JP6717772B2 - Anti-allergen composition and fiber/nonwoven fabric or fiber/nonwoven fabric product treated with the composition - Google Patents

Description

The present invention relates to an anti-allergen composition for inactivating a pollen-causing allergen-causing substance or for imparting a function of inactivating a allergen-causing substance to a fiber/nonwoven fabric product and a fiber treated with the composition. -Regarding non-woven fabrics or fibers/non-woven fabric products.

In recent years, it has become apparent that many people are suffering from various allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis. For the treatment of allergic diseases, administration of antiallergic agents and removal of allergens are mainly performed.
The allergen is removed using an electric vacuum cleaner, a wet wiper, an air cleaner, etc., but it is impossible to completely remove it by any method.

Further, as a method for reducing or removing allergen, a method using tannic acid as an inactivating agent for allergen (Patent Document 1), tea extract, hydroapatite, epicatechin, epigallocatechin, epigallocatechin gallate , A method of using gallic acid or an ester of gallic acid and an alcohol having 1 to 4 carbon atoms as an allergen inactivating agent has been proposed (Patent Document 2). However, the anti-allergen composition used in these methods has a problem that when it is attached to a fiber/nonwoven fabric or a fiber/nonwoven fabric product, it causes coloration or discoloration over time.
Further, a method of using an aluminum salt or an alkaline earth metal salt as an allergen inactivating agent (Patent Document 3, Non-Patent Document 4) has also been proposed, but the sufficient effect was not obtained.

JP-A-61-44821 JP-A-6-279273 JP-A-2003-334240

Sumitomo Chemical Journal 2009-II Development of allergen reducing agent

The present invention has a sufficient effect as an anti-allergen composition, and an anti-allergen composition capable of effectively reducing the allergen without damaging or damaging the appearance of the substrate to which the allergen is attached, and It is an object to provide a fiber/nonwoven fabric or a fiber/nonwoven fabric product treated with the composition.

As a result of earnest research for solving the above problems, the compound represented by the following chemical formula (1)
It has been found that the effect is higher than other metal phosphinic acid salt compounds such as calcium phosphinate, sodium phosphinate and magnesium phosphinate and aluminum compounds such as aluminum sulfate, aluminum chloride, aluminum phosphate and aluminum hydroxide. That is, the present inventors have found that a composition containing a compound represented by the following chemical formula (1) shows a sufficient effect for inactivating an allergen, and is free from coloring and deterioration during processing into a fiber/nonwoven fabric. The present invention has been completed.

(In the formula, R _{1 and} R ₂ are hydrogen, an alkyl group having 1 to 6 carbon atoms or a phenyl group, and R _{1 and} R ₂ may be the same group. M is Al or Zn, and m is m. 2-3.)

That is, the present invention is as follows.
(1) An anti-allergen composition comprising a compound represented by the following chemical formula (1).

(In the formula, R _{1 and} R ₂ are hydrogen, an alkyl group having 1 to 6 carbon atoms or a phenyl group, and R _{1 and} R ₂ may be the same group. M is Al or Zn, and m is m. 2-3.)
(2) The anti-allergen composition according to (1), wherein the anti-allergen composition contains a solvent, and the compound represented by the chemical formula (1) is dissolved or dispersed in the solvent.
(3) The anti-allergen composition according to (1) or (2), wherein the anti-allergen composition contains a binder.
(4) A fiber/nonwoven fabric or a fiber/nonwoven fabric product, which is treated with the anti-allergen composition according to (3).
(5) The adhesion amount of the compound represented by the chemical formula (1) in the anti-allergen composition in the fiber/nonwoven fabric or the fiber/nonwoven fabric product is 1 to 10 g/m ² , which is characterized in (4). Fiber/nonwoven or fiber/nonwoven products.

Since the anti-allergen composition of the present invention comprises a compound represented by the following chemical formula (1) as an active ingredient, it effectively reduces the allergen without damaging or damaging the appearance of the substrate. You can

(In the formula, R _{1 and} R ₂ are hydrogen, an alkyl group having 1 to 6 carbon atoms or a phenyl group, and R _{1 and} R ₂ may be the same group. M is Al or Zn, and m is m. 2-3.)

Hereinafter, embodiments of the anti-allergen composition of the present invention will be described.
The anti-allergen component used in the present invention is a compound represented by the following chemical formula (1).

(In the formula, R _{1 and} R ₂ are hydrogen, an alkyl group having 1 to 6 carbon atoms or a phenyl group, and R _{1 and} R ₂ may be the same group. M is Al or Zn, and m is m. 2-3.)

The compound represented by the chemical formula (1) is usually colorless or white powder, and thus can be used without impairing the coloring property of the product.
The average particle size of the anti-allergen component of the present invention is preferably 1 to 50 μm, particularly preferably 2 to 20 μm. If the average particle size exceeds 50 μm, the dispersion stability may deteriorate, and if the average particle size is less than 1 μm, agglomerates may be generated or extreme thickening may occur.

The anti-allergen composition of the present invention may be mixed with a known anti-allergen component as long as the physical properties are not impaired. Examples of the anti-allergen component include hydroxybenzoic acid compounds or salts thereof, zirconium salts, aluminum salts, alkaline earth metal salts, rare earth metal salts, cationic compounds and the like.

The anti-allergen composition of the present invention is preferably used as a liquid composition by dissolving or dispersing the compound represented by the chemical formula (1) as the active ingredient in a suitable solvent.
Examples of the solvent include water, alcohols (methyl alcohol, ethyl alcohol, propyl alcohol, etc.), hydrocarbons (toluene, xylene, methylnaphthalene, kerosene, cyclohexane, etc.) ethers (diethyl ether, tetrahydrofuran, dioxane, etc.), Examples thereof include ketones (acetone, methyl ethyl ketone, etc.), amides (N,N-dimethylformaldehyde, etc.), and these can be used alone or as a mixture of two or more thereof.

The anti-allergen composition of the present invention contains a formulation auxiliary such as a dispersant, an emulsifier, a humectant, a thickener, an antioxidant, and an ultraviolet absorber in a range that does not impair the effectiveness of the allergen-reducing effect. In addition, a miticide, an antibacterial agent, a fungicide, a deodorant and the like may be added.

Nonwoven fabrics, woven fabrics, knitted fabrics and the like are used as the fiber substrate treated with the anti-allergen composition of the present invention, and in the present invention, paper is included in the nonwoven fabrics. The type of fiber material is not particularly limited, and synthetic fibers such as polyester, nylon, polyacrylonitrile, polypropylene, aramid and polyethylene, semi-synthetic fibers such as diacetate and triacetate, rayon, cotton, hemp, paper and the like. The cellulosic fibers, animal fibers such as wool, silk, and feathers, or inorganic fibers such as glass fibers and carbon fibers may be used alone or in combination. Further, the fabric weight of the treated fiber/nonwoven fabric or the fiber/nonwoven fabric product is generally 30 to 300 g/m ^2, but is not particularly limited.

When the antiallergen composition of the present invention is processed into fibers, papers, etc., softening agents, antibacterial agents, antifungal agents, insecticides, flameproofing agents, antistatic agents, water repellents, deodorants, far infrared rays. It is also possible to use together with a functional processing agent such as a radiation functional agent, an ultraviolet absorber, a dye, a dye fixing agent, a moisturizing agent, a moisture preventive agent, a cooling feeling processing agent, a negative ion processing agent, an aromatic agent, a microcapsule agent.

Examples of allergens targeted by the anti-allergen composition of the present invention include plant allergens such as pollen. The anti-allergen component of the present invention inactivates allergens by suppressing the reaction of these allergens with specific antibodies. As a particularly effective plant allergen, any kind of pollen allergen can be targeted, but it is particularly effective for cedar pollen, which causes many allergic diseases, in the dust and on the surface of clothes and bedding.

The use application of the anti-allergen composition of the present invention is not particularly limited, and for example,
Examples include daily necessities that serve as a hotbed for allergens in the living space. Examples of the above-mentioned daily necessities include tatami mats, carpets, floors (flooring), furniture (sofas, upholstered chairs, tables), (bedding beds, futons, sheets), in-car products (seats, child seats), kitchen products, baby products , Curtains, wallpaper, towels, clothing, plush toys, textiles, masks, air purifiers, etc.
Further, as the above-mentioned usage method, the effect can also be exhibited by pre-treating the above-mentioned daily necessities and the batting of the mat used for the above-mentioned daily necessities, fibers of carpets and other raw materials (resin, fibers) and the like. it can. Alternatively, it may be impregnated with a base material such as a fiber aggregate (woven cloth/nonwoven cloth) and used as a cleaning sheet.
Further, it can be applied to building interior materials, and can be used as, for example, a surface treatment agent, a coating agent, or a paint.

The method for treating the anti-allergen composition of the present invention into a fiber, a non-woven fabric or the like is not particularly limited, and examples thereof include padding, coating, kneading, etc., and the anti-allergen composition of the present invention is attached to the fiber, a non-woven fabric, etc. The binder is not particularly limited, and examples thereof include acrylic resin, silicon resin, urethane resin, vinyl chloride resin, and the like.
The amount of the compound represented by the chemical formula (1), which is the active ingredient in the anti-allergen composition of the fiber/nonwoven fabric or the fiber/nonwoven fabric product, is 1 to 10 g/m ² , preferably ² to 7 g/m ^2. , And more preferably 3 to 5 g/m ² . This is because if the adhesion amount is less than 1 g/m ² , a sufficient allergen reduction effect cannot be obtained, and if it is more than 10 g/m ² , the appearance and feel of the material may be impaired.

Hereinafter, the present invention will be described in detail with reference to Examples and Test Examples, but the present invention is not limited thereto.

[Test Example] Method for measuring reduction rate of Spiria allergen The inactivation efficacy of the product of the present invention against Spiria allergen was measured by a sandwich ELISA method. The measurement method was as follows. Cry J1 monoclonal antibody 013 diluted to 2 μg/mL with a phosphate buffer was added to an ELISA plate in an amount of 50 μL per well and allowed to stand at room temperature for 3 hours. Then, the plate was washed with a phosphate buffer containing 0.05% Tween 20, and 300 μL per well of a phosphate buffer containing 1% bovine serum albumin and 0.05% Tween 20 was added as a blocking solution to the ELISA plate. Let stand overnight at 4°C. Then, the ELISA plate was washed with a phosphate buffer containing 0.05% Tween 20.

Next, 50 μL of a cedar pollen allergen solution (purified cedar pollen antigen Cry J1 1 ng/mL) dissolved in a phosphate buffer solution that had been in contact with each test sample for 24 hours was collected and added, and allowed to stand at room temperature for 2 hours. .. Then, it was washed with a phosphate buffer containing 0.05% Tween 20. Peroxidase-labeled Cry J1 monoclonal antibody 053 diluted to 1 μg/mL with a phosphate buffer containing 1% bovine serum albumin and 0.05% Tween 20 was added at 50 μL per well, and the plate was allowed to stand at room temperature for 2 hours. Then, the ELISA plate was washed with a phosphate buffer containing 0.05% Tween 20, and 100 μL of a 3,3′,5,5′-tetramethylbenzidine (TMB) substrate solution was added to each well at room temperature. After reacting for 10 minutes, the reaction was stopped with 1N hydrochloric acid, and the absorbance at 450 nm was measured with a spectrophotometer for a microplate.
The Cry J1 concentration of the measurement sample was determined from the calibration curve similarly measured using Cry J1 diluted with a known concentration of phosphate buffer.

[Examples 1 to 7]
The chemical was adhered to the polyester tropical (100% polyester, basis weight: about 135 g/m ² ) by the dipping treatment so that the amount of active ingredient adhesion shown in Table 1 below was obtained, and the test was conducted in the test example. The lower level of Table 1 shows the effect of reducing allergens on the basis of the test.

[Comparative Examples 1 to 10]
The chemical was adhered to the polyester tropical (100% polyester, basis weight: about 135 g/m ² ) by the dipping treatment so that the active ingredient adhesion amount shown in Table 2 below was obtained, and the test was conducted in the test example. The lower part of Table 2 shows the effect of reducing allergens on the basis of the test.

[Examples 8 to 11]
The chemicals were adhered to the non-woven fabric (100% polyester, basis weight: about 44 g/m ² ) by the dipping treatment so that the active ingredient adhesion amounts shown in Table 3 below were obtained, and the test was conducted in the test examples. The lowering effect of Spiria allergen based on the test is shown in the lower part of Table 3.

[Examples 12 to 15]
The chemicals were adhered to the non-woven pile fabric (100% polyester, basis weight: about 280 g/m ² ) by the dipping treatment so that the amount of active ingredient adhesion shown in Table 4 below was obtained, and the test was conducted in the test example. The lowering effect of Spiria allergen based on the test is shown in the lower part of Table 4.

INDUSTRIAL APPLICABILITY The anti-allergen composition of the present invention has an excellent allergen-reducing effect, and can impart the allergen-reducing effect without impairing or damaging the appearance of a substrate such as fiber or nonwoven fabric.

Claims (6)

A composition for antiallergen , comprising a compound represented by the following chemical formula (1).
(In the formula, R _{1 and} R ₂ are hydrogen, an alkyl group having 1 to 6 carbon atoms or a phenyl group, and R _{1 and} R ₂ may be the same group. M is Al or Zn, and m is m. 2-3.) The compound represented by the chemical formula (1) is one kind or two kinds or more selected from aluminum phosphinate, aluminum phenylphosphinate, aluminum diethylphosphinate and zinc phosphinate. Composition for anti-allergen. The anti-allergen composition comprises a solvent, anti-allergen composition according to claim 1 or 2, characterized in that the compound represented by Formula (1) is dissolved or dispersed in the solvent. The anti-allergen composition for anti-allergen composition according to any one of claims 1 to 3, characterized in that it comprises a binder component. A fiber/nonwoven fabric for antiallergen or a fiber/nonwoven fabric product for antiallergen, which is treated with the composition for antiallergen according to any one of claims 1 to 4. Anti of claim 5, wherein the amount of adhesion of the compound represented by the chemical formula of the anti-allergen composition for the said fibers, nonwoven fabric or fiber-nonwoven products (1) is 1 to 10 g / m ² Allergen fibers/nonwovens or anti-allergen fibers/nonwovens products.