KR101883753B1 - Composition for filling in dental tubles and Sprayer for the same - Google Patents

Abstract

The present invention relates to a composition for preventing syringance including fine powder and a sprayer for preventing syringe. The method according to the present invention is useful for alleviating and treating diseases caused by exposure of tooth dentin such as cervical erosion and dental hypersensitivity since fine powder for tooth dentin supplementation can effectively adsorb to tooth dentin to close dentinal tubules.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001]

The present invention relates to a composition for preventing syringance including fine powder and a sprayer for preventing syringe.

Dental tissues are composed of enamel, cement and dentin. The outer part of the exposed teeth is covered with enamel, and the outer part of the tooth root located in the alveolar bone is covered with cementite, and dentin is present inside these teeth. In the dentin, a fine tube called dental tubules is distributed throughout the dentin.

Dental hypersensitivity refers to the symptoms of tooth whorish when eating fresh fruit or drinking cold water. When the tooth is broken due to erroneous brushing, or when the gum is contracted by gum disease, the dentinal tubules protected by the gum are exposed .

These dental hypersensitivity treatments include dentinal tubule sealing and dimensional neuron desensitization. Dentin tubule sealing is a treatment for filling the exposed dentinal tubules with resin and the like, and the dental neuron desensitization method is a treatment for increasing the content of potassium ions and preventing the nerve from feeling sickness. On the other hand, toothpastes that can relieve and treat dental hypersensitivity have been developed and sold without being subjected to the above-mentioned professional treatment by visiting a dentist. A typical example is Sensodyne manufactured by GloxoSmithKlein. However, as described above, materials that can alleviate and cure the tooth surface are sold as toothpaste or mouthwash. As a result, they are diluted very quickly in the course of brushing, and they are washed away while rinsing the mouth. There is a problem that it can not be done. In addition, when used as a toothpaste or mouthwash, there is also a problem that it is not possible to accurately treat a tooth in teeth showing hypersensitivity to teeth. Korean Patent No. 10-0395974 or No. 10-0806050 discloses a dentifrice composition for suppressing the phenomenon of syringing. However, as in the case of the present invention, a substance capable of inhibiting the syringe phenomenon may be used in the form of an aerosol or spray There has been no disclosure of an invention for direct injection into a tooth.

As a result, the present inventors have made intensive efforts to solve the above-mentioned problems, and as a result, it has been confirmed that effective and intensive treatment is possible in the case of spraying the fine powder for tooth dentifrice supplementation in the form of an aerosol or a spray to the tooth, .

Korean Patent No. 10-0395974 Korean Patent No. 10-0806050

An object of the present invention is to provide a composition for preventing syringes and an injector for preventing syringes.

In order to attain the above object, the present invention provides a spray formulation composition for preventing syringe containing fine powder.

In addition, the present invention relates to an injector for preventing syringing by spraying contents to a syringe portion, the injector comprising: a spray formulation composition for preventing syringe; And a dispersant for receiving and spraying the composition, wherein the disperser comprises a body for containing the composition.

The use of the composition or the injector according to the present invention allows the dentin complementary micropowder to be effectively adsorbed on the dentin so as to close the dentine tubule, thereby alleviating and preventing the syringe due to exposure of the dentine dentin such as cervical abrasion and tooth hypersensitivity .

Fig. 1 is a sprayer for preventing syringe used in the present invention.
FIG. 2 shows the result of measurement of the degree of closing of ivory tubules according to the formulation type of fine powder.

Dentin is a hard, white, yellowish tissue that forms the majority of dental tissue, and dentin tubules are distributed throughout the dentin. The cell protrusions in the dental pulp are distributed as enamel from the dimension to constitute the dental tubules, and the space between the dental tubules and the cell protrusions is filled with the dentin fluid.

Dentin hypersensitivity refers to a case in which the external stimulus such as a temperature stimulus causes a symptom of ache in a tooth, or a case in which the symptom persists for a long time and develops into pain. Tooth cervical erosion refers to a state in which the gum of the root portion is lowered and the exposed surface of the tooth is worn, and the dentin in the cement is exposed when the gum is lowered. Dentin hyperesthesia refers to a phenomenon that becomes sensitive to various stimuli when dentin is exposed due to wear and tear of enamel and cementitious materials, and retraction of periodontal tissue. The cause of such symptoms is that the entrance of the ivory tubule is exposed. When the enamel or cementum is destroyed and the entrance of the dentinal tubule is exposed to the outside, the stimulation is transmitted to the dimension by the cell protrusion, nerve and dentin liquid of the dentinal tubule, and the pain is felt.

The present invention, in one aspect, relates to a composition for preventing syringes, the composition being directed to a spray formulation composition for preventing syringes comprising a fine powder.

In addition, in the injection formulation composition for prevention of sickness, which is one aspect of the present invention, the spray formulation composition may contain fine powder adsorbed on the surface of the tooth dentin as an active ingredient.

In one aspect of the present invention, the fine powder may be a powder having a size of 50 nm to 10 탆, and may be an injection formulation composition for preventing syringes. When the size of the fine powder is less than 50 nm, the size of the powder is small, and thus there is a limit in closing the iv tubule. When the size of the fine powder is more than 10 μm, the iv tubule having a size of 1 to 3 μm can not be effectively closed There is a limit. In view of this, it is preferable that the fine powder of the anti-calming spray composition of the present invention includes a size of 20 nm to 20 μm, 200 nm to 20 μm, 20 nm to 2 μm, or 200 nm to 2 μm.

In one aspect of the present invention, the fine powder may be a mineral or metal salt, spray inhibiting composition for inhibiting syringes. The fine powder may be selected from the group consisting of calcium carbonate, heavy calcium carbonate, light calcium carbonate, calcium silicate, calcium lactate, calcium phosphate, tricalcium phosphate, calcium hydrogenphosphate hydrate, hydroxyapatite, silicon dioxide, strontium chloride, strontium acetate, Potassium nitrate, and the like, but there is no limitation as long as it is a substance capable of closing the entrance of the ivory tubule.

In one aspect of the invention, the spray formulation may be an aerosol or spray formulation, a spray inhibiting injection formulation, and the spray formulation may be an aerosol, spray inhibiting injection formulation. The container comprising the aerosol or spray form may comprise a fine powder for tooth dentin supplementation such as calcium carbonate, heavy calcium carbonate, light calcium carbonate, calcium silicate, calcium lactate, calcium phosphate, tricalcium phosphate, calcium hydrogen phosphate hydrate, Is a spray apparatus made of other materials known to be safe for storing one or more materials in the group consisting of apatite, silicon dioxide, strontium chloride, strontium acetate, potassium chloride and potassium nitrate, and compressed gas aerosol spray technology. In the present invention, an example of a container including an aerosol or a spray form is shown in FIG. 1, but there is no limitation as long as the container includes an aerosol or a spray form conventionally used in the art.

When tooth powder is applied to a tooth using a dentifrice or mouthwash, the fine powder is diluted in the process of brushing, and the mouth is rinsed and rinsed together, so that the dentinal tubule can not be effectively closed. On the other hand, in the case of the present invention in which the fine powder for supplementing tooth dentin is sprayed on the tooth in the form of an aerosol or spray, the fine powder can be intensively sprayed on the tooth part of the tooth and the fine powder is effectively adsorbed on the surface of the dentin , Effectively closing the dentinal tubules. In addition, unlike toothpaste formulations and mouth wash, since it can be used by spraying directly onto teeth, there is no inconvenience of weaving toothpaste and brushing, and convenience of use is also improved.

According to another aspect of the present invention, there is provided an injector for preventing syringing by spraying the contents to a syringe portion from another viewpoint, the injector comprising: a spray formulation composition for preventing syringe; And a distributor for receiving and spraying the composition, wherein the distributor comprises a body for receiving the composition, the sprayer for preventing syringes is shown in FIG.

According to an aspect of the present invention, there is provided a spray preventing injector, wherein the body is connected to a needle for spraying the composition.

In one aspect of the present invention, the needle 20 may be a syringe-preventing injector 1, which is a folding needle including a folding unit 100 capable of folding and unfolding. FIG. 1 (a) shows a spray needle 20 for spraying fine powder onto a tooth. FIG. 1 (b) shows a state in which the spray needle 20 is bent It is. In the present invention, the needle 20 attached to the body 10 including the fine powder is thin and thin, so that it is possible to spray the fine powder effectively and intensively at a desired position, The folding and unfolding of the film is excellent in storage stability.

In one aspect of the present invention, the injection formulation composition for preventing sickness may be a spray inhibitor for preventing sickness, which comprises fine powder adsorbed on the surface of tooth dentin as an active ingredient. In addition, the fine powder may be a powder having a size of 50 nm to 10 mu m, or a sprayer for preventing syringes. When the size of the fine powder is less than 50 nm, the size of the powder is small, and thus there is a limit in closing the iv tubule. When the size of the fine powder is more than 10 μm, the iv tubule having a size of 1 to 3 μm can not be effectively closed There is a limit. In view of this, it is preferable that the fine powder of the anti-calming spray composition of the present invention includes a size of 20 nm to 20 μm, 200 nm to 20 μm, 20 nm to 2 μm, or 200 nm to 2 μm.

In one aspect of the present invention, the fine powder may be a mineral or metal salt spray preventing injector, and the fine powder may be calcium carbonate, heavy calcium carbonate, light calcium carbonate, calcium silicate, calcium lactate, calcium phosphate, phosphoric acid At least one selected from the group consisting of calcium phosphate, calcium hydrogenphosphate hydrate, hydroxyapatite, silicon dioxide, strontium chloride, strontium acetate, potassium chloride and potassium nitrate.

In one aspect of the present invention, the injector may be an aerosol injector or a spray injector, a syringe-preventing injector, and the injector may be an aerosol injector, a syringe-preventing injector.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for illustrating the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

[ Example  1] To measure the degree of occlusion of the dentinal tubules according to the size of the fine powder when spraying the fine powder adsorbed on the dentin surface with an aerosol formulation.

After extracting a human tooth, cut it in half in the vertical direction. After dentin-exposed tooth specimens were sprayed three times with aerosol formulations of the materials of Experimental Examples 1 to 5 and Comparative Example 2 shown in Table 1, they were stored in artificial saliva for 30 minutes. Then, after drying for 24 hours in an oven at 60 ° C, SEM (Scanning Electron Microscope) is measured. The area of the perforation of the perforation was measured using an image analyzer (Image-Pro PLUS, v 6.0, Media Cybernetics, Silver Spring, MD, USA) and the area of the perforated dentinal tubules Respectively.

Component (% by weight) Experimental Example 1 Experimental Example 2 Experimental Example 3 Experimental Example 4 Experimental Example 5 Comparative Example 1 Comparative Example 2 Purified water Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Carboxymethylcellulose sodium One One One One One One Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 Sodium saccharin 0.20 0.20 0.20 0.20 0.20 0.20 Sorbitol solution 26.00 26.00 26.00 26.00 26.00 26.00 Hydroxy apatite 20 um 20 Hydroxy apatite 2um 20 Hydroxyapatite 200 nm 20 Hydroxy apatite 20 nm 20 Light calcium carbonate 200 nm 20 Injector (LPG) 5 5 5 5 5 5 Chelating agent Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount antiseptic Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount incense Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Area of perforated ducts
(Unit: um ² , average of 20) 4.02 1.28 0.81 3.65 1.07 5.45 4.97

As a result of the above-mentioned experiment, it was observed that the dentinal tubules which were drilled in Experimental Example 1-5 containing fine powder were effectively closed.

In addition, it was confirmed that Comparative Example 2 had no effect of closing the iv tubule.

[ Example  2] To determine the degree of occlusion of dentinal tubules according to the size of fine powder when spraying fine powder adsorbed on tooth dentin surface with spray formulations.

After extracting a human tooth, cut it in half in the vertical direction. The dentin-exposed tooth specimens were sprayed three times with the spray formulations of the materials of Experimental Examples 1 to 5 and Comparative Example 2 shown in Table 2, and then kept in the artificial saliva for 30 minutes. Then, after drying for 24 hours in an oven at 60 ° C, SEM (Scanning Electron Microscope) is measured. The area of the perforation was measured using an image analyzer (Image-Pro PLUS, v 6.0, Media Cybernetics, Silver Spring, MD, USA) and the area of the perforated dentinal tubules Respectively.

Component (% by weight) Experimental Example 6 Experimental Example 7 Experimental Example 8 Experimental Example 9 Experimental Example 10 Comparative Example 3 Comparative Example 4 D.I.Water Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Xylitol 5.00 5.00 5.00 5.00 5.00 5.00 Emalex HC-60 4.40 4.40 4.40 4.40 4.40 4.40 Glycerin 3.00 3.00 3.00 3.00 3.00 3.00 Hydroxy apatite 20 um 20 Hydroxy apatite 2um 20 Hydroxyapatite 200 nm 20 Hydroxy apatite 20 nm 20 Light calcium carbonate 200 nm 20 antiseptic Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount incense Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Area of perforated ducts
(Unit: um ² , average of 20) 4.23 1.28 1.11 3.91 1.40 5.45 5.21

As a result of the above-mentioned experiment, it was observed that the dentinal tubules which were drilled in Experimental Example 6-10 containing fine powder were effectively closed.

In addition, in Comparative Example 4, it was confirmed that there was no effect of closing the iv tubule.

[ Example  3] Measurement of the degree of occlusion of dental caries according to the formulation type of fine powder.

After extracting a human tooth, cut it in half in the vertical direction. After dentin-exposed tooth specimens were sprayed three times with toothpaste formulation (Experimental Example 11), mouse wash formulation (Experimental Example 12) and aerosol formulation (Experimental Example 13) each containing 2 um of hydroxyapatite, Store for 30 minutes. The toothpaste formulation is shown in Table 3 below, and the mouse wash formulation was used as shown in Table 4 below. In addition, the aerosol formulation was used as in Experimental Example 2 of Example 1. Table 3 shows the toothpaste formulation (Experimental Example 11), and Table 4 shows the mouse wash formulation (Experimental Example 12).

ingredient weight% Carboxymethylcellulose sodium 1.00 Spices Suitable amount Methyl paraben 0.15 Sodium fluoride 0.22 Sodium saccharin 0.20 Sorbitol solution 26.00 Hydroxy apatite 2um 20.00 Sodium lauryl sulfate 2.00 antiseptic Suitable amount Purified water Suitable amount

ingredient weight% Purified water Suitable amount Sodium fluoride 0.03 Sodium saccharin 0.01 antiseptic Suitable amount Sorbitol 10.00 incense Suitable amount EMALEX HC-60 0.50 Hydroxy apatite 2um 20.00

Then, after drying for 24 hours in an oven at 60 ° C, SEM (Scanning Electron Microscope) is measured. The area of the perforation of the perforation was measured using an image analyzer (Image-Pro PLUS, v 6.0, Media Cybernetics, Silver Spring, MD, USA) and the area of the perforated dentinal tubules Respectively.

As a result of the above experiment (FIG. 2), it was confirmed that the effect of closing the dental tubules was most excellent when the fine powder was sprayed into the aerosol formulation.

While the present invention has been particularly shown and described with reference to specific embodiments thereof, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this invention. something to do. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (16)

A spray formulation composition for preventing syringes,
Wherein the spray formulation composition comprises a fine powder adsorbed on a tooth dentin surface,
The fine powder has a size of 200 nm to 2 占 퐉,
Wherein the fine powder is at least one selected from hydroxyapatite and light calcium carbonate. delete delete delete delete 2. The spray formulation of claim 1, wherein the spray formulation is an aerosol or spray formulation. 7. The spray formulation of claim 6, wherein the spray formulation is an aerosol. A sprayer for preventing syringe by spraying the contents to the syringe,
The injector
A spray formulation composition for preventing sickening of claim 1; And
A distributor for receiving and dispensing the composition,
Wherein the dispenser comprises a body for containing the composition. The sprayer of claim 8, wherein the body is connected to a needle for spraying the composition. 10. The method of claim 9,
Wherein the needle is a folding needle including a folding portion capable of folding and unfolding. delete delete delete delete 11. An injector according to any one of claims 8 to 10, wherein the injector is an aerosol injector or a spray injector. 16. The injector according to claim 15, wherein the injector is an aerosol injector.

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