KR20120083767A - Skin material for external use comprising juice and extraction of onion - Google Patents

Skin material for external use comprising juice and extraction of onion Download PDF

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KR20120083767A
KR20120083767A KR1020110005097A KR20110005097A KR20120083767A KR 20120083767 A KR20120083767 A KR 20120083767A KR 1020110005097 A KR1020110005097 A KR 1020110005097A KR 20110005097 A KR20110005097 A KR 20110005097A KR 20120083767 A KR20120083767 A KR 20120083767A
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skin
onion
extract
juice
external use
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하홍열
문광성
김도형
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하홍열
김도형
문광성
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Vascular Medicine (AREA)
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Abstract

PURPOSE: An external use skin formulation containing onion skin juice, extract, or powder is provided to effectively protect skin from UV ray and to lighten skin tone. CONSTITUTION: An external use skin formulation contains onion skin juice, extract, or powder as an active ingredient. The external use skin formulation further contains lactic acid fermentation of onion skin juice or extract. The lactic acid bacteria include Lactobacillus rhamnosus, Lactobacillus plantarum, Bacillus Kasei, or Bifidobacterium lactis. An external use skin formulation is manufactured in the form of emulsions, lotions, creams, soludions, suspensions, hydrous products(oil and glycols), gel, mask, pack, and powder.

Description

양파피 착즙액, 추출물, 또는 분말을 함유한 피부외용제{SKIN MATERIAL FOR EXTERNAL USE COMPRISING JUICE AND EXTRACTION OF ONION}Skin external preparation containing onion skin juice, extract, or powder {SKIN MATERIAL FOR EXTERNAL USE COMPRISING JUICE AND EXTRACTION OF ONION}

본 발명은 양파피 착즙액, 추출물, 또는 분말을 함유한 피부외용제에 관한 것으로, 보다 상세하게는 양파피 착즙액, 추출물, 또는 분말을 함유한 피부외용제는 피부보호활성, 특히 자외선에 대한 피부보호활성이 우수하고, 또 피부를 윤기 있고 밝게 해주는 효과가 우수하며, 아울러 지방산패효과와 함께 혈관을 강화하여 고혈압이나 동맥경화를 예방하는 효과도 우수한 피부외용제에 관한 것이다.The present invention relates to an external skin preparation containing onion skin juice, extract, or powder, and more particularly, the external skin preparation containing onion skin juice, extract, or powder protects the skin, particularly skin protection against ultraviolet rays. Excellent activity, the skin shine and brightening effect is excellent, and also with the fatty acid plaque effect and strengthen the blood vessels to prevent high blood pressure or arteriosclerosis is also excellent external skin preparations.

양파는 백합과에 속하는 채소로 약용성분이 많고 향신료로서 독특한 향과 매운맛으로 예부터 조리시에 널리 사용되어 왔다. 또한 독특한 매운 맛을 내는 함황화합물과 함께 항균성, 항산화성, 혈압강하, 혈전용해능, 항통풍성 및 중금속 제거능 등 다양한 생리기능적 특성을 가지는 것으로 밝혀져 있다.Onion is a vegetable belonging to the family Liliaceae, has many medicinal ingredients and has been widely used in cooking since ancient times for its unique aroma and spicy taste. In addition, it has been found to have various physiological functional characteristics such as antibacterial, antioxidant, blood pressure lowering, thrombolytic activity, anti-gout property and heavy metal removal ability, along with a unique pungent sulfur compound.

종래 양파를 이용한 다양한 식품조리방법 내지 가공방법 등이 개발되어 왔으나, 양파의 껍질을 제거한 양파속만을 재료로 사용하고 양파피는 주로 음식물 쓰레기로 분리하여 폐기처분하는 것이 일반적이다.Conventionally, various food cooking methods or processing methods using onions have been developed, but it is common to use only onion genus from which onion skins are removed, and onion blood is usually disposed of as food waste.

하지만 양파피와 이와 함께 버려지는 양파속에는 여전히 유용한 항산화물질이 다량 함유되어 있음에도 전량 폐기처분되어지고 있음은 심각한 자원의 낭비이자 폐기물 처리에 따른 추가적인 비용이 수반되어지는 등의 경제적 손실도 초래한다.However, the onion skin and the onions that are thrown away with it still contain large amounts of useful antioxidants, but are discarded entirely, resulting in economic losses such as a significant waste of resources and additional costs associated with waste disposal.

이에 따라 자원의 재활용적인 측면과 국민생활건강의 증진을 도모하고 양파재배 농가 및 관련 산업기술의 발전을 함께 도모하기 위한 차원에서라도 양파피에 대한 재활용방안이 시급히 연구되어져야 한다. Therefore, the method of recycling onion skin should be urgently investigated in order to promote the recycling of resources, the improvement of people's health, and the development of onion-cultivated farmers and related industrial technologies.

본 발명은 상기한 바와 같이 종래기술이 가지는 문제를 해결하기 위해 제안된 것으로, The present invention has been proposed to solve the problems of the prior art as described above,

그 목적은 양파피를 재활용하는 방안의 일환으로 피부보호활성, 특히 자외선에 대한 피부보호활성이 우수하고, 또 피부를 윤기 있고 밝게 해주는 효과가 우수하며, 아울러 지방산패효과와 함께 혈관을 강화하여 고혈압이나 동맥경화를 예방하는 효과가 우수한 피부외용제를 제공함에 있다.Its purpose is to recycle onion skin, and it has excellent skin protection activity, especially skin protection against UV rays, and makes skin shine and bright, and also strengthens blood vessels with fatty acid loss effect. In addition, the present invention provides an excellent external skin preparation for preventing atherosclerosis.

상기한 바와 같은 본 발명의 기술적 과제는 다음과 같은 수단에 의해 달성되어진다.The technical problem of the present invention as described above is achieved by the following means.

(1) 양파피 착즙액, 추출물, 또는 분말을 활성물질로 함유하는 피부외용제.(1) An external preparation for skin containing onion blood juice, extract, or powder as an active substance.

(2) 제 1항에 있어서,(2) The method according to claim 1,

양파피는 팽화처리한 것임을 특징으로 하는 피부외용제.Onion skin is a skin external preparation, characterized in that the puffed treatment.

(3) 제 2항에 있어서, (3) The method according to 2,

팽화처리는 양파피를 2 내지 5㎏/㎠하에서 90~110℃에서 2~5분간 퍼핑하는 과정에 의해 수행된 것을 특징으로 하는 피부외용제. Puffing treatment is an external skin preparation, characterized in that the onion blood was carried out by the process of puffing for 2 to 5 minutes at 90 ~ 110 ℃ under 2 to 5kg / ㎠.

(4) 제 1항에 있어서, (4) The method according to 1,

활성물질은 0.01 내지 20 중량% 첨가되는 것을 특징으로 하는 피부외용제.The external preparation for skin, wherein the active substance is added in an amount of 0.01 to 20% by weight.

(5) 제 1항에 있어서, (5) The method according to claim 1,

양파피 착즙액 또는 추출물의 유산균 발효물을 더 포함하는 것을 특징으로 하는 피부외용제.The external preparation for skin, characterized in that it further comprises lactic acid bacteria fermentation of onion blood juice or extract.

(6) 제 5항에 있어서, (6) the method of paragraph 5,

유산균은 락토바실러스 람노서스, 락토바실러스 플란타럼, 락트바실러스 카제이, 및 비피도박테리움 락티스에서 선택되어지는 1종 혹은 2종 이상인 것을 특징으로 하는 피부외용제. Lactobacillus is a skin external preparation, characterized in that one or two or more selected from Lactobacillus rhamnosus, Lactobacillus plantarum, Lactbacillus casei, and Bifidobacterium lactis.

본 발명에 의한 양파피 착즙액, 추출물, 또는 분말을 활성물질을 함유한 피부외용제는 피부보호활성, 특히 자외선에 대한 피부보호활성이 우수하고, 또 피부를 윤기 있고 밝게 해주는 효과가 우수하고, 더욱이 양파피 착즙액, 추출물, 또는 분말에 함유된 각종 항산화물질들은 지방산패효과와 함께 혈관을 강화하여 고혈압이나 동맥경화를 예방하는 효과도 제공한다. Onion skin juice, extract, or powder according to the present invention, the skin external preparation containing the active substance is excellent in skin protection activity, in particular, the skin protection activity against ultraviolet rays, it is also excellent in the effect to make the skin shiny and bright, moreover Various antioxidants contained in onion blood juices, extracts, or powders provide fatty acid plaque effects and strengthen blood vessels to prevent hypertension and atherosclerosis.

본 발명은 양파피 착즙액, 추출물, 또는 분말을 활성물질로 함유하는 피부외용제를 제공한다.The present invention provides an external preparation for skin containing onion blood juice, extract, or powder as an active substance.

본 발명에서 양파피는 양파의 껍질을 말하며, 상기 양파의 순수 껍질 이외에 이와 접한 최외층 양파속을 포함할 수도 있다. 바람직하게는 최외층 양파속을 포함하는 양파피가 사용되며 이는 실제 양파의 전처리 현장에서 양파피만을 제거하는 것이 쉽지 않아 최외층 양파속을 포함하여 함께 제거하는 경우가 많기 때문에 이를 재활용하고 또 양파피와는 다른 양파속에 함유된 다양한 항산화물질을 더 이용할 수 있다는 점에서 특히 권장된다.Onion blood refers to the skin of the onion in the present invention, in addition to the pure skin of the onion may include the outermost onion genus in contact with this. Preferably, the onion skin containing the outermost onion genus is used, which is not easy to remove only the onion skin at the actual pretreatment site of the onion, so it is often removed together, including the outermost onion genus, and the onion blood It is especially recommended in that different antioxidants are available in different onion genus.

본 발명에서는 양파피가 쿼세틴과 같은 플라보노이드가 풍부하고 기타 다양한 항산화물질을 함유하고 있는 것으로 알려져 피부외용제의 활성성분으로 활용할 수 있는 가능성을 알아보았다. 본 발명에 의하면 양파피 착즙액 및 추출물을 함유한 피부외용제는 피부보호활성, 특히 자외선에 대한 피부보호활성이 우수하고, 또 피부를 윤기 있고 밝게 해주는 효과가 우수하다. 더욱이 양파피 착즙액 내지 추출물에 함유된 각종 항산화물질들은 지방산패효과와 함께 혈관을 강화하여 고혈압이나 동맥경화를 예방하는 효과도 제공한다.In the present invention, onion blood is known to be rich in flavonoids such as quercetin and other various antioxidants, and found out the possibility of using it as an active ingredient for skin external preparations. According to the present invention, the skin external preparations containing the extract of onion skin juice and extract have excellent skin protection activity, in particular, the skin protection activity against ultraviolet rays, and the effect of making the skin shiny and bright. In addition, various antioxidants contained in the extracts of onion blood juices provide fatty acid plaque effects and strengthen blood vessels to prevent hypertension or arteriosclerosis.

본 발명에 따른 양파피의 착즙액은 공지의 착즙기를 이용하여 착즙하면 충분하고, 추출물은 열수추출물, 에탄올 추출물 또는 물과 에탄올의 혼합물을 이용한 추출물, 또는 초임계추출물을 포함한다. 열수 추출물의 경우 1?10배의 물을 가하여 1 내지 2기압, 80?120℃하에 1?12시간 추출하는 것이 바람직하다. 에탄올 추출물의 경우 50 내지 100% 에탄올로 이루어진 추출용매를 이용할 수 있고, 초임계 추출물은 에탄올을 추출용매로 하여 250 내지 350bar의 압력하에 수행되어질 수 있다.The juice of onion blood according to the present invention is sufficient to juice using a known juicer, the extract includes a hot water extract, an ethanol extract or an extract using a mixture of water and ethanol, or supercritical extract. In the case of hot water extract, it is preferable to add 1 to 10 times of water and extract for 1 to 12 hours under 1 to 2 atmospheres and 80 to 120 ° C. In the case of the ethanol extract, an extraction solvent consisting of 50 to 100% ethanol may be used, and the supercritical extract may be performed under a pressure of 250 to 350 bar using ethanol as the extraction solvent.

상기 양파피, 이의 착즙액 혹은 추출물은 통상적인 동결건조처리과정을 통해 동결건조분말의 형태로 사용되어질 수 있다. 이러한 과정은 공지된 방법에 따라 수행되어질 수 있으므로 상세한 설명은 생략하기로 한다.The onion blood, juice or extract thereof may be used in the form of lyophilized powder through a conventional freeze-drying process. Since this process may be performed according to a known method, a detailed description thereof will be omitted.

또한, 본 발명에서 상기 양파피의 추출물 혹은 이의 동결처리분말은 양파의 매운향을 제거하고 항산화물질의 흡수를 촉진시키기 위해 양파피를 팽화처리한 것을 원료로 이용하는 것이 바람직하다. 양파피의 팽화처리는 원료인 양파피를 2 내지 5㎏/㎠하에서 90~110℃에서 2~5분간 퍼핑하는 과정을 통해 얻어질 수 있다. In addition, in the present invention, the extract of onion peel or frozen powder thereof is preferably used as a raw material to swell the onion blood in order to remove the spicy flavor of the onion and promote the absorption of antioxidants. Puffed onion skin may be obtained through the process of puffing the onion skin as a raw material for 2 to 5 minutes at 90 ~ 110 ℃ under 2 to 5kg / ㎠.

상기 본 발명에 따른 피부외용제는 전체 조성물 중량을 기준으로 할 때 양파피 착즙액, 추출물, 또는 분말을 0.01 내지 20 중량%로 사용함으로써 자외선 보호효과 및 피부미용효과에 탁월하며, 만일 0.001 중량% 미만일 경우에는 자외선 보호효과 및 피부미용효과가 미약한 문제점이 있고, 20 중량% 초과하면 제형화의 어려움과 피부 부작용의 문제가 우려된다. The skin external preparation according to the present invention is excellent in the ultraviolet protection effect and skin beauty effect by using the onion skin juice, extract, or powder in an amount of 0.01 to 20% by weight based on the total composition weight, and if less than 0.001% by weight In this case, there is a problem that the UV protection effect and the skin beauty effect is weak, and if it exceeds 20% by weight, the difficulty of formulation and the problem of skin side effects.

또한, 본 발명에서는 상기 양파피 착즙액 또는 추출물과 함께 이들에 유산균을 접종하여 발효시킨 유산균 발효물을 더욱 포함하는 것이 바람직하다. 상기 유산균 발효물의 경우 양파피(또는 양파속의 일부를 포함하여)가 갖는 피부보호활성을 더욱 보강할 뿐만 아니라 면역활성이 높아 특히 어린이나 노약자에게도 적합한 특징이 있다. 이러한 유산균발효물은 락토바실러스 람노서스, 락토바실러스 플란타럼, 락트바실러스 카제이, 및 비피도박테리움 락티스에서 선택되어지는 1종 혹은 2종 이상을 사용할 수 있고, 바람직하게는 상기 4종의 혼합균을 이용하여 상기 발효대상인 양파피의 착즙액 또는 추출물의 중량대비 0.1 내지 3 중량% 첨가하여 35 내지 40 ℃에서 1 내지 7일간 발효시킨 것을 사용할 수 있다. In addition, the present invention preferably further comprises a lactic acid bacteria fermented product inoculated with lactic acid bacteria and fermented with the onion blood juice or extract. In the case of the lactic acid bacteria fermented product not only reinforces the skin protective activity of onion skin (or including a part of the onion genus) but also has high immunity and is particularly suitable for children or the elderly. The lactic acid bacterium fermentation product may be used one or two or more selected from Lactobacillus rhamnosus, Lactobacillus plantarum, Lactbacillus casei, and Bifidobacterium lactis, preferably four kinds By using the mixed bacteria 0.1 to 3% by weight relative to the weight of the juice solution or extract of the onion blood to be fermented can be used for 1 to 7 days at 35 to 40 ℃.

상기 본 발명에 따른 양파피 착즙액, 추출물, 또는 분말을 함유하는 피부외용제는 다양한 형태로 제조될 수 있으며, 예를 들어, 에멀젼, 로션, 크림(수중유적형, 유중수적형, 다중상), 용액, 현탁액(무수 및 수계), 무수 생성물(오일 및 글리콜계), 젤, 마스크, 팩, 분말 등의 제형으로 제조될 수 있다. Onion skin juice containing extracts, extracts, or powders according to the present invention can be prepared in various forms, for example, emulsions, lotions, creams (oil-in-water, water-in-oil, multiphase), It can be prepared in the form of solutions, suspensions (anhydrous and aqueous), anhydrous products (oil and glycols), gels, masks, packs, powders and the like.

본 발명의 피부보호를 위한 피부외용제는 상기 양파피 착즙액, 추출물, 또는 분말 이외에 피부외용제의 제형에 있어서 통상적으로 사용될 수 있는 담체를 포함할 수 있다. 이러한 담체의 예로서는 알코올, 오일, 계면활성제, 지방산, 실리콘 오일, 습윤제, 보습제, 점성 변형제, 유제, 방부제, 안정제, 자외선 차단제, 발색제, 향료 등을 들 수 있다. 상기 담체는 본 발명의 피부외용제 전체 중량에 대하여 약 0.5 중량% 내지 약 99.99 중량%, 바람직하게는 조성물의 중량의 약 80 중량% 내지 약 99.99 중량%로 포함될 수 있다. The external skin preparation for skin protection of the present invention may include a carrier that can be used in the formulation of the external skin preparation in addition to the onion skin juice, extract, or powder. Examples of such carriers include alcohols, oils, surfactants, fatty acids, silicone oils, wetting agents, humectants, viscosity modifiers, emulsions, preservatives, stabilizers, sunscreens, colorants, fragrances and the like. The carrier may be included from about 0.5% to about 99.99% by weight, preferably from about 80% to about 99.99% by weight of the composition, based on the total weight of the external preparation for skin of the present invention.

또한 본 발명에 따른 피부보호효과를 가지는 피부외용제는 통상적인 사용방법에 따라 사용될 수 있으며, 사용자의 피부 상태 또는 취향에 따라 그 사용횟수를 달리할 수 있다.In addition, the skin external preparation having a skin protection effect according to the present invention may be used according to a conventional method of use, and the number of times of use may vary depending on the skin condition or taste of the user.

이하 본 발명의 내용을 실시예에 의해 보다 구체적으로 설명하기로 한다. 다만 이들 실시예 및 실험예는 본 발명의 이해를 위해 예시되는 것일 뿐 본 발명의 권리범위를 제한하지는 아니함을 유의해야 한다.
Hereinafter, the content of the present invention will be described in more detail with reference to Examples. However, it should be noted that these Examples and Experimental Examples are only illustrated for the understanding of the present invention and do not limit the scope of the present invention.

[실시예 1] 스킨로션의 제조Example 1 Preparation of Skin Lotion

하기 표 1의 처방에 따라 공지된 방법에 의해 피부 외용 연고를 제조하였다.To the skin ointment was prepared by a known method according to the prescription of Table 1.

조성물Composition 중량%weight% 샘플1Sample 1 샘플2Sample 2 양파 착즙액Onion Juice 1010 -- 양파추출물Onion Extract -- 1010 디에틸 세바케이트Diethyl sebacate 88 88 경납Prepayment 55 55 폴리옥시에틸렌올레일에테르포스페이트Polyoxyethylene Oleyl Ether Phosphate 66 66 벤조산 나트륨Sodium benzoate 적량Suitable amount 적량Suitable amount 바셀린vaseline to 100to 100 to 100to 100

[실시예 2] 크림의 제조Example 2 Preparation of Cream

하기 표 2의 처방에 따라 공지된 방법에 의해 크림을 제조하였다. 다만 샘플2에 사용된 양파추출물은 팽화처리한 양파피의 열수추출물로 하였다.To prepare a cream by a known method according to the prescription of Table 2. However, the onion extract used in Sample 2 was a hot water extract of the expanded onion skin.

조성물Composition 중량%weight% 샘플1Sample 1 샘플2Sample 2 양파 착즙액Onion Juice 1010 -- 양파추출물Onion Extract -- 1010 스테아린산Stearic acid 1515 1515 세탄올Cetanol 1One 1One 수산화칼륨Potassium hydroxide 0.70.7 0.70.7 글리세린glycerin 55 55 프로필렌글리콜Propylene glycol 33 33 방부제antiseptic 적량Suitable amount 적량Suitable amount incense 적량Suitable amount 적량Suitable amount 정제수Purified water to 100to 100 to 100to 100

[실시예 3] [Example 3]

하기 표 3의 처방에 따라 공지된 방법에 의해 팩을 제조하였다. The pack was prepared by a known method according to the formulation of Table 3 below.

조성물Composition 중량%weight% 샘플1Sample 1 샘플2Sample 2 양파 착즙액Onion Juice 1010 -- 양파추출물Onion Extract -- 1010 글리세린glycerin 55 55 프로필렌글리콜Propylene glycol 44 44 폴리비닐알코올Polyvinyl alcohol 1515 1515 에탄올ethanol 88 88 폴리옥시에틸렌올레일에틸Polyoxyethylene oleylethyl 1One 1One 파라옥시안식향산메틸Methyl paraoxybenzoate 0.20.2 0.20.2 색소Pigment 적량Suitable amount 적량Suitable amount incense 적량Suitable amount 적량Suitable amount 정제수Purified water to 100to 100 to 100to 100

[실험예 1] 스킨 로션의 피부 자극성 및 보호 효과 확인Experimental Example 1 Check the skin irritation and protective effect of skin lotion

건강한 성인 남녀 20명(남자 10명, 여자 10명)의 전박부에 상기 실시예 1에서 제조한 스킨 로션을 일정량(10m/5㎠)씩 도포하고, 그 외의 부위를 알루미늄 호일로 차폐하여 30분 후에, 자외선 조사기를 이용하여 장파장 자외선을 10.2J/㎠ 의 용량으로 조사하고 24시간 후에 피부 상태(홍반, 부종, 구진 등)를 관찰하였다. 관찰 결과 피부에 홍반 등의 부작용이 발생되지 않아 상기 스킨 로션은 광독성이 없으며 피부 보호 효과가 있음을 확인할 수 있었다.
Apply the skin lotion prepared in Example 1 (10m / 5cm2) to the forearm of 20 healthy males and females (10 males, 10 females) and shield the rest with aluminum foil for 30 minutes. Subsequently, long wavelength ultraviolet rays were irradiated at a dose of 10.2 J / cm 2 using an ultraviolet irradiator, and skin conditions (erythema, edema, papules, etc.) were observed after 24 hours. As a result, skin side effects such as erythema do not occur on the skin, and thus the skin lotion has no phototoxicity and has a skin protection effect.

[실험예 2] 크림의 피부 자극성 및 보호 효과 확인Experimental Example 2 Confirmation of Skin Irritant and Protective Effect of Cream

건강한 성인 남녀 20명(남자 10명, 여자 10명)의 전박부에 상기 실시예 2에서 제조한 크림을 일정량(10m/5㎠)씩 도포하고, 그 외의 부위를 알루미늄 호일로 차폐하여 30분 후에, 자외선 조사기를 이용하여 장파장 자외선을 10.2J/㎠ 의 용량으로 조사하고 24시간 후에 피부 상태(홍반, 부종, 구진 등)를 관찰하였다. 관찰 결과 피부에 홍반 등의 부작용이 발생되지 않아 상기 크림은 광독성이 없으며 피부 보호 효과가 있음을 확인할 수 있었다.
Apply the cream prepared in Example 2 to the forearm of 20 healthy males and females (10 males, 10 females) by a predetermined amount (10 m / 5 cm 2), and shield the rest with aluminum foil for 30 minutes. Long-wavelength ultraviolet rays were irradiated at a dose of 10.2 J / cm 2 using an ultraviolet irradiator and skin conditions (erythema, edema, papules, etc.) were observed after 24 hours. As a result of the observation, the side effects such as erythema did not occur on the skin, and thus the cream did not have phototoxicity and it could be confirmed that the skin protective effect.

[실험예 3] 스킨 로션 및 크림의 피부 안정성 확인 시험Experimental Example 3 Skin Stability Test of Skin Lotion and Cream

건강한 성인 남녀 20명(남자 10명, 여자 10명)의 전박부에 상기 실시예 1과 2에서 제조한 스킨 로션 및 크림을 이용하여 인체 첩포 시험을 실시하였다. 시험대상자의 전박부를 70% 에탄올로 잘 닦은 다음 그 부위에, 통상의 화장료 기제에 상기 실시예 2와 3에서 제조한 스킨 로션 및 크림을 20㎕씩 담은 핀 챔버를 점착 테이프를 이용하여 24시간 폐쇄 부착시켰다. 24시간 후에 점착 테이프와 핀 챔버를 제거하고, 가제로 피부에 잔존된 시료를 가볍게 닦아 제거한 뒤에 피부 상태를 관찰하고 다시 24시간 후에 한번 더 관찰하였다. 실험 결과 본 발명에 따른 스킨 로션 및 크림의 피부 자극성을 확인하기 위한 인체 첩포 시험에서 양성반응을 보이지 않아 인체 피부에 자극성이 전혀 없는 것으로 확인되었다.
A human patch test was carried out on the forearm of 20 healthy adult men and women (10 males, 10 females) using the skin lotions and creams prepared in Examples 1 and 2 above. Wipe the forearm of the subject well with 70% ethanol, and then close the pin chamber containing 20 μl of the skin lotion and cream prepared in Examples 2 and 3 on a conventional cosmetic base using adhesive tape for 24 hours. Attached. After 24 hours, the adhesive tape and the pin chamber were removed, and the sample remaining on the skin with a gauze was lightly removed, and then the skin condition was observed, and again after 24 hours. As a result of the experiment, the skin patch test for confirming the skin irritation of the skin lotion and cream according to the present invention did not show a positive reaction, and thus it was confirmed that there is no irritation on the human skin.

상기와 같이, 본 발명의 바람직한 실시 예를 참조하여 설명하였지만 해당 기술 분야의 숙련된 당업자라면 하기의 특허청구범위에 기재된 본 발명의 사상 및 영역으로부터 벗어나지 않는 범위 내에서 본 발명을 다양하게 수정 및 변경시킬 수 있음을 이해할 수 있을 것이다.While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims. It can be understood that

Claims (6)

양파피 착즙액, 추출물, 또는 분말을 활성물질로 함유하는 피부외용제.Skin external preparation containing onion blood juice, extract, or powder as an active substance. 제 1항에 있어서,
양파피는 팽화처리한 것임을 특징으로 하는 피부외용제.
The method of claim 1,
Onion skin is a skin external preparation, characterized in that the puffed treatment.
제 2항에 있어서,
팽화처리는 양파피를 2 내지 5㎏/㎠하에서 90~110℃에서 2~5분간 퍼핑하는 과정에 의해 수행된 것을 특징으로 하는 피부외용제.
The method of claim 2,
Puffing treatment is an external skin preparation, characterized in that the onion blood was carried out by the process of puffing for 2 to 5 minutes at 90 ~ 110 ℃ under 2 to 5kg / ㎠.
제 1항에 있어서,
활성물질은 0.01 내지 20 중량% 첨가되는 것을 특징으로 하는 피부외용제.
The method of claim 1,
The external preparation for skin, wherein the active substance is added in an amount of 0.01 to 20% by weight.
제 1항에 있어서,
양파피 착즙액 또는 추출물의 유산균 발효물을 더 포함하는 것을 특징으로 하는 피부외용제.
The method of claim 1,
The external preparation for skin, characterized in that it further comprises lactic acid bacteria fermentation of onion blood juice or extract.
제 5항에 있어서,
유산균은 락토바실러스 람노서스, 락토바실러스 플란타럼, 락트바실러스 카제이, 및 비피도박테리움 락티스에서 선택되어지는 1종 혹은 2종 이상인 것을 특징으로 하는 피부외용제.
6. The method of claim 5,
Lactobacillus is a skin external preparation, characterized in that one or two or more selected from Lactobacillus rhamnosus, Lactobacillus plantarum, Lactbacillus casei, and Bifidobacterium lactis.
KR1020110005097A 2011-01-18 2011-01-18 Skin material for external use comprising juice and extraction of onion KR20120083767A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160110325A (en) 2016-09-05 2016-09-21 무안군 Composition for prevention and treatment of male infertility
KR20200095433A (en) * 2020-07-23 2020-08-14 (주)제니트리 composition for preventing and alleviating ultraviolet-induced skin damage and cosmetic comprising the same
KR20200095432A (en) * 2020-07-23 2020-08-14 (주)제니트리 composition for preventing and alleviating laser-induced skin damage and cosmetic comprising the same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160110325A (en) 2016-09-05 2016-09-21 무안군 Composition for prevention and treatment of male infertility
KR20200095433A (en) * 2020-07-23 2020-08-14 (주)제니트리 composition for preventing and alleviating ultraviolet-induced skin damage and cosmetic comprising the same
KR20200095432A (en) * 2020-07-23 2020-08-14 (주)제니트리 composition for preventing and alleviating laser-induced skin damage and cosmetic comprising the same

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