KR20110110574A - Composition for improving study skills - Google Patents

Abstract

The present invention relates to a composition for improving learning ability, and more particularly, by containing a complex extract or a fermented product thereof composed of Angelica, Macmundong, Baeksin, Saenghwanghwang, Baekchul, Baekshou, Ganoderma lucidum and jujube extract as an active ingredient. In addition, the present invention relates to a composition for improving learning ability that can improve concentration or cognitive ability. In addition, the present invention relates to a composition for enhancing learning ability, which further comprises red ginseng extract or its fermented product together with the complex extract or fermented products thereof.

Description

Composition for improving study skills

The present invention relates to a composition for improving learning ability, and more particularly, by containing a complex extract or a fermented product thereof composed of Angelica, Macmundong, Baeksin, Saenghwanghwang, Baekchul, Baekshou, Ganoderma lucidum and jujube extract as an active ingredient. In addition, the present invention relates to a composition for improving learning ability that can improve concentration or cognitive ability. In addition, the present invention relates to a composition for enhancing learning ability, which further comprises red ginseng extract or its fermented product together with the complex extract or fermented products thereof.

Learning ability, including memory, is a central process that is critical to the daily lives and activities of modern people. It is a concentration, short term memory, working memory, long term memory, and reasoning. A series of mental processes, such as exercise control and work planning, are inherent and ultimately affect the quality of life as it directly affects our ability to work intelligently every day. It is believed that oxidative stress in the brain forms plaques, which cause inflammatory responses, leading to brain deterioration. This has been confirmed by recent studies of dementia and forgetfulness (ALZHEIMER'S DISEASE AND OXIDATIVE STRESS: IMPLICATIONS FOR NOVEL THERAPEUTIC APPROACHES, Neurobiology vol. 57, pp 301-323, 1999).

On the other hand, increasing the amount of acetylcholine in the body increases the muscarin (muscarine) effect improves memory and cognition. Acetylcholine in the brain is produced in the brain neurons by an enzyme called choline acetyltrasferase, released into the synaptic cleft, and then cholinergic to the acetylcholine receptors of neurons (postsynaptic neuron). neurotransmission, which is regulated by acetylcholinesterase (AChE) in the synaptic interval, and inhibiting the action of acetylcholinease can prevent the breakdown of acetylcholine to maximize the amount of acetylcholine available. Cholinergic transmission is increased to improve cognitive abilities, such as memory.

Until now, drugs used for improving memory and learning ability include derivatives of gamma-aminobutyric acid, acetylcholine precursor, and receptor agonist, which increase metabolic rate of the central nervous system. ) And nicotine have been developed, and tacrine and aricept, donepezil, which improve the cognitive function by preventing the degradation of neurotransmitters, have been developed.

Therefore, the present inventors have tried to find a natural substance to prevent plaque formation due to oxidative stress and to treat or prevent brain degradation through this, and as a result, Angelica sinensis, Macmundong, Baeksin, Saenghwanghwang, Baekchul, Baekshou, Ganoderma lucidum and jujube extract When the composite extract or the fermented product thereof as an active ingredient is contained, the present invention has been found to prevent the formation of plaque due to oxidative stress in the human body, thereby improving memory, concentration or cognitive ability.

In addition, the present inventors confirmed that the red ginseng extract or its fermented product together with the complex extract further improves memory, concentration or cognitive ability.

Accordingly, it is an object of the present invention to provide a composition for enhancing safe memory, concentration, cognitive ability or learning ability without side effects.

In order to achieve the above object, in the present invention, for improving memory, concentration, cognitive ability or learning ability containing a complex extract consisting of Angelica, Macmundong, Baiboksin, raw yellow sulfur, Baekchul, Baekshao, Ganoderma lucidum and jujube extract as an active ingredient To provide a composition.

In another aspect, the present invention provides a composition for enhancing memory, concentration, cognitive ability or learning ability further containing the red ginseng extract or its fermented product together with the complex extract or fermented product.

The composition according to the present invention was excellent in the antioxidant effect of protecting the brain from oxidative stress, which lowers the function of the brain, inhibited acetylcholine degradation, and improved event memory and spatial perception.

1 is a graph showing the antioxidant efficacy of the composite extract and its fermentation according to the present invention.
Figure 2 is a graph showing the inhibitory ability of acetylcholine degradation of the composite extract and its fermentation according to the present invention.
Figure 3 is a graph showing the effect of improving the event memory of the complex extract and its fermentation according to the present invention (+: p <0.05 level of significance compared to the control, *: p <0.05 level of significance compared to the control group , #: Have a significance level of p <0.01 compared to the control).
Figure 4 is a graph showing the spatial perceptual improvement effect of the composite extract and its fermentation according to the present invention (+: p <0.1 level of significance compared to the control, #: p <0.05 compared to the control level of significance ).
5 is a graph showing the effect of activating the brain cells of Examples 1 to 4 according to the present invention (*: P <0.005) [A: 50 ppm treatment of Example 1, B: 5 ppm treatment of Example 1 One group, C: 50 ppm treated Example 2, D: 5 ppm treated Example 2, E: 50 ppm treated Examples 1 and 3, F: Example 1 and Examples 5 ppm of Example 3, G: 50 ppm of Examples 2 and 3, and H: 5 ppm of Examples 2 and 3.].

The present invention is to enhance the learning ability to improve memory, concentration or cognitive ability by containing a complex extract consisting of Angelica, Macmundong, Baekshinsin, raw dried sulfur, Baekchul, Baekshou, Ganoderma lucidum and jujube extract as an active ingredient. It relates to a composition for.

The complex extract may be prepared by extraction with water or ethanol by a method well known in the art alone or in a mixture of two or more of the natural products, preferably using water. At this time, the extraction temperature is preferably 10 ~ 90 ℃, it can be extracted for 4 to 24 hours. If the extraction temperature and extraction time is out of the extraction efficiency may decrease or change of components may occur.

In addition, the fermented product of the complex extract may be processed by the conventional fermentation method of the complex extract. For example, useful fermentation strains known in the art, such as lactic acid bacteria, yeast bacteria can be used. In this case, before the complex extract is prepared, the strain may be directly inoculated with the natural product, followed by fermentation to extract the fermented product, or the fermented strain may be inoculated with the complex extract to obtain fermented product. At this time, the fermentation conditions may be fermented for 30 hours to 60 hours at 20 ℃ to 50 ℃, for example, may be fermented for 40 to 50 hours at 30 ℃ to 40 ℃, preferably 42 to 48 hours at 37 ℃ Can be prepared by fermentation.

The composition for enhancing learning strength according to the present invention preferably contains 10 to 90% by weight of the complex extract or fermented product thereof, and when the content is less than 10% by weight, desired efficacy cannot be obtained. The optimum effect can be obtained at 90 wt% or less.

In addition, the present invention relates to a composition for enhancing learning ability, which further comprises red ginseng extract or its fermented product together with the complex extract or fermented products thereof. Red ginseng extract used in the present invention is prepared by ultra-high pressure extraction.

The red ginseng extract used in the present invention may be one of a conventional ultra high pressure treatment method. For example, the ultrahigh pressure treatment may be one minute to 30 minutes ultra high pressure treatment of red ginseng at a pressure of 100 to 600 Mpa or more. Preferably, the treatment can be performed for 1 to 10 minutes, but is not limited thereto.

 In addition, the red ginseng extract used in the present invention may be processed in the same manner as a conventional fermentation method or a fermentation process of the complex extract. For example, useful fermentation strains known in the art, such as lactic acid bacteria, yeast bacteria can be used. In this case, the seed may be directly inoculated with the red ginseng and then fermented to obtain an extract, or the fermented product may be obtained by inoculating the fermented strain with the red ginseng extract.

The composition for enhancing learning strength according to the present invention preferably contains 10 to 90% by weight of the red ginseng extract or its fermented product, and when the content is less than 10% by weight, the desired efficacy cannot be obtained. The optimum effect can be obtained at 90 wt% or less.

The composition for enhancing learning strength according to the present invention is not particularly limited in its formulation, but may be, for example, a pharmaceutical composition or a health food composition.

When the composition according to the present invention is a pharmaceutical composition, it may be used by formulating in the form of powder, granules, tablets, capsules, suspensions, emulsions, oral formulations, etc. according to conventional methods.

Moreover, 1 type (s) or 2 or more types of the following additives can be added and mix | blended with the said composition as needed. As said additive, For example, various fruit juices, such as grapefruit, an apple, an orange, a lemon, a pineapple, a banana, a pear, may be concentrated juice, powder juice, etc .; Vitamins (remicol retinol, riboflavin, pyridoxine, cyanocobalamine, sodium ascorbate, nicotinic acid amide, calcium pantothenate, folic acid, biotin, cholecalciferol, cholinergic tartaric acid, choline, tocopherol or β Water-soluble and fat-soluble vitamins such as carotene); Flavors (lemon flavors, orange flavors, tali flavors, grapefruit flavors or vanilla essences, etc.); Amino acids, nucleic acids and salts thereof (glutamic acid, sodium glutamate, glycine, alanine, aspartic acid, sodium aspartate, inosinic acid, etc.); Plant fibers (polydextrose, pectin, xanthan gum, glucomannan or alginic acid, etc.); Or minerals (sodium chloride, sodium acetate, magnesium sulfate, potassium chloride, magnesium chloride, magnesium carbonate, calcium chloride, dipotassium phosphate, monosodium phosphate, calcium glycophosphate, ferrous citrate, ammonium ferric citrate, iron citrate, manganese sulfate, Copper sulfate, sodium iodide, potassium sorbate, zinc, manganese, copper, iodine or cobalt, and the like.

The composition may further contain pharmaceutical adjuvants such as preservatives, stabilizers, emulsifiers or emulsifiers, salts and / or buffers for the control of osmotic pressure and other therapeutically useful substances, and various oral forms according to conventional methods. It can be formulated as.

Formulations for oral administration include, for example, tablets, pills, hard and soft capsules, solutions, suspensions, emulsifiers, syrups, granules, etc. These formulations may contain diluents (e.g., lactose, dextrose, sucrose, etc.) in addition to the active ingredients. , Mannitol, sorbitol, cellulose and glycine), lubricants such as silica, talc, stearic acid and its magnesium or calcium salts and polyethylene glycols. Tablets may further contain binders such as magnesium aluminum silicate, starch paste, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose and polyvinylpyrrolidine, optionally starch, agar, alginic acid or its sodium salt Pharmaceutical additives such as disintegrants, absorbents, colorants, flavors, and sweeteners. Tablets may be prepared by conventional mixing, granulating or coating methods.

In addition, when the composition according to the present invention is a health food composition, for example, it can be formulated into various foods, beverages, gums, teas, vitamin complexes or health functional foods. The complex extract, red ginseng extract and their fermented products used in the present invention have little toxicity and side effects, and therefore can be used safely even when taken for a long time.

The health food composition of the present invention is not particularly limited to other ingredients except for containing the complex extract, red ginseng extract and their fermented products as essential ingredients in the indicated ratios, and various flavors or natural carbohydrates are added as in general beverages. It may contain as a component. Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And conventional sugars such as polysaccharides such as dextrin, cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The proportion of natural carbohydrates is generally about 1-20 g, preferably about 5-12 g per 100 ml of the composition of the present invention.

In addition to the above, the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and salts thereof. , Organic acids, protective colloidal thickeners, pH adjusters, stabilizers, carbonation agents used in alcoholic or carbonated beverages, and the like. The compositions of the present invention may also contain pulp for the production of natural fruit juices and fruit juice beverages and vegetable beverages. These components can be used independently or in combination. The proportion of such additives is not so critical but is usually chosen in the range of 0 to 20% by weight, based on the total weight of the composition of the present invention.

Dosage of the complex extract, red ginseng extract and their fermentation may be defined within the range of those skilled in the art, the daily dose of the composition according to the present invention is less than the progression, onset time, age, Depending on various factors such as health conditions, complications, etc., on the basis of 45 kg of adolescents, 1 to 100 mg / kg, preferably 10 to 30 mg / kg, of the composition is generally used in combination It may be administered in 1 to 2 divided doses, the dosage does not limit the scope of the invention in any way.

Hereinafter, the present invention will be described more specifically with reference to examples and test examples. These examples are provided only for understanding the contents of the present invention, and the scope of the present invention is not limited to these examples, and modifications, substitutions, and insertions commonly known in the art may be performed. This is also included in the scope of the present invention.

Example 1 Complex Extract Preparation

Washed 2,500 g of the herbal mixture consisting of 9.5% by weight, 9.5% by weight of Macmundong, 9.5% by weight of Baeksin, 14.3% by weight of raw yellow grass, 14.3% by weight of white rice, 14.3% by weight of Baek Sewage, 14.3% by weight of ganoderma lucidum and 14.3% by weight of jujube Then, put into purified water of 7 times (weight ratio), and refluxed for 4 hours at 90 ℃. The mixture was cooled to 40 ° C., and the residue and the filtrate were separated by filtration and centrifugation. The separated filtrate was concentrated under reduced pressure (50 Brix) and sterilized at 90 ° C. for 20 minutes to obtain a composite extract.

Example 2 Preparation of Fermented Product of Complex Extract

After preparing a culture solution to the Brix 20 in 33% to 40% of the complex extract prepared in Example 1 and 60 to 67% of purified water, proceed to 1.2 kg / ㎠ steam pressure sterilization at 121 ℃ 30 minutes, then cooled to room temperature So Lactobacillus Plantarum was inoculated in an appropriate amount (5%) and incubated for 48 hours at 37 ℃. The culture solution was centrifuged at 10,000 rpm or more to remove the cells and insoluble solids, and only the aqueous filtrate was recovered. The filtrate was concentrated to a sugar content of 50 or more using a reduced pressure concentrator to obtain a fermentation product of the complex extract.

Example 3 Preparation of Red Ginseng Concentrate

After extracting by applying ultra high pressure to 1 kg of fresh ginseng at a pressure of 500 Mpas, the residue and the filtrate were separated by filtration and centrifugation, and the filtrate was concentrated under reduced pressure to obtain 600 ~ 700 g of red ginseng concentrate.

Example 4 Fermentation of Red Ginseng Extract

The red ginseng extract prepared in Example 3 was inoculated with lactic acid bacteria and then fermented at 30 ° C. for 120 hours to obtain a red ginseng fermented product.

Test Example 1 Antioxidant Effect Through Reactive Oxygen Scavenging Ability

First, in order to confirm whether the complex extract or the fermented product thereof according to the present invention has an effect of preventing a decrease in brain function caused by oxidative stress, an antioxidant effect through the ability to remove free radicals was confirmed in vitro.

The free radical scavenging activity test, which can recognize the antioxidant effect, uses a chemically stable free radical, DPPH (2,2-Diphenyl-1-picrylhydrazyl), which has a maximum absorbance at around 515-520 nm, When it encounters a substance, DPPH disappears and changes color while giving off electrons. Chemically stable DPPH can analyze the antioxidant effects of extracts, beverages, oils and pure phenolic compounds with various antioxidants. Since these substances oxidize excessively and cause inflammatory reactions, they can be predicted to decrease in activity in the brain if they react with the test substance and reduce activation.

First, 50 μl of DPPH solution, 10 μl of test substance of Examples 1 and 2, and 40 μl of ethanol were added and mixed per well. The DPPH solution was prepared by dissolving DPPH in anhydrous ethanol and diluting the absorbance at a concentration of 0.96 to 0.9 at 540 nm. The test substances of Examples 1 and 2 were 50 mg / ml, 5 mg / ml and 0.5 mg in ethanol, respectively. Diluted to / ml concentration and used. Experimental results were confirmed by measuring the absorbance of 540 nm using an ELISA machine, the results are shown in FIG. Each item is expressed as a numerical ratio compared to the control without treatment of the test substance.

In the results of Figure 1, when the treatment of Examples 1 and 2 according to the present invention was confirmed that the DPPH scavenging activity is increased, especially when the test material is treated 5 mg / ㎖ or more confirmed that the antioxidant efficacy is significantly increased It was.

Test Example 2 Inhibition of Acetylcholine Degradation

In order to find out whether the complex extract according to the present invention or fermented products thereof can improve memory and recognition ability by inhibiting acetylcholine degradation, 50 μl substrate solution, 10 μl enzyme per well, Example 1 and 10 μl of test substance 2 and 30 μl of phosphate solution (PBS) were added and mixed. The substrate solution was prepared by mixing DTNB, acetylthiocholine and phosphate solution. The enzyme was used to separate and extract acetylcholine degrading enzyme (AChE) in the brain with a phosphate solution. Were tested at 50 mg / ml, 5 mg / ml and 0.5 mg / ml, respectively, and the experimental results were measured at an absorbance of 405 nm, and the results are shown in FIG. 2. The inhibitory activity (%) of acetylcholine degradation of the test substances was expressed as a numerical ratio compared to the control which was not treated with the test substance.

In the results of Figure 2, Examples 1 and 2 according to the present invention inhibited acetylcholine degradation depending on the concentration, in particular Example 2 was superior to Example 1 acetylcholine degradation inhibitory effect.

[Test Example 3] Event memory improvement effect through the passive avoidance test (passive avoidance test)

Mice have an instinct to like dark places. Therefore, in this experiment, the effect of improving the memory of the event was examined by checking whether the mouse enters the dark room by instinct and then enters the dark room, or if the mouse does not enter the dark room by remembering the electricity. .

In this experiment, 5 weeks-old mice of the ICR system were used, respectively, the control group (the group not administered the test substance), the low concentration of Example 1 (40 mg / 1 kg / 5 ml) administration group, and the high concentration of Example 1 (200 mg / 1). Kg / 5 ml) administration group, Example 2 low concentration (40 mg / 1 kg / 5 ml) administration group, Example 2 high concentration (200 mg / 1 kg / 5 ml) administration group, and no treatment normal group, respectively. 15 animals per group were tested. One week before the start of the experiment, 0.125 ml of distilled water was administered to the control group, and 0.125 ml of test substance was administered to each of the concentration groups in Examples 1 and 2.

<Dementia-induced Mouse Production>

It causes oxidative stress in the brain to form plaques, which cause inflammatory reactions and cause brain deterioration. Amyloid-β, which is currently considered to be the most potent substance causing Alzheimer's disease, is injected into the crown of the mouse. It caused dementia.

First, by using the passive avoidance experiment used in the memory test, the control group (5 μl injection of DW), Experimental group 1 (5 μl injection of amyloid-β 500 pmol) and Experimental group 2 (amyloid-β 1,000 pmol) 5 μl) was used to test 15 animals each, and it was confirmed that dementia was induced in Experimental Group 2, and the concentration of amyloid-β for the preparation of dementia-induced mice was determined to be 1,000 pmol. That is, the control and test substance-treated mice were treated with 5 μl of amyloid-β 1,000 pmol to produce dementia-induced mice with reduced brain function, and event memory tests were performed.

<Memory test box production>

The memory test box was made to perform the memory test. The box is composed of two rooms, each 50 cm x 50 cm x 40 cm in size, with a dark room on the left and a light room on the right with a guillotine in the middle. The door can be opened and closed to open and close according to the intention of the experimenter. The dark room is configured to allow electric current to flow as needed by connecting the power so that electricity flows for 2.0 ㎃.

<Event memory test method>

Days 1-3: Mice like dark places, so when placed in a bright place naturally enters the dark room, using this property set the first three days to adapt to the experimental equipment.

Day 4: Injecting dementia-inducing amyloid-β into each experimental group in the morning to induce dementia, and after about 5 hours, induce it to enter the dark room as before, and then close the door in the middle passage After closing the room, the mouse gave a surprisingly strong electrical stimulus, marking the dark room as a dangerous room.

Day 5: Put the mice that were tested the day before in the bright room and measure the time to move to the dark room. The more severe the dementia-induced mice, the faster the memory of the dark room was remembered.

The experimental results are shown in FIG. 3. In the results of FIG. 3, the result of the passive avoidance experiment showed a difference of 95% of the result of the Student's t-test (p = 0.0031) in the normal group and the control group that did not cause dementia, and Example 1 In the group administered with low concentration of 2 and 2 did not see a significant difference compared to the control. On the other hand, the group administered with high concentration of Example 1 was found to be effective at a significant level (p <0.05) of 95% as a result of the control and Student's t-test, and the group administered with high concentration of Example 2 was 99% significant. The effect was confirmed at the red level (p <0.01) (+: p <0.05 level of significance compared to control, *: p <0.05 level of significance compared to control, #: p compared to control) <0.01 level of significance).

[Test Example 4] Improvement of spatial perception force (Y-maze Task)

The mice that had been passively avoided were continuously administered to the mice that had been administered from one week before the passive avoidance experiment without any additional test substance until the experiment was performed.

<Y-shaped maze production>

In order to measure the spatial perceptual force, a Y-shaped labyrinth was constructed. It consists of three passages, each branch having a size of 24 cm × 14 cm × 5 cm and formed at the same angle.

<Spatial Perception Test Method>

This experiment was conducted three days after the injection of amyloid-β. When the mouse is placed in the labyrinth, it moves constantly. The mouse is placed in the Y-shaped labyrinth and started from one point. At this time, the mouse can freely move around each corner. Because of the Y-shape, the mouse reaches a dead end wall from one corner to the next, and if the perception of space remains when you turn right back to the very center, you don't go to where you just left, I want to go. That is, a mouse that has started must only make two choices when it reaches the center point, and when it comes back after making that choice, it has to make two choices again, where it has not yet been compared to the two preceding directions. In the other direction, it can be seen that there is a function of spatial perceptual force.

In this way, the mouse continuously moved during the 5-minute experiment period, and the score was measured by giving 1 point when each corner was moved in order. The score was scored by multiplying 100 by dividing the score received by moving each corner in order by the total number of moving corners, and the results are shown in FIG. 4. For example, if each corner is designated as A, B, or C, if the mouse is A → B → C → A → B → C, one point is obtained in ABC order, one point in BCA order, and then CAB. 1 point, ABC, 1 point, 4 points, 6 corners, 4 ÷ 6 × 100 = 66.67 points, and the mouse receives A → C → B → A → C → A → If B, ACB order also does not overlap, 1 point, CBA also 1 point, BAC 1 point, ACA does not have a score because A overlaps, 1 point CAB obtained a total of 4 points, so I ran a total of 7 corners 4 7 x 100 = 57.14 points.

In the results of FIG. 4, the student's Student's t-test showed a difference (p = 0.096) at a significant level (p = 0.096) of the normal group and the control group, and the Example 1 low concentration group, Example 1 high concentration group, and Example 2 low concentration group. While no significant effect was found in Example 2, the control group and Student's t-test showed a significant level of 95% (p = 0.0189) in the high-dose group (+: p <0.1 level compared to the control group). Significance, #: having a significance level of p <0.05 compared to the control).

Test Example 5 Brain Cell Activation Effect

In order to measure the proliferation and activation of brain cells, neuroblastoma, SK-N-BE (2) cell line was used. After adjusting the cell number to 1 × 10 ⁵ cell / ml, the obtained cell suspension was dispensed in 90 μl each into a 96 well plate. Add 10 μl of the test substance in proper concentration to 37 ℃, 5% CO ₂ Incubated for 72 hours in the incubator. After incubation, 10 μl of CCK-8 kit (Dojindo Laboratories, Kmamoto, Japan) solution was added to each well, followed by 37 ° C., 5% CO _2. After culturing in an incubator for 3 hours, the brain cell activity was measured by measuring 450 nm absorbance, and the results are shown in FIG. 5 (*: P <0.005) [A: group treated with 50 ppm of Example 1, B: 5 ppm of Example 1, C: 50 ppm of Example 2, D: 5 ppm of Example 2, E: 50 ppm of Examples 1 and 3, F: a group treated with 5 ppm of Examples 1 and 3, G: a group treated with 50 ppm of Examples 2 and 3, and H: a group treated with 5 ppm of Examples 2 and 3].

In the results of FIG. 5, it was confirmed that the group (C) treated with 50 ppm of the fermented product of Example 2 and the group (G) treated with Example 2 and Example 3 showed significant brain cell activity efficacy.

Claims (5)

Composition for enhancing memory, concentration, cognitive ability or learning ability, containing a complex extract consisting of Angelica, Macmundong, Baeksin, Saenghwanghwang, Baekchul, Baekshou, Ganoderma lucidum and jujube extract as active ingredients. A composition for enhancing memory, concentration, cognitive ability, or learning ability, which contains fermented products of complex extracts composed of Angelica tang, Macmun-dong, Baek-sin, Saenghwang-hwang, Baekchul, Baekshou, Ganoderma lucidum and jujube extract. 3. The method according to claim 1 or 2,
The composition is a composition for enhancing memory, concentration, cognitive ability or learning ability, characterized in that it further comprises red ginseng extract. 3. The method according to claim 1 or 2,
The composition is a composition for enhancing memory, concentration, cognitive ability or learning ability, characterized in that it further contains a fermented product of red ginseng extract. The method of claim 3, wherein
The red ginseng extract is a composition for enhancing memory, concentration, cognitive ability or learning ability, characterized in that the ultra-high pressure is produced.

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