KR20140019205A - A composition for alleviating skin diseases using castor been - Google Patents

Abstract

A method for manufacturing a composition for relieving skin diseases using a castor bean includes the steps of: obtaining an extract by heating and compressing the castor bean and a sunflower seed; separating the extract by using purified water; separating a castor extract by using organic solvents; filtering the composition and a sunflower seed extract with cellulose cartridges; purifying the castor bean composition after a concentration process; and adding the sunflower seed extract to the extract with 5 to 30% in comparison with the castor bean extract. [Reference numerals] (1) Step for obtaining an extract by heating and compressing the castor bean and a sunflower seed; (2,DD) Step for separating the extract by using purified water; (3) Step for separating a castor extract by using organic solvents; (4) Step for filtering the composition and a sunflower seed extract with cellulose cartridges; (5) Step for purifying the castor bean composition after a concentration process; (6) Step for adding the sunflower seed extract to the extract with 5 to 30% in the castor bean extract; (7) End of a composition for relieving skin diseases; (AA) Extraction flow chart of the castor bean extract; (BB) Extraction flow chart of the sunflower seed extract; (CC) Step for obtaining the extract by heating and compressing the sunflower seed; (EE) Step for filtering the sunflower seed extract with cellulose cartridges

Description

A composition for alleviating skin diseases using castor been}

The present invention relates to a composition for alleviating skin diseases using Castor seed.

The skin is like a membrane that covers the surface of the body and protects the body from various stimuli and pathogens, but when the balance is broken, irritation, pathogens and protective actions become skin diseases (skin diseases).

Common skin diseases commonly seen include eczema (atopic dermatitis, contact dermatitis, skin dermatitis), diaper dermatitis, bacterial infectious diseases (pyoderma, erythrasma), skin diseases caused by insects and animals, herpes simplex, hyperpigmentation and Hypopigmentation, vitiligo, psoriasis (hand and plantar pustules), seborrheic dermatitis and dandruff, sweat bands, warts, athlete's foot, urticaria, dermatophytosis (repair).

Atopic dermatitis is a disease characterized by severe pruritus and chronic skin rash, also called febrile fever. It is the most common form of eczema in infants, and 32.9% of elementary school students and 37.1% of kindergarten suffer from atopic diseases. There are various methods of treatment such as corticosteroid closure therapy, treatment with cordran tape at daily intervals, and use as an emollient including antipruritic agents such as menthol and phenol.

Contact dermatitis can be divided into five categories: allergic contact dermatitis, irritant dermatitis, toxic contact dermatitis, phototoxic dermatitis and photoallergic dermatitis. Symptoms are that the skin loses its elasticity and has a hard feeling, and as the skin dries, it causes secondary discomfort and pruritus caused by inflammation, pain, blisters and ulcers due to skin cracking. There is also a housewives eczema. In severe cases, hydrophobic emollient petrolatum is applied and steroid ointment is applied.

Diaper dermatitis is caused by a multifactorial factor in continuous exposure to a harmful local environment, the most important of which is due to prolonged exposure to moisture. Most diaper rashes are a response to primary stimuli and are characterized by a lustrous erythema, and in more severe cases, erythematous papules, vesicles, erosions, rashes and ulcers. Treatment may be prophylactic, but in mild cases, topical steroid 1% hydro cartisone cream or antibiotic cream or ointment may be used.

Types of burns range from 1st to 3rd degree burns, 1st degree burns have erythematous edema lesions, some epithelium may have fallen, and hyperpigmentation occurs after inflammation. Second-degree burns are blistered and deep burns show coagulated blood vessels, dry skin and mahogany color, and damaged skin appears marble-white. For treatment, apply petrolatum as a laxative, or locally suppress the inflammation with corticosteroids, and treat povidone-iodide ointment with a topical disinfectant if an infection problem occurs.

Skin pruritus is a unique sensation of the skin that causes a desire to scratch, which can lead to Korean-like symptoms, persisting systemic or seizure persistently, and burning, percussion, or stabbing. Types include urinary pruritus, bile-secreted liver disease, and blood disease. Treatments include pruritic reduction with UVB phototherapy or citricin H ₂ blocker and cyproheptadine antihistamine and antiserotonin.

Psoriasis lesions are erythematous, characterized by covered plates that fall easily in various sizes and papules. Acute lesions tend to be small and drip-like, and the most common areas are elbows, knees, scalp, genitals and buttocks. Representative treatments include repeated exposure to ultraviolet light (UVB), high-efficiency steroids such as clobetasol, and coal tar ointment.

Urticaria (urticaria, hives) are caused by lgEs or by non-immune mechanisms. Symptoms include severe pruritus, a typical symptom of urticaria. It is characterized by clear and serpiginous or polycyclic boundaries surrounded by lupus erythematosus. Treatment includes antihistamine treatment with H ₁ antagonist and steroid treatment.

In various skin diseases, such as side effects of corticosteroids, the risk of phenol-containing agents, the use of steroids or antibiotics, etc., there is an urgent need for emollients without side effects and risks.

The material of the skin disease alleviator used in this disease is as follows.

Castor (Ricinus communis. L) is a perennial herb that is a dicotyledonous rat, which is also known as castor. Native to tropical Africa, it is widely grown in temperate regions of the world. It is about 2m high and is a perennial grass that grows hard like a tree at its origin. Seeds are oval, flat, and have dark brown spots that look like a grain of egg. It contains allergens and contains lysine (Ricin) and lysine (Ricinine).

Sunflower is an annual herb of Asteraceae, about 2m high, yellow large headed stalk is end of stem or branch in August ~ September. Ornamental and distributed throughout the world as Central America. Sunflower seeds also contain palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, vitamin E called tocophenol, and vitamin A called lecithin.

The present inventors have studied to develop an effective yet no side effect and safe skin disease mitigator, the plant extract composition comprising the castor seed extract and sunflower seed extract was found to have excellent skin disease mitigation effect has completed the present invention.

KR 1020070081502 (20070817)

The technology using the conventional castor seed extract is domestic patent 1020070081502 (20070817). 'Method for preparing hair nourishing cream composition using very cauliflower extract and hair nourishing cream composition produced by it' is patented by adding alkali to triethanolamine to remove nasty smell of castor seed extract, but triethanolamine is controversial about fortification hazard Many of these and known hazards are problematic for use on skin that causes cancer, allergens (immune toxins), environmental pollutants, and endocrine disorders.

The present invention is a natural well-being plant and collect the seeds of Castor and sunflower widely cultivated and distributed in Korea to process or process the main components according to its use and to manufacture an environmentally friendly skin disease relieving agent that can maximize the effect by these components As for the method

(1) hot water and sunflower seed, respectively, hydrothermally heated and pressed to obtain an extract

(2) separating the extracts using purified water, respectively

(3) separating the castor seed extract from the extract using an organic solvent

(4) filtering the composition and habari seed extract with cellulose catridge, respectively.

(5) azeotropically enriching the castor seed composition and purifying

(6) adding 5-30% of the sunflower seed extract to the extract of Castor seed extract;

It is characterized in that the method for producing a composition for alleviating skin diseases consisting of.

On the other hand, in addition to the extract according to the present invention, by adding a pharmaceutically acceptable carrier or excipient, it is limited to skin external preparations, such as ointments, patches, cosmetics such as emulsions, packs, lotions, soaps, creams, lotions, cleansing, shampoos It can be prepared to have a formulation selected as an external preparation for skin.

The effective coating amount of the active ingredient represented by the composition may vary depending on the extent, site, age, etc. of various skin diseases, but is generally applied to the disease site twice or several times within the range of 1-5mg / cm 2. do.

The inventors use the property of only layering toxic proteins, highly toxic alkaloids, and allergens without using any hazardous substances in the conventional method (domestic patent 1020070081502 (20070817), greatly shortening the process and economically purifying the seeds of high purity. The present invention was completed by knowing that the extract can be extracted and purified.

The present invention purifies ricinoleic acid [C ₁₈ H ₃₄ O ₃ ; CH ₃ (CH ₂ ) ₅ CH (OH) CH ₂ HC = CH (CH ₂ ) ₇ COOH]] contained in the Castor seed extract at high temperature. Extracting undecylenic acid (C ₁₁ H ₂₀ O ₂ ; CH ₃ (CH ₂ ) ₉ COOH) and adding sunflower seed extract containing vitamin A and vitamin E to the composition, the composition is undecylenic acid. Because it acts to kill pathogenic filamentous fungi, it is excellent in alleviating various skin diseases such as atopic dermatitis. It does not cause acne on all skin types, soothing and smoothing the skin and at the same time preventing aging.

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Hereinafter, the present invention will be described in more detail with reference to Examples.

<Example 1> Preparation of Castor Seed Extract and Sunflower Seed Extract

(1) The seed of Azzurrija was sown by the inventors in April in the field by natural farming, and harvested from August to early November. Sunflowers were sown by the inventors in April, harvested in late October, and dried in a warehouse for two months, and then separated and prepared only by seeds.

(2) Castor seed and sunflower seed are heated by hot water and compressed with 60 ~ 90 ℃ of hot water at a weight ratio of purified water and 1: 2, and then compressed to obtain an extract.

(3) The extract was added to the stirrer at a weight ratio of purified water and 1: 2, respectively, and the temperature was gradually raised to 60 to 80 ° C. After stirring for 2 to 4 hours depending on the weight, the mixture is allowed to stand at room temperature for 2 to 4 hours. The separation of the extract and water is performed by the upper layer of the extract and the lower layer of water. This separates only the upper layer (extract).

(4) Mix the Castor seed extract with an organic solvent (ethanol, acetone) in a ratio of 1: 2, completely dissolve the extract in an organic solvent, and again mix the purified water with the composition in a ratio of 1: 1, and then keep the temperature below 60 ° C. Stir slowly while raising. After stirring for 2 to 4 hours depending on the weight, the mixture was allowed to stand at room temperature for 2 to 4 hours to separate the layers and separate only the Castor seed extract and the upper layer, which is an organic solvent portion. However, this process is not necessary for sunflower seed extract.

(5) Filter using a cellulose cartridge.

(6) The azalea seed composition is azeotropically concentrated to completely remove the organic solvent and purify and purify at 400 ° C. or higher under reduced pressure.

The above steps yield the Castor Seed Extract and Sunflower Seed Extract.

<Example 2> Composition ratio calculation according to skin suitability

This experiment was performed with the Castor Seed Extract and Sunflower Seed Extract obtained in Example 1, and had no history of hypersensitivity to skin irritation. The proportion was applied in an amount of 1 mg / cm 2 from 0% to 30%, respectively.

The result of the test shown in [Table 1] shows that the ratio of the sunflower seed extract to the extract of Castor seed is 5 to 5 when comparing the sticky (friction coefficient ↑) and the slippery (friction coefficient ↓) properties of the opposite sunflower seed extract. 10% was found to be most suitable.

<Example 3> Human skin irritation experiment

In this experiment, a human intelligence test was conducted to determine the degree of skin irritation of the composition for alleviating skin diseases according to the change in the content of sunflower seed extract compared to the Castor seed extract. Experimental personnel and subjects were the same person of Example 2 above.

Experimental method was first wiped off the experiment site with 70% ethyl alcohol and dried, and each of the five compositions of Example 2 was buried 1mg each on a paper disk and fixed to the skin of the inner part of the arm with a scan tape. After 24 hours, the splint was removed and the test site was marked with a planetary pan. After 30 minutes and 24 hours, the skin reaction of each test site was visually read.

Criteria were based on the criteria of the International Contact Dermatitis Research Committee (CDRG) (skin response evaluation criteria; 0 points (no response),? + Is 0.5 points (suspect question), + is 1 point (weak (non-vesicular)). Reactions-erythema or papules, + 2 points (strong (edematous or bullous) reactions-erythematous papules or small vesicles), + + + 3 points (extreme reaction-all in front, large vesicles and blisters) Sometimes ulcers)

Average skin reactivity = {(0 points × no response number + 0.5 points × number of reactions + 1 point × number of reactions + 2 points × number of reactions + 3 points × number of reactions) / (maximum score (3) × total Number of Subjects (10))} × 100

As shown in [Table 2], it was confirmed that no matter what percentage of the composition, there was no skin irritation.

<Example 4> Confirmation of various skin disease alleviation effect

The composition prepared according to Example 2 was applied to the 20 subjects, 2 to 78 years old, male and female, each having atopic dermatitis and various skin diseases, in an amount of 1 to 5 mg / cm 2, 2 to 5 times a day. Edo was applied steadily, and in the case of dandruff, it was added to the existing shampoo to wash the hair.

Types of various skin diseases

1. Atopy 2. Photoallergic 3. Otitis 4. Sinusitis 5. Corn 6. Warts 7. Hemorrhoids 8. Burn 9. Sweatband 10. Diaper Rash 11. Dandruff 12. Hand Bending 13. Heel Cracking 14. Bee When 15. Viral lip disease (simple herpes) 16. Lactam 17. Skin anti-inflammatory 18. Athlete's foot 19. Sole swelling psoriasis 20. Housewife eczema 21. Perfection 22. Skin stunting

In the above [Table 3], ○, △ is a case of having a skin disease, ○ is a good effect and cure, △ is a case of less effect. As a result, the composition of the present invention has the advantage of excellent relief of various skin diseases and a high user satisfaction.

Claims (8)

A composition for alleviating skin diseases comprising acacia seed extract The method of claim 1,
Skin disease relief composition, characterized in that for adding the sunflower seed extract to the extract (1) hot water and sunflower seed, respectively, hydrothermally heated and pressed to obtain an extract
(2) separating the extracts using purified water, respectively
(3) separating the castor extract from the extract using an organic solvent
(4) filtering said composition and sunflower seed extract with a cellulose cartridge, respectively.
(5) azeotropically enriching the castor seed composition and purifying and purifying
(6) adding 5-30% of the sunflower seed extract to the extract, compared to the Castor seed extract; Skin disease relief composition, characterized in that consisting of Claim 3
Step (1) is characterized in that the same amount of Castor and sunflower seeds are mixed with water at a weight ratio of 1: 1 to 1: 3, and the extract is obtained after hot heating at a temperature of 60 to 90 ° C. for 24 to 48 hours. Skin disease alleviation composition The method according to claim 3,
Step (2) is characterized by separating the layers by mixing the 'extract' to 'purified water' in a weight ratio of 1: 2, step (3) is mixed with the 'extract' to 'organic solvent' in a weight ratio of 1: 2 and again A composition for alleviating skin diseases, characterized in that the 'purified water' is mixed with the composition in a weight ratio of 1: 1. The method according to claim 3,
Step (4) is characterized by filtration with a cellulose cartridge, step (5) is azeotropic composition composition for alleviating skin diseases, characterized in that the azeotropic seed composition is azeotropically concentrated and purified under reduced pressure at 400 ℃ The method according to claim 1,
A composition characterized in that the composition is a formulation of an ointment or a patch. The method according to claim 1,
Wherein the composition is a formulation selected from solution, suspension, emulsion, paste, emulsion, gel, cream, lotion, soap, cleansing, spray and shampoo, and lotion.

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