KR102377983B1 - Prefilled syringe filling apparatus - Google Patents

Abstract

The syringe filling device of the present invention includes an injection drug injection unit for injecting an injection solution into a syringe, and a rubber stopper inserting unit for inserting a rubber stopper after the injection solution is injected into the syringe corresponding to the syringe, the injection solution The injection unit forms a vacuum pressure in the syringe through a first vacuum line connected to the inside of the syringe.

Description

Syringe Filling Device {PREFILLED SYRINGE FILLING APPARATUS}

The present invention relates to a syringe filling device, and more particularly, to prevent the generation of particles that can enter the interior of the pre-filled syringe from the injection member and the nozzle for injecting the injection liquid, and to form a vacuum inside the pre-filled syringe It relates to a syringe filling device that improves the sealing performance of a vacuum line.

Conventionally, a method of storing an injection solution in an ampoule, inserting a syringe needle into the ampoule, sucking the injection solution from the ampoule with a syringe, and then injecting the injection solution into the living body using this syringe has been widely used.

However, since the ampoule is made of glass, when the ampoule is opened, the spout of the ampoule is broken and glass particles are frequently introduced into the inside of the ampoule, which has emerged as a social problem. And when injecting an injection into the ampoule, the injection was wasted because a larger amount of the injection was injected into the ampoule than is actually injected into the living body.

In order to solve the prevention of inflow of particles and wastage of the injectable liquid, a pre-filled syringe with a predetermined amount of the injectable liquid has been introduced. This pre-filled syringe not only serves to store the injectable liquid, but also plays a role in injecting the injectable liquid into the human body.

A prefilled syringe receives an injection liquid directly from an injection liquid storage tank, stores a set amount of injection liquid, and is stored and moved. The pre-filled syringe stores the injectable liquid and allows the injectable liquid to be directly injected into the body.

Therefore, the pre-filled syringe should not contain bubbles in the injection solution stored therein, and for this purpose, when injecting the injection solution into the pre-filled syringe, bubbles should not be generated inside the syringe.

One aspect of the present invention is a syringe that prevents the generation of particles that can enter the inside of the pre-filled syringe from the injection member and the nozzle for injecting the injectable solution, and increases the sealing performance of the vacuum line that forms a vacuum inside the pre-filled syringe To provide a charging device.

A syringe filling device according to an embodiment of the present invention includes an injection drug injection unit for injecting an injection solution into a syringe, and a rubber stopper inserting unit for inserting a rubber stopper after the injection solution is injected into the syringe corresponding to the syringe And, the injection drug injection unit forms a vacuum pressure in the syringe through a first vacuum line connected to the inside of the syringe.

The rubber stopper insert may form a vacuum pressure in the syringe through a second vacuum line connected to the inside of the syringe.

The injection liquid injection unit includes an injection member having a nozzle inserted into the syringe for injecting the injection liquid, and a first opening in which the injection member is mounted and the injection member is disposed. A first elevating plate for elevating, a first guide member disposed under the first elevating plate to guide the elevating of the injection member inserted therein, the first guide member is coupled to one side and the first guide member A first vacuum block to which the first holder is coupled to the opposite side, a first fixing plate having a second opening for fixing and supporting the first vacuum block and in which the first holder is disposed, and the syringe coupled to the first holder It may include a first vacuum bellows elastically sealed to the inlet of.

The injection member is inserted into the first guide member, the first vacuum block and the first holder to elevate, and the first vacuum line is the first vacuum passage connected to the inner vacuum passage in the first vacuum block. It may be connected between the guide member and the injection member, and between the injection member and the first holder.

The first guide member may be coupled to an upper side of the guide passage of the first vacuum block with a first seal interposed therebetween, and the first holder may be coupled to a lower side of the guide passage through a second seal.

The first guide member may further include a first spectra seal interposed between an upper end and an outer surface of the injection member, and a retainer configured to receive and fix the first spectra seal to the upper end.

The first holder may have a locking protrusion on an outer surface, and the first vacuum bellows may be coupled to the locking protrusion through a locking groove provided on the inner surface.

The first vacuum bellows may correspond to the inlet of the syringe and have elasticity in the vertical direction.

The first guide member may set a maximum range of lowering of the first elevating plate with respect to the upper surface of the first vacuum block.

The first guide member may set a maximum stroke at which the tip of the nozzle moves up and down in the syringe.

The injection member may be coupled to a first groove of the first elevating plate through which a first flange is provided on an upper outer surface, and the first flange may be fixed with a first cover installed on the first elevating plate. .

The first guide member is coupled to the second groove of the first vacuum block inserted and installed with a second flange on the outer surface of the lower portion, and the second flange is fixed with a second cover installed on the first vacuum block. can

The rubber stopper insert includes an insertion member having a rubber stopper inserted into the inlet of the syringe, and a second opening for mounting the insertion member and arranging the insertion member to lower the insertion member when the rubber stopper is inserted. A lifting plate, a second guide member disposed below the second lifting plate to guide the lifting and lowering of the insertion member inserted therein, the second guide member is coupled to one side and the second guide member is coupled to a second side opposite to the second guide member A second vacuum block to which the holder is coupled, a second fixing plate fixedly supporting the second vacuum block and having a second opening in which the second holder is disposed, and a second fixing plate coupled to the second holder and mounted on the inlet of the syringe and a second vacuum bellows that is sexually sealed.

The insertion member is inserted into the inside of the second guide member, the second vacuum block and the second holder to elevate, and the second vacuum line is the second vacuum line connected to the inner vacuum passage in the second vacuum block. It may be connected between the guide member and the insertion member, and between the insertion member and the second holder.

The second guide member may be coupled to the upper side of the guide passage of the second vacuum block with a first seal interposed therebetween, and the second holder may be coupled to the lower side of the guide passage with a second seal interposed therebetween.

The second guide member may further include a second spectra seal interposed between the upper end and the outer surface of the insertion member, and a retainer configured to receive and fix the second spectra seal to the upper end.

The second holder may have a locking protrusion on an outer surface, and the second vacuum bellows may be coupled to the locking protrusion through a locking groove provided on the inner surface.

As such, an embodiment of the present invention is provided with an injection drug injection unit and a rubber stopper insert, so that the injection chemical injection unit forms a vacuum pressure in the syringe through the first vacuum line connected to the inside of the syringe, so that it enters the inside of the syringe. It is possible to prevent the generation of possible particles.

In one embodiment, since the rubber stopper insert forms a vacuum pressure in the syringe through the second vacuum line connected to the inside of the syringe, it is possible to prevent the generation of particles that can enter the inside of the syringe.

In one embodiment, the injection member is inserted into the interior of the first guide member, the first vacuum block and the first holder to elevate, and the first vacuum block is connected to the internal vacuum passage between the first guide member and the injection member, injection Since a vacuum pressure is formed inside the syringe through the first vacuum line connected to the inside of the syringe and between the member and the first holder, the generation of particles that can enter the inside of the syringe from the injection member and the nozzle for injecting the injection liquid is prevented. can do.

In one embodiment, the first guide member is coupled to the upper side of the guide passage of the first vacuum block through the first seal, the first holder is coupled to the lower side of the guide passage through the second seal, the first guide member Since the upper end is installed as a first spectra sealing and retainer between the outer surfaces of the injection member, it is possible to increase the sealing performance of the first vacuum line forming a vacuum inside the syringe.

In one embodiment, the insertion member is inserted into the inside of the second guide member, the second vacuum block and the second holder to elevate, and the second vacuum block is inserted between the second guide member and the insertion member connected to the internal vacuum passage. Between the member and the second holder and through the second vacuum line connected to the inside of the syringe, a vacuum pressure is created inside the syringe, so that particles that can enter the inside of the syringe from the insertion member and the rubber stopper for inserting the rubber stopper are prevented. can be prevented

In one embodiment, the second guide member is coupled to the upper side of the guide passage of the second vacuum block through the first seal, the second holder is coupled to the lower side of the guide passage through the second seal, and the second guide member Since the upper end is installed as a second spectra sealing and retainer between the outer surface of the insertion member, the sealing performance of the second vacuum line forming a vacuum inside the syringe can be improved.

1 is a plan view showing a syringe filling device according to an embodiment of the present invention.
FIG. 2 is a right side view of FIG. 1 ;
FIG. 3 is a cross-sectional view of an injection drug injection unit taken along the line III-III of FIG. 1 .
FIG. 4 is a cross-sectional view showing the injection unit in which the first lifting plate operates upwardly during the process of filling the syringe with the injection solution starting from the state of FIG. 3 .
5 is a cross-sectional view illustrating the coupling state of the first spectra seal interposed in the vacuum passage formed between the outer surface of the injection member inserted into the first guide member and ascending and descending and the inner surface of one end of the first guide member.
6 is a cross-sectional view showing a sealing state of the inlet of the syringe with a first vacuum bellows coupled to the first vacuum block with a first holder interposed therebetween.
FIG. 7 is a cross-sectional view of a rubber stopper insertion part cut along line VII-VII of FIG. 1 .
8 is a cross-sectional view showing a rubber stopper insert in which the second lifting plate descends while inserting the rubber stopper into the syringe starting from the state of FIG. 7 .
9 is a cross-sectional view illustrating the coupling state of the second spectra seal interposed in the second vacuum passage formed between the outer surface of the insertion member inserted into the second guide member and ascending and descending and the inner surface of one end of the second guide member.
10 is a cross-sectional view showing a state before sealing the inlet of the syringe with a second vacuum bellows coupled to the second vacuum block with a second holder interposed therebetween.

Hereinafter, with reference to the accompanying drawings, the embodiments of the present invention will be described in detail so that those skilled in the art can easily carry out the present invention. However, the present invention may be embodied in several different forms and is not limited to the embodiments described herein. In order to clearly explain the present invention in the drawings, parts irrelevant to the description are omitted, and the same reference numerals are given to the same or similar components throughout the specification.

Terms including an ordinal number such as 1st, 2nd, etc. may be used to describe various elements, but the elements are not limited by the terms. The above terms are used only for the purpose of distinguishing one component from another.

When a component is referred to as being “connected” or “connected” to another component, it may be directly connected or connected to the other component, but it is understood that other components may exist in between. it should be On the other hand, when it is said that a certain element is "directly connected" or "directly connected" to another element, it should be understood that the other element does not exist in the middle.

Throughout the specification, terms such as “comprises” or “have” are intended to designate that a feature, number, step, operation, component, part, or combination thereof described in the specification is present, but one or more other features It should be understood that this does not preclude the existence or addition of numbers, steps, operations, components, parts, or combinations thereof. Therefore, when a part "includes" a component, it means that other components may be further included, rather than excluding other components, unless otherwise stated.

Figure 1 is a plan view showing a syringe filling device according to an embodiment of the present invention, Figure 2 is a right side view of Figure 1. The syringe filling device of one embodiment is a syringe (71, see FIGS. 3 and 4) inlet to seal the inlet of the injectable liquid injection unit 100 for injecting the injectable liquid into the syringe and the corresponding injectable liquid is injected into the syringe 71. It includes a rubber stopper insert 200 for inserting the rubber stopper (81, see FIGS. 7 and 8).

The injectable liquid injection unit 100 injects the injectable liquid into the supplied pre-filled syringe 71 , and the rubber stopper insert 200 inserts the rubber stopper 81 into the injectable 71 into which the injectable liquid is injected. The injectable drug injection unit 100 and the rubber stopper insertion unit 200 are operated independently of each other in relation to each other.

To this end, although not shown, the syringe 71 may be moved from the injection unit 100 to the rubber stopper insertion unit 200 by a separate driving device. An empty syringe 71 is newly supplied to the injection liquid injection unit 100, and the syringe 71 into which the injection liquid is injected from the injection medicine injection unit 100 is moved to the rubber stopper insertion unit 200, and the rubber stopper After the inlet is sealed in the insertion part 200, it is discharged.

The injection drug injection unit 100 forms a vacuum pressure inside the syringe 71 through a first vacuum line VL1 (see FIGS. 3 and 4 ) connected to the inside of the syringe 71 . The rubber stopper insert 200 forms a vacuum pressure inside the syringe 71 through the second vacuum line VL2 (refer to FIGS. 7 and 8 ) connected to the inside of the syringe 71 .

While the syringe 71 is filled with the injection solution, the injection unit 100 creates a vacuum pressure inside the syringe 71, and then moves to insert the rubber stopper 81 into the syringe 71 inlet (Fig. The vacuum pressure inside the syringe 71 is released when moving back and forth in 1 and moving left and right in FIG. 2). The rubber stopper insertion unit 200 forms a vacuum pressure inside the syringe 71 again to insert the rubber stopper 81 after the vacuum is released.

Figure 3 is a cross-sectional view of the injection liquid injection unit cut along the line III-III of Figure 1, Figure 4 is the injection in which the first lifting plate operates upward during the process of filling the injection liquid into the syringe starting from the state of Figure 3; It is a cross-sectional view showing the chemical liquid injection part.

1 to 4 , in the syringe filling device of an embodiment, the injection unit 100 includes an injection member 10 having a nozzle 11 , and a first elevating plate having a first opening 201 . 20 , a first guide member 30 , a first vacuum block 40 , a first fixing plate 50 having a second opening 51 , and a first vacuum bellows 60 .

The nozzle 11 is inserted into the pre-filled syringe (hereinafter, referred to as "syringe") 71 to inject the injectable solution into the syringe 71 . To this end, the injection member 10 coupled to the nozzle 11 is integrally lifted and lowered, and the injection member 10 is connected to receive the injection liquid from the injection liquid storage tank (not shown).

The injection member 10 is disposed above, and the nozzle 11 extends downward of the injection member 10 . Accordingly, the upper opening of the injection member 10 is connected to the storage tank, and the nozzle 11 is inserted or withdrawn into the syringe 71 .

Before injecting the injection solution into the syringe 71, the nozzle 11 is deeply inserted to the lowest set inside the syringe 71, and while injecting the injection solution into the syringe 71, it rises at a speed corresponding to the injection speed. .

Therefore, the injection liquid injected from the inside of the syringe 71 does not scatter, and bubbles are not generated, so that the injection liquid filled in the syringe 71 does not contain bubbles.

To this end, the first elevating plate 20 is equipped with an injection member 10 and provided with a first opening 201 at a portion where the injection member 10 is disposed, thereby injecting an injection solution into the syringe 71 . It is configured to raise the injection member 10 in accordance with the rate at which the level of the chemical solution rises as the drug solution is lowered and then filled inside when injected. At this time, the outer surface of the nozzle 11 is exposed to the inner space of the syringe 71, but does not come into contact with the injection liquid, and the end of the nozzle 11 maintains a constant distance from the liquid level.

As an example, the first lifting plate 20 may further include a first mounting member 22 . The first mounting member 22 is fixedly installed on the upper surface of the first elevating plate 20 by a fastening member 23 . And the first mounting member 22 is provided with a first mounting hole 221 for mounting the injection member (10). When there are a plurality of injection members 10 , the first mounting member 22 includes a plurality of first mounting holes 221 to facilitate mounting of the injection members 10 .

The injection member 10 is provided with a first flange 101 on the outer surface of the upper portion and is installed to penetrate the first mounting member 22 of the first elevating plate 20, and is formed on the first mounting member 22. The first groove 222 is coupled to the first flange 101 .

The first flange 101 is fixed by the first cover 24 installed on the first mounting member 22 of the first elevating plate 20 . The first groove 222 is formed by further extending the first mounting hole 221 to accommodate the first flange 101 . That is, the first cover 24 penetrates the upper end of the injection member 10 and presses the upper surface of the first flange 101 . The first cover 24 is fastened to the first mounting member 22 with a fastening member 23 , and may be fastened with a separate fastening member (not shown).

The injection members 10 mounted on the first mounting member 22 penetrate the first opening 201 of the first lifting plate 20 and maintain a state extending downward of the first lifting plate 20 . . The first elevating plate 20 and the first mounting member 22 are connected to be elevated by a driving means (not shown).

The first guide member 30 is spaced apart from the lower side of the first lifting plate 20 to guide the lifting of the injection member 10 inserted therein. According to the operation of the first lifting plate 20 and the first mounting member 22 , the first guide member 30 is maintained in a fixed state corresponding to the injection member 10 . The first gap G1 between the first elevating plate 20 and the first guide member 30 is increased or decreased according to the elevating of the first elevating plate 20 .

That is, FIG. 3 shows the minimum first interval G1, and FIG. 4 shows the increased first interval G1. In this way, the first guide member 30 sets the maximum range of descending of the first lifting plate 20 with respect to the upper surface of the first vacuum block 40 . That is, the first guide member 30 sets the maximum stroke at which the tip of the nozzle 11 moves up and down in the syringe 71 . Accordingly, the nozzle 11 is not separated from the upper end of the first guide member 30 and does not touch the bottom of the syringe 71 .

In the first vacuum block 40 , the first guide member 30 is coupled to one side, and the first holder 61 is coupled to the opposite side of the first guide member 30 . The first vacuum block 40 maintains a fixed state against the lifting operation of the first lifting plate 20 .

To this end, the first fixing plate 50 fixes and supports the first vacuum block 40 with the fastening member 52 , and has a second opening 51 in which the first holder 61 is disposed. That is, the first vacuum block 40 is fixed on the first fixing plate 50 , and the first guide member 30 is mounted on the upper side of the first vacuum block 40 , and the A first holder 61 is mounted on the lower side.

The first vacuum bellows 60 is coupled to the first holder 61 and elastically sealed to the inlet of the syringe 71 . The first vacuum bellows 60 corresponds to the inlet of the syringe 71 and has elasticity in the vertical direction.

The injection member 10 is inserted into the inside of the first guide member 30, the first vacuum block 40 and the first holder 61 to elevate, and the first vacuum block 40 is a vacuum passage 401 inside. ) between the first guide member 30 and the injection member 10, between the injection member 10 and the first holder 61, and the first vacuum line VL1 connected to the inside of the syringe 71 create a vacuum in

The first guide member 30 is coupled to the upper side of the guide passage 402 penetrating through the first vacuum block 40 in the vertical direction with the first sealing S1 interposed therebetween, and the first holder 61 is guided It is coupled to the lower side of the passage 402 via the second sealing (S2).

That is, the first sealing S1 seals one side of the first vacuum line VL1 between the inner surface of the guide passage 402 and the outer surface of the first guide member 30 . The second seal S2 seals the other side of the first vacuum line VL1 between the inner surface of the guide passage 402 and the outer surface of the first holder 61 .

In this way, since a vacuum pressure is formed in the connected first vacuum line VL1, it is possible to prevent the generation of particles that can enter the inside of the syringe 71 from the injection member 10 and the nozzle 11 for injecting the injection liquid. can

5 is a cross-sectional view illustrating the coupling state of the first spectra seal interposed in the vacuum passage formed between the outer surface of the injection member inserted into the first guide member and ascending and descending and the inner surface of one end of the first guide member.

3 to 6, the first guide member 30 is a first spectra sealing (301) interposed between the upper end and the outer surface of the injection member (10), and the first spectra sealing (301) It further includes a retainer 302 for receiving and fixing to the top. The retainer 302 is coupled to the coupling groove 303 of the first guide member 30 by a projection 304 to limit the axial movement of the first spectra sealing 301 .

In addition, while the retainer 302 limits the axial movement of the first spectra seal 301 , the first spectra seal 301 moves in a radial direction between the outer surface of the injection member 10 and the inner surface of the first guide member 30 . to have elasticity.

That is, since the first spectra sealing 301 expands the sealing member 312 provided on the outside by the expansion force of the elastic member 311 provided therein, even if time passes and the sealing member 312 is worn, the first It is possible to continuously seal the inner surface of the guide member 30 and the outer surface of the injection member 10 .

In one embodiment, the first guide member 30 is coupled to the upper side of the guide passage 402 of the first vacuum block 40 with a first seal S1 interposed therebetween, and the first holder 61 is the guide passage 402 ) is coupled through the second seal S2 to the lower side, and the upper end of the first guide member 30 is installed between the outer surface of the injection member 10 as the first spectra seal 301 and the retainer 302. The sealing performance of the first vacuum line VL1 for forming a vacuum inside the syringe 71 may be improved.

6 is a cross-sectional view showing a sealing state of the inlet of the syringe with a first vacuum bellows coupled to the first vacuum block with a first holder interposed therebetween. 3, 4 and 6, the first holder 61 is provided with a locking projection 611 on the outer surface, the first vacuum bellows 60 is a locking projection with a locking groove 601 provided on the inner surface. (611) is coupled.

At this time, the syringe 71 may be installed and supported in the syringe holder 72 , and the inlet of the syringe 71 and the first vacuum bellows 60 may be in close contact with each other by the ascending force of the syringe holder 72 . In this way, since the first vacuum bellows 60 covers the inlet of the syringe 71, the inflow of particles into the syringe 71 can be prevented.

In addition, the first vacuum bellows 60 covering the inlet of the syringe 71 is vacuum inside the syringe 71 together with the first spectra sealing 301 provided in the first guide member 30 and the injection member 10 . It is possible to further increase the sealing performance of the first vacuum line VL forming the .

On the other hand, the first guide member 30 is coupled to the second groove 405 of the first vacuum block 40 is inserted and installed with a second flange 305 on the outer surface of the lower portion, the second flange 305 is It is fixed with the second cover 44 installed on the first vacuum block 40 .

The second groove 405 is formed by further extending the guide passage 402 to receive the second flange 305 . That is, the second cover 44 presses the upper surface of the second flange 305 while penetrating the first guide member 30 . The second cover 44 may be fastened to the first vacuum block 40 with a fastening member 52 or may be fastened with a separate fastening member (not shown).

And the first vacuum block 40 is provided with a guide passage (402). When there are a plurality of injection members 10, the first vacuum block 40 is provided with a plurality of guide passages 402 to enable the lifting and lowering of the injection members 10, and the plurality of injection members 10 and A vacuum pressure may be effectively applied to the plurality of first vacuum lines VL1 formed between the first guide members 30 .

7 is a cross-sectional view of the rubber stopper insertion part cut along the line VII-VII of FIG. 1, and FIG. 8 is a rubber stopper in which the second lifting plate descends while inserting the rubber stopper into the syringe starting from the state of FIG. It is a cross-sectional view showing the insertion part.

1, 2, 7 and 8, in the syringe filling device of an embodiment, the rubber stopper insert 200 includes an insertion member 210 having a rubber stopper 81, the first opening 211 A second lifting plate 220 having a second guide member 230, a second vacuum block 240, a second fixing plate 250 having a second opening 251, and a second vacuum bellows ( 260).

The rubber stopper 81 is inserted into the inlet after filling the syringe 71 with the drug solution to seal the syringe 71 . To this end, the insert member 210 coupled with the rubber stopper 81 is integrally lifted and lowered, and the rubber stopper 81 is supplied from the rubber stopper supply unit (not shown).

The insertion member 210 is disposed above and descends to the inlet of the syringe 71 into which the injection liquid is injected, inserts the rubber stopper 81, and then rises to receive the rubber stopper 81 for the next process.

To this end, the second elevating plate 220 is equipped with an insertion member 210 and provided with a first opening 211 at a portion where the insertion member 210 is disposed, and a rubber stopper ( When inserting the 81), it is descended and the rubber stopper 81 is inserted into the inlet and then the insertion member 210 is raised.

As an example, the second lifting plate 220 may further include a second mounting member 422 . The second mounting member 422 is fixedly installed on the upper surface of the second elevating plate 220 as a fastening member 223 . And the second mounting member 422 is for mounting of the insertion member (210).

A second mounting hole 321 is provided. When there are a plurality of insertion members 210 , the second mounting member 422 includes a plurality of second mounting holes 321 to facilitate mounting of the insertion members 210 .

The insertion member 210 is installed through the first opening 211 of the second elevating plate 220 , and is coupled to the second mounting hole 321 formed in the second mounting member 422 with a difference in diameter. That is, the second mounting member 422 passes through the upper end of the insertion member 210 and presses the upper surface of the insertion member 210 by a difference in diameter. The second mounting member 422 is fastened to the second elevating plate 220 by a fastening member 223 .

The insertion members 210 mounted on the second mounting member 422 penetrate the first opening 211 of the second lifting plate 220 and maintain a state extending downward of the second lifting plate 220 . . The second elevating plate 220 and the second mounting member 422 are connected to be elevated by a driving means (not shown).

The second guide member 230 is spaced apart from the lower side of the second lifting plate 220 to guide the lifting of the insertion member 210 inserted therein. According to the operation of the second lifting plate 220 and the second mounting member 422 , the second guide member 230 is maintained in a fixed state corresponding to the insertion member 210 . The second gap G2 between the second elevating plate 220 and the second guide member 230 is increased or decreased according to the elevating of the second elevating plate 220 .

That is, FIG. 7 shows the second interval G2 just before loading the rubber stopper 81 into the insertion member 210 and inserting it into the inlet of the syringe 71, and FIG. 8 is the second interval G2 that is reduced. represents In this way, the second guide member 230 sets the maximum range of lowering of the second elevating plate 220 with respect to the upper surface of the second vacuum block 240 . That is, the second guide member 230 sets the maximum stroke that the rubber stopper 81 inserts into the inlet of the syringe 71 . However, the rubber stopper 81 is not separated from the lower end of the insertion members 210 and operates within a range that is not excessively inserted into the syringe 71 .

In the second vacuum block 240 , the second guide member 230 is coupled to one side, and the second holder 261 is coupled to the opposite side of the second guide member 230 . The second vacuum block 240 maintains a fixed state against the lifting operation of the second lifting plate 220 .

To this end, the second fixing plate 250 fixes and supports the second vacuum block 240 with the fastening member 252 , and has a second opening 251 in which the second holder 261 is disposed. That is, the second vacuum block 240 is fixed on the second fixing plate 250 , the second guide member 230 is mounted on the upper side of the second vacuum block 240 , and the second vacuum block 240 is A second holder 261 is mounted on the lower side.

The second vacuum bellows 260 is coupled to the second holder 261 and elastically sealed to the inlet of the syringe 71 . The second vacuum bellows 260 corresponds to the inlet of the syringe 71 and has elasticity in the vertical direction.

The insertion member 210 is inserted into the inside of the second guide member 230, the second vacuum block 240 and the second holder 261 to elevate, and the second vacuum block 240 is a vacuum passage 401 inside. ) between the second guide member 230 and the insertion member 210, between the insertion member 210 and the second holder 261, and a second vacuum line (VL2) connected to the inside of the syringe 71 create a vacuum in

The second guide member 230 is coupled to the upper side of the guide passage 402 penetrating through the second vacuum block 240 in the vertical direction with the first sealing S1 interposed therebetween, and the second holder 261 is the guide It is coupled to the lower side of the passage 402 via the second sealing (S2).

That is, the first sealing S1 seals one side of the second vacuum line VL2 between the inner surface of the guide passage 402 and the outer surface of the second guide member 230 . The second sealing S2 seals the other side of the second vacuum line VL2 between the inner surface of the guide passage 402 and the outer surface of the second holder 261 .

In this way, since a vacuum pressure is formed in the connected second vacuum line VL2, it is possible to prevent the generation of particles that can enter the inside of the syringe 71 from the insertion member 210 for inserting the rubber stopper 81. .

9 is a cross-sectional view showing the coupling state of the second spectra seal interposed in the second vacuum passage formed between the outer surface of the lifting member inserted into the second guide member and ascending and descending and the inner surface of one end of the second guide member.

7 to 9, the second guide member 230 is a second spectra sealing (421), and a second spectra sealing (421) interposed between the upper end and the outer surface of the insertion member (20). It further includes a retainer 302 for receiving and fixing to the top. The retainer 302 is coupled to the coupling groove 303 of the second guide member 230 through the projection 304 to limit the axial movement of the second spectra sealing 421 .

In addition, the retainer 302 restricts the axial movement of the second spectra seal 421 and the second spectra seal 421 is positioned between the outer surface of the insertion member 210 and the inner surface of the second guide member 230 in the radial direction. to have elasticity.

That is, the second spectra sealing 421 expands the sealing member 412 provided on the outside by the expansion force of the elastic member 411 provided therein. The inner surface of the guide member 230 and the outer surface of the insertion member 210 may be continuously sealed.

In one embodiment, the second guide member 230 is coupled to the upper side of the guide passage 402 of the second vacuum block 240 with the first sealing S1 interposed therebetween, and the second holder 261 is the guide passage 402 . ) is coupled through the second sealing S2 to the lower side, and the upper end of the second guide member 230 is installed between the outer surface of the insertion member 210 as a second spectra sealing 421 and a retainer 302. The sealing performance of the second vacuum line VL2 that forms a vacuum inside the syringe 71 may be improved.

10 is a cross-sectional view showing a state before sealing the inlet of the syringe with a second vacuum bellows coupled to the second vacuum block with a second holder interposed therebetween. 7, 9 and 10, the second holder 261 is provided with a locking protrusion 611 on the outer surface, the second vacuum bellows 260 is a locking protrusion with a locking groove 601 provided on the inner surface. (611) is coupled.

At this time, the syringe 71 may be installed and supported in the syringe holder 72 , and the inlet of the syringe 71 and the second vacuum bellows 260 may be in close contact with each other by the ascending force of the syringe holder 72 . In this way, since the second vacuum bellows 260 covers the inlet of the syringe 71, the inflow of particles into the syringe 71 can be prevented.

In addition, the second vacuum bellows 260 covering the inlet of the syringe 71 is vacuum inside the syringe 71 together with the second spectra sealing 421 provided on the second guide member 230 and the insertion member 210 . It is possible to further increase the sealing performance of the second vacuum line VL2 forming the .

On the other hand, the second guide member 230 is coupled to the second groove 405 of the second vacuum block 240 inserted and installed by having a second flange 305 on the outer surface of the lower portion, and the second flange 305 is It is fixed by the second cover 44 installed on the second vacuum block 240 .

The second groove 405 is formed by further extending the guide passage 402 to receive the second flange 305 . That is, the second cover 44 presses the upper surface of the second flange 305 while penetrating the second guide member 230 . The second cover 44 may be fastened to the second vacuum block 240 with a fastening member 252 or may be fastened with a separate fastening member (not shown).

And the second vacuum block 240 is provided with a guide passage (402). When there are a plurality of insertion members 210, the second vacuum block 240 includes a plurality of guide passages 402 to enable the lifting and lowering of the insertion members 210, and the plurality of insertion members 210 and A vacuum pressure may be effectively applied to the plurality of second vacuum lines VL2 formed between the second guide members 230 .

Although preferred embodiments of the present invention have been described above, the present invention is not limited thereto, and it is possible to carry out various modifications within the scope of the claims, the detailed description of the invention, and the accompanying drawings, and this also It is natural to fall within the scope of

11: nozzle 10: injection member
20, 220: first and second elevating plates 22, 422: first and second mounting members
23, 223: fastening member 24, 44: first, second cover
30, 230: first and second guide members 40, 240: first and second vacuum blocks
50, 250: first and second fixing plates 51, 251: second opening
52, 252: fastening member 60, 260: first, second vacuum bellows
61, 261: first, second holder 71: syringe
72: syringe holder 101, 305: first, second flange
201, 211: first opening 210: insertion member
221, 321: first, second mounting hole 222: first groove
301: first spectra sealing 302: retainer
303: coupling groove 304: projection
311: elastic member 312: sealing member
401: vacuum passage 402: guide passage
405: second groove 421: second spectra sealing
601: jamming groove 611: jamming projection
G1, G2: 1st, 2nd interval S1, S2: 1st, 2nd sealing
VL1, VL2: 1st, 2nd vacuum line

Claims (17)

an injection liquid injection unit for injecting an injection liquid into a syringe; and a rubber stopper insert for inserting a rubber stopper after the injection solution is injected into the syringe corresponding to the syringe,
The injection drug injection unit forms a vacuum pressure in the syringe through a first vacuum line connected to the inside of the syringe,
The injection drug injection unit,
An injection member having a nozzle inserted into the syringe to inject the injection solution,
A first elevating plate for mounting the injection member and having a first opening in which the injection member is disposed to elevate the injection member when injecting the drug solution;
A first guide member disposed below the first lifting plate to guide the lifting and lowering of the injection member inserted therein;
a first vacuum block to which the first guide member is coupled to one side and a first holder is coupled to an opposite side of the first guide member, and
and a first fixing plate for fixing and supporting the first vacuum block and having a second opening in which the first holder is disposed,
The first guide member
A syringe filling device for setting a maximum stroke at which the tip of the nozzle ascends and descends within the syringe. According to claim 1,
The rubber stopper insert
A syringe filling device for forming a vacuum pressure in the syringe through a second vacuum line connected to the inside of the syringe. According to claim 1,
The injection drug injection unit,
The syringe filling device further comprising a first vacuum bellows coupled to the first holder and elastically sealed to the inlet of the syringe. 4. The method of claim 3,
The injection member is
It is inserted into the first guide member, the first vacuum block and the first holder to elevate,
The first vacuum line is
Between the first guide member and the injection member connected to the internal vacuum passage in the first vacuum block, and
between the injection member and the first holder
Syringe filling device connected to. 5. The method of claim 4,
The first guide member is coupled to the upper side of the guide passage of the first vacuum block with a first sealing interposed therebetween,
The first holder is a syringe filling device coupled to the lower side of the guide passage with a second sealing interposed therebetween. 6. The method of claim 5,
The first guide member
A first spectra sealing interposed between the upper end and the outer surface of the injection member, and
The syringe filling device further comprising a retainer for accommodating the first spectra sealing and fixing to the upper end. 7. The method of claim 6,
The first holder is provided with a locking projection on the outer surface,
The first vacuum bellows is a syringe filling device coupled to the locking projection with a locking groove provided on the inner surface. 8. The method of claim 7,
The first vacuum bellows
A syringe filling device corresponding to the inlet of the syringe and having elasticity in the vertical direction. 4. The method of claim 3,
The first guide member
A syringe filling device for setting the maximum range of descending of the first lifting plate with respect to the upper surface of the first vacuum block. delete 4. The method of claim 3,
The injection member is coupled to the first groove of the first elevating plate through which the first flange is provided on the outer surface of the upper portion,
The first flange is a syringe filling device fixed to the first cover installed on the first lifting plate. 4. The method of claim 3,
The first guide member is coupled to the second groove of the first vacuum block inserted and installed with a second flange on the outer surface of the lower portion,
The second flange is a syringe filling device fixed to a second cover installed on the first vacuum block. 3. The method of claim 2,
The rubber stopper insertion part,
An insertion member having a rubber stopper inserted into the inlet of the syringe;
a second elevating plate for mounting the inserting member and having a second opening in which the inserting member is disposed to lower the inserting member when the rubber stopper is inserted;
a second guide member disposed below the second elevation plate to guide the elevation of the insertion member inserted therein;
a second vacuum block to which the second guide member is coupled to one side and a second holder is coupled to an opposite side of the second guide member;
a second fixing plate fixing and supporting the second vacuum block and having a second opening in which the second holder is disposed; and
A second vacuum bellows coupled to the second holder and elastically sealed to the inlet of the syringe
A syringe filling device comprising a. 14. The method of claim 13,
The insert member is
It is inserted into the second guide member, the second vacuum block and the second holder to elevate,
The second vacuum line is
Between the second guide member and the insertion member connected to the internal vacuum passage in the second vacuum block, and
between the insertion member and the second holder
connected to
syringe filling device. 15. The method of claim 14,
The second guide member is coupled to the upper side of the guide passage of the second vacuum block with a first sealing interposed therebetween,
The second holder is coupled to the lower side of the guide passage with a second sealing interposed therebetween.
syringe filling device. 16. The method of claim 15,
The second guide member
a second spectra sealing interposed between the upper end and the outer surface of the insert member; and
The syringe filling device further comprising a retainer for accommodating the second spectra sealing and fixing it to the top. 17. The method of claim 16,
The second holder is provided with a locking projection on the outer surface,
The second vacuum bellows is a syringe filling device coupled to the locking projection with a locking groove provided on the inner surface.

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