KR20120057744A - Cosmetic composition contained metal nano particle with various active for propere iontophoresis - Google Patents

Abstract

PURPOSE: A cosmetic composition with enhanced transdermal absorption effect is provided to enhance whitening, anti-wrinkling, and elasticity. CONSTITUTION: A cosmetic composition for enhancing transdermal absorption effect contains metal complex as an active ingredient. The metal complex includes gold(Au), silver(Ag), iron(Fe), cobalt(Co), nickel(Ni), chrome(Cr), manganese(Mn), barium(Ba), strontium(Sr), titanium(Ti), zirconium(Zr), platinum(Pt), palladium(Pd), or ruthenium(Ru). The cosmetic composition is manufactured in the form of a lotion, toner, essence, cream, gel, pack, sun cream, massage cream, foundation, and makeup base.

Description

Cosmetics containing various active ingredients combined with metal nanoparticles suitable for iontophoresis {COSMETIC COMPOSITION CONTAINED METAL NANO PARTICLE WITH VARIOUS ACTIVE FOR PROPERE IONTOPHORESIS}

The present invention relates to a cosmetic containing an active ingredient combined with metal ion particles, the use of which relates to its composition as a cosmetic suitable for iontophoresis in a beauty device.

Nanoparticles are particles having at least one dimension of 100 nm or less. In other words, it is a particle belonging to the field of nanotechnology that manipulates molecules or atoms to make new materials, structures, machines, mechanisms, devices, and studies the structure. The materials in these states, despite their identical chemical composition, exhibit very different optical and electromagnetic properties from the bulk due to their rapidly increasing specific surface area and quantum mechanical effects.

In the case of the metal nanopowder, if the size of the powder is continuously reduced, the powder becomes unstable due to an increase in surface energy due to an increase in specific surface area. Since the degree of activity varies depending on the type of metal, there is a difference in the limit size, but the size of spontaneous ignition is about 1 μm. Even if it is not spontaneously ignited, it is not stable because the surface is oxidized continuously when stored in the air. Therefore, various studies have been made regarding the method for producing metal nanoparticles.

Currently used methods for producing metal nanoparticles can be divided into physical manufacturing methods and chemical synthesis methods. Physical processes include gas condensation, which is produced through homogenous nucleation and condensation in the gas phase, and mechanical pulverization, where the bulk metal is pulverized and nanoscaled. However, especially in the case of the mechanical grinding method, there is a limitation in the size of the particles to be crushed, and the biggest disadvantage is that the particle size distribution and the size of the particles are large. In addition, it requires a lot of energy and equipment cost to crush the particles, but the amount produced is very small.

In the case of chemical synthesis, the most commonly used method can be classified into gas phase reaction, liquid phase reaction, and solid phase reaction according to the reaction region. In the chemical reaction, the energy accompanying the reaction can be utilized, so that the synthesis is possible with a small amount of energy input, and the speed of the synthesis reaction can be controlled quickly and uniformly. However, despite these advantages, there is a problem that it is difficult to remove impurities. The largest impurity can be called a reducing agent. In the process of removing the reducing agent from the reduced nanoparticle solution, the reducing agent is not certainly removed, and the process is very complicated. In addition, it is necessary to disperse the nanoparticles again in the solvent after the removal of impurities, this process is also not complete, may cause precipitation phenomenon.

In order to solve the above problems, a metal nanoparticle manufacturing method using an electron beam has recently been used. In the case of using the electron beam, the electron beam itself may provide the reducing energy, and thus it is not necessary to use a separate reducing agent. Therefore, there is no impurities such as a reducing agent harmful to the human body can be an environmentally friendly manufacturing method.

A method of manufacturing a nanomaterial using an electron beam is disclosed in Korean Patent No. 10-0782133, which is a method of irradiating an electron beam to a sample in a solid state or powder state. However, there was a problem that the yield is small and the size and distribution of the produced particles are uneven. Before irradiating an electron beam, a process of purifying a compound in a solvent is required to make a powder, which makes the process complicated and cannot be easily mass-produced. In addition, in order to commercialize a sample in a solid state it is necessary to disperse in a solvent after the nanoparticles are generated by irradiation with an electron beam, due to technical difficulties there is a problem that the nanoparticles are not uniformly dispersed in the solvent because of the dispersion.

In the case of making nanoparticles by chemical reaction or electron beam, they are ionized when the particles become nanoscale, so it is necessary to stabilize them immediately when they are left to be aggregated. The material was used as its dispersant.

Thus, the combination of the nanoparticles and the active ingredient may create synergistic effects on their own. The present invention further studies a method of promoting percutaneous absorption into the skin by electrical repulsion using the electric charges they have.

The ion introduction management method in the field of skin beauty is a management method that absorbs the active ingredients of water-soluble cosmetics such as gels, ampoules and essences that are difficult to penetrate the skin using ions using DC current. Ion implantation penetrates deeper than externalizing ions. Since Le Duc published a study in 1903 that chemicals can pass through a membrane by direct current, the penetration of chemicals into the human body has emerged as a method of electrotherapy and for diagnostic purposes. . In 1946, Abramowitsch D and Neoussikine B created the purpose of iontophoresis treatment using new machines, drugs and methods. Recently, in dermatology, otolaryngology, ophthalmology, dentistry, urology, gynecology oncology and other fields are constantly attempting to introduce new drugs using iontophoresis, it is also used in the field of skin care.

 The skin is relatively incompatible with water and cannot enter or exit through epithelial tissue. Therefore, electrolytes dissolved in other solutions can penetrate the skin, but since electrolytes dissolved in water cannot diffuse through the skin, the membrane of epithelial tissue composed of proteins and lipids is electrically neutral.

In order for a compound to penetrate into cell membranes such as epithelial tissues, it must have both ideal, fat-soluble and hydrophilic properties. Hydrophilic or polar factors are needed to ionize the solution and fat soluble or nonpolar factors are needed for tissue penetration of the ions. When penetrating tissues, hydrogen bonds must be broken at the same time to pass through fatty layers such as hydroxyl (OH) or carboxyl groups (Carboxy, COOH), which requires low kinetic energy. At this time, molecules with the fewest number of hydroxyl groups (OH) pass best through fat. All nonpolar groups, such as the methyl group (Methyl group CH3) and the ethyl group (Ethyl group C2H5), must be released from the fat as the molecules pass through the water. Molecules with a small number of methyl groups (CH3) are less likely to penetrate because of less resistance in water.

Therefore, the ideal compound used for iontophoresis should be a compound having a high lipid-water partition coefficient and a balanced polar-nonpolarity with less hydroxyl (OH) and methyl (CH3). .

The sweat duct of the skin is the main passage of ions. However, pores such as the stratum corneum, hair follicle, and sebaceous gland of the skin have high electrical impedance, resulting in poor overall ion transport but positive charges below pH 3 and negative charges above pH 4. Most of the solutions used for iontophoresis are pH 4 or higher, so the skin is negatively charged, causing ions to move in the pores. The penetration depth of ions due to electric current is 1 mm or less and usually penetrates to dermis. However, they penetrate deeper into capillary circulation and membrane transport.

 The amount of material ions penetrated into the tissue by ion introduction is determined by the intensity and density of the current and the concentration of the ions. Although it can be applied according to various skin conditions, accurate diagnosis and analysis of the applied area should be preceded. Used for the purpose of hydration, moisturizing, regenerative effect, skin irritation, and sensitive skin. The electrodes to be used include tweezers electrodes, roller electrodes, mask electrodes and the like.

The effect is different depending on the electrode, but the effect on the negative electrode is 1) sodium hydroxide, or alkali, can open pores to break down sebum and exfoliate the surface layer of the skin, resulting in a smooth and clean skin. 2) Temporarily softens the skin because the solution is driven. The flushing of the skin and the swelling of blood vessels increase blood circulation, which promotes the supply of nutrients and oxygen and removes impurities to promote skin tone and skin condition. 4) Promotes cell metabolism and improves skin condition. 5) Alkaline sodium hydroxide can be corrected by destroying acid mantal, changing skin pH, or changing polarity for 2-4 minutes after treatment. The effect at the anode is 1) the acid mantal is restored by the formation of hydrochloric acid. 2) Acid makes skin hard. 3) The tissue fluid is far from the anode. 4) Vasodilation or flushing hardly occurs. 5) Activate the organization.

The present invention improves the performance of the cosmetics, which were difficult to transdermal absorption by combining the metal nanoparticles and iontophresis mentioned above to provide a cosmetic formulation that maximizes skin penetration when using a beauty device.

According to an aspect of the present invention for achieving the above object, the step of adding a metal precursor and a surfactant to the solvent and stirring, injecting the mixture or complex compound produced in the stirring step into the receiving container and receiving in the injection step Irradiating an electron beam to the mixture or complex compound injected into the container.

Preferably the metal precursor is a metal salt or a mixture of two or more metal salts, the metal is gold (Au), silver (Ag), iron (Fe), cobalt (Co), nickel (Ni), chromium (Cr), manganese (Mn), barium (Ba), strontium (Sr), titanium (Ti), zirconium (Zr), platinum (Pt), palladium (Pd), and ruthenium (Ru).

Preferably the active ingredient may be a high molecular compound or a natural surfactant.

Preferably, the active ingredient is a hydrocarbon containing at least one functional group, and the hydrocarbon is a C1 to C20 alkanethiol, an alkanethiol derivative, and a di-thiol and tri-thiol compound including a mercapto group (-SH). At least one selected from the group consisting of one or more selected from a hydroxyl group (-OH), a benzyl group (-C6H5), a nitro group (-NO2), a carboxylic acid group (-COOH), and a phosphonic acid group (-H3PO4) It may be one selected from the group consisting of compounds containing an alkyl group of C1 to C20 having a substituent.

Preferably, the functional group is carbonyl group (-CO), ether group (-O-), ester group (-COO), nitro group (-NO ₂ ), amino group (-NH ₄ ), sulfonic acid group (-SO ₃ H) , Mercapto group (-SH), carboxylic acid group (-COOH), phosphonic acid group (-H ₃ PO ₄ ), hydroxy group (-OH), benzyl group (-C ₆ H ₅ ), and aldehyde group (- CHO).

Preferably, the molar ratio of the metal precursor and the surfactant may range from 1: 0.1 to 1: 100.

Preferably the pH of the mixture or complex may be 3 to 11.

Preferably, the material of the container is plastic, the total thickness when the mixture or complex compound is contained in the container may be 0.1 ~ 40 cm.

Preferably, the solvent may be any one selected from alcohols, glycol solvents, water, and mixtures of two or more thereof.

According to another aspect of the present invention, the cosmetic preparation containing a component combined with the metal ion, lotion, essence, cream, eye cream, gel, foundation, BB cream, makeup base, sunscreen cosmetics.

The present invention relates to a cosmetic containing an active ingredient combined with metal ion particles, it is possible to significantly improve the transdermal absorption in the skin by the method of ion introduction. The composition for a cosmetic device of the present invention has an effect on both whitening and wrinkle improvement, elasticity

It will be described in detail according to a preferred embodiment of the present invention.

 [Example]

5.0 wt%, Glycerin 4.0 wt%, Hyaluronic acid 5.0 wt%, Betaglucan 7.0 wt%, Carbomer 0.1% wt%, Caprylic capric triglyceride 8.0 wt%, Squalane 5.0 wt%, Cetearyl glucoside 1.5% wt %, Sorbitan stearate 0.4% by weight, cetaleyl alcohol 1.0% by weight, preservatives, fragrance, pigment, triethanol amine 0.1% by weight, the balance of purified water was uniformly mixed to prepare a cosmetic composition. In detail, the cosmetic composition is first prepared by mixing 4.0% by weight of glycerin, 15.0% by weight of polyvinyl alcohol, 5.0% by weight of hyaluronic acid extract, 7.0% by weight of betaglucan, and 0.1% by weight of carbomer and heating to 70 ° C. After dissolving, 5% by weight of the metal ion complex prepared above was added thereto and stirred for 10 minutes with a homomixer, followed by 1.5% by weight of cetearyl glucoside, 0.4% by weight of sorbitan stearate, and cetearyl alcohol. 1.0% by weight, a suitable amount of preservative, a proper amount of aroma, a suitable amount of dye and triethanolamine by adding 0.1% by weight of the homomixer was made to stir to evenly dispersed for 15 to 20 minutes at 1,000 ~ 5,000 rpm.

[Comparative Example]

The cosmetic composition prepared as a comparative example is a cosmetic composition that does not contain a metal ion complex. The preparation method is the same as in <Example>, but purified water was further added instead of the cluster powder.

[Experimental Example] Experiment of Skin Improvement Effect

Experimental Example 1 Measurement of the Whitening Effect Index

In this experiment, the cosmetic whitening effect index of <Example> was prepared.

Experimental method Chromameter CR-400 equipment was applied to 14 adult men and women with healthy skin after 2 weeks 4 weeks 8 weeks after applying the cosmetic composition 2mg / cm2 of the above <Example> using an iontophoretic beauty device The change in L * value of the pigmented site was measured and evaluated.

 L * value measurement result by Chromameter CR-400 No. name Test Product (A) 0wk 4wk 8wk One KMJ 59.32 59.99 60.69 2 KGJ 61.32 61.69 62.21 3 KYS 62.87 63.13 62.33 4 KJS 61.62 60.07 61.37 5 KJH 58.84 60.04 61.63 6 KCS 60.81 61.61 61.66 7 SBK 62.57 64.46 64.74 8 SEY 62.71 62.87 62.93 9 SEK 57.92 58.70 58.52 10 OYO 60.01 60.63 61.49 11 LMY 61.14 61.80 62.59 12 LJS 59.52 61.37 62.43 13 JYM 62.23 62.26 63.03 14 HWH 62.22 61.66 63.08 Average 60.94 61.45 62.05 Standard Deviation 1.58 1.49 1.42

Example: Result of L * value change before and after use No. name Test Product (A) △ L * ? L * ₁ ? L * ₂ One KMJ 0.68 1.37 2 KGJ 0.37 0.90 3 KYS 0.26 -0.55 4 KJS -1.55 -0.26 5 KJH 1.19 2.79 6 KCS 0.81 0.85 7 SBK 1.89 2.17 8 SEY 0.16 0.22 9 SEK 0.78 0.60 10 OYO 0.62 1.47 11 LMY 0.66 1.45 12 LJS 1.86 2.92 13 JYM 0.03 0.80 14 HWH -0.56 0.87 Average 0.51 1.11 Standard Deviation 0.89 1.02

From the results of <Table 1> and <Table 2>, it can be seen that the whitening effect of the composition of <Example> is excellent. This shows that the metal ion complexes included as active ingredients in the composition of <Example> have a whitening effect.

Experimental Example 2 Measurement of Wrinkle Improvement

In this experiment, the wrinkle improvement effect index of the cosmetic composition of <Example> and the cosmetic composition of <Comparative Example> was tested.

The experimental method was applied to 15 adult men and women with healthy skin using the iontophoretic beauty device with the cosmetic composition 2mg / cm2 of the above <Example> after 2 weeks, 4 weeks, 8 weeks after using the mock plate Image analysis was performed using a Viscometer (Skin-Viscometer SV 600, Courage & Khazaka Germany).

Imaging results of copying plate before using the product No. Subject Test product (left eye corner) R1 R2 R3 R4 R5 One KJJ 0.60 0.44 0.30 0.24 0.08 2 SYJ 0.42 0.35 0.23 0.13 0.05 3 SHS 0.55 0.40 0.29 0.22 0.07 4 YHS 0.64 0.47 0.28 0.25 0.08 5 LDK 0.35 0.27 0.19 0.13 0.05 6 LEK 0.53 0.45 0.29 0.16 0.06 7 LCH 0.70 0.59 0.37 0.22 0.08 8 HSS 0.58 0.46 0.31 0.21 0.07 No. Subject Test product (right eye) R1 R2 R3 R4 R5 9 GHO 0.48 0.40 0.25 0.14 0.05 10 KHY 0.61 0.48 0.28 0.20 0.07 11 SOJ 0.50 0.44 0.30 0.13 0.06 12 OYH 0.65 0.45 0.31 0.24 0.10 13 LYJ 0.59 0.48 0.30 0.17 0.07 14 JEM 0.61 0.50 0.33 0.20 0.07 15 JJH 0.59 0.37 0.25 0.26 0.10 Average 0.560 0.437 0.359 0.285 0.071 Standard Deviation 0.092 0.074 0.097 0.043 0.016

4 weeks after using the product No. Subject Test product (left eye corner) R1 R2 R3 R4 R5 One KJJ 0.47 0.34 0.23 0.20 0.06 2 SYJ 0.40 0.35 0.20 0.12 0.04 3 SHS 0.51 0.39 0.27 0.19 0.07 4 YHS 0.55 0.39 0.25 0.21 0.08 5 LDK 0.34 0.28 0.18 0.11 0.04 6 LEK 0.65 0.40 0.25 0.33 0.10 7 LCH 0.65 0.47 0.32 0.26 0.09 8 HSS 0.43 0.34 0.24 0.15 0.05 No. Subject Test product (right eye) R1 R2 R3 R4 R5 9 GHO 0.47 0.36 0.22 0.17 0.06 10 KHY 0.53 0.43 0.27 0.16 0.05 11 SOJ 0.55 0.46 0.30 0.18 0.06 12 OYH 0.54 0.38 0.26 0.20 0.07 13 LYJ 0.46 0.38 0.25 0.15 0.05 14 JEM 0.64 0.52 0.33 0.20 0.07 15 JJH 0.43 0.33 0.24 0.16 0.05 Average 0.508 0.388 0.254 0.186 0.063 Standard Deviation 0.093 0.062 0.041 0.055 0.018 p value 0.025 0.002 0.000 0.657 0.158

Image analysis results after 8 weeks of product use No. Subject Test product (left eye corner) R1 R2 R3 R4 R5 One KJJ 0.37 0.32 0.21 0.11 0.03 2 SYJ 0.39 0.27 0.18 0.16 0.06 3 SHS 0.48 0.33 0.23 0.18 0.08 4 YHS 0.66 0.31 0.21 0.32 0.15 5 LDK 0.33 0.27 0.18 0.11 0.04 6 LEK 0.53 0.41 0.27 0.19 0.06 7 LCH 0.55 0.46 0.31 0.19 0.06 8 HSS 0.45 0.36 0.25 0.16 0.06 No. Subject Test product (right eye) R1 R2 R3 R4 R5 9 GHO 0.28 0.24 0.15 0.09 0.03 10 KHY 0.37 0.29 0.20 0.13 0.05 11 SOJ 0.57 0.41 0.28 0.20 0.08 12 OYH 0.57 0.38 0.26 0.24 0.09 13 LYJ 0.51 0.46 0.27 0.12 0.05 14 JEM 0.60 0.44 0.30 0.21 0.08 15 JJH 0.52 0.44 0.28 0.16 0.06 Average 0.479 0.359 0.239 0.171 0.065 Standard Deviation 0.110 0.075 0.048 0.059 0.029 p value 0.004 0.001 0.000 0.162 0.477

It can be seen from the results of Tables 3 to 5 that the wrinkle improvement effect of the composition of Example is excellent. This shows that the metal ion complex contained as an active ingredient in the composition of <Example> has an anti-wrinkle effect.

Formulation Example Formulation of Cosmetic Composition

Hereinafter, a formulation example of the cosmetic composition is described as a specific use example of the cosmetic composition of the present invention.

Preparation Example 1 Preparation Example of Nutrients Longevity (Milk Skin Lotion)

Nutritional Ingredients and Ingredients 1. Purified water QS to 100 2. Glycerin 8.0 3. Butylene glycol 4.0 4. Hyaluronic Acid 5.0 5. Beta Glucan 7.0 6. Carbomer 0.1 7. Metal Ion Complexes Quantity 8. Caprylic Capric Triglycerides 8.0 9. Squalane 5.0 10. Cetearyl Glucoside 1.5 11.Sorbitan Stearate 0.4 12. Cetearyl Alcohol 1.0 13. Preservative Quantity 14. Incense Quantity 15. Coloring Quantity 16. Triethanol Amine 0.1

Preparation Example 2 Preparation Example of Nutrition Cream

Ingredients and ingredients ratio of nutrition cream 1. Purified water Qs to 100 2. Glycerin 3.0 3. Butylene glycol 3.0 4. Liquid paraffin 7.0 5. Beta Glucan 7.0 6. Carbomer 0.1 7. Metal ion complex Quantity 8. Caprylic Capric Triglycerides 3.0 9. Squalane 5.0 10. Cetearyl Glucoside 1.5 11.Sorbitan Stearate 0.4 12. Polysorbate 60 1.2 13. Preservative Quantity 14. Incense Quantity 15. Coloring Quantity 16. Triethanolamine 0.1

Preparation Example 3 Formulation Example of Massage Cream

Ingredients and proportions of massage cream 1. Purified water Qs to 100 2. Glycerin 8.0 3. Butylene glycol 4.0 4. Liquid paraffin 45.0 5. Beta Glucan 7.0 6. Carbomer 0.1 7. Metal Complexes Quantity 8. Caprylic Capric Triglycerides 3.0 9. Beeswax 4.0 10. Cetearyl Glucoside 1.5 11.Sesqui oleic acid sorbitan 0.9 12. Vaseline 3.0 13. Preservative Quantity 14. Incense Quantity 15. Coloring Quantity 16. Paraffin 1.5

Formulation Example 4 Formulation Example

Ingredients and proportions of the pack 1. Purified water Qs to 100 2. Glycerin 4.0 3. Polyvinyl Alcohol 15.0 4. Hyaluronic Acid 5.0 5. Beta Glucan 7.0 6. Allantoin 0.1 7. Metal Complexes Quantity 8. Nonyl Phenyl Ether 0.4 9. Polysorbate 60 1.2 10. Preservative Quantity 11. Incense Quantity 12. Pigment Quantity 13. Ethanol 6.0

Claims (5)

Cosmetic composition containing a metal complex as an active ingredient to increase the percutaneous absorption effect when used with beauty equipment
The method of claim 1,
The metal complex may be a metal salt or a mixture of two or more metal salts, wherein the metal is gold (Au), silver (Ag), iron (Fe), cobalt (Co), nickel (Ni), chromium (Cr), and manganese (Mn). ), Barium (Ba), strontium (Sr), titanium (Ti), zirconium (Zr), platinum (Pt), palladium (Pd), ruthenium (Ru)
The method of claim 2,
The active ingredient complexed to the metal ion is a hydrocarbon containing at least one functional group, and the hydrocarbon is a C1 to C20 alkanethiol, alkanethiol derivative, and di-thiol and tri-thiol compound including a mercapto group (-SH). Or one selected from the group consisting of carbonyl group (-CO), ether group (-O-), ester group (-COO), nitro group (-NO ₂ ), amino group (-NH ₄ ), sulfonic acid group (-SO ₃ H), mercapto group (-SH), carboxyl group (-COOH), phosphonic acid group (-H ₃ PO _4), hydroxyl group (-OH), benzyl group (-C ₆ H _5), and Characterized in that it is one kind selected from the group consisting of compounds containing an alkyl group of C1 to C20 having one or more substituents selected from aldehyde groups (-CHO)
The method of claim 1,
Cosmetic formulations are classified into emulsion forms, which are water in oil (W / O), (O / W) oil in water, W / O / W (water in oil in water), O / W / O (oil in water in oil) ), Cosmetics including lamellar liquid crystal
The method of claim 1,
Conventional cosmetic formulations such as toners, lotions, essences, creams, gels, packs, sun creams, massage creams, foundations, and makeup bases.