KR20120131781A - Prefilled syringe filling machine and prefilled syringe filling method - Google Patents

Abstract

PURPOSE: An apparatus and a method for filling a syringe are provided to safely and quickly load an injection to an injector and to improve efficiency for charging the injection to a syringe. CONSTITUTION: An apparatus for filling a syringe(101) comprises a storage tank(110), an injector(133), a feeding tube(115), and a first sound pressure generating member(131). The storage tank stores an injection. The injector injects the injection to a syringe(160). The feeding tube connects the storage tank and the injector. The first sound pressure generating member is installed in the injector and draws in fluid in the syringe.

Description

Syringe filling device and syringe filling method {PREFILLED SYRINGE FILLING MACHINE AND PREFILLED SYRINGE FILLING METHOD}

The present invention relates to a syringe filling device and a syringe filling method, and more particularly, to a syringe filling device and a syringe filling method capable of quickly injecting an injection liquid into a syringe without generating bubbles.

Conventional injection solutions have been widely used in which ampoules are opened and injected into syringes just before they are stored in ampoules and introduced into a living body. However, when the ampoule was made of glass and the ampoule was broken, the problem of glass fragments being introduced into the ampoule frequently became a social problem. In addition, when injecting the injection solution into the ampoule, the injection solution is wasted because more injection solution than the actual amount to be injected into the ampoule.

In order to solve this problem, a prefilled syringe has appeared, and this syringe serves to inject the injection into the human body as well as to store the injection.

Prefilled syringes, called prefilled syringes, receive the injection directly from the tank in which it is stored and serve to store a certain amount of the injection.

An apparatus for filling an injection liquid into such a prefilled syringe needs to continuously fill an injection liquid into a large number of syringes in order to improve productivity. For this purpose, an apparatus for injecting injection liquid at a time to a plurality of syringes arranged in a tray is used. In such a filling device, when the viscosity of the injection liquid is large, there is a problem in that bubbles are generated during injection of the injection liquid into the syringe due to air remaining in the syringe.

The present invention has been made to solve the above problems, an object of the present invention to provide a syringe filling device and a syringe filling method that can improve the efficiency of filling the injection liquid.

A syringe filling apparatus according to an aspect of the present invention includes a storage tank in which an injection liquid is stored, an ejector for injecting the injection liquid into a syringe, a supply pipe connecting the storage tank and the ejector, and an air inside the syringe. It includes a first negative pressure forming member for sucking the.

The first negative pressure forming member may be fixedly installed on the lower support member connected to the injection tube, and the first negative pressure forming member may have a tubular structure having elasticity.

A vacuum pump for sucking air may be connected to the first negative pressure forming member, and a vacuum chamber may be provided between the vacuum pump and the first negative pressure forming member to provide a space in which negative pressure is formed.

The pressure tube connecting the first negative pressure forming member and the vacuum pump may be provided with a first pressure valve for controlling the connection between the vacuum chamber and the first negative pressure forming member, and the pressure tube controls the connection to the atmosphere. A second pressure valve can be installed.

A third pressure valve may be installed between the vacuum chamber and the vacuum pump to control communication between the vacuum chamber and the vacuum pump, and the positive pressure forming member may be installed in the ejector to increase the pressure inside the syringe. A second pressure valve may be installed between the positive pressure forming member and the syringe.

The positive pressure forming member may be a pump, and the positive pressure forming member may be a tank in which an inert gas is stored.

The discharger has an injection tube inserted into the syringe to inject the injection liquid into the syringe, the injection tube can be installed to be movable through the first negative pressure forming member, the first negative pressure forming member is a corrugated pipe It may be made in the form.

The syringe filling device may further include a pressure adjusting member for inserting a nozzle of the syringe to apply a negative pressure through the nozzle, wherein the pressure adjusting member is configured to vacuum the pressure chamber and the pressure inside the pressure chamber to a negative pressure state. It may include a pump. The pressure regulating member may include a sealing member installed in the pressure chamber and having a hole into which the nozzle is inserted.

It is installed between the discharger and the storage tank, and may include an intermediate container for delivering the injection liquid introduced from the storage tank to a fraudulent syringe, the intermediate container is provided with a piston to be inserted into the intermediate container and moveable, The piston may be connected to a servo motor that adjusts the position of the piston.

The supply pipe is connected to the upper end of the storage tank, the storage tank includes a body having an internal space for storing the injection liquid and a piston for reciprocating the inside of the body, the piston is installed in the lower portion of the body, The injection liquid may be positioned on an upper portion of the piston, and the storage tank may include a rod connected to the piston and installed in connection with the bottom of the body, and a transfer member connected to the rod to transfer the piston.

And a second negative pressure forming member coupled to a support rod having a stopper inserted into the syringe and a syringe storing the injection liquid to suck air in the syringe, wherein the second negative pressure forming member has a tubular shape. The support rod may be installed to move through the negative pressure forming member.

A vacuum pump for sucking air may be connected to the second negative pressure forming member, and a vacuum chamber may be installed between the vacuum pump and the second negative pressure forming member to provide a space in which a negative pressure is formed, and the syringe may be disposed therein. It may further include a microwave generator for inserting and generating a microwave.

According to another aspect of the present invention, a syringe filling apparatus includes a storage tank in which an injection liquid is stored, an ejector for injecting the injection liquid into a syringe, a supply pipe connecting the storage tank and the ejector, and air inside the syringe in which the injection liquid is stored. And a second negative pressure forming member for sucking and a vacuum pump in communication with the second negative pressure forming member.

The second negative pressure forming member may be formed in a tubular shape having elasticity, and a vacuum chamber may be installed between the vacuum pump and the second negative pressure forming member to provide a space in which a negative pressure is formed.

The pressure tube connecting the first negative pressure forming member and the vacuum pump may be provided with a first pressure valve for controlling communication between the vacuum chamber and the first negative pressure forming member, and the pressure tube controls the connection to the atmosphere. A second pressure valve can be installed.

According to another aspect of the present invention, a syringe filling device includes a storage tank including a body having an internal space in which injection liquid is stored, and a piston reciprocating inside the body, an ejector for injecting the injection liquid into the syringe, and the storage tank. And a supply pipe connecting the ejector, the supply pipe is connected to an upper end of the storage tank, and the piston is installed to press the injection liquid from a lower part to an upper part.

The piston is located at the bottom of the body, the storage tank may include a rod connected to the piston and connected to the bottom of the body, the transfer member for transporting the piston may be connected to the rod. . In addition, the transfer member may include any one selected from the group consisting of a pneumatic actuator, a hydraulic actuator, an electric actuator, and a servo motor.

According to another aspect of the present invention, a syringe filling apparatus includes a storage tank in which an injection liquid is stored, an ejector for injecting the injection liquid into a syringe, a supply pipe connecting the storage tank and the ejector, and a stopper inserted into the syringe injecting the injection liquid. And a support member installed and coupled to the syringe and forming a flow path through which the gas moves between the stopper and the syringe.

The vent member may be formed in a tubular shape, and a flow path extending in a height direction may be formed inside the wall surface, and the vent member may be formed at a cylindrical end portion formed in a cylindrical shape and a longitudinal end portion of the cylindrical tube portion, and may be formed from the cylindrical tube portion to the other end portion. It may include a fallopian tube portion configured to gradually increase in diameter. In addition, the flow path may be formed in a groove shape on the outer surface of the vent member.

According to another aspect of the present invention, a syringe filling apparatus includes a storage tank in which an injection liquid is stored, an ejector for injecting the injection liquid into a syringe, a supply pipe connecting the storage tank and the ejector, and the syringe injecting the injection liquid is inserted therein. And a microwave generator for generating microwaves.

According to an aspect of the present invention, there is provided a method for filling a syringe, the method comprising: inhaling air inside the syringe by bringing a first negative pressure forming member that sucks air into a syringe, injecting an injection liquid into the syringe in a negative pressure state, and And a first negative pressure forming member separating step of separating the first negative pressure forming member from the syringe.

The suctioning of the air may be performed by lowering the pressure inside the vacuum chamber such that the pressure inside the vacuum chamber provided between the first negative pressure forming member and the vacuum pump becomes a negative pressure using a vacuum pump connected to the first negative pressure forming member. And communicating the vacuum chamber and the first negative pressure forming member using a first pressure valve installed in a pressure pipe connecting the vacuum chamber and the first negative pressure forming member.

The suctioning of the air may further include applying a negative pressure to the nozzle of the syringe by using a pressure adjusting member into which the nozzle of the syringe is inserted, and applying the negative pressure to the nozzle may control the nozzle. And inserting the member into the member and sucking the gas inside the syringe through the nozzle through the pressure adjusting member.

In the separating of the first negative pressure forming member, the pressure inside the syringe may be made atmospheric by opening a second pressure valve installed in the pressure tube, and then the first negative pressure forming member may be separated from the syringe. In the separating of the first negative pressure forming member, the pressure inside the syringe is made higher than atmospheric pressure by supplying gas into the syringe by using a positive pressure forming member connected to an ejector for injecting the injection liquid into the syringe. 1 negative pressure forming member can be separated from the syringe.

The injecting the injection liquid may include an intermediate container storage step of transferring the injection liquid stored in the storage tank to the intermediate container. In the intermediate container storage step, the piston may be rotated by the rotation of a servo motor installed in the intermediate container according to the injection liquid volume of the input syringe. The injection liquid may be stored in the intermediate container by the amount of the injection liquid that has been moved so as to be input.

In the step of injecting the injection liquid may be inserted so that the tip of the injection tube for discharging the injection liquid to the syringe adjacent to the bottom of the syringe, and then raise the ejector while discharging the injection liquid, the rising speed of the ejector It may be equal to the rate of rise of the surface of the injection. In addition, in the step of injecting the injection liquid, after the injection of the injection is completed, the injection liquid remaining at the tip of the injection tube can be sucked into the intermediate container.

The syringe filling method includes a storage tank injection step of injecting injection liquid into a storage tank and an intermediate container storage step of transferring the injection liquid stored in the storage tank to an intermediate container, wherein the storage tank injection step injects injection liquid into the storage tank. Thereafter, the storage tank may be included in the defoaming apparatus to remove the bubbles contained in the injection liquid.

In the intermediate container storage step, by pushing the piston installed in the storage tank to discharge the air located in the upper portion, the injection liquid can be moved to the intermediate container.

The syringe filling method may further include a microwave irradiation step of injecting a microwave into the injection liquid stored in the syringe after the injection liquid is injected into the syringe.

The syringe filling method may further include connecting the second negative pressure forming member installed at the tip of the stopper installer to the syringe filled with the injection liquid to discharge air inside the syringe and inserting the stopper into the syringe. .

As described above, according to the present invention, the injection liquid can be loaded quickly and safely with the ejector, and the efficiency of filling the syringe with the injection liquid is improved.

1 is a front view showing a syringe filling device according to a first embodiment of the present invention.
2 is a perspective view showing a part of the syringe filling apparatus according to the first embodiment of the present invention.
3 is a block diagram showing the initial stage of injection injection in the syringe filling apparatus according to the first embodiment of the present invention.
Figure 4 is a block diagram showing the completion of the injection of the injection in the syringe filling apparatus according to the first embodiment of the present invention.
5 is a block diagram showing a part of a syringe filling apparatus according to a second embodiment of the present invention.
6 is a block diagram showing a syringe filling apparatus according to a third embodiment of the present invention.
7 is a perspective view showing a pressure regulating member of the syringe filling apparatus according to the third embodiment of the present invention.
8 is a block diagram showing a syringe filling apparatus according to a fourth embodiment of the present invention.
9 is a block diagram showing a storage tank and a defoaming device of the syringe filling apparatus according to a fourth embodiment of the present invention.
10 is a block diagram showing a syringe filling apparatus according to a fifth embodiment of the present invention.
11 is a cutaway perspective view illustrating a vent member installed in a syringe filling apparatus according to a fifth embodiment.
12A to 12C are views illustrating a process of installing a stopper using the vent member according to the fifth embodiment.
13 is a cutaway perspective view illustrating a vent member according to a modification of the fifth embodiment of the present invention.
14 is a block diagram showing a microwave generating unit of the syringe filling apparatus according to the sixth embodiment.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

1 is a front view showing a syringe filling apparatus according to a first embodiment of the present invention, Figure 2 is a perspective view showing a part of the syringe filling apparatus according to a first embodiment of the present invention.

Referring to FIGS. 1 and 2, the syringe filling apparatus 101 according to the present embodiment includes a storage tank 110 storing an injection liquid, an ejector 133 for injecting the injection liquid into the syringe, and a storage tank 110. And a supply pipe 115 connecting the ejector 133 and the first negative pressure forming member 131 installed in the ejector 133 to suck air in the syringe 160.

The injection solution may be a high viscosity injection solution, and in this embodiment, a bioprotein having a high viscosity of 10,000 cps (centi poise) to 1,000,000 cps will be described as an example. However, the present invention is not limited thereto, and the syringe filling device according to the present invention may be applied in filling an injection liquid having various viscosities.

The storage tank 110 has a space for receiving the injection liquid, and the storage tank 110 is provided with a piston for pushing the injection liquid. In the present exemplary embodiment, the injection liquid is pushed out by the piston, but the present invention is not limited thereto, and the injection liquid may be pushed out with a pump or the like.

The intermediate container 121 is installed in the storage tank 110, and the intermediate container 121 serves to deliver the injection liquid delivered from the storage tank 110 to the ejector 133.

The piston 123 is installed in the intermediate container 121 to be movable, and the servo motor 125 for adjusting the position of the piston 123 is connected to the piston 123.

Accordingly, the moving speed and the position of the piston 123 may be freely adjusted according to the rotation of the servo motor 125. The intermediate container 121 may contain an injection liquid injected into one syringe 160. When the injection liquid injected into one syringe 160 is accommodated in the intermediate container 121, the intermediate container 121 is installed as many as the number of syringes 160.

However, the capacity of the intermediate container 121 may be freely set according to the movement of the piston. Accordingly, the intermediate container 121 may supply the injection liquid of various capacities according to the capacity of the syringe 160 to the syringe. In the conventional filling apparatus, since the injection liquid is discharged by pneumatic pressure from the intermediate container, it is impossible to change the supply amount of the injection liquid. Accordingly, when the amount of injection liquid injected into the syringe 160 has to be changed, there is a problem in that the intermediate container needs to be replaced. In particular, high-viscosity injections are very slow, so it takes a lot of time to refill the injection in the intermediate container and inject the injection into the syringe.

However, according to the present embodiment, since the capacity of the intermediate container 121 can be freely adjusted by the servo motor 125, injection liquids of various capacities can be supplied to the syringe 160. In addition, the injection speed of the injection liquid can be freely adjusted, and the position of the piston can be controlled to store the injection liquid in an amount that can be injected into the syringe a plurality of times, and the injection liquid stored in the intermediate container 121 can be injected into the syringe 160 multiple times. have.

The intermediate container 121 is provided with a first supply valve 124 that controls the connection with the storage tank 110 and a second supply valve 126 that controls the communication between the ejector 133.

When the first supply valve 124 is opened to store the injection liquid in the intermediate container 121, the first supply valve 124 is closed and the second supply valve 126 is opened to inject the injection liquid into the syringe 160.

On the other hand, the injection liquid discharged from the intermediate container 121 is delivered to the ejector 133 through the connecting pipe 127. The ejector 133 is installed on the plate-shaped ejection support 135, and the support 135 fixes the ejector 133 and the stopper installer 136.

The support is fixed to the frame 129, which forms the frame of the syringe filling device 101, and supports the intermediate container 121, the ejector 133, the stopper installer 136 and the like.

The syringe 160 is inserted into the tray 158 and a plurality of syringes 160 may be installed in the tray 158. The tray 158 is installed to be movable by the transfer device 149 with respect to the bottom support member 148.

3 is a block diagram showing an initial stage of injection injection in the syringe filling apparatus according to a first embodiment of the present invention, Figure 4 is a step of completing the injection of the injection in the syringe filling apparatus according to a first embodiment of the present invention The configuration diagram shown.

Referring to FIGS. 3 and 4, the ejector 133 includes an injection tube 134 which is inserted into a syringe to eject the injection liquid into the syringe, and at the tip of the ejector 133, a first negative pressure forming member ( 131 is fixedly installed. In the present description, the negative pressure means a pressure lower than atmospheric pressure. The injection tube 134 is installed to be movable through the first negative pressure forming member 131.

The first negative pressure forming member 131 is installed to communicate with the vacuum pump 143 and the vacuum chamber 142 through the pressure tube 141. The pressure tube 141 is provided with a first pressure valve 145 for controlling communication between the vacuum chamber 142 and the first negative pressure forming member 131. In addition, the pressure pipe 141 is provided with a second pressure valve 146 for controlling the communication between the pressure pipe 141 and the atmosphere, the second pressure valve 146 is the first negative pressure forming member 131 and the first pressure valve. The connection between the 145 is installed.

In addition, a third pressure valve 147 is installed between the vacuum pump 143 and the vacuum chamber 142 to control communication between the vacuum pump 143 and the vacuum chamber 142.

The first negative pressure forming member 131 is formed in a tubular shape having elasticity and is in close contact with the flange 162 formed on the upper end of the syringe 160. The syringe 160 is formed of a pipe 161 and a flange 162 formed at the top of the pipe 161 and a nozzle is formed at the bottom.

When the first negative pressure forming member 131 has a tubular shape having elasticity, the first negative pressure forming member 131 may be in close contact with the syringe 160 without damaging the syringe 160. The vacuum pump 143 sucks air and makes the inside of the vacuum chamber 142 into a negative pressure state lower than atmospheric pressure. The pressure inside the vacuum chamber 142 is set to sufficiently remove the air inside the syringe 160. When the pressure inside the vacuum chamber 142 is sufficiently low, the third pressure valve 147 is closed, and the first pressure valve 145 is opened to move the air inside the syringe 160 to the vacuum chamber 142. Alternatively, the injection liquid is injected into the syringe 160 at the same time as the movement.

Accordingly, bubbles may be prevented from occurring in the injection liquid due to air remaining in the syringe 160, and even fine bubbles remaining in the first injection liquid may be removed. If bubbles are present in the injection solution, it may be harmful to the human body. However, in the case of a high viscosity injection solution, unlike the general low viscosity injection solution, there is a problem in that bubbles in the injection solution are not easily removed, so it is very important to remove bubbles in the high viscosity injection solution.

In particular, according to the present exemplary embodiment, after the vacuum pump 143 is not directly connected to the syringe 160, and the vacuum pump 143 and the vacuum chamber 142 are blocked, the vacuum chamber 142 in which the negative pressure is generated is supplied with air. By inhaling, it does not affect the pulsation of the vacuum pump 143 and the like, and generates a vacuum pressure equal to the set pressure, thereby efficiently removing the air inside the syringe 160.

If the vacuum pressure is too large, a large viscosity injection solution may swell and may overflow to the outside of the syringe 160. This is because the injection liquid swells as the volume of the very fine bubbles remaining inside the injection liquid increases, and according to the present embodiment, the vacuum chamber 142 may be applied to the syringe 160 as much as the set pressure. have.

After the injection of the injection is completed, the first pressure valve 145 is closed and the second pressure valve 146 is opened. Accordingly, the pressure inside the syringe 160 becomes atmospheric pressure, so that the first negative pressure forming member 131 and the syringe 160 can be safely separated.

On the other hand, the syringe filling device 101 has a stopper inserter 136 for installing a stopper 137 that blocks the open end of the syringe 160 into which the injection liquid is injected. The stopper inserter 136 is fixed to the support 135, and the second negative pressure forming member 132 is installed at the tip of the stopper inserter 136 in the same manner as the ejector 133. The second negative pressure forming member 132 is installed to communicate with the vacuum pump 153 and the vacuum chamber 152 through the pressure tube 151. The pressure tube 151 is provided with a first pressure valve 155 for controlling communication between the vacuum chamber 152 and the second negative pressure forming member 132. In addition, the pressure pipe 151 is provided with a second pressure valve 156 that controls the communication between the pressure pipe 151 and the atmosphere, the second pressure valve 156 is the second negative pressure forming member 132 and the first pressure valve. 155 is installed between.

The second pressure valve 156 may be provided with a positive pressure forming member for supplying air or inert gas into the syringe 160. Accordingly, the second negative pressure forming member 132 and the syringe 160 may be easily separated by supplying gas into the syringe 160 using the positive pressure forming member after inserting the stopper 137.

In addition, a third pressure valve 157 is installed between the vacuum pump 153 and the vacuum chamber 152 to control communication between the vacuum pump 153 and the vacuum chamber 152.

In the present exemplary embodiment, a separate vacuum pump 153 and a vacuum chamber 152 are illustrated in the second negative pressure forming member 132, but the present invention is not limited thereto, and the second negative pressure forming member 132 is provided. A vacuum pump and a vacuum chamber connected to the first negative pressure forming member 131 may be connected to the vacuum chamber.

The second negative pressure forming member 132 is formed in a tubular shape having elasticity and is in close contact with the flange 162 formed on the upper end of the syringe. The stopper 137 and the support rod 138 are installed to penetrate the second negative pressure forming member 132 and move upward and downward.

The vacuum pump 153 sucks air and makes the inside of the vacuum chamber 152 into a negative pressure state lower than atmospheric pressure. The pressure inside the vacuum chamber 152 is set to sufficiently remove the air inside the syringe 160. When the pressure inside the vacuum chamber 152 is sufficiently low, the third pressure valve 157 is closed, and the first pressure valve 155 is opened to suck air in the syringe 160, and in this state, the support rod 138 is closed. Inject the stopper 137 suspended in the) into the syringe 160. Accordingly, the stopper 137 is easily inserted into the syringe 160 according to the pressure difference.

If the second negative pressure forming member 132 is not installed, a problem arises in that the stopper 137 cannot be inserted into the syringe 160 due to the pressure inside the syringe 160.

 However, when the second negative pressure forming member 132 is installed in the stopper inserter 136 as in the present embodiment, the stopper 137 may be more easily inserted by lowering the pressure inside the syringe 160.

After the stopper 137 is inserted, the first pressure valve 155 is closed and the second pressure valve 156 is opened. Accordingly, the pressure inside the syringe 160 becomes atmospheric pressure, so that the second negative pressure forming member 132 and the syringe 160 can be safely separated.

Hereinafter, a method of filling a syringe using a syringe filling apparatus according to the present embodiment will be described.

In the syringe filling method according to the present embodiment, the first negative pressure forming member 131 is brought into close contact with the syringe 160 to inhale air in the syringe and the injection of the injection liquid into the syringe 160 in a negative pressure state; And separating the first negative pressure forming member 131 from the first negative pressure forming member 131 from the syringe 160.

Intake of the air may be performed by lowering the pressure inside the vacuum chamber 142 and closing the third pressure valve 147 using the vacuum pump 143 such that the pressure inside the vacuum chamber 142 becomes a set negative pressure. Opening the first pressure valve 145 to connect the vacuum chamber 142 and the first negative pressure forming member 131.

Injecting the injection liquid further comprises an intermediate container storage step of transferring the injection liquid stored in the storage tank 110 to the intermediate container 121. In the intermediate container storage step, the first supply valve 124 is opened, and the piston 123 is moved by the rotation of the servo motor 125 installed in the intermediate container 121 according to the injection liquid volume of the input syringe. The injection liquid is stored in the intermediate container 121 by the dose.

Accordingly, when the injection volume of the syringe 160 is changed, the injection amount of the changed injection liquid is stored in the intermediate container 121, so that the injection liquid may be stored in the syringe without replacing the intermediate container 121 even if the injection liquid volume is changed. .

In addition, the step of injecting the injection liquid closes the first supply valve 124, opens the second supply valve 126, and controls the position of the piston 123 installed in the intermediate container 121 with the servo motor 125. Then, the injection liquid is pushed out of the intermediate container 121 to move the injection liquid from the ejector 133 to the syringe 160.

In addition, when the injection liquid is moved from the ejector 133 to the syringe 160, the tip of the injection tube 134 installed in the lower part of the ejector 133 is inserted to be adjacent to the bottom of the syringe 160, and then the injection liquid is removed from the bottom. Is injected, and the ejector 133 is raised in accordance with the speed at which the injection liquid rises. At this time, the rising speed of the ejector 133 and the rising speed of the injection liquid are adjusted so that the injection liquid does not touch the tip of the ejector 133, and the rising speed of the surface of the injection liquid and the rising speed of the ejector 133 are equally adjusted. . This is because when the injection liquid comes into contact with the tip of the ejector 133, not only the injection liquid is wasted but also the amount of the injection liquid is reduced, which makes it difficult to inject it at a set weight. Typically, bioprotein is expensive so that the price of one syringe reaches millions, so the production cost is greatly increased when the injection liquid reaches the ejector 133.

On the other hand, when the injection of the injection is completed, the piston 123 is raised by using the servo motor 125 to suck the injection liquid remaining at the tip of the ejector 133 into the intermediate container. If the injection liquid remaining at the tip of the ejector 133 falls into the syringe 160, the amount of the injection liquid may change. If the injection liquid remaining at the tip of the ejector 133 falls in the process of moving to the next process, The problem is that the equipment is contaminated. However, according to the present embodiment, after the injection is completed, it is possible to solve the problem of dropping the injection liquid by inhaling the injection liquid.

In the separating step of the first negative pressure forming member 131, the pressure inside the syringe 160 is made atmospheric by opening the second pressure valve 146 connected to the atmospheric pressure, and then the first negative pressure forming member 131 is separated from the syringe. .

In addition, the syringe filling method according to the present embodiment connects the second negative pressure forming member 132 installed at the tip of the stopper installer 136 to the syringe 160 filled with the injection liquid to discharge the air inside the syringe 160. And inserting and installing the stopper 137 into the syringe 160. Here, the step of discharging the air may be performed by sucking the air with the vacuum pump 153 to make the interior of the vacuum chamber 152 at a negative pressure lower than atmospheric pressure, and communicating the vacuum chamber 152 and the syringe 160 to the inside of the syringe. Moving air to the vacuum chamber 152.

5 is a block diagram showing a part of a syringe filling apparatus according to a second embodiment of the present invention.

Referring to FIG. 5, the syringe filling device 102 according to the present embodiment is the same as the other syringe filling device in the above-described first embodiment except for the structures of the ejector 170 and the positive pressure forming member 148. Since the structure is made of a duplicate description of the same structure is omitted.

The ejector 170 according to the present embodiment has a cylindrical tubular shape and has a corrugated pipe part 171. The ejector 170 according to the present embodiment becomes a negative pressure forming member and is formed of a material having elasticity. Accordingly, the ejector 170 may be contracted in the longitudinal direction and may be stably in close contact with the syringe 160 while minimizing an impact applied to the syringe 160 when the ejector 170 is in close contact with the syringe 160.

In the ejector 170, the vacuum pump 143 and the vacuum chamber 142 are installed to communicate with each other via the pressure tube 141. The pressure tube 141 is provided with a first pressure valve 145 for controlling communication between the vacuum chamber 142 and the ejector 170. In addition, the pressure pipe 141 is provided with a second pressure valve 146 for controlling the communication between the pressure pipe 141 and the positive pressure forming member 148, the second pressure valve 146 and the first negative pressure forming member 131 It is connected between the first pressure valve 145.

In addition, a third pressure valve 147 is installed between the vacuum pump 143 and the vacuum chamber 142 to control communication between the vacuum pump 143 and the vacuum chamber 142.

The positive pressure forming member 148 is connected to the discharger 133 through a pressure tube, and the pump and the positive pressure forming member 148 may be a tank in which an inert gas is stored. Here, the inert gas may be various kinds of gases that do not react with the injection liquid as well as the halogen group gas.

When the injection of the injection liquid into the syringe 160 is completed, the first pressure valve 145 is closed and the second pressure valve 146 is opened to supply air or an inert gas to the syringe 160. When the positive pressure forming member 148 is formed of a pump, air is supplied to the syringe 160, and in the case of a tank, the syringe 160 is provided with an inert gas. When the positive pressure forming member 148 is installed as in this embodiment, the injection liquid is injected, and then the ejector 170 can be more easily separated from the syringe 160 by forming a pressure inside the syringe 160 higher than atmospheric pressure. have.

The syringe filling method according to the present embodiment supplies a gas into the syringe 160 by using a positive pressure forming member 148 installed in communication with the syringe 160 in the first negative pressure forming member 131 separating step. After the internal pressure is higher than atmospheric pressure, the first negative pressure forming member 131 is separated from the syringe.

6 is a block diagram showing a syringe filling apparatus according to a third embodiment of the present invention, Figure 7 is a perspective view showing a pressure regulating member of the syringe filling apparatus according to a third embodiment of the present invention.

6 and 7, the syringe filling device 103 according to the present embodiment has the same structure as the syringe filling device according to the first embodiment except the pressure adjusting member 116. Duplicate description of the same structure is omitted.

In this embodiment, a plurality of syringes are installed in the tray, and the injection liquid is injected into the plurality of syringes at the same time.

The syringe filling device 103 according to the present embodiment includes a pressure regulating member 116 into which a part of the syringe 160 is inserted. The pressure regulating member 116 inserts a lower portion of the syringe 160 in which the nozzle 165 is formed in the syringe 160. At this time, the nozzle 165 is fully inserted into the pressure regulating member 116.

In the present description, the nozzle 165 means a portion from which the injection liquid is ejected when the injection liquid is injected into the injection target, and generally means a narrow tube formed at the bottom of the syringe 160.

The nozzle 165 is provided with a stopper 163, but a leak of pressure may occur between the nozzle 165 and the stopper 163 due to a failure of the stopper 163 or the like. In particular, when the pressure inside the syringe 160 is formed at the negative pressure using the first negative pressure forming member 131, a problem may occur in that gas is introduced through the nozzle 165 to form a desired negative pressure.

The pressure adjusting member 116 prevents the pressure inside the syringe 160 from leaking through the nozzle 165. In addition, the pressure adjusting member 116 applies a negative pressure through the nozzle 165 so that the pressure inside the syringe 160 may maintain a negative pressure state, and for this purpose, the pressure adjusting member 116 sucks gas inside the syringe 160. However, when the inside of the syringe 160 is in a vacuum state or a negative pressure state, only the negative pressure may be applied without suction of gas.

To this end, the pressure regulating member 116 is installed in the box-shaped pressure chamber 116a and the pressure chamber 116a and includes a sealing member 116c in which a hole 116d is formed. The sealing member 116c is formed in a ring shape having elasticity, and the lower portion of the syringe 160 is inserted into � €€ 116d formed in the sealing member 116c. The sealing member 116c is made of a material having elasticity to be in close contact with the outer surface of the syringe 160, thereby preventing gas from leaking between the syringe 160 and the pressure regulating member 116.

A plurality of sealing members 116c are installed in the pressure chamber 116a so that the plurality of syringes 160 may be inserted into the pressure chamber 116a at the same time.

In addition, the pressure regulating member 116 further includes a vacuum pump 116b that sucks gas in the pressure chamber 116a to make the inside of the pressure chamber 116a into a negative pressure state. The pressure inside the pressure chamber 116a is equal to or less than the sound pressure generated by the first negative pressure forming member 131. Lower sound pressure here means a smaller difference from atmospheric pressure. This is because if the pressure inside the pressure chamber 116a is greater than the negative pressure generated by the first negative pressure forming member 131, the injection liquid may be discharged through the nozzle 165 during the injection of the injection liquid. However, when the pressure inside the pressure chamber 116a is equal to or less than the pressure formed by the first negative pressure forming member 131, even if a negative pressure is formed in the nozzle 165, the injection liquid is prevented from being discharged through the nozzle 165. can do. The pressure inside the pressure chamber 116a is preferably the same as the pressure formed by the first negative pressure forming member 131, but even if the pressure is slightly smaller than this, leakage of pressure is insignificant so that the inside of the syringe can be maintained in a negative pressure state. .

When the pressure adjusting member 116 into which the lower portion of the syringe 160 is inserted as in the present embodiment is installed, when the pressure inside the syringe 160 is maintained at a negative pressure using the first negative pressure forming member 131, the nozzle 165 ) Can prevent the pressure from leaking.

When the pressure inside the syringe 160 is negatively formed using the first negative pressure forming member 131, leakage of pressure may occur in a gap between the nozzle 165 and the stopper 163. However, after the pressure inside the pressure chamber 116a is made negative, as shown in the present embodiment, when a part of the syringe 160 is inserted into the pressure chamber 116a, the negative pressure is also applied to the nozzle 165 through the nozzle 165. The leakage of pressure can be prevented stably.

On the other hand, the syringe filling method according to the present embodiment is to inhale the air in the syringe 160 by bringing the first negative pressure forming member 131 for inhaling air in close contact with the syringe 160, and the syringe 160 in the negative pressure state Injecting the injection solution into the inside, and the first negative pressure forming member 131 separating the first negative pressure forming member 131 from the syringe 160.

Inhaling the air may further include applying negative pressure to the nozzle 165 of the syringe 160 using the pressure adjusting member 116. The applying of the negative pressure to the nozzle 165 may include inserting the nozzle 165 into the pressure regulating member 116 and sucking the gas inside the syringe 160 through the nozzle 165 with the pressure regulating member 116. It may further comprise the step.

8 is a block diagram showing a syringe filling apparatus according to a fourth embodiment of the present invention, Figure 9 is a block diagram showing a storage tank and a defoaming device of the syringe filling apparatus according to a fourth embodiment of the present invention.

8 and 9, the syringe filling device 104 according to the present embodiment has the same structure as the syringe filling device according to the first embodiment except for the storage tank 112, and thus the same structure. Duplicate description of the structure is omitted.

Storage tank 112 according to the present embodiment is connected to the intermediate container 121 via the supply pipe 115 is installed.

The storage tank 112 has an internal space in which the injection liquid is stored and has a cylindrical body 112a and a piston 112b reciprocating inside the body 112a, and a rod-shaped rod connected to the piston 112b. 112c, and a conveying member 113 for conveying the piston 112b. The body 112a is formed of a substantially cylindrical cylinder, and the piston 112b is located at the bottom of the body 112a and the injection liquid is located at the top of the piston 112b. Accordingly, the piston 112b may push up the injection liquid stored in the storage tank 112 upwards, and the rod 112c is installed to extend from the piston 112b to the bottom of the body 112a. The storage tank 112 is connected to the transfer member 113 for transferring the piston (112b) is installed, the transfer member 113 is connected to the rod (112c) to transfer the piston (112b), pneumatic actuator, hydraulic actuator Or an electric actuator, a servo motor, or the like.

On the other hand, the supply pipe 115 is connected to the upper end of the storage tank 112a, in particular connected to the upper surface of the body 112a.

When the piston 12b pushes up the injection liquid from the lower side to the upper side as shown in the present embodiment, since the air located in the upper portion of the storage tank 112 is first discharged from the storage tank, the injection liquid is discharged to the intermediate container 121 after the air is exhausted. Injection can be prevented from pressurizing the air together with the injection liquid. When the piston 112b is installed on the upper portion and pressurized air together with the injection liquid as in the related art, air located between the piston 112b and the injection liquid melts into the injection liquid and bubbles may be generated in the injection liquid. However, when the piston 112b is pushed upward from the bottom as in the present embodiment, the injection liquid is pressurized after the air is discharged, thereby preventing the air inside the storage tank 112 from melting into the injection liquid.

On the other hand, the syringe filling method according to the present embodiment is to inhale the air in the syringe 160 by bringing the first negative pressure forming member 131 for inhaling air in close contact with the syringe 160, and the syringe 160 in the negative pressure state Injecting the injection solution into the inside, and the first negative pressure forming member 131 separating the first negative pressure forming member 131 from the syringe 160. In addition, the syringe filling method according to the present embodiment is a storage tank 112 injection step of injecting the injection liquid into the storage tank 112 is carried out before the step of inhaling air from the storage tank 112 to the intermediate container 121 The intermediate container 121 for moving the injection further comprises the step of storing.

As shown in FIG. 9, injecting the storage liquid into the storage tank 112, the storage tank 112 is injected, and then the storage tank 112 is placed in the defoaming apparatus 118 to remove bubbles contained in the injection liquid. Include. Here, the defoaming device 118 rotates the storage tank 112 to remove bubbles from the injection liquid or to heat the storage tank 112 to remove bubbles from the injection liquid.

After defoaming by using a degassing apparatus, when the injection liquid is injected into the storage tank 112, a problem occurs that air is infiltrated into the injection liquid in the process of injecting the defoamed injection liquid into the storage tank 112, thereby generating bubbles. However, after injecting the injection liquid into the storage tank 112 as in the present embodiment, by removing the bubbles of the injection liquid stored in the storage tank with a degassing apparatus after the degassing, it is possible to prevent the generation of bubbles because it does not go through the injection process.

In the intermediate container 121 storage step, the piston 112b is pushed up from the storage tank 112 to discharge air located at an upper portion thereof, and then the injection liquid is moved to the intermediate container 121. Accordingly, it is possible to prevent the air in the storage tank 112 from melting into the injection liquid during the pressurization of the injection liquid.

In the case of high viscosity injection solution, it is very important to remove air bubbles inside the injection solution. This is because bubbles can be easily melted into the injection solution, and unlike bubbles with low viscosity, once bubbles are generated, they are not discharged to the outside of the injection solution, making it difficult to remove the bubbles. However, according to the present embodiment, it is possible to stably prevent the bubbles from penetrating into the injection solution during the injection and movement of the injection solution by blocking the cause of the bubble in advance.

10 is a block diagram showing a syringe filling apparatus according to a fifth embodiment of the present invention, Figure 11 is a cutaway perspective view showing a vent member installed in the syringe filling device, Figures 12a to 12c according to the embodiment A diagram illustrating a process of installing a stopper using a vent member.

Referring to FIG. 10, the syringe filling device 105 according to the present exemplary embodiment may include a storage tank 110 storing an injection liquid and an intermediate container 121 receiving the injection liquid from the storage tank 110 and supplying the injection liquid to the syringe 160. And a vent member 180 inserted into the support rod 138 on which the stopper 137 is installed and the syringe 160 filled with the injection liquid, and a flow path through which gas flows in the wall.

The intermediate container 121, the support rod 138, and the vent member 180 are provided in the frame. In particular, the support rod 138 and the ventilation member 180 is installed to be movable in the vertical direction with respect to the frame.

The injection solution may be a low viscosity injection solution having a viscosity of 10,000 cps (centi poise) or less. The storage tank 110 has a space for receiving the injection liquid, and the storage tank 110 is provided with a piston for pushing the injection liquid. The intermediate container 121 is installed in the storage tank 110, and the intermediate container 121 serves to deliver the injection liquid delivered from the storage tank 110 to the syringe 160.

The piston 123 is installed in the intermediate container 121 to be movable, and the servo motor 125 for adjusting the position of the piston 123 is connected to the piston 123.

The intermediate container 121 is provided with a first supply valve 124 that controls the connection with the storage tank 110 and a second supply valve 126 that controls the communication between the ejector 133. On the other hand, the injection liquid discharged from the intermediate container 121 is delivered to the syringe 160 through the connecting pipe 127.

Referring to FIG. 11, the vent member 180 according to the present exemplary embodiment has a tubular shape, and includes a cylindrical tube portion 181 and a trumpet tube portion 182 formed on an upper portion of the cylindrical tube portion 181. do. The cylindrical tube portion 181 is made of a cylindrical shape with the same diameter in the height direction, the trumpet tube portion 182 is formed so as to increase in diameter from the cylindrical tube portion 181 toward the other end. A plurality of flow paths 183 extending in the height direction are formed in the pipe wall constituting the vent member 180 so that gas can pass therethrough. The flow path 183 according to the present embodiment is formed in a hole shape, but the present invention is not limited thereto, and it is sufficient to form a space in which gas moves between the syringe 160 and the stopper 137, and a groove It may also be in the form.

An installation process of the stopper 137 will be described with reference to FIGS. 12A to 12C.

As shown in FIG. 12A, the vent member 180 is first installed in the syringe 160 filled with the injection liquid. At this time, only the cylindrical tube portion 181 of the vent member 180 is inserted into the syringe 160. The injection liquid is made of a relatively low viscosity injection liquid, and the stopper 163 is coupled to the portion of the syringe in which the needle is installed.

As shown in FIG. 12B, the stopper 137 is pushed into the syringe using a support bar. At this time, the air inside the syringe 160 is discharged to the outside of the syringe 160 through the flow path 183 due to the increased pressure by entering the stopper 137. Accordingly, the stopper 137 can be easily installed without increasing the pressure inside the syringe 160.

As shown in FIG. 12C, when the stopper 137 is installed, the vent member 180 is removed.

13 is a cutaway perspective view illustrating a vent member according to a modification of the fifth embodiment of the present invention.

Referring to FIG. 13, the vent member 185 according to the present exemplary embodiment has a tubular shape, and includes a cylindrical tube portion 185a and a trumpet tube portion 185b formed on an upper portion of the cylindrical tube portion 185a. do. The cylindrical tube portion 185a is formed in a cylindrical shape with the same diameter in the height direction, and the bugle tube portion 185b is formed to increase in diameter from the cylindrical tube portion 185a toward the other end portion. On the outer surface of the pipe constituting the vent member 185, a plurality of groove-shaped flow paths 185c extending in the height direction are formed to allow gas to pass therethrough. The flow path 185c is formed in the shape of an arc-shaped groove recessed from the outer surface of the tube wall. Accordingly, when the stopper 137 is inserted into the syringe 160, the air inside the syringe can be easily moved to the outside through a flow path formed between the inner surface of the syringe 160 and the outer surface of the vent member 185. .

14 is a block diagram showing a microwave generating unit of the syringe filling apparatus according to the sixth embodiment.

The syringe filling apparatus according to the present exemplary embodiment has the same structure as the syringe filling apparatus according to the first embodiment, except that the microwave generator 190 is additionally provided, and thus, a redundant description of the same structure will be omitted. .

The microwave generator 190 has a chamber shape and a syringe 160 filled with an injection liquid is inserted into the microwave generator 190. At this time, the stopper is not installed in the syringe 160.

The microwave generator 190 further includes a microwave generator 191 installed at an upper portion thereof, and the microwave generator 191 may include a magnetron and a fan. Microwaves generated by the microwave generator 191 has a frequency of 300MHz to 300000MHz. In particular, the microwave may have a frequency of 2450 MHz that is the same as the resonant frequency of water, or may have the same or similar frequency as that of the injection liquid.

The syringe filling method according to the present embodiment includes a microwave irradiation step of injecting microwaves into the injection liquid stored in the syringe 160. In the microwave irradiation step, the syringe 160 is inserted into the microwave generator 190 having a chamber shape, and then the microwave is irradiated to the injection liquid.

When the syringe 160 filled with the injection liquid as in this embodiment is heated by microwave, the injection liquid can be sterilized. In addition, when the injection liquid is heated, fine bubbles in the injection liquid may be released to the outside of the injection liquid to remove the fine bubbles contained in the injection liquid.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, Of course.

101, 102, 103, 104, 105: syringe filling device
110, 112: storage tank 112a: body
112b: piston 112c: rod
113: transfer member 115: supply pipe
116: pressure regulating member 116a: pressure chamber
116b: vacuum pump 116c: sealing member
116d: hole 121: intermediate container
123: piston 124: first supply valve
125: servo motor 126: second supply valve
127 connector 129 frame
131: first negative pressure forming member 132: second negative pressure forming member
133: ejector 134: injection tube
135: support 136: stopper inserter
137: stopper 138: support rod
151. 151: pressure tube 142, 152: vacuum chamber
143 and 153: vacuum pump 145 and 155: first pressure valve
146, 156: second pressure valve 147, 157: third pressure valve
148: bottom support member 149: transfer device
151: pressure tube 152: vacuum chamber
153: vacuum pump 155: first pressure valve
156: second pressure valve 160: syringe
161: pipe portion 162: flange
163: nozzle 170: ejector
171: corrugated pipe portion 180: ventilation member
181: cylindrical tube 182: trumpet tube
183: Euro 190: Microwave Generator
191: microwave generator

Claims (51)

A storage tank in which the injection liquid is stored;
An ejector for injecting the injection liquid into a syringe;
A supply pipe connecting the storage tank and the discharger; And
A first negative pressure forming member installed in the discharger and sucking the fluid inside the syringe;
Syringe filling apparatus comprising a. The method according to claim 1,
The first negative pressure forming member is a syringe filling device made of a tubular shape having elasticity. The method according to claim 1,
The first negative pressure forming member is connected to a vacuum pump for sucking a fluid connected to the syringe filling device. The method of claim 3,
And a vacuum chamber is provided between the vacuum pump and the first negative pressure forming member to provide a space in which negative pressure is formed. The method of claim 3,
And a pressure valve connecting the first negative pressure forming member and the vacuum pump to a first pressure valve for controlling communication between the vacuum chamber and the first negative pressure forming member. 6. The method of claim 5,
The pressure tube is a syringe filling device is provided with a second pressure valve for controlling the connection to the atmosphere. The method according to claim 1,
And a third pressure valve is installed between the vacuum chamber and the vacuum pump to control communication between the vacuum chamber and the vacuum pump. The method according to claim 1,
The ejector is provided with a positive pressure forming member for increasing the pressure inside the syringe, a second pressure valve is provided between the positive pressure forming member and the syringe. The method of claim 8,
The positive pressure forming member is a syringe filling device consisting of a pump. The method of claim 8,
The positive pressure forming member is a syringe filling device consisting of a tank in which an inert gas is stored. The method according to claim 1,
And the ejector has an injection tube inserted into the syringe to inject an injection liquid into the syringe, the injection tube being installed to be movable through the first negative pressure forming member. The method according to claim 1,
The first negative pressure forming member is a syringe filling device made of a corrugated pipe form. The method according to claim 1,
And a pressure regulating member for inserting a nozzle of the syringe to apply a negative pressure through the nozzle. The method of claim 13,
The pressure regulating member includes a pressure chamber and a vacuum pump for making a pressure inside the pressure chamber to a negative pressure state. 15. The method of claim 14,
The pressure regulating member is a syringe filling device comprising a sealing member is formed in the pressure chamber and the hole is inserted into a portion of the syringe. The method according to claim 1,
And an intermediate container disposed between the discharger and the storage tank, the intermediate container transferring the injection liquid introduced from the storage tank to a fraudulent syringe. 17. The method of claim 16,
The intermediate container is provided with a piston is inserted into the intermediate container to be movable, the piston is connected to the servo motor for adjusting the position of the piston syringe filling device. The method according to claim 1,
The supply pipe is connected to the upper end of the storage tank,
The storage tank includes a body having an internal space in which the injection liquid is stored and a piston for reciprocating the inside of the body, the piston is installed in the lower portion of the body, the syringe filling apparatus is located in the upper portion of the piston. 19. The method of claim 18,
The storage tank is connected to the piston and the syringe filling device comprising a rod connected to the bottom of the body and the transfer member is connected to the rod to transfer the piston. The method according to claim 1,
And a second negative pressure forming member coupled to a support bar provided with a stopper inserted into the syringe and a syringe storing the injection liquid to suck air in the syringe. 21. The method of claim 20,
The second negative pressure forming member is made of a tubular shape, the support rod is a syringe filling device is installed so that the negative pressure forming member moves through. 21. The method of claim 20,
A vacuum pump for sucking air is connected to the second negative pressure forming member, and a vacuum chamber is provided between the vacuum pump and the second negative pressure forming member to provide a space in which a negative pressure is formed. The method according to claim 1,
The syringe filling apparatus further comprises a microwave generator for inserting the syringe to generate a microwave. A storage tank in which the injection liquid is stored;
An ejector for injecting the injection liquid into a syringe;
A supply pipe connecting the storage tank and the discharger;
A second negative pressure forming member for sucking air in the syringe in which the injection liquid is stored; And
A vacuum pump in communication with the second negative pressure forming member;
Syringe filling apparatus comprising a. 25. The method of claim 24,
The second negative pressure forming member is a syringe filling device made of a tubular shape having elasticity. 25. The method of claim 24,
And a vacuum chamber is provided between the vacuum pump and the second negative pressure forming member to provide a space in which negative pressure is formed. 27. The method of claim 26,
And a pressure valve connecting the first negative pressure forming member and the vacuum pump to a first pressure valve for controlling communication between the vacuum chamber and the first negative pressure forming member. 28. The method of claim 27,
The pressure tube is a syringe filling device is provided with a second pressure valve for controlling the connection to the atmosphere. A storage tank including a body having an internal space in which the injection liquid is stored and a piston reciprocating inside the body;
An ejector for injecting the injection liquid into a syringe; And
A supply pipe connecting the storage tank and the discharger;
Including,
The supply pipe is connected to the upper end of the storage tank, the syringe filling device installed to press the injection liquid from the lower part of the piston to the upper part. 30. The method of claim 29,
The piston is located at the bottom of the body and the injection liquid is located on the top of the piston,
And the storage tank is connected to the piston and includes a rod leading to the bottom of the body. 31. The method of claim 30,
A syringe filling device is provided with a conveying member for conveying the piston connected to the rod. The method of claim 31, wherein
The conveying member is a syringe filling device including any one selected from the group consisting of a pneumatic actuator, a hydraulic actuator, an electric actuator, and a servo motor. A storage tank in which the injection liquid is stored;
An ejector for injecting the injection liquid into a syringe;
A supply pipe connecting the storage tank and the discharger;
A support bar on which a stopper is inserted into the syringe into which the injection liquid is injected; And
A ventilation member inserted into the syringe and forming a flow path through which the fluid moves between the stopper and the syringe;
Syringe filling apparatus comprising a. The method of claim 33, wherein
The vent member is made of a tubular shape, the syringe filling device formed with a flow path extending in the height direction inside the wall. The method of claim 33, wherein
The vent member includes a cylindrical tube portion formed in a cylindrical shape and a trumpet tube portion formed at a longitudinal end of the cylindrical tube portion and configured to increase in diameter from the cylindrical tube portion toward the other end portion. The method of claim 33, wherein
The flow path is a syringe filling device formed in the groove shape on the outer surface of the vent member. A storage tank in which the injection liquid is stored;
An ejector for injecting the injection liquid into a syringe;
A supply pipe connecting the storage tank and the discharger; And
A microwave generator configured to generate a microwave by inserting the syringe into which the injection liquid is injected;
Syringe filling apparatus comprising a. Sucking the air inside the syringe by bringing the first negative pressure forming member that sucks air into close contact with the syringe;
Injecting injection into the syringe under negative pressure; And
A first negative pressure forming member separating step of separating the first negative pressure forming member from a syringe;
Syringe filling method comprising a. The method of claim 38, wherein
The suctioning of the air may be performed by lowering the pressure inside the vacuum chamber such that the pressure inside the vacuum chamber provided between the first negative pressure forming member and the vacuum pump becomes a negative pressure using a vacuum pump connected to the first negative pressure forming member. And communicating the vacuum chamber with the first negative pressure forming member using a first pressure valve installed in a pressure tube connecting the vacuum chamber and the first negative pressure forming member. The method of claim 38, wherein
Inhaling the air further comprises the step of applying a negative pressure to the nozzle of the syringe by using a pressure adjusting member inserted into the nozzle of the syringe. 41. The method of claim 40 wherein
The applying of the negative pressure to the nozzle includes inserting a portion of the syringe into the pressure regulating member and applying the negative pressure to the nozzle with the pressure regulating member. The method of claim 39,
The separating of the first negative pressure forming member may include opening the second pressure valve installed in the pressure pipe to make the pressure inside the syringe at atmospheric pressure, and then separating the first negative pressure forming member from the syringe. The method of claim 39,
In the separating of the first negative pressure forming member, the pressure inside the syringe is made higher than atmospheric pressure by supplying gas into the syringe by using a positive pressure forming member connected to an ejector for injecting the injection liquid into the syringe. Syringe filling method for separating the forming member from the syringe. The method of claim 38, wherein
Injecting the injection liquid comprises the intermediate container storage step of transferring the injection liquid stored in the storage tank to the intermediate container,
In the intermediate container storage step, a syringe filling method for storing the injection liquid in the intermediate container by moving the piston by the rotation of the servo motor installed in the intermediate container according to the injection liquid volume of the input syringe. The method of claim 38, wherein
And injecting the injection liquid, inserting a tip of an injection tube discharging the injection liquid into the syringe so as to be adjacent to the bottom of the syringe, and then raising the discharger while discharging the injection liquid. 46. The method of claim 45,
And a rising speed of the ejector is the same as the rising speed of the surface of the injection liquid. 46. The method of claim 45,
In the step of injecting the injection liquid injection method after the injection of the injection is completed, the injection liquid remaining in the tip of the injection tube is sucked into the intermediate container. The method of claim 38, wherein
The syringe filling method includes a storage tank injection step of injecting injection liquid into a storage tank and an intermediate container storage step of transferring the injection liquid stored in the storage tank to an intermediate container,
The storage tank injection step includes the step of injecting the injection liquid into the storage tank, and putting the storage tank in the defoaming device to remove the bubbles contained in the injection liquid. 49. The method of claim 48 wherein
In the intermediate container storage step, the syringe filling method for pushing the piston installed in the storage tank to discharge the air located in the upper portion, and then move the injection liquid to the intermediate container The method of claim 38, wherein
The syringe filling method further comprises a microwave irradiation step of injecting microwaves into the injection liquid stored in the syringe after the injection liquid is injected into the syringe. The method of claim 38, wherein
Connecting the second negative pressure forming member installed at the tip of the stopper installer to the syringe filled with the injection liquid to discharge air inside the syringe; and inserting and installing the stopper into the syringe.

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