KR20140000275A - 인체 면역결핍 바이러스에 대해 항체 모집 및 진입 저해 활성을 갖는 2작용기의 분자 - Google Patents
인체 면역결핍 바이러스에 대해 항체 모집 및 진입 저해 활성을 갖는 2작용기의 분자 Download PDFInfo
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- KR20140000275A KR20140000275A KR1020137015098A KR20137015098A KR20140000275A KR 20140000275 A KR20140000275 A KR 20140000275A KR 1020137015098 A KR1020137015098 A KR 1020137015098A KR 20137015098 A KR20137015098 A KR 20137015098A KR 20140000275 A KR20140000275 A KR 20140000275A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- group
- compound
- hiv
- nhc
- Prior art date
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- Chemical & Material Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
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| US41497710P | 2010-11-18 | 2010-11-18 | |
| US61/414,977 | 2010-11-18 | ||
| US201161522518P | 2011-08-11 | 2011-08-11 | |
| US61/522,518 | 2011-08-11 | ||
| PCT/US2011/061174 WO2012068366A2 (en) | 2010-11-18 | 2011-11-17 | Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus |
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| KR20140000275A true KR20140000275A (ko) | 2014-01-02 |
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| KR1020137015098A KR20140000275A (ko) | 2010-11-18 | 2011-11-17 | 인체 면역결핍 바이러스에 대해 항체 모집 및 진입 저해 활성을 갖는 2작용기의 분자 |
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| JP (2) | JP6155193B2 (de) |
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| CN (2) | CN103402998B (de) |
| AU (1) | AU2011329829B2 (de) |
| BR (1) | BR112013012309A2 (de) |
| CA (1) | CA2818308A1 (de) |
| CL (1) | CL2013001429A1 (de) |
| CO (1) | CO6801635A2 (de) |
| EA (1) | EA201390726A1 (de) |
| IL (1) | IL226397B (de) |
| MX (1) | MX350974B (de) |
| PE (1) | PE20140406A1 (de) |
| SG (2) | SG10201510402WA (de) |
| WO (1) | WO2012068366A2 (de) |
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| EP2206702B1 (de) | 2001-08-08 | 2011-12-28 | Tobira Therapeutics, Inc. | Bizyklishe Verbindung, ihre Herstellung und Verwendung |
| US9181224B2 (en) * | 2009-10-13 | 2015-11-10 | Yale University | Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus |
| MX350974B (es) | 2010-11-18 | 2017-09-27 | Univ Yale | Moleculas bifuncionales con actividad reclutadora de anticuerpos e inhibidora de la entrada frente al virus de inmunodeficiencia humana. |
| WO2013070688A1 (en) | 2011-11-11 | 2013-05-16 | Yale University | Reprogramming urokinase into an antibody-recruiting anticancer agent |
| US9745334B2 (en) | 2012-04-26 | 2017-08-29 | Yale University | Cytotoxic-drug delivering molecules targeting HIV (CDM-Hs), cytotoxic activity against the human immunodeficiency virus and methods of use |
| US9556167B2 (en) | 2012-05-02 | 2017-01-31 | Yale University | TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs) |
| WO2014178878A1 (en) | 2013-05-03 | 2014-11-06 | Yale University | Synthetic antibody mimetic compounds (syams) targeting cancer, especially prostate cancer |
| AU2015371250B2 (en) * | 2014-12-23 | 2021-01-28 | Tobira Therapeutics, Inc. | Process of making cenicriviroc and related analogs |
| WO2017023994A1 (en) | 2015-08-06 | 2017-02-09 | Yale University | Small molecule based antibody-recruiting compounds for cancer treatment |
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