KR101687405B1 - Oral composition for preventing gingival disease containing natural forming agents - Google Patents

Abstract

The present invention relates to a composition for oral use containing a natural-derived foaming agent, and more particularly, to a method of producing a composition for oral cavity, which is free from irritation to the oral mucosa and which can form fine bubbles by using a suitable combination of coconut and soy- The present invention relates to an oral composition capable of effectively delivering an active ingredient to a gum.

Description

[0001] The present invention relates to a composition for preventing oral gingivitis,

The present invention relates to a composition for oral use containing a natural-derived foaming agent, and more particularly, to a method for producing an oral composition containing a natural-born foaming agent by using a coconut-derived or soybean-based foaming agent in an appropriate combination to form fine bubbles with little irritation to the oral mucosa, The present invention relates to an oral composition which can effectively transmit gum disease to an active ingredient and prevent and improve gum disease.

The use and use of sodium lauryl sulfate in oral compositions is well known and has been commercialized and widely used as a surfactant in oral compositions. In particular, unlike other anionic surfactants, bitter taste is small and bubbles are abundant, so that sodium lauryl sulfate is used as a foaming agent in most oral compositions. However, sodium lauryl sulfate is known to be a stimulant substance that causes stomatitis (Chahine L, Sempson N, Wagoner C (December 1997).) The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study Compend Contin Educ. Dent 18 (12): 1238-40.).

Accordingly, there is a need for an oral composition having excellent bubble power while reducing the content of sodium lauryl sulfate so as to reduce irritation to the oral mucosa.

Accordingly, the present inventors completed a composition for oral use having little irritation to the oral mucous membrane while making fine bubbles through the combination of naturally occurring foaming agents.

Accordingly, it is an object of the present invention to provide an oral composition having excellent foamability and excellent cleaning ability, and low stimulation to the oral mucosa.

It is another object of the present invention to provide an oral composition which is effective for the prevention of gum disease by generating fine bubbles.

In order to achieve the above object, the present invention provides an oral composition comprising a coconut-derived foaming agent and a soybean-based foaming agent.

The present invention is characterized by the fact that the use of a combination of natural-derived foaming agents provides little or no irritation to the oral mucous membranes and allows fine bubbles to be formed well, and the bubble power is excellent, so that effective ingredients can be effectively delivered to every corner of the gum when brushing, And an improvement effect.

The oral composition according to one embodiment of the present invention uses cocamidopropyl betaine, soymidopropylamine oxide and sodium lauryl sulfate.

The oral composition of the present invention comprises sodium lauryl sulfate and cocamidopropyl betaine in a ratio of 1: 0.1 to 0.99 part by weight.

In addition, the oral composition of the present invention comprises sodium lauryl sulfate and soymidopropylamine oxide in a ratio of 1: 0.1 to 0.99 part by weight.

In addition, the oral composition of the present invention comprises sodium lauryl sulfate, cocamidopropyl betaine and soymidopropyl amine oxide in a ratio of 1: 0.2 to 0.8: 0.2 to 0.8 part by weight.

The sodium lauryl sulfate used in the present invention is an anionic surfactant and is used in an amount of 0.001 to 8.0% by weight, preferably 0.1 to 2.0% by weight, based on the total weight of the composition. When the amount is less than 0.1% by weight, foaming at the time of use is not good, and when it exceeds 8.0% by weight, irritation to the oral mucosa may occur.

The cocamidopropyl betaine used in the present invention is an amphoteric surfactant as a coconut-derived surfactant. In the oral composition according to an embodiment of the present invention, 0.1 to 0.99 part by weight of cocamidopropyl betaine may be used relative to 1 part by weight of sodium lauryl sulfate. For example, cocamidopropyl Betaine may be used in an amount of 0.2 to 0.8 part by weight, and more preferably 0.25 to 0.75 part by weight of cocamidopropyl betaine may be used per 1 part by weight of sodium lauryl sulfate.

In addition, soy amidopropylamine oxide used in one embodiment of the present invention is an amphoteric surfactant as a soybean-derived surfactant. In the oral composition according to an embodiment of the present invention, soy amidopropyl amine oxide may be used in an amount of 0.1 to 0.99 part by weight based on 1 part by weight of sodium lauryl sulfate. For example, with respect to 1 part by weight of sodium lauryl sulfate, Aminopropylamine oxide may be used in an amount of 0.2 to 0.8 part by weight, and more preferably 0.2 to 0.75 parts by weight of soy amidopropyl amine oxide may be used per 1 part by weight of sodium lauryl sulfate.

The oral compositions comprising sodium lauryl sulfate, co-amidopropyl betaine and soymidopropyl amine oxide in the above-mentioned range can produce micro-bubbles well and improve cleansing to all corners of the teeth, none.

Accordingly, the composition for oral cavity according to one embodiment of the present invention can reduce the rejection of users having sensitive teeth and gums, and is also effective in preventing and improving gum disease.

The composition for oral use of the present invention is not particularly limited in its formulation and may be formulated into, for example, toothpaste, mouthwash, mouthwash, or the like.

In addition, the composition for oral use of the present invention may contain components commonly used in the art according to the formulations. For example, in the case of dentifrices, it may contain abrasives, wetting agents, binders, sweeteners, pH adjusting agents, preservatives, , Perfumes, brighteners, pigments, solvents, and the like.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples. However, the present invention is not limited thereto.

[Reference Example] Preparation of Example 1 and Comparative Examples 1 to 7

Toothpastes were prepared according to the conventional manufacturing method with the ingredients shown in Table 1 below. Specifically, Examples 1 to 3 were prepared by adding 1% of sodium lauryl sulfate surfactant, and then mixing soiiamidopropylamine oxide surfactant and cocamidopropyl betaine surfactant in various combination ratios. In Comparative Example 1, And a sodium lauryl sulfate surfactant and a soy amidopropyl amine oxide surfactant except for a propylbetaine surfactant. Comparative Example 2 was prepared by mixing a sodium lauryl sulfate surfactant and a cocamidopropyl betaine surfactant except for the isoamidopropylamine oxide surfactant. Comparative Examples 3 to 5 were prepared by mixing soymidopropylamine oxide surfactant, sodium Lauryl sulfate surfactant and cocamidopropyl betaine surfactant were respectively added to the dentifrice to prepare toothpaste.

Component (% by weight) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Spices 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Methyl paraben 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Carboxymethylcellulose sodium 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Cetylpyridinium chloride 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Sodium saccharin 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Sorbitol solution 26.00 26.00 26.00 26.00 26.00 26.00 26.00 26.00 Function silicate 15.00 15.00 15.00 15.00 15.00 15.00 15.00 15.00 Sodium lauryl sulfate 1.00 1.00 1.00 1.00 1.00 2.00 Cocamidopropyl betaine 0.75 0.25 0.50 1.00 2.00 Isoamidopropylamine oxide 0.25 0.75 0.50 1.00 2.00 Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100

[Test Example 1] Evaluation of foaming power of toothpaste

5 g of each of Examples 1 to 3 and Comparative Examples 1 to 5 were weighed in a beaker, and then 45 g of purified water was added thereto to adjust the total content to 50 g. Then, the mixture was placed in a 250-ml measuring cylinder and the inlet was closed. And the amount of bubbles generated was measured. Measurements were made from 0 to the number of bubbling heights according to a 250 ml scale. The results are shown in Table 2 below and the unit is ml.

Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 1 time 188.25 174.25 178.5 161 173 172 163.75 146.5 Episode 2 189.5 173.5 176.25 162 173.5 173.5 164.25 146.5 3rd time 189 174.25 178 159.5 174 173.5 164.5 147 Average 188.9 174 177.6 160.8 173.5 173.0 164.2 146.7

As can be seen from the above Table 2, it can be seen that the toothpaste produced by Examples 1 to 3 exhibits a larger amount of bubbles than the other Comparative Examples 1 to 5. In particular, the bubbles of the toothpaste produced by Example 1 I can confirm that it is remarkably abundant. In particular, in Comparative Examples 4 and 5 using 2% of cocamidopropyl betaine or isoamidopropylamine oxide surfactant alone, it was confirmed that the amount of bubbles was remarkably low. Comparative Example 3 using sodium lauryl sulfate alone In comparison, the amount of bubbles of Example 1 according to the present invention is much larger, so that sodium lauryl sulfate, cocamidopropyl betaine and soymidopropylamine oxide are mixed in an appropriate ratio, It can be confirmed that the power is remarkably increased.

[Test Example 2] Bubble size comparison experiment

3.5 g each of the toothpastes of Examples 1 to 3 and Comparative Examples 1 to 5 was taken and then brushed with a brushing machine (custom-made) for 30 minutes. The generated air bubbles were placed on a slide glass, covered with a cover glass, and an average cell size (cell diameter) was measured using an optical microscope (Olympus DP70, using a 4x lens).

The measured bubble size is shown in Table 3 below, and its unit is mm.

Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Average 0.05 0.3 0.2 0.35 0.4 1.1 0.4 0.35

As can be seen from Table 3 above, Examples 1 to 3, which were prepared by combining sodium lauryl sulfate, cocamidopropyl betaine and soymidopropylamine oxide surfactant in suitable proportions, It can be confirmed that the bubble size is remarkably small as compared with 1 to 5, and much more fine bubbles can be produced.

In the case of Comparative Examples 3 to 5 in which sodium lauryl sulfate, cocamidopropyl betaine or soy amidopropyl amine oxide surfactant was used in an amount of 2% by weight alone, all of the bubble sizes were remarkably large, It can be confirmed that the bubble size of Comparative Example 3 in which lauryl sulfate was used alone in an amount of 2% by weight is the largest.

[Test Example 3] Measurement of gum disease prevention effect

의 치은염 평점 기준에 따라 측정하였다. 측정결과는 하기 표 4에 나타내었다.The gingival index was measured to confirm the gum disease prevention effect, and the method was as follows. First, after screening 160 subjects, they were not allowed to take oral medications that could affect the antibiotic dosing and experimentation during the experiment. Twenty subjects were divided into each of Examples 1 to 3 and Comparative Examples 1 to 5, and the gingival index was changed by Talbott, Mandel and Chilton

Of gingivitis. The measurement results are shown in Table 4 below.

의 치은염 지수><Modified by Talbott, Mandel and Chilton

Gingivitis Index>

의 치은염평점기준

Gingivitis Rating Criteria

0: No inflammation

1: mild gingivitis (weak change of color tone and weak edema) - No bleeding in periodontal pouch

2: Middle gingivitis (redness, edema) - Hemorrhage in measuring periodontal pouch

3: High grade gingivitis (ulcer) - tendency to bleed spontaneously

Gingival index Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Initial value 0.92 ± 0.2 0.87 ± 0.1 0.90 + - 0.2 0.90 + - 0.2 0.92 ± 0.2 0.86 ± 0.1 0.87 ± 0.3 0.91 ± 0.2 4 weeks 0.51 ± 0.3 0.53 + - 0.2 0.52 + - 0.3 0.64 ± 0.3 0.65 ± 0.3 0.73 ± 0.2 0.59 ± 0.3 0.64 ± 0.3 8 weeks 0.09 ± 0.1 0.25 0.2 0.22 0.1 0.31 ± 0.1 0.40 0.2 0.69 ± 0.2 0.37 + - 0.2 0.30 ± 0.1 Improvement index 0.83 ± 0.2 0.62 ± 0.2 0.68 ± 0.2 0.59 0.2 0.52 + - 0.2 0.17 ± 0.2 0.50 ± 0.3 0.61 ± 0.2

The results of Table 4 above show that Examples 1 to 3, in particular, the toothpaste of Example 1, in which soy isamidopropylamine oxide, sodium lauryl sulfate and cocamidopropyl betaine surfactant were combined in a suitable ratio, ~ 5, the improvement of gum disease is much better.

Therefore, as can be seen from the results of Test Examples 1 to 3, when the sodium lauryl sulfate surfactant according to the present invention is used in combination with the soy amidopropyl amine oxide surfactant and the cocamidopropyl betaine surfactant in an appropriate ratio, It is possible to confirm that the bubble force is very excellent and at the same time, very fine bubbles are produced. In addition, the very fine bubbles generated are very effective in improving the gum disease by transferring cetylpyridinium chloride, which is a gum disease prevention component, to the fine areas between the teeth and between the teeth gums.

[Test Example 4] Evaluation of irritation on oral mucosa

About 40 g of the dentifrice composition of each of the above Examples 1 to 3 and Comparative Examples 1 to 5 was applied to a toothbrush using 40 subjects who were sensitive to mucous membrane stimulation and the stimulation to the oral mucosa , The score of 40 points from the average score of 40 points with the score of "I feel strong stimulus" as 1 point, "I feel stimulus" as 2 points, "I rarely feel stimulus" as 3 points, The irritation to the oral mucosa was evaluated. The results are shown in Table 5 below.

Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 On the oral mucosa
Irritation for (point) 3.95 3.75 3.8 3.55 3.1 1.65 3.65 3.6

The results of Table 5 above show that Examples 1 to 3, in particular, the toothpaste of Example 1, in which sodium lauryl sulfate, soymidopropylamine oxide and cocamidopropyl betaine surfactant were combined at an appropriate ratio, ~ 5, the irritation to the oral mucosa is much smaller. Comparative Examples 1 and 2 and Comparative Examples 4 and 5 in which soy isopropyl amide oxide and cocamidopropyl betaine surfactant were combined In addition, stimulation to the oral mucosa was less than that of Example 1, but only sodium lauryl sulfate In the case of Comparative Example 3 where 2% was used, the stimulation of the oral mucosa was the highest.

Claims (6)

An oral composition comprising cocamidopropyl betaine, soymidopropyl amine oxide, and sodium lauryl sulfate. The method according to claim 1,
Wherein the sodium lauryl sulfate and the cocamidopropyl betaine are contained in an amount of 1: 0.1 to 0.99 part by weight. The method according to claim 1,
0.1 to 0.99 parts by weight of the sodium lauryl sulfate and the soy amidopropyl amine oxide. The method according to claim 1,
Wherein said sodium lauryl sulfate, said cocamidopropyl betaine and said isoamidopropylamine oxide are contained in a ratio of 1: 0.2 to 0.8: 0.2 to 0.8 part by weight. delete 5. The method according to any one of claims 1 to 4,
Wherein the composition is for prevention and improvement of gum disease.