KR100867613B1 - Oral composition for strengthening teeth - Google Patents

Abstract

An oral composition for strengthening tooth is provided to have an excellent effect by forming a water soluble film which continuously releases the tooth-strengthening component in a dental plaque. An oral composition for strengthening tooth contains a tooth strengthening component and a water soluble adhesive. The tooth strengthening component is selected from a group consisting of sodium fluoride, sodium monofluorophosphate, stannous fluoride and a mixture thereof. The water soluble adhesive is selected from a group consisting of gelatin, polyacrylic acid, polyvinyl alcohol, xanthan gum, sodium alginate, polyvinylpyrrolidone, polyvinylformamide, carboxymethyl cellulose and carboxypolymethylene.

Description

Oral composition for strengthening teeth}

The present invention relates to a fluorine coating agent excellent in tooth strengthening effect and easy to use. More specifically, the present invention relates to oral compositions for strengthening teeth in the form of gels that form a thin water-soluble film on the surface immediately after application to the teeth and are strongly adhered to effectively deliver and penetrate the tooth strengthening component deep into the tooth.

Dental caries, one of the diseases occurring in the oral cavity, is formed by the enlargement of the lesion caused by the dissolution of the tooth surface by the organic acid generated by the oral microorganisms inhabiting the tooth surface. Many compositions have been developed to prevent such dental caries and can be easily purchased and used anywhere in the form of toothpaste and mouthwash.

Compositions used to prevent dental caries are mainly used fluorine and calcium components to show the effect. In particular, fluorine is a representative ingredient that prevents dental caries, and there are many research results showing that dental caries may be reduced in regions where tap water fluoridation projects have been carried out worldwide. Fluoride is deposited on the surface of the tooth and is ultimately substituted with the hydroxyl group of hydroxyapatite, which is the structure of the tooth. have.

Due to this effect, the fluorine component is formulated in various toothpastes and mouthwashes currently on the market to seek the effect of preventing tooth decay. However, the Pharmacist Law recommends that the use limit be limited to less than 1000ppm due to the toxicity of fluorine.

European patent application 90906500 discloses a composition for reacting with a calcium salt to mix a hydrolyzable fluoride mixture. When the two components are mixed together, they form a precipitate called calcium fluoride as a result of hydrolysis of the fluorine component and adsorb on the tooth surface. However, calcium fluoride is formed quickly, but it has a disadvantage that it is not washed out before it is deposited on the surface of the tooth to form hydroxyapatite and thus does not sufficiently strengthen the tooth.

European patent application 98958469 discloses a composition for oral cavity in which reduced fluorine ions are delivered to the oral cavity of a person during tooth cleaning. The fluorine ions used at this time can be applied to liquids, gels and mixtures containing abrasives at 10 to 3500 ppm. However, in such a case, too high fluorine concentrations may be formulated and there may be a controversial hazard to humans.

Japanese Patent Application Laid-Open No. 1987-158831 seeks to mix fluorinated apatite with a substance that microcapsules or coats fluorine to prevent tooth decay. This ultimately forms a fluoride apatite to enhance the acid resistance of the tooth surface. However, when the size of the hydroxyapatite compounded together is not small, such as nano-size can not fill the lesion formed on the teeth and also has the disadvantage that the majority of the fern is washed away to form the desired fluoride apatite.

Domestic patent application 2002-0026946 relates to a tray for applying fluorine to teeth, which is based on cotton between the inner and outer skin of the mouthpiece type to improve the therapeutic effect without limiting the condition of the tooth and to be used conveniently. There is a need for a tray for applying fluorine to teeth made by embedding a fluoride filler impregnated with a disinfectant solution and a bleach. However, the tooth tray may cause discomfort when using a large amount of foreign matter on the tooth, and takes a long time of use.

Thus, the present inventors have studied the formulation to further enhance the tooth strengthening effect, when using a water-soluble polymer as a water-soluble adhesive in conjunction with the tooth strengthening component when the gel is applied to the teeth good applicability on the tooth surface and adhesion is good It has been found that the tooth strengthening component is sufficiently in contact with the tooth surface to obtain an excellent tooth strengthening effect.

Accordingly, it is an object of the present invention to provide a composition for oral cavity use that is convenient and effective in forming a water-soluble membrane for releasing tooth strengthening components evenly and continuously over a tooth surface.

In order to achieve the above object, the present invention is a tooth strengthening component selected from the group consisting of sodium fluoride, sodium monofluorophosphate, tin fluoride and mixtures thereof; And at least one water-soluble pressure sensitive adhesive selected from the group consisting of gelatin, polyacrylic acid, polyvinyl alcohol, xanthan gum, galang gum, sodium alginate, polyvinylpyrrolidone, polyvinylformamide, carboxymethylcellulose and carboxypolymethylene. It provides a composition for oral cavity to strengthen.

The oral composition for strengthening teeth is selected from the group consisting of sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, sodium citrate, sodium monophosphate, disodium phosphate, sodium triphosphate, sodium pyrophosphate and sodium metaphosphate At least one neutralizer; The polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyglyceryl fatty acid and fatty acid sugar ester may further contain one or more emulsifiers selected from the group consisting of.

In addition, the tooth strengthening component in the oral composition for tooth strengthening is 100 ~ 1000ppm based on the total weight of the composition; The water-soluble pressure-sensitive adhesive is 5.0 to 50.0% by weight based on the total weight of the composition; The neutralizing agent is 0.1 to 5.0% by weight based on the total weight of the composition; And the emulsifier is characterized in that it contains 0.01 to 3.0% by weight based on the total weight of the composition.

Oral composition for strengthening teeth according to the present invention has good applicability when applied to the teeth, increase the adhesion to the tooth surface and increase the contact time with the tooth strengthening component can be effectively delivered to the tooth strengthening component, less use It is very easy to use and useful because it shows excellent tooth strengthening effect even in time.

The composition for oral cavity for tooth strengthening according to the present invention contains a tooth strengthening component and a water-soluble adhesive as a fluorine coating agent, and may further contain components such as a neutralizer, an emulsifier, a solvent, a sweetener, a flavoring agent, and the like.

Oral composition for reinforcing teeth according to the invention is characterized in that the state of the gel.

Tooth strengthening component as a component of the composition for oral cavity strengthening according to the present invention may be used at least one selected from the group consisting of sodium fluoride, sodium monofluorophosphate, tin fluoride and mixtures thereof, but is not limited thereto. no. Such tooth strengthening component is preferably used in an amount of 100 ppm to 1000 ppm with respect to the total weight of the composition for oral cavity. If it is used below 100ppm, the effect of strengthening the tooth is less. If it is used over 1000ppm, the content of fluorine concentration determined by the pharmacist method is exceeded.

The water-soluble pressure-sensitive adhesive used as a component of the composition for oral cavity strengthening according to the present invention is for enhancing the adhesion of the composition to tooth enamel. The pressure-sensitive adhesive may be at least one selected from the group consisting of gelatin, polyacrylic acid, polyvinyl alcohol, xanthan gum, galang gum, sodium alginate, polyvinylpyrrolidone, polyvinylformamide, carboxymethyl cellulose and carboxypolymethylene. It may be used, but is not necessarily limited thereto. It is preferable to use such a water-soluble adhesive in the quantity of 5.0-50.0 weight% with respect to the total weight of the composition for oral cavity. If the amount is less than 5.0% by weight, the preparation of the composition is not only difficult, but also greatly reduces the adhesive ability, and when used in excess of 50.0% by weight, the pressure-sensitive adhesive may not be sufficiently dissolved to form a formulation.

The neutralizer used as a component of the composition for oral cavity strengthening according to the present invention is to neutralize the water-soluble adhesive to obtain an appropriate viscosity and to improve the safety of the teeth and oral mucosa. Such neutralizing agents include sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, sodium citrate, sodium monophosphate, sodium diphosphate, trisodium phosphate, sodium pyrophosphate, sodium metaphosphate, and the like. One or more selected from the group consisting of may be used, but is not necessarily limited thereto. Such neutralizing agent is preferably used in an amount of 0.1 to 5.0% by weight based on the total weight of the composition for oral cavity. If used in less than 0.1% by weight can greatly reduce the neutralization ability, when used in excess of 5.0% by weight may cause mucosal detachment by stimulating the oral mucosa.

The emulsifier used as a constituent of the composition for oral cavity strengthening according to the present invention is for uniformly emulsifying the constituents of the composition. Such emulsifiers may be one or more selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyglyceryl fatty acids and fatty acid sugar esters, but are not necessarily limited thereto. Such emulsifier is preferably used in an amount of 0.01 to 3.0% by weight based on the total weight of the composition for oral cavity. When used in less than 0.01% by weight it is impossible to uniformly emulsify the components, and containing more than 3.0% by weight may adversely affect the viscosity and usability of the composition.

Solvent as a component of the composition for oral cavity strengthening according to the present invention is composed of purified water or ethyl alcohol which is not toxic to the human body and can dissolve a water-soluble polymer, it can be used alone or in combination with ethyl alcohol.

As a constituent of the composition for oral cavity strengthening according to the present invention, the sweetener may be used at least one selected from the group consisting of sodium saccharin, aspartame, stevioside, xylitol, licoriceic acid, etc. But it is not limited thereto. Such sweetener is preferably used in an amount of 0.05 to 5% by weight based on the total weight of the composition for oral cavity.

Oral composition for strengthening teeth according to the present invention may further contain a flavoring agent in an amount of 0.001 to 1% by weight in addition to the essential ingredients as described above.

The composition for oral cavity strengthening according to the present invention may optionally contain an active ingredient effective for oral diseases in addition to the above components. As such components, but not limited to tartar deposition prevention components such as sodium pyrophosphate, potassium pyrophosphate, components such as glycerophosphate, calcium chloride, and the like.

Oral composition for reinforcing teeth according to the present invention is characterized in that it is used directly applied to the tooth surface using a tool selected from a brush, cotton swab or the like or attached to the teeth after containing the gel in the tray for teeth.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, the scope of the present invention is not limited thereto, and modifications commonly known in the art may be performed, and such modifications are also included in the scope of the present invention.

EXAMPLES AND COMPARATIVE EXAMPLES Preparation of Tooth Strengthening Gel and Toothpaste

As an example, according to the present invention, a tooth strengthening gel which was a fluorine coating agent having the composition of Table 1 was prepared, and a toothpaste having a composition of Table 2 was prepared as a comparative example. At this time, the concentration of fluorine in the product was prepared not to exceed 1000ppm each.

Composition of tooth strengthening gel division Ingredient Name Example 1 adhesive Polyvinyl alcohol 20 Active ingredient Sodium fluoride 0.22 corrector Citric acid 0.1 Emulsifier Polyoxyethylene (20) sorbitan stearate 0.7 Sweetener Saccharin Sodium 0.2 Pigment KFDA approved tar color Quantity antiseptic Methyl paraben 0.2 Spices Spices 0.5 solvent Purified water Quantity

Composition of toothpaste division Ingredient Name Comparative Example 1 abrasive Function 17 Active ingredient Sodium fluoride 0.22 Humectant Sorbitol solution 50 Thickener Carboxymethyl Cellulose Sodium 1.0 Foam Sodium Lauryl Sulfate 2.0 antiseptic Methylparaben 0.2 Spices Combination spices 1.0 Sweetener Zaccarin Sodium 0.2 pH regulator Sodium citrate 0.4 Active ingredient Tocopherol Acetate 0.2 Brightener Titanium dioxide 0.3 solvent Purified water Remainder

[Test Example 1] tooth surface fluorine adsorption confirmation experiment

The amount of fluorine adsorption on the surface of the tooth was confirmed after using the non-coating agent which is an example prepared by the above method and the toothpaste which is a comparative example. First, the bovine bovine was cut into a diamond saw, each about 4 mm wide, and then fixed with a acrylic resin. The fixed specimen was first polished using a 30 μm grade lapping disc, followed by secondary polishing in 9 μm steps. Ultrasonication was then performed to complete the final preparation. The final prepared four dental specimens were separated into Examples and Comparative Examples, respectively, and the element distribution on the surface of the specimen was primarily confirmed by SEM-EDS. For SEM, Hitachi's S-4300 was used. For EDS (Energy Disperse X-ray microanalysis), EDAX's EDAX HIT S-4300 was used. Table 3 shows the average value of the element distribution on the surface of the four bovine specimens before the reagent treatment, wt% means the weight ratio, at% means the ratio of the number of atoms, and K denotes the electron angle It means the electron was shot at the angle of K.

Element Distribution on the Surface of Loach Specimen Before Reagent Treatment element wt% at% C K 32.88 48.39 O K 30.58 33.79 F K 0.00 0.00 Na K 0.44 0.35 P K 11.97 6.83 Ca K 24.13 10.64 Total 100.00 100.00

Each treatment was performed using the fluorine coating agent of Example and the toothpaste of the comparative example, and the element distribution of the surface of the specimen was confirmed, respectively. In the case of the fluorine coating agent as an example, a small amount of the coating agent was applied to the ouch specimens by using a brush, and then left for 4 minutes, and then washed four times with water for 1 minute. In the case of the toothpaste of the comparative example, a total of 20 times was repeated by mixing 15 g of glycerine with 5 g of toothpaste, making a total of 20 g, and then brushing the specimen in a brushing machine for 10 minutes. After drying the specimens by the above method, the amount of element distribution on the surface of the specimen was confirmed by the SEM-EDS method, and the average values of the results are shown in Table 4 below. In the following wt% means a weight ratio, and at% means a ratio of the number of atoms.

Element distribution on the surface of decayed specimen after reagent treatment Element Example (wt%) Example (at%) Comparative Example (wt%) Comparative Example (at%) C K 43.81 54.64 31.49 42.11 O K 32.39 30.33 46.48 46.69 F K 13.82 10.90 0.87 0.74 NaK - - 2.11 1.48 MgK - - 0.91 0.60 SiK - - 1.21 0.69 P K 3.57 1.73 7.67 3.98 CaK 6.41 2.40 9.26 3.71 Total 100 100 100 100

As can be seen in Table 4, in the comparative example, the adsorption amount of the fluorine adsorption amount on the surface of the decay was less than 1% by weight, but the adsorption amount of the fluorine adsorption amount was 30% by weight or more, which is very excellent. I could confirm it.

Test Example 2 Tooth Surface Hardness Change Experiment

The final prepared four tooth specimens were separated into Examples (Example-1, Example-2) and Comparative Examples (Comparative Example-1, Comparative Example-2), respectively, and the primary surface hardness was measured. Surface hardness was measured by a digital display microhardness tester (model HVS-1000), and was performed in the following manner. First, the woofer specimen to be measured is placed on the top structure of the device, and a specific force between 150 and 200 KNS is pressed on the specimen to compress the diamond indentation formed on the surface of the specimen. The hardness of four points in one sample was measured, and the primary hardness measurement of the four samples is shown in Table 5 below.

Hardness of Loach Specimens Before Reagent Processing A B C D Average Example-1 30.6 20 26.3 30.9 27.0 Example-2 49.8 55.5 45.7 50.3 50.3 Comparative Example-1 28.6 29.4 34.5 37.6 32.5 Comparative Example-2 52.2 68.2 28.8 39.9 47.3

The change in hardness of the dental specimens was measured using the fluorine coating agent of Example and the toothpaste of Comparative Example, respectively. In the case of the fluorine coating agent as an example, a small amount of the coating agent was applied to the ouch specimens using a brush, and then left for 4 minutes, and then washed four times with water. This method is set to use about once a week once a month. In the case of the toothpaste of the comparative example, a total of 20 times was repeated by mixing 15 g of glycerine with 5 g of toothpaste, making a total of 20 g, and then brushing the specimen in a brushing machine for 10 minutes. This method is set to brush three times a day, three minutes, 30 days. At this time, the brushing condition was performed by setting the load of the brushing machine to take 400 g. The secondary hardness of the four specimens tested by the above method was measured by a digital display microhardness tester, and the measured values are shown in Table 6 below.

Hardness of Loach Specimen After Reagent Treatment A B C D Average Example-1 94.12 95.51 99.34 95.36 96.08 Example-2 153.36 201.69 175.68 182.15 178.22 Comparative Example-1 67.51 56.07 63.88 59.21 61.67 Comparative Example-2 60.68 71.16 73.57 66.52 67.98

As can be seen in Table 6, in the comparative example was the average hardness of the decay specimens 61.67 and 67.98, in the case of the example, the hardness of the tooth decay specimens 96.08 and 178.22 was much higher. Through this, it can be seen that the fluorine coating agent as an example is much superior in strengthening the hardness of the tooth compared to the comparative toothpaste.

Claims (6)

At least one tooth strengthening component selected from the group consisting of sodium fluoride, sodium monofluorophosphate, tin fluoride and mixtures thereof; And at least one water-soluble pressure sensitive adhesive selected from the group consisting of gelatin, polyacrylic acid, polyvinyl alcohol, xanthan gum, galang gum, sodium alginate, polyvinylpyrrolidone, polyvinylformamide, carboxymethylcellulose and carboxypolymethylene. Oral composition for tooth strengthening. According to claim 1, wherein the composition for oral cavity is composed of sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, sodium citrate, sodium monophosphate, sodium diphosphate, sodium triphosphate, sodium pyrophosphate and sodium metaphosphate Oral composition for strengthening teeth, characterized in that it further comprises at least one neutralizer selected from. The tooth composition of claim 1, wherein the oral composition further comprises at least one emulsifier selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyglyceryl fatty acids, and fatty acid sugar esters. Strengthening oral composition. The method according to any one of claims 1 to 3, wherein the tooth strengthening component is 100-1000 ppm based on the total weight of the composition; And the water-soluble adhesive is 5.0 to 50.0% by weight based on the total weight of the composition. The oral composition according to any one of claims 1 to 3, wherein the composition for oral cavity is in a gel state. delete