KR20140069789A - Composition comprising Opuntia compressa J.F. Macbr. extract for food ingredient of arthritis function as an effective component - Google Patents
Composition comprising Opuntia compressa J.F. Macbr. extract for food ingredient of arthritis function as an effective component Download PDFInfo
- Publication number
- KR20140069789A KR20140069789A KR1020120137503A KR20120137503A KR20140069789A KR 20140069789 A KR20140069789 A KR 20140069789A KR 1020120137503 A KR1020120137503 A KR 1020120137503A KR 20120137503 A KR20120137503 A KR 20120137503A KR 20140069789 A KR20140069789 A KR 20140069789A
- Authority
- KR
- South Korea
- Prior art keywords
- extract
- water
- root
- ethanol
- food composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- 235000000039 Opuntia compressa Nutrition 0.000 title abstract 3
- 206010003246 arthritis Diseases 0.000 title description 10
- 239000005417 food ingredient Substances 0.000 title description 2
- 244000106264 Opuntia compressa Species 0.000 title 1
- 235000012041 food component Nutrition 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 235000013305 food Nutrition 0.000 claims abstract description 24
- 230000008407 joint function Effects 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 238000000605 extraction Methods 0.000 claims abstract description 16
- 238000010438 heat treatment Methods 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 8
- 239000002904 solvent Substances 0.000 claims abstract description 7
- 239000012141 concentrate Substances 0.000 claims abstract description 6
- 239000000706 filtrate Substances 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- 238000001704 evaporation Methods 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 16
- 239000011575 calcium Substances 0.000 claims description 16
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 239000001963 growth medium Substances 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 3
- 235000007810 Eryngium campestre Nutrition 0.000 claims description 2
- 244000233952 Polygonum bistorta Species 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 235000018984 snakeroot Nutrition 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims 2
- 241001480065 Quercus serrata Species 0.000 claims 1
- 230000000249 desinfective effect Effects 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 abstract description 5
- 241000454613 Opuntia humifusa Species 0.000 abstract 2
- 238000010792 warming Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 235000013376 functional food Nutrition 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 239000003814 drug Substances 0.000 description 5
- 206010039073 rheumatoid arthritis Diseases 0.000 description 5
- 208000001132 Osteoporosis Diseases 0.000 description 4
- 230000037180 bone health Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 201000008482 osteoarthritis Diseases 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 210000001188 articular cartilage Anatomy 0.000 description 3
- 230000005786 degenerative changes Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 229930014626 natural product Natural products 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000001513 elbow Anatomy 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000012046 mixed solvent Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 241001133760 Acoelorraphe Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000219357 Cactaceae Species 0.000 description 1
- 102000004225 Cathepsin B Human genes 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 102000003908 Cathepsin D Human genes 0.000 description 1
- 108090000258 Cathepsin D Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010023230 Joint stiffness Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010041899 Stab wound Diseases 0.000 description 1
- 208000013201 Stress fracture Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- CPGKMLVTFNUAHL-UHFFFAOYSA-N [Ca].[Ca] Chemical compound [Ca].[Ca] CPGKMLVTFNUAHL-UHFFFAOYSA-N 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 210000003321 cartilage cell Anatomy 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/316—Foods, ingredients or supplements having a functional effect on health having an effect on regeneration or building of ligaments or muscles
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/10—Drying, dehydrating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
본 발명은 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물 및 그 제조방법에 관한 것으로, 보다 구체적으로는 칼슘이 풍부하고 종양 괴사인자-알파(TNF-α)의 유리를 억제하여 관절기능에 도움이 될 수 있도록 한 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물 및 그 제조방법에 관한 것이다.The present invention relates to a food composition for improving joint function and a method for producing the same, more specifically, a composition rich in calcium and inhibiting the release of tumor necrosis factor-alpha (TNF-α) To a food composition for improving joint function and a method for producing the same.
관절염이란 관절에 어떤 원인에 의해서든 염증성 변화가 생긴 것을 총괄해서 지칭하는 병명으로 주로 나이가 들면서 발생한다. 정확한 증상으로는 뼈와 뼈 마디의 연결부위의 물렁뼈가 소실되는 퇴행성 관절염과 자가면역 질환인 류마티스 관절염으로 분류할 수 있다. Arthritis is a disease that refers to allergic inflammatory changes in the joints caused by any cause. Exact symptoms include degenerative arthritis in which the soft bones of the joints of bone and bone segments disappear, and rheumatoid arthritis, an autoimmune disease.
퇴행성 관절염은 관절 연골이 닳아 없어지면서 국소적인 퇴행성 변화가 나타나는 질환이며, 이 질환에서는 관절 연골의 퇴행성 변화가 일차적으로 나타난다. 나이가 많아질수록 여성에게서 더 많이, 그 정도도 심하게 나타난다. Degenerative arthritis is a disease in which degenerative changes occur locally as the articular cartilage is worn out. Degenerative changes of articular cartilage occur primarily in this disease. As you get older, you get more and more from women.
원인이 분명하지 않은 경우에 원발성이라 하고 어떤 원인에 속발된 때에는 이차성으로 구분한다. 점차 원인질환이 확정되어 가는 경향이므로 결국 대부분의 퇴행성 관절염은 이차성에 속하게 될 것이다. If the cause is unclear, it is called primary. If it is secondary to any cause, it is classified as secondary. Since the cause of the disease gradually tends to become definite, most degenerative arthritis will eventually belong to secondary.
퇴행성 변화는 관절 연골에서 시작되며 연골 세포와 기질이 파괴되고, 이때 기질은 Cathepsin B, Cathepsin D, Collagenase 등에 의해 파괴된다. Proteoplycan과 Collagen의 생선은 파괴정도를 따라가지 못하며 외력에 대한 연골의 적응 능력은 점점 감소하여 결국 연골하골 조직에 미세골절 등의 소견이 생기고 악순환이 계속되며, 따라서 현재까지는 노화현상의 일종이며, 과체중이 원인으로 지목되고 있다. Degenerative changes start from articular cartilage, cartilage cells and matrix are destroyed, and the matrix is destroyed by Cathepsin B, Cathepsin D, Collagenase, etc. Proteoplycan and collagen fish can not follow the degree of destruction and the ability of the cartilage to adapt to external forces gradually decreases, resulting in microfracture and other malformations in the cartilaginous tissues and vicious cycle. Thus, until now, it is a kind of aging phenomenon, This is attributed to this cause.
류마티스 관절염의 자가면역 질환으로서 유전적인 요소는 손가락 원위 지관절에 생기는 Herberden's node이외에 별다른 가족력이 없고 비만과의 연관은 대개 체중부하 관절에 많은 점으로 인정되고 있다. 노인 연령에 증가하며 45세 이하에서는 다소 남자에게 많고 폐경기 이후에는 여자에게 많다. The genetic component of rheumatoid arthritis is a hereditary factor that has no family history other than Herber's's node in the distal fingertip of the finger, and its association with obesity is often recognized as a burden on weight-bearing joints. It increases with the age of the elderly, and it is somewhat male-like when it is under 45 years old, and there are many after menopause.
잘 침범되는 관절은 손가락, 손목, 팔꿈치, 무릎, 발가락 같은 관절이며 턱관절이나 목관절에도 올 수가 있다. 여러 개의 관절이 갑자기 부어오르며 동통을 느끼게 되는 경우에서부터 수년에 걸쳐 서서히 관절의 강직과 변형이 초래되는 등 차이가 많다. 특징적인 것으로는 관절이 뻣뻣해지는 것으로 특히 아침에 심하다. 처음에는 주로 양쪽 손의 손가락 마디 관절, 발의 작은 관절, 팔꿈치 등에서 부종과 열감, 동통을 느끼며 시작되나 점차적으로 시간이 오래되면 슬관절, 고관절 등의 커다란 관절에도 증상이 나타난다. Well-invasive joints are joints such as fingers, wrists, elbows, knees, and toes, and can come to the jaw joints or neck joints. There are many differences, such as the sudden swelling of joints, pain, and a gradual increase in joint stiffness and deformation over the years. Characteristic is that the joint becomes stiff, especially in the morning. Initially, it begins to feel swelling, fever, and pain in the joints of the fingertips of both hands, the small joints of the feet, and the elbows. However, gradually over time, symptoms may also occur in the joints such as the knee and hip.
특히 아침에 일어났을 때 관절 마디가 뻣뻣해서 움직이기 힘든 현상이 양쪽 관절에 대칭적으로 1시간 이상 지속되면 류마티스 관절염을 의심해 보아야 한다.In particular, if the phenomenon in which the joints are stiff and difficult to move when waking up in the morning persists symmetrically for more than one hour on both joints, you should suspect rheumatoid arthritis.
전반적으로 관절염을 예방하거나 치료하는 방법은 여러 가지가 있는데 생활습관을 개선하여 체중을 줄이거나 무리한 달리기와 무릎에 무리가는 운동을 줄이며 적절한 운동으로 관절의 유연성을 향상시킨다. 또한 약물로는 초기에는 글루코사민부터 콘드로이친 황산을 사용하지만 조금 증상이 진행되면 비스테로이성 항소염제(NSAID)를 사용하지만 질병 자체가 장기적으로 진행되기 때문에 사람에 따라 오히려 부작용으로 고통이 따른다.Overall, there are many ways to prevent or treat arthritis. Improve your lifestyle to reduce your weight, reduce unnecessary exercises and running over your knees, and improve your flexibility with proper exercise. As a drug, initially glucosamine to chondroitin sulfuric acid is used, but when the symptoms are slightly advanced, the NSAID is used, but the disease itself is long-term, so it is a side effect depending on the person.
특히 류마티스 관절염은 현재까지는 관절염의 근본적인 치료는 불가능하고 일시적으로 통증을 완화하고 염증을 억제하는 방향으로 진행되고 있는데, 류마티스 관절염은 만성 염증성 질환과 T-세포 매개의 면역 시스템 질환으로 분류되기 때문에 예방이나 치료제를 개발하기 위해서는 염증과 관련된 사이토카인의 유리를 억제시키고, 활성화된 T 세포만을 선택적으로 사멸할 수 있는 약제의 개발이 요구되고 있다.In particular, rheumatoid arthritis is currently unable to treat arthritis fundamentally and is temporarily progressing to relieve pain and suppress inflammation. Since rheumatoid arthritis is classified as chronic inflammatory disease and T-cell mediated immune system disease, In order to develop a therapeutic agent, development of a drug capable of inhibiting the release of cytokines related to inflammation and selectively killing activated T cells is required.
그러나 관절염은 전반적으로 노화과정의 산물로 볼 수 있기 때문에 심각한 중증의 병증을 제외하고는 한번 발병하면 평생 관리하며 지내야 하므로 장기적인 약물사용은 부작용이 동반될 수 있어 어느 질병보다 증세를 완화시키며 오랫동안 사용할 수 있는 식품소재에 대한 관심이 높은 질병이다. 또한 관절염을 가지고 있는 환자는 대부분 뼈 건강에 문제가 있는 골소실증 또는 골다공증 환자이기 때문에 식품으로서는 염증완화와 함께 충분한 칼슘의 보충도 중요하다. However, arthritis is a product of the aging process as a whole. Except for serious severe illness, once a disease develops, it should be managed for a lifetime, so long-term use of drugs may be accompanied by side effects. It is a disease which is interested in the food material. In addition, since most patients with arthritis are suffering from osteoporosis or osteoporosis, which is problematic in bone health, sufficient calcium supplementation with inflammation relief is important as food.
본 발명자들은 식용으로 사용하는 천년초 뿌리 추출물이 괴사인자-알파(TNF-α)의 유리를 억제시키고 다른 식물보다도 월등히 높은 고함량의 칼슘이 함유되어 있으므로 이를 이용한 관절기능에 좋은 식품소재를 개발할 수 있음을 확인하였다. The inventors of the present invention can develop a food material having a good joint function using the nutrient factor-alpha (TNF-alpha) inhibitory effect and the high content of calcium, which is much higher than other plants, Respectively.
본 발명의 목적은 상기의 문제점들을 해결하기 위하여 안출된 것으로, 천년초의 뿌리를 활용하여 관절기능을 월등히 개선할 수 있도록 한 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물 및 그 제조방법을 제공하는 데 있다.DISCLOSURE OF THE INVENTION An object of the present invention is to solve the above problems and provide a food composition for improving joint function and a method for manufacturing the same, which comprises an effective ingredient of a perennial herb extract .
본 발명의 다른 목적은 장기간 섭취해도 부작용이 전혀 없는 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물 및 그 제조방법을 제공하는 데 있다.It is another object of the present invention to provide a food composition for improving joint function, which comprises an effective ingredient of a tsunami extract, which has no side effects even if taken for a long period of time, and a method for producing the same.
본 발명의 또 다른 목적은 천년초 추출물을 획득하기 위하여 생물배양기를 이용하여 배양한 배양근을 건조시킨 후 분말을 그대로 사용할 수 있도록 한 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물 및 그 제조방법을 제공하는 데 있다.It is still another object of the present invention to provide a food composition for improving joint function and a method for preparing the composition for improving joint function, which comprises an effective ingredient of a tsunami extract which can be used as it is after drying a cultured muscle cultured using a biological incubator .
상기 목적을 달성하기 위하여, 본 발명에 따른 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물을 특징으로 한다.
In order to attain the above object, the present invention provides a food composition for improving joint function, which comprises the tsunami extract of the present invention as an active ingredient.
본 발명의 일 실시예에 따른 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물의 제조방법은, 천년초 뿌리를 물로 세척한 후 추출용기에 투입하는 단계; 추출용기에 물, 에탄올(주정) 또는 물과 에탄올(주정)이 혼합된 용매를 투입하는 단계; 추출용기를 가열하여 8시간 동안 가온추출하는 단계; 추출물을 여과하는 단계; 여과물을 증발기에서 증발시켜 농축하는 단계; 및 농축물을 건조하여 분말화하는 단계;를 포함하는 것을 특징으로 한다.
A method for preparing a food composition for improving joint function, comprising a quinine-kernel extract according to an embodiment of the present invention as an active ingredient, comprises: washing the root of the root with water; Introducing a solvent in which water, ethanol (alcohol), or water and ethanol (alcohol) are mixed into an extraction vessel; Heating the extraction vessel and heating for 8 hours; Filtering the extract; Evaporating the filtrate in an evaporator and concentrating; And drying and pulverizing the concentrate.
본 발명의 다른 실시예에 따른 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물의 제조방법은, 천년초 뿌리로부터 조직을 절편하여 소독하는 단계; 소독한 천년초 뿌리 조직을 생물배양기에 투입하는 단계; 생물배양기에 수용성 칼슘 2%를 첨가한 후 천년초 뿌리 조직을 배양액에서 60일간 조직배양하는 단계; 배양된 배양근과 물, 에탄올(주정) 또는 물과 에탄올(주정)이 혼합된 용매를 추출용기에 투입하는 단계; 추출용기를 가열하여 8시간 동안 가온추출하는 단계; 추출물을 여과하는 단계; 여과물을 증발기에서 증발시켜 농축하는 단계; 및 농축물을 건조하여 분말화하는 단계;를 포함하는 것을 특징으로 한다.A method for preparing a food composition for improving joint function, which comprises as an active ingredient an extract of Cheonjangwon-do according to another embodiment of the present invention comprises the steps of: Introducing the sterilized root tissue of the snake root into a biological incubator; Adding 2% of water-soluble calcium to the bio-incubator, and then culturing the root tissue of the tubercle tissue in the culture medium for 60 days; Introducing into the extraction vessel a solvent in which the culture medium and water are mixed with ethanol (alcohol) or water and ethanol (alcohol); Heating the extraction vessel and heating for 8 hours; Filtering the extract; Evaporating the filtrate in an evaporator and concentrating; And drying and pulverizing the concentrate.
상술한 바와 같이, 본 발명에 따른 천년초 추출물을 함유하는 관절기능 식품소재 조성물 및 그 제조방법에 의하면, 관절 기능 뿐만 아니라 뼈 건강 건강기능식품의 소재로도 이용이 가능하다.As described above, according to the functional food composition and the method for producing the same, the composition of the present invention can be used not only as a joint function but also as a material for a bone health health functional food.
특히 관절염은 대부분 노년층에서 발병하므로 생활의 불편이 크며, 상대적으로 사회활동을 위축시켜 심리적으로도 큰 고통을 동반하기 때문에 천연물을 이용한 관절기능 식품소재 개발은 의약품 이상의 가치를 가질 수 있다.In particular, arthritis is mostly caused by elderly people, so it is difficult for people to live. Therefore, it is more difficult to develop joint functional foods using natural products than medicines.
또한, 본 발명에 따른 천년초 추출물을 함유하는 관절기능 식품소재 조성물 및 그 제조방법은 식용이 가능한 천년초 뿌리 추출물을 이용하여 제조하였으므로 안전성 면에서 매우 적합하다. 따라서 장기간 사용할 수 있는 식품소재 및 건강기능식품의 소재로도 상당히 좋은 효과가 있다.In addition, the functional food composition and the method for manufacturing the joint functional food composition containing the tsunami seed extract according to the present invention are suitable for safety because they are prepared by using edible Chenille seeds root extract. Therefore, it has a considerably good effect as a material for food materials and health functional foods which can be used for a long time.
또한, 본 발명에 따르면 년차가 길어질수록 효과가 높아지는 뿌리를 대량 얻기 위해서는 재배기간이 길어지는 단점이 있지만 생물배양기를 이용한 배양근을 활용하면 기간을 단축시키고, 배양액에 수용성 칼슘 2%를 첨가하여 배양된 배양근은 칼슘함량이 2배 증가하여 관절염과 동반되는 골소실 또는 골다공증인 있는 골관절염에도 효과가 있다.According to the present invention, there is a disadvantage in that the cultivation period is prolonged in order to obtain a large amount of roots having an increased effect as the year is longer. However, when the culture broth using a biological incubator is used, the period is shortened and cultured by adding 2% The cultured muscle is also effective in osteoarthritis with osteoporosis or osteoporosis accompanied by arthritis by a twofold increase in calcium content.
도 1은 본 발명에 따른 천년초 추출물을 함유하는 관절 기능 개선용 식품 조성물을 제조하기 위한 추출 방법을 설명하는 도면이다.
도 2는 본 발명에 따른 고칼슘 천년초 배양근을 제조하여 분말화한 관절기능 개선용 식품 조성물의 제조 공정을 설명하기 위한 도면이다.FIG. 1 is a view for explaining an extraction method for preparing a food composition for improving joint function, which comprises a tsunami extract of the present invention.
FIG. 2 is a diagram for explaining a process for producing a food composition for improving joint function by preparing a high-calcium millennium culture rod according to the present invention and pulverizing it.
본 발명은 안전성이 높은 천년초를 이용하여 관절기능 개선용 식품소재를 개발하려는 것으로, 장기간 섭취해도 부작용이 없는 장점이 있다. 관절염은 대부분의 노인에서 발병하는 질환으로 활동이 불편하여 운동이 부족하고, 이런 반복적인 현상은 결국 관절의 약화와 더불어 뼈 건강에도 영향을 미치기 때문에 천년초를 이용한 관절기능 개선용 식품소재는 노인성 질환인 관절염에 매우 유용한 소재인 것이다.The present invention is to develop a food material for improving joint function by using high-safety millennia, and it has an advantage that there is no side effect even if it is ingested for a long time. Arthritis is a disease that occurs in most elderly people and is inadequate to exercise. Therefore, this repetitive phenomenon eventually affects bone health as well as joint weakness. Therefore, It is a very useful material for arthritis.
본 발명에서 사용하는 천년초는 장기적으로 사용된 식용의 선례가 있는 약용식물로서 매우 안전성이 높은 단일 천연물이며, 기존에 단일 천연물로서 동일한 질병에 사용된 전례가 없는 것이다.The present invention relates to a medicinal herb that is used in the present invention for a long period of time, and is a highly safe, single natural product, and has never been used in the same disease as a single natural product.
또한, 본 발명에 따른 천년초 추출물을 함유하는 관절기능 개선용 식품 조성물은 식용이 가능하나 특유의 매우 쓴맛으로 인하여 섭취가 어려운 점을 개선하여 적합하게 제조되었다.In addition, the food composition for improving joint function containing the tsunami extract of the present invention can be edible but is suitably prepared by improving its difficulty in ingestion due to its unique bitter taste.
또한, 본 발명에 따른 천년초 추출물은 뿌리의 년차가 길어질수록 약효가 증가하나 대량으로 얻기 위해서는 오랜 기간과 재배면적의 확보에 어려움이 있으나, 생물배양기를 이용한 배양근을 사용하면 기간을 줄일 수 있으며, 아울러 배양근 제조 시에는 수용성 칼슘 2%를 첨가하여 칼슘 함량이 2배 높은 고칼슘 배양근을 얻을 수 있다.In addition, the long-term root extract of the present invention has an increased efficacy as the annual root length thereof is increased. However, it is difficult to secure a cultivation area for a long period of time in order to obtain a large amount. However, In the preparation of the cultured root, 2% of water soluble calcium is added to obtain a high calcium calcium root having a calcium content two times higher.
국내에서 식용 및 약용으로 널리 사용되는 천년초는 한국 토종 손바닥 선인장으로 영하 30℃의 혹한과 영상 40℃에서도 생명력을 키우는 강인한 식물로 화상, 자상 및 각종 피부염에 사용되어 왔으며, 이외에도 해열진정, 기관지천식, 소화불량과 당뇨와 고지혈증에도 효과가 있는 것으로 보고되어 있다. 천년초의 성분은 식이섬유와 플라보노이드가 주요 성분이며, 비타민 C와 특히 칼슘의 함량이 풍부하다.
It is widely used in Korea for edible and medicinal purposes. It is a Korean native palm cactus. It is a strong plant that grows vitality at temperatures of minus 30 degrees Celsius and 40 degrees Celsius. It has been used for burns, stab wounds and various dermatitis. It has also been reported to be effective in indigestion, diabetes and hyperlipidemia. Ingredients of the millennium are dietary fiber and flavonoids, and are rich in vitamin C and especially calcium.
이하, 첨부된 도면을 참조하여 본 발명에 따른 천년초 추출물을 함유하는 관절 기능 개선용 식품 조성물 및 그 제조방법에 대하여 상세히 설명한다.Hereinafter, a food composition for improving joint function and a method of manufacturing the same will be described in detail with reference to the accompanying drawings.
먼저, 천년초 추출물을 함유하는 관절기능 개선용 식품 조성물을 제조방법에 대해 도 1에 따라 설명한다.First, a method of manufacturing a food composition for improving joint function containing a tsunami extract will be described with reference to Fig.
도 1은 본 발명에 따른 천년초 추출물을 함유하는 관절기능 식품소재 조성물을 제조하기 위한 방법을 설명하는 도면이다.BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a view for explaining a method for producing a functional food ingredient composition containing a tsunami extract of the present invention. FIG.
도 1에 도시된 바와 같이, 가온 추출에 사용하는 용매는 물, 에탄올(주정) 또는 물과 에탄올(주정)이 혼합된 용매를 모두 사용할 수 있다. 혼합용매 사용 시에는 물과 알코올(또는 주정)의 배합 비율은 7 : 3이 적절하다.As shown in Fig. 1, the solvent used for warm-up extraction may be water, ethanol (alcohol), or a solvent in which water and ethanol (alcohol) are mixed. When using mixed solvents, the mixing ratio of water to alcohol (or alcohol) is preferably 7: 3.
먼저, 천년초 뿌리를 물로 깨끗이 세척한 후 추출용기에 투입하고, 투입된 천년초의 8 ∼ 10 배의 물, 알코올(또는 주정) 또는 혼합용매(주정과 정제수)로 8시간 동안 추출한다. 상기 추출물은 여과되고, 증발기 등을 이용하여 농축된다. 이 후, 건조 공정을 거처 분말화하고, 품질검사를 하여 포장한다.
First, the root of the matured seedlings is thoroughly washed with water, put into an extraction vessel, and extracted with 8 to 10 times of water, alcohol (or alcohol) or mixed solvent (alcoholic beverage and purified water) for 8 hours. The extract is filtered and concentrated using an evaporator or the like. Thereafter, the product is pulverized by a drying process, and quality inspection is carried out.
또한, 도 2에 따라 본 발명에 따른 천년초 추출물은 생물배양기를 이용한 칼슘함량이 2배 높은 고칼슘 배양근의 제조와 분말의 제조에 대해 설명한다.In addition, referring to FIG. 2, the present invention provides a preparation of a calcium-containing high-calcium growth muscle having a calcium content two times higher than that of a calcium-containing culture medium,
먼저, 천년초 뿌리로부터 조직을 절편하여 소독 후에 생물배양기에 수용성 칼슘 2%가 첨가된 배양액에서 60일간 조직배양 후 여과, 건조 후 분말화하여 포장한다.First, the tissues are cut from the tubercle roots and disinfected. The tissue culture is performed for 60 days in a culture medium in which 2% of water-soluble calcium is added to a biological incubator, followed by filtration, drying and powdering.
상기 조직배양된 배양근을 상기에 기술된 제조방법에 따라 추출물을 추출하여 관절기능 개선용 식품 조성물을 제조할 수 있다.The food composition for improving joint function can be prepared by extracting the extract according to the above-described manufacturing method of the tissue culture root.
또한 본 발명에서 추출물의 분말화는 용량에 따라 스프레이 드라이(spray dry), 동결건조(freeze dry) 방식 등으로 할 수 있으며, 최종적으로는 잔류농약, 중금속, 미생물 검사 등을 실시한다.
In the present invention, the pulverization of the extract can be carried out by spray drying, freeze drying or the like depending on the volume. Finally, residual pesticides, heavy metals and microorganisms are tested.
본 발명에 따른 천년초 추출물을 함유하는 관절기능 조성물 및 그 제조방법은 다양한 식품소재 및 화장품에도 활용할 수 있다.The functional composition for joints containing the tsunami extract of the present invention and the preparation method thereof can be applied to various food materials and cosmetics.
본 발명에 따른 생물배양기를 이용한 고칼슘 배양근은 뼈건강 소재로도 활용할 수 있다.
The high calcium growth muscle using the bio-incubator according to the present invention can also be utilized as a bone health material.
본 발명의 권리범위는 위에서 설명된 실시 예에 한정되지 않고 청구범위에 기재된 바에 의해 정의되며, 본 발명의 기술분야에서 통상의 지식을 가진 자가 청구범위에 기재된 권리범위 내에서 다양한 변형과 개작을 할 수 있다는 것은 자명하다.
The scope of the present invention is not limited to the embodiments described above, but may be defined by the scope of the claims, and those skilled in the art may make various modifications and alterations within the scope of the claims It is self-evident.
Claims (3)
추출용기에 물, 에탄올(주정) 또는 물과 에탄올(주정)이 혼합된 용매를 투입하는 단계;
추출용기를 가열하여 8시간 동안 가온추출하는 단계;
추출물을 여과하는 단계;
여과물을 증발기에서 증발시켜 농축하는 단계; 및
농축물을 건조하여 분말화하는 단계;를 포함하는 것을 특징으로 하는 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물의 제조방법.Washing the tubercle root with water and introducing it into an extraction vessel;
Introducing a solvent in which water, ethanol (alcohol), or water and ethanol (alcohol) are mixed into an extraction vessel;
Heating the extraction vessel and heating for 8 hours;
Filtering the extract;
Evaporating the filtrate in an evaporator and concentrating; And
And drying and concentrating the concentrate to form a powder. The method for manufacturing a food composition for improving joint function according to claim 1,
소독한 천년초 뿌리 조직을 생물배양기에 투입하는 단계;
생물배양기에 수용성 칼슘 2%를 첨가한 후 천년초 뿌리 조직을 배양액에서 60일간 조직배양하는 단계;
배양된 배양근과 물, 에탄올(주정) 또는 물과 에탄올(주정)이 혼합된 용매를 추출용기에 투입하는 단계;
추출용기를 가열하여 8시간 동안 가온추출하는 단계;
추출물을 여과하는 단계;
여과물을 증발기에서 증발시켜 농축하는 단계; 및
농축물을 건조하여 분말화하는 단계;를 포함하는 것을 특징으로 하는 천년초 추출물을 유효성분으로 함유하는 관절기능 개선용 식품 조성물의 제조방법.
A step of cutting and disinfecting the tissue from the root of the plant;
Introducing the sterilized root tissue of the snake root into a biological incubator;
Adding 2% of water-soluble calcium to the bio-incubator, and then culturing the root tissue of the tubercle tissue in the culture medium for 60 days;
Introducing into the extraction vessel a solvent in which the culture medium and water are mixed with ethanol (alcohol) or water and ethanol (alcohol);
Heating the extraction vessel and heating for 8 hours;
Filtering the extract;
Evaporating the filtrate in an evaporator and concentrating; And
And drying and concentrating the concentrate to form a powder. The method for manufacturing a food composition for improving joint function according to claim 1,
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120137503A KR20140069789A (en) | 2012-11-30 | 2012-11-30 | Composition comprising Opuntia compressa J.F. Macbr. extract for food ingredient of arthritis function as an effective component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020120137503A KR20140069789A (en) | 2012-11-30 | 2012-11-30 | Composition comprising Opuntia compressa J.F. Macbr. extract for food ingredient of arthritis function as an effective component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140069789A true KR20140069789A (en) | 2014-06-10 |
Family
ID=51124814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020120137503A KR20140069789A (en) | 2012-11-30 | 2012-11-30 | Composition comprising Opuntia compressa J.F. Macbr. extract for food ingredient of arthritis function as an effective component |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR20140069789A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101578068B1 (en) | 2015-04-08 | 2015-12-16 | 김경일 | Health supplementing food for alleviating symptoms of joint pathologies and a preparation method thereof |
| KR102560440B1 (en) | 2022-03-28 | 2023-07-28 | 신현제 | Health functional food composition for improving joint health and manufacturing method thereof |
-
2012
- 2012-11-30 KR KR1020120137503A patent/KR20140069789A/en not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101578068B1 (en) | 2015-04-08 | 2015-12-16 | 김경일 | Health supplementing food for alleviating symptoms of joint pathologies and a preparation method thereof |
| KR102560440B1 (en) | 2022-03-28 | 2023-07-28 | 신현제 | Health functional food composition for improving joint health and manufacturing method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Boshra et al. | Papaya-an innovative raw material for food and pharmaceutical processing industry | |
| Lans et al. | Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada | |
| Gade et al. | Seaweeds: a novel biomaterial | |
| Okwu et al. | Evaluation of the chemical composition of Dacryodes edulis and Raphia hookeri Mann and Wendl exudates used in herbal medicine in south eastern Nigeria | |
| Mathivanan et al. | Morinda pubescens JE Smith (Morinda tinctoria Roxb.) fruit extract accelerates wound healing in rats | |
| CN104096047A (en) | Externally-applied detoxification ointment for treatment of poisonous snake bite wound and preparation method thereof | |
| KR101740028B1 (en) | Composition for preventing, improving, or treating arthritis comprising Achyranthis Japonicae Radix and Scutellariae Radix or Achyranthis Japonicae Radix, Scutellariae Radix and Acanthopanacis Cortex | |
| KR20140069789A (en) | Composition comprising Opuntia compressa J.F. Macbr. extract for food ingredient of arthritis function as an effective component | |
| KR20170143235A (en) | Herbal medicine composition for treatment of osteoarthritis and cartilage regeneration | |
| KR20200118322A (en) | Cleanser for women and methods for manufacturing the same | |
| CN104288055A (en) | Chinese herbal medicine composition containing saussurea medusa as well as preparation method and application of Chinese herbal medicine composition | |
| KR20180126691A (en) | Oriental pills for the prevention, improvement or treatment of arthritis and methods for producing the same | |
| JP2006225297A (en) | Agent for treating/preventing obesity, hyperlipemia and arteriosclerotic disease | |
| KR101423316B1 (en) | Composition for prevention or treatment of osteoarthritis including extracts of Phyllanthus tenellus | |
| KR100543082B1 (en) | A manufacturing process of composition for reducing the body weight and cholesterol | |
| KR20110016825A (en) | Composition for prevention or treatment of arthritis comprising the complex herb extract of schisandra chinensis bail, scutellaria baicalensis and kalopanax pictus nakai | |
| JP5279946B1 (en) | Joint pain remedy | |
| KR101248378B1 (en) | Pharmaceutical composition for arthritis treatment and prevention | |
| Torres et al. | Ethnobotanical uses and potential pharmaceutical applications of the Cactaceae family | |
| JP6861955B2 (en) | Hyaluronic acid synthesis accelerator | |
| Raja et al. | A scientific evidence-based review of tamarind usage in Indian folklore medicine. | |
| Ojo et al. | Microanatomical effects of ethanolic extract of Cola nitida on the stomach mucosa of adult Wistar rats | |
| CN107854614A (en) | It is a kind of to be used to treat powder of soft tissue injury and preparation method thereof | |
| KR20190126565A (en) | A composition for improving, preventing and treating of pain containing oriental medicine herbs oil extract as an active ingredient | |
| KR102464877B1 (en) | A composition for improving, preventing and treating bone-related disease comprising Allii Fistulosi Bulbus porridge |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |