needle into the blood filtration device 220 through the stopper 226 .

A detailed description of the bottom surface portion 221a, the side surface portion 221b and the flat surface portion 221c and the first filter 224 and the second filter 225 forming the chamber 221 of the blood filtration device 220 The side surface 110b, the flat surface portion 110c and the first filter 121 and the second filter 121 which form the chamber 110 and the chamber 110 of the blood filtration apparatus 100 referring to FIG. (122).

When the blood separator 200 according to the first embodiment of the present invention is used, blood can be injected into the blood separation kit 210 while filtering blood immediately. That is, the needle can be inserted through the stopper 226 provided in the first connection pipe 222 of the blood filtration device 220, and then blood can be injected. Blood injected through the blood filtering device 220 may pass through the first filter 224 and the second filter 225 provided in the blood filtering device 220 so that foreign substances in the blood, agglomerated chunks and the like may be filtered. Therefore, blood of good quality can be injected into the blood separator 200.

When the blood is injected into the blood separation kit 210, the blood separation device 200 is transferred to a centrifuge. After centrifugation by a centrifuge, blood is separated into platelet rich plasma (PRP) and platelet poor plasma (PPP).

When the blood is separated, PRP in the separated blood can be extracted after the injection needle is inserted through the inner part 212b of the chamber cap 212. [

≪ Example 2 >

FIG. 5 is an exploded perspective view of the blood separator according to the second embodiment of the present invention, FIG. 6 is an exploded perspective view of FIG. 5, and FIG. 7 is a perspective view of the second stopper of the blood separator according to the second embodiment of the present invention. It is a bottom perspective view for explaining.

5 and 6, the blood separator 300 according to the second embodiment of the present invention includes a center cell 310, a first kit 320, a second kit 330, a blood filtration unit 340, . ≪ / RTI >

The center cell 310 may be disposed in the center of the blood separator 300. The center cell 310 may include an upper portion 311, a center portion 312, and a lower portion 313 along the longitudinal direction. The upper end 311 of the center cell 310 may include a first opening 311a in an open form and the lower end 313 may include a second opening 313a in an open form. The inside and outside of the center cell 310 can communicate with each other through the first opening 311a and the second opening 313a. The inner space of the center cell 310 may be defined by the first opening 311a and the second opening 313a.

Meanwhile, the center cell 310 may include a coupling portion 312a. The coupling portion 312a allows the blood filtering device 340 to be coupled to the center cell 310. [ For example, the coupling portion 312a may be formed on one side of the central portion 312 of the center cell 310. [ The coupling portion 312a may have a tubular shape protruding from the outer surface of the center cell 310. [ The engaging portion 312a communicates with the inner space of the center cell 310. [

The first kit 320 may be inserted into the upper end 311 of the center cell 310. In this case, at least a part of the upper end 311 may be inserted in the inner direction of the first kit 320. The first kit 320 may include a first stopper 321 and a first rotating cap 322.

The first stopper 321 may be mounted inside the first kit 320. The first stopper 321 can open / close the first opening 311a. The first stopper 321 may include a contact portion 321a and a through hole 321b. The contact portion 321a can contact the first opening 311a. The through hole 321b may be formed through the first stopper 321 at a predetermined distance from the contact portion 321a.

The first rotary cap 322 may be mounted at one end of the first kit 320. The first rotary cap 322 can control the height of the liquid contained in the first kit 320 according to the rotational movement. The first rotary cap 322 includes a handle portion 322a formed at one end of the first kit 320 and an extension portion 322b extending from the handle portion 322a into the first kit 320 can do. The handle portion 322a is bi-directionally rotationally movable, and the extension portion 322b can be adjusted in length by rotational movement of the handle portion 322a. For example, through unidirectional rotation of the handle portion 322a, the length of the extension 322b may gradually decrease and the length of the extension 322b may be increased through rotation in the opposite direction .

The second kit 330 may be coupled to the opposite side of the first kit 320 about the center cell 310. The lower end 313 of the center cell 310 may be inserted into the second kit 330 so that at least a portion of the lower end 313 of the center cell 310 is inserted into the second kit 330 . The second kit 330 may include a second stopper 331 and a second rotating cap 332.

The second stopper 331 can open / close the second opening 313a by moving up and down. 7, the second stopper 331 may include a rotation portion 331a, a support portion 331b, and a contact portion 331c. The rotation part 331a may be exposed at one end of the second rotation cap 332. [ The rotating portion 331a may be rotatable by a user. The support portion 331b extends from the rotation portion 331a to the inside of the second kit 330 and can support the contact portion 331c and has a length extending into the second kit 330 by the rotation of the rotation portion 331a Lt; / RTI > The contact portion 331c can receive the second opening 313a.

Blood movement between the second kit 330 and the center cell 310 can be controlled by moving the second stopper 331 up and down. That is, the user can adjust the distance between the contact portion 331c and the second opening 313a of the second stopper 331 by rotating the rotation portion 331a. The contact portion 331c of the second stopper 331 can come into contact with the second opening 313a of the center cell 310 by the rotation of the rotating portion 331a. In this case, the second opening 313a is closed, and the blood movement between the second kit 330 and the center cell 310 can be blocked.

The second rotary cap 332 may include a handle portion 332a formed at one end of the second kit 330 and an extension portion 332b extending from the handle portion 332a into the second kit 330 . The handle portion 332a is rotatable in both directions and the extension portion 332b is adjusted in length by rotational movement of the handle portion 332a. The user can adjust the height of the blood contained in the second kit 330 and the center cell 310 by adjusting the length of the extension 332b of the second rotary cap 332. [ The extended portion 332b may be formed to extend through the support portion 331b of the second stopper 331. [

5 and 6, the center cell 310 is inserted into the first kit 320 and the second kit 330, respectively. For example, the center cell 310 includes a first threaded portion 311b on the upper or upper end 311 of the center portion 312 and a second threaded portion 311b on the lower or lower end 313 of the center portion 312. [ 313b. The first threaded portion 311b may be fastened to the first threaded portion 320a formed at the lower end of the first kit 320 and the second threaded portion 313b may be fastened to the first threaded portion 320b formed at the upper end of the second kit 330 2 threaded boss 330a. The coupling length of the center cell 310 and the first kit 320 can be adjusted by the rotational movement of at least one of the center cell 310 and the first kit 320, The coupling length of the center cell 310 and the second kit 330 may be adjusted by the rotational movement of at least one of the center cell 310 and the second kit 330.

Referring again to FIGS. 5 and 6, the blood filtering device 340 may include a chamber 341, a first filter 344, and a second filter 345. The chamber 341 may include a bottom surface portion 341a, a side surface portion 341b, and a flat surface portion 341c to form an internal space for receiving blood. The chamber 341 may include a first connection tube 342 and a second connection tube 343 for connection with the center cell 310 and other instruments. The second connection pipe 343 is detachably coupled to the coupling portion 312a of the center cell 310 so that the blood filtering device 340 can be attached to and detached from the center cell 310. [

The detailed description of the bottom surface portion 341a, the side surface portion 341b, the flat surface portion 341c and the first filter 344 and the second filter 345 forming the chamber 341 of the blood filtration apparatus 340 The side surface 110b, the flat surface portion 110c and the first filter 121 and the second filter 121 which form the chamber 110 and the chamber 110 of the blood filtration apparatus 100 referring to FIG. A detailed description of the configuration in which the second connection pipe 343 is attached to and detached from the connection portion 312a is the same as the description of the second connection pipe 122 of the blood separation device 200 223 and the engaging portion 213 are attached and detached.

In addition, a plug 346 may be coupled to the first connector 342. A detailed description of the cap 346 is substantially the same as that of the cap 226 of the blood separator 200 with reference to FIG.

The coupling unit 312a is formed in the center cell 310 and the blood filtering apparatus 340 is disposed on one side of the center cell 310. However, the present invention is not limited to this, and the first kit 320 or The blood filtering device 340 may be disposed on one side of either the first kit 320 or the second kit 330. In this case,

When the blood separator 300 according to the second embodiment of the present invention is used, blood can be injected into the blood separator 300 while filtering blood immediately. That is, blood can be injected through the plug 346 provided in the first connection pipe 342 of the blood filtration device 340 after inserting the injection needle. Blood injected through the blood filtering device 340 may pass through the first filter 344 and the second filter 345 provided in the blood filtering device 340 so that foreign substances in the blood, aggregated lumps and the like may be filtered. Therefore, blood of good quality can be injected into the blood separator 300.

When the blood is injected into the central cell 310 through the blood filtering device 340, the blood separator 300 is turned upside down so that the first kit 320 is moved to the center cell 310, And then centrifugal separation can be performed. In this case, the first stopper 321 can open the first opening 311a and the second stopper 331 can close the second opening 313a. Next, using the first rotating cap 322, the plasma and the buffy coat are placed in the center cell 310, and the blood cells are placed in the first kit 320. Thereafter, the first kit 320 or the center cell 310 is rotated so that the first stopper 321 closes the first opening 311a. Thereafter, when the blood separator 300 is again turned over and subjected to secondary centrifugation, enriched platelet rich plasma (PRP) and platelet poor plasma (PPP) are formed in layers. The second rotary cap 332 is used to adjust the position of the PRP and then the second rotary cap 332 is rotated to close the second opening 313a.

In this way, the blood can be centrifuged twice inside the blood separator 300 and is not exposed to the outside air, thereby preventing infections caused by exposure to air during blood separation.

≪ Example 3 >

FIG. 8 is a perspective view showing the external appearance of the blood separator according to the third embodiment of the present invention, and FIG. 9 is a sectional view of the blood separator shown in FIG.

8 and 9, the blood separator 400 according to the third embodiment of the present invention includes an upper cap 410, a first kit 420, a stopper 430, a second kit 440, A second cap 450, and a blood filtration device 460. By these components, a total of three space portions used for separation of blood are formed, and these space portions can be opened or closed with each other.

The upper cap 410 is provided to cover the upper end of the first kit 420. The upper cap 410 includes an outer portion 411 contacting the outer diameter of the upper cylindrical portion 421 of the first kit 420 to be described later and a lower cylindrical portion 421 fixedly coupled to the outer portion 411, And an inner side portion 412 which is in contact with the inner diameter of the inner side portion 421.

A screw portion 413 is provided on the inner diameter of the outer side portion 411 of the upper cap 410. The screw portion 413 has a threaded portion 426 provided on the upper cylindrical portion 421 of the first kit 420, Possibly threaded. The upper cap 410 can be moved up and down with respect to the first kit 420 by rotating the upper cap 410 with respect to the first kit 420. Thereby, the amount of blood contained in the inner space (first space) of the first kit 420 becomes adjustable.

The inner portion 412 of the upper cap 410 is fixedly coupled to the outer portion 411. 9, a protrusion provided on a side inner peripheral surface of the outer side portion 411 is engaged with a groove provided on a side outer peripheral surface of the inner side portion 413, so that the inner side portion 412 and the outer side portion 411 can be fixedly coupled .

The inner portion 412 may be a flexible material, for example, a silicone or rubber material. Blood can be injected into the blood separator 400 by inserting the injection needle through the medial portion 412 or blood separated from the blood separator 400 can be extracted. Since the inner side part 412 is formed of a flexible material, the inner side part 412 can be closely attached to the upper cylindrical part 421 of the first kit 420. Thereby, sealing is performed between the upper cap 410 and the first kit 420 so as not to leak the fluid without a separate sealing member.

The first kit 420 is disposed below the upper cap 410 and includes a first space for receiving blood therein. The first kit 420 includes an upper cylindrical portion 421 and a lower cylindrical portion 422 integrally connected to the upper cylindrical portion 421. The first kit 420 includes an upper cylindrical portion 421 and a lower cylindrical portion 422, And a neck portion 424 formed on the upper side of the inner cone portion 423. The neck portion 424 is provided with a first opening portion 424a and the first space is vertically separated into the upper space 420a and the lower space 420b by the first opening portion 424a.

An upper threaded portion 426 is formed at the upper end of the outer side surface of the upper cylindrical portion 421 to be engaged with the threaded portion 413 of the upper cap 410 described above. A lower threaded portion 427 is provided at the lower end of the outer surface of the lower cylindrical portion 422 to engage with an upper threaded portion 435 of a stopper 430 described later. The screwing between the lower cylindrical portion 422 and the stopper 430 will be described later.

The inner cone portion 423 is formed in a conical shape whose diameter is reduced toward the upper side toward the inner space (first space) at the portion where the upper cylindrical portion 421 and the lower cylindrical portion 422 are in contact with each other. At the upper end of the inner cone portion 423, a tubular neck portion 424 formed to extend upward is provided. The first space is separated upward and downward through the neck portion 424, and the components of the blood are freely moved up and down during centrifugation of the blood. In addition, when centrifugation of the blood is completed, the neck portion 424 is closed to spatially separate the blood.

The stopper 430 is disposed between the first kit 420 and the second kit 440. The stopper 430 includes an outer cylindrical portion 431, a plate 432 located at the center of the inner diameter of the outer cylindrical portion 431, a first bar 433 protruded upward from the upper surface of the central portion of the plate 432, And a second bar 434 protruded downward from the center bottom surface of the plate 432. [

An upper threaded portion 435 is provided on the inner side of the outer cylindrical portion 431 to engage with the lower threaded portion 427 of the first kit 420 described above. The stopper 430 and the first kit 420 are rotatably screwed together so that the first kit 420 can be moved up and down with respect to the stopper 430. As a result, The first opening 424a can be opened and closed.

A lower threaded portion 436 is provided on the lower side of the inner side surface of the outer cylindrical portion 431 to engage with an upper threaded portion 447 of a second kit 440 to be described later. The stopper 430 and the second kit 440 are rotatably screwed together so that the second kit 440 can be moved up and down with respect to the stopper 430. As a result, The second opening 443a can be opened and closed.

For example, by moving the first kit 420 upward with respect to the stopper 430, the first opening 424a of the first kit 420 can be opened and the second kit 420 can be opened with respect to the stopper 430. [ The second opening portion 443a of the second kit 440 can be opened by moving the second opening portion 440 downward.

Referring again to FIGS. 8 and 9, a sealing ring 460 may be disposed between the stopper 430 and the first kit 420. The sealing ring 460 is a member made of silicone or rubber, thereby sealing the fluid between the stopper 430 and the first kit 420 so as not to leak.

Also, a sealing ring 470 may be disposed between the stopper 430 and the second kit 440. This sealing ring 470 is a member made of silicone or rubber, thereby sealing the fluid between the stopper 430 and the second kit 440 so as not to leak.

The plate 432 is in the form of a thin plate, and the plate 432 is provided with a communication hole 432a passing through the top and bottom. The communication hole 432a may be spherical, sectorial, or semi-circular as viewed from the top, but is not limited thereto. The communication space between the inner space (first space) of the first kit 420 described above and the inner space (second space) of the second kit 440 described later is in fluid communication with the communicating hole 432a. That is, the lower space 420b of the first kit 420 substantially cooperates with the upper space 440a of the second kit 440, which will be described later.

The first bar 433 and the second bar 434 are long cylindrical members having a constant diameter, but the present invention is not limited to such a shape. The ends of the first bar 433 and the second bar 434 come in contact with the first opening 424a and the second opening 443a to prevent blood flow. The ends of the bar 433 and the second bar 434 may be hemispherical.

The second kit 440 is disposed below the stopper 430 and includes a second space for receiving blood therein. The second kit 420 includes an upper cylindrical portion 441, an upper connecting portion 442 integrally connected to the upper cylindrical portion 441 and decreasing in diameter as the lower portion is lowered, A lower connecting portion 444 integrally connected to the neck portion 443 and gradually increasing in diameter as it goes downward, a lower cylindrical portion 445 integrally connected to the lower connecting portion 444, ). The neck portion 443 is provided with a second opening portion 443a and the second space is vertically separated into the upper space 440a and the lower space 440b by the second opening portion 443a. That is, the second kit 440 has an hourglass shape separated into an upper space 440a and a lower space 440b.

An upper threaded portion 447 is provided at the upper end of the outer side surface of the upper cylindrical portion 441 to be engaged with the threaded portion 436 of the stopper 430 described above. A lower threaded portion 448 is formed at the lower end of the outer surface of the lower cylindrical portion 445 to engage with a threaded portion 452 of a second cap 450 described later. The screwing between the lower cylindrical portion 445 and the second cap 450 will be described later.

Meanwhile, the second space is separated upward and downward through the neck 443 of the second kit 440, and the components of the blood are freely moved up and down during centrifugation of the blood. In addition, when centrifugal separation of the blood is completed, the neck 443 is closed to spatially separate the blood.

The second cap 450 is positioned below the second kit 440 and covers the lower end of the second kit 440. The second cap 450 includes an outer portion 451 contacting the outer diameter of the lower cylindrical portion 445 of the second kit 440 described above.

A screw portion 452 is provided on the inner diameter of the outer side portion 451 of the second cap 450. The screw portion 452 has a screw portion 448 provided on the lower cylindrical portion 445 of the second kit 440 And is rotatably threaded. By rotating the second cap 450 with respect to the second kit 440, the second cap 450 can be moved up and down with respect to the second kit 440. As a result, the amount of blood contained in the inner space of the second kit 440 becomes adjustable. For example, in FIG. 3, since the second cap 450 is moved downward with respect to the second kit 440, the volume of the lower space 440b is increased. In FIG. 4, The volume of the lower space 440b becomes smaller because it is moved upward with respect to the kit 440. [

A sealing ring 480 may be disposed between the second cap 450 and the second kit 440. The sealing ring 480 is a member made of silicone or rubber, thereby sealing the fluid between the second cap 450 and the second kit 440 so as not to leak.

The blood filtration device 460 can filter foreign substances, agglomerates, and the like in the blood, and can be configured inside the second cap 450. In one example, the blood filtering device 460 may be integrally formed with the second cap 450.

The blood filtration device 460 may be a filter having a plurality of openings to filter foreign substances, agglomerates, etc. in the blood. For example, the filter may be configured as a mesh network. The mesh network may be formed of stainless steel. Blood filtered through the blood filtering device 460 may be injected into the interior of the second cap 450. When the blood is injected into the second cap 450, the second kit 440 is moved downward with respect to the stopper 430 so that the second opening 443a of the second kit 440 is opened The blood that has been filtered while being injected through the blood filtering device 460 as the second opening 443a is opened can be injected into the upper space 440a of the second kit 440. [

A connection pipe 453 may be formed at the lower end of the second cap 450 in order to filter and inject blood into the second cap 450. For example, the coupling pipe 453 may have a cylindrical shape, and a common Luer lock tip may be formed around the outer surface of the coupling pipe 453, although not shown. When a luer lock tip is formed on the coupling tube 453, a syringe cylinder having a luer lock groove formed therein, which can be engaged with the luer lock tip, may be coupled to the front end of the syringe cylinder. The luer lock tip and the luer lock groove may be of a shape that rises in a spiral manner on the outer circumferential surface of the front end portion of the cylindrical connecting pipe and the syringe cylinder as is well known. Alternatively, the coupling tube 453 may have a cylindrical shape without a luer lock tip.

A cap 470 for closing the inside of the second cap 450 may be coupled to the connection pipe 453. For example, the stopper 470 may be formed of rubber or a cylinder material. When the stopper 470 is coupled to the connection pipe 453, after the injection needle is coupled to the syringe cylinder, the injection needle is inserted into the second cap 450 through the stopper 470, and then the blood is injected .

The blood separator 400 according to the third embodiment of the present invention can separate blood through two blood centrifuges.

When the syringe cylinder in which the blood is collected is directly coupled to the connection tube 453 provided at the lower end of the second cap 450 or when the stopper 470 is coupled to the connection tube 453, A needle is inserted into the tip of the syringe cylinder to inject blood into the second cap 450. In the process of injecting the blood, the foreign substance, coagulated mass, etc. contained in the blood may be filtered by the filter which is the blood filtering device 460.

The blood filtered by the filter is injected into the upper space 440a of the second kit 450 from the inside of the second cap 450 while the second opening 443a is opened, The first opening 424a of the first kit 420 is closed by the first bar 433 of the stopper 430 and the second opening 443a of the second kit 440 is opened Followed by centrifugation. When the primary centrifugation is completed, the plasma and the buffy coat in the blood are located in the upper space 440a of the second kit 440, and the blood cells are located in the lower space 440b. At this time, the second cap 450 is rotated to appropriately adjust the volume of the lower space 440b, thereby accurately separating the blood components. Thereafter, the second opening portion 443a of the second kit 440 is closed by the second bar 434 of the stopper 430. After the blood separator 400 is turned upside down, that is, after the first kit 420 is positioned on the lower side with respect to the second kit 440, the first opening 424a of the first kit 420 And the secondary centrifugation is performed in an open state. Plasma Plasma Plasma (PRP) and Empty Platelet Plasma (PPP) are formed by dividing into layers. The upper cap 410 positioned at the lower side is rotated to appropriately adjust the volume of the upper space 420a of the first kit 420 and then the stopper 430 is rotated with respect to the first kit 420, The first opening 424a of the kit 420 is closed. The PRP in the separated blood is extracted through the inner portion 412 of the first cap 410 using a syringe.

When the blood separator 400 according to the third embodiment of the present invention is used, blood can be injected into the blood separator 400 while filtering the blood immediately. That is, blood can be injected through the connection pipe 453 of the blood filtration apparatus 460. The blood injected through the connection pipe 453 may pass through the filter, which is the blood filtration device 460, so that foreign matter, coagulated mass, etc. in the blood may be filtered. Therefore, blood of good quality can be injected into the blood separator 400.

In addition, the blood filtering device 460 may include a first filter and a second filter, as shown in Fig.

100, 220, 340: blood filtration device 110, 221, 341: chamber
111, 222, 342: first connection pipe 112, 223, 343: second connection pipe
121, 224, 344: first filter 122, 225, 345: second filter
200, 300: blood separation device 210: blood separation kit
211: blood storage chamber 212: chamber cap
213, 312a: coupling portion 310: center cell
311: upper end 312: center
313: lower end 311a: first opening
313a: second opening 320: first kit
321: first stopper 322: first rotating cap
331: second stopper 332: second rotating cap

Claims (4)

A blood filtration device for filtering blood while collecting or injecting blood,
A chamber having an inner space for receiving blood and including a first connection tube and a second connection tube formed on both sides of the outer surface;
A first filter provided inside the chamber and having a plurality of openings;
And a second filter provided at one side of the first filter and having a plurality of openings, the opening having a shape finer than the opening of the first filter. A blood separation device for blood separation, comprising:
A blood separation kit having at least one receiving space for receiving blood inside, and having a binding portion at least at one of an upper end, a lower end and a side;
And a blood filtration device coupled to the coupling portion and injecting blood while filtering the blood into the blood separation kit,
The blood filtration device
A chamber including a first connection tube and a second connection tube having a receiving space for receiving blood inside and being connected to the coupling part or formed on both outer sides for coupling the syringe cylinder; And a second filter provided at one side of the first filter and having a plurality of openings, the opening having a shape that is finer than the opening of the first filter. A blood separation device for blood separation, comprising:
A blood separation kit including at least one receiving space for receiving blood therein;
And a blood filtration device disposed in the accommodation space for injecting blood while filtering blood into the blood separation kit,
Wherein the blood filtration device is a filter for filtering blood or bone marrow injected into the accommodation space. The method of claim 3,
Wherein the filter is a stainless steel meshes.

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