KR101125073B1 - One body type apparatus for separation of liquid mixture - Google Patents

Abstract

The present invention relates to an integrated separator, and according to an aspect of the present invention, in a separator used to separate a specific component from a material having different specific gravity, the material formed on the lower side and mixed inside A first chamber configured to accommodate a portion; A second chamber formed on the upper side and communicating with the first chamber to accommodate a portion of the mixed material therein; A connecting neck integrally formed between the first chamber and the second chamber; A lower cover part formed to seal a lower side of the first chamber; An upper cover part formed to seal an upper side of the second chamber; And a locking part that is supported by the lower cover part or the upper cover part and is formed to be movable upward and downward, and seals the inside of the connection neck to prevent the mixed material from moving between the first chamber and the second chamber. An integrated separation device is provided.

Description

ONE BODY TYPE APPARATUS FOR SEPARATION OF LIQUID MIXTURE}

The present invention relates to an integrated separation device, and more particularly, a separation device used to separate a specific component from a material having different specific gravity, and in particular, it is easy to separate a large amount of platelet-rich plasma from blood. It relates to a device that can.

Recently, PRP procedures (autologous skin regeneration, injection) have been in the spotlight as a method of skin beauty or skin treatment. Platelet Rich Plasma (PRP) treatment refers to a treatment method using growth factors rich in platelets and differentiation of stem cells through the growth factors, in which growth factors are activated by injecting platelets collected into the skin. It is a treatment method using the principle of differentiating according to the tissue to create new collagen and elastic fibers, etc. that are components of the skin.

Currently, the PRP procedure is recognized as a treatment method that can secure the part that could not be processed by the conventional laser treatment, and can make an ideal combination when combined with the laser.

As described above, the PRP procedure refers to a procedure in which a PRP (Platelet Rich Plasma) is injected from the human body and then injected into the dermal layer of the skin.

As such, in the PRP procedure, PRP should be basically provided, and it is very important to distinguish between PRP (Platelet Rich Plasma) and PPP (Platelet Poor Plasma). The effect of treatment cannot be expected when plasma is used in a state where platelets are not properly concentrated, ie, PPP.

Therefore, prior to the PRP procedure, obtaining a good PRP is an important factor above all, and it is required to extract a high concentration of platelets to make a good quality PRP.

Your body's blood contains about 100,000 to 200,000 platelets per microliter. And for effective PRP procedures, it should be concentrated to the extent that 1 million platelets are contained per microliter. In other words, platelets should be concentrated about 6 to 8 times higher than normal blood collection to say good quality PRP.

In order to obtain such a high concentration of PRP, injecting the collected blood into the container, and then centrifugal separator to separate by concentration, the device for extracting the plasma containing platelets from the blood divided by layer is used.

However, these conventional devices are not only difficult to extract the platelets separated through the centrifuge, but also cause contact with air in the process of first separating the red blood cells, which causes a serious problem of infection.

In addition, when the fineness of the platelets in the blood is very low, it is difficult to properly extract the fine adjustment, the conventional devices do not meet this requirement.

The present invention has been made to solve the problems described above, an embodiment of the present invention is a separation device used to separate a specific component in a material mixed with different specific gravity, in particular platelet in the blood Large amounts of concentrated plasma can be easily separated, accurate extraction of concentrated platelets is possible, and minimizing the risk of infection in the air.

According to one preferred embodiment of the present invention, a separation apparatus used to separate a specific component from a material having different specific gravity is mixed, comprising: a first chamber formed at a lower side and configured to accommodate a portion of the mixed material therein; A second chamber formed on the upper side and communicating with the first chamber to accommodate a portion of the mixed material therein; A connecting neck integrally formed between the first chamber and the second chamber; A lower cover part formed to seal a lower side of the first chamber; An upper cover part formed to seal an upper side of the second chamber; And a locking part which is supported by the lower cover part or the upper cover part and is formed to be movable upward and downward, and seals the inside of the connection neck to prevent the mixed material from moving between the first chamber and the second chamber. There is provided an integrated separation device comprising a.

According to an embodiment of the present invention as described above, first, by connecting the connection neck is formed integrally between the first chamber and the second chamber, and by selectively locking the inside of the connection neck using a locking portion, the first centrifugal separation Through the exclusion of only red blood cells is easily made, secondary centrifugation is effectively performed, the extraction of platelets can be made effectively, and excellent quality PRP can be obtained.

Second, the process of separating the device in the first centrifugation and the second centrifugation process is not necessary, thereby preventing contact with air, and thus preventing infection.

Third, the connecting neck is formed to be narrower than the first chamber and the second chamber, so that the locking portion can easily close the connecting neck and provide a device having a structure suitable for extraction of a relatively small amount of platelets.

Fourth, the second chamber is formed by dividing the chamber core and the chamber body, and the first chamber and the second chamber are formed so as to change the diameter in the inclined form, it is easy to adjust for the separation of components and accurate extraction of platelets It is possible.

Fifth, the injection film and the extraction film made of a soft elastic body is formed in the upper cap constituting the upper cover portion, the injection of the collected blood and the extraction of PRP is easy, and the sealing is ensured.

Sixth, the pressure hole is formed in the center of the lower end of the locking tip constituting the locking portion, it is possible to solve the structural anxiety of the device according to the pressure rise inside the first chamber during the centrifugal separation, and the stable separation is possible.

Seventh, by having an automatic locking device for controlling the vertical movement of the locking portion in the upper cover portion, the secondary centrifugation is automatically made after the first centrifugal separation and can eliminate the hassle of the separation process.

Eighth, the lower cover portion, by adjusting the volume of the interior of the first chamber, such as made of a control plate and the adjusting device, it is possible to separate the platelets relatively accurately according to the amount of blood injected or the ratio of separated blood components.

1 is a perspective view showing an integrated separation device according to an embodiment of the present invention,
FIG. 2 is a sectional view showing the unitary separating device shown in FIG. 1;
3 (a) and 3 (b) is a cross-sectional view showing a state of use of the integrated separator shown in FIG.
Figure 3 (c) is a cross-sectional view including a block diagram schematically showing the automatic locking intermediate to operate the locking portion shown in Figure 1,
4 is a state diagram showing the integrated separation device shown in FIG.

1 is a perspective view showing an integrated separator 1 according to an embodiment of the present invention. FIG. 2 is a cross-sectional view of the integrated separator 1 shown in FIG. 1.

The integrated separator 1 according to a preferred embodiment of the present invention is a separator 1 used to separate a specific component from a substance having different specific gravity mixed therein, which is formed at the lower side and the mixed inside. A first chamber 10 configured to receive some of the material; A second chamber 20 formed at an upper side and communicating with the first chamber 10 to accommodate a portion of the mixed material therein; A connection neck 30 integrally formed between the first chamber 10 and the second chamber 20; A lower cover part 40 formed to seal the lower side of the first chamber 10; An upper cover part 50 formed to seal an upper side of the second chamber 20; And supported by the lower cover part 40 or the upper cover part 50 so as to be movable up and down based on the lower cover part 40 or the upper cover part 50, and of the connection neck 30. And a locking part 60 to seal the inside to prevent the mixed material from moving between the first chamber 10 and the second chamber 20.

The integrated separator 1 according to a preferred embodiment of the present invention is a device used to extract only a specific component from a mixture of components of various concentrations, and after each component is separated by concentration using the centrifugal force of the centrifuge. It is a device to extract specific components.

That is, the separator 1 according to the present invention is a device that rotates at a high speed through a centrifuge and separates each component by using the centrifugal force, rather than separating the mixed material injected therein.

The integrated separation device 1 according to a preferred embodiment of the present invention is not limited to a specific material, but is particularly suitable for extracting platelets from collected blood, and platelets are concentrated at a high concentration of platelet rich. Plasma) is a useful device for obtaining.

Therefore, hereinafter, for convenience of description, it will be described by limiting the mixed material to the blood collected.

The integrated separation device 1 according to a preferred embodiment of the present invention is made so that the blood collected therein is injected and centrifuged to separate the red blood cells, platelets, plasma, etc., each layer of the blood, according to specific gravity. As a result, a space in which the blood is stored is provided, and the first chamber 10 and the second chamber 20 correspond to this. In addition, the integrated separator 1 according to the present invention is formed so that the alternative shape is cylindrical to fit the centrifuge.

The first chamber 10 is located at the lower side and made to receive blood therein. The first blood injected into the device is uniformly mixed with each component, so that the blood first injected into the first chamber 10 also becomes homogeneous, but after centrifugation, the red blood cells having a high specific gravity are added to the first blood. One chamber 10 is filled.

The second chamber 20 is positioned above the first chamber 10, and is formed to have a substantially cylindrical shape like the first chamber 10. The second chamber 20 corresponds to a portion where the plasma component is located in the blood after centrifugation.

In the blood of the human body, red blood cells account for approximately 45%, plasma is 55%, and leukocytes and platelets account for less than 1%, taking into account the volume of the first chamber 10 and the second chamber 20. The proportion is preferably about 45% and 55%.

The connection neck 30 is positioned between the first chamber 10 and the second chamber 20 and is integrally formed with the first chamber 10 and the second chamber 20. Here, the term 'integrally' includes not only a structural form being integrally formed, but also a substantial use form being integrally formed. That is, when the separation of the connection neck 30 portion is not necessary in the process of separating blood through centrifugation, the connection neck 30 portion is substantially connected to the first chamber 10 and the second chamber 20. Even if it is structurally separable.

The lower cover part 40 which seals the lower end of the first chamber 10 is formed below the first chamber 10, and above the second chamber 20 of the second chamber 20. An upper cover part 50 is formed to seal the upper end, and the detailed description of the lower cover part 40 and the upper cover part 50 will be described later.

The locking part 60 is supported by the lower cover part 40 or the upper cover part 50 to be movable up and down. The locking part 60 seals the inside of the connection neck 30 so that the spaces of the first chamber 10 and the second chamber 20 are clearly distinguished, and is opened and closed according to the movement.

Here, a brief description of the separation process of blood according to the device of the present invention.

First, blood collected in the device is injected to fill the inside of the first chamber 10 and the second chamber 20. Thereafter, using a centrifuge to rotate at high speed to separate the blood by concentration. This is referred to as 'first centrifugation' for convenience. In this case, the connection neck 30 is open, and the locking part 60 is spaced apart from the connection neck 30. This is to ensure that the collected blood is divided by the components inside the device.

In the first centrifugal separation, most of the red blood cells are located in the first chamber 10, and white blood cells and platelets are located in the lower side of the second chamber 20, and plasma is located in the upper side of the first chamber 10.

Thereafter, the locking unit 60 is moved to seal the connection neck 30, and the separated red blood cells are blocked from being mixed with the remaining components again. After this process, centrifugation is performed again through a centrifuge, which is referred to as 'secondary centrifugation'.

In the second centrifugation process, red blood cells inside the first chamber 10 are blocked, and platelets are more precisely separated and positioned below the second chamber 20. As described above, in the integrated separator 1 according to the preferred embodiment of the present invention, the connecting neck 30 is integrally formed between the first chamber 10 and the second chamber 20, By selectively sealing the inside of the connection neck 30 by using the locking unit 60, it is easy to exclude only red blood cells through the first centrifugation, and the second centrifugation is effectively performed to extract the platelets. It is easy to achieve, and as a result, a good quality PRP can be obtained.

In addition, the process of separating the device in the first centrifugation and the second centrifugation process (such as separation for the collection of platelets located in the middle of the separated blood) is unnecessary, thereby preventing contact with air. As a result, the risk of infection can be eliminated.

In the integrated separator 1 according to the preferred embodiment of the present invention, the connecting neck 30 is formed to have a smaller diameter than the first chamber 10 and the second chamber 20.

And the second chamber 20, the chamber core 21 is formed adjacent to the connecting neck 30, the diameter smaller than the first chamber 10 and larger than the connecting neck 30; And a chamber body 22 formed on the chamber core 21 and having a larger diameter.

In addition, a portion of the chamber core 21 is made to taper at the portion connected to the connection neck 30 to form a core shoulder 21a.

In addition, a portion of the first chamber 10 is tapered at a portion connected to the connecting neck 30 to form a first shoulder 10a, and a portion of the chamber body 22 is the chamber core 21. Tapered in the portion that follows and forms a second shoulder (22a).

The connection neck 30 is formed smaller in diameter than the first chamber 10 and the second chamber 20. The connecting neck 30 is a means for distinguishing red blood cells that are primarily divided after the first centrifugal separation, and a relatively clear division needs to be made based on the connecting neck 30.

In addition, the connection neck 30 is a part sealed by the locking unit 60, the expansion of the locking unit 60 is also inevitable when the connection neck 30 is enlarged, and thus the ease of manufacturing the device, In consideration of the convenience of blood separation, the connection neck 30 may be formed to be narrower than the first chamber 10 and the second chamber 20.

Unlike the first chamber 10, the second chamber 20 is divided into the chamber core 21 and the chamber body 22.

The chamber core 21 is located on the lower side and occupies a relatively small volume, and the chamber body 22 is located on the chamber core 21 and formed relatively large. The chamber core 21 is a portion where a platelet to be collected is located, and the chamber body 22 corresponds to a portion where plasma is located.

The chamber core 21 is formed to have a larger diameter than the connection neck 30, so that the locking core 60 is spaced apart from the chamber core 21 when the locking part 60 is inserted into and close to the inside of the connection neck 30. Stay intact.

As described above, the specific gravity of platelets in the blood is very small, and the chamber core 21 needs to be formed in a narrow and long form for accurate separation of the platelets.

Here, the chamber core 21 and the chamber body 22 constituting the second chamber 20 are not simply formed in a cylindrical shape, and the lower end portions thereof are inclined, that is, diameters are expanded toward the upper side. In the form of In particular, by collecting the lower end of the chamber core 21 in an inclined form, the platelet can be easily collected. The lower end inclined from the chamber core 21 corresponds to the core shoulder 21a, and the lower end inclined from the chamber body 22 corresponds to the second shoulder 22a.

According to the amount of blood, the size of the device, and the like, the plasma portion in which platelets are concentrated after centrifugation is positioned at the boundary with the chamber core 21 or the chamber body 22, and the chamber nose and the chamber body 22. By tapering the lower end of the platelet and the plasma can be more clearly distinguished, it is possible to accurately collect the platelet to the last amount.

As such, by forming the second shoulder 22a, separation may be made in consideration of specific gravity of plasma and platelets, and the boundary between the two may be more clearly defined.

In addition, by forming the core shoulder 21a, in collecting a relatively small amount of platelets can be accurately collected until the end.

The first shoulder 10a is formed on the upper end of the first chamber 10 in a similar form to the second shoulder 22a. This is also to make the separation in consideration of the specific gravity of the red blood cells in the blood, and to make a more clear division in the connection neck (30).

As such, the connection neck is formed to be narrower than the first chamber 10 and the second chamber 20, so that the locking part 60 can easily seal the connection neck 30, and a relatively small amount. It is possible to provide a device having a structure suitable for the extraction of platelets, the second chamber 20 is formed divided into the chamber core 21 and the chamber body 22, the first chamber 10 and the first Since the two chambers 20 are formed to change in diameter in an inclined form, adjustment for separation of components is easy and accurate extraction of platelets is possible.

In the integrated separating device 1 according to a preferred embodiment of the present invention, a reinforcing rib formed on an outer circumferential surface of the connecting neck 30 and connected to the first chamber 10 and the second chamber 20 to be integrally formed ( 70).

In addition, the first chamber 10, the second chamber 20 and the connection neck 30 is made transparent.

As described above, the connection neck 30 is formed in a relatively small diameter, a large load is applied in the centrifugation process. Accordingly, the reinforcing ribs 70 are formed around the connection neck 30 to ensure the stability of the device. The reinforcing rib 70 is integrally formed by being connected to the outer circumferential surfaces of the first shoulder 10a, the connection neck 30, the chamber core 21, and the second shoulder 22a.

The reinforcing ribs 70 are formed in plural around the connection neck 30 and are formed in a symmetrical form (two, three, four, etc.).

The first chamber 10, the second chamber 20, and the connection neck 30 are formed to be transparent so that the separation of blood therein can be visually sensed. After centrifugation, the boundary between each component needs to be clearly recognized from the outside, and thus is transparently formed as described above.

3 (a) and 3 (b) are cross-sectional views showing the state of use of the integrated separator 1 shown in FIG. 3 (c) is a sectional view including a block diagram schematically showing an automatic locking device for operating the locking unit 60 shown in FIG.

In the integrated separation device 1 according to a preferred embodiment of the present invention, the upper cover portion 50, the upper cap 51 is coupled to the second chamber 20, the through-hole is formed; It is fixed to the upper cap 51 to seal the through-holes, and made of an injection extraction membrane made of a soft elastic body.

On the contrary, in the integrated separator 1 according to the preferred embodiment of the present invention, the upper cover part 50 is coupled to the second chamber 20, and includes a first through hole 51 a and a second through hole. An upper cap 51 in which a ball 51b is formed; An injection film 52 fixed to the upper cap 51 so as to seal the first through hole 51 a and made of a soft elastic body; It is fixed to the upper cap 51 to seal the second through hole (51b), the extraction membrane 53 made of a soft elastic body; may be made.

In addition, the upper cap 51 is screwed with the second chamber 20.

In the integrated separator 1 according to the preferred embodiment of the present invention, the upper cap 51 may be formed with one through hole or two through holes 51a and 51b. When two through holes are formed, the through holes become the first through hole 51a and the second through hole 51b. In addition, one injection extraction membrane is provided to seal the through hole formed as one, and when the injection hole is formed of two (first through hole 51a and second through hole 51b), the injection film 52 And the extraction membrane 53 is provided separately.

That is, in the upper cap, in order to inject the collected blood into the device 1 and extract the separated blood components, one through hole may be formed (in this case, injection of blood through one injection extraction membrane and Extraction is all made); alternatively, two separate through holes 51a and 51b may be formed. In this case, the injection extraction film has the same shape as the injection film 52 or the extraction film 53.

Hereinafter, for convenience of description, it will be described based on the case where two through holes are formed (injection film 52 and extraction film 53 are provided separately).

The upper cover part 50 includes an upper cap 51, an injection film 52, and an extraction film 53. The upper cap 51 is coupled to the second chamber 20 to occupy most of the upper cover part 50, and is screwed to the second chamber 20. The upper cap 51 seals the upper portion of the second chamber 20 to maintain airtightness.

Coupling grooves 55 are formed at the outer circumference of the upper cap 51. The coupling groove 55 is formed in a 'b' shape (shape in the figure), which is a means for coupling the automatic locking device 80 to be described later. The automatic locking device 80 is provided with a projection inserted into the coupling groove 55, after the projection is fitted into the coupling groove 55 (part made in the vertical direction in the coupling groove 55), one side Rotation in the direction is engaged with each other (part made in the horizontal direction in the coupling groove 55) is to be combined.

The upper cap 51 is formed with the first through hole 51a and the second through hole 51b, wherein the first through hole 51a is collected inside the integrated separator 1 according to the present invention. Corresponds to the passage for injecting blood. However, since the first through hole 51a is sealed by the injection membrane 52, the injection membrane 52 is drilled through the injection membrane 52 using a needle such as a blood injection syringe 100. .

The second through hole 51b is a passage for collecting platelets and the like from blood separated for each component, and is sealed by the extraction membrane 53. Again, the extraction membrane 53 is drilled and extracted using a needle such as a blood extraction syringe 200.

In addition, a guide hole 54 to be described later is formed at the center of the upper cover part 50, and the locking part 60 is supported through the guide hole.

The injection film 52 and the extraction film 53 may be formed in the same shape, and made of a soft elastic body, it is preferably formed of silicon. The injection membrane 52 and the extraction membrane 53 are formed so that the blood inside can be stably maintained during the centrifugal separation process. The injection membrane 52 and the extraction membrane 53 are made of a material such as silicon, and even if a hole is formed in part by the needle of the syringe, proper sealing is achieved. It is guaranteed.

In the integrated separation device 1 according to the preferred embodiment of the present invention, a guide hole 54 is formed at the center of the upper cover part 50, and the locking part 60 is in close contact with the guide hole 54. Locking rod 61 is inserted so as to move up and down; A locking head 62 formed to extend in diameter at an upper end of the locking rod 61; It is formed on the outer circumferential surface of the bottom of the locking rod 61, the locking tip 63 for sealing the inside of the connection neck 30; comprises.

And the pressure hole 64 is formed in the center of the lower end of the locking rod 61 vertically long.

In addition, the integrated separation device 1 according to a preferred embodiment of the present invention includes a control unit 81 for detecting an operation signal, a driving unit 82 for driving in accordance with a signal of the control unit 81, and the driving unit 82. And an automatic locking device (80) comprising a pressing part (83) for pressing the locking head (62) in cooperation with the).

A guide hole 54 is formed at the center of the upper cover part 50 to guide stable locking while the locking part 60 moves up and down. Therefore, the guide hole 54 is formed so that the locking rod 61 of the locking portion 60 may be in close contact and supported.

The locking rod 61 is formed in the form of a long rod up and down, the locking head 62 is formed on the upper side, the locking tip 63 is coupled to the lower side.

The locking head 62 is formed integrally with the locking rod 61, the diameter of the locking rod 61 is formed in the form of the locking rod 61 is lowered so that the locking tip 63 is the inside of the connection neck 30 When sealing, it is formed to be caught on the top of the upper cap (51). After the first centrifugal separation, the inside of the first chamber 10 is filled with red blood cells, wherein the spaces of the first chamber 10 and the second chamber 20 should be separated from each other so as to block each other. The locking tip 63 seals the inside of the connection neck 30, thereby preventing the red blood cells from moving into the second chamber 20. That is, when the first centrifugal separation is made, the locking rod 61 is pushed down by pressing the upper end of the locking head 62, and the blocking of the connection neck 30 by the locking tip 63 is prevented. Will be done.

The locking tip 63 is coupled to the outer circumferential surface of the bottom of the locking rod 61, the diameter is slightly larger than the locking rod 61. The locking tip 63 is preferably made of a material such as silicon, and a plurality of flange-shaped protrusions are formed around the outer circumferential surface so that the sealing of the connection neck 30 can be more stably maintained.

A pressure hole 64 is formed in the center of the lower end of the locking rod 61 vertically. The pressure hole 64 is to prevent the pressure inside the first chamber 10 from being excessively raised, and the locking tip 63 is pushed upward without closing the connection neck 30 as the pressure increases. It is a means to prevent throwing away.

After the first centrifugation is finished, the locking part 60 is pressed down, so that the locking tip 63 is seated on the connecting neck 30 and the space between the first chamber 10 and the second chamber 20. Will block. Thereafter, the second centrifugal separation is performed. During this process, there may be a pressure increase due to a rotational movement in the blood inside the first chamber 10. In this case, the overpressure inside the first chamber 10 is locked. The tip 63 can be pushed upwards. In this case, since the separated blood is mixed again, a means for preventing this is necessary, and the pressure hole 64 is provided so that this problem can be effectively prevented.

An upper portion of the locking rod 61 is provided with an elastic portion (not shown) for supporting the locking rod 61 so as to be fit into the guide hole 54, the elastic portion is the locking rod 61 It is formed integrally with The elastic part is also a means for the locking tip 63 to securely seal the connecting neck 30, and contributes to preventing the above problems.

As described above, when the first centrifugal separation is performed, the locking unit 60 is pressed, and the second centrifugal separation is performed when the space between the first chamber 10 and the second chamber 20 is blocked. . In this process, the operation of pressing the locking unit 60 may be artificially performed, but may be automatically pressed when the first centrifugal separation is completed. That is, by the automatic locking device 80, the first centrifugal separation, the lowering of the locking unit 60, and the first centrifugal separation are continuously performed without human involvement.

The automatic locking device 80 includes a control unit 81, a driving unit 82, and a pressing unit 83.

The pressing part 83 is positioned above the locking head 62 to press and lower the locking head 62. The drive unit 82 is a means for providing power so that the pressing unit 83 is lowered, and consists of a drive motor and a power transmission means.

The controller 81 detects a signal at which the first centrifugal separation ends and operates the driving unit 82. The signal at which the first centrifugation is terminated may be given by a constant time by a timer, or may be given a specific revolution (per revolution) per minute and time. The first centrifugal separation is terminated when it is performed for about 12 minutes at approximately 1800 rpm, and the operating signal is given to the controller 81 under these conditions.

As described above, the upper cover part 50 is provided with an automatic locking device 80 that controls the vertical movement of the locking part 60, so that the second centrifugation is automatically performed after the first centrifugation. It can eliminate the trouble of separation process.

In the integrated separating device 1 according to a preferred embodiment of the present invention, the lower cover portion 40, the lower cap 41 is coupled to the lower edge of the first chamber 10 and provided with a control hole in the center; And an adjuster 43 coupled to the lower cap 41 so as to be movable, and configured to shield the control hole, and to adjust the volume of the inside of the first chamber 10.

The lower cover part 40 may include the lower cap 41 and the adjusting opening 43. That is, the adjustment plate 42 to be described later may be excluded, and the lower cap 41 and the adjustment opening 43 may be formed in the form. The adjustment port 43 is made to seal the lower end of the first chamber 10 by shielding the control hole, it is screwed to the lower cap 41 to move up and down. By adjusting the volume of the adjusting chamber 43 to adjust the volume inside the first chamber 10, the lower cap 41 and the adjusting device 43 will be described in detail later.

4 is a use state diagram showing the integrated separation device 1 shown in FIG.

In the integrated separating device 1 according to the preferred embodiment of the present invention, the lower cover part 40 is coupled to the lower edge of the first chamber 10 and has a lower adjustment hole (not shown) at the center thereof. Cap 41; A rim is interposed between the first chamber 10 and the lower cap 41 to be in close contact with each other, and a control part 42a for convexly formed at the lower side to shield the control hole is provided, and an adjustment plate made of an elastic body ( 42); Located on the lower side of the control plate 42 is coupled to the lower cap 41 so as to be movable, the control port 43 is formed to press the control unit (42a); comprises.

In addition, the adjuster 43 and the lower cap 41 is screwed.

The lower cover part 40 is coupled to the lower side of the first chamber 10 and is formed to adjust a volume inside the first chamber 10. The first chamber 10 is formed in a cylindrical shape with a lower end completely opened, and the lower cover part 40 forms a bottom surface of the first chamber 10.

The lower cover portion 40 is composed of a lower cap 41, the adjusting plate 42 and the adjusting opening 43, the adjusting plate 42 and the adjusting opening 43 is the lower cap 41 by the lower cap 41 It is coupled to the cover 40.

The lower cap 41 is formed in a cylindrical shape with an open center, and is screwed to the lower cover part 40. The central opening of the lower cap 41 corresponds to the control hole (not shown), and the control part 42a of the control plate 42 is located in the control hole. The adjuster 43 is also screwed to the lower cap 41, and thus the lower cap 41 is formed with two screw coupling portions.

The adjusting plate 42 is fitted between the lower cap 41 and the lower edge of the first chamber 10 to fix the lower end of the first chamber 10. The control plate 42 is made of a soft elastic body, it is preferably formed of silicon. The control plate 42 is made of a cylindrical shape so that the rim is in close contact with the inner surface of the first chamber 10, the center is made of a hemispherical shape convex downward. The rim of the control plate 42 is supported and fixed by the first chamber 10 and the lower cap 41, but the center of the control plate 42 is made of a variable shape and by the control opening 43 You can move up and down.

The adjustment port 43 is screwed to the lower cap 41 is formed to move up and down relative to the lower cap 41, it is located below the control plate 42. Preferably, the upper end of the adjuster 43 is formed to be located directly below the center of the control plate 42.

The lower portion of the center of the control opening 43 is formed with a plate-shaped handle exposed to the outside, it can be elevated by rotating the handle.

As the control port 43 moves upward, the center lower portion of the control plate 42 is pressed, and the center of the control plate 42 is pushed upward.

When the first centrifugal separation is completed, only the red blood cell portion of the blood should be located inside the first chamber 10, and when the platelet formed layer is located, it is difficult to separate. In the present invention, in order to solve this problem and to achieve precise separation of platelets, the lower cover part 40 is configured to have the configuration as described above. ) To adjust the internal volume.

That is, the control unit 43 is rotated so that the boundary between the erythrocytes and platelets is adjacent to the upper end of the first chamber 10, and the locking unit 60 is lowered so as to lower the locking unit 60 and the first chamber 10. The space between the second chambers 20 is separated so that the platelet layer can be effectively separated from the erythrocyte layer.

As such, the lower cover part 40 is made of the control plate 42 and the control port 43 to adjust the volume of the inside of the first chamber 10, so that the amount of blood injected or separated According to the blood component ratio, platelets can be separated very accurately, and excellent quality PRP can be obtained.

1: Integral Separator 10: First Chamber
10a: first shoulder 20: second chamber
21: chamber core 21a: core shoulder
22: chamber body 22a: second shoulder
30: connection neck 40: lower cover
41: lower cap 42: throttle
42a: adjuster 43: adjuster
50: upper cover part 51: upper cap
51a: through-hole 1 51b: through-hole 2
52: injection film 53: extraction film
54: guide hole 55: coupling groove
60: locking portion 61: locking rod
62: locking head 63: locking tip
64: pressure hole 70: reinforcing rib
80: automatic locking device
100: injection syringe 200: extraction syringe

Claims (18)

In the separation device used to separate a specific component from a mixture of components having different specific gravity,
A first chamber formed at a lower side and configured to accommodate a portion of the mixed material therein;
A second chamber formed at an upper side and communicating with the first chamber to accommodate a portion of the mixed material therein;
A connecting neck integrally formed between the first chamber and the second chamber;
A lower cover part formed to seal a lower side of the first chamber;
An upper cover part formed to seal an upper side of the second chamber; And
The lower cover part or the upper cover part is supported to be moved up and down based on the lower cover part or the upper cover part, and the inside of the connection neck is sealed to allow the mixed material to form the first chamber and the second chamber. Integral separation device comprising a; locking portion to prevent movement between.
The method of claim 1,
The connecting neck is an integral separation device, characterized in that the diameter is formed narrower than the first chamber and the second chamber.
The method of claim 2, wherein the second chamber,
A chamber core formed adjacent to the connection neck and smaller in diameter than the first chamber and larger in diameter than the connection neck; And
The chamber core is formed on the upper side of the chamber core, the diameter is formed larger; integral separation device characterized in that consisting of.

The method of claim 3, wherein
Some of the chamber core is tapered at the portion connected to the connecting neck to form a core shoulder.

The method of claim 4, wherein
And a portion of the chamber body is tapered at a portion subsequent to the chamber core to form a second shoulder.

The method of claim 2,
And a portion of the first chamber is tapered at a portion connected to the connection neck to form a first shoulder.
The method of claim 2,
And a reinforcing rib formed on an outer circumferential surface of the connection neck and connected to the first chamber and the second chamber to be integrally formed.
The method of claim 1,
The first chamber, the second chamber and the connecting neck is an integral separation device, characterized in that made transparent.
The method of claim 1, wherein the upper cover portion,
An upper cap coupled to the second chamber and having a through hole formed therein;
And an injection extraction membrane fixed to the upper cap so as to seal the through hole and made of a soft elastic body.
The method of claim 1, wherein the upper cover portion,
An upper cap coupled to the second chamber and having a first through hole and a second through hole formed therein;
An injection membrane fixed to the upper cap to seal the first through hole and made of a soft elastic body; an extraction membrane fixed to the upper cap to seal the second through hole and made of a soft elastic body; Integral separation device, characterized in that.
The method according to claim 9 or 10,
And the upper cap is screwed with the second chamber.
The method of claim 1,
A guide hole is formed in the center of the upper cover part,
The locking unit,
A locking rod which is fitted in close contact with the guide hole and moves up and down;
A locking head formed to expand in diameter at an upper end of the locking rod;
And a locking tip formed on an outer circumferential surface of the locking rod bottom and sealing the inside of the connection neck.
The method of claim 12,
Integrated locking device, characterized in that the pressure hole is formed in the center of the bottom of the locking rod long vertically.
The method of claim 12,
And an automatic locking device including a control unit for detecting an operation signal, a driving unit driving according to the signal of the control unit, and a pressing unit for pressing the locking head in cooperation with the driving unit. Device.
The method of claim 1, wherein the lower cover portion,
A lower cap coupled to the lower edge of the first chamber and provided with a control hole at a center thereof; And
And a control mechanism coupled to the lower cap so as to be movable, and configured to shield the control hole.
Integral separation device, characterized in that made to be able to adjust the volume inside the first chamber.
The method of claim 1, wherein the lower cover portion,
A lower cap coupled to the lower edge of the first chamber and provided with a control hole at a center thereof;
An rim is interposed between the first chamber and the lower cap to be in close contact with each other, and is formed to be convex downward in the center thereof to provide an adjustment part for shielding the adjustment hole, and an adjustment plate made of an elastic body;
An integrated separating device comprising a; is located on the lower side of the control panel coupled to the lower cap so as to be movable, the control port is formed to press the control unit.
The method according to claim 15 or 16,
The control unit and the lower cap is integrally separated device characterized in that the screwed.
The method of claim 1,
Integral separation device, characterized in that the mixed material is blood.

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