KR20110066927A - 생체 내 영상화제로서 사용하기 위한 이사틴 유도체 - Google Patents
생체 내 영상화제로서 사용하기 위한 이사틴 유도체 Download PDFInfo
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- KR20110066927A KR20110066927A KR1020117007647A KR20117007647A KR20110066927A KR 20110066927 A KR20110066927 A KR 20110066927A KR 1020117007647 A KR1020117007647 A KR 1020117007647A KR 20117007647 A KR20117007647 A KR 20117007647A KR 20110066927 A KR20110066927 A KR 20110066927A
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- compound
- caspase
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- detection device
- isatin
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Plural Heterocyclic Compounds (AREA)
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| GB0816294.3 | 2008-09-05 | ||
| GB0816294A GB0816294D0 (en) | 2008-09-05 | 2008-09-05 | Compounds |
| GB0818076.2 | 2008-10-02 | ||
| GB0818076A GB0818076D0 (en) | 2008-10-02 | 2008-10-02 | Compounds |
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| CA2828810A1 (en) | 2011-03-01 | 2012-09-07 | Ge Healthcare Limited | Radiolabelled octreotate analogues as pet tracers |
| GB201121911D0 (en) | 2011-12-20 | 2012-02-01 | Ge Healthcare Ltd | Radiofluorination method |
| CN103183631B (zh) * | 2011-12-28 | 2016-08-24 | 天津市国际生物医药联合研究院 | 靛红-5-磺酰胺类衍生物及其在制备治疗非典型性肺炎的药物中的应用 |
| EP3456718B1 (en) * | 2016-05-10 | 2021-02-17 | Fundaçâo Oswaldo Cruz | Isatin-derived compounds, use of the compounds for the treatment of aids and hbv infections |
| CN115171929B (zh) * | 2021-04-01 | 2024-07-16 | 中核核电运行管理有限公司 | 重水堆机组给水支管与燃料通道小间隙问题处理的方法 |
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| GB1240648A (en) | 1967-08-16 | 1971-07-28 | Wyeth John & Brother Ltd | N-substituted isatins |
| AR016384A1 (es) | 1997-07-30 | 2001-07-04 | Smithkline Beecham Corp | Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta. |
| AU7625500A (en) | 1999-09-30 | 2001-04-30 | Smithkline Beecham Corporation | Caspases and apoptosis |
| PT1255752E (pt) * | 2000-02-15 | 2007-10-17 | Pharmacia & Upjohn Co Llc | Inibidores de proteína quinases: 2-indolinonas substituídas com pirrolo |
| RU2259999C2 (ru) * | 2003-08-26 | 2005-09-10 | ООО "Исследовательский институт химического разнообразия" | 1-сульфонил-1,3-дигидроиндол-2-оны, фармацевтические композиции (варианты), способ их получения и применения |
| GB0327494D0 (en) | 2003-11-26 | 2003-12-31 | Amersham Plc | Novel imaging agents |
| US7270799B2 (en) | 2004-01-15 | 2007-09-18 | Nst Neurosurvival Technologies Ltd. | Perturbed membrane-binding compounds and methods of using the same |
| US7256198B2 (en) * | 2004-02-18 | 2007-08-14 | Wyeth | Pyrimidoindolones and methods for using same |
| GB0428012D0 (en) | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
| AU2005324905B2 (en) * | 2005-01-17 | 2012-01-19 | Universitaetsklinikum Muenster | 5-pyrrolidinylsulfonyl isatin derivatives |
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| AU2009289062A1 (en) | 2010-03-11 |
| US20110195024A1 (en) | 2011-08-11 |
| EP2367816B1 (en) | 2016-11-09 |
| AU2009289062B2 (en) | 2015-01-22 |
| JP5667056B2 (ja) | 2015-02-12 |
| RU2011112075A (ru) | 2012-10-10 |
| CA2735970A1 (en) | 2010-03-11 |
| RU2535975C2 (ru) | 2014-12-20 |
| JP2012502014A (ja) | 2012-01-26 |
| MX2011002498A (es) | 2011-08-04 |
| EP2367816A1 (en) | 2011-09-28 |
| WO2010026388A1 (en) | 2010-03-11 |
| CN102171208A (zh) | 2011-08-31 |
| US8961930B2 (en) | 2015-02-24 |
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