KR20130057632A - Cosmetic composition for skin cell activation - Google Patents

Abstract

PURPOSE: A cosmetic composition containing oxygen and sulfates for promoting skin cell activation and skin vitality is provided to improve skin moisturization, skin whitening, elasticity, and anti-wrinkling and to treat skin troubles. CONSTITUTION: A cosmetic composition contains 0.1-80 wt% of oxygen in oxygenized water and 0.1-10 wt% of sulfates in mineral water, as active ingredients. The sulfates are selected from a group consisting of magnesium sulfate, zinc sulfate, and manganese sulfate. The composition further contains 0.001-2 wt% of a yeast extract. The dissolved oxygen of the oxygenized water is 20-200 ppm.

Description

Cosmetic composition for enhancing skin vitality {Cosmetic composition for skin cell activation}

The present invention relates to a cosmetic composition for enhancing skin vitality, and more particularly to a cosmetic composition for enhancing skin vitality by promoting the activation of skin cells by containing oxygen and sulfates as an active ingredient.

More specifically, the present invention relates to a cosmetic composition for enhancing skin vitality by promoting skin cell activation by containing at least one of oxygen, magnesium sulfate, zinc sulfate and manganese sulfate as active ingredients. In another aspect, the present invention relates to a cosmetic composition for enhancing skin vitality, further comprising a yeast soluble extract as an active ingredient, having a synergistic effect on skin cell activation.

Skin is the body's primary protective barrier that protects organs from changes in temperature and humidity, ultraviolet rays and pollutants. However, with age, the secretion of various hormones that regulate metabolism internally decreases, and the function of immune cells and the activity of cells decreases. Externally, the ultraviolet rays increase in the sun's rays due to the destruction of the ozone layer, and the excessive physical and chemical irritation and stress caused by the increase of free radicals and active harmful oxygen as environmental pollution becomes more severe are normal functions of the skin. Decreases, promotes the production of blemishes, freckles, etc. due to melanin deposition and skin aging to damage the skin.

In order to prevent skin aging and damage caused by these internal and external factors to maintain a healthier and more beautiful skin, various bioactive substances are used in addition to cosmetics to maintain the unique function of the skin and activate skin cells to metabolize the skin. Efforts are being made to promote greater vitality by promoting public relations.

While breathing through the skin during human breathing is only about 0.6 ~ 1% of the total breathing volume, oxygen through skin breathing is used in all skin cells. In addition, through skin breathing, very important activities such as heat dissipation and toxin release are performed. However, as the body ages, the partial pressure of oxygen in the body is remarkably decreased, and thus, the activity and regeneration of skin cells are reduced, which is the main culprit for skin aging. Therefore, there is a need to develop a substance that prevents aging by enhancing the activity of the skin and improves skin vitality.

Korean Patent Application No. 2007-0068739

Accordingly, the present inventors searched various bioactive substances to find a substance that is safe for the skin and promotes skin cell activation to promote skin vitality, and thus, oxygen and minerals, more specifically magnesium sulfate, zinc sulfate, and manga. When sulfates such as nissulfate are contained as an active ingredient, it has been found to have an effect of promoting skin cell activation to enhance skin vitality. It has also been found to have a synergistic effect of this effect when it further contains yeast soluble extract as an active ingredient.

Therefore, the object of the present invention is oxygen; And one or more of sulfates of magnesium sulfate, zinc sulfate, and manganese sulfate; It is to provide a skin cosmetic composition for enhancing skin cell activation having no side effects of skin irritation, and is stable in formulation, having excellent skin cell activation effect. Another object of the present invention is oxygen; Yeast soluble extracts; And one or more of sulfates of magnesium sulfate, zinc sulfate, and manganese sulfate; It is to provide a skin cosmetic composition for enhancing skin cell activation having no side effects of skin irritation, and is stable in formulation, having excellent skin cell activation effect.

In order to achieve the above object, the present invention is oxygen; And sulfates of magnesium sulfate, zinc sulfate and manganese sulfate; It contains as an active ingredient to provide a cosmetic for enhancing skin vitality to promote skin cell activation.

In addition, the present invention is oxygen; Yeast soluble extracts; And one or more of sulfates of magnesium sulfate, zinc sulfate, and manganese sulfate; It contains as an active ingredient to provide a cosmetic for enhancing skin vitality to promote skin cell activation.

The cosmetic composition provided by the present invention may provide an effect of enhancing skin cell activation to enhance skin vitality, and thus may have an effect of improving skin moisturizing, skin whitening, skin elasticity, skin wrinkle improvement, and trouble. . Therefore, the active ingredient may provide a skin vitality enhancing cosmetic composition having an effect such as promoting skin cell energy metabolism.

Oxygen water is water containing dissolved oxygen higher than normal water by dissolving dissolved oxygen dissolved in water to super saturation concentration. By supplying oxygen water containing high concentration of oxygen directly on the skin, it promotes the respiration of skin cells and activates the cells, delays the maintenance of hydration and aging, and promotes skin turnover to release the melanin produced from the skin. It can promote whitening effect.

The oxygen contained in the cosmetic composition of the present invention is preferably in the form of oxygen water dissolved in water, the oxygen water may be contained in a ratio of 0.1 to 80% by weight relative to the total weight of the composition. When the oxygen water is less than 0.1% by weight relative to the total weight of the composition, the moisturizing effect and the active effect of the skin cells are insignificant, and when the amount exceeds 80% by weight, the effect is no longer increased significantly, and the efficiency of the raw material is decreased, and the feeling of use of the formulation This is because the deterioration lowers the value as a cosmetic.

Mineral water is water that contains higher specific minerals than ordinary water. In particular, mineral water such as magnesium sulfate, zinc sulfate, and manganese sulfate in mineral water is an indispensable material for maintaining homeostasis. The direction and amount of water to be transported to is determined by the concentration of minerals, which can lead to the accumulation or dehydration of body fluids if the minerals are not balanced. As such, minerals, although absorbed into the human body, are essential substances that play a role in coordinating cell activity.

The sulfates contained in the cosmetic composition of the present invention may preferably use one or more selected from the group consisting of magnesium sulfate (MgSO ₄ ), zinc sulfate (ZnSO ₄ ), and manganese sulfate (MnSO ₄ ). It doesn't happen.

The sulfates are preferably in the form of mineral water dissolved in water. The mineral water is more preferably contained in a ratio of 0.01 to 10% by weight based on the total weight of the composition, when the mineral water is less than 0.01% by weight relative to the total weight of the composition, it is difficult to expect the effect of promoting skin cell activity, 10.0% by weight If the percentage is exceeded, the effect is no longer greatly increased, which reduces the efficiency of the raw material and may cause skin irritation. In addition, the mineral water preferably contains 5% by weight of the sulfates relative to the total weight of the mineral water, more preferably the mineral water is 5% magnesium sulfate (MgSO ₄ ) mineral water, 5% zinc sulfate (ZnSO ₄ ) mineral water and 5% manganese sulfate (MnSO ₄ ) mineral water.

Yeast soluble extract contained in the cosmetic composition of the present invention is an extract obtained by fermenting Saccharomyces cerevisiae (Baker's Yeast), the yeast soluble extract is preferably contained in a ratio of 0.001 to 2% by weight based on the total weight of the composition, the mineral If the number is less than 0.001% by weight of the total weight of the composition, it is difficult to expect the effect of promoting skin cell activity, and if the amount exceeds 2% by weight, the effect is no longer increased significantly, resulting in a decrease in the efficiency of the raw material and causing skin irritation. Can be.

The oxygen water contained in the cosmetic composition of the present invention is water containing oxygen higher than ordinary water by dissolving dissolved oxygen dissolved in water to a supersaturation concentration. By supplying the high concentration of oxygen-containing water directly on the skin, it promotes the respiration of skin cells and activates the cells, thereby preventing skin problems, promoting blood circulation, and promoting skin cell energy metabolism.

The oxygen water contained in the cosmetic composition of the present invention may contain 20 to 200 ppm of dissolved oxygen. The oxygen water may increase the dissolved oxygen amount by injecting oxygen repeatedly for 10 to 120 minutes at a pressure of 1 to 10 kg / cm ² with an oxygen injector such as air stone to the distilled water. The preparation of the oxygen water is preferably prepared at a low temperature in order to increase the solubility of the gas, but is not limited thereto.

The method for producing the sulfate mineral water contained in the cosmetic composition of the present invention is not particularly limited, and is produced and used by a conventional method.

The yeast dissolution extract manufacturing method contained in the chemical composition of this invention is not specifically limited, It manufactures and uses by a conventional method.

The composition of the present invention may provide an effect of enhancing skin vitality and thereby may have an effect of improving skin moisturizing, skin whitening, skin elasticity, skin wrinkle improvement and trouble.

Cosmetic compositions according to the invention may be formulated containing a cosmetically or dermatologically acceptable medium or base. These are all formulations suitable for skin, for example emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) and non-obtained by dispersing an oil phase in solutions, gels, solids, pasty anhydrous products, aqueous phases. It may be provided in the form of an ionic vesicle dispersant or in the form of a skin, lotion, cream, pack, gel, makeup base, foundation, powder, ointment, spray or concealed stick. These compositions may be prepared according to conventional methods in the art. The composition according to the invention may also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

The cosmetic composition according to the present invention is a fatty substance, an organic solvent, a dissolving agent, a thickening agent, a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, a surfactant, water, an ionic or nonionic. Such as type emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredients commonly used in cosmetics. It may contain adjuvants conventionally used in the cosmetic or dermatology field. Such adjuvants are introduced in amounts commonly used in the cosmetics or dermatological fields.

Hereinafter, the present invention will be described in more detail through reference examples, examples, and experimental examples, but the scope of the present invention is not necessarily limited to these examples.

Reference Example 1 Preparation of Oxygen Water

20 kg of distilled water is first injected with ultra high-purity oxygen at a pressure of 1 kg / cm ² for 20 minutes using Air Stone (Daekwang, DK-6000), and then cooled to 15 ° C with cooling water and 2 kg / A ^second injection was performed at a pressure of cm ² for 10 minutes, and cooled to 15 ° C., followed by a third injection of ultrapure oxygen at a pressure of 3 kg / cm ² for 10 minutes, and then sealed to prepare an extract that increased dissolved oxygen. As a result of measuring the oxygen dissolved concentration of the extract with a dissolved oxygen measuring instrument (HI964400, HANNA instrument, ITALY), it was confirmed that oxygen was dissolved at a concentration of 33 ppm.

[Reference Examples 2-4] Preparation of Mineral Water

Magnesite, magnetized ball, zeolite, blood flow promoting ball, tourmaline, germanium-filled mineral water production filter is prepared (Bioland) and then put into the reactor, and water is filled by 2/3 of the reactor, the mineral The reactor was shaken several times to allow sufficient interaction between the water generation filter and water, and magnesium sulfate mineral water (Reference Example 2) and zinc sulfate containing 5% of magnesium sulfate, zinc sulfate and manganese sulfate, respectively, based on the total weight of mineral water. Mineral water (Reference Example 3) and manganese sulfate mineral water (Reference Example 4) were prepared.

 Reference Example 5 Preparation of Saccharomyces Lysate Extract (Arch, USA)

Beer yeast (Saccharomyces cerevisiae) was obtained by fermentation for 5 hours while mixing at 20-25 ° C. under light-blocking conditions with aminopeptidase, a kind of proteolytic enzyme.

[ Manufacturing example  1] oxygen and Sulfates , Production of composition containing yeast soluble extract

Examples 1 to 3, oxygen and magnesium sulfate and zinc sulfate, which are compositions containing one of oxygen and magnesium sulfate, zinc sulfate and manganese sulfate in the compositions shown in Table 1 using the Reference Examples 1 to 5 Example 4 which is a composition containing, Example 5 which is a composition containing oxygen and magnesium sulfate, zinc sulfate and manganese sulfate, Example 6 which contains oxygen, magnesium sulfate and yeast soluble extract, and oxygen, magnesium sulfate, zinc Comparative Example 1, a composition containing neither sulfate nor manganese sulfate, Comparative Example 2 containing only oxygen, Comparative Example 3 containing only magnesium sulfate, zinc sulfate, and manganese sulfate, and Comparative Example 4 containing only a yeast fermented extract Prepared. Examples 1 to 6 and Comparative Examples 1 to 4 were all prepared by O / W formulation, and the unit of the content shown in Table 1 is wt%.

division Raw material name Example 1 Example
2 Example
3 Example
4 Example
5 Example
6 Comparative Example
One Comparative Example
2 Comparative Example
3 Comparative Example 4 Paid
part Polysorbate 60 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Glyceryl stearate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Fiji-100 Stearate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Meadowfoam seed oil 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Cyclomethicone 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Dimethicone 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Behenyl alcohol 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Cetearyl alcohol 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 7-ethylhexanoate 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 10.0 antiseptic Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Awards
part Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 Disodium ID 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 glycerin 10.0 10.0 10.0 10 10 10 10 10 10 10 Other thickeners, neutralizers Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Oxygen water
(Reference Example 1) 1.0 1.0 1.0 1.0 1.0 1.0 - 3.0 - - Magnesium sulfate mineral water
(Reference Example 2) 1.0 - - 1.0 1.0 1.0 - - 0.75 - Zinc Sulfate Mineral Water
(Reference Example 3) - 1.0 - 1.0 1.0 - - - 0.75 - Manganese Sulfate Mineral Water
(Reference Example 4) - - 1.0 - 1.0 - - - 0.75 -  Saccharomyces Lysate Extract - - - - - 0.1 - - 0.75 3.0

<Manufacturing Method>

The oil phase parts were dissolved by heating to 70 ° C. in a separate container as the contents shown in Table 1, and then dispersed using a homogenizer. The aqueous part was dissolved by heating at 70 ° C., and then the oil phase part was slowly added to the aqueous part to emulsify at 70 ° C. Finally, the composition was filled into an airtight container and cooled to room temperature using a cooler.

[ Test Example  1] skin vitality

BMI [Body Mass Index, weight (kg) / height (m) ² ] was divided into 10 groups of 20 female subjects of 19-62 years of age 21-27 with 20 groups of Examples 1-5 and Comparative Examples 1-3. The composition was used with a massage after a shower once a day for 12 weeks, and compared with before and after 12 weeks of use was determined whether the effect. Evaluation items are shown in Table 2 below the number of subjects who responded to the questionnaire about skin cell activation and skin vitality.

Unit (person) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Skin Cell Activation 15 13 14 16 18 19 0 2 One 3 Skin Vitality Enhancement 14 16 13 17 18 20 One 3 2 One

As shown in the results of Table 2, in the evaluation of the feeling according to the user, the majority of the respondents used Examples 1 to 3, which are compositions containing one of oxygen water, magnesium sulfate, zinc sulfate and manganese sulfate mineral water for 12 weeks. After that, they responded that they felt skin cell activation (15, 13, 14) and skin vitality (14, 16, 13) and oxygen and magnesium sulfate and zinc sulfate in Example 4 and oxygen. Water and magnesium sulfate, zinc sulfate. After using Example 5, which is a composition containing all manganese sulfate, for 12 weeks, he responded that he felt skin cell activation (16, 18) and skin vitality (17, 18). In addition, after using Example 6, which is a composition containing oxygen water, magnesium sulfate, zinc sulfate, manganese sulfate, and yeast soluble extract for 12 weeks, skin cell activation (19 people) and skin vitality improvement (20 people) It was. On the contrary, in Comparative Examples 1 to 4, it was confirmed that the skin cell activation and skin vitality enhancing effects were hardly felt.

[ Test Example  2] cell energy activity enhancing effect

This experiment was performed using the samples obtained in Reference Examples 1 to 5, but the experiment proceeded as follows. First, human normal fibroblasts (ATCC, Dermal Fibroblasts) were inoculated into 1 × 10 ⁶ cells in each well of a 12-well microplate (Nunc, Denmark), and in DMEM medium (Sigma, USA) for 24 hours at 37 ° C. Incubated for 2 hours. Subsequently, one of Reference Examples 1 and 2 to 4 was mixed with distilled water at a 10% ratio so that the final concentration of oxygen was 3.3 ppm, magnesium sulfate, zinc sulfate, and manganese sulfate so that the final concentration was 0.5%. (Examples 7 to 9) and Reference Examples 1 to 3 were each mixed with purified water at a ratio of 10% to prepare a final concentration of oxygen of 3.3 ppm, magnesium sulfate, and zinc sulfate of 0.5%, respectively ( Example 10), Reference Examples 1 to 4 were each mixed with purified water at a ratio of 10% to prepare a final concentration of oxygen of 3.3 ppm, magnesium sulfate, zinc sulfate, and manganese sulfate at 0.5%. (Example 11). In addition, Reference Examples 1 to 4 were each mixed with purified water at a ratio of 10%, and the final concentration was 3.3 ppm of oxygen, 0.5% of each sulfates, and yeast dissolved extracts were also mixed with purified water to prepare a final concentration of 0.5% (Example 12).

In addition, Comparative Example 6 was prepared by mixing Reference Example 1 with purified water at a ratio of 10% and Comparative Example 6 by mixing Reference Examples 2 to 4 with purified water at a ratio of 10%, and Reference Example 5 at a ratio of 0.5%. Comparative Example 7 was prepared by mixing with purified water.

Experiments in which Examples 7 to 12 and Comparative Examples 5 to 7 were replaced with DMEM medium without serum, and the control group replaced with DMEM medium without serum for each sample were further incubated for 48 hours. After culturing, cells were obtained from each well, and then the degree of energy activity in each cell was measured using a cell energy analysis kit (ATP assay kit, Amersham, United States of America) to determine the activity of the cells of the sample in which the Examples and Comparative Examples were not used. As a control, the activity increase rate of the cells of the sample containing the example and the comparative example was calculated, and the energy activity promoting effect of each extract is shown in Table 3.

Test substance Skin Cell Energy Activity Effect (%) Control group 0 Example 7
(Oxygen water, magnesium sulfate mineral water) 69.5 Example 8
(Oxygen water, zinc sulfate mineral water) 68.7 Example 9
(Oxygen water, manganese sulfate mineral water) 64.3 Example 10
(Oxygen water, magnesium sulfate, zinc sulfate mineral water) 75.9 Example 11
(Oxygen water, magnesium sulfate, zinc sulfate, manganese sulfate mineral water) 89.6 Example 12
(Oxygen water, magnesium sulfate, zinc sulfate, manganese sulfate mineral water, yeast dissolution extract) 95.8 Comparative Example 5
(Oxygen) 20.1 Comparative Example 6
(Magnesium sulfate, zinc sulfate, manganese sulfate mineral water) 15.6 Comparative Example 7
(Yeast Dissolution Extract) 17.3

In the results of Table 3, the compositions of Examples 7 to 12 according to the present invention can be seen that the skin cell energy activity effect is excellent, a significant increase compared to Comparative Examples 5 to 7 using only oxygen water, sulfates, yeast soluble extract, respectively It can be seen that it has an effect.

Claims (9)

Cosmetic composition containing oxygen and sulfates as an active ingredient. The cosmetic composition according to claim 1, wherein the sulfate is at least one selected from the group consisting of magnesium sulfate, zinc sulfate and manganese sulfate. The method according to claim 1 or 2, wherein the oxygen is contained in an amount of 0.1 to 80% by weight as oxygen water, and the sulfates are contained in an amount of 0.1 to 10% by weight as mineral water dissolved in water. Cosmetic composition. The cosmetic composition according to claim 1 or 2, wherein the composition further comprises a yeast soluble extract. The cosmetic composition according to claim 4, wherein the yeast soluble extract is contained in an amount of 0.001 to 2% by weight based on the total weight of the composition. The cosmetic composition according to claim 3, wherein the oxygen water has a dissolved oxygen amount of 20 to 200 ppm. 4. The cosmetic composition according to claim 3, wherein the mineral water contains 5% by weight of the sulfates based on the total weight of the mineral water. According to claim 1 or 2, wherein the composition is a cosmetic composition, characterized in that for promoting the skin vitality to promote skin cell activation. According to claim 3, wherein the composition is a cosmetic composition, characterized in that for promoting skin vitality promoting skin cell activation.