KR20120033393A

KR20120033393A - Hydrogel pack using chitosan and method of preparing the same

Info

Publication number: KR20120033393A
Application number: KR1020100094883A
Authority: KR
Inventors: 최용복
Original assignee: (주)크론바이오
Priority date: 2010-09-30
Filing date: 2010-09-30
Publication date: 2012-04-09

Abstract

The present invention relates to a gel mask pack using chitosan, which will be described in more detail 0.1-10% by weight of one or two or more polysaccharides selected from the group consisting of chitosan, chitin and chitosan derivatives based on the total weight of the composition 3-30% by weight of one or more polyhydric alcohols selected from the group consisting of propylene glycol, 1,3-butylene glycol and glycerin, lactic acid, citric acid, glycolic acid, malic acid, and one selected from the group consisting of tartaric acid Or 0.1-20% by weight of two or more α-hydroxy acids, one or two or more natural extracts selected from the group consisting of bamboo sap, cypress sap, birch sap, taupe sap, and maple sap One or two or more polysaccharides selected from the group consisting of% by weight, agar, agarose, carrageenan, guar gum, locust bean gum and xanthan 0.05-3% by weight of one or two or more polymers selected from the group consisting of 0.2-3% by weight, polyvinyl alcohol, hydroxypropylcellulose, hydroxyethylcellulose, and hydroxymethylcellulose, and 33-96% by weight of water It relates to a method for producing a hydrogel pack using a hydrogel composition comprising a. Gel pack using chitosan of the present invention can be effectively used in the treatment of skin diseases due to skin care and antibacterial, such as waste removal, exfoliation.

Description

Hydrogel pack using chitosan and preparation method thereof {Hydrogel pack using chitosan and Method of preparing the same}

The present invention relates to a gel mask pack using chitosan, which will be described in more detail 0.1-10% by weight of one or two or more polysaccharides selected from the group consisting of chitosan, chitin and chitosan derivatives based on the total weight of the composition 3-30% by weight of one or more polyhydric alcohols selected from the group consisting of propylene glycol, 1,3-butylene glycol and glycerin, lactic acid, citric acid, glycolic acid, malic acid, and one selected from the group consisting of tartaric acid Or 0.1-20% by weight of two or more α-hydroxy acids, one or two or more natural extracts selected from the group consisting of bamboo sap, cypress sap, birch sap, taupe sap, and maple sap One or two or more polysaccharides selected from the group consisting of% by weight, agar, agarose, carrageenan, guar gum, locust bean gum and xanthan .2-3% by weight, 0.05-2% by weight of one or two or more polymers selected from the group consisting of polyvinyl alcohol, hydroxypropylcellulose, hydroxyethylcellulose, and hydroxymethylcellulose, and 33-96% by weight of water It relates to a method of producing a hydrogel pack using a hydrogel composition comprising%. Gel mask pack using chitosan of the present invention can be effectively used in the treatment of skin diseases due to skin care and antibacterial, such as waste removal, exfoliation.

Chitosan is a small change in the chemical structure of chitin (deacetylation), which is insoluble in water and alkali, but is insoluble in weak acids such as lactic acid, citric acid, and acetic acid, and is easily absorbed by enzymes. It is used more industrially than chitin. Chitosan is a high-value-added material that has a variety of characteristics without depletion because it is extracted from red crab, which is a natural polysaccharide of tasteless and odorless, which is harmless to human body. It shows excellent biocompatibility in tissues and bodies of humans, animals, plants, etc., is easily decomposed, environmentally friendly, and almost non-toxic, safe as a material, and has excellent moldability such as powder, fiber, membrane, and sponge-like structure. It has functions such as moisturizing, metal adsorption, antibacterial and antifungal activity. When ingesting chitosan, about 40% is absorbed by the body, and the remaining 60% activates the cells before excretion in vitro to suppress aging and strengthen immunity, thereby improving anti-cancer, decholesterol, liver function, release of heavy metals and contaminants in the body. It plays an important role in the body's bioregulatory function.

In general, the pack is to use a substance that can affect the skin in the desired area to leave a certain time to see the desired effect on the skin. The pack has been used for a long time as a major cosmetic product that keeps skin healthy and beautiful by performing moisturizing action to keep the skin moisturized, cleaning effect to adsorb and remove skin pollutants, and promoting blood circulation. These pack cosmetics can be used for topical or whole body as well as face, neck, shoulders, arms, legs, etc. Peel-off type, cream, clay , Jelly, Tissue-off type and wash-off type used as aerosol, peel-off type after solidification, nonwoven gel, nonwoven fabric impregnated coating type, etc. It is becoming. Each of these has advantages and disadvantages, and researchers formulating products compensate for their shortcomings by choosing the right type of formulation according to various consumer preferences.

Japanese Patent Laid-Open No. 57-1435008 proposes a gauze made from chitin fiber, and only suggests physical properties of the gauze, and Japanese Patent No. 8211258 only shows the adhesiveness of the chitin component in the process of combining various kinds of materials. It was used only for the purpose of doing so. Korean Patent No. 2001-19732 discloses a method for producing a functional fiber containing chitosan; Korean Patent No. 10-0589958 discloses a cosmetic composition for a pack having a high tensile strength and antibacterial effect by using chitosan and an inorganic salt, but has a relatively slow drying speed of the film. Korean Patent No. 2000-66617 discloses a method for preparing an amorphous water-soluble chitosan film that dramatically improves coating ability by using high purity chitosan obtained by high molecular weight from chitin.

In general, when chitosan is used as a main component as described above, the application of the fiber, membrane, and sheet-like structure has a non-soft property.

Therefore, in the art, various attempts have been made to construct structures such as fibrous or film in order to effectively use chitosan materials having various biocompatibility and functionality, but have not properly overcome the lack of flexibility of the sheet or film structure. There has been a demand for developing a soft gel sheet with a constant thickness using chitosan as a main component.

Therefore, the present inventors are difficult to adhere to the curved surface when the sponge-like multilayer structure sheet using chitosan is manufactured, and a small amount of chitosan is applied to the sheet mainly composed of other polymer components (synthetic or natural polymer). In order to overcome the problems that chitosan is difficult to achieve due to the addition of chitosan, chitosan is an active ingredient by making a chitosan as an aqueous solution, adding a polyhydric alcohol, and adding a gel forming aid to increase the flexibility of the pack. The invention was found to breakthrough and completed the present invention.

Hereinafter, the present invention will be described in more detail.

Method for producing a chitosan pack according to the present invention is 0.1-10% by weight of one or two or more polysaccharides selected from the group consisting of chitosan chitin and chitosan derivatives based on the total weight of the composition, water-soluble liquid propylene glycol, 1,3- 3-30% by weight of one or two or more polyhydric alcohols selected from the group consisting of butylene glycol and glycerin, one or two or more α-hydroxy selected from the group consisting of lactic acid, citric acid, glycolic acid, malic acid, and tartaric acid 0.1-20% by weight of one or two or more natural extracts selected from the group consisting of 0.1-2% by weight of acid, bamboo sap, cypress sap, birch sap, taraxa sap, and maple sap, agar, agarose, 0.2-3% by weight of one or more polysaccharides selected from the group consisting of carrageenan, guar gum, locust bean gum and xanthan, polyvinyl alcohol, hydroxypro Hydrogel using a hydrogel composition comprising 0.05-2% by weight of one or two or more polymers selected from the group consisting of cellulose, hydroxyethylcellulose, and hydroxymethylcellulose, and 33-96% by weight of water How to make a pack.

Step i) of the preparation step according to the present invention comprises 0.1-10% by weight of one or two or more polysaccharides selected from the group consisting of chitosan chitin and chitosan derivatives based on the total weight of the composition, a water-soluble liquid propylene glycol, 1, 3-30% by weight of one or two or more polyhydric alcohols selected from the group consisting of 3-butylene glycol and glycerin, one or two or more α- selected from the group consisting of lactic acid, citric acid, glycolic acid, malic acid, and tartaric acid 0.2-3% by weight of one or two or more polysaccharides selected from the group consisting of 0.1-2% by weight of hydroxy acid, agar, agarose, carrageenan, guar gum, locust bean gum and xanthan, polyvinyl alcohol, hydroxypropyl cellulose, High temperature by adding 0.05-2% by weight of one or two or more kinds of polymers selected from the group consisting of hydroxyethyl cellulose and hydroxymethyl cellulose to water Standing a step of dissolving in the bath.

Chitosan used in the above step is deacetylated chitin, the viscosity is 2cps to 400 cps, the degree of deacetylation is used 60 to 99%. The viscosity is a value measured with a Brookfield viscometer at 20 degrees using a 0.5% mass% chitosan solution in an aqueous 0.5 mass% acetic acid solution.

The aqueous solution of chitosan is prepared by dissolving chitosan at a concentration of 0.1 to 10% by mass relative to the aqueous solution. Dissolve for 1 to 2 days for complete dissolution of chitosan. The prepared aqueous solution is left under reduced pressure or room for 24 hours to completely remove air bubbles in the solution and completely remove impurities and insoluble residues with 1 to 25 μm of filter paper or gauze.

The acidic aqueous solution of chitosan is prepared by dissolving chitosan in an aqueous solution of α-hydroxy acid. Examples of α-hydroxy acids usable in the present invention include lactic acid, citric acid, glycolic acid, malic acid, tartaric acid, and mixed acids of two or more thereof, and the α-hydroxy acid concentration is 0.1 to 2 by weight to water. Weight percent.

Polyhydric alcohol is essentially added to the acidic aqueous solution of chitosan, but it is preferable to add 3 to 30 mass% by weight with respect to the aqueous solution. The polyhydric alcohols used are one or two or more selected from the group consisting of glycerin, propylene glycol and 1,3-butylene glycol, and when less than 3% by weight is added, it is difficult to expect an increase in tensile strength and elongation rate. It is insignificant and does not make the sheet soft, and when it exceeds 30% by weight, the drying speed is slow and the gel is weak.

In the chitosan aqueous solution, 0.2-3% by weight of one or two or more polysaccharides selected from the group consisting of agar, agarose, carrageenan, guar gum, locust bean gum and xanthan, polyvinyl alcohol, hydroxypropyl cellulose, and hydroxyethyl cellulose It is preferable to add 0.05-2% by weight of one or two or more polymers selected from the group consisting of and hydroxymethylcellulose. This imparts the property of containing and releasing moisture as an aid to the formation of chitosan hydrogels.

Step ii) of the manufacturing step according to the present invention, in the chitosan aqueous solution obtained in step i), one or two selected from the group consisting of bamboo sap, cypress sap, birch sap, stalk sap, and maple sap The addition of the sap in 0.1-20% by weight or more of the natural extract is included. The aqueous chitosan solution obtained in step i) contains an α-hydroxy acid component, and an appropriate amount of fruit acid shows the effects of skin beauty such as exfoliation. Depending on the end of the sap used, the degree is different but moisturizing effect on the skin, whitening effect.

Step iii) of the manufacturing step according to the present invention comprises the step of forming a hydrogel structure using the completed aqueous chitosan solution and completing the form at an appropriate level. Another step is that when forming a hydrogel using a support made of bamboo fiber, it inhibits pigmentation, inhibits aging, and makes the skin comfortable due to the far-infrared emission and anion generating effects that bamboo fiber additionally generates. Indicates.

The chitosan hydrogel structure obtained through the above steps is composed of hydrogel as well as antimicrobial activity, immune activity enhancement, and biocompatibility, which are inherent in chitosan, and it is easy to add various additives to establish additional functions. It can be used as a better chitosan hydrogel pack.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the technical scope of the present invention is not limited in any way by these Examples.

Gel-type structure pack using chitosan according to the present invention has improved mechanical properties compared to the conventional technique using chitosan having the form of fiber, film, powder, so that it is possible to easily contact the bent portion that is difficult to apply conventionally. Chitosan is used as the main ingredient and due to its increased capacity, it shows excellent antibacterial properties. In addition, due to the skin exfoliation ability of α-hydroxy acid (α-hydroxy acid, AHA) used, it shows the effect of skin improvement. Also, by adding tree sap, skin moisturizing and anti-aging effect can be seen.By using bamboo fiber as a support for hydrogel, far-infrared emission and anion generation induces comfort to the skin and increases the antibacterial effect.

Measure the physical properties as follows

(1) pH measurement

0.1 g of each of the above compositions was accurately weighed and placed in a 100 ml beaker, filled with purified ionized water to prepare 100 g, stirred until completely dissolved, and measured with a pH meter.

(2) hygroscopicity (%)

Each composition is cut to 4cm x 4cm size and the initial weight is measured, and then immersed in an experimental bucket of about 2L size containing purified ionized water for 1 hour, and then dried for 30 minutes on a drying stand to measure the weight.

Hygroscopicity (%) = (Weight after Acupuncture-Initial Weight) / Initial Weight x 100

(3) moisturizing

The sheet-shaped molded bodies prepared on the upper arms of 11 healthy adult women were cut and attached to a circular shape having a diameter of 15 mm, and the sheet molded bodies were removed after 2 hours, and the moisturizing force before and after the attachment was measured. Moisture retention test conditions were carried out at 23 ℃, relative humidity 50%, the skin hygrometer (skin hygrometer; skicon-200, IBS, co. Japan) was used. Before the pasting, the initial value was 10, and after 2 hours of removal, the measured values were converted into relative values and compared.

(4) The gel strength, adhesion, and skin dysplasia of the prepared compositions were compared to 20 quality evaluators on a 5-point scale.

{Evaluation standard}

1 point: very bad, 2 points: bad, 3 points: moderate, 4 points: excellent, 5 points: very good

(5) Skin irritation degree

The skin irritation degree was cut into sheets of 10 mm in diameter, attached to the inner upper arm of a healthy woman, and detached after 24 hours. The skin condition was visually determined and evaluated according to the following evaluation criteria. 0.1 parts by weight of sodium lauryl sulfate was used. Such skin irritation degree was for the manufactured sheet-like molded object. The results are shown in the following [Table], and according to the measurement results, all the subjects showed the level of little stimulation.

{Skin irritation evaluation criteria}

0 points: no irritation, 1 point: mild irritation, 2 points: erythema, 3 points: erythema and edema, 4 points: erythema, edema and blister

(6) antibacterial activity test

In order to examine the antimicrobial activity, a challenge test according to the inoculation of microorganisms such as bacteria and fungi was conducted. As a test method, the samples were added to the agar medium, inoculated with bacteria and fungi, and then stored in a thermostat, and the number of viable cells was measured after 21 days, 1 day, 7 days, and 14 days. Bacteria were mixed with E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, and fungi were Candida albicans and Aspergillus. A mixture of Niger (Aspergilus niger) was used.

While stirring in a 1 liter container that can be heated at room temperature, 860 g of distilled water was added to the mixed solution to which 50 g of glycerin and 2.5 g of α-hydroxy acid were added, followed by stirring. Then, 15 g of chitosan was added to dissolve the chitosan sufficiently. . 4 g of polyvinyl alcohol was added, and 12 g of agar was added to increase the temperature to 95 ° C. and maintained for 1 hour to prepare a gel solution. Hydrogel composition was prepared by sequentially adding 20 g of bamboo sap, 20 g of mung bean extract, and 10 g of licorice extract to the gel solution while maintaining the temperature at 95 ° C. Thereafter, while maintaining the temperature at 80 ° C., a hydrogel composition was prepared by adding 10 g of lavender extract and 0.2 g of a natural preservative to the gel solution. The hydrogel composition was formed into a hydrogel sheet using a mesh fabric woven from bamboo fibers at 80 ° C. as a support, and cooled to room temperature to produce a sheet.

While stirring in a 1 liter container that can be heated at room temperature, 823 g of distilled water was added to the mixed solution to which 50 g of glycerin and 2.5 g of α-hydroxy acid were added, followed by stirring, and 15 g of chitosan was added to dissolve the chitosan sufficiently. . 8 g of polyvinyl alcohol was added and 15 g of agar was added to maintain the temperature at 95 ° C. for 1 hour to prepare a gel solution. Hydrogel composition was prepared by sequentially adding 50 g of bamboo sap, 20 g of mung bean extract, and 10 g of licorice extract to the gel solution while maintaining the temperature at 95 ° C. Thereafter, while maintaining the temperature at 80 ° C., a hydrogel composition was prepared by adding 10 g of lavender extract and 0.2 g of a natural preservative to the gel solution. The hydrogel composition was formed into a hydrogel sheet using a mesh fabric woven from bamboo fibers at 80 ° C. as a support, and cooled to room temperature to produce a sheet.

While stirring in a 1 liter container that can be heated at room temperature, 834 g of distilled water was added to the mixed solution to which 50 g of glycerin and 5.0 g of α-hydroxy acid were added, followed by stirring. Then, 30 g of chitosan was added to dissolve the chitosan sufficiently. . 4 g of polyvinyl alcohol was added, and 20 g of agar was added to increase the temperature to 95 ° C. and maintained for 1 hour to prepare a gel solution. Hydrogel composition was prepared by sequentially adding 20 g of bamboo sap, 20 g of mung bean extract, and 10 g of licorice extract to the gel solution while maintaining the temperature at 95 ° C. Thereafter, while maintaining the temperature at 80 ° C., a hydrogel composition was prepared by adding 10 g of lavender extract and 0.2 g of a natural preservative to the gel solution. The hydrogel composition was formed into a hydrogel sheet using a mesh fabric woven from bamboo fibers at 80 ° C. as a support, and cooled to room temperature to produce a sheet.

While stirring in a 1 liter container which can be heated at room temperature, 814 g of distilled water was added to the mixed solution to which 70 g of glycerine and 5.0 g of α-hydroxy acid were added, followed by stirring. Then, 30 g of chitosan was added to dissolve the chitosan sufficiently. . 4 g of polyvinyl alcohol was added, and 20 g of agar was added to increase the temperature to 95 ° C. and maintained for 1 hour to prepare a gel solution. Hydrogel composition was prepared by sequentially adding 20 g of bamboo sap, 20 g of mung bean extract, and 10 g of licorice extract to the gel solution while maintaining the temperature at 95 ° C. Thereafter, while maintaining the temperature at 80 ° C., a hydrogel composition was prepared by adding 10 g of lavender extract and 0.2 g of a natural preservative to the gel solution. The hydrogel composition was formed into a hydrogel sheet using a mesh fabric woven from bamboo fibers at 80 ° C. as a support, and cooled to room temperature to produce a sheet.

While stirring in a 1 liter container that can be heated at room temperature, 802 g of distilled water was first added to a mixed solution to which 100 g of glycerin and 2.5 g of α-hydroxy acid were added, followed by stirring. Then, 15 g of chitosan was added to dissolve the chitosan sufficiently. . 4 g of polyvinyl alcohol was added, and 20 g of agar was added to increase the temperature to 95 ° C. and maintained for 1 hour to prepare a gel solution. Hydrogel composition was prepared by sequentially adding 20 g of bamboo sap, 20 g of mung bean extract, and 10 g of licorice extract to the gel solution while maintaining the temperature at 95 ° C. Thereafter, while maintaining the temperature at 80 ° C., a hydrogel composition was prepared by adding 10 g of lavender extract and 0.2 g of a natural preservative to the gel solution. The hydrogel composition was formed into a hydrogel sheet using a mesh fabric woven from bamboo fibers at 80 ° C. as a support, and cooled to room temperature to produce a sheet.

While stirring in a 1 liter container that can be heated at room temperature, 860 g of distilled water was added to the mixed solution to which 50 g of 1,3-butylene glycol and 2.5 g of α-hydroxy acid were added and stirred, followed by 15 g of chitosan. It was prepared to be sufficiently melted. 4 g of polyvinyl alcohol was added, and 12 g of agar was added to increase the temperature to 95 ° C. and maintained for 1 hour to prepare a gel solution. Hydrogel composition was prepared by sequentially adding 20 g of bamboo sap, 20 g of mung bean extract, and 10 g of licorice extract to the gel solution while maintaining the temperature at 95 ° C. Thereafter, while maintaining the temperature at 80 ° C., a hydrogel composition was prepared by adding 10 g of lavender extract and 0.2 g of a natural preservative to the gel solution. The hydrogel composition was formed into a hydrogel sheet using a mesh fabric woven from bamboo fibers at 80 ° C. as a support, and cooled to room temperature to produce a sheet.

While stirring in a 1 liter container that can be heated at room temperature, first, 823 g of distilled water was added to the mixed solution to which 50 g of 1,3-butylene glycol and 2.5 g of α-hydroxy acid were added, followed by stirring, and 15 g of chitosan was added thereto. It was prepared to be sufficiently melted. 8 g of polyvinyl alcohol was added and 15 g of agar was added to maintain the temperature at 95 ° C. for 1 hour to prepare a gel solution. Hydrogel composition was prepared by sequentially adding 50 g of bamboo sap, 20 g of mung bean extract, and 10 g of licorice extract to the gel solution while maintaining the temperature at 95 ° C. Thereafter, while maintaining the temperature at 80 ° C., a hydrogel composition was prepared by adding 10 g of lavender extract and 0.2 g of a natural preservative to the gel solution. The hydrogel composition was formed into a hydrogel sheet using a mesh fabric woven from bamboo fibers at 80 ° C. as a support, and cooled to room temperature to produce a sheet.

(Comparative Example 1)

To 35.0 g of glycerin, 2.0 g of carboxymethyl cellulose and 2.0 g of sodium polyacrylate (polymerization degree 40,000 to 50,000) were added to disperse uniformly, and 0.08 g of aluminum chloride (0.009 parts by weight as aluminum) was added to 40% sodium polyacrylate salt (polymerization degree). 50 to 90) A crosslinking agent dissolved in 5.0 g of aqueous solution is added and stirred. Here, 30.0 g of 20% polyacrylic acid (polymerization degree 3,000 to 5,000) aqueous solution dissolved in 25.82 g of purified ionized water in which 0.1 g of titanium dioxide was dispersed was stirred uniformly. The obtained composition is applied to a release paper at a thickness of 1 mm using a doctor braid, bonded to a nonwoven fabric, and cut into a constant shape.

(Comparative Example 2)

To 30.0 g of glycerin, 1.2 g of carboxymethyl cellulose and 2.0 g of sodium polyacrylate (polymerization degree 40,000 to 50,000) were added and dispersed uniformly, 0.65 g of aluminum chloride (0.073 parts by weight as aluminum) and sodium polyacrylate salt (polymerization degree of 50 to 90) ) 4.0 g of the cross-linking agent dissolved in 10.0 g of purified ionized water is added and stirred. Here, 30.0 g of 20% aqueous polyacrylic acid (polymerization degree 3,000 to 5,000) solution was dissolved in 22.05 g of purified ionized water in which 0.1 g of titanium dioxide was dispersed, and then stirred uniformly. The obtained composition is applied to a release paper at a thickness of 1 mm using a doctor braid, bonded to a nonwoven fabric, and cut into a constant shape.

PH of the prepared compositions pH Example 1
Example 2
Example 3
Example 4
Example 5
Example 6
Example 7 5.3
5.2
5.1
5.1
5.3
5.2
5.1 Comparative Example 1
Comparative Example 2 5.2
5.0

Moisturizing power, gel strength, adhesion, skin dysplasia, skin irritation Moisturizing Gel strength Adhesion Dysplasia Skin irritation Example 1
Example 2
Example 3
Example 4
Example 5
Example 6
Example 7 42.3
43.1
44.3
47.7
49.2
41.2
42.4 3.9
4.1
4.2
4.3
3.8
3.6
3.8 4.3
4.4
4.2
4.5
4.0
4.2
4.3 4.5
4.3
4.4
4.2
4.1
4.3
4.3 0.3
0.4
0.6
0.5
0.2
0.7
0.6 Comparative Example 1
Comparative Example 2 45.5
41.2 2.0
4.3 2.0
1.2 2.3
4.5 0.5
0.7

Test result for bacteria sample Viable cell count (CFU / g) Day 1 Day 7 Day 14 Example 1
Example 2
Example 3
Example 4
Example 5
Example 6
Example 7 2.2 x 10 ²
2.1 x 10 ²
2.3 x 10 ²
2.2 x 10 ²
2.3 x 10 ²
2.2 x 10 ²
2.1 x 10 ² <10
<10
<10
<10
<10
<10
<10 0
0
0
0
0
0
0 Comparative Example 1
Comparative Example 2 2.1 x 10 ⁵
2.2 x 10 ³ 2.4 x 10 ⁴
1.2 x 10 ³ 2.2 x 10 ³
1.0 x 10 ³

Test results for fungi sample Viable cell count (CFU / g) Day 1 Day 7 Day 14 Example 1
Example 2
Example 3
Example 4
Example 5
Example 6
Example 7 2.2 x 10 ²
2.2 x 10 ²
<20
<20
2.3 x 10 ²
2.4 x 10 ²
2.3 x 10 ² 0
0
0
0
0
0
0 0
0
0
0
0
0
0 Comparative Example 1
Comparative Example 2 2.4 x 10 ⁴
2.2 x 10 ³ 2.0 x 10 ⁴
1.8 x 10 ³ 1.5 x 10 ⁴
1.2 x 10 ³

Claims

0.1-10% by weight of one or two or more polysaccharides selected from the group consisting of chitosan chitin and chitosan derivatives, based on the total weight of the composition, selected from the group consisting of soluble propylene glycol, 1,3-butylene glycol and glycerin 0.1-2 weight% of one or two or more α-hydroxy acids selected from the group consisting of 3-30 weight% of one or two or more polyhydric alcohols, lactic acid, citric acid, glycolic acid, malic acid, and tartaric acid, bamboo sap, 0.1-20% by weight of one or two or more natural extracts selected from the group consisting of cypress sap, birch sap, cypress sap, and maple sap, agar, agarose, carrageenan, guar gum, locust bean gum and xanthan 0.2-3% by weight of one or two or more polysaccharides selected from the group consisting of polyvinyl alcohol, hydroxypropyl cellulose, hydroxyethyl cellulose, Process for producing a hydrogel composed of packs with a hydrogel composition including hydroxymethyl cellulose, of one or more polymers selected from the group consisting of 0.05-2% by weight, and water 33 to 96% by weight

[Claim 2] The method of claim 1, wherein the chitosan uses chitosan and chitosan derivatives in the range of 2 cps to 400 cps viscosity and in the range of 60% to 99% deacetylation.

0.1-10% by weight of one or two or more polysaccharides selected from the group consisting of chitosan chitin and chitosan derivatives, based on the total weight of the composition, selected from the group consisting of soluble propylene glycol, 1,3-butylene glycol and glycerin 0.1-2 weight% of one or two or more α-hydroxy acids selected from the group consisting of 3-30 weight% of one or two or more polyhydric alcohols, lactic acid, citric acid, glycolic acid, malic acid, and tartaric acid, bamboo sap, 0.1-20% by weight of one or two or more natural extracts selected from the group consisting of cypress sap, birch sap, cypress sap, and maple sap, agar, agarose, carrageenan, guar gum, locust bean gum and xanthan 0.2-3% by weight of one or two or more polysaccharides selected from the group consisting of polyvinyl alcohol, hydroxypropyl cellulose, hydroxyethyl cellulose, Gauze woven from bamboo fibers using a hydrogel composition comprising 0.05-2% by weight of one or two or more polymers selected from the group consisting of hydroxymethylcellulose, and 33-96% by weight of water, and a support of the hydrogel Or manufacturing a chitosan hydrogel pack using a woven or nonwoven fabric

[Claim 3] The chitosan hydrogel pack according to claim 2, wherein the chitosan uses chitosan and chitosan derivatives in the range of 2 cps to 400 cps viscosity and in the range of 60% to 99% deacetylation.

The method of claim 2, wherein the bamboo fiber is a pure bamboo fiber of 0.01 to 100% by weight polyester fiber, nylon fiber, polyurethane fiber, polypropylene fiber, polyvinyl alcohol fiber, rayon fiber, acetate fiber, cotton To prepare a chitosan hydrogel pack characterized in that a fiber made by mixing with one or two or more fibers selected from the group consisting of synthetic fibers such as fibers, hemp fibers, wool fibers, regenerated fibers and natural fibers as a support Way