KR20130118881A - Anti-allergen agent - Google Patents

Abstract

( Problem ) As an antiallergic agent which can inactivate allergens, such as a tick and a pollen, the antiallergic agent of tannic acid and a polyphenol type was known conventionally, but it was inferior in heat resistance, and there existed a problem of coloring, discoloration, and elution. It is an object of the present invention to provide an antiallergic agent having excellent heat resistance, no coloration, and excellent water resistance and processability.
( Solution ) By defining the number of acid points having a pKa of 4.8 or less as the acid concentration, and using an inorganic substance having a high acid concentration, a high antiallergic effect is exhibited, and also excellent in heat resistance, water resistance, low colorability, and workability. It was found that this excellent antiallergic agent can be realized.

Description

Anti-allergens {ANTI-ALLERGEN AGENT}

The present invention relates to an anti-allergen comprising an inorganic powder having a specific acid concentration and an anti-allergen composition and product containing the anti-allergen. Anti-allergens can be applied to textile products such as clothing, bedding, masks, filters used in air purifiers and air conditioners, interior products such as curtains, carpets, furniture, etc. By fixing to the surface layer of the material, it is possible to give an effect of reducing allergens caused by ticks, pollen and the like.

Recently, an increasing number of people suffering from allergic diseases such as bronchial asthma, pollen allergy, allergic rhinitis, atopic dermatitis due to pollen allergy due to cedar pollen or house dust caused by mites have become a serious problem. As a treatment for allergic diseases, a series of drugs called anti-allergic agents or inhaled or external steroids have been developed and advanced, but they are not curative treatments because they do not escape the symptomatic area.

In addition, while mites are commonly used to relieve mites in house dust, American house dust mites and European house dust mites in house dust are characterized by allergen reactions not only in the larvae but also in their stool and carcasses. As the body decomposes, allergens of the microparticles are gradually released, so killing ticks does not deactivate allergens. In addition, the mask is used to prevent inhalation of pollen such as cedar, but since the pollen attached to the mask does not lose allergen activity, there is a risk of inhalation by scattering again.

In order to prevent alleviation of symptoms or new sensitization of allergic diseases, it is necessary to remove allergens that cause allergic symptoms from the living space or denature them before being aspirated in the human body.

As a method of removing allergens without using a medicament, there is a method in which allergens are reduced by physically removing floor surface deposition dust and airborne dust by suction or an air cleaner by an electric vacuum cleaner. However, a large amount of allergen sucked by the vacuum cleaner is only stored in the dust collection bag, so that the risk of allergens re-flying upon disposal of the dust collection bag may be considered. In addition, the removal by the air purifier is difficult to completely remove the fine particulate matter, there is a risk of re-scattering.

In recent years, anti-allergic agents have been proposed in which the reaction site of harmful allergens with antibodies is inactivated by the effect of adsorption, coating, or the like, thereby making them harmless. For example, methods using tannic acid are disclosed in Patent Literatures 1 and 2, Non-Patent Literature 1, and the like, and Patent Literature 3 discloses polyphenols such as tea extract and gallic acid, which are analogous compounds of tannic acid. However, organic allergen-reducing agents such as tannic acid are chemically unstable and, if adhered to fibers or textile products, cause coloration or discoloration over time, or flow out to the environment by moisture, oil, solvents, or laundry. The problem is that it can get dirty or irritate the skin. For example, Patent Document 1 discloses that it is possible to remove tannic acid with distilled water. Therefore, it is clear that tannin acid is lost when the fibers treated with tannic acid are repeatedly washed. Therefore, it is problematic to use it as an anti-allergic agent for fibers or textile products which may be washed or directly touched to the skin, and it is limited to those which can be used in textile products exposed to humans even in problems such as color tone, heat resistance and durability. There was a flaw. As an improvement of such a fault, the antiallergic agent which consists of inorganic substances is proposed. Patent Document 4 discloses adsorption of allergens using an inorganic substance such as activated carbon. However, materials such as activated carbon, which have a large porous specific surface area and exhibit adsorption on the principle of physical adsorption, generally have low antiallergen adsorption performance. Moreover, since it is black, there exists a problem that a use is limited. In addition, Patent Document 5 discloses that an inorganic substance having high solid acid strength is excellent in antiallergen activity. However, even if the substance exhibits an equivalent solid acid strength, there may be a significant difference in allergen inactivation performance in practice, and the higher solid acid strength alone does not necessarily indicate superior antiallergen activity. In addition, when using a solid acid having a very high solid acid strength to perform fiber processing or the like in an aqueous system, it has also been apparent that a problem of corrosion of the metal part of the processing apparatus may occur.

Japanese Laid-Open Patent Publication No. 61-44821 Japanese Patent Publication Hei 2-16731 Japanese Patent Laid-Open No. 6-279273 Japanese Unexamined Patent Publication No. 2002-167332 WO2009 / 044648 International Publication Brochure

 A recent study on total tannin Pharmacy Journal No. 103 (2), pages 125-142

In view of the above circumstances, the present invention is an antiallergic agent composed of an inorganic substance having high antiallergic performance, excellent heat resistance and processability, and low colorability and does not leak into water, and preferably, even when used as a coating composition or a resin composition. It is an object of the present invention to provide an antiallergic agent that does not easily cause corrosion or discoloration of a mechanical device, an antiallergen composition using the same, and an antiallergen product.

MEANS TO SOLVE THE PROBLEM As a result of earnestly examining in order to solve the said subject, it discovered that the inorganic powder whose acid concentration is 0.001 mmol / g or more whose pKa is 4.8 or less expresses high antiallergen activity, and completed this invention. The present invention is an antiallergic agent comprising an inorganic powder having an acid concentration of 0.001 mmol / g or more having a pKa of 4.8 or less, an antiallergen composition using the antiallergen and an antiallergen product.

Compared with the existing antiallergic agents, the antiallergic agent of the present invention not only exhibits high antiallergic activity, but also has excellent heat resistance because it is an inorganic substance, and also has low colorability and discoloration and is durable because it does not spill into water. will be. By a simple processing method for various products, excellent antiallergic properties can be imparted.

Hereinafter, the present invention will be described.

The acid concentration used in the anti-allergic agent of the present invention is the amount of acid point or acidic center on the solid surface, and can usually be expressed as the number or moles per unit weight of the solid or per unit surface area. The acid strength of the acid point added to the amount of acid concentration can be expressed by pKa. The acid strength indicates the strength of the acid point imparting protons to the base, or the nature of receiving electron pairs from the base, and the smaller the pKa of the acidic point, the more protons are imparted to the base, or the electron pairs from the base. The intensity | strength of the property to receive becomes strong, and the ability to adsorb | suck and inactivate allergen protein becomes high.

However, since one acid point cannot adsorb another allergen protein while adsorbing one allergen protein, even if the acid strength of each acid point is high, if the quantity of the acid point, that is, the acid concentration is low, it is immediately saturated. Adsorption can not be achieved to show sufficient antiallergen effect. When the allergen protein is present in a large amount, the amount of water to be adsorbed, that is, the acid concentration is high, shows a high antiallergen effect.

On the other hand, when the acid strength of the acidic point is small, that is, the pKa is large, the strength of the property of imparting protons to the base or the property of receiving electron pairs from the base is weakened. Since the ability to adsorb and inactivate allergen proteins decreases, it becomes difficult to sufficiently adsorb allergen proteins, no matter how large the number of acid points, i.e., the acid concentration. This balance is related to the structure and basicity of the allergen protein, and the acidity of the acid point. However, the results of the investigation of the typical allergen protein in the present invention show that allergens when the pKa of the acid point of the inorganic substance having an acid point is 4.8 or less The inactivation effect was shown on the protein, and the number of acid points, that is, the acid concentration and the antiallergen effect, were correlated regardless of the type of allergen protein. That is, it was found that when the acid concentration of a solid acid having a pKa of acidic point of 4.8 or less is measured, it can be used as an index of antiallergen performance of the substance.

More specifically, in the anti-allergic agent of the present invention, the number of scattering points of the powder of the inorganic substance having a pKa of 4.8 or less is defined as the "acid concentration" in the present invention. It is high and is a preferable antiallergic agent. Specifically, the acid concentration is preferably 0.001 mmol / g or more. Although there is no upper limit which should not exceed an acid concentration, since the powder of the inorganic substance exceeding 10 mmol / g is not generally known as a specific material, a normal upper limit is 10 mmol / g or less.

Determination of the number of scattered points having a pKa of 4.8 or less defines the value as a scattered concentration of pKa of 4.8 or less, since the sum of all scattered points having a pKa of 4.8 or less can be measured by applying a titration method using an indicator corresponding to pKa of 4.8. do. More preferable acid point concentration in this invention is 0.01 mmol / g or more, More preferably, acid concentration is 0.05 mmol / g or more. In particular, the antiallergen effect of the inorganic substance having an acid concentration of 0.05 mmol / g or more is excellent, showing a high effect on various allergen substances.

The acid concentration can be determined by measuring the amount of base that reacts with the powder. There is a method of measuring in the liquid phase or gaseous phase, the measurement in the liquid phase is a titration method, the measurement in the gas phase is a gas chemisorption method, a method of measuring the difference between the adsorption-desorption amount of He and hydrogen gas and the adsorption-desorption amount of basic gas is known. However, since the reaction of the anti-allergen agent and allergen in this invention is reaction through a liquid, the measurement by the titration method in a liquid phase is suitable.

The measuring method of the acid point concentration of the inorganic powder by the titration method in a liquid phase is as follows.

The inorganic powder dispersed in the nonpolar solvent is titrated with n-butylamine, and the end point of the titration is confirmed by discoloration of the indicator. The indicator before the reaction shows a basic color, but when adsorbed on an inorganic powder, the indicator shows a color of the conjugate acid type. The acid point concentration is determined from the appropriate amount of n-butylamine required from the color of the conjugate acid type to the color of the base type. One acidic point of a solid and one molecule of n-butylamine correspond. Since the base for titration has to replace the indicator bound to the solid acid point, its basicity should be stronger than that of the indicator. As a conventional titration method, when an indicator is first added to the inorganic powder / benzene dispersion, the indicator becomes acidic by solid acidity, but it is preferable to allow sufficient time until the reaction is completed. Next, n-butylamine is dripped, and acid concentration is computed from the quantity of n-butylamine when the color of an indicator returns to the original index basic color.

More specifically, 0.5 g of inorganic powder is placed in a 20 ml sample bottle, and 10 ml of benzene is added thereto and shaken gently. Furthermore, 0.1 N of n-butylamine which stirred the addition amount in 20 steps is added, and it stirred with a shaker. After 24 hours, 0.5 ml of 0.1% indicator methyl red solution is added, and discoloration of the indicator is observed. The addition amount of the n-butylamine of the system with the most addition amount of the n-butylamine which the discoloration of the indicator was not confirmed is made into the base amount which reacted with an acidic point, and is represented as acidic acid concentration (mmol / g). N is also referred to as a degree of regulation, and is a conventional unit of a person skilled in the art, defined by the number of acids of an acid value of the degree of regulation = molar concentration x 1 molecule.

Inorganic materials with high acid concentrations are individuals with many acid sites on their surfaces. Specific examples of the inorganic substance having a high acid concentration include, but are not limited to, amorphous magnesium silicate, α-type zirconium phosphate, layered titanium phosphate, activated alumina, activated titania, and the like.

In order to apply the anti-allergen agent in this invention to the process with respect to a various material and a form, preferable average particle diameter is 0.01-50 micrometers, More preferably, it is 0.02 micrometer-20 micrometers. The powder having an average particle diameter of 0.01 µm or more has the advantage of being easy to handle because it is difficult to reaggregate. In addition, in the case of dispersing in a binder or the like and post-processing the fibers, the particles having an average particle diameter of 50 µm or less have good dispersibility and do not inhibit the texture of the fibers, or do not easily break the yarn when kneaded into the fibers. It is preferable because there are advantages such as. The representative value of an average particle diameter can be measured with a laser diffraction type particle size distribution meter, etc. The median diameter analyzed on the volume basis can be used as a representative value of a particle size.

Although there is no limitation in the color tone of the antiallergic agent in this invention, In order to apply to processing to various materials and a form, white or high light color is preferable. Preferable brightness | luminance is 60 or more by L value when it measures with a chromatic color difference meter.

Moreover, it is preferable that the acid substance pKa is 1.5 or less in the inorganic substance which comprises the antiallergic agent in this invention. This is because, in addition to having a high acid concentration, high acid strength as a solid acid has higher antiallergic properties. The acid strength of the anti-allergic agent in the present invention is the ability of an acid point on the surface of the anti-allergic agent to impart a proton to a base or to accept an electron pair from the base. The measurement of acid strength can be carried out by using an indicator. When an appropriate indicator is selected as the base, the acid strength can be measured by the ability to change the base form of the indicator into the conjugated acid form.

Examples of indicators and (pKa values) that can be used for measuring the acid strength include methyl red (+4.8), 4-phenylazo-1-naphthylamine (+4.0), dimethyl yellow (+3.3), 2-amino-5-azotoluene (+2.0), 4-phenylazo-diphenylamine (+1.5), 4-dimethylaminoazo-1-naphthalene (+1.2), crystal violet (+0.8) , p-nitrobenzeneazo-p'-nitro-diphenylamine (+0.43), dicinnamil acetone (-3.0), benzalacetophenone (-5.6), anthraquinone (-8.2), and the like. The acid strength can be measured by using various acid base conversion indicators of which these acid strengths (pKa) are known. The more the PKa discolors the indicator, the greater the acid strength.

The measuring method of acid strength of the inorganic solid acid using the said indicator is as follows.

0.1 g of solid acid is collected in a test tube, and 2 ml of benzene is added and shaken gently. Two drops of 0.1% benzene solution (however, crystal violet is not 0.1% ethanol solution, but 0.1% ethanol solution) as an indicator is added thereto, and the mixture is shaken gently to observe color change. The acid strength of the solid acid is less than the strongest acid strength (ie, the lowest pKa value) at which discoloration of the indicator is observed, and the discoloration of the indicator is greater than the weakest acid strength (ie, the highest pKa value) at which no indicator is identified. This pKa value of the said inorganic solid acid is described as (the highest pKa value in which discoloration was not confirmed)-(lowest pKa value in which discoloration was confirmed). Furthermore, it is less than (the lowest pKa value at which discoloration is confirmed) in the absence of a suitable indicator indicating the lower limit, and greater than (the highest pKa value at which discoloration is not identified) in the absence of a suitable indicator indicating the upper limit. It is common to denote as.

The inorganic substance in this invention has a constant moisture content, and anti-allergen effect becomes easy to be expressed. As for the preferable water content in an inorganic substance, 0.5 wt% or more is preferable, More preferably, it is 2 wt% or more, More preferably, it is 10 wt% or more. In addition, the inorganic material having hygroscopicity is excellent in that moisture can be retained in the inorganic material even when mixed with other materials or the humidity of the air changes, and the inorganic material itself has the water necessary for allergen deactivation.

The anti-allergen effect in this invention can be evaluated by the sandwich method of the ELISA method widely used as an antigen detection and quantification method, and can express it as an allergen inactivation rate (unit%) shown in <Formula 1>. An initial allergen amount shows the amount of allergen evaluated without using the sample used for ELISA evaluation, and a residual allergen amount shows the amount of allergen after contact with a sample. In addition, allergen inactivation in this invention suppresses reaction of an allergen with the specific antibody, and it is so preferable that an allergen inactivation rate is high. Specifically, the allergen inactivation rate is preferably 90% or more, more preferably the allergen inactivation rate is 99% or more.

Allergen inactivation rate

= (1-residual allergen amount / initial allergen amount) × 100 (%) <Equation 1>

There is no restriction | limiting in particular in the use form of the antiallergic agent of this invention, According to a use, it can be mixed with another component suitably, or it can be compounded with another material. For example, it can be used in various forms, such as powder, powder containing dispersion liquid, powder containing particle | grains, powder containing paint, powder containing fiber, powder containing paper, powder containing plastic, powder containing film, and powder containing aerosol, Therefore, it can also be used together with various additives or materials, such as a deodorant, an antibacterial agent, an antifungal agent, a flame retardant, an anticorrosive, a fertilizer, and a building material. In addition, inactivation of allergens in living spaces by addition to materials that may be in contact with humans, such as resins, paper, plastics, rubber, glass, metals, concrete, wood, paints, fibers, leather, stones, etc. It is possible.

It is preferable to use the antiallergic agent of this invention as a coating composition containing a fixing agent (binder) among these usage methods. An additive other than a binder may be added to this coating composition, and it may also be diluted with a solvent and water before processing a coating composition into the product of various shapes. In the coating composition of the present invention, the larger the weight ratio of the anti-allergic agent / binder solid content is, the easier it is to express the effect. On the other hand, the larger the weight ratio of the binder solid content, the more firmly the anti-allergen agent is fixed and the powder is not easily dropped. Therefore, 90 / 10-30 / 70 are preferable and, as for the weight ratio of antiallergen / binder solid content in the coating composition containing an antiallergic agent, 80 / 20-50 / 50 are more preferable.

When the coating composition is diluted and used, the concentration of the anti-allergic agent contained in the composition is preferably 0.5 to 50% by mass, more preferably 1 to 30% by mass, from the viewpoint of ease of dispersion and good shelf life. In general, since the anti-allergen effect is expressed by the contact of the anti-allergen agent and the allergen on the surface of the product of various shapes, fixing the anti-allergen agent to the surface of the product by the coating composition is used for the entire interior of the product. It is preferable, because a greater effect can be obtained with a smaller amount of anti-allergen.

The binder used for the coating composition of this invention has the following. That is, natural resin, natural resin derivative, phenol resin, xylene resin, urea resin, melamine resin, ketone resin, coumarone-indene resin, petroleum resin, terpene resin, cyclized rubber, chloride rubber, alkyd resin, polyamide resin And polyvinyl chloride, acrylic resin, vinyl chloride and vinyl acetate copolymer resin, polyvinyl acetate, polyvinyl alcohol, polyvinyl futyral, chlorinated polypropylene, styrene resin, epoxy resin, urethane and cellulose derivative. Among them, preferred are acrylic resins, polyvinyl chloride, and vinyl chloride-vinyl acetate copolymer resins. Among them, emulsion resins are preferable because they are low pollution and easy to handle.

The additives that can be used include pigments such as zinc oxide and titanium oxide, dyes, antioxidants, light stabilizers, flame retardants, antistatic agents, foaming agents, impact reinforcing agents, glass fibers, lubricants such as metal soaps, desiccants and extenders, and coupling agents. Examples thereof include a nucleating agent, a fluidity improving agent, a deodorant, a wood powder, an antifoaming agent, an antifouling agent, a rust preventive agent, a metal powder, an ultraviolet absorber, and an ultraviolet ray shielding agent.

As a method of processing a fiber with the coating composition containing the anti-allergic agent of the present invention, there is a method of applying, immersing or spraying a liquid as it is or diluted with a coating composition. There is no restriction | limiting in the fiber which can be processed, For example, natural fiber, such as cotton, silk, and wool, synthetic fiber, such as polyester, nylon, and acrylonitrile, semisynthetic fiber, such as triacetate and diacetate, and regeneration of viscose rayon, etc. A fiber etc. can be mentioned, The composite fiber which used two or more types of these fibers may be sufficient. Moreover, it can be used also for nonwoven fabric which uses polyethylene, a polypropylene, etc. Although the processing method with respect to the antiallergic fiber or textile product of this invention is not specifically limited, There exists an immersion process, a print process, a spraying process, etc., and processing is completed by drying the fiber containing a composition. The drying method may be any one of natural drying, hot air drying, vacuum drying, and the like. Preferably, the drying method is performed by heat, between 40 ° C and 250 ° C, preferably between 50 ° C and 180 ° C for 1 minute to 5 hours, preferably The antiallergen can be fixed to the fiber by drying for 5 minutes to 3 hours.

The amount of adhered amount of the anti-allergic agent of the present invention on the fiber or the fiber product can express an effect at 0.1 g or more with respect to 1 m 2 of the fiber or the fiber product. On the other hand, in order not to inhibit the physical property, a texture, etc. of a fiber or a textile product, 20 g / m <2> or less is preferable, More preferably, it is 1 g-10 g / m <2>.

If the pH of the coating composition containing the anti-allergic agent of the present invention is too low, the metal of the production machine may be corroded, or the treatment liquid may be degraded or the stability may be deteriorated. Since the antiallergen effect may be reduced, when the coating composition is capable of pH measurement such as aqueous system, the pH is preferably 3 or more and 9 or less. Factors for determining the pH of the coating composition are the same as the pH of the aqueous dispersion of the inorganic powder and have a large influence on the pKa of the solid acid, but in addition, the solubility and hydrophilicity of the acid concentration and the antiallergic agent itself, Components other than the allergen also affect, which is difficult to predict, but when the pH is too low, it means that the dispersion itself containing the coating composition becomes acidic, which causes rust when adhered to metal parts such as processing equipment. The effect of is reduced, leading to the dispersion causing precipitation.

In addition, when the coating composition containing the anti-allergic agent of the present invention is non-aqueous, or when used as a paint containing various paint components, even when used as a resin composition containing the anti-allergen agent, the metal parts to be contacted in the same manner. Although it may corrode or discolor the resin, it was found by water dispersion test that the pH is in a certain range because it does not cause rust or discoloration well. In such a water dispersion test, it is a simple method to disperse an anti-allergic agent and to measure its pH. For example, what is necessary is to disperse | distribute to deionized water so that an antiallergic agent may be 5 wt%, and to measure the pH after stirring for 5 minutes with a stirrer at 25 degreeC using a glass electrode type pH meter, and the pH at that time will be 3 It is preferable that it is more than 9 or less. Coating compositions, coatings, resins, and the like using such anti-allergens are preferred because they hardly cause metal corrosion or discoloration. Further, since the coating is a composition for coating purposes, it is one of the coating compositions, but not only for the purpose of fixing the functional components such as anti-allergen agents, but also the cured coating film of the composition maintains a certain strength or more, The coating composition which exhibits weather resistance or the protection and aesthetics of the article surface is particularly called a paint.

The antiallergic agent of the present invention can also be used in combination with a paint. You may add various additives to paint. As the resin component of the paint, oils such as soybean oil, linseed oil, sapling oil, castor oil, natural resins such as rosin, kovar, shellac, processed resins such as chromman resin, petroleum resin, alkyd resin, acrylic resin, epoxy Synthetic resins such as resins, polyurethane resins, vinyl chloride resins, silicone resins and fluorine resins, rubber derivatives such as chlorinated rubbers and cyclized rubbers, cellulose derivatives such as vaginal phase (lacquers) and acetyl cellulose. In addition, the pigments of the paint include (white) titanium, (black) carbon, (brown) bengala, (scarlet) chromium vermilion, (blue) blue blue, (yellow) sulfur lead, (red) iron oxide, calcium carbonate, Extender pigments such as talc and barita powder, rust preventive pigments such as podium, lead nitrite and camide lead, and functional pigments such as aluminum powder and zinc sulfide (fluorescent pigment). In addition, as an additive of the paint, a UV curing agent, a plasticizer, a dispersing agent, an antisettling agent, an emulsifier, a thickener, an antifoaming agent, an antifungal agent, a preservative, an anti-filming agent, a drying agent, a flow inhibitor, a gloss remover, an antistatic agent, a conductive agent, a flame retardant, a graffiti inhibitor, etc. to be. Moreover, as a solvent of paint, thinner, such as water, alcohol, a paint thinner, lacquer thinner, a polyurethane resin thinner, etc. can be prepared by a combination of these.

As a method of processing a base material with the coating material containing the anti-allergic agent of this invention, the brush method, the roller method, the spray (spray) method, the iron coating method, etc. are mentioned to the base material which prepared the paint as it was or the diluted liquid previously. Can be. Moreover, you may harden the apply | coated paint material by UV irradiation. Although there are various kinds of base materials which can be processed, for example, various plastics such as polyethylene, polyvinyl chloride, polyvinylidene chloride, polyvinyl alcohol, polypropylene, polyester, polycarbonate, polystyrene, polyacrylonitrile, cellophane, , Salt sheet, modified silicone or urethane joints, metals, ceramic siding, porcelain, stoneware, pottery, sheet oil tiles, marble, granite, glass and the like.

When the antiallergen / paint solid content weight ratio in the coating material containing the antiallergic agent of this invention is 10/90 or more, a clear effect will be easy to be expressed. Moreover, 50/50 or less is preferable at the point which does not impair economical property, the physical property, a texture, etc. of the base material to apply | coat, or does not significantly impair the physical property, a function, etc. of a coating material. Therefore, 10 / 90-50 / 50 are preferable and, as for the anti allergen agent / paint solid content weight ratio in the coating material containing the antiallergic agent of this invention, 20 / 80-40 / 60 are more preferable.

By blending the anti-allergen agent of the present invention with a resin, the anti-allergen resin composition can be easily obtained. There is no restriction | limiting in the kind of resin which can be used, Any of a natural resin, a synthetic resin, and semisynthetic resin may be sufficient, and any of a thermoplastic resin and a thermosetting resin may be sufficient. As specific resin, any of resin for shaping | molding, resin for fiber, rubber-like resin may be sufficient, for example, polyethylene, a polypropylene, vinyl chloride, ABS resin, AS resin, MBS resin, nylon resin, polyester, polychloride Vinylidene, polystyrene, polyacetal, polycarbonate, PBT, acrylic resin, fluorine resin, polyurethane elastomer, polyester elastomer, melamine, urea resin, tetrafluoroethylene resin, unsaturated polyester resin, rayon, acetate, acrylic, polyvinyl Molding or textile resins such as alcohol, cupra, triacetate, vinylidene, natural rubber, silicone rubber, styrenebutadiene rubber, ethylene propylene rubber, fluorine rubber, nitrile rubber, chlorsulfonated polyethylene rubber, butadiene rubber, synthetic natural Rubbery resins such as rubber, butyl rubber, urethane rubber, and acrylic rubber. In addition to the resin component, various additives may be contained. The additives that can be used include pigments such as zinc oxide and titanium oxide, dyes, antioxidants, light stabilizers, flame retardants, antistatic agents, foaming agents, impact reinforcing agents, glass fibers, lubricants such as metal soaps, desiccants and extenders, coupling agents and nucleating agents. , Fluidity improving agent, cancelling agent, wood powder, antiseptic agent, antifouling agent, rust preventive agent, metal powder, ultraviolet absorber, ultraviolet ray shielding agent and the like, and all can be preferably used.

As the method for producing the resin composition by blending the anti-allergen agent of the present invention with a resin, any known method can be adopted. For example, (1) using a dispersing agent for improving the dispersibility of the anti-allergic agent powder and the resin to improve the dispersibility of the anti-allergic agent powder and resin, and directly mixing the pellet resin or powder resin with a mixer Method, (2) mixing as described above, molding in pellet form by an extrusion molding machine, and then blending the molded product into pellet-like resin, (3) molding an antiallergic agent into a pellet of high concentration using wax. Thereafter, the pellet-shaped molded product is blended into pellet resin, and (4) a method of blending the paste into pellet resin after preparing a paste composition obtained by dispersing and mixing an anti-allergen into a high-viscosity liquid such as polyol. Etc.

All the known molding processing techniques and apparatuses can be used for molding the resin composition according to the properties of various resins, and are easy to mix, mix or knead while heating, pressing or depressurizing at a suitable temperature or pressure. It can be prepared, and their specific operation may be performed by a conventional method, and it can shape | mold in various forms, such as a block shape, a sponge form, a film form, a sheet form, a finishing or a pipe form, or a composite thereof. When the anti-allergen / resin solid content weight ratio in the resin composition containing the anti-allergen of this invention is 10/90 or more, a clear effect is easy to be expressed. Moreover, 50/50 or less is preferable at the point which does not impair economic reason, the moldability of a resin composition, the physical property, a texture, etc. of a molded object. Therefore, the solid content weight ratio of the antiallergen / resin composition in the resin composition containing the antiallergen of the present invention is preferably 10/90 to 50/50, more preferably 20/80 to 40/60.

The use form of the anti-allergic agent of this invention can be used as it is, or suitably mixed with another component or compounded with another material according to the use which requires reduction of allergen other than the composition, resin composition, and resin molded article mentioned above. For example, it can use in all forms, such as powder form, powder dispersion liquid form, granular form, aerosol form, or liquid form.

Anti-allergic agents of the present invention can be used in various fields that require allergen reduction, i.e. indoor articles, beddings, filters, furniture, in-vehicle products, textile products, building products, paper products, toys, leather products, bathroom products, cosmetics and It can be used as other products. For example, carpets, curtains, wallpaper, tatami mats, window coverings, floor waxes, calendars, indoor items, beddings, duvets, beds, sheets, pillows, pillow covers, air cleaners, filters such as air conditioners, sofas, chairs, etc. Furniture, child seats, car seats, such as car seats, dust collector bags of electric vacuum cleaners, medical products, masks, stuffed toys, kitchen supplies, etc., but are not limited to these.

Example

Although an Example demonstrates this invention further in detail below, it does not intend limiting this invention to such an Example.

The average particle diameter of the inorganic powders described in the examples refers to the median diameter based on volume obtained by ultrasonic dispersion in deionized water by a laser diffraction particle size distribution analyzer, and% indicates mass% unless otherwise specified. And unit% of an allergen inactivation rate is based on said <formula 1>.

In the measurement of the acid concentration, 0.5 g of inorganic powder is placed in a 20 ml sample bottle, and 10 ml of benzene is added thereto, and the mixture is shaken lightly. Furthermore, 0.1 N of n-butylamine which stirred the addition amount in 20 steps is added, and it stirred with a shaker. After 24 hours, 0.5 ml of a 0.1% methyl red solution diluted with benzene is added, and discoloration of methyl red is visually observed. The addition amount of n-butylamine with the most addition amount of n-butylamine which the discoloration of methyl red was not confirmed was made into the base amount which reacted with an acidic point, and was called acid point concentration (mmol / g).

To measure the acid strength, 0.1 g of a sample was collected in a test tube, 2 ml of benzene and 0.1% benzene solution (in the case of crystal violet, 0.1% ethanol solution) were added, and the mixture was shaken gently to observe a change in color. It was. The acid strength was recorded as the pKa value since the indicator discoloration is considered to be less than or equal to the strongest acid strength (lowest pKa value) found and the indicator is greater than the weakest acid strength (highest pKa) without discoloration. In addition, the indicators used were methyl red (pKa = 4.8), 4-phenylazo-1-naphthylamine (pKa = 4), dimethyl yellow (pKa = 3.3), 4-phenylazo-diphenylamine (pKa = 1.5) Crystal violet (pKa = 0.8), dicinnamil acetone (pKa = -3), benzalacetophenone (pKa = -5.6), anthraquinone (pKa = -8.2).

The moisture content of the inorganic powder was weighed about 5 g of the sample in an aluminum cup weighed at 250 ° C. for 1 hour in a dryer (to 0.1 mg units), dried at 250 ° C. for 2 hours in a dryer, and then weighed again (to 0.1 mg unit). Weighing) and the drying powder, which were subtracted from the mass before drying, were used as the% display to set the moisture content of the inorganic powder.

The antiallergen effect was evaluated by the ELISA sandwich method using American dust mite allergens (allergens commonly referred to as Derf2) and cedar pollen allergens (allergens commonly referred to as Cryj1). The test operation using the American dust mite allergen is as follows. Antibody coat wells were prepared by a conventional method using an American dust mite allergen (Derf2) specific antibody (15E11 antibody, manufactured by Asahi Beer Co., Ltd.).

3 mg of the sample was weighed and 500 microliters of American dust mite allergens (Derf2) prepared at 40 ng / ml by antigen dilution were added. The mixture was stirred well, the sample was brought into contact with the allergen, and then centrifuged to recover the supernatant, added to a 15E11 antibody coat well treated with a blocking agent, and stopped at room temperature. After 1 hour, the samples were discarded, and each well was washed with a washing buffer, and a mustard radish oxidase-labeled anti-Derf2 monoclonal antibody 13A4PO (Asahi Beer Co., Ltd.) diluted in 200 ng / ml with the washing buffer was added to each well. I stopped at. After 1 hour, the antibody solution was discarded, each well was washed with a washing buffer, and the substrate solution was added to each well to stop at room temperature. After 5 minutes, 2 N sulfuric acid was added to stop the reaction, and the absorbance at 490 nm was measured. The results were obtained by evaluating without using a sample to determine the relationship between the amount of allergen to absorbance, the amount of remaining allergen from the absorbance when the various samples were evaluated, and calculating from the above <Equation 1> to determine the allergen inactivation of the various samples. The percent burn rate is indicated.

The test operation by the sandwich method of ELISA method in case of using cedar pollen allergen is as follows. The antibody coat well was produced by the conventional method using the cedar pollen allergen (Cryj1) specific antibody (Anti-Cryj1 mAb013 by Seika Chemical Co., Ltd.).

3 mg of the sample was weighed and 500 microliters of cedar pollen allergens (Cryj1) prepared at 10 ng / ml by antigen dilution were added. The mixture was stirred well, the sample was brought into contact with the allergen, and then centrifuged to recover the supernatant, added to the Anti-Cryj1mAb013 antibody coat well treated with a blocking agent, and stopped at room temperature. After 1 hour, the samples were discarded, each well was washed with a washing buffer, and mustard oxidase-labeled anti-Cryj1 monoclonal antibody 053 (manufactured by Seikagaku Industry Co., Ltd.) diluted in 250 ng / ml with the washing buffer was added to each well. Was stopped at room temperature. After 2 hours, the antibody solution was discarded, and each well was washed with a washing buffer, and the substrate solution was added to each well to stop at room temperature. After 5 minutes, 2 N sulfuric acid was added to stop the reaction, and the absorbance at 490 nm was measured. The result showed the allergen inactivation rate% of various samples by calculating from Formula 1 by the method similar to American dust mite allergen.

The pH of the aqueous dispersion of the inorganic powder was dispersed in ion-exchanged water of the beaker so that the inorganic powder became 5 wt%, and the pH after stirring for 5 minutes with a stirrer at 25 ° C. was measured using a glass electrode pH meter.

In the resin molding discoloration confirmation test, 2 wt% of the inorganic powder was mixed with the polypropylene powder, and the plate was molded at an injection molding machine at 220 ° C. The degree of coloring of the obtained plate was visually confirmed.

In the metal corrosion test, first, an iron test piece (width / length / thickness = 20/80/2 mm) was prepared, and the surface was washed with acetone. The iron test piece and the inorganic powder 5 wt% aqueous dispersion were put into the glass test tube of diameter 30mm, and it mounted on the heat block adjusted to 60 degreeC. After 24 hours, the test piece was taken out, immersed in distilled water, and ultrasonically cleaned for 5 minutes, dried for 30 minutes with a 50 ° C dryer, and then visually confirmed the presence or absence of rust of the test piece.

The anti-allergen effect of textile products is that allergens use cedar pollen allergen (Cryj1), put 25 cm 2 of fibers in a plastic bag with a chuck, and adjust the sample and 1 ml of allergen solution to 100 ng / ml. After contacting for a time, the contact solution was centrifuged to recover the supernatant, the absorbance was measured by the same ELISA method evaluation as that of the inorganic powder, and the antiallergen inactivation according to the above formula 1 was compared with the absorbance when no sample was used. The percent burn rate was evaluated.

The anti-allergen effect of the resin kneading film is that allergens use cedar pollen allergen (Cryj1), put 25 cm 2 of film into a plastic bag with a chuck, and adjust the sample and 1 ml of allergen solution to 1 ng / ml. After contacting for a time, the contact solution was centrifuged to recover the supernatant, the absorbance was measured by the same ELISA method evaluation as that of the inorganic powder, and the antiallergen inactivation according to the above formula 1 was compared with the absorbance when no sample was used. The percent burn rate was evaluated.

The anti-allergen effect of the film processed by the acrylic UV-curing paint was adjusted to 10 ng / ml by using a cedar potted allergen (Cryj1) as an allergen, and putting 25 cm 2 of film into a plastic bag with a chuck attached thereto. After contacting 1 ml of the allergen solution for 3 hours, the contact solution was centrifuged to recover the supernatant, and the absorbance was measured by the same ELISA method evaluation as that of the inorganic powder, and compared with the absorbance when no sample was used. The antiallergen inactivation rate% was evaluated by 1.

Example 1 Amorphous Magnesium Silicate

An amorphous magnesium silicate (SiO ₂ /MgO=1.3) was obtained by filtration, washing with water, drying and pulverizing the precipitate obtained using magnesium sulfate and water glass as raw materials. Table 1 shows the results of measuring the tick allergen inactivation effect and cedar pollen allergen inactivation effect by the average particle diameter, water content, acid strength, and ELISA method of the obtained amorphous magnesium silicate. In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Example 2 α Type Zirconium Phosphate

An alpha-type zirconium phosphate powder was obtained by adding 15-% zirconium oxychloride aqueous solution to 75-% phosphoric acid aqueous solution, and aged at 120 degreeC for 12 hours, and filtering a precipitate, washing with water, drying, and pulverizing. Table 1 shows the results of measuring the tick allergen inactivation effect and cedar pollen allergen inactivation effect by the average particle diameter, water content, acid strength, and ELISA method of the obtained α-type zirconium phosphate. In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Example 3 Activated Titanium Oxide

The precipitate obtained by using titaniumyl sulfate and oxalic acid as a raw material was filtered and dried, and calcined at 500 ° C, followed by grinding to adjust the activated titanium oxide. Table 1 shows the results obtained by measuring the tick allergen inactivation effect and the cedar pollen allergen inactivation effect by the average particle diameter, water content, acid strength, and ELISA method of the obtained titanium oxide. In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Example 4 Active Clay

Table 1 shows the results obtained by measuring the average particle diameter, acid strength, and tick allergen inactivation effect and cedar pollen allergen inactivation effect of commercially available activated clay (Mizuwa Chemical Industry Galleon Earth SH). In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Comparative Example 1 Crystalline Magnesium Silicate

An amorphous magnesium silicate (SiO ₂ /MgO=3.9) was obtained by filtering, washing with water, drying and pulverizing the precipitate obtained using magnesium sulfate and water glass as raw materials. Table 1 shows the results of measuring the tick allergen inactivation effect and cedar pollen allergen inactivation effect by the average particle diameter, water content, acid strength, and ELISA method of the obtained crystalline magnesium silicate. In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

<Comparative Example 2> γ-type zirconium phosphate

A zirconium carbonate aqueous solution was added to a 75% phosphoric acid aqueous solution, and after heating and refluxing at 98 degreeC for 24 hours, the precipitate was filtered, washed with water, dried, and pulverized, and gamma-type zirconium phosphate was obtained. Table 1 shows the results of measuring the tick allergen inactivation effect and the cedar pollen allergen inactivation effect by the average particle diameter, water content, acid strength, and ELISA method of the obtained γ-type zirconium phosphate. In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Comparative Example 3 NASICON Type Zirconium Phosphate

After adding oxalic acid and 75% phosphoric acid aqueous solution to the aqueous solution of zirconium oxychloride, further adjusting the pH to 2.7 with caustic soda, heating and refluxing at 98 ° C for 12 hours, and filtering the precipitate, washing with water, drying and pulverizing the NASICON zirconium phosphate Got. Table 1 shows the results obtained by measuring the tick allergen inactivation effect and cedar pollen allergen inactivation effect by the average particle diameter, water content, acid strength, and ELISA method of the obtained NASICON zirconium phosphate. In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Comparative Example 4 Titanium Oxide

Table 1 shows the results obtained by measuring the average particle diameter, acid strength, and tick allergen inactivation effect and cedar pollen allergen inactivation effect of commercially available titanium oxide (MC-50 manufactured by Ishihara Industries). In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Comparative Example 5 Activated Alumina

Table 1 shows the results obtained by measuring the average particle diameter, acid strength, and tick allergen inactivation effect and cedar pollen allergen inactivation effect of commercially available activated alumina (Mizuwa Chemical Industry GNDY-2). In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Comparative Example 6 Silica-alumina

Silica-alumina was adjusted by pulverizing at 98 degreeC using water glass and aluminum nitrate as a raw material, and calcining the obtained precipitate at 400 degreeC. Table 1 shows the results obtained by measuring the tick allergen inactivation effect and cedar pollen allergen inactivation effect by the average particle diameter, water content, acid strength, and ELISA method of the obtained silica-alumina. In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Comparative Example 7 Aluminum Phosphate

Table 1 shows the results obtained by measuring the average particle diameter, acid strength, and tick allergen inactivation effect and cedar pollen allergen inactivation effect of commercially available aluminum phosphate (Teka K-WHITE 105). In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

Comparative Example 8 Hydrotalcite

Table 1 shows the results obtained by measuring the average particle diameter, acid strength and commercially available hydrotalcite (HT-P manufactured by Sakai Chemical Industries Co., Ltd.) and the tick allergen inactivation effect and cedar pollen allergen inactivation effect. In addition, the result of having measured the color tone, pH of 5 wt% aqueous dispersion, the coloring property of a PP plate, and metal corrosion property is shown in Table 2.

From the results of Table 1, all of the inorganic powders having an acid concentration of 0.001 mmol / g or more of the present invention showed a tick allergen inactivation rate of 99% or more. In particular, amorphous magnesium silicate having an acid concentration of 0.07 mmol / g exhibits an allergen inactivation rate greater than 99%, and is very excellent as an antiallergic agent.

In the case of cedar pollen allergens, as in the case of tick allergens, the antiallergic agent of the present invention shows a high allergen inactivation rate and is excellent as an antiallergic agent. On the contrary, in the comparative example where the acid concentration was 0.001 or less, almost no allergen activity was shown.

In addition, from the result of Table 2, in the dispersion liquid of Example 4 and the comparative example 4, pH of 5 wt% dispersion liquid became smaller than 3, and showed metal corrosiveness.

Example 7 Anti-allergen Activity Evaluation of Example 1 Fixed to Fibers

Amorphous magnesium silicate, an inorganic substance of Example 1, and an acrylic emulsion binder (NW-7060 manufactured by Toa Synthetic Co., Ltd., solid content concentration: 50 wt%) were mixed so as to be 2: 1 by solid mass ratio, and fabric (component: cotton / acrylic fiber = 1/1) was immersed for 5 minutes, and the drying process was performed at 120 degreeC for 30 minutes, and the antiallergen cloth of fixed amount 1 g / m <2> of amorphous magnesium silicate was produced. Table 3 shows the results of measuring cedar pollen allergen inactivation effect of antiallergen cloth.

<Example 8> Antiallergen activity evaluation of Example 1 fixed to a fiber

Amorphous magnesium silicate, which is the inorganic substance of Example 1, was mixed so as to be 2: 1 by mass ratio of (NW-7060 manufactured by Toa Synthetic Co., Ltd., solid content concentration 50 wt%) and solid content, and fabric (component: cotton / acrylic fiber = 1 //). After 1 minute immersion in 1), drying was performed at 120 degreeC for 30 minutes, and the anti-allergen cloth of fixed amount 2g / m <2> was produced. Table 3 shows the results of measuring cedar pollen allergen inactivation effect of antiallergen cloth.

Comparative Example 9 Evaluation of Anti-allergen Activity When Example 1 was Not Fixed in Fiber

A comparative cloth was produced by the same processing method as in Example 7 without using amorphous magnesium silicate as the inorganic material of Example 1. The result of having measured the cedar pollen allergen inactivation effect of the comparative cloth is shown in Table 3.

From the results of Table 3, the anti-allergen processed cloth which impregnated amorphous magnesium silicate of Example 1 showed that the allergen inactivation rate is larger than 99%. Therefore, the performance of the anti-allergen product which processed the inorganic substance of this invention to the fiber is excellent.

&Lt; Example 9 >

Evaluation of the heat resistance of Example 1 fixed to the fiber

The antiallergen cloth was produced by the method similar to Example 7, and after heat-processing at 120 degreeC for 100 hours, the result which measured cedar pollen allergen inactivation effect and discoloration of antiallergen cloth was shown in Table 4.

&Lt; Example 10 >

Evaluation of the heat resistance of Example 1 fixed to the fiber

The antiallergen cloth was produced by the method similar to Example 8, and after heating at 120 degreeC for 100 hours, the result which measured cedar pollen allergen inactivation effect and discoloration of antiallergen cloth was shown in Table 4.

From the results of Table 4, the anti-allergen-processed fabric impregnated with the amorphous magnesium silicate of Example 1 exhibited a sufficiently high allergen inactivation rate even when heated for a long time, and no discoloration occurred. Post-processed anti-allergen products are also excellent in heat resistance.

<Example 11> Water resistance evaluation of Example 1 fixed to a fiber

In the same manner as in Example 7, an antiallergen cloth was prepared, placed in a plastic container, and ion exchanged water was added thereto, shaken at 25 ° C for 16 hours, and dried at 120 ° C for 30 minutes. Table 5 shows the results of measuring the effects.

<Example 12> Water resistance evaluation of Example 1 fixed to a fiber

An antiallergen cloth was prepared in the same manner as in Example 8, placed in a plastic container, ion exchanged water was added thereto, shaken for 16 hours at 25 ° C, and dried at 120 ° C for 30 minutes. Table 5 shows the results of measuring the effects.

From the results of Table 5, the anti-allergen processed cloth impregnated with amorphous magnesium silicate of Example 1 exhibited a sufficiently high allergen inactivation rate even after water treatment. Therefore, the anti-allergen product which processed the inorganic substance of this invention to the fiber is excellent also in water resistance.

&Lt; Example 13 >

Evaluation of antiallergen activity of Example 1 kneaded into a resin

Amorphous magnesium silicate as an inorganic substance of Example 1 and powdered polypropylene were mixed so as to have a solid content ratio of 10:90, and heated and pressed at 220 ° C. to produce an anti-allergen film having a film thickness of 0.2 mm. Table 6 shows the results of measuring cedar pollen allergen inactivation effect of the anti-allergen film.

&Lt; Example 14 >

Evaluation of antiallergen activity of Example 1 kneaded into a resin

Amorphous magnesium silicate as an inorganic substance of Example 1 and powdered polypropylene were mixed at a solid content ratio of 20:80 and heated at 220 ° C. to produce an anti-allergen film having a film thickness of 0.2 mm. Table 6 shows the results of measuring cedar pollen allergen inactivation effect of the anti-allergen film.

&Lt; Comparative Example 10 &

Evaluation of antiallergen activity when the resin was not kneaded in Example 1

A comparative film was produced by the same processing method as in Example 13 without using amorphous magnesium silicate as the inorganic material of Example 1. Table 6 shows the results of measuring cedar pollen allergen inactivation effect of the comparative film.

From the results of Table 6, the anti-allergen processed film obtained by kneading the amorphous magnesium silicate of Example 1 exhibited high allergen inactivation rate by adding 20 wt%. Therefore, the performance of the anti-allergen product which knead | processed the inorganic substance of this invention to resin is excellent.

&Lt; Example 15 >

Antiallergen Activity Evaluation of Example 1 Processed by UV Curing Resin

Amorphous magnesium silicate, an inorganic substance of Example 1, and an acrylic UV cured paint (solvent-free) were mixed in a solid content ratio of 15:85, and a bar coater was coated on a PET film (Toray Lumirror T60-50) with a thickness of 15 μm. Was processed using a high-pressure mercury lamp (intensity 60 W / cm) at a distance of 25 cm, and was irradiated with ultraviolet light under conditions of a conveyor speed of 3.7 m / min to cure the composition to produce an antiallergen film. Table 7 shows the results of measuring cedar pollen allergen inactivation effect of the anti-allergen film.

&Lt; Example 16 >

Antiallergen Activity Evaluation of Example 1 Processed by UV Curing Resin

Amorphous magnesium silicate, an inorganic substance of Example 1, and an acrylic UV cured paint were mixed so as to have a solids mass ratio of 30:70, and processed into a PET film (Toray Lumirror T60-50) by a bar coater to a thickness of 15 μm. , Using a high-pressure mercury lamp (intensity 60 W / cm) at a distance of 25 cm, was irradiated with ultraviolet light under conditions of a conveyor speed of 3.7 m / min, the composition was cured to produce an anti-allergen film. Table 7 shows the results of measuring cedar pollen allergen inactivation effect of the anti-allergen film.

&Lt; Comparative Example 11 &

Evaluation of anti-allergen activity of the film processed by the acrylic UV curing paint in the case of not fixing Example 1

A comparative film was produced by the same processing method as in Example 15 without using amorphous magnesium silicate as an inorganic material of Example 1. Table 7 shows the results of measuring the cedar pollen allergen inactivation effect of the comparative film.

From the result of Table 7, the antiallergen film which UV-hardened the amorphous magnesium silicate of Example 1 showed the high antiallergen inactivation rate. Therefore, the performance of the anti-allergen product which UV-hardened the inorganic substance of this invention on the surface is excellent.

&Lt; Example 17 >

In order to evaluate anti-allergenicity in a practical use environment, amorphous magnesium silicate, which is an inorganic substance, was prepared using an acrylic emulsion binder (NW-7060 manufactured by Toa Synthetic Co., Ltd., solid content concentration: 50 wt%) and a solid content by the method according to Example 8. After mixing for 5 minutes in a bath towel (155 cm x 70 cm component: cotton), the mixture was mixed at a mass ratio of 2 to 1, and then dried at 120 ° C. for 60 minutes to give a fixed amount of 2 g / m 2. An allergen cloth (bath towel) was produced.

In the clear sky scattered with cedar pots, dried towels in the sun for 6 hours in the clothesline to adsorb the cedar pots floating in the environment. After stopping overnight, the cleaner which set the nonwoven fabric was operated to the whole surface of a bath towel, and the allergen was suction-recovered on the nonwoven fabric. Allergens deposited on the nonwoven fabric were extracted with 10 ml of an antigen dilution solution (0.1% BSA + PBS buffer), and the amount of cedar pollen allergen (Cryj1) was measured by ELISA to obtain an allergen recovery amount. Since the amount of scattering of the natural cedar pollen varies greatly depending on the climate and the day, the same adsorption test was carried out three times on another sunny day at intervals of three days or more, and the results of the allergen recovery amount are shown in Table 8. The meaning on the 1st, 2nd and 3rd day of Table 8 means that the adsorption test was performed on three different days.

&Lt; Comparative Example 12 >

A bath towel of Comparative Example 12 was prepared in the same manner as in Example 17, except that only a binder containing no amorphous magnesium silicate was used, and the cedar pots floating in the environment at the same place in the same place as in Example 17 were adsorbed. . Table 8 shows the results of the allergen recovery.

In the comparison of the same day, since the amount of cedar pollen adhered to the bath towel of Example 17 and the bath towel of Comparative Example 12 was considered to be about the same, compared with the bath towel of Comparative Example 12 which does not have amorphous magnesium silicate, amorphous magnesium silicate The recovery amount of cedar pollen allergens of the bath towel of Example 17, in which was fixed was considered to be remarkably low, because the allergens of the attached cedar pollen were inactivated by amorphous magnesium silicate in the bath towel of Example 17.

Industrial availability

By using the anti-allergic agent of the present invention, it is possible to impart a function of inactivating allergens derived from pollen or ticks to materials related to human living spaces such as textile products and residential building materials, thereby producing anti-allergen products. Can be.

Claims (9)

The antiallergic agent which consists of inorganic powder whose acid concentration of the acid point whose pKa is 4.8 or less is 0.001 mmol / g or more and 10 mmol / g or less. The method of claim 1,
The anti-allergic agent measured by the laser particle size distribution meter and the median diameter of the inorganic powder calculated on a volume basis is 0.01 micrometer or more and 50 micrometers or less. 3. The method according to claim 1 or 2,
The anti-allergic agent whose pH of the 5 wt% aqueous dispersion of inorganic powder is 3 or more and 9 or less. The method according to any one of claims 1 to 3,
An anti-allergic agent, wherein the inorganic powder is at least one selected from amorphous magnesium silicate, α-type zirconium phosphate, and activated titanium oxide. 5. The method of claim 4,
An antiallergic agent wherein the inorganic powder is amorphous magnesium silicate. The coating composition containing the antiallergic agent and binder or coating material of any one of Claims 1-5. The method according to claim 6,
Coating composition whose pH is 3 or more and 9 or less. An antiallergen product processed by the coating composition according to claim 6. An antiallergen cloth processed by the coating composition according to claim 6.