KR101128087B1 - Blood separating apparatus - Google Patents

Abstract

PURPOSE: A blood separating apparatus is provided to prevent infection due to the exposure of blood to the air in the separation of blood. CONSTITUTION: A blood separating apparatus comprises a core cell(100), a first kit(200), and a second kit(300). The core cell is arranged in the center of a blood separation device and is coupled with the first kit and second kit. The core cell is composed of a top end part, a central part, and a bottom end part in a longitudinal direction. The core cell includes a first opening and a second opening. The first kit includes a first stopper opening and closes the first opening. The second kit includes a second stopper opening and closes the second opening.

Description

Blood Separation Device {BLOOD SEPARATING APPARATUS}

The present invention relates to a blood separation device.

Platelet Rich Plasma (PRP) refers to the centrifugation of blood after special treatment, which refers to the plasma components that make platelets richer than normal blood. Originally, platelets contain several growth factors, which play an important role in wound healing and skin regeneration. In addition, it is reported that such platelets are contained in high concentrations in PRP, and various growth factors stimulate the proliferation of surrounding cells and stimulate abundant synthesis of collagen and other components. Accordingly, PRP has been used in various fields such as pain treatment such as low back pain, hair loss treatment, skin disease such as skin regeneration or burn treatment.

As a method for separating such PRP, the collected blood is centrifuged to separate blood cell components and platelet poor plasma (PPP, Platelet Poor Plasma) and centrifuged again to extract only PRP. However, the conventional separation method using the blood separation device has a problem that the blood may be exposed to the atmosphere during the transfer to the centrifuge vessel, the transfer to the separation vessel including the filter after the blood collection.

The present invention has been made to solve the above-mentioned problems, and an object of the present invention is to provide a blood separation device capable of two centrifugal separations without exposing the blood to the atmosphere.

As a technical means for achieving the above-described technical problem, the apparatus for separating blood according to the first aspect of the present invention, the center cell including a first opening and a second opening of the open form at the upper and lower ends, respectively, A first kit into which the upper end of the center cell is inserted and coupled; and a second kit into which the lower end of the central cell is inserted and coupled; The kit includes a second stopper for opening and closing the second opening.

According to any one of the problem solving means of the present invention described above, two centrifugal separations are possible without exposing blood to the atmosphere through selective opening and closing of the first and second openings.

Moreover, according to any one of the problem solving means of the present invention mentioned above, the movement of the blood in a blood separation apparatus can be controlled using a 1st stopper and a 2nd stopper.

In addition, according to any one of the problem solving means of the present invention described above, it is possible to adjust the height of the blood in the blood separation apparatus using the first rotary cap and the second rotary cap.

In addition, according to any one of the problem solving means of the present invention described above, the distance between the first stopper and the first opening and the distance between the second stopper and the second opening is inserted into the center cell, the first kit and the second kit Can be adjusted.

1 is a perspective view showing a blood separation device according to an embodiment of the present invention.
Figure 2 is an exploded perspective view showing a blood separation device according to an embodiment of the present invention.
3 is a view for explaining a contact process between the first stopper and the first opening according to an embodiment of the present invention.
Figure 4 is a view for explaining the height adjustment of the blood by the first rotary cap according to an embodiment of the present invention.
5 is a perspective view showing a second kit according to an embodiment of the present invention.
6 and 7 are perspective views showing a blood separation apparatus according to a modified embodiment of the present invention.

DETAILED DESCRIPTION Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art may easily implement the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In the drawings, parts irrelevant to the description are omitted in order to clearly describe the present invention, and like reference numerals designate like parts throughout the specification.

Throughout the specification, when a part is "connected" to another part, this includes not only "directly connected" but also "electrically connected" with another element in between. . In addition, when a part is said to "include" a certain component, which means that it may further include other components, except to exclude other components unless otherwise stated.

1 is a perspective view showing a blood separation device according to an embodiment of the present invention, Figure 2 is an exploded perspective view showing a blood separation device according to an embodiment of the present invention.

1 and 2, the blood separation apparatus 10 includes a central cell 100, a first kit 200, and a second kit 300. The central cell 100 may be disposed in the center of the blood separation device 10, and the first kit 200 and the second kit 300 may be fastened to both sides thereof.

The center cell 100 may be composed of an upper end 110, a center 120, and a lower end 130 along the length direction. The central cell 100 may be formed in a shape in which cross-sectional areas decrease from the central part 120 toward the upper end 110 and the lower end 130, respectively. The cross-sectional area may be continuously reduced as shown in FIGS. 1 and 2, but is not limited thereto and may be discontinuously reduced through a stepped shape or the like.

The central cell 100 may include a space for accommodating blood therein. Meanwhile, the upper end 110 of the center cell 100 may include an open first opening 140, and the lower end 130 may include an open second opening 150. The inside and the outside of the center cell 100 may communicate with each other through the first opening 140 and the second opening 150, and the inner space of the center cell 100 may be the first opening 140 and the second opening 150. It can be defined by. In addition, the center cell 100 may have a neck shape extending by a predetermined amount on the sides of the first opening 140 and the second opening 150, respectively.

The first kit 200 may be inserted into and coupled to the upper end 110 of the center cell 100. In this case, at least a portion of the upper end 110 may be inserted in the inner direction of the first kit 200.

The first kit 200 includes a first stopper 210 and a first rotating cap 220 as shown in FIG. The first stopper 210 may be mounted in the first kit 200. As shown in FIGS. 1 and 2, the first stopper 210 may contact the inner side of the first kit 200 along the circumferential direction, but is not limited thereto. The first stopper 210 may open and close the first opening 140 based on the coupling length of the center cell 100 and the first kit 200, which will be described in detail with reference to FIG. 3.

The first rotating cap 220 may be mounted at one end of the first kit 200. The first rotation cap 220 may be adjusted in length of the member extending into the first kit 200 by bidirectional rotation. For example, when the first rotation cap 220 is rotated in one direction, the length of the member extending into the first kit 200 is increased, and when the first rotation cap 220 is rotated in the opposite direction, the length of the member extending into the first kit 200 is increased. May decrease. The first rotary cap 220 according to an embodiment of the present invention can adjust the height of the liquid contained in the first kit 200 according to the rotational movement. This will be described in detail with reference to FIG. 4.

The second kit 300 may be coupled to the opposite side of the first kit 200 with respect to the center cell 100. The center cell 100 may be inserted into and coupled to the lower end 130 of the second kit 300, in which case at least a portion of the lower end 130 of the center cell 100 is inserted into the second kit 300. Can be. The second kit 300 includes a second stopper 310 and a second rotating cap 320 as shown in FIG. 2. The second stopper 310 may be formed integrally with the second rotation cap 320. The second stopper 310 may open and close the second opening 150 by vertical movement, which will be described in detail with reference to FIG. 5.

Center cell 100 according to an embodiment of the present invention is inserted and coupled to the first kit 200 and the second kit 300, respectively. For example, the center cell 100 includes a first threaded portion 160 on the upper or upper portion 110 of the central portion 120, and a second threaded portion () on the lower or lower portion 130 of the central portion 120. 170). The first threaded portion 160 may be fastened to the first screw bone portion 230 formed at the bottom of the first kit 200, and the second threaded portion 170 may be formed at the top of the second kit 300. 2 can be screwed to the bone 330. The combined length of the center cell 100 and the first kit 200 can be adjusted by the rotational movement of at least one of the center cell 100 and the first kit 200, and the center cell 100 and the second kit The combined length of the 300 may be adjusted by the rotational movement of at least one of the center cell 100 and the second kit 300.

In the present exemplary embodiment, the first threaded part 160, the first threaded bone part 230, the second threaded part 170, and the second threaded bone part 330 are illustrated, but are not limited thereto. ), Any fastening means for fastening the first kit 200 and the second kit 300 can be used. In addition, the threaded portion and the threaded bone portion of the present embodiment may be arranged to change positions with each other.

Blood separation device 10 according to an embodiment of the present invention may introduce the blood through the inlet port 180 formed on one side of the central cell (100). In addition, the central cell 100 may include an inlet cap 182 for opening and closing the inlet 180. Specifically, the inlet 180 may be formed through one side of the central portion 120 of the center cell 100. The inlet 180 formed to a predetermined size may be opened and closed by the inlet cap 182. When the inlet 180 is sealed by the inlet cap 182, the blood introduced into the blood separation device 10 passes through the first opening 140 and the second opening 150, and thus, the first kit 200 and the first opening. 2 kit 300 can be moved. Blood moved to the first kit 200 and the second kit 300 is the first rotary cap 220 and the second rotary cap (180) mounted at the end of the first kit 200 and the second kit 300, respectively ( It may not be leaked to the outside of the blood separation device 10 by 320. Meanwhile, the introduced blood is moved between the first kit 200 and the center cell 100 by the first stopper 210 and the second stopper 310 and between the second kit 300 and the center cell 100. This can be blocked.

3 is a view for explaining a contact process between the first stopper and the first opening according to an embodiment of the present invention, and shows a cross section of a part of the first kit and the center cell.

The first stopper 210 according to an embodiment of the present invention includes a contact portion 212 and a through hole 214. The contact part 212 may be in contact with the first opening 140 and may be disposed at a position corresponding to the first opening 140. In addition, the contact portion 212 may include a groove having a predetermined depth to accommodate the first opening 140, but is not limited thereto. The through hole 214 may be formed through the first stopper 210 at a predetermined distance from the contact portion 212. In the present embodiment, the through holes 214 are illustrated to have two half moon shapes on both sides of the contact portion 212, but the present invention is not limited thereto, and the through holes 214 may have any number and any shape. have.

Referring to FIG. 3, the upper end 110 of the center cell 100 is inserted into the first kit 200 and is coupled by the first threaded portion 160 and the first screw bone portion. The distance between the first stopper 210 and the first opening 140 may be adjusted by the rotation of at least one of the center cell 100 and the first kit 200. In this case, the distance between the first stopper 210 and the first opening 140 may be adjusted while the center cell 100 and the first kit 200 are inserted and coupled.

Referring to Figure 3 (a), the first threaded portion 160 of the center cell 100 is coupled to the lower portion of the first screw bone 230 formed in the first kit 200. Since the first stopper 210 and the first opening 140 are separated from each other at a predetermined distance, the inside of the center cell 100 and the first kit 200 may communicate with each other through the through hole 214. If blood flows into the central cell 100 and the first kit 200, the blood may move between the central cell 100 and the first kit 200 through the through hole 214.

3 (a) to 3 (c), the first threaded portion 160 of the center cell 100 moves to the upper side of the first screw bone portion 230. This is possible, for example, by rotational movement of the first kit 200 or the center cell 100. As a result, the distance between the contact portion 212 and the first stopper 210 becomes shorter gradually from Fig. 3 (a) to Fig. 3 (c). Referring to FIG. 3- (c), the first stopper 210 and the first opening 140 are in contact, and as a result, the first opening 140 is closed. In this case, the movement of blood between the first kit 200 and the central cell 100 may be blocked. As described above, the user of the blood separation device 10 may control the blood movement between the first kit 200 and the center cell 100 by rotating the first kit 200 or the center cell 100.

Figure 4 is a view for explaining the height adjustment of the blood by the first rotary cap according to an embodiment of the present invention.

Referring to FIG. 4, the first kit 200 is disposed below the center cell 100. A user of the blood separation device 10 may move the first kit 200 downward by rotating the blood separation device 10 in an arbitrary direction. When the blood 50 is introduced into the blood separation device 10 and centrifuged, the blood 50 may be separated into a plasma 52 and a blood cell 56 layer. In addition, a predetermined amount of platelet 54 layer exists between the plasma 52 and the blood cells 56. The platelet 54 layer may be in the form of a buffy coat, for example. The plasma 52, platelet 54, and blood cell 56 layers are all different in color, and thus can be classified into ductal phases. The user may use the first rotating cap 220 to extract a specific component of the blood 50 or to adjust the height of the blood 50.

The first rotating cap 220 includes a handle portion 222 formed at one end of the first kit 200 and an extension portion 224 extending into the first kit 200 from the handle portion 222. The handle part 222 may be bidirectionally rotated, and the extension part 224 may be adjusted in length by the rotational movement of the handle part 222. For example, through the one-way rotation of the handle part 222, the length of the extension portion 224 may be gradually reduced from Figure 4- (a) to Figure 4- (c). As a result, the height of the blood 50 accommodated in the first kit 200 and the central cell 100 may also be lowered. As shown in FIG. 4 (c), the level of the blood 50 may be adjusted to move a specific layer of blood, such as platelets 54, to the neck of the first opening 140. In the present exemplary embodiment, the length of the extension part 224 is reduced according to the rotation of the handle part 222, but the length of the extension part 224 may be increased.

5 is a perspective view showing a second kit according to an embodiment of the present invention.

Referring to FIG. 5, the second kit 300 includes a second stopper 310 and a second rotating cap 320. The second stopper 310 may be integrally formed with the second rotation cap 320. In addition, as shown in FIG. 5, the second stopper 310 may be formed to penetrate a part of the second rotation cap 320, but is not limited thereto. In addition, the second stopper 310 may open and close the second opening 150 of the center cell 100 by vertical movement.

The second stopper 310 according to the exemplary embodiment of the present invention includes a rotating part 312, a support part 314, and a contact part 316. The rotating part 312 may be exposed at one end of the second rotating cap 320. The rotating unit 312 may be formed to be rotatable by a user. The support part 314 may extend from the rotating part 312 into the second kit 300 to support the contact part 316. In addition, the length of the support part 314 extended into the second kit 300 may be adjusted by the rotation of the rotating part 312. The contact portion 316 may be in contact with the second opening 150.

The contact portion 316 of the second stopper 310 may include a groove having a predetermined depth to accommodate the second opening 150, such as the contact portion 316 of the first stopper 210, on one surface thereof. The user may adjust the distance between the contact part 316 of the second stopper 310 and the second opening 150 by rotating the rotating part 312. The contact part 316 of the second stopper 310 may contact the second opening 150 of the center cell 100 by the rotation of the rotation part 312. In this case, the second opening 150 may be closed, and blood movement between the second kit 300 and the center cell 100 may be blocked. As described above, the user of the blood separation device 10 may control the blood movement between the second kit 300 and the central cell 100 through the vertical movement of the second stopper 310.

The second rotary cap 320 includes a handle portion 322 formed at one end of the second kit 300 and an extension portion 324 extending into the second kit 300 from the handle portion 322. The handle part 322 is bidirectionally rotatable and the extension part 324 is adjusted in length by the rotational movement of the handle part 322. The user may adjust the height of the blood contained in the second kit 300 and the central cell 100 by adjusting the length of the extension 324 of the second rotary cap 320. On the other hand, the expansion portion 324 may be formed to penetrate so that the support portion 314 of the second stopper 310 extends.

At least one of the first kit 200 and the second kit 300 according to an embodiment of the present invention may include an outlet 340 for outflow of blood. For example, as shown in FIG. 5, the second kit 300 may include an outlet 340 formed at one side of the second rotating cap 320. In addition, the second kit 300 may further include an outlet cap 342 for opening and closing the outlet 340. In this embodiment, the outlet 340 and the outlet cap 342 are illustrated to be disposed on the handle portion 322 of the second rotary cap 320, but is not limited thereto. In addition, although the outlet 340 and the outlet cap 342 are illustrated in the present embodiment to be formed in the second kit 300, the present invention is not limited thereto and may be formed in the first kit 200.

After the separation of the blood, the user can discharge at least a portion of the blood through the outlet 340, the vent hole 350 and the vent cap 352 for opening and closing the flow to prevent the smooth air flow and bubbles at the time of outflow It may further include. When the outlet 340 is formed in the first kit 200, the vent 350 and the vent cap 352 may also be formed in the first kit 200, and the outlet 340 may be formed in the second kit 300. When formed, the vent 350 and the vent cap 352 may be formed in the second kit 300.

In addition, the blood separation device 10 according to an embodiment of the present invention may be centrifuged twice without selectively exposing blood to the atmosphere through selective opening and closing of the first opening 140 and the second opening 150. . Specifically, after the blood flows through the inlet 180, the blood separation device 10 may be inverted so that the first kit 200 is positioned below the center cell 100, and then centrifuged. In this case, the first stopper 210 may open the first opening 140, and the second stopper 310 may close the second opening 150. Next, using the first rotating cap 220, the plasma and buffy coat is located in the central cell 100, the blood cells are located in the first kit 200. Thereafter, the first kit 200 or the center cell 100 is rotated to allow the first stopper 210 to close the first opening 140. Thereafter, when the blood separation device 10 is turned upside down and subjected to the second centrifugation, the concentrated multiplatelet plasma (PRP, Platelet Rich Plasma) and the anemia platelet plasma (PPP, Platelet Poor Plasma) are formed by dividing the layers. After adjusting the position of the PRP using the second rotating cap 320, the second opening 150 is closed by rotating the second rotating cap 320. In this way, since the blood can be centrifuged twice inside the blood separation apparatus 10, it is not exposed to the external atmosphere. As a result, there is an advantage that it is possible to prevent the infection due to the air exposure of the blood during separation.

6 and 7 are perspective views showing a blood separation apparatus according to a modified embodiment of the present invention.

Referring to FIG. 6, the blood separation device 20 includes a center cell 100 and two first kits 200 inserted into and coupled to both sides of the center cell 100, respectively. In addition, referring to FIG. 7, the blood separation device 30 includes a center cell 100 and two second kits 300 inserted into and coupled to both sides of the center cell 100, respectively.

The blood separation device may include a first kit 200, a center cell 100, and a second kit 300, as shown in FIGS. 1 to 5, but is not limited thereto. As shown in FIG. 7, two first kits 200 and a center cell 100 may be included, or two second kits 300 and a center cell 100 may be included.

In this case, the first stopper and the second stopper of the first kit 200 and the second kit 300 may open and close the first opening and the second opening of the center cell 100, respectively. Through this, blood movement between the center cell 100 and the first kit 200, the center cell 100, and the second kit 300 may be controlled.

Sub-components and operations of the center cell 100, the first kit 200, and the second kit 300 have been described with reference to FIGS. 1 to 5, and thus descriptions thereof will be omitted within the same range.

The foregoing description of the present invention is intended for illustration, and it will be understood by those skilled in the art that the present invention may be easily modified in other specific forms without changing the technical spirit or essential features of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as distributed may be implemented in a combined form.

The scope of the present invention is shown by the following claims rather than the above description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included in the scope of the present invention. do.

10, 20, 30: blood separation device 50: blood
100: center cell 110: upper portion
120: center 130: lower part
140: first opening 150: second opening
160: first threaded portion 170: second threaded portion
180: inlet 182: inlet cap
200: first kit 210: first stopper
212: contact portion 214: through hole
220: first rotating cap 230: first screw bone portion
300: second kit 310: second stopper
312: rotating part 314: supporting part
316: contact portion 320: second rotating cap
330: second screw bone 340: outlet
342: outlet cap 350: vent
352: vent cap

Claims (13)

In the device for separating blood,
A center cell including a first opening and a second opening each having an open shape at upper and lower ends thereof;
A first kit into which the upper end of the center cell is inserted and coupled;
Including a second kit is inserted into the lower end of the center cell,
The first kit includes a first stopper for opening and closing the first opening,
The second kit comprises a second stopper for opening and closing the second opening.
The method of claim 1,
The center cell is a blood separation device is formed in the form of a cross section decreases toward the upper end and the lower end from the center.
The method of claim 1,
The center cell,
Including a space for receiving the blood,
And the space is defined by the first and second openings.
The method of claim 1,
The center cell,
An inlet for introducing the blood;
Blood separation device comprising an inlet cap for opening and closing the inlet.
The method of claim 1,
The first stopper is,
A contact portion in contact with the first opening portion;
Through hole formed through the contact portion at a predetermined interval
Blood separation device comprising a.
The method of claim 5, wherein
The center cell and the first kit is screwed,
Wherein the distance between the first opening and the contact is controlled by bidirectional rotation of at least one of the center cell and the first kit.
The method of claim 1,
The first kit further includes a first rotating cap mounted at one end,
The first rotating cap,
Bi-directional rotatable handle
An extension part extending from the handle part into the first kit,
The length of the expansion portion is blood separation device that is adjusted by the rotation of the handle portion.
The method of claim 1,
The second kit includes a second rotating cap mounted to one end,
The second rotating cap,
Bi-directional rotatable handle
An extension part extending from the handle part into the second kit,
The length of the expansion portion is blood separation device that is adjusted by the rotation of the handle portion.
The method of claim 8,
The second rotary cap is a blood separation device formed integrally with the second stopper.
The method of claim 9,
The second stopper is,
A rotating part formed to be bidirectionally rotated at one end of the second rotating cap;
A support extending from the rotary part into the second kit; and
A contact portion formed at one end of the support portion and in contact with the second opening portion;
And the distance between the second opening portion and the contact portion is controlled by the rotation of the rotating portion.
The method of claim 1,
At least one of the center cell, the first kit and the second kit is a blood separation device.
The method of claim 1,
At least one of the first kit and the second kit,
Outlets for outflow of blood and
Outlet cap for opening and closing the outlet
Blood separation device comprising a.
The method of claim 12,
At least one of the first kit and the second kit further comprises a vent opening on the side.

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