KR20110121292A - Cosmetic composition for body slimming - Google Patents

Abstract

PURPOSE: A cosmetic composition containing plant mixture extract is provided to accumulate neutral fat accumulated in adipocytes and to ensure anti-obesity. CONSTITUTION: A cosmetic composition for body sliming contains mixture extract of 1-40 wt% of Cinnamomum cassia Blume, 1-40 wt% of Allium sativum L., 1-40 wt% of Crataegus pinnatifida, or 1-40 wt% of Codonopsis lanceolata. The mixture extract is contained in 0.001-10 wt% based on total composition. The cosmetic composition is manufactured in the form of a lotion, gel, soluble liquid, cream, essence, oil-in-water(O/W) type or water-in-oil type formulation.

Description

Cosmetic composition for body slimming {Cosmetic Composition for Body Slimming}

The present invention relates to a cosmetic composition having an effect of body slimming, and more particularly, a cosmetic composition containing an extract extracted from a mixture of two or more selected from the group consisting of cinnamon, garlic, hawthorn and deodeok accumulated in fat cells. It accelerates the process of breaking down triglycerides into glycerol and free fatty acids, reduces body fat, inhibits obesity, reduces cellulite, and is less irritating to skin. Therefore, it relates to a body slimming cosmetic composition which is safe for the human body and has no side effects even when used for a long time.

The present invention relates to a cosmetic composition that helps to slim the body, and more particularly, to a cosmetic composition that exhibits a slimming effect such as promoting triglyceride decomposition, reducing body fat, and reducing cellulite in adipocytes.

The cells responsible for accumulating or releasing energy in the human body are adipocytes, which are stored as triglycerides in adipocytes when the supply is much higher than the demand for energy, and then glycerol when energy is depleted. Decomposed into glycerol and free fatty acids. Obesity occurs when excessive energy builds up due to the imbalance of this process, which is caused by the increase or increase of fat cells, which usually refers to the abnormal enlargement of subcutaneous adipose tissue under the skin layer.

Cellulite is a phenomenon in which the skin becomes rugged like a rough orange peel due to circulatory disorder caused by excessive fat and waste accumulation, and it occurs only in the skin and subcutaneous fat of women. In addition to the accumulation of abnormal subcutaneous adipose tissue, cellulite is a type of swelling that appears as a result of swelling of the lymphatic tissue in the interstitial tissues, which makes it look as if it is fat. In addition to the problem, toxic substances accumulate in the body, which adversely affects skin cells and inhibits ionization activities for nutritional intake of cells, thereby causing skin aging and necrosis of cells. The cause of cellulite is different from simple obesity, but it is basically caused by the increase or hypertrophy of fat cells, so it is ultimately healthy and slim and smooth to break down and release fat in fat cells. It can be a great help to build your body.

Most known lipolysis promoting substances are methylxanthine substances, such as caffeine and theophylline, which are enzymes closely related to lipolysis in adipocytes, adenylatecyclase. It shows the effect of lipolysis through the promotion of or the inhibitory effect of phosphodiesterase. However, they are known to have a wide range of adverse reactions, such as addictive substances, and to induce bronchial expansion or worsen premenstrual syndrome, so there is no clear guarantee on safety. Therefore, there is a need to develop a new material that is equivalent to or higher than the above substances but more safe for the human body.

Therefore, the present inventors contain an extract extracted from a mixture of two or more selected from the group consisting of cinnamon, garlic, hawthorn and deodeok, thereby promoting the process of decomposing and releasing triglycerides accumulated in adipocytes into glycerol and free fatty acids. To reduce body fat, reduce obesity, reduce cellulite, less skin irritation, natural extracts are safe for human body and no side effects even after long-term use It was intended to invent the composition.

The present invention has been made to solve the above-mentioned problems, an object of the present invention is to contain the extract extracted from a mixture of two or more selected from the group consisting of cinnamon, garlic, hawthorn and deodeok, triglycerides accumulated in fat cells Promotes the process of decomposing and dissociating glycerol and free fatty acids, reduces body fat, inhibits obesity, reduces cellulite, and is less irritating to the skin. It is to provide a cosmetic composition for body slimming that is safe to and does not have side effects even after long-term use.

In addition, another object of the present invention is to provide an extraction method for effectively extracting a mixture of cinnamon, garlic, hawthorn and deodeok uniformly mixed at a constant mixing ratio.

Hereinafter, the present invention will be described in detail so that those skilled in the art can easily practice.

Body slimming cosmetic composition according to the invention is characterized in that it contains an extract of a single or a mixture thereof selected from the group consisting of cinnamon, garlic, hawthorn and deodeok.

In one embodiment of the invention, the composition of a given cinnamon, garlic, hawthorn and deoderm mixture according to the invention is based on dry weight of 1 to 40% by weight cinnamon, 1 to 40% by weight garlic, 1 to 40% hawthorn It is preferred to include by weight, and 1 to 40% by weight.

Cinnamon, garlic, hawthorn and deodeok, the active ingredients of the cosmetic composition of the present invention has the following characteristics.

Cinnamon is a bark of Cinnamomum cassia Blume or a similar bark of bark of the same plant, with spicy and warm properties, warming the stomach, and killing wind and cold sand. It is effective in getting rid of blood flow. It has been reported to promote circulation of blood and to treat old boils and poor skin ulcers and to inhibit skin fungi.

Garlic ( Allium sativum L.) is a genus of Allium in the Liliumaceae family, but it is a cold-frosted wintering vegetable, but it is not cold-resistant and weakly resistant. Garlic has been widely used for spices and herbal medicine since ancient times because of its unique taste, aroma and pharmacological effects. Garlic cultivated in Korea is divided into Korean type garlic and Nanji type garlic according to ecological type. Cold-grown garlic exhibits high temperature uniformity, while warm-type garlic exhibits low temperature uniformity. Garlic is not only a spice but also has 100 benefits, and it is a food that is beneficial to our body, so called 'ilhaebaekri' in oriental medicine. It has been known. This physiological activity is due to the formation of allicin (alliin) produced by allinase (alliinase) and 2-vinyl- [4H] -1,3-ditin (2) produced by the decomposition or binding of the allicin again. -vinyl- [4H] -1,3-dithin), 2-vinyl- [4H] -1,2-ditin (2-vinyl- [4H] -1,2-dithin), ajoene It is reported.

Sansa is picked from the fruit of Crataegus pinnatifida and dried in the sun. The hawthorn tree is commonly called agawi tree. It grows on the stream streams in central and northern Korea, and the fruit ripens red from September to October. The herbal medicine Sansa has no taste and strong acidity, so it is ideal for soaking alcohol. Its excellent efficacy as a gastrointestinal drug enhances the activity of the stomach and enhances digestive function, as well as efficacy in U.K. Sansa is a comprehensive medicine for health and dressing. It is also taken as a decoction or made as a powder. Flavonoids, rutin and oleanolic acid are known as main ingredients.

Codonopsis lanceolata ) is also called samsam, a perennial herbaceous herbaceous herbaceous perennial herb, about 2 m long, and its location is unique with its unique scent. Eliminates lung fever from oriental medicine and contains phlegm, fever, dry mouth, fever in the lungs, cough and sputum, used for hemorrhage. It is used as a tonic tonic in the private sector.

Extracts of a mixture of two or more selected from the group consisting of cinnamon, garlic, hawthorn and deodeok described above may be included in an amount of 0.001 to 10 parts by weight based on the total composition. When the extract is included in less than 0.001 parts by weight, the body slimming effect may be insignificant, when it is included in more than 10 parts by weight, the stability of the formulation may be lowered, the fragrance may not be good when manufacturing cosmetics.

Extracts of a mixture of two or more selected from the group consisting of cinnamon, garlic, hawthorn and deodeok described above are deposited for a predetermined time by adding a hydrophilic organic solvent such as methanol and ethanol or a mixed solution of a hydrophilic organic solvent and water as an extraction solvent. The solution obtained after stirring at intervals can be obtained according to the usual natural product extraction method by filtration and recovery.

Preferred extraction solvents include alcohol solvents having 1 to 4 carbon atoms such as methanol, ethanol, propyl alcohol, butyl alcohol, glycerin propylene glycol and butylene glycol, water and mixtures thereof. The amount of the extraction solvent added to the natural material may be about 1 to 50 times the total volume of the natural material.

In one embodiment of the invention, it is preferable to use a solvent selected from the group consisting of anhydrous methanol, hydrous methanol, anhydrous ethanol, hydrous ethanol and mixtures thereof as a natural extractant. In another embodiment of the present invention, it is preferable to use a mixed solvent of one of the aforementioned methanol solvents and one of the aforementioned ethanol solvents.

At the time of extraction, the amount of the extraction solvent added is preferably 5-20 ml per 1 g of the dry weight of the natural product material. Extraction conditions of the natural product material may be used by immersion extraction for 1-7 days at room temperature or 1-5 hours extraction under a heating condition of 50 ~ 95 ℃, but is not limited to these general solvent extraction used in the art All of the methods can be applied.

The formulation of the cosmetic composition containing an extract of a mixture of at least two kinds selected from the group consisting of cinnamon, garlic, hawthorn and deodeur is not particularly limited and may be appropriately selected as desired. For example, the topical skin composition of the present invention may be selected from a lotion, gel, water-soluble liquid, cream, essence, oil-in-water (O / W) type and water-in-oil (W / O) type.

In addition, the topical skin composition of the present invention is an additive such as oil, water, a surfactant, a moisturizer, a lower alcohol, a thickener, a chelating agent, a pigment, a preservative, or a flavoring agent, which are formulated in general skin cosmetics in addition to the components described above in each formulation. It can mix suitably and use it as needed.

Body slimming cosmetic composition of the present invention containing an extract extracted from a mixture of two or more selected from the group consisting of cinnamon, garlic, hawthorn and deodeok as described above,

First, there is an advantage that the body slimming effect such as promoting triglyceride decomposition, body fat reduction, cellulite reduction in fat cells.

Second, using the extract of natural origin, less skin irritation, safe for the human body, there is no side effect even for long-term use.

Third, it is possible to formulate in a variety of formulations, excellent durability of the effect.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. This is for the purpose of illustrating the present invention, and thus the scope of the present invention is not limited thereto.

< Manufacturing example > Preparation of Mixed Extracts

To a mixture of 20% by weight of cinnamon, 20% by weight of garlic, 40% by weight of sand, and 20% by weight of deodeok, add 80% ethanol to the volume of about 2 times the amount of the mixture, and cool it for 3 days, and then collect all the solutions. After filtration with filter paper, the solvent was removed using an evaporator, dried in a freeze dryer, dried for at least 48 hours to obtain a powder state.

< Experimental Example  1> lipolysis effect test

In order to confirm the skin slimming effect of the cinnamon, garlic, hawthorn and Deodeok extract prepared in Preparation Example 1 was subjected to a lipolysis effect test.

Since triglycerides in adipocytes are broken down into glycerol and free fatty acids during lipolysis, the fat degradability evaluation was used to quantify free glycerol.

After the rats were anesthetized with ester, the fat cells surrounding the testes were detached and treated with collagenase to separate the fat cells. Samples were applied to the isolated adipocytes, and 0.1 ml of the buffer solution was added instead of the sample as a control, and caffeine was used as a comparative group, which was known as an excellent lipolytic substance. Glycerol was quantitatively determined by color reaction using GPO-trinder kit purchased from Sigma Co., Ltd. (St. Louis, MO, USA), and the absorbance at 540 nm was measured using an ELISA reader. When the value is 100%, other values are shown in terms of conversion. The experimental results are shown in Table 1 below.

division density Free Glycerol Amount
(% of control)
Cinnamon, Garlic, Haw and Deodorant Extracts 0.001% 120 0.01% 125 0.1% 140 One % 175 10% 185 Caffeine 10 μM 180 control 100

As a result, 10% concentration of cinnamon, garlic, hawthorn and Deodeok extracts showed a similar level of lipolysis to caffeine, and even lower concentrations showed higher lipolysis than control.

< Example  And Comparative Examples> body For slimming  Manufacture of cream

To prepare a body slimming cream in the composition of Table 2 by a method known in the art. The unit in Table 2 is weight percent.

Ingredient Name Content (% by weight) Example 1 Example 2 Comparative Example 1 Cinnamon, Garlic, Haw and Deodorant Extracts 1.0 10.0 - glycerin 5.0 5.0 5.0 Stearic acid 8.0 8.0 8.0 Squalane 5.0 5.0 5.0 Self-emulsifying glycerin monostearate 2.5 2.5 2.5 Monostearic acid polyoxyethylene sorbitan 1.5 1.5 1.5 Propylene glycol 4.0 4.0 4.0 Stearyl glycyrrhetinate 0.2 0.2 0.2 vaseline 2.0 2.0 2.0 Antioxidant Quantity Quantity Quantity Spices Quantity Quantity Quantity antiseptic Quantity Quantity Quantity Purified water Balance Balance Balance

< Experimental Example  2> safety test for skin

Human patch test was performed to evaluate the degree of irritation to the skin. The skin patch test was carried out on 20 normal people over 20 years old. The samples were prepared in 1% and 10% aqueous solution, and then attached to the inner region of the upper arm for 48 hours using a Finn chamber. After 72 hours, a second reading was performed to determine the skin reaction result. Evaluation criteria and stimulation index calculations are shown in Table 3 and the results are shown in Table 4.

reaction weight Evaluation standard - 0.0 No response ± 0.5 Suspected positive reaction + 1.0 Weak positive reaction ++ 2.0 Strong positive reaction +++ 3.0 Polar positive reaction

(Equation 1)

Skin irritation index = Σ (weighted number of responders) / (highest weight X total number of subjects) × 100

sample Skin irritation index Classification of stimuli Distilled water (negative control) 0.4 No stimulation Cinnamon, Garlic, Hawthorn, and Cure (1%) 0.4 No stimulation Cinnamon, Garlic, Hawthorn, and Cure (10%) 0.8 No stimulation Cream containing 1% cinnamon, garlic, hawthorn, and tortilla (Example 1) 0.4 No stimulation Cream containing 10% cinnamon, garlic, hawthorn, and tortilla (Example 2) 0.8 No stimulation Comparative Example 1 0.4 No stimulation

As a result, less than 10% of cinnamon, garlic, hawthorn and Deodeok extracts were found to be non-irritating to the skin. In addition, creams containing 1% and 10% of these extracts, respectively, also show no irritation and are considered safe for the skin.

< Experimental Example  3> clinical trial

Among women with local obesity or cellulite, 20 adult women under 20 years of age with a BMI (Body Mass Index) of 21-27 were included in Example 1, Comparative Example, respectively, on the left and right thighs. One was given to the abdomen and thighs for 5 weeks, once each in the morning and evening for 8 weeks.

1. for thighs Slimming  effect

After 8 weeks of use of Example 1 and Comparative Example 1, the thigh circumference before and after use was measured using a tape measure (unit: mm), and the difference in thigh circumference was calculated to evaluate the slimming effect. Thigh circumference was measured after marking a certain part of both thighs. The results are shown in Table 5 according to Equation 2.

(Equation 2)

Thigh circumference change (mm) = thigh circumference after 8 weeks-thigh circumference before use

Thigh circumference change (mm) Example 1 24 Comparative Example 1 4

As can be seen in Table 5, it can be seen that the thigh circumference using Example 1 was significantly reduced than the thigh circumference using Comparative Example 1.

2. Cellulite  thickness

Ultrasound-EuB 415 US scanner was used to measure the thickness (in mm) of subcutaneous fat layer and infiltrated cellulite using ultrasound. According to Equation 3, the results are shown in Table 6 below.

(Equation 3)

% Reduction in cellulite thickness = {(Cellulite thickness before use-cellulite thickness after use) / Cellulite thickness before use} X 100

Cellulite Thickness Reduction (%) Example 1 32 Comparative Example 1 8

3. for the abdomen Slimming  effect

After 8 weeks, abdominal and body fat rates before and after use were evaluated using an Inbody body composition analyzer. Abdominal fat percentage was calculated by measuring the maximum waist circumference at the navel line and dividing it around the hips. The results are shown in Table 7 below.

division Before use 8 weeks after use Example 1 Body fat percentage (%) 27.4 23.9 WHR (abdominal fat percentage) 0.86 0.74 Comparative Example 1 Body fat percentage (%) 27.8 26.8 WHR (abdominal fat percentage) 0.88 0.83

As can be seen in Table 7, when using Example 1, it can be seen that the body fat percentage (%) and WHR (abdominal fat percentage) reduction is greater than that of Comparative Example 1.

From the above clinical trial results, it can be seen that the effect of the body slimming cosmetic composition containing a mixed extract of cinnamon, garlic, hawthorn and deodeok is excellent.

Hereinafter, based on the results of the experimental example described above, various formulation examples using a mixed extract of cinnamon, garlic, hawthorn and deodeok are presented. However, these formulation examples are intended to illustrate the present invention, and it is apparent to those skilled in the art that the formulation of the present invention is not limited to these formulation examples.

< Formulation example  1> flexible lotion ( skin toner ) Ingredient Name Content (% by weight) Cinnamon, Garlic, Haw and Deodorant Extracts 1.0 glycerin 5.0 1,3-butylene glycol 3.0 ethanol 5.0 Polyoxyethylene nonylphenyl ether 0.5 Spices Quantity antiseptic Quantity Purified water Balance

< Formulation example  2> astringent lotion ( astrigent ) Ingredient Name Content (% by weight) Cinnamon, Garlic, Haw and Deodorant Extracts 1.0 glycerin 3.0 Citric acid 0.1 ethanol 10.0 Polyoxyethylene oleyl ether 1.0 Sorbitol 2.0 Spices Quantity antiseptic Quantity Purified water Balance

< Formulation example  3> lotion ( emulsion ) Ingredient Name Content (% by weight) Cinnamon, Garlic, Haw and Deodorant Extracts 1.0 glycerin 5.0 1,3-butylene glycol 8.0 Squalane 10.0 Monooleic acid polyoxyethylene sorbitan 2.0 Triethanolamine 1.5 Glyceryl Stearate 0.5 Stearyl glycyrrhetinate 0.2 Carboxy Vinyl Polymer 0.1 Arginine 0.1 Spices Quantity antiseptic Quantity Purified water Balance

< Formulation example  4> Essence ( essence ) Ingredient Name Content (% by weight) Cinnamon, Garlic, Haw and Deodorant Extracts 1.0 Sorbitol 8.0 Polyoxyethylene glycol 1500 6.0 ethanol 5.0 glycerin 3.0 1,3-butylene glycol 3.0 Polyoxyethylene oleyl alcohol ether 1.0 olive oil 0.3 Hyaluronic acid 0.2 Antioxidant Quantity Spices Quantity antiseptic Quantity Purified water Balance

< Formulation example  5> Gel ( gel ) Ingredient Name Content (% by weight) Cinnamon, Garlic, Haw and Deodorant Extracts 1.0 ethanol 10.0 glycerin 4.0 Propylene glycol 4.0 Polyoxyethylene Cured Castor Oil 0.1 Carboxy Polymer 0.3 Triethanolamine 0.3 Antioxidant Quantity Spices Quantity antiseptic Quantity Purified water Balance

< Formulation example  6> ointment Ingredient Name Content (% by weight) Cinnamon, Garlic, Haw and Deodorant Extracts 10.0 Cetostearyl alcohol 2.0 Self-emulsifying monostearic acid 2.0 Stearic acid 1.0 Beeswax 4.0 Squalane 7.0 Monostearine Glycerin 3.0 Sorbitan monostearate 1.0 Polysorbate 80 3.0 glycerin 5.0 Propylene glycol 4.0 Spices Quantity Pigment Quantity Vaseline Balance

Claims (7)

Body slimming cosmetic composition, characterized in that it contains an extract of a mixture of two or more selected from the group consisting of cinnamon, garlic, hawthorn and deodeok. According to claim 1, wherein the extract is a body slimming cosmetic composition, characterized in that the extract of a mixture of cinnamon, garlic, hawthorn and deodeok. The cosmetic composition according to claim 1 or 2, wherein the extract is contained in an amount of 0.001 to 10% by weight based on the total weight of the composition. The body according to claim 2, wherein the composition of the mixture is 1 to 40% by weight of cinnamon, 1 to 40% by weight of garlic, 1 to 40% by weight of hawthorn, and 1 to 40% by weight of detox. Slimming cosmetic composition. The cosmetic composition according to claim 1 or 2, wherein the extract has a triglyceride promoting effect. The cosmetic composition according to claim 1 or 2, wherein the extract has an effect of reducing body fat and cellulite. The cosmetic composition or ointment according to claim 1 or 2, wherein the cosmetic composition is a lotion, gel, water-soluble liquid, cream, essence, oil-in-water (O / W) or water-in-oil (W / O) type formulation. Cosmetic composition, characterized in that selected.