KR20140036705A - Composition for improving anorexia containing herb medicines extracts - Google Patents

Abstract

The present invention provides a health supplement composition for treating anorexia, a pharmaceutical composition for preventing or treating anorexia, or a feed additive composition for improving appetite by orally administering each extract of crude drugs such as Sophora tonkinensis Gapnep., Citrus sunki Hort., Cinnamomum zeylanuicum Blume., Gardenia jasminoides var. grandiflora, Salvia miltiorrhiza Bunge, and Zanthoxylum schinifolium S. which improve apetite into animal models having anorexia which are induced by cisplatin in order to check apetite improvement effects without toxicity and side effects when being applied to elders and patients. [Reference numerals] (AA) Cinnamomum zeylanuicum Blume; (BB) Zanthoxylum schinifolium S; (CC) Sophora tonkinensis Gapnep; (DD) Salvia miltiorrhiza Bunge; (EE) Gardenia jasminoides var. grandiflora; (FF) Citrus sunki HORT

Description

Technical Field [0001] The present invention relates to a composition for improving anorexia containing an herbal medicine extract as an active ingredient,

The present invention relates to a pharmaceutical composition for preventing or treating anorexia nervosa and a functional health food composition for improving appetite suppression, which comprises extracting an herbal medicine extract having an excellent appetite stimulating effect using an animal model of acute appetite depressurization induced by cisplatin, Quot;

Anorexia is defined as a lack of or desire for food. Appetite is mainly regulated in the hypothalamus but is regulated by the hypothalamus, physical stimulation of the digestive tract, body fluid components such as blood sugar and free fatty acids, and hormones. Temporal anorexia resumes spontaneously over time, but long-lasting anorexia is accompanied by other symptoms such as coughing and depression.

Typical examples of such anorexia symptoms include the elderly, chronic disease, cancer, and anorexia nervosa.

For the elderly, the cause of anorexia is caused by symptoms such as anorexia and weight loss caused by absorption of nutrients and lowering of metabolism by aging, resulting in dietary or nutritional disorders.

In addition, symptoms of appetite reduction appear in patients receiving cancer chemotherapy, immunodeficiency caused by AIDS disease, immunosuppressed patients by organ transplantation, and other postoperative patients.

In particular, the causes of anorexia nervosa, which causes a primary disorder during anorexia, include psychological factors such as depression, hormone abnormalities such as gastrointestinal digestion and absorption disorders, adrenal insufficiency, and hypophyseal dysfunction, And an anorexia is caused by the involvement of the multiple factors, causing a therapeutic problem.

Anorexia nervosa, such as anorexia, is a psychotic symptom, such as characteristic aspiration of emaciation and abnormal eating behavior, and manifests as somatic symptoms such as weight loss of more than 20% of the standard body weight. It often occurs in young women, and is a serious and sometimes fatal disease.

In the case where the appetite is poor or deteriorated as described above, a yeast containing a large amount of digestive enzymes such as amylase, peptidase and the like is cultured for promoting appetite, and a preparation such as a " do.

On the other hand, the technique for improving anorexia is to increase the nutrient requirement by promoting the secretion of growth hormone, thereby promoting metabolism that increases the conversion of all organs and cells of the body into energy of proteins, carbohydrates and fats, (For example, Korean Patent Publication No. 2002-0002271, U.S. Patent No. 4,411,890).

In addition to these, various vitamins and minerals are formulated into various vitamins and minerals, as well as products directly stimulating the appetite center. Products that directly stimulate the appetite center include "Trastane" and "Episasc capsule" products that prevent binding of serotonin to serotonin receptors in the satiety center. It is a principle that the above-mentioned orotous acid ciproheptadine compound binds to the serotonin receptor instead of serotonin to feel fullness and ignorance of the callus.

In addition, there is only one megestrol acetate currently approved as an appetite stimulant. The above-mentioned megestrol acetate has anti-estrogen properties that interfere with the substitution of the estrogen receptor. It interferes with the normal estrogen cycle and lowers blood LH and exhibits side effects such as petechiae bleeding, menstrual disorders, amenorrhea and edema. Indications of the compounds show an anticancer effect in cancer patients, which promotes appetite during severe weight loss or malnutrition.

As described above, the compound is classified as an anticancer agent and has an antileutening effect on the pituitary gland.

Therefore, although the above-mentioned compound is a specialized medicine approved as an appetite stimulant, the appetite stimulation mechanism of the drug is not known and it is not suitable for use for promoting appetite simply due to weight gain because it is used as a cancer adjuvant.

The compounds known to be useful in the treatment of anorexia as described above are not only very few but also cause many side effects. Therefore, in order to improve anorexia, development of a material having an endocrine system side effect and a more effective effect of improving anorexia without toxicity This is desperately required.

On the other hand, natural products or herbal medicines have a long history of being used as medical materials and have a variety of clinical results. Therefore, its efficacy and safety have been verified, so it is being used as a primary medicine in many countries as a natural product itself.

In other words, the value of natural products or herbals in the development of medicinal materials is due to the safety of medicines that have already been tested for efficacy and have no side effects, and the development period of the medicines is short based on the results accumulated through many clinical results.

Despite the high importance and value of natural materials as medicinal materials, there is no known method for the development of materials aimed at improving anorexia from a herbal medicine having stability at the time of ingestion.

Sophora tonkinensis Gapnep, also known as the Vernam mass, belongs to the leguminosae (Fabaceae) and the medicinal area is the rootstock. The mountain psoas are irregular knotted muscular tofu, and the circumferential root is separated from it. The stem remains at the end of the muscular tofu. The length of root is not constant, but it is 30-50cm, diameter is 7-5cm, outer surface is brown-black brown, there are vertical wrinkles and lateral projecting shrubs. The quality is very hard and difficult to break. The plane is flat but fibrous, the skin is light brown and the neck is pale yellow. There is a smell of soybean, and the taste is very bitter. The efficacy is known to protect the lungs, relieve swelling and swelling, relieve all parasites, relieve throat, cure pain, and relieve fever and poison.

The glue (Cinnamomum zeylanuicum Blume), also called Sri Lankan broiler, belongs to the camphoraceae family (Lauraceae) and the medicinal part is branch. It is a long columnar type with many branches, 30-75cm long and 3-7mm in diameter on the thick side. The outer surface is brown-reddish brown. There are traces of fine wrinkles and leaves, branches or buds attached. The vagina is hard and easy to crumble. The skin of the knuckles is reddish brown and the neck is yellowish white - pale yellowish brown. There is a peculiar smell, a little spicy, and the skin is thicker. The efficacy is known to have the effect of stimulating the communication of stagnant gyeongmaek and improving the stamina (1613).

The dermis (Citrus sunki HORT), also called the product, belongs to the rutaceae and the medicinal part is the periplasm. The dermis is a shell with a constant shape, about 2mm in thickness. Outer surface is yellowish red - dark yellowish brown, and there are many small concave marks due to loss. The inside is white - pale grayish brown. The vagina is light and easy to crumble. There is a peculiar smell, and the taste is slightly irritating in use. Efficacy is effective in diarrhea, and it is known to stop hiccups and coughs (Dongbucho, 1613).

Gardenia (Gardenia jasminoides var grandiflora), also known as gardenia, belongs to the family Rubiaceae, and its medicinal component is fruit. The gardenia is long oval-ovate, 1-5cm long, 10-15mm wide, and usually has 6 distinct ridges extending vertically. There are calyxes or marks on the upper end, and some are attached to the lower end. The outer surface is yellowish brown-blackish brown, and the skin is thin and easy to crumble. The inside of the fruit is divided into two chambers and a lump of seed is attached to the head of yellowish red-dark red. The seeds are almost circular, flat, about 0.5cm in length, and have blackish brown or yellowish red color. It has been known that the efficacy has the therapeutic effect of blood, diuretic effect, and the efficacy of releasing the toxicity (Dongwook-Bo, 1613).

Salvia miltiorrhiza Bunge belongs to Lamiaceae (Lamiaceae) and its medicinal site is root. Danshen is short and rough in its rootstock, and marks on the top of the stems are usually stalks. The roots are long cylindrical, sometimes divided into 1-2 or several, 8-25 cm long, 3-10 mm in diameter. Outer surface is reddish brown - dark reddish brown with rough and vertical wrinkles. The old ones are not very dense, mostly dark brown, usually scaly. The vagina is hard and the folded surface is not dense. There are gaps or generally even, the cortex is reddish brown, the neck is yellow or dark brown and the vascular is yellowish white and radially arranged. The efficacy is known to have the effect of eliminating blood vessels by activating blood circulation.

Sanchos (Zanthoxylum schinifolium S.), also called Sancho wood, belongs to Rutaceae, and its medicinal area is pericarp. Sancho is a capsule made of 2-3 minutes. Each part is circular and divided into 2 pieces. The diameter of each piece is about 5mm. The outer surface of the rind is dark yellow-red-dark red, with many concave tiny dots in the trunk and pale yellowish white on the inside. It is known that efficacy eliminates parasites and is effective for pain (Dongbucho, 1613).

Accordingly, an object of the present invention is to provide a herbal medicine extract having an improved appetite-improving effect, which is stable.

Another object of the present invention is to provide a health functional food composition for improving an appetite suppression which is not burdensome to be applied even to seniors and patients.

It is still another object of the present invention to provide a pharmaceutical composition for preventing and treating anorexia without toxicity and side effects even when applied to the elderly and patients.

The above object of the present invention can be achieved by a method for preparing an herbal composition comprising the steps of: selecting a herbal medicine having an effect of improving an appetite suppression, extracting and extracting each of the herbal extracts using an extraction solvent; Concentrating each filtrate obtained above to obtain a concentrate; Each of the concentrates obtained above was orally administered to an animal model deprived of an appetite induced by Cisplatin, thereby confirming the effect of improving the appetite.

The present invention has an effect of providing an herbal medicine extract having an improved stability of an anorexia.

In addition, there is an excellent effect of providing a health functional food composition for the prevention of anorexia and a pharmaceutical composition for prevention and treatment of anorexia without toxicity and side effects even when applied to the elderly and patients.

FIG. 1 is a graph showing the results of oral administration of cisplatin-induced animal models deprived of an appetite in order to confirm the highest potency of megestrol acetate used as a comparative drug of the present invention.
FIG. 2 is a graph showing the results of confirming an appetite stimulating effect by oral administration of a herbal medicine extract having an effect of improving the anorexia of the present invention to a cisplatin-induced animal model deprived of an appetite.

The extract of the acid pea, dermis, starch, gardenia, ginseng and sancho may be obtained by an extraction process comprising extracting with an extraction solvent selected from the group consisting of water, alcohols or a mixed solvent thereof. More preferably, the extracts of each of the above-mentioned arthropods, dermis, gingiva, gardenia, danshen and sancho can be ethanol extracts obtained by extracting with ethanol. The amount of the extraction solvent used is not limited. For example, the extraction solvent may be used in an amount of about 1 to 10 times by volume, preferably about 5 to 10 times by volume, based on 1 weight of the acidic bipinnite powder sample.

The extraction may be carried out by an extraction method such as cold extraction, hot water extraction, ultrasonic extraction, and reflux cooling extraction for about 1 to 24 hours, preferably about 1 to 5 hours. Preferably, the extraction can be carried out by a reflux cooling extraction method at 79 DEG C, and the extraction process can be performed once or repeatedly, and preferably about 3 times. The obtained extract can be concentrated in a reduced pressure or dried under reduced pressure in a usual manner, for example, at a temperature of about 20 to 100 캜, preferably about 30 to 70 캜, to obtain an extract in liquid or powder form.

The present invention provides a pharmaceutical composition comprising, as an active ingredient, an extract of any one selected from the group consisting of extracts of Acanthopanax senticosus, Dermatophagoides spp., Artemisia sp. The extract is preferably contained in an amount of 0.1 to 99% by weight based on the total weight of the pharmaceutical composition.

The pharmaceutical composition according to the present invention may be formulated into various forms including pharmaceutically acceptable carriers, for example oral preparations, granules, tablets, capsules, suspensions, emulsions, oral preparations such as syrups and aerosols, Can be formulated in the form of sterile injectable solutions. Especially preferably, it may be formulated in an oral dosage form.

The pharmaceutically acceptable carrier may be selected from the group consisting of lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, Cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, and the like. It also includes diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrants, surfactants, and the like. Solid form preparations for oral use include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient such as starch, calcium carbonate, sucrose or lactose ), Gelatin and the like, and may include a lubricant such as magnesium stearate, talc, and the like. Oral liquid preparations include suspensions, solutions, emulsions, syrups, and the like, and may contain diluents such as water and liquid paraffin, wetting agents, sweetening agents, fragrances, preservatives and the like. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, ethylcellulose, polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone, And the like, and the like. Examples of the suppository base include witepsol, macrogol, tween 61, cacao paper, laurin, glycerogelatin and the like.

The present invention provides a pharmaceutical composition comprising, as an active ingredient, an extract of any one selected from the group consisting of extracts of Acanthopanax senticosus, Dermatophagoides spp., Artemisia sp. The extract is preferably contained in an amount of 0.1 to 99% by weight based on the total weight of the health functional food composition.

The food composition of the present invention can be used as a dietary supplement. The term "functional food" as used herein means a food prepared and processed using a raw material or ingredient having a useful function in the human body pursuant to Law No. 6727 on Health Functional Foods, and the term "functional" And function of the nutrient for the purpose of obtaining a beneficial effect in health use such as controlling the nutrient or physiological action.

The food composition of the present invention may contain conventional food additives. Unless otherwise specified, the suitability of the above-mentioned "food additives" is to be determined by the Food and Drug Administration It shall be determined according to standards and standards for the item.

Examples of the substances found in the above-mentioned "food additives" include natural compounds such as ketones, chemical compounds such as glycine, potassium citrate, nicotinic acid and cinnamic acid, coloring pigments, licorice extracts, crystalline cellulose, high- L-glutamic acid sodium preparations, noodle-added alkalis, preservative preparations, tar pigment preparations and the like.

The hard capsule of the capsule type health functional food can be prepared by filling a normal hard capsule with a mixture of herbal medicine extract with an additive such as an excipient or a granular product thereof or a granulated product with a hard gelatinized product. Of the present invention may be filled in a capsule base such as gelatin. The soft capsule may contain a plasticizer such as glycerin or sorbitol, a coloring agent, a preservative and the like, if necessary.

In case of a ring type health functional food, a mixture of excipient, binder, disintegrant, etc. may be formulated into a herbal medicine extract by an appropriate method. If necessary, the preparation may be mixed with white sugar or other suitable skin care agent or a starch, talc or a suitable substance It is possible to make a ring.

In the granular health functional food, a mixture of an excipient, a binder and a disintegrant may be prepared into a granular form by an appropriate method, and if necessary, a flavoring agent, a mating agent and the like may be contained in the herbal medicine extract. The definitions of the above-mentioned excipients, binders, disintegrants, lubricants, mating agents, flavoring agents and the like of the present invention are described in documents known in the art and include the same or similar functions (see, for example, Korean Association of Pharmacy, 5th ed., Pp. 33-48, 1989).

The present invention provides a pharmaceutical composition comprising, as an active ingredient, an extract of any one selected from the group consisting of extracts of Acanthopanax senticosus, Dermatophagoides spp., Artemisia sp. The extract is preferably contained in an amount of 0.1 to 99% by weight based on the total weight of the animal feed additive composition.

Hereinafter, the present invention will be described in more detail through examples and test examples. However, these examples and test examples are for illustrating the present invention, and the scope of the present invention is not limited to these examples and test examples.

< Example  1> invention Mountain bump  Preparation of extract

100 g of acid peel was ground and immersed in 1 L of 95% ethanol, refluxed at 79 캜 for 3 hours and filtered to obtain a filtrate. The obtained filtrate was concentrated under reduced pressure, and then lyophilized to obtain about 14 g of an extract of a dried beet root, which was stored in a freezer.

< Example  2> Production of the dermis extract of the present invention

100 g of dermis was crushed and immersed in 1 L of 95% ethanol, refluxed at 79 ° C for 3 hours and filtered to obtain a filtrate. The obtained filtrate was concentrated under reduced pressure, and then lyophilized to obtain about 33 g of an extract of a dried beet root, which was stored in a freezer.

< Example  3> invention Anchorage  Preparation of extract

100 g of the wax was crushed and immersed in 1 L of 95% ethanol, refluxed at 79 캜 for 3 hours and filtered to obtain a filtrate. The obtained filtrate was concentrated under reduced pressure, and then lyophilized to obtain about 9 g of an extract of a dried beet root, which was stored frozen.

< Example  4> Production of Gardenia Extract According to the Invention

100 g of gardenia were crushed and immersed in 1 L of 95% ethanol, refluxed at 79 ° C for 3 hours and filtered to obtain a filtrate. The obtained filtrate was concentrated under reduced pressure, and then lyophilized to obtain about 19 g of an extract of a dried beet root, which was then frozen and stored.

< Example  5> invention Sansam  Preparation of extract

100 g of Danshen was pulverized and immersed in 1 L of 95% ethanol, refluxed at 79 ° C for 3 hours and filtered to obtain a filtrate. The obtained filtrate was concentrated under reduced pressure and then lyophilized to obtain about 10 g of an extract of ascorbic acid and finally stored in the freezer.

< Example  6> Production of the Acanthopanax senticosus extract

100 g of sancho was pulverized and immersed in 1 L of 95% ethanol, refluxed at 79 캜 for 3 hours and filtered to obtain a filtrate. The obtained filtrate was concentrated under reduced pressure and then lyophilized to obtain about 10 g of an extract of ascorbic acid and finally stored in the freezer.

Six herbal medicine extracts obtained by the method described above were used as disclosure materials for improving anorexia and preventing or treating anorexia.

< Experimental Example  1> Comparative drug megestrol  Maximum drug concentration test

Before confirming the improvement effect of the herbal extract on the anorexia, the highest drug concentration of megestrol, which is the comparative drug, was estimated.

First, male rats of 7 weeks old were purchased, and after a week of purifying period, male rats of 8 weeks old (250 g to 270 g) were prepared. Seven rats were divided into groups for each group, and they were fasted for 24 hours with free water. In the three groups, megestrol acetate was diluted in 0.5% MC twice daily (bid: twice a day) after 18 hours of fasting and 23.5 hours after fasting and suspended in rats at a dose of 25 mg / kg, 35 mg / kg and 45 mg / kg The other three groups were given megestrol acetate at a dose of 50 mg / kg, 70 mg / kg and 90 mg / kg, respectively, after oral administration of megestrol acetate in 0.5% MC once every 23.5 hours Respectively. Twenty-four hours after fasting, cisplatin was injected intraperitoneally into rats by dissolving 2 mg / kg body weight of rats in 5 mL of water for injection.

Immediately after the administration of cisplatin, a rat was placed in a cage and fed with about 50 g of food in a state in which water was freely available. After 24 hours, the amount of food remaining was measured to calculate the food intake of the rats, and the difference in food intake between each group and the cisplatin-only group was compared.

As shown in the following Table 1 and FIG. 1, the experimental results showed that the cisplatin-treated group showed a significant decrease in the food intake compared to the normal group, and the cisplatin-induced megestrol acetate- And it was confirmed that the food intake was increased.

As a result, the dose of megestrol acetate 50 mg / kg (qd) was 43.0%, that of 70 mg / kg (qd) was 53.6%, that of 90 mg / kg (qd) was 31.8% / kg (bid) and 45.4% (45.4%), respectively.

Compared with megestrol acetate, feed intake Group Food intake (g / 24hr)
(Mean SD) Food intake
Increase (%) Normal 25.1 ± 3.09 100% 2 mg / kg cisplatin alone   15.3 ± 2.69 0 % + 50mg / kg (qd) megestrol 19.5 ± 2.92 ^* 43.0% + 70mg / kg (qd) megestrol 20.6 ± 2.91 ^** 53.6% + 90mg / kg (qd) megestrol 18.4 ± 1.46 ^* 31.8% + 25mg / kg (bid) megestrol 18.2 ± 2.10 ^* 29.3% + 35mg / kg (bid) megestrol 19.7 ± 2.40 ^** 44.4% + 45mg / kg (bid) megestrol 19.8 ± 2.49 ^** 45.7%

Therefore, megestrol acetate was orally administered to rats at a dose of 70 mg / kg once a day, which was the most effective, and was used for comparison with herbal extracts.

< Experimental Example  2> Animal experiment for herbal extract of the present invention

The improvement effect of the six herbal medicine extracts of the present invention obtained according to Examples 1 to 6 on the anorexia nervosa of the six herbs including dandelion, dermis, interloper, gardenia, dansamp, and sancho was confirmed by an animal model of acute appetite deprivation induced by cisplatin .

First, male rats of 7 weeks old were purchased and after 8-week-old male rats (250 g to 270 g) after a week of purifying period. In the present invention, six herb extract extract groups were divided into seven groups for each group, and they were fasted for 24 hours in a state in which water was freely taken. The extracts were diluted in 0.5% methylcellulose (MC) twice daily (bid: twice a day) after 18 hours of fasting and 23.5 hours of fasting. The extracts were then diluted to 600 mg / kg of acid isotope, 600 mg / kg of dermis, kg of gentamicin, 600 mg / kg of ginseng and 600 mg / kg of ginseng extract were orally administered to rats, respectively, and megestrol acetate, a comparative drug, was administered once to 0.5% MC (qd: once a day) only after 23.5 hours of fasting 70 mg / kg. After 24 hours of fasting, cisplatin was injected intraperitoneally into rats by dissolving 2 mg of cisplatin per kg of body weight in 5 mL of water for injection.

Immediately after the administration of cisplatin, a rat was placed in a cage and fed with about 50 g of food in a state in which water was freely available. After 24 hours, the remaining amount of food was measured to calculate the food intake of the rats, and the difference in food intake between each group of cisplatin alone and each extract group was compared.

As shown in the following Table 2 and FIG. 2, the experimental results showed that the cisplatin-treated group showed a significant decrease in the food intake as compared with the normal group, and the cisplatin-induced and cisplatin- 61.4% in the control group, 61.0% in the control group, 61.0% in the control group, 52.8% in the extract group, 45.9% in the extract group, 45.8% in the extract group and 38.3% in the dermatophyte extract group .

The intakes of the feed according to the herbal medicine extract administration of the present invention Group Food intake (g / 24hr)
(Mean SD) Food intake
Increase (%) Normal 27.2 ± 3.87 100% 2 mg / kg cisplatin alone   7.92 + - 0.51 0 % + 600mg / kg wax 19.7 ± 2.72 ^** 61.4% + 600mg / kg Sancho 19.7 ± 5.29 ^** 61.0% + 600mg / kg acid bumps 18.1 ± 4.78 ^** 52.8% + 600mg / kg ginseng 16.8 ± 5.95 ^** 45.9% + 600mg / kg of gardenia 16.7 ± 7.79 ^* 45.8% + 600mg / kg dermis 15.3 ± 3.23 ^* 38.3% + 70mg / kg megestrol 17.8 ± 4.57 ^** 51.2%

These results demonstrate that megestrol acetate has the same efficacy as megestrol acetate, which is the only specialty drug currently marketed as an appetite stimulant, and proved that the above extracts are superior to the specialty medicines in promoting appetite.

From the above description, those skilled in the art will understand that the present invention can be implemented in other specific forms without changing the technical spirit or essential features. In this regard, it should be understood that the above-described embodiments are to be considered in all respects as illustrative and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention without departing from the scope of the present invention as defined by the appended claims.

INDUSTRIAL APPLICABILITY As described above, the present invention provides a health functional food composition for improving anorexia without toxicity and side effects even when applied to the elderly and patients, by providing a herbal medicine extract having an improved stability of anorexia It is an extremely useful invention in the health functional food industry, the biopharmaceutical industry, or the animal feed industry because of its excellent effect of providing a pharmaceutical composition.

Claims (8)

A pharmaceutical composition for the prevention and treatment of anorexia, which comprises, as an active ingredient, any one of the extracts selected from the group consisting of acantholipids, dermis, gingiva, ginger, ginseng and sancho. The composition of claim 1, wherein the composition is selected from the group consisting of tablets, pills, powders, granules, capsules, suspensions, solvents, emulsions, syrups, sterile aqueous solutions, non-aqueous solvents, suspensions, lyophilized preparations and suppositories. A pharmaceutical composition, characterized in that it has any one formulation. The pharmaceutical composition of claim 1, wherein the composition further comprises a pharmaceutically acceptable carrier, excipient or diluent. A health functional food composition for improving an appetite suppressing effect, which comprises, as an active ingredient, any of extracts selected from the group consisting of acantholipids, dermis, gingiva, ginger, radish, and sancho. 5. The health functional food composition according to claim 4, wherein the composition has any one form selected from the group consisting of capsules, pills, and granules. 5. The health functional food composition according to claim 4, wherein the composition further comprises a pharmaceutically acceptable carrier, excipient or diluent. The composition according to any one of claims 1 to 4, wherein the extract is obtained by extraction with water or a mixture of water and alcohols. Wherein the active ingredient is selected from the group consisting of herbaceous perennial herbs, dermis, dermis, ginger, gardenia, ginseng, and sancho.

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