KR20140033813A - Skin whitening cosmetics - Google Patents

Abstract

The present invention relates to a skin whitening cosmetic composition which includes gomisin A composition as an active ingredient. The gomisin A: has an outstanding skin whitening effect and a skin wrinkle improving effect; does not have side effects; and highly safe to skin. The content of the gomisin A used for producing an external skin ointment or a cosmetic material, which include gomisin A, is, in dry weight, 0.00001-10.0 wt % of the total content of the composition.

Description

Skin whitening cosmetics

The present invention relates to a cosmetic composition for skin whitening comprising gomisin A as an active ingredient, and more particularly to a composition having a melanin production inhibitory effect can be used safely without side effects on the skin.

Skin is the largest tissue in the human body and plays an important role in protecting the interior of the skin from external stimuli as a primary barrier. These skins appear differently in color with age or with age, depending on the concentration and distribution of melanin inside the skin. Skin melanogenesis is a defense mechanism against stimuli such as ultraviolet light in melanocyte-producing cells (melanocyte), and a large amount of melanin produced by the melanin is transferred to keratinocyte and accumulated on the skin surface layer Results. Although melanin protects the skin, hyperpigmentation of the skin causes skin irritation, freckles, darkening of the skin after inflammation of the skin and aging pigmentation spots. This causes the discomfort of the person not only the cosmetic discomfort but also the psychological negative affect on the social activities. . Melanin is produced by tyrosine tyrosine, an enzyme called tyrosinase, converted into DOPA or dopaquinone, and then enzymatically oxidized to form an abnormal deposit in the skin And it is known that it produces spots and black spots.

Various compositions have conventionally been used to inhibit melanin production of the skin as described above. For example, various extracts extracted from L-ascorbic acid and its derivatives, hydroquinone, arbutin and licorice, and lettuce skin are used as skin whitening agents. However, L-ascorbic acid is easily oxidized to cause irritation to the skin, and the cosmetics containing it cause discoloration and discoloration problems. The substances derived from plant extracts have a great difference in efficacy depending on the plant's origin, thus maintaining homogeneity of the product. It is difficult to do, and arbutin has the disadvantage of low effect.

In order to solve the problems as described above, the present invention provides a cosmetic composition comprising a gomisin A (gomisin A) having no skin side effects and excellent skin whitening effect.

The present invention provides a cosmetic composition comprising a compound represented by the following formula (1) excellent in melanin production inhibitory effect as an active ingredient.

[Formula 1]

The superstition A

Gomisin A and gomisin N are constituents of schizandra chinensis Baillin, a deciduous vine plant of the liana.

The present invention provides a composition for skin revelation containing the compound represented by Formula 1 as an active ingredient.

The cosmetic composition of the present invention has an excellent whitening effect, almost no skin irritation to the human body, so the safety of the product is excellent, it can be usefully used as a cosmetic composition for skin whitening.

Hereinafter, the present invention will be described in more detail.

The present invention provides a cosmetic composition for skin whitening containing gomisin A of Formula 1 (CAS No. 58546-54-6), as an active ingredient.

Komycin A of the present invention is excellent in skin whitening action by exhibiting a melanin production inhibitory effect. Therefore, the Goshincin A is useful as a cosmetic composition for skin whitening. In addition, the cosmetic composition of the present invention is safe on human skin because it does not show a distinctive pattern in the skin accumulation stimulation test.

The content of the high-mycin A contained in the preparation of the external cosmetic ointment or cosmetic including the high-mycin A is 0.00001 to 10.0% by weight, preferably 0.001 to 1.0% by weight, based on the total weight of the composition. If the content of gomycin A was less than 0.00001% by weight in dry weight based on the total amount of the composition, no obvious effect could be expected, and if it exceeded 10.0% by weight, no apparent increase in effect was observed.

The components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to high mycein A as an active ingredient, and include conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and perfumes, And carriers.

The cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations and sprays, and the like, but are not limited thereto. More specifically, it can be manufactured in the form of a flexible lotion, a convergent lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

Experimental Example 1

Inhibitory effect of melanin production at the cellular level

High-cycin A was added to the culture of B-16 mouse melanoma cells and the whitening effect at the cellular level was tested as follows (Lotan R., Lotan D. Cancer Res. 40: 3345-3350 , 1980).

The final concentration of hypermycin A is 1 μg / ml, 5 μg / ml, and 50 μg / m, and is added to the culture medium when culturing B-16 melanoma cells. The cells are cultured for 3 days, and the cells are trypsin. After treatment and removal from the culture vessel and centrifugation, melanin was extracted. Sodium hydroxide solution to the extraction of melanin (1N concentration) 1 ml and the reaction mixture was dissolved melanin boiled for about 10 minutes, the amount of the produced melanin by measuring the absorbance at 400 nanometers (nm) with a spectrophotometer unit cell allowance (10 ⁶ The experiment was carried out by a method showing the absorbance of the cell). The experiment was repeated three times and the average value was used to calculate the relative melanin production relative to the control group as inhibition rate (%), and the results are shown in Table 1 below.

sample Melanin production Inhibition rate (%) Control group (no addition) 0.047 ± 0.002 - Gomycin A (final concentration 1 μg / ml) 0.031 ± 0.001 34 Gomycin A (final concentration 5 ㎍ / ml) 0.017 ± 0.001 64 Gomycin A (final concentration 50 μg / ml) 0.008 ± 0.001 83 Hydroquinone (final concentration 10 ㎍ / ml) Cell death

                                                      Iterations = 3

As shown in Table 1, it can be seen that Gomycin A has comparable melanin production inhibitory ability against cultured melanoma cells in comparison with hydroquinone, which is a known whitening substance. In addition, hydroquinone has a strong melanin production inhibitory ability at low concentrations, but the cytotoxicity is severe and can not be tested at 10 ㎍ / ml or more, but gomycin A is higher than hydroquinone at 50 ㎍ / ml without showing cytotoxicity Since it has an inhibitory effect on production, it has been shown that the present invention can be very usefully used for improving blemishes and freckles and skin whitening.

Preparation Example 1 and Comparative Example 1

Each of the ingredients shown in Table 2 below was mixed as shown in the following Table 2 to prepare an ointment for external use on the skin.

Composition weight% Production Example 1 Comparative Example 1 Gossip A
Diethyl sebacate
Prepayment
Polyoxyethylene oleyl ether phosphate
Sodium benzoate
vaseline 0.01
8
5
6
Suitable amount
Remaining amount * -
8
5
6
Suitable amount
Remaining amount *

*: Amount to be 100% by weight in total

Preparation Example 2 and Comparative Example 2

Nutrient creams were prepared by mixing the respective ingredients shown in Table 3 below in the proportions shown in Table 3 below.

Composition weight% Production Example 2 Comparative Example 2 Gossip A
Stearic acid
Cetanol
Fiji-20 sorbitan monostearate
Sorbitan monostearate
Mineral oil
Trioctanoate
Triethanolamine
Carbomer
glycerin
Propylene glycol
antiseptic
incense
Purified water 0.01
1.0
2.0
1.0
1.0
10.0
5.0
0.5
0.2
5.0
3.0
Suitable amount
Suitable amount
Remaining amount * -
1.0
2.0
1.0
1.0
10.0
5.0
0.5
0.2
5.0
3.0
Suitable amount
Suitable amount
Remaining amount *

*: Amount to be 100% by weight in total

Preparation Example 3 and Comparative Example 3

The respective ingredients shown in the following Table 4 were mixed in the ratios shown in the following Table 4 to prepare a flexible lotion.

Composition weight% Production Example 3 Comparative Example 3 Gossip A
ethanol
Polyoxyethylene hardened castor oil
Paraoxybenzoic Acid Methyl
glycerin
1,3-butylene glycol
incense
Pigment
Purified water 0.01
10.0
1.0
2
5.0
6.0
Suitable amount
Suitable amount
Remaining amount * -
10.0
1.0
2
5.0
6.0
Suitable amount
Suitable amount
Remaining amount *

*: Amount to be 100% by weight in total

Preparation Example 4 and Comparative Example 4

Each component shown in the following Table 5 was mixed as shown in the following Table 5 to prepare Essence.

Composition weight% Production Example 4 Comparative Example 4 Gossip A
Propylene glycol
glycerin
Sodium hyaluronate aqueous solution (1%)
ethanol
Polyoxyethylene hardened castor oil
Paraoxybenzoic Acid Methyl
Carbomer
Triethanolamine
incense
Purified water 0.01
10.0
10.0
5.0
5.0
1.0
0.1
0.3
0.4
Suitable amount
Remaining amount * -
10.0
10.0
15.0
5.0
1.0
0.1
0.3
0.4
Suitable amount
Remaining amount *

*: Amount to be 100% by weight in total

Preparation Example 5 and Comparative Example 5

A pack was prepared by mixing the respective components shown in Table 6 below in the proportions shown in Table 6 below.

Composition weight% Production Example 5 Comparative Example 5 Gossip A
glycerin
Propylene glycol
Polyvinyl alcohol
ethanol
Polyoxyethylene hardened castor oil
Polyoxyethylene Oleethyl
Paraoxybenzoic Acid Methyl
incense
Pigment
Purified water 0.01
5.0
4.0
15.0
8.0
1.0
1.0
0.2
Suitable amount
Suitable amount
Remaining amount * -
5.0
4.0
15.0
8.0
1.0
1.0
0.2
Suitable amount
Suitable amount
Remaining amount *

*: Amount to be 100% by weight in total

Preparation Example 6 and Comparative Example 6

Nutritional lotion was prepared by mixing the respective ingredients shown in the following Table 7 as shown in Table 7 below.

Composition weight% Production Example 6 Comparative Example 6 Gossip A
Polyoxyethylene hardened castor oil
Paraoxybenzoic Acid Methyl
glycerin
1,3-butylene glycol
Carbomer
Triethanolamine
Propylene glycol
ethanol
Carboxyvinyl polymer
Pigment
incense
Purified water 0.01
1.0
Suitable amount
6.0
5.0
0.2
0.3
5.0
2
One
Suitable amount
Suitable amount
Remaining amount * -
1.0
Suitable amount
6.0
5.0
0.2
0.3
5.0
3.2
0.1
Suitable amount
Suitable amount
Remaining amount *

*: Amount to be 100% by weight in total

Experimental Example 2

Whitening effect test in clinical

Twenty healthy men and women were selected to cover aluminum foil with two rows of six holes with a diameter of 7 mm in the lower part of both arms, and 60 mJ with a ORIEL Solar Simulator 1000W at a distance of 10 cm from the arm. The amount of light of / cm 2 was investigated. Twice a day twice a day from 3 days before irradiation to 3 weeks after irradiation, apply a pair of samples containing non-mycin A and the base prepared in Preparation Example 1-6 and Comparative Example 1-6 on the same line in pairs. It was. Here, in the case of the pack preparations of Production Example 5 and Comparative Example 5, after the application, it was peeled off after 15 minutes. The degree of pigmentation of the preparation examples and the comparative examples was visually determined for each of the above. The results are shown in Table 8 below.

Experimental material Distinct effect (n.) Effective (persons) No difference (persons) Production Example 1 7 7 6 Production Example 2 6 7 7 Production Example 3 2 10 8 Production Example 4 2 9 9 Production Example 5 One 9 10 Production Example 6 2 9 9

As shown in Table 8, the whitening ointment and cosmetics prepared according to Preparation 1-6 exhibited a whitening effect on at least 10 or more of 20 subjects, and also showed no side effects in the skin, and thus was safe. It can be seen that the skin whitening agent has an excellent effect on improving blemishes and freckles.

Claims (3)

A composition for skin whitening comprising an active ingredient of Gomisin A of Formula 1 below.
[Chemical Formula 1]

High Super A The method of claim 1,
A composition for whitening skin, comprising 0.00001 to 10.0% by weight of hypermycin A of Formula 1 based on the total amount of the composition. The composition of claim 1 or 2, wherein the composition is formed of any one of a formulation selected from the group consisting of skin, lotion, cream, foundation, essence, gel, pack, product cleansing and ointment.