KR20130083556A - Oral composition for sensitive teeth - Google Patents

Abstract

PURPOSE: An oral composition for sensitive teeth is provided to form a thin film on the surface of dentin by strongly binding alginic acid or alginate with calcium ions on dentinal tubules and the surface of the dentin and to easily delivery calcium or zinc micropowder onto the surface of the dentin. CONSTITUTION: An oral composition contains 0.1-5 wt% of alginic acid or a salt thereof and micropowder. The alginic acid or the salt is selected among alginic acid, an alkali metal salt, a triethanolamine salt, an ammonium salt, and a propylene glycol salt of alginic acid. The alkali metal salt is sodium alginate or potassium alginate. The micropowder contains calcium or zinc.

Description

Oral composition for sensitive teeth

The present invention relates to a composition for oral cavity having a symptomatic effect of aspirin (dental hypersensitivity teeth), and more particularly to an oral composition having an effect of preventing or alleviating symptoms by containing alginic acid or a salt thereof and a micropowder. It is about.

This symptom of tooth ache is sensitive when the dentin part of the exposed tooth comes into contact with cold air or irritating foods. This symptom is caused by the external exposure of many of the customs in the dentin of the tooth to the outside. See FIG. 1). Shiriny symptoms in teeth can range from mild to intense, persistent pain. In addition, since teeth are not regenerated due to their nature, taking analgesics or anti-inflammatory drugs are not a fundamental solution to the symptoms of ache, and various treatments have been developed to relieve symptoms of ache.

There are two types of symptomatic treatments: ivory tubule sealing and pulp nerve desensitization. The ivory capillary sealing method is a method of filling the exposed ivory tubules with resin or restoring the enamel lost by fluorine coating, etc. In the pulp nerve desensitization method, the neurotransmission is controlled by the proper ratio of sodium and potassium ions. In view of this, artificially increasing the content of potassium ions prevents the nerves from feeling pain. However, the treatment of these specialized treatments is a hassle to go to the dentist, the toothpaste for the patient who can treat or prevent the patient in everyday life is sold.

These toothpastes contain active ingredients useful for the two therapeutic methods. However, toothpaste which is composed of potassium diphosphate component and the like to exhibit pulp nerve desensitization effect is preferred because toothpaste having efficacy by ivory capillary sealing method, which shows relatively fast efficacy, is long because the effect time is 15 days long. It is becoming.

However, in the case of the conventional toothpaste sealing effect, the syringe contains a fine powder of the active ingredient in order to seal the dentinal tubules. In general, the thinning is quickly diluted in the process of brushing, and most of the washing is performed in the process of rinsing with water. Customs could not be sealed due to the wind, there was a problem that is exposed again.

Alginic acid, also known as seaweed, is a polysaccharide that makes up the cell membrane of brown algae. Salts of alginic acid are strongly bound to divalent ions such as calcium or zinc to form a gel.

In addition, there is a conventional patent using the characteristics of alginate to improve the oral retention in the oral cavity by using alginate as part of a caking agent and including active ingredients such as fungicides, anti-inflammatory agents, and anti-inflammatory agents. It is only used as part. In addition, in the case of US Patent No. 5,885,551, alginate acts as a capillary filling agent on the tooth surface to relieve dentinitis, but it is known that azirin is prevented by using alginic acid alone. There was a limit to using it more than% to start showing effect.

Accordingly, the present inventors have conducted research on the ivory capillary sealing technology, and found that when alginic acid or salt thereof containing micropowder can be adsorbed well on the tooth surface is used together, it has an excellent effect on the ivory capillary sealing. The present invention has been completed.

US Patent No. 5,885,551

Accordingly, an object of the present invention is to provide an oral composition containing alginic acid or a salt thereof as an active ingredient together with a micropowder, which is well adsorbed on the dentin surface of the tooth and effectively seals the dentin tubules, thereby preventing or alleviating the symptom. It is done.

In order to achieve the above object, the present invention provides a composition for oral cavity containing alginic acid or a salt thereof and a micropowder together.

In addition, the present invention provides a composition for preventing or alleviating oral cavity, which contains an alginate or a salt thereof and a micropowder which may contain calcium or zinc, thereby effectively sealing the dentinal tubule of the tooth, which is the cause of the symptom. .

According to the oral composition of the present invention, the dentin surface of the tooth and the calcium ion of the dentin tube and the alginic acid or alginate contained in the present invention are strongly bound to form a thin film on the dentin surface and at the same time the calcium or zinc micropowder is dentin surface. You can pass on well. In addition, the fine powder contained in the present invention can effectively seal the ivory tubules.

In addition, since the present invention contains a mixture of alginic acid or a salt thereof and a micropowder, a small amount of alginic acid with respect to the total weight of the composition may effectively prevent or alleviate symptomatic symptoms.

1 is a view showing the dentin exposed to the dentin tubules.
Figure 2a to 2d is a view showing a SEM photograph taken to observe the degree of sealing of the ivory tubules according to the content of alginate.
3A to 3D are SEM photographs taken to observe the degree of sealing of the ivory tubule according to the amount of micropowder.

The present invention relates to an oral composition containing alginic acid or a salt thereof and a micropowder mixed together.

Hereinafter, the present invention will be described in detail.

The composition according to the present invention is a mixture of alginic acid or a salt thereof and a micropowder together, so that alginic acid or a salt thereof is strongly bonded to calcium ion and alginic acid or a salt thereof on the dentin surface of the tooth and the tubules to form a thin film on the dentin surface. At the same time, the fine powder is well transferred to the dentin surface, thereby effectively sealing the dentin tubule. Therefore, the effect of syringe is excellent in preventing or alleviating the symptoms.

Alginic acid or its salts include alkali metal salts such as sodium salts and potassium salts of alginic acid, triethanolamine salts, ammonium salts, propylene glycol salts, and the like, and sodium alginate is preferable. In addition, these can be used individually by 1 type or in combination of 2 or more types.

The alginic acid or a salt thereof is preferably contained in an amount of 0.01 to 10% by weight, and more preferably 0.1 to 5% by weight, based on the total weight of the composition. If alginic acid or salt thereof is contained in an amount less than 0.1% by weight based on the total weight of the composition, the micropowder may not be effectively delivered to the dentin surface. When the alginic acid or salt thereof is more than 5% by weight, the viscosity of the composition for oral cavity becomes so high that the usability is poor.

The fine powder is preferably a powder containing calcium or zinc as a component. There is no particular restriction on the kind, but it is preferably selected from the group consisting of calcium carbonate, calcium phosphate, calcium silicate, hydroxyapatite, zinc carbonate and zinc oxide, and powder containing calcium carbonate is more preferable.

When powder containing calcium or zinc is used, the micropowder interacts with alginic acid or its salts, so that the micropowder is well-transmitted to the dentin surface of the tooth by using alginic acid or its salt as a medium to prevent the symptom more effectively. I can alleviate it.

The particle diameter of the fine powder is preferably 1 nm to 100 um, more preferably 50 nm to 10 um. Since the average diameter of the ivory tubule of the tooth is 3 ~ 5um, if the particle size of the micropowder is less than 50 nm, the size of the powder may be too small to limit the ivory tubule, and if it exceeds 10um, the ivory tubule has an average diameter of 3 ~ 5um. Difficult to block tightly

In addition, the fine powder is preferably contained in 0.001 to 60% by weight, more preferably 5 to 40% by weight based on the total weight of the composition. If it is less than 5% by weight, the amount of micropowder is not enough to block the ivory tubules, and if it is more than 40% by weight, the viscosity of the composition is too high, making it difficult to use.

Hereinafter, the present invention will be described in detail through preferred examples and comparative examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the embodiments described below.

Test Example 1 Measurement of sealing degree of ivory tubule

In order to compare the degree of sealing of the ivory tubules, first, the toothpaste composition (Examples 1 to 3) as a mouthwash composition according to the present invention in a composition ratio as shown in Table 1 below and a conventional toothpaste composition for comparison thereto (Comparative Example 1 4) was prepared according to a conventional toothpaste manufacturing method.

More specifically, the water-soluble sodium monofluorophosphate, sodium saccharin, and preservatives were dissolved in purified water, and dissolved by adding sorbitol until it became transparent.Sodium alginate salt was dispersed in glycerin and mixed with water for 30 minutes to mix. . After the addition of 1 ~ 10um size of the fine powder was mixed for 30 minutes under reduced pressure, and finally prepared by adding the fragrance and sodium lauryl sulfate.

Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount antiseptic 0.2 0.2 0.2 0.2 0.2 0.2 0.2 glycerin 5 5 5 5 5 5 5 Sodium alginate One One One - One - One Sodium monofluorophosphate 0.76 0.76 0.76 0.76 0.76 0.76 0.76 Sorbitol 35 35 35 35 35 35 35 Sodium saccharin 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Calcium carbonate 20 - - - - 20 - Hydroxyapatite - 20 - - - - - Zinc carbonate - - 20 - - - - Silica - - - - - - 20 Sodium lauryl sulfate One One One One One One One Purified water Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount

(Unit: wt%)

After preparing the composition, the tooth of the human was extracted and cut in half in the longitudinal direction. Examples 1 to 3 and Comparative Examples 1 to 4 were applied to the dentin exposed tooth specimens, and then brushed with a brush machine for 1 minute, stored in artificial saliva for 15 minutes, and washed with purified water. After drying for 24 hours in an oven at 60 ℃ SEM was measured. The measurement of the perforated ivory tubule per unit area was performed using an image analyzer (Image-Pro PLUS, v 6.0, Media Cybernetics, Silver Spring, MD, USA). The area of ivory tubules perforated on the SEM images of the dental specimens was measured and shown in Table 2 below.

Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Area of Opened Ivory Customs
(Unit: um ² , average of 20) 1.01 1.18 1.43 5.61 5.15 5.15 3.55

As shown in Table 2, in Examples 1 to 3, the mouthwash containing sodium alginate salt and calcium or zinc micropowder effectively sealed the ivory tubules and found almost no perforated area. In particular, it was confirmed that the effect of the mouthwash containing calcium carbonate micropowder of Example 1 was the most excellent. On the other hand, in the case of Comparative Examples 2 and 3 containing only one of the fine powder or sodium alginate salt, the perforated area of the ivory tubule of Comparative Example 1 that does not contain both 5.61 um ² Compared with the reduction in area, the ivory capillary sealing effect was insignificant. In addition, in the case of Comparative Example 4, when the fine powder but the silica powder does not contain calcium or zinc, the fine powder is not effectively delivered to the dentin surface, so that the sealing effect of the ivory tubule is used when the fine powder containing calcium or zinc is used. It was confirmed that the fall significantly compared to.

Test Example 2 Effect Analysis of Alginate Salt Content

In order to analyze the effect by the alginic acid salt, a dentifrice composition containing carboxymethyl cellulose, which is a polymer commonly used in mouthwashes, in a composition ratio shown in Table 3 below was prepared using the preparation method used in Test Example 1.

And in Examples 3 to 6 and Comparative Example 5 of the following Table 3 to the teeth exposed dentin in the same manner as in Test Example 1 and measured the SEM. The area of ivory tubules perforated on the SEM specimens was measured and shown in Table 4 below, and the degree of sealing of ivory tubules was compared. In addition, the measured SEM picture is shown in Figures 2a to 2d.

Example 4 Example 5 Example 6 Comparative Example 5 Spices Suitable amount Suitable amount Suitable amount Suitable amount antiseptic 0.2 0.2 0.2 0.2 glycerin 5 5 5 5 Carboxymethyl Cellulose 0 0.5 1.0 1.5 Sodium alginate 1.5 1.0 0.5 0 Sodium monofluorophosphate 0.76 0.76 0.76 0.76 Sorbitol 35 35 35 35 Sodium saccharin 0.2 0.2 0.2 0.2 Calcium carbonate 20 20 20 20 Sodium lauryl sulfate One One One One Purified water Suitable amount Suitable amount Suitable amount Suitable amount

(Unit: wt%)

Example 4 Example 5 Example 6 Comparative Example 5 Area of Opened Ivory Customs
(Unit: um ² , average of 20) 1.03 1.79 3.53 4.73

As shown in Table 4, as the alginate content increased under the condition that the polymer content was fixed at 1.5%, the area of perforated ivory tubules decreased significantly. Also, as shown in FIGS. 2A to 2D, the fine powder adhered to the dentin surface more closely from FIG. 2D to FIG. 2A, so that the dentin tubule was covered by the composition. Therefore, it was confirmed that the sealing degree is improved as the content of the alginic acid salt increases.

[Test Example 3] Analysis of effects by content of fine powder

Sodium alginate salt was tested to determine the sealing effect of the ivory tubule according to the content of the fine powder in the state containing 1% by weight relative to the total weight of the composition.

 First, the toothpaste composition containing the composition ratio shown in Table 5 below was prepared using the manufacturing method used in Test Example 1. And Examples 7 to 9 and Comparative Example 6 of the following Table 5 was applied to the teeth exposed dentin in the same manner as in Test Example 1 and the SEM was measured. The area of ivory tubules perforated on the SEM specimens was measured and shown in Table 6 below, and the degree of sealing of ivory tubules was compared. In addition, the measured SEM picture is shown in Figures 3a to 3d.

Example 7 Example 8 Example 9 Comparative Example 6 Spices Suitable amount Suitable amount Suitable amount Suitable amount antiseptic 0.2 0.2 0.2 0.2 glycerin 5 5 5 5 Sodium alginate One One One One Sodium monofluorophosphate 0.76 0.76 0.76 0.76 Sorbitol 35 35 35 35 Sodium saccharin 0.2 0.2 0.2 0.2 Calcium carbonate 30 20 10 0 Sodium lauryl sulfate One One One One Purified water Suitable amount Suitable amount Suitable amount Suitable amount

(Unit: wt%)

Example 7 Example 8 Example 9 Comparative Example 6 Area of Opened Ivory Customs
(Unit: um ² , 20 averages) 0.96 1.01 3.13 5.15

As shown in Table 6, in the dentifrice composition containing 1% by weight of sodium alginate salt, the area of perforated ivory tubules was remarkably decreased as the content of fine calcium carbonate powder was increased as a fine powder. In particular, it could be seen that the effect no longer increases when the fine calcium carbonate powder is contained 20 wt% or more. Also, as shown in FIGS. 3A to 3D, the fine powder adhered to the dentin surface as shown in FIGS. Therefore, it was confirmed that the sealing degree was improved as the content of the fine powder was increased.

[Test Example 4] Measurement of the ivory capillary sealing effect in the mouse wash liquid formulation composition

In order to compare the sealing degree of the ivory tubules of the mouthwash solution formulation, the composition for comparison with the mouthwash solution composition according to the present invention (Example 10) and the composition as shown in Table 7 (Comparative Examples 7-9) Was prepared according to a conventional mouse wash solution preparation method.

More specifically, water-soluble sodium monofluorophosphate, sodium saccharin, and preservatives are dissolved in purified water, and dissolved by adding sorbitol until it becomes transparent, and then sodium alginate salt or carboxymethylcellulose is dispersed in glycerin and added to water parts. Mix for a minute. Thereafter, a solution of a premixed flavor and polyoxyethylene hydrogenated castor oil was added to prepare a mouse wash solution.

Example 10 Comparative Example 7 Comparative Example 8 Comparative Example 9 Spices Suitable amount Suitable amount Suitable amount Suitable amount Polyoxyethylene Hydrogenated Castor Oil 0.3 0.3 0.3 0.3 antiseptic 0.2 0.2 0.2 0.2 glycerin 5 5 5 5 Sodium saccharin 0.01 0.01 0.01 0.01 Sodium alginate One - One - Carboxymethyl Cellulose - - - One Sorbitol 10 0.76 0.76 0.76 Fine calcium carbonate 20 20 - - Purified water Suitable amount Suitable amount Suitable amount Suitable amount

(Unit: wt%)

After the composition was prepared, a human tooth was extracted and cut in half in the longitudinal direction. The dentin exposed tooth specimens were immersed in the mouse wash solution of Example 10 and Comparative Examples 7-9 for 3 minutes and then stored in artificial saliva for 30 minutes. Then, after drying for 24 hours in 60 oven SEM was measured. The perforated ivory tubule per unit area was measured using an image analyzer (Image-Pro PLUS, v 6.0, Media Cybernetics, Silver Spring, MD, USA).

Example 10 Comparative Example 7 Comparative Example 8 Comparative Example 9 Area of Opened Ivory Customs
(Unit: um ² , 20 averages) 1.91 5.02 5.16 4.28

As shown in Table 8, even when prepared in the mouse wash solution formulation, as shown in the case of manufacturing a toothpaste composition, the effect of the aspirin appeared. In Example 10, it was confirmed that the mouse wash solution containing sodium alginate salt and fine calcium carbonate powder effectively sealed the ivory tubules so that there was almost no perforated area. On the other hand, in the case of Comparative Example 7 and 8 containing only one of the fine powder or sodium alginate salt, the area was hardly reduced, it was confirmed that the ivory tubule sealing effect is insignificant. In addition, in the case of Comparative Example 9 it was confirmed that even when only containing carboxymethyl cellulose, not alginate, the sealing effect of the ivory tubule is significantly lower than the present invention.

As a result, the composition for oral cavity of the present invention was confirmed to have excellent ivory capillary sealing effect as well as the toothpaste formulation as well as the mouthwash solution formulation, which has an excellent antiviral or relieving effect.

Claims (9)

Alginic acid or its salt; And a composition for oral cavity containing micropowder. The composition for oral cavity according to claim 1, wherein the alginic acid or a salt thereof is at least one selected from the group consisting of alginic acid, alkali metal salts of alginic acid, creethanolamine salts, ammonium salts and propylene glycol salts. The oral composition according to claim 2, wherein the alkali metal salt of alginic acid is sodium alginate salt or potassium alginate salt. The composition for oral cavity according to claim 1, wherein the alginic acid or salt thereof is contained in an amount of 0.1 to 5 wt% based on the total weight of the composition. The oral composition of claim 1, wherein the micropowder is a powder containing calcium or zinc. 6. The composition for oral cavity according to claim 5, wherein the micropowder is one selected from the group consisting of calcium carbonate, calcium phosphate, calcium silicate, hydroxyapatite, zinc carbonate and zinc oxide. The composition for oral cavity of claim 1, wherein the micropowder has a particle diameter of 1 nm to 100 μm. According to claim 1, wherein the micropowder is oral composition containing 5 to 40% by weight based on the total weight of the composition. The composition for oral cavity according to any one of claims 1 to 8, wherein the composition is for preventing or alleviating the virus.

Images