WO2012050156A1

WO2012050156A1 - Anti-allergen agent

Info

Publication number: WO2012050156A1
Application number: PCT/JP2011/073508
Authority: WO
Inventors: 喜直山田
Original assignee: 東亞合成株式会社
Priority date: 2010-10-14
Filing date: 2011-10-13
Publication date: 2012-04-19
Also published as: JPWO2012050156A1; CN103261357B; KR20130118881A; CN103261357A; KR101893232B1; US20130273798A1; JP5594367B2

Abstract

[Problem] Conventional tannic acid and polyphenol anti-allergen agents are known as anti-allergen agents capable of deactivating allergens such as mites and pollen, but these agents have inferior heat resistance and pose problems with coloration, discoloration, and elution. The purpose of the present invention is to provide an anti-allergen agent that has excellent heat resistance, shows no coloration, and has excellent water resistance and workability. [Solution] It was discovered that by using an inorganic substance having a high acid site concentration, with acid site concentration being defined as the number of acid sites having a pKa of 4.8 or less, it is possible to realize an anti-allergen agent that manifests strong anti-allergen effects, has excellent heat resistance and water resistance, shows little coloration, and has excellent workability.

Description

Antiallergen

The present invention relates to an anti-allergen agent comprising an inorganic powder having a specific acid point concentration, an anti-allergen composition containing the anti-allergen agent, and a product. Anti-allergens are sprayed and painted on textile products such as clothing, bedding, and masks, interior products such as filters, curtains, carpets, and furniture used in air cleaners and air conditioners, and automotive interior materials. Alternatively, by fixing to a surface layer of a building material such as wallpaper or flooring material, an effect of reducing allergen-causing substances due to ticks or pollen can be imparted.

In recent years, the number of people suffering from allergic diseases such as hay fever caused by cedar pollen and bronchial asthma, hay fever, allergic rhinitis, and atopic dermatitis due to house dust caused by ticks and the like has increased. It has become. As a treatment for these allergic diseases, a series of drugs called anti-allergic agents and inhalation or topical steroids have been developed and made great progress, but they are not radical treatment because they are not symptomatic. .

In addition, acaricides are generally used to control mites in house dust. Even after death, the allergens are gradually released as the worms decompose, so killing the mites does not inactivate the allergens. Also, the mask is used to prevent inhalation of pollen such as cedar, but the pollen adhering to the mask does not lose allergen activity, so there is a risk of inhalation by scattering again. .

To alleviate symptoms of allergic diseases or prevent new sensitization from these problems, allergens that cause allergic symptoms are removed from the living space before being aspirated into the human body or denatured. It is necessary to make them harmless.

¡As a method for removing allergens without using chemicals, there is a method of reducing allergens by physically removing floor accumulated dust and airborne dust with a vacuum cleaner or air cleaner. However, a large amount of allergen sucked by the electric vacuum cleaner is only stored in the dust bag, and there is a risk that the allergen is scattered again when the dust bag is discarded. In addition, it is difficult to completely remove the fine particulate matter by removal with an air cleaner, and there is a risk of re-entrainment.

Therefore, in recent years, antiallergen agents have been proposed that inactivate and detoxify reactive sites of harmful allergens with antibodies by effects such as adsorption and coating. For example, methods using tannic acid are disclosed in Patent Documents 1 and 2, Non-Patent Document 1, and the like. Patent Document 3 discloses polyphenols such as tea extract and gallic acid which are similar compounds of tannic acid. Is disclosed. However, organic allergen reducing agents such as tannic acid are chemically unstable, and when attached to fibers and textiles, they may be colored or discolored over time, or the environment may be caused by moisture, oil, solvent or washing. The problem is that it spills into the skin and soils clothes and causes skin irritation. For example, since Patent Document 1 discloses that tannic acid can be removed with distilled water, it is clear that tannic acid is lost if fibers treated with tannic acid are washed repeatedly. Therefore, it is problematic to use it as an anti-allergen for textiles and textile products that may be washed or touched directly, and it can be used for textile products that are exposed to human eyes due to problems such as color tone, heat resistance, and durability. There was a drawback that the target was limited. In order to improve such a defect, an antiallergen agent composed of an inorganic substance has been proposed. Patent Document 4 discloses that an allergen is adsorbed using an inorganic substance such as activated carbon. However, like activated carbon, adsorption is performed on the principle of physical adsorption due to a large porous specific surface area. In general, the substance has a low anti-allergen adsorption performance and has a problem that its use is limited because it is black. Patent Document 5 discloses that among inorganic substances, those having high solid acid strength are excellent in antiallergen activity. However, even if the substance exhibits the same solid acid strength, there may be a significant difference in allergen inactivation performance, and the higher the solid acid strength is, the higher the anti-allergen activity is not always. There wasn't. Furthermore, it has become clear that when a solid acid having a very high solid acid strength is used to perform fiber processing in an aqueous system, the metal part of the processing apparatus may corrode.

JP-A 61-44821 Japanese Patent Publication No. 2-16731 JP-A-6-279273 JP 2002-167332 A WO2009 / 044648 International pamphlet

In view of the above circumstances, the present invention is an anti-allergen agent composed of an inorganic substance having high anti-allergen performance, excellent heat resistance and processability, little coloration and not flowing out with water, preferably a coating composition It is an object of the present invention to provide an anti-allergen agent that hardly causes corrosion or discoloration of a mechanical device even when used as a product or a resin composition, and an anti-allergen composition and an anti-allergen product using the same.

As a result of intensive studies to solve the above problems, the present inventor has found that an inorganic powder having a pKa of 4.8 or less and an acid point concentration of 0.001 mmol / g or more exhibits high antiallergen activity, The present invention has been completed. The present invention is an anti-allergen agent comprising an inorganic powder having a pKa of 4.8 or less and an acid point concentration of 0.001 mmol / g or more, an anti-allergen composition using the anti-allergen agent, and an anti-allergen product.

The anti-allergen agent of the present invention not only exhibits a high anti-allergen activity compared to existing anti-allergen agents, but also is an inorganic substance, so it has excellent heat resistance and little coloration or discoloration, and will flow out with water. It is durable because there is no. Excellent antiallergenicity can be imparted to various products by a simple processing method.

The present invention will be described below.
The acid point concentration used in the anti-allergen agent of the present invention is the number of acid points or acidic centers on the surface of the solid, and can usually be expressed as the number per unit weight or unit surface area of the solid or the number of moles. The acid strength of the acid point that is included in the quantity of the acid point concentration can be expressed by pKa. The acid strength indicates the strength of the property that the acid point on the solid surface gives a proton to the base, or the property of receiving an electron pair from the base, and the property that gives a proton to the base as the pKa of the acid point is smaller, or The strength of accepting electron pairs from the base is increased, and the ability to adsorb and inactivate allergen proteins is increased.

However, since one acid point normally cannot adsorb other allergen proteins while adsorbing one allergen protein, even if the acid strength of each acid point is high, the quantity of acid points, ie, acid If the point concentration is low, saturation adsorption is reached immediately and sufficient antiallergen effect cannot be shown. When allergen protein is present in a large amount, a higher anti-allergen effect is exhibited if the quantity to be adsorbed, that is, the acid point concentration is high.

On the other hand, when the acid strength at the acid point is small, that is, when the pKa is large, the property of giving a proton to the base or the property of receiving an electron pair from the base is weakened. The ability of the acid sites to adsorb and inactivate allergen proteins decreases, so that it becomes difficult to sufficiently adsorb allergen proteins no matter how large the number of acid sites, that is, the acid site concentration. This balance is also related to the structure of the allergen protein and the compatibility between the basicity and the acid point. However, according to the result of examining the representative allergen protein in the present invention, the pKa of the acid point of the inorganic substance having an acid point is 4.8. In the following cases, the effect of inactivation was shown for any allergen protein, and the quantity of acid sites, that is, the acid site concentration and the anti-allergen effect were correlated regardless of the type of allergen protein. That is, it has been found that if an acid point concentration of a solid acid having an acid point pKa of 4.8 or less is measured, it can be used as an index of the antiallergen performance of the substance.

More specifically, in the anti-allergen agent of the present invention, the number of acid points of an inorganic substance powder having an acid point pKa of 4.8 or less is defined as the “acid point concentration” in the present invention, The larger this value, the higher the anti-allergen performance, which is a preferable anti-allergen agent. Specifically, those having an acid point concentration of 0.001 mmol / g or more are preferable. Although there is no upper limit that should not exceed the acid point concentration, since a powder of an inorganic substance exceeding 10 mmol / g is not generally known as a specific material, the usual upper limit is 10 mmol / g or less.

Measurement of the number of acid points with a pKa of 4.8 or less is obtained by applying a titration method using an indicator corresponding to a pKa of 4.8 to measure the total of all acid points with a pKa of 4.8 or less. The value is defined as the acid point concentration having a pKa of 4.8 or less. In the present invention, the acid point concentration is more preferably 0.01 mmol / g or more, and more preferably the acid point concentration is 0.05 mmol / g or more. In particular, an inorganic substance having an acid point concentration of 0.05 mmol / g or more has an excellent anti-allergen effect and exhibits a high effect on various allergen substances.

The acid point concentration can be determined by measuring the amount of base that reacts with the powder. There is a method of measuring in the liquid phase or gas phase, the measurement in the liquid phase is a titration method, the measurement in the gas phase is a gas chemical adsorption method, the adsorption / desorption amount of He or hydrogen gas and the adsorption / desorption amount of basic gas However, since the reaction between the anti-allergen agent and the allergen in the present invention is a liquid-mediated reaction, measurement by a titration method in a liquid phase is suitable.

The method for measuring the acid point concentration of the inorganic powder by the titration method in the liquid phase is as follows.
The inorganic powder dispersed in the nonpolar solvent is titrated with n-butylamine, and the end point of the titration is confirmed by the discoloration of the indicator. The indicator before the reaction exhibits a base type color, but when adsorbed on the inorganic powder, exhibits a conjugate acid type color. The acid point concentration is determined from the titration amount of n-butylamine required to return from the conjugate acid type color to the base type color. One solid acid point corresponds to one n-butylamine molecule. Since the titrating base must replace the indicator bound to the solid acid point, its basicity must be stronger than the basicity of the indicator. As an ordinary titration method, when an indicator is first added to the inorganic powder / benzene dispersion, the indicator shows an acidic color due to solid acidity, but it is preferable to allow sufficient time until the reaction is completed. Next, n-butylamine is dropped, and the acid point concentration is calculated from the amount of n-butylamine when the indicator color returns to the basic color.

More specifically, 0.5 g of inorganic powder is put into a 20 mL sample bottle, and 10 mL of benzene is added thereto and shaken lightly. Further, add 0.1N n-butylamine, which was added in 20 steps, and stir with a shaker. After 24 hours, add 0.5 mL of 0.1% indicator methyl red solution and observe indicator discoloration. The amount of n-butylamine added in the system with the largest amount of n-butylamine in which no discoloration of the indicator is confirmed is defined as the amount of base reacted with the acid point and expressed as the acid point concentration (mmol / g). N is also referred to as normality, and normality is a unit commonly used by those skilled in the art, defined by normality = molar concentration × acid number of one molecule.

An inorganic substance having a high acid point concentration is an individual having many acid points on its surface. Specific examples of the inorganic substance having a high acid point concentration include, but are not limited to, amorphous magnesium silicate, α-type zirconium phosphate, layered titanium phosphate, activated alumina, activated titania, and the like. .

In order to apply the anti-allergen agent in the present invention to various materials and forms, the preferable average particle size is 0.01 to 50 μm, more preferably 0.02 to 20 μm. A powder having an average particle size of 0.01 μm or more has an advantage of being easy to handle because it is difficult to re-aggregate. In addition, when the fiber is post-processed by dispersing in a binder or the like, particles having an average particle size of 50 μm or less have good dispersibility and do not impair the texture of the fiber. It is preferable because it has advantages such as being difficult to cause. The average value of the average particle diameter can be measured with a laser diffraction particle size distribution meter or the like, and the median diameter analyzed on a volume basis can be used as the representative value of the particle diameter.

The color tone of the anti-allergen agent in the present invention is not limited, but white or a light color with high brightness is preferable in order to apply it to various materials and forms. The preferred brightness is 60 or more in terms of L value as measured by a color difference meter.

Furthermore, the inorganic substance constituting the anti-allergen agent in the present invention preferably has an acid strength pKa of 1.5 or less. This is because, in addition to the high acid point concentration, the higher the acid strength as a solid acid, the higher the antiallergenicity. The acid strength of the anti-allergen agent in the present invention is the ability of the acid point on the surface of the anti-allergen agent to give a proton to the base or to receive an electron pair from the base. The acid strength can be measured by a method using an indicator. If an appropriate indicator is selected as the base, the acid strength can be measured as the ability to change the base type of the indicator to its conjugate acid type.

Examples of indicators and (pKa values) that can be used to measure acid strength include methyl red (+4.8), 4-phenylazo-1-naphthylamine (+4.0), dimethyl yellow (+3.3), 2 -Amino-5-azotoluene (+2.0), 4-phenylazo-diphenylamine (+1.5), 4-dimethylaminoazo-1-naphthalene (+1.2), crystal violet (+0.8), p-nitrobenzeneazo -P'-nitro-diphenylamine (+0.43), dicinnamylacetone (-3.0), benzalacetophenone (-5.6), anthraquinone (-8.2) and the like. The acid strength can be measured by using various acid-base conversion indicators with known acid strength (pKa). The more discolored indicator of pKa is, the higher its acid strength is.

The method for measuring the acid strength of an inorganic solid acid using the indicator is as follows.
Collect 0.1 g of solid acid in a test tube, add 2 mL of benzene and shake gently. Add 2 drops of 0.1% benzene solution of the indicator (however, crystal violet is not a benzene solution but a 0.1% ethanol solution) and shake gently to observe the color change. The acid strength of the solid acid is less than or equal to the strongest acid strength at which indicator discoloration was confirmed (ie, the lowest pKa value), and greater than the weakest acid strength at which indicator discoloration was not confirmed (ie, the highest pKa value). That is, the pKa value of the inorganic solid acid is expressed as (the highest pKa value where no discoloration is confirmed) to (the lowest pKa value where discoloration is confirmed). In addition, when there is no appropriate indicator indicating the lower limit (the lowest pKa value in which discoloration is confirmed) or less, and when there is no appropriate indicator indicating the upper limit (the highest pKa value in which discoloration is not confirmed), the value is larger. Is generally written as.

The inorganic substance in the present invention has a certain amount of water, so that an anti-allergen effect is easily exhibited. A preferable moisture content in the inorganic substance is preferably 0.5 wt% or more, more preferably 2 wt% or more, and further preferably 10 wt% or more. In addition, hygroscopic inorganic substances can be mixed with other materials or the moisture can be kept in the inorganic substance even if the atmospheric humidity changes, and the inorganic substance itself has the moisture necessary for allergen inactivation. Is excellent in terms of

The anti-allergen effect in the present invention can be evaluated by an ELISA sandwich method widely used as an antigen detection and quantification method, and can be displayed as the allergen inactivation rate (unit%) shown in <Formula 1>. is there. The initial allergen amount is the allergen amount used in the ELISA evaluation and evaluated without using the sample, and the residual allergen amount is the allergen amount after contact with the sample. The allergen inactivation in the present invention is to suppress the reaction of allergen with a specific antibody, and the higher the allergen inactivation rate, the better. Specifically, an allergen inactivation rate of 90% or more is preferable, and an allergen inactivation rate of 99% or more is more preferable.

Allergen inactivation rate = (1-residual allergen amount / initial allergen amount) × 100 (%) <Formula 1>

The usage form of the anti-allergen agent of the present invention is not particularly limited, and can be appropriately mixed with other components or combined with other materials depending on the application. For example, it can be used in various forms such as powder, powder-containing dispersion, powder-containing particles, powder-containing paint, powder-containing fiber, powder-containing paper, powder-containing plastic, powder-containing film, and powder-containing aerosol. If necessary, it can be used in combination with various additives or materials such as deodorants, antibacterial agents, antifungal agents, flameproofing agents, anticorrosives, fertilizers and building materials. In addition, allergens in living space can be prevented by adding to materials that may come into contact with humans, such as resin, paper, plastic, rubber, glass, metal, concrete, wood, paint, fiber, leather, and stone. It is possible to activate.

Among these methods of use, it is preferable to use the anti-allergen agent of the present invention as a coating composition containing a fixing agent (binder). In addition to the binder, an additive may be added to the coating composition, and the coating composition may be diluted with a solvent or water before being processed into products of various shapes. In the coating composition of the present invention, the larger the weight ratio of the anti-allergen agent / binder solid content, the more easily the effect is produced. On the other hand, the larger the weight ratio of the binder solid content, the more firmly fixed the anti-allergen agent and There are also favorable aspects. Accordingly, the weight ratio of the antiallergen agent / binder solids in the coating composition containing the antiallergen is preferably 90/10 to 30/70, more preferably 80/20 to 50/50.
When the coating composition is used after being diluted, the concentration of the anti-allergen agent contained in the composition is preferably 0.5 to 50% by mass, more preferably 1 in terms of easy dispersion and good storage stability. ~ 30% by mass. Usually, the anti-allergen effect is manifested by the contact of the anti-allergen agent and the allergen on the surface of the product of various shapes, so fixing the anti-allergen agent on the surface of the product by the coating composition Since a large effect can be obtained with a smaller amount of the anti-allergen than when used for the entire interior of the product, it is preferable.

Examples of the binder used in the coating composition of the present invention include the following. Natural resin, natural resin derivative, phenol resin, xylene resin, urea resin, melamine resin, ketone resin, coumarone / indene resin, petroleum resin, terpene resin, cyclized rubber, chlorinated rubber, alkyd resin, polyamide resin, Polyvinyl chloride, acrylic resin, vinyl chloride / vinyl acetate copolymer resin, polyvinyl acetate, polyvinyl alcohol, polyvinyl plastic, chlorinated polypropylene, styrene resin, epoxy resin, urethane and cellulose derivatives. . Of these, acrylic resins, polyvinyl chloride, and vinyl chloride / vinyl acetate copolymer resins are preferable. Among them, emulsion type resins are preferable because of low pollution and easy handling.
Also usable as additives are pigments such as zinc oxide and titanium oxide, dyes, antioxidants, light stabilizers, flame retardants, antistatic agents, foaming agents, impact resistance enhancers, glass fibers, metal soaps Lubricants such as lubricants, moisture-proofing agents and extenders, coupling agents, nucleating agents, fluidity improvers, deodorants, wood powder, antifungal agents, antifouling agents, rust preventives, metal powders, UV absorbers, UV shielding Examples thereof include agents.

As a method of processing fibers with the coating composition containing the anti-allergen agent of the present invention, there is a method of applying, dipping, or spraying a fiber or a fiber product with the coating composition as it is or diluted. There are no restrictions on the fibers that can be processed, for example, natural fibers such as cotton, silk and wool, synthetic fibers such as polyester, nylon and acrylonitrile, semi-synthetic fibers such as triacetate and diacetate, and viscose rayon. Recycled fibers and the like, and composite fibers using two or more of these fibers may be used. Moreover, it can be used also for the nonwoven fabric using polyethylene, a polypropylene, etc. The method of processing the anti-allergen agent of the present invention into a fiber or a fiber product is not particularly limited, but includes an immersion treatment, a printing treatment, a spraying treatment, etc., and the fiber is processed by drying the fiber containing the composition. Complete. The drying method can be any of natural drying, hot air drying, vacuum drying, etc., but is preferably a method using heat, preferably 40 ° C. to 250 ° C., preferably 50 ° C. to 180 ° C. for 1 minute to 5 hours, preferably The anti-allergen agent can be fixed to the fiber by drying for 5 minutes to 3 hours.

The effect can be exhibited when the amount of the anti-allergen agent of the present invention attached to the fiber or fiber product is 0.1 g or more per 1 m ^{2 of the} fiber or fiber product. On the other hand, it is preferably 20 g / m ² or less, more preferably 1 g to 10 g / m ² so as not to impair the physical properties and texture of the fiber or fiber product.

If the coating composition containing the anti-allergen agent of the present invention is too low in pH, it may corrode the metal of the production machine or cause deterioration of the processing solution or decrease in stability. Since the solid acid may be neutralized and the antiallergen effect may be reduced, the pH is preferably 3 or more and 9 or less when the coating composition is capable of pH measurement such as an aqueous system. The factor that determines the pH of the coating composition is the same as the pH of the aqueous dispersion of the inorganic powder, and is greatly affected by the pKa of the solid acid. In addition, the acid point concentration and the solubility of the anti-allergen agent itself are also included. It is difficult to predict because components other than the anti-allergen agent constituting the coating composition, hydrophilicity, and the coating composition are affected. However, if the pH is too low, the dispersion itself containing the coating composition becomes acidic. Therefore, if it adheres to a metal part such as a processing apparatus, rust is generated, and the effect of the dispersant is reduced, leading to precipitation of the dispersion.

In addition, when the coating composition containing the anti-allergen agent of the present invention is non-aqueous, used as a paint containing various paint components, or used as a resin composition containing an anti-allergen agent, the metal part that contacts in the same manner However, it has been found that a resin having a pH within a certain range in the aqueous dispersion test is less likely to cause rust and discoloration. As a test of such an aqueous dispersion system, it is a simple method to disperse the antiallergen agent in water and measure the pH. For example, the anti-allergen agent may be dispersed in deionized water so as to be 5 wt%, and the pH after stirring for 5 minutes with a stirrer at 25 ° C. may be measured using a glass electrode type pH meter. The pH at that time is preferably 3 or more and 9 or less. Coating compositions, paints, resins, and the like using such anti-allergen agents are preferable because they hardly cause metal corrosion or discoloration. In addition, since the paint is a composition intended for coating, it is a kind of coating composition, but not only for the purpose of fixing functional components such as anti-allergen agents but also for the cured coating film itself of the composition. A coating composition that maintains a certain level of strength and exhibits weather resistance, article surface protection and aesthetics is particularly called a paint.

The anti-allergen agent of the present invention can be used in a paint. Various additives may be added to the paint. The resin component of the paint includes oils and fats such as soybean oil, linseed oil, safflower oil and castor oil, natural resins such as rosin, copar and shellac, processed resins such as chroman resin and petroleum resin, alkyd resins and acrylic resins. , Epoxy resin, polyurethane resin, vinyl chloride resin, silicone resin, synthetic resin such as fluororesin, rubber derivatives such as chlorinated rubber and cyclized rubber, cellulose such as nitrified cotton (lacquer), acetyl cellulose, etc. Derivatives and the like. The paint pigments are (white) titanium, (black) carbon, (brown) bengara, (red) chrome vermilion, (blue) bitumen, (yellow) yellow lead, (red) iron oxide, etc. Content, extender pigments such as calcium carbonate, talc and barite powder, rust preventive pigments such as red lead, lead suboxide and cyamido lead, functional pigments such as aluminum powder and zinc sulfide (fluorescent pigment). In addition, paint additives include UV curing agents, plasticizers, dispersants, anti-settling agents, emulsifiers, thickeners, antifoaming agents, antifungal agents, antiseptics, anti-skinning agents, drying agents, and anti-sagging agents. Matting agents, antistatic agents, conductive agents, flame retardants, graffiti preventing agents and the like. Examples of the solvent for the paint include water, alcohol, paint thinner, lacquer thinner, polyurethane resin thinner, and the like. A paint can be prepared by combining these.

As a method of processing a substrate with a paint containing the anti-allergen agent of the present invention, a brush coating method, a roller method, or a spraying method is applied to a substrate prepared in advance with a liquid as it is or diluted. And iron coating method. Further, the coated paint may be cured by UV irradiation. There are various types of base materials that can be processed. For example, various plastics such as polyethylene, polyvinyl chloride, polyvinylidene chloride, polyvinyl alcohol, polypropylene, polyester, polycarbonate, polystyrene, polyacrylonitrile, cellophane, etc. , Joint materials such as PVC, modified silicon and urethane, metal, ceramic siding, porcelain, stoneware, pottery, glazed tile, marble, granite, glass and so on.

In the paint containing the anti-allergen agent of the present invention, if the anti-allergen agent / paint solid content weight ratio is 10/90 or more, an obvious effect is easily exhibited. Moreover, 50/50 or less is preferable at the point which does not impair the physical property, texture, etc. of the base material to apply | coat for economical reasons, or the point which does not impair the physical property, function, etc. of a coating material remarkably. Therefore, the anti-allergen agent / paint solid content weight ratio in the paint containing the anti-allergen agent of the present invention is preferably 10/90 to 50/50, more preferably 20/80 to 40/60.

An anti-allergen resin composition can be easily obtained by blending the anti-allergen agent of the present invention with a resin. There is no restriction | limiting in the kind of resin which can be used, Any of a natural resin, a synthetic resin, and a semi-synthetic resin may be sufficient, and any of a thermoplastic resin and a thermosetting resin may be sufficient. Specific resins may be molding resins, fiber resins, and rubber-like resins. For example, polyethylene, polypropylene, vinyl chloride, ABS resin, AS resin, MBS resin, nylon resin, polyester, polychlorinated resin. Vinylidene, polystyrene, polyacetal, polycarbonate, PBT, acrylic resin, fluororesin, polyurethane elastomer, polyester elastomer, melamine, urea resin, tetrafluoroethylene resin, unsaturated polyester resin, rayon, acetate Mold, acrylic, polyvinyl alcohol, cupra, triacetate, vinylidene and other molding or fiber resins, natural rubber, silicone rubber, styrene butadiene rubber, ethylene propylene rubber, fluorine rubber, nitrile rubber, chlorosulfonated polyethylene Rubber, Tajiengomu, synthetic natural rubber, butyl rubber, there is a rubber resin such as urethane rubber and acrylic rubber. In addition to the resin component, various additives can also be contained. Examples of additives that can be used include pigments such as zinc oxide and titanium oxide, dyes, antioxidants, light stabilizers, flame retardants, antistatic agents, foaming agents, impact strength enhancers, glass fibers, and metal soaps. Lubricant, moisture proofing agent and extender, coupling agent, nucleating agent, fluidity improver, deodorant, wood powder, antifungal agent, antifouling agent, rust preventive agent, metal powder, UV absorber, UV shielding agent, etc. Any of these can be preferably used.

Any known method can be adopted as a method for producing a resin composition by blending the anti-allergen agent of the present invention into a resin. For example, (1) using an additive for facilitating adhesion between the anti-allergen powder and the resin or a dispersant for improving the dispersibility of the anti-allergen powder, a pellet resin or a powder resin (2) A method of directly mixing with a mixer, (2) A method of mixing as described above, forming into pellets with an extrusion molding machine, and then blending the molded product into a pellet resin, (3) Antiallergen After the agent is molded into a high-concentration pellet using wax, the pellet-shaped product is blended with the pellet-shaped resin. (4) The anti-allergen agent is dispersed and mixed in a high-viscosity liquid such as polyol. There is a method of preparing a paste-like composition and then blending the paste into a pellet-like resin.

For the molding process of the above resin composition, all known molding techniques and mechanical devices can be used in accordance with the characteristics of various resins. Mixing and mixing while heating and pressurizing or depressurizing at an appropriate temperature or pressure. Alternatively, they can be easily prepared by a kneading method, and their specific operation may be carried out by a conventional method, such as a lump, sponge, film, sheet, thread or pipe, or a composite thereof. It can be molded into various forms. If the anti-allergen agent / resin solids weight ratio in the resin composition containing the anti-allergen agent of the present invention is 10/90 or more, an obvious effect is easily exhibited. Moreover, the point which does not impair the economical reason, the moldability of a resin composition, the physical property of a molded object, a texture, etc., 50/50 or less is preferable. Therefore, the solid weight ratio of the anti-allergen agent / resin composition in the resin composition containing the anti-allergen agent of the present invention is preferably 10/90 to 50/50, more preferably 20/80 to 40/60.

The anti-allergen agent of the present invention can be used in the form of the above composition, resin composition, and resin molded product, as it is or depending on the application where allergen reduction is required, or mixed with other components as appropriate. Or can be used in combination with other materials. For example, it can be used in any form such as powder, liquid dispersion, granular, aerosol, or liquid.

The anti-allergen agent of the present invention is used in various fields where allergen reduction is required, that is, indoor products, bedding, filters, furniture, in-car products, textile products, residential building products, paper products, toys, leather products. It can be used as toiletries, cosmetics and other products. For example, carpets, curtains, wall paper, tatami mats, shoji paper, wax for floors, calendars and other indoor products, bedding such as futons, beds, sheets, pillows, pillow covers, air purifiers, air conditioners Filters such as sofas, furniture such as chairs, car seats such as child seats and seat sheets, dust collection bags for vacuum cleaners, clothing, masks, stuffed animals, kitchen utensils, etc. However, the present invention is not limited to this.

Hereinafter, the present invention will be described in more detail by way of examples. However, the present invention is not intended to be limited to such examples.

The average particle diameter of the inorganic powder described in the examples indicates a volume-based median diameter obtained by ultrasonic dispersion in deionized water using a laser diffraction particle size distribution analyzer. Unless otherwise specified,% indicates mass%, but the unit% of the allergen inactivation rate is according to the above <Formula 1>.
To measure the acid point concentration, put 0.5 g of inorganic powder in a 20 mL sample bottle, add 10 mL of benzene to it, and shake gently. Add 0.1N n-butylamine, which was added in 20 steps, and stir on a shaker. After 24 hours, 0.5 mL of 0.1% methyl red solution diluted with benzene is added, and the color change of methyl red is visually observed. The amount of n-butylamine added in the largest amount of n-butylamine, in which no discoloration of methyl red was confirmed, was defined as the amount of base reacted with acid sites, and the acid point concentration (mmol / g).

To measure the acid strength, take 0.1 g of a sample in a test tube, add 2 mL of benzene and 2 drops of 0.1% benzene solution of the indicator (but 0.1% ethanol solution for crystal violet), and lightly Shake and observe color change. The acid strength is less than or equal to the strongest acid strength (lowest pKa value) at which discoloration of the indicator was confirmed, and is considered to be greater than the weakest acid strength (highest pKa) at which the indicator did not discolor, so the range is defined as the pKa value. As recorded. The indicators used were methyl red (pKa = 4.8), 4-phenylazo-1-naphthylamine (pKa = 4), dimethyl yellow (pKa = 3.3), 4-phenylazo-diphenylamine (pKa = 1. 5), crystal violet (pKa = 0.8), dicinnamylacetone (pKa = -3), benzalacetophenone (pKa = -5.6), anthraquinone (pKa = -8.2).

The moisture content of the inorganic powder was weighed about 5 g in an aluminum cup that had been weighed at 250 ° C. for 1 hour in a dryer (weighed to the nearest 0.1 mg), dried for 2 hours at 250 ° C. in the dryer, and then weighed again. (Weighed to the nearest 0.1 mg), and the water content of the inorganic powder was expressed as a percentage by dividing the drying loss by the mass before drying.

The anti-allergen effect was evaluated by the sandwich method of ELISA using a leopard mite allergen (allergen generally referred to as Derf2) and a cedar pollen allergen (allergen generally referred to as Cryj1). The test procedure when using leopard mite allergen is as follows. An antibody coat well was prepared by a conventional method using a persimmon leopard mite allergen (Derf2) -specific antibody (15E11 antibody, manufactured by Asahivir Co., Ltd.).
3 mg of the sample was weighed, and 500 μL of leopard mite allergen (Derf2) prepared to 40 ng / mL with an antigen diluent was added. The mixture was well stirred to bring the sample into contact with the allergen, and then centrifuged and collected. The supernatant was collected, added to the 15E11 antibody coat well treated with a blocking agent, and allowed to stand at room temperature. One hour later, the sample was discarded, each well was washed with a washing buffer, and horseradish peroxidase-labeled anti-Derf2 monoclonal antibody 13A4PO (Asahivir Co., Ltd.) diluted to 200 ng / mL with the washing buffer was added to each well. It was added to the well and allowed to stand at room temperature. After 1 hour, the antibody solution was discarded, each well was washed with a washing buffer, a substrate solution was added to each well, and the mixture was allowed to stand at room temperature. After 5 minutes, 2N sulfuric acid was added to stop the reaction, and the absorbance at 490 nm was measured. As a result, the relationship between the allergen amount with respect to the absorbance was obtained by evaluating without using the sample, the residual allergen amount was obtained from the absorbance when the various samples were evaluated, and various samples were obtained by calculating from the above <Formula 1>. % Of allergen inactivation was displayed.

The test procedure by ELISA sandwich method using cedar pollen allergen is as follows. An antibody coat well was prepared by a conventional method using a cedar pollen allergen (Cryj1) specific antibody (Anti-Cryj1mAb013 manufactured by Seikagaku Corporation).
3 mg of the sample was weighed, and 500 μL of cedar pollen allergen (Cryj1) prepared to 10 ng / mL with the antigen dilution solution was added. The mixture was well agitated to bring the sample into contact with the allergen, and then centrifuged to collect the supernatant. The supernatant was added to the anti-Cryj1 mAb013 antibody coat well treated with a blocking agent and allowed to stand at room temperature. One hour later, the sample was discarded, each well was washed with a washing buffer, and horseradish peroxidase-labeled anti-Cryj1 monoclonal antibody 053 (manufactured by Seikagaku Corporation) diluted to 250 ng / mL with the washing buffer was used. It added to each well and left still at room temperature. After 2 hours, the antibody solution was discarded, each well was washed with a washing buffer, a substrate solution was added to each well, and the mixture was allowed to stand at room temperature. After 5 minutes, 2N sulfuric acid was added to stop the reaction, and the absorbance at 490 nm was measured. As a result, the percentage of allergen inactivation of various samples was displayed by calculating from Equation 1 in the same manner as for the leopard mite allergen.

The pH of the aqueous dispersion of inorganic powder was dispersed in ion-exchanged water in a beaker so that the inorganic powder was 5 wt%, and the pH after stirring for 5 minutes with a stirrer at 25 ° C. was measured using a glass electrode pH meter. It measured using-.

In the resin molding discoloration confirmation test, 2 wt% of inorganic powder was mixed with polypropylene powder, and the plate was molded at 220 ° C. with an injection molding machine. The degree of coloring of the obtained plate was confirmed visually.

In the metal corrosion test, first, an iron test piece (width / length / thickness = 20/80/2 mm) was prepared, and the surface was washed with acetone. An iron test piece and an inorganic powder 5 wt% aqueous dispersion were placed in a glass test tube having a diameter of 30 mm, and placed on a heat block adjusted to 60 ° C. After 24 hours, the test piece was taken out, immersed in distilled water, subjected to ultrasonic cleaning for 5 minutes, and then dried for 30 minutes with a 50 ° C. dryer, and the presence or absence of rust on the test piece was visually confirmed.

The anti-allergen effect of the processed fiber product is that cedar pollen allergen (Cryj1) is used as the allergen, and 25 cm ² of fiber is put into a plastic bag with a chuck, and 1 mL of the allergen solution adjusted to 100 ng / mL is brought into contact with the sample for 1 hour. After that, the contact solution is spun down, the supernatant is collected, the absorbance is measured by the same ELISA method evaluation as that of the inorganic powder, and the anti-allergen inactivity according to the above formula 1 is compared with the absorbance when the sample is not used. % Conversion was evaluated.

Anti-allergen effect film kneading resins, allergens using cedar pollen allergen (Cryj1) to put the film 25 cm ² into a zippered plastic bag, 1 hour contacting the allergen solution 1mL adjusted to the sample and 10 ng / mL Then, the contact liquid is centrifuged and the supernatant liquid is collected, and the absorbance is measured by the same ELISA method evaluation as that of the inorganic powder. Compared with the absorbance when the sample is not used, anti-allergen resistance is determined by the above formula 1. The activation rate% was evaluated.

The anti-allergen effect of the film processed with the acrylic UV curable paint is the allergen solution using cedar pollen allergen (Cryj1) as the allergen, putting the film 25cm ² into a plastic bag with a chuck, and adjusting the sample to 10ng / mL. After contacting 1 mL for 3 hours, the contact solution is spun down, the supernatant is collected, the absorbance is measured by the same ELISA method as for inorganic powder, and the above formula is compared with the absorbance when no sample is used. The anti-allergen inactivation rate% was evaluated according to 1.

Example 1 Amorphous Magnesium Silicate Amorphous magnesium silicate (SiO ₂ / MgO =) by filtering, washing, drying and crushing a precipitate obtained using magnesium sulfate and water glass as raw materials. 1.3) was obtained. Table 1 shows the average particle size, water content, acid strength, and the mite allergen inactivation effect and the cedar pollen allergen inactivation effect measured by the ELISA method for the obtained amorphous magnesium silicate. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Example 2> α-type zirconium phosphate A 15% zirconium oxychloride aqueous solution was added to a 75% phosphoric acid aqueous solution and aged at 120 ° C. for 12 hours, and then the precipitate was filtered, washed with water, dried and crushed to obtain α-type. A zirconium phosphate powder was obtained. Table 1 shows the average particle size, water content, acid strength, and mite allergen inactivation effect and cedar pollen allergen inactivation effect measured by the ELISA method of the obtained α-type zirconium phosphate. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Example 3> A precipitate obtained by using titanyl sulfate and oxalic acid as an active titanium oxide raw material was filtered, dried, calcined at 500 ° C, and pulverized to prepare active titanium oxide. The average particle diameter, water content, acid strength and the mite allergen inactivating effect and the cedar pollen allergen inactivating effect measured by the ELISA method of the obtained titanium oxide are shown in Table 1. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Example 4> The average particle diameter, acid strength, and mite allergen inactivation effect and cedar pollen allergen inactivation effect of activated white clay (Galeon Ace SH manufactured by Mizusawa Chemical Industry) were measured. The results are shown in Table 1. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

Comparative Example 1 Crystalline Magnesium Silicate Amorphous magnesium silicate (SiO ₂ / MgO = 3) by filtering, washing, drying, and crushing a precipitate obtained using magnesium sulfate and water glass as raw materials. 9) was obtained. Table 1 shows the average particle diameter, water content, acid strength, and the mite allergen inactivating effect and the cedar pollen allergen inactivating effect measured by the ELISA method of the obtained crystalline magnesium silicate. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Comparative example 2> γ-type zirconium phosphate A zirconium carbonate aqueous solution was added to a 75% phosphoric acid aqueous solution, heated and refluxed at 98 ° C. for 24 hours, and then the precipitate was filtered, washed with water, dried and crushed to obtain γ-type phosphoric acid. Zirconium was obtained. Table 1 shows the average particle diameter, water content, acid strength, and mite allergen inactivation effect and cedar pollen allergen inactivation effect measured by ELISA method for the obtained γ-type zirconium phosphate. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Comparative Example 3> After adding oxalic acid and 75% phosphoric acid aqueous solution to NASICON type zirconium phosphate zirconium oxychloride aqueous solution, and adjusting pH to 2.7 with caustic soda, after heating and refluxing at 98 ° C for 12 hours The NASICON type zirconium phosphate was obtained by filtering, washing, drying and crushing the precipitate. Table 1 shows the results of measuring the mite allergen inactivating effect and the cedar pollen allergen inactivating effect by the average particle size, water content, acid strength, and ELISA method of the obtained NASICON-type zirconium phosphate. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Comparative Example 4> Titanium oxide Commercially available titanium oxide (MC-50 manufactured by Ishihara Sangyo Co., Ltd.) The average particle diameter, acid strength, and the results of measuring the mite allergen inactivation effect and the cedar pollen allergen inactivation effect by ELISA method It is shown in Table 1. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Comparative Example 5> Activated Alumina Results of measuring the mean particle diameter, acid strength, and mite allergen inactivation effect and cedar pollen allergen inactivation effect of commercially available activated alumina (Mizusawa Chemical Industry GNDY-2) by ELISA method Is shown in Table 1. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Comparative Example 6> Silica-alumina Using silica glass and aluminum nitrate as raw materials, stirring was performed at 98 ° C, and the resulting precipitate was calcined at 400 ° C and then pulverized to prepare silica-alumina. The average particle size, water content, acid strength, and mite allergen inactivating effect and cedar pollen allergen inactivating effect measured by the ELISA method for the obtained silica-alumina are shown in Table 1. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Comparative Example 7> Aluminum phosphate The average particle size, acid strength and ELISA method of mite allergen inactivation and cedar pollen allergen inactivation of commercially available aluminum phosphate (Taika K-WHITE 105) were measured. The results are shown in Table 1. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

<Comparative Example 8> Hydrotalcite The average particle size, acid strength and ELISA method of mite allergen inactivation effect and cedar pollen allergen inactivation effect of commercially available hydrotalcite (HT-P manufactured by Sakai Chemical Industry) The results are shown in Table 1. Table 2 shows the results of measurement of color tone, pH of 5 wt% aqueous dispersion, colorability of PP plate, and metal corrosivity.

From the results in Table 1, all the inorganic powders having an acid point concentration of 0.001 mmol / g or more according to the present invention showed a mite allergen inactivation rate of 99% or more. In particular, amorphous magnesium silicate having an acid point concentration of 0.07 mmol / g shows an effect of an allergen inactivation rate of more than 99%, and is very excellent as an antiallergen agent.
In the case of cedar pollen allergens, as in the case of mite allergens, the anti-allergen agent of the present invention exhibits a high allergen inactivation rate and is very excellent as an anti-allergen agent. In contrast, the comparative example having an acid point concentration of 0.001 or less showed almost no antiallergen activity.
Moreover, from the results of Table 2, the dispersions of Example 4 and Comparative Example 4 showed a metal corrosivity because the pH of the 5 wt% dispersion was less than 3.

<Example 7> Evaluation of anti-allergen activity of Example 1 fixed to fiber Amorphous magnesium silicate and acrylic emulsion binder (NW-7060 manufactured by Toagosei Co., Ltd., solid content concentration 50 wt%) of Example 1 ) With a solid content mass ratio of 2: 1, soaked in a cloth (component: cotton / acrylic fiber = 1/1) for 5 minutes, dried at 120 ° C. for 30 minutes, and then amorphous. An anti-allergen cloth having a fixed amount of 1 g / m ² of fine magnesium silicate was prepared. Table 3 shows the results of measuring the cedar pollen allergen inactivating effect of the anti-allergen cloth.

<Example 8> Antiallergen activity evaluation of Example 1 fixed to fiber Amorphous magnesium silicate (NW-7060, manufactured by Toagosei Co., Ltd., solid content concentration 50 wt%) and solids of Example 1 were solid and solid After mixing for 5 minutes in a cloth (component: cotton / acrylic fiber = 1/1), the mixture was dried at 120 ° C. for 30 minutes, and the fixed amount was 2 g / min. An m ² anti-allergen fabric was prepared. Table 3 shows the results of measuring the cedar pollen allergen inactivating effect of the anti-allergen cloth.

<Comparative Example 9> Anti-allergen activity evaluation in the case where Example 1 is not fixed to the fiber A comparative fabric was prepared by the same processing method as Example 7 without using amorphous magnesium silicate which is an inorganic substance of Example 1. did. Table 3 shows the results of measuring the cedar pollen allergen inactivating effect of the comparative cloth.

From the results in Table 3, it was shown that the anti-allergen-treated cloth with the amorphous magnesium silicate of Example 1 applied thereto had an allergen inactivation rate of more than 99%. Therefore, the performance of the anti-allergen product obtained by post-processing the inorganic substance of the present invention into a fiber is excellent.

<Example 9>
Evaluation of heat resistance of Example 1 fixed to fiber After producing anti-allergen cloth in the same manner as in Example 7 and applying heat at 120 ° C. for 100 hours, the anti-allergen cloth was inactivated by cedar pollen allergen and discolored. The results of measuring the properties are shown in Table 4.

<Example 10>
Evaluation of heat resistance of Example 1 fixed to fiber After producing anti-allergen cloth by the same method as in Example 8 and applying heat at 120 ° C. for 100 hours, the inactivation effect and discoloration of cedar pollen allergen of anti-allergen cloth The results of measuring the properties are shown in Table 4.

From the results of Table 4, the anti-allergen-processed cloth applied with amorphous magnesium silicate of Example 1 shows a sufficiently high allergen inactivation rate even when heat is applied for a long time, and no discoloration occurs. The anti-allergen product obtained by post-processing the inorganic substance of the present invention into a fiber has excellent heat resistance.

<Example 11> Water resistance evaluation of Example 1 fixed to fiber An anti-allergen cloth was prepared in the same manner as in Example 7, put into a plastic container, added with ion-exchanged water, and shaken at 25 ° C for 16 hours. Table 5 shows the results of measuring the cedar pollen allergen inactivating effect of the anti-allergen cloth dried at 120 ° C. for 30 minutes.

<Example 12> Water resistance evaluation of Example 1 fixed to fiber An anti-allergen cloth was prepared in the same manner as in Example 8, put into a plastic container, added with ion-exchanged water, and shaken at 25 ° C for 16 hours. Table 5 shows the results of measuring the cedar pollen allergen inactivating effect of the anti-allergen cloth dried at 120 ° C. for 30 minutes.

From the results in Table 5, the anti-allergen-processed cloth impregnated with amorphous magnesium silicate of Example 1 showed a sufficiently high allergen inactivation rate even after water treatment. Therefore, the anti-allergen product obtained by post-processing the inorganic substance of the present invention into a fiber has excellent water resistance.

<Example 13>
Anti-allergen activity evaluation of Example 1 kneaded into resin Amorphous magnesium silicate, which is an inorganic substance of Example 1, and powdered polypropylene are mixed so as to have a mass ratio of 10:90 at 220 ° C. Was heated and pressed to produce an antiallergen film having a thickness of 0.2 mm. Table 6 shows the results of measuring the cedar pollen allergen inactivating effect of the anti-allergen film.

<Example 14>
Anti-allergen activity evaluation of Example 1 kneaded into resin Amorphous magnesium silicate, which is an inorganic substance of Example 1, and powdered polypropylene were mixed at a solid content mass ratio of 20:80, and 220 ° C. Was heated and pressed to produce an antiallergen film having a thickness of 0.2 mm. Table 6 shows the results of measuring the cedar pollen allergen inactivating effect of the anti-allergen film.

<Comparative Example 10>
Anti-allergen activity evaluation when Example 1 was not kneaded into the resin A comparative film was prepared by the same processing method as Example 13 without using amorphous magnesium silicate which is an inorganic substance of Example 1. Table 6 shows the results of measuring the cedar pollen allergen inactivating effect of the comparative film.

From the results shown in Table 6, the anti-allergen-processed film obtained by kneading the amorphous magnesium silicate of Example 1 showed a high allergen inactivation rate by adding 20 wt%. Therefore, the performance of the anti-allergen product obtained by kneading the inorganic substance of the present invention into a resin is excellent.

<Example 15>
Evaluation of anti-allergen activity of Example 1 processed with UV curable resin Amorphous magnesium silicate, which is an inorganic substance of Example 1, and acrylic UV curable paint (no solvent) have a solid content mass ratio of 15:85 And then processed to a PET film (Toray Lumira T60-50) to a thickness of 15 μm using a bar coater, and a conveyor pressure using a high-pressure mercury lamp (strength 60 W / cm) at a distance of 25 cm. The composition was cured by irradiating with ultraviolet rays under a condition of 3.7 m / min to produce an anti-allergen film. Table 7 shows the results of measuring the cedar pollen allergen inactivating effect of the anti-allergen film.

<Example 16>
Anti-allergen activity evaluation of Example 1 processed with UV curable resin Amorphous magnesium silicate, which is an inorganic substance of Example 1, and acrylic UV curable paint are mixed so that the solid content mass ratio is 30:70. , Processed to a PET film (Toray Lumilar T60-50) with a thickness of 15 μm using a bar coater, and a conveyor speed of 3.7 m using a high-pressure mercury lamp (strength 60 W / cm) at a distance of 25 cm. The composition was cured by irradiating with ultraviolet rays under the conditions of / min to produce an anti-allergen film. Table 7 shows the results of measuring the cedar pollen allergen inactivating effect of the anti-allergen film.

<Comparative Example 11>
Evaluation of anti-allergen activity of a film processed with an acrylic UV curable paint when Example 1 is not fixed. Comparison is made by the same processing method as Example 15 without using amorphous magnesium silicate which is an inorganic substance of Example 1. A film was prepared. Table 7 shows the results of measuring the cedar pollen allergen inactivating effect of the comparative film.

From the results shown in Table 7, the anti-allergen film obtained by UV-curing the amorphous magnesium silicate of Example 1 showed a high anti-allergen inactivation rate. Therefore, the performance of the anti-allergen product in which the inorganic substance of the present invention is UV-cured on the surface is excellent.

<Example 17>
In order to evaluate the antiallergenicity in an actual use environment, an amorphous magnesium silicate which is an inorganic substance was converted into an acrylic emulsion binder (NW-7060 manufactured by Toagosei Co., Ltd., solid content concentration 50 wt. %) And the mass ratio of the solid content of 2: 1 are immersed in a bath towel (155 cm × 70 cm component: cotton) for 5 minutes, and then dried at 120 ° C. for 60 minutes, An anti-allergen cloth (bath towel) having a fixed amount of 2 g / m ² was prepared.
The cedar pollen floating in the environment was adsorbed on a sunny day with cedar pollen scattered by bathing a bath towel on the outdoor clothes for 6 hours. A vacuum cleaner with a nonwoven fabric set after standing overnight was applied to the entire surface of the bath towel, and the allergen was sucked and collected on the nonwoven fabric. The allergen placed on the nonwoven fabric was extracted with 10 ml of an antigen dilution solution (0.1% BSA + PBS buffer), and the amount of cedar pollen allergen (Cryj1) was measured by ELISA to obtain the allergen recovery amount. Since the amount of natural cedar pollen varies greatly depending on the weather and the day, Table 8 shows the results of allergen recovery by conducting the same adsorption test three times on another sunny day with more than three days. It was. The meaning of the first, second and third days in Table 8 means that the adsorption test was performed three different days.

<Comparative Example 12>
A bath towel of Comparative Example 12 was prepared in the same manner as in Example 17 except that only a binder containing no amorphous magnesium silicate was used, and it floated in the environment in the same place on the same day as Example 17. To adsorb cedar pollen. The results of the allergen recovery amount are shown in Table 8.

In the comparison on the same day, it is considered that the amount of cedar pollen adhering to the bath towel of Example 17 and the bath towel of Comparative Example 12 was approximately the same, so the bath towel of Comparative Example 12 having no amorphous magnesium silicate was used. In comparison, the amount of cedar pollen allergen recovered from the bath towel of Example 17 in which amorphous magnesium silicate was fixed was remarkably low. In the bath towel of Example 17, the attached cedar pollen allergen was amorphous. This is thought to be due to inactivation by magnesium silicate.

By using the anti-allergen agent of the present invention, it is possible to impart a function to inactivate allergens derived from pollen, mites, etc. to materials related to human living space such as textile products and housing building materials, Allergen products can be manufactured.

Claims

An antiallergen agent comprising an inorganic powder having an acid point concentration of pKa of 4.8 or less and an acid point concentration of 0.001 mmol / g or more and 10 mmol / g or less.
The anti-allergen agent according to claim 1, wherein the median diameter of the inorganic powder measured with a laser particle size distribution meter and calculated on a volume basis is 0.01 μm or more and 50 μm or less.
The antiallergen agent according to claim 1 or 2, wherein the pH of the 5 wt% aqueous dispersion of the inorganic powder is 3 or more and 9 or less.
The anti-allergen agent according to any one of claims 1 to 3, wherein the inorganic powder is at least one selected from amorphous magnesium silicate, α-type zirconium phosphate, and active titanium oxide.
The anti-allergen agent according to claim 4, wherein the inorganic powder is amorphous magnesium silicate.
A coating composition comprising the anti-allergen agent according to any one of claims 1 to 5 and a binder or paint.
The coating composition according to claim 6, wherein the pH is 3 or more and 9 or less.
An anti-allergen product processed by the coating composition according to claim 6 or 7.
An anti-allergen fabric processed with the coating composition according to claim 6 or 7.