KR101910419B1 - Cosmetic compositions having sebosuppressive effect - Google Patents

Abstract

The present invention relates to a cosmetic composition for inhibiting sebum production. More specifically, the composition of the present invention comprises at least one extract selected from the group consisting of fresh chow, horse chestnut, barnyard herb, and astronomy.
The cosmetic composition for inhibiting sebum production containing the extract of the present invention inhibits the activity of liver X receptor alpha (LXR alpha) and inhibits the sterol regulatory element binding protein -1c involved in sebum production -1c, and SREBP-1c). Thus, it can be used for prevention and treatment of acne due to its excellent effect of inhibiting sebum production, and it can be widely used for hair treatment products for treating seborrheic dermatitis and hair loss prevention products .

Description

{COSMETIC COMPOSITIONS HAVING SEBOSUPPRESSIVE EFFECT}

The present invention relates to a cosmetic composition for inhibiting sebum production, and more particularly to a cosmetic composition for inhibiting sebum production, which comprises at least one plant extract selected from the group consisting of fresh herb, horse mackerel,

The skin consists largely of three layers of epidermis, dermis, and subcutaneous tissue, and it is composed of hair follicles, hair follicles, sebaceous glands, etc., and is responsible for chemical, physical and biological barrier functions. The sebaceous gland is one of the appendages of the skin. It is called the follicular line and the branch line. It is formed by differentiation of the epidermis at the time of birth. It is located in the dermis layer and discharges the lipid through the pore. If the function of the sebaceous gland is activated more than necessary, it becomes oily skin with a large amount of sebum secretion. If the excess sebum is not discharged normally, it develops into acne or causes various skin diseases such as seborrheic dermatitis due to excess sebum. The oily skin is always shiny, the pores are wide and the stratum corneum is thick, so it looks as if the skin is thick, but it does not easily develop wrinkles due to ultraviolet rays and dryness, and does not easily aging.

Acne is a chronic inflammatory disease of the skin adnexa, especially folliculitis. It is also called acne. It is a very common skin disease. It usually starts to appear in puberty and usually disappears in the mid 20s. Men are most frequently encountered between the ages of 16-19 years and women between 14-16 years of age, and severe forms of acne are known to occur more frequently in men. Clinically, it usually appears on face, neck, and chest, which are areas of sebaceous glands, which are cotton, pustules, cysts, nodules and sometimes scarring. The exact cause of acne is not known, but it is known that various symptoms are involved and clinical symptoms are manifested by the interaction of various factors. The major factors that contribute to this pathogenesis are 1) abnormally increased hair follicle wall keratinization and abnormal elimination, 2) increased secretion of sebum induced by androgen, 3) growth of Propionibacterium acne, 4) inflammation induction, 5) inheritance, and 6) hair follicle reactivity.

In order to treat such acne, antibiotics such as tetracycline, erythromycin, and macrocycline have been used to inhibit sebum production using endogenous, to inhibit inflammation by steroid hormones, to use antibiotics such as resorcinol, sulfur and benzoyl peroxide And a method for inhibiting the activity of Propionibacterium acnes bacterium. Recently, treatment methods using vitamin A derivatives such as retinoic acid have been widely used. Although these methods are effective for treating acne, they have side effects in terms of skin safety. The use of hormones has been reported to inhibit the growth of the epidermis and other side effects of hormone abuse. Retinoic acid and benzoyl peroxide have been reported to cause skin irritation and contact dermatitis. Antibiotics such as tetracycline have been shown to cause the appearance of resistant bacteria, The possibility of action is known.

The increase of sebaceous secretion is one of the main causes of acne disease. Testosterone, peroxisome proliferator-activated receptor (PPAR) ligand, α-MSH (alpha-melanocyte stimulating hormone) (Corticotrophin-Releasing Hormone), and IGF (Insulin-Like Growth Factor-1). Recent studies have shown that oxysterol, such as 22 (R) -hydroxycholesterol, activates liver X receptor alpha (LXRα) and increases sebum productionJournal of Investigative Dermatology, 2008; 128 (5): 1266-72). Liver X receptor alpha (LXRα) is a receptor that plays an important role in cholesterol homeostasis by regulating the genes involved in cholesterol transport and neutral lipid synthesis. It is known that fatty acid synthase (FAS) (SREBP-1c), which induces sebum production by activating enzymes such as binding protein-1c (sterol regulatory element binding protein-1c, SREBP-1c).

The present inventors inhibited the activity of liver X receptor alpha (LXRα) and inhibited the expression of sterol regulatory element binding protein-1c (SREBP-1c) involved in sebum production As a result of efforts to develop a cosmetic composition having an excellent sebum production inhibiting effect, it has been found that it contains an extract of at least one plant selected from the group consisting of acanthopanax, The inventor of the present invention has completed the invention of a cosmetic composition which is safe for human body and has no side effects even when it is used for a long time.

The present invention relates to a cosmetic composition for inhibiting sebum production, and more particularly to a cosmetic composition for inhibiting sebum production, which comprises at least one plant extract selected from the group consisting of fresh herb, horse mackerel,

In one embodiment of the present invention, there is provided a cosmetic composition for inhibiting sebum production, which comprises at least one plant extract selected from the group consisting of fresh herb, horse mackerel, barnyard herb, and astronomy.

The fresh chestnut, horse chestnut, barnyard grass or snake root is contained in an amount of 0.001 to 10% by weight with respect to the total weight of the composition, and the fresh chestnut, horse mackerel, barnyard grass or astrophysicose has activity of liver X receptor alpha (LXRα) And has the effect of inhibiting the expression of the sterol regulatory element binding protein-1c (SREBP-1c).

In one embodiment of the present invention, the cosmetic composition is one or more kinds selected from the group consisting of lotion, gel, water-soluble liquid, cream, essence, shampoo, oil-in-water (O / W) Or more.

In one embodiment of the present invention, the at least one plant extract selected from the group consisting of the fresh herb, horse mackerel, millet, and astrocanthan is extracted with water, an organic solvent or a mixture thereof, and the organic solvent is anhydrous methanol , Ethanol, propyl alcohol, butyl alcohol, glycerin, propylene glycol, and butylene glycol.

The composition of the present invention inhibits the activity of liver X receptor alpha (LXR alpha) and the expression of sterol regulatory element binding protein-1c (SREBP-1c) involved in sebum production To inhibit sebum production.

The composition of the present invention is safe to the human body including a plant derived from natural origin with little irritation to the skin and has no side effects even if it is used for a long period of time and can be formulated into various formulations.

The cosmetic composition for inhibiting skin sebum formation according to the present invention is characterized by a cosmetic composition containing at least one extract selected from the group consisting of acanthopanax,

The active ingredients of the cosmetic composition of the present invention are as follows: Chinese herb, Korean horse mackerel,

Angelica Utilis Makino ) is a perennial herb that belongs to the falciparum family. It is often called "asiura" or "Shinchigoso" in Japan and "hencho" in China. If you break the stem of the kyunchok, yellow juice comes out, and the chalcone and coumarin, which are contained in this juice, have an effect of suppressing the cancer. It is used in the treatment of diabetes because of the hypoglycemic effect, and has the effect of removing cholesterol and normalizing the blood pressure without lowering or increasing the blood pressure unconditionally, and thus has an excellent effect on arteriosclerosis, hypertension and hypotension. In addition, organic germanium and chlorophyll help oxygen supply to the cells and improve blood circulation, thus helping to prevent and treat anemia and prevent congestion (鬱 血).

Equisetum arvense L. ) belongs to the genus Euphorbia, and it reproduces as long ago as the unsprayed spores. The main habitat is moist sandy soil, and in the west, it is called horsetail because horsetail is represented by horsetail with stratified twigs. In Korea, it is known as horsetail because it feeds well. It is a perennial plant that grows frequently in sunny meadows. It grows long and roots in the ground. The reproductive stem comes out in early spring. When the reproductive stem starts to grow, a nutrient stem comes out. The end of the reproductive stem looks like a brush head. The spore is spread from here when it is summer, and the nutrient stem grows at the time when the reproductive stem grows. It stands straight and is green with 30 ~ 40cm in height and has nodes and ridges. Scaly leaf is turned on the node and branches are split. . The reproductive stem of the horse is edible, and has been widely used as a diuretic in the private sector since ancient times.

Lysimachia vulgaris there is . davurica ( Ledeb .) R. Kunth ) is a perennial plant belonging to the primate family. The rootstock grows as it extends to the side, and the main stem is 40-80㎝ high. Leaves run in opposite directions, 3-4 turns, lanceolate or ovate, with flat edges and black spots. Flowers bloom in June-August, yellow and hang on cones. The fruit is round and calyx remains. In one room, the roots are called Huang 甘 菜, and in China, it is called Huang Yan flower. In the private sector, outposts are used for gastrointestinal diseases, hemorrhoids, hemorrhoids, diarrhea, gastric ulcers, and sore throat.

Asparagus cochinchinensis is a perennial herbaceous plant belonging to the Liliaceae family. Its stem is 1 ~ 2m long and it grows and has many branches with a line shape. Leaves are needle-like lanceolate. The fruit is round and whitish and grows in the coastal zone of central and southern China. The roots of the roots are called astronomical roots, and in the fall, the roots are peeled off and steamed. It is said that this plant is similar to Maeummundong because it is vine. In Han, it is used for nourishing tonic medicine, cough medicine for cough and sputum caused by vulgaris, and hardening of mutation.

The extract of at least one selected from the group consisting of the fresh herb, horse mackerel, mackerel, and astronomy can be contained in an amount of 0.001 to 10 parts by weight based on the composition. When the extract is contained in an amount of less than 0.001 part by weight, the effect of inhibiting sebum production may be insignificant. When the extract is contained in an amount exceeding 10 parts by weight, the stability of the formulation may be deteriorated.

The extracts of chrysanthemum chinensis, chrysanthemum chrysanthemum, chrysanthemum chrysanthemum, and chrysanthemum mud can be obtained by pulverizing chrysanthemum chrysanthemum, horse chestnut, molluscum, and chrysanthemum root outpowder respectively and extracting a hydrophilic organic solvent such as methanol or ethanol or a mixed solution of hydrophilic organic solvent and water as extraction solvent, Followed by stirring at an appropriate time interval while immersing the solution, and recovering the obtained solution by filtration.

As a preferable extraction solvent, one pure solvent selected from the group consisting of anhydrous or containing methanol having 1 to 4 carbon atoms, a solvent group containing ethanol, propyl alcohol, butyl alcohol, glycerin, propylene glycol and butylene glycol, A combined mixed solvent may be used, and the amount of the extraction solvent to be added to the plant material may be about 1 to 50 times the total volume of the plant material.

More preferably, the extraction solvent for extracts of Japanese apricot, horsetail, barnyard grass, and astringent root of the present invention is a pure solvent selected from anhydrous methanol, hydrated methanol, anhydrous ethanol and hydrated ethanol, or one of the methanol and one of the ethanol Is preferably used.

At this time, the amount of the extraction solvent added is preferably 5 to 20 ml per 1 g of the dry weight of the chrysanthemum, horsetail, barnyard grass, and heavenly mussel. A conventional method of extracting the solvent by a conventional method such as a method of immersing in water at room temperature for 1 to 7 days or a method of heating at 50 to 95 ° C for 1 to 5 hours.

The cosmetic composition containing at least one plant extract selected from the group consisting of fresh herb, horse mackerel, barnyard herb, and astrobiant is selected from the group consisting of lotion, gel, water-soluble liquid, cream, essence, shampoo, oil-in- / O) type formulation.

Hereinafter, the present invention will be described in more detail with reference to the following examples and experimental examples. However, these examples and experimental examples are provided only for the understanding of the present invention, and are not intended to limit the scope of the present invention.

Manufacturing example  1. Preparation of chrysanthemum extract

The fresh goat was pulverized and pulverized, and then 80% ethanol was added to the volume of about 2 times as much as the fresh goat's milk. After cooling for 3 days, all the solution was collected and filtered with a filter paper. The solvent was removed using an evaporator, And dried for more than 48 hours to obtain a powdery state.

Manufacturing example  2. Manufacture of extract

The mixture was pulverized and pulverized, and then 80% ethanol was added to the solution in an amount of about twice the volume of the extract. After cooling for 3 days, the solution was collected and filtered through a filter paper. The solvent was removed using an evaporator and dried in a freeze dryer And dried for more than 48 hours to obtain a powdery state.

Manufacturing example  3. Manufacture of mulberry extract

Pulverized wheat flour was pulverized and pulverized. Then, 80% ethanol was added twice as much as the amount of wheat flour for 3 days. After cooling for 3 days, the solution was collected and filtered with filter paper. The solvent was removed using an evaporator and dried in a freeze dryer And dried for more than 48 hours to obtain a powdery state.

Manufacturing example  4. Chunmun Dong  Extract preparation

After cooling, the solution was collected by filtration through a filter paper, the solvent was removed using an evaporator, and dried in a freeze dryer. And dried for more than 48 hours to obtain a powdery state.

Experimental Example  1. Experiment on inhibition of sebum production

The mesenchymal cells were cultured in DMEM / F-12 (1: 1) supplemented with 10% FBS and incubated for 2 days with 5 × 10 ³ cells attached to a 96-well plate. After induction of sebum production with 22 (R) -hydroxycholesterol (200 nM), the extracts were further cultured for 2 days. After washing with PBS buffer, the lipids in the cells were stained with nile red reagent, and fluorescence intensity was measured at excitation 485 nm and emission 565 nm using a multifunctional enzyme immunoassay. It is known that the fluorescence intensity measured is proportional to sebum production. Table 1 shows the fluorescence intensity ratios of the untreated group.

Fluorescence intensity ratio (%) Non-treated group (control) 100 22 (R) -hydroxycholesterol (200 nM) 160 22 (R) -hydroxycholesterol (200 nM) + chrysanthemum extract 0.001% 148 22 (R) -hydroxycholesterol (200 nM) + chrysanthemum extract 0.1% 125 22 (R) -hydroxycholesterol (200 nM) + Rhizome extract 0.001% 146 22 (R) -hydroxycholesterol (200 nM) + Rhizome extract 0.1% 115 22 (R) -hydroxycholesterol (200 nM) + bastille extract 0.001% 150 22 (R) -hydroxycholesterol (200 nM) + bastille extract 0.1% 125 22 (R) -hydroxycholesterol (200 nM) + astroglutamic acid extract 0.001% 140 22 (R) -hydroxycholesterol (200 nM) + astroglutamic acid extract 0.1% 110 22 (R) -hydroxycholesterol (200 nM) + fresh chrysanthemum, 137 22 (R) -hydroxycholesterol (200 nM) + fresh chinese, 105

As shown in the above Table 1, lipid production was significantly increased when 22 (R) -hydroxycholesterol was added, and it was confirmed that the production of intracellular sebum was decreased when chrysanthemum chinensis, Therefore, it can be seen that the extracts of chrysanthemum, rhizome, mulberry, and astrobiantus reduce sebum production by 22 (R) -hydroxycholesterol.

Experimental Example  2. Liver X receptor alpha LXR α) as an inhibitory effect

Liver X receptor alpha (LXRα) is a receptor that plays an important role in cholesterol homeostasis by regulating genes involved in cholesterol transport and neutral lipid synthesis. It is induced by 22 (R) -hydroxycholesterol stimulation in sebaceous cells Activity, and increases sebum production. Therefore, the inhibitory effect of LXRα on hepatic X receptor alpha in extracts of chrysanthemum, rhizome, mungbean, and astringent dong were confirmed by the following experiments.

The cells were cultured in a 6-well plate at a concentration of 10 ⁵ for 48 hours, and treated with 200 nM of 22 (R) -hydroxycholesterol, chrysanthemum morifolium, mung bean, mallow, and celadon root extract. After 30 minutes of extract treatment, the cells were collected and total RNA was extracted. Reverse transcription-PCR (RT-PCR) was performed on the mRNA of liver X receptor alpha (LXR?) To determine the expression level of the liver X receptor alpha .

Liver X receptor alpha (LXRα) gene expression ratio (%) Untreated group (negative control group) 100 22 (R) -hydroxycholesterol (200 nM) 180 22 (R) -hydroxycholesterol (200 nM) + chrysanthemum extract 0.1% 130 22 (R) -hydroxycholesterol (200 nM) + Rhizome extract 0.1% 125 22 (R) -hydroxycholesterol (200 nM) + bastille extract 0.1% 130 22 (R) -hydroxycholesterol (200 nM) + astroglutamic acid extract 0.1% 120 22 (R) -hydroxycholesterol (200 nM) + fresh chinese, 120

When treated with 22 (R) -hydroxycholesterol, the ratio of liver X receptor alpha (LXRα) gene expression was increased by 180% as compared to the untreated group, and when treated with chrysanthemum, Alpha (LXR [alpha]) gene expression was decreased. This study confirmed the inhibitory effect of extracts of Xanthomonas sp.

Experimental Example  3. Gansterol Regulatory factor Binding protein -1c ( SREBP - 1c)

The sterol regulatory element binding protein-1c (SREBP-1c) is one of the enzymes involved in lipid metabolism and is expressed by 22 (R) -hydroxycholesterol in sebaceous cells. Thus, the inhibitory effect of the Sterol regulator binding protein-1c (SREBP-1c) on the expression of Chinese herbal extracts, Rhizopus sp.

The sebaceous gland cells were cultured for 48 hours in a 6-well plate at a concentration of 10 ⁵ , and treated with 200 nM of 22 (R) -hydroxycholesterol and chrysanthemum morifolium, Rhododendron spp. After 30 minutes of extract treatment, the cells were collected and the total RNA was extracted and reverse transcription PCR (RT-PCR) was performed on the mRNA of sterol regulatory factor binding protein-1c (SREBP-1c) to obtain sterol regulatory factor binding protein- -1c) gene was confirmed.

Sterol regulatory factor binding protein-1c (SREBP-1c) gene expression ratio (%) Untreated group (negative control group) 100 22 (R) -hydroxycholesterol (200 nM) 190 22 (R) -hydroxycholesterol (200 nM) + chrysanthemum extract 0.1% 125 22 (R) -hydroxycholesterol (200 nM) + Rhizome extract 0.1% 130 22 (R) -hydroxycholesterol (200 nM) + bastille extract 0.1% 120 22 (R) -hydroxycholesterol (200 nM) + astroglutamic acid extract 0.1% 120 22 (R) -hydroxycholesterol (200 nM) + fresh chinese, 125

When treated with 22 (R) -hydroxycholesterol, the ratio of sterol regulatory factor binding protein-1c (SREBP-1c) gene expression was increased by 190% compared to the untreated group, and treated with chrysanthemum, 1c (SREBP-1c) gene expression ratio was decreased in the case of SLEBP-1c. The inhibitory effect of S-selectin-1c (SREBP-1c) on the inhibition of sterol regulatory factor binding protein of chrysanthemum, beetle,

Experimental Example  4. Safety test for skin

A human patch test was performed to evaluate the degree of irritation to the skin. The skin patch test was performed on 20 normal healthy persons aged 20 years or older. The sample was made into 1% and 10% aqueous solution, then attached to the inside of the upper abdomen for 48 hours by using a Finn chamber, After 72 hours, secondary readings were performed to determine skin reaction results. The evaluation criteria and the stimulation index are shown in Table 4 below and the results are shown in Table 5.

reaction weight Evaluation standard - 0.0 No reaction ± 0.5 Suspicious Positive Response + 1.0 Weakly positive reaction ++ 2.0 Strong positive reaction +++ 3.0 Polar positive reaction

(2)

Skin irritation index = Σ (number of weighted X responses) / (maximum weighted X total number of subjects) × 100

Skin irritation index Degree of stimulation Chrysanthemum extract (1%) 0.0 No stimulation Corn extract (1%) 0.0 No stimulation Bullwhip extract (1%) 0.0 No stimulation Chunmun Dong extract (1%) 0.0 No stimulation Chrysanthemum morifolium, Rhododendrons, Milkweed, Chunmun-dong extract (1%) 0.4 No stimulation Chrysanthemum morifolium, Chrysanthemum morifolium, Milkweed, Chunmun-dong extract (10%) 0.8 No stimulation

As a result, it was found that no less than 10% of the extracts of Kwangseop, Kwangseong, Hanwolpyeong, and Chunmunmodong showed no irritation to the skin.

Experimental Example  5. Prevention of sebum production and improvement of acne Clinical trial

The cream compositions of Examples 1 to 5 and Comparative Example 1 were prepared with the composition shown in Table 6 below (unit: wt%).

Ingredients Content (% by weight) Comparative Example 1 Example One 2 3 4 5 Chrysanthemum extract - 1.0 - - - 0.25 Corn extract - - 1.0 - - 0.25 Mallow extract - - - 1.0 - 0.25 Chunmun-dong extract - - - - 1.0 0.25 glycerin 5.0 5.0 5.0 5.0 5.0 5.0 Stearic acid 8.0 8.0 8.0 8.0 8.0 8.0 Squalane 5.0 5.0 5.0 5.0 5.0 5.0 Self emulsifying glycerin monostearate 2.5 2.5 2.5 2.5 2.5 2.5 Polyoxyethylene sorbitan monostearate 1.5 1.5 1.5 1.5 1.5 1.5 Propylene glycol 4.0 4.0 4.0 4.0 4.0 4.0 Stearyl glycyrrhetinate 0.2 0.2 0.2 0.2 0.2 0.2 vaseline 2.0 2.0 2.0 2.0 2.0 2.0 Antioxidant Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount antiseptic Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Purified water Balance Balance Balance Balance Balance Balance

Clinical trials were conducted to confirm the effect of the cream prepared in Comparative Example 1 and Examples 1 to 5 on sebum production inhibition and acne improvement effect. The subjects were 30 acne patients with acne lesions, and they were used for 4 weeks after morning and evening cleansing twice a day.

The amount of sebum secretion was measured using a sebumeter (Courage + Khazaka, Cologne, Germany). This device was used to contact the film for 30 seconds at a constant pressure using liposomes Measure the light intensity and measure the degree of lipid easily. The amount of sebum secretion before and after use was measured, and the inhibition rate (%) of sebum production was calculated by the following equation, and the results are shown in Table 7.

(1)

% Inhibition of sebum production (%) = (pre-use amount of sebum - amount of used amount of use) / amount of pre-use amount of X 100

% Inhibition of sebum production (%) Comparative Example 1 5 Example 1 20 Example 2 22 Example 3 18 Example 4 20 Example 5 23

As a result, sebum production was decreased compared with Comparative Example 1 when Examples 1 to 5 containing kelp, kelp, mugwort, and mulberry extract were used for 4 weeks.

In order to confirm the improvement effect of acne, total number of lesions of inflammatory acne of non-inflammatory acne and inflammatory papules, pustules, and nodules before and after use and after use were observed by photographs and the results are shown in Table 8.

Inflammatory Acne Reduction Rate (%) Non-inflammatory acne reduction rate (%) Comparative Example 1 20 15 Example 1 60 65 Example 2 55 70 Example 3 50 60 Example 4 60 65 Example 5 65 70

As a result of the experiment, it was confirmed that when Examples 1 to 5 containing the herbal extracts of Kwangju, Kwangseo, Narcissus, and Astragalus were used for 4 weeks, both inflammatory acne and non-inflammatory acne were improved as compared with Comparative Example 1.

Based on the results of the above-described experimental examples, various formulation examples using fresh chinese herb, horse chestnut, Narcissus spp., And Chunmunmdong extract are prepared and presented. However, it should be apparent to those skilled in the art that these formulation examples are for illustrating the present invention and that the formulation of the present invention is not limited to these formulation examples.

Formulation Example  1. Flexible lotion ( skin toner )

Ingredients Content (% by weight) Chrysanthemum extract 0.25 Corn extract 0.25 Mallow extract 0.25 Chunmun-dong extract 0.25 glycerin 5.0 1,3-butylene glycol 3.0 ethanol 5.0 Polyoxyethylene nonylphenyl ether 0.5 Spices Suitable amount antiseptic Suitable amount Purified water Balance

Formulation Example  2. convergent lotion ( astrigent )

Ingredients Content (% by weight) Chrysanthemum extract 0.25 Corn extract 0.25 Mallow extract 0.25 Chunmun-dong extract 0.25 glycerin 3.0 Citric acid 0.1 ethanol 10.0 Polyoxyethylene oleyl ether 1.0 Sorbitol 2.0 Spices Suitable amount antiseptic Suitable amount Purified water Balance

Formulation Example  3. Lotion ( emulsion )

Ingredients Content (% by weight) Chrysanthemum extract 0.25 Corn extract 0.25 Mallow extract 0.25 Chunmun-dong extract 0.25 glycerin 5.0 1,3-butylene glycol 8.0 Squalane 10.0 Polyoxyethylene sorbitan monooleate 2.0 Triethanolamine 1.5 Glyceryl stearate 0.5 Stearyl glycyrrhetinate 0.2 Carboxyvinyl polymer 0.1 Arginine 0.1 Spices Suitable amount antiseptic Suitable amount Purified water Balance

Formulation Example  4. Cream ( cream )

Ingredients Content (% by weight) Chrysanthemum extract 0.25 Corn extract 0.25 Mallow extract 0.25 Chunmun-dong extract 0.25 glycerin 5.0 Stearic acid 8.0 Squalane 5.0 Self emulsifying glycerin monostearate 2.5 Polyoxyethylene sorbitan monostearate 1.5 Propylene glycol 4.0 Stearyl glycyrrhetinate 0.2 vaseline 2.0 Antioxidant Suitable amount Spices Suitable amount antiseptic Suitable amount Purified water Balance

While the present invention has been described with reference to exemplary embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. You will know. In addition, many modifications may be made to adapt a particular situation and material to the teachings of the invention without departing from the essential scope thereof. Accordingly, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention be construed as including all embodiments falling within the scope of the appended claims.

Claims (7)

A cosmetic composition for inhibiting the production of sebum comprising a fresh persimmon extract. The method according to claim 1,
Wherein the fresh persimmon is contained in an amount of 0.001 to 10% by weight based on the total weight of the composition. The method according to claim 1,
The cosmetic composition for inhibiting sebum production, wherein the fresh persimilis has an effect of inhibiting the activity of liver X receptor alpha (LXR alpha). The method according to claim 1,
Wherein the herbal composition has an effect of inhibiting the expression of sterol regulatory element binding protein-1c (SREBP-1c). The method according to claim 1,
Wherein the cosmetic composition is at least one formulation selected from the group consisting of lotion, gel, water-soluble liquid, cream, essence, shampoo, oil (O / W) and water (W / O) (2). The method according to claim 1,
The cosmetic composition for inhibiting sebum formation, wherein the herbal extract is extracted with water, an organic solvent or a mixture thereof. The method according to claim 6,
Wherein the organic solvent contains at least one selected from the group consisting of anhydrous methanol having 1 to 4 carbon atoms, ethanol, propyl alcohol, butyl alcohol, glycerin, propylene glycol and butylene glycol .