KR20120083900A - 케모카인 수용체 활성의 조절제로서의 피페리디닐 유도체의 전구약물 - Google Patents
케모카인 수용체 활성의 조절제로서의 피페리디닐 유도체의 전구약물 Download PDFInfo
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Classifications
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
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| US24927009P | 2009-10-07 | 2009-10-07 | |
| US61/249,270 | 2009-10-07 |
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| KR20120083900A true KR20120083900A (ko) | 2012-07-26 |
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| AR106018A1 (es) * | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| EP3340983B1 (en) | 2015-08-26 | 2023-10-04 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
| EP3589287B1 (en) | 2017-03-01 | 2022-09-14 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for treatment of medical disorders |
| CN110776481B (zh) * | 2018-07-24 | 2023-06-16 | 四川大学华西医院 | 一类双阳离子化合物及其制备方法和用途 |
| CN108727248B (zh) * | 2018-07-25 | 2021-05-25 | 四川大学华西医院 | 一类双季铵化合物及其制备方法和用途 |
| JP7471300B2 (ja) | 2018-12-17 | 2024-04-19 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 補体介在性疾患を治療するための的を絞った投与 |
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| US7601844B2 (en) * | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
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| JP5292400B2 (ja) | 2007-07-24 | 2013-09-18 | ブリストル−マイヤーズ スクイブ カンパニー | ケモカイン受容体活性のモジュレーターとしてのピペリジン誘導体 |
| CN101808991A (zh) | 2007-07-24 | 2010-08-18 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的哌啶基衍生物 |
| TWI433838B (zh) * | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
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| PE20121109A1 (es) | 2012-08-20 |
| US20110082113A1 (en) | 2011-04-07 |
| CL2012000882A1 (es) | 2012-09-07 |
| US8410139B2 (en) | 2013-04-02 |
| AU2010303441A1 (en) | 2012-05-03 |
| EP2486013B1 (en) | 2015-07-08 |
| CN102648179B (zh) | 2015-06-17 |
| MX2012003656A (es) | 2012-04-30 |
| EA022150B1 (ru) | 2015-11-30 |
| WO2011044309A1 (en) | 2011-04-14 |
| CA2777032A1 (en) | 2011-04-14 |
| JP5788397B2 (ja) | 2015-09-30 |
| US20130178444A1 (en) | 2013-07-11 |
| NZ599261A (en) | 2013-10-25 |
| EA201270468A1 (ru) | 2012-11-30 |
| EP2486013A1 (en) | 2012-08-15 |
| AR078543A1 (es) | 2011-11-16 |
| CO6440510A2 (es) | 2012-05-15 |
| CN102648179A (zh) | 2012-08-22 |
| IL219122A0 (en) | 2012-06-28 |
| BR112012007755A2 (pt) | 2015-09-15 |
| JP2013507377A (ja) | 2013-03-04 |
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