KR20110026697A - Low irritating oral components - Google Patents

Abstract

PURPOSE: An oral composition for low irritation containing amide non-ionic surfactant and sodium lauryl sulfate is provided to ensure less irritation with respect to oral mucosa and to improve user's satisfaction. CONSTITUTION: An oral composition contains 0.001-3.0 weight% of amide non-ionic surfactant, 0.001-3.0 weight% of sodium lauryl sulfate, 0.001-3.0 weight% of taurate anionic surfactant, and 0.001-10.0 weight% of betaine ampholytic surfactant. The amide non-ionic surfactant is denoted by chemical formula C_nCONH_x(CH_2CH_2OH)_m. A toothpaste and an oral cleaner contains the oral composition.

Description

Hypoallergenic oral composition {Low irritating oral components}

The present invention relates to a hypoallergenic oral composition.

Sodium lauryl sulfate is used as a foaming agent in various types of oral compositions. Sodium lauryl sulfate, unlike other anionic surfactants, is characterized by being less bitter and rich in bubbles. However, sodium lauryl sulphate is an irritant and is known to cause stomatitis, in particular.

As such, there is a problem that anionic surfactants including sodium lauryl sulfate are generally highly irritating. Thus, some techniques are known for using amphoteric surfactants together to mitigate strong irritants and to improve cleaning and bubble properties. It is known that the complex formed between the positive charge of the amphoteric surfactant and the negative charge of the anionic surfactant confers this effect. However, most amphoteric surfactants have a problem that their amount is limited because they have a strong bitter taste.

In addition, cocamide M which is a nonionic surfactant is used for the foam stability component of a shampoo detergent. Some publications (US Patent Application Publication No. 2009-0176839) disclose the addition of cocamide ME to oral compositions, but examples of use in combination with anionic surfactants and amphoteric surfactants have been found. It is not.

It is an object of one embodiment of the present invention to provide a composition for oral cavity that is free of irritation to the oral mucosa and has excellent foaming upon use, while reducing bitterness and unpleasant taste.

The present invention provides an oral composition comprising an amide nonionic surfactant, sodium lauryl sulfate, taurate anionic surfactant, and betaine amphoteric surfactant.

The composition for oral cavity according to the present invention has little irritation to the oral mucosa, is very excellent in foam generation at the time of use, reduces bitterness and unpleasant taste, and improves the usability and satisfaction of the consumer.

Oral composition according to an embodiment of the present invention is characterized in that it contains an amide nonionic surfactant, sodium lauryl sulfate, taurate anionic surfactant, and betaine amphoteric surfactant.

In one embodiment, the amide-based nonionic surfactant may be represented by the formula C _n CONH _x (CH ₂ CH ₂ OH) _m , wherein n is an integer of 6 to 18, x is 0 or 1 , m is 1 or 2. The amide-based nonionic surfactants can be easily obtained commercially, and examples thereof include cocamide MEI Co., Ltd. (MIWON Co., Ltd.) or cocamide DI (KAO chemical).

The content of the amide nonionic surfactant may be 0.001 to 3.0% by weight, specifically 0.001 to 2.0% by weight, and more specifically 0.05 to 1.0% by weight based on the total weight of the composition. When the content of the amide nonionic surfactant is lowered, the bubble stabilizing effect is not sufficiently exhibited, and when exceeding the above range, the bitter taste may become strong and unpleasant while being mixed with sodium lauryl sulfate.

Sodium lauryl sulfate may be, for example, an anionic surfactant having an average alkyl chain length of 12 synthesized with a higher fatty acid, and is commercially available (Miwon Co., Ltd.). The content of sodium lauryl sulfate may be 0.001 to 3.0% by weight, specifically 0.01 to 3.0% by weight, more specifically 0.5 to 1.5% by weight, based on the total weight of the composition. When the content of sodium lauryl sulfate is lowered, the foaming is less likely to occur, and when the content of the sodium lauryl sulfate is exceeded, irritation to the oral mucosa may occur.

The taurate-based anionic surfactant can be prepared, for example, by dehydration of a fatty acid and N-methyltaurate mixture, and is characterized by superior foaming power and less irritation than conventional anionic surfactants. Examples of taurate-based anionic surfactants include sodium methyl cocoyl taurate (Toho chemical) and the like.

The content of the taurate-based anionic surfactant may be 0.001 to 3.0% by weight, specifically 0.001 to 2.0% by weight, more specifically 0.05 to 1.5% by weight based on the total weight of the composition. When the content of the taurate-based anionic surfactant is lowered, the foam is less likely to bubble, and when the content of the taurate-based anionic surfactant is exceeded, the combination composition of sodium lauryl sulfate may be unpleasant due to the strong bitter taste.

In addition, the composition for oral cavity of this invention contains a betaine type amphoteric surfactant as a bubble stabilizer component. As a specific compound, Cocamido propyl betaine (Similar Co., Ltd.) is mentioned. The content of the betaine amphoteric surfactant may be 0.001 to 10.0 wt%, specifically 0.01 to 3.0 wt%, more specifically 0.5 to 1.5 wt%, based on the total weight of the composition. When the content of the betaine-based amphoteric surfactant is lowered, the amount of foaming is reduced during use, and when the content exceeds the content range, the bitter taste is strong in the combination composition of sodium lauryl sulfate, which may give an unpleasant feeling.

In the composition according to an embodiment of the present invention, the total content of the surfactant may be in the range of 0.01 to 10% by weight, more specifically 0.5 to 4% by weight, based on the total weight of the composition. The content is selected to a range that is excellent in foaming and less bitter to unpleasant taste when used, without excessive irritation to the oral mucosa.

In addition, the formulation of the composition according to the present invention is not particularly limited, and may be, for example, a formulation such as toothpaste, mouthwash or mouthwash.

In one embodiment, when formulating the composition for oral cavity according to the invention as a toothpaste, if necessary, abrasives, wetting agents, foaming agents, binders, sweeteners, pH adjusting agents, preservatives, active ingredients, flavors, brighteners, pigments And solvent can be added.

Examples of the abrasive include calcium carbonate, precipitated silica, aluminum hydroxide, calcium dihydrogen phosphate, and insoluble sodium metaphosphate, and these abrasives may be added alone or in combination of two or more thereof. The amount of the abrasive added may be 1 to 60% by weight, more specifically 10 to 50% by weight, based on the total weight of the toothpaste.

As a humectant, glycerin, sorbitol liquid, polyethylene glycol, propylene glycol, etc. can be used individually or in mixture of 2 or more types. The amount of the humectant may be 10 to 60% by weight, more specifically 20 to 50% by weight based on the total weight of the toothpaste.

As the binder, carboxymethyl cellulose sodium, hydroxymethyl cellulose, carrageenan, xanthan gum, sodium alginate and the like may be used alone or in combination of two or more thereof. The content of the binder may be 0.1 to 5% by weight, more specifically 0.1 to 2% by weight based on the total weight of the toothpaste.

As a sweetening agent, saccharin sodium, aspartame, stevioside, ziitol, and licorice acid can be used individually or in mixture of 2 or more types. The sweetener content may be 0.05 to 5 wt% based on the total weight of the toothpaste.

As the pH adjusting agent, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, citric acid, sodium citrate, tartaric acid and the like can be used alone or in combination of two or more thereof.

As a preservative, paraoxybenzoic acid methyl, propyl paraoxybenzoic acid, sodium benzoate, etc. can be used individually or in mixture of 2 or more types.

The active ingredients include sodium fluoride, sodium monofluorophosphate, tin fluoride, chlorohexidine, allantoin chlorohydroxy aluminate, aminocaproic acid, tranexamic acid, triclosan, cetylpyrididium, zinc chloride, pyridoxine hydrochloride, and Tocopherol acetate etc. can be used individually or in mixture of 2 or more types.

As a fragrance | flavor, peppermint oil, spearmint oil, menthol, anetol, etc. can be used individually or in mixture of 2 or more types by appropriate quantity. Titanium oxides may be used as the brightener, food coloring as the pigment, and purified water or ethanol as the solvent.

By adding the above additives varying in composition and content in accordance with the purpose and conditions, it can be prepared by a conventional toothpaste manufacturing method.

Hereinafter, the configuration and effects of the present invention will be described in more detail with reference to formulation examples and test examples. However, these test examples and examples are provided only for the purpose of illustration in order to help the understanding of the present invention is not limited to the scope and scope of the present invention.

Example 1 and Comparative Examples 1 to 4 formulation of toothpaste

Toothpaste was prepared according to the conventional toothpaste manufacturing method according to the prescription of Table 1.

ingredient Example 1
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Comparative Example 3
(weight%) Comparative Example 4
(weight%) Spices 1.00 1.00 1.00 1.00 1.00 Methyl paraben 0.15 0.15 0.15 0.15 0.15 Carboxymethyl Cellulose Sodium 1.00 1.00 1.00 1.00 1.00 Purified water 53.73 53.88 53.88 54.63 53.93 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 Zaccarin Sodium 0.20 0.20 0.20 0.20 0.20 Sorbitol Liquid 26.00 26.00 26.00 26.00 26.00 Function 15.00 15.00 15.00 15.00 15.00 Cocamide MEI 0.15 0.00 0.15 0.15 0.00 Sodium Lauryl Sulfate 1.00 1.00 1.00 1.00 2.00 Sodium methyl cocoyl taurate 0.15 0.15 0.00 0.15 0.00 Cocamido Profile Betaine 0.90 0.90 0.90 0.00 0.00 Granules 0.50 0.50 0.50 0.50 0.50

As shown in Table 1, Example 1 includes an amide nonionic surfactant (cocamide MEI), sodium lauryl sulfate, taurate anionic surfactant (sodium methyl cocoyl taurate), and a betaine amphoteric surfactant. (Cocamido Propyl Betaine) was prepared in an appropriate combination ratio. On the contrary, Comparative Example 1 excluded the amide nonionic surfactant, Comparative Example 2 excluded the taurate anionic surfactant, and Comparative Example 3 except the betaine amphoteric surfactant was prepared toothpaste. In Comparative Example 4, a toothpaste was prepared by adding sodium lauryl sulfate in an amount of 2% by weight.

Experimental Example 1 Comparison of Foaming Power of Toothpaste

The foaming power of the toothpastes prepared in Example 1 and Comparative Examples 1 to 4 was compared. First, 5 g of each toothpaste was weighed into a beaker, and 45 g of purified water was added thereto to adjust the total content to 50 g. Then, each sample was placed in a 250 ml measuring cylinder, the inlet was blocked, and the amount of bubbles generated in the state of rotating 180 ° C. eight times under the same conditions was measured. The measurement was performed by observing a scale of 250 ml and recording the number of heights from which bubbles were generated from zero. The measurement results are shown in Table 2.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 1 time 184.25 163.75 160.75 146.5 165.75 Episode 2 186.50 164.25 160.75 146.5 167.0 3rd time 184.25 164.5 161.5 147.0 167.5 Average 185.0 164.17 161.0 146.67 166.75

Referring to Table 2, it can be seen that the toothpaste prepared in Example 1 exhibits much more foaming force than the case of other Comparative Examples 1-4. Therefore, the composition for oral cavity according to the present invention, due to the synergistic effect of each of the components, it can be seen that even when the amount of sodium lauryl sulfate, which is an irritating anionic surfactant, only half the amount of excellent foaming power.

Experimental Example 2 Evaluation of Irritability to Oral Mucosa

Twenty subjects sensitive to mucosal irritation were evaluated for irritation to the oral mucosa. Example 1 and Comparative Examples 1-4 About 1 g of the toothpaste composition of each composition was taken to a toothbrush, and when this wipe | cleaning was performed for 3 minutes, the grade of the irritation to the oral mucosa was evaluated. According to the degree of stimulation, 1 point for `` I feel strong stimulation '', 2 points for `` I feel stimulation '', 3 points for `` I almost do not feel stimulation '', and 4 points for `` I do not feel stimulation '', average score of 20 people Irritation to the oral mucosa was evaluated. The evaluation results are shown in Table 3.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Irritant to oral mucosa 3.8 3.9 3.9 3.8 2.90

Referring to Table 3, it can be seen that the toothpaste prepared in Example 1 and Comparative Examples 1 to 3, the irritation to the oral mucosa is much smaller than in Comparative Example 4. In Example 1 and Comparative Examples 1 to 3, only half of the sodium lauryl sulfate, which is an irritating anionic surfactant, was used. It is because there is little irritation to.

Experimental Example 3 Evaluation of Bitter and Other Unpleasant Tastes

For 20 panelists, about 1 g of each of the toothpaste compositions of Examples 1 and Comparative Examples 1-4 was taken in a toothbrush and after 3 minutes of wiping, bitterness and unpleasant taste were evaluated. Each was evaluated on a five-point scale (5: very strong 4: strong, 3: normal, 2: weak, 1: very weak) according to the degree of bitterness and unpleasant taste. Table 4 below shows the average values of the strengths for the bitter and unpleasant tastes evaluated.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 bitter 2.1 2.0 1.95 2.0 2.45 Unpleasant taste 2.1 2.0 2.05 2.1 2.2

Referring to Table 4, it can be seen that the toothpaste prepared according to Example 1 and Comparative Examples 1 to 3 has a lower bitterness and other unpleasant tastes, and in particular, its strength to bitterness is lower than that of Comparative Example 4.

Claims (9)

An oral composition comprising an amide nonionic surfactant, sodium lauryl sulfate, a taurate anionic surfactant, and a betaine amphoteric surfactant. The method of claim 1, The amide nonionic surfactant is represented by the formula C _n CONH _x (CH ₂ CH ₂ OH) _m , Wherein n is an integer of 6 to 18, x is 0 or 1, m is 1 or 2 composition. The method of claim 1, The content of the amide non-ionic surfactant, the composition for oral cavity, characterized in that 0.001 to 3.0% by weight based on the total weight of the composition. The method of claim 1, The content of the sodium lauryl sulfate, the composition for oral cavity, characterized in that 0.001 to 3.0% by weight based on the total weight of the composition. The method of claim 1, The content of the taurate-based anionic surfactant, the composition for oral cavity, characterized in that 0.001 to 3.0% by weight based on the total weight of the composition. The method of claim 1, The content of the betaine-based amphoteric surfactant, oral composition, characterized in that 0.001 to 10.0% by weight based on the total weight of the composition. The method of claim 1, The blending ratio of the amide nonionic surfactant, sodium lauryl sulfate, taurate anionic surfactant, and betaine amphoteric surfactant is 1-3: 1 to 20: 1 to 3: 1 based on the weight ratio. Oral composition, characterized in that 20. The method of claim 1, The total compounding amount of the surfactant in the composition is 0.01 to 10.0% by weight, based on the total weight of the composition. A toothpaste, mouthwash, or mouthwash comprising the composition for oral cavity of any one of Claims 1-8.