KR20240111568A - Oral compositions containing taurate-based surfactant - Google Patents

Abstract

This application relates to an oral composition containing a taurate-based surfactant and glutamine.

Description

Oral compositions containing taurate-based surfactant}

The present invention relates to an oral composition containing a taurate-based surfactant and glutamine.

Healthy teeth are such an important factor in determining the quality of life that they are called one of the five blessings. Accordingly, as oral health is recognized as one of the essential factors for appearance management and smooth social life, interest in oral care has recently increased, and research and development on various oral compositions are being actively conducted.

Surfactants included in oral compositions mainly create foam and lower the surface tension of foreign substances on teeth so that they can be easily removed. Sulfate-based surfactants such as sodium lauryl sulfate (SLS) have been widely used in oral compositions, but oral compositions containing sulfate-based surfactants cause severe irritation, so attempts have been made to replace them. Among them, taurate-based surfactants are amino acid-based surfactants and have the advantage of improving the high irritation that is a problem with sulfate-based surfactants, so they have emerged as a substitute for sulfate-based surfactants.

Accordingly, there is an active trend in the development and research of oral products containing taurate-based surfactants such as sodium cocoyl taurate. For example, Korean Patent Publication No. 10-2016-0112919 A discloses an oral composition effective in inhibiting tartar formation containing a taurate-based surfactant. However, in the case of taurate-based surfactants, the foaming degree is significantly lower than that of the sulfate-based surfactants, and there is a problem in that it causes unpleasant tastes such as a stuffy taste, a bitter taste, and an astringent taste, thereby reducing the user's feeling of use.

Accordingly, the present inventors identified the synergistic effect of the combination of taurate-based surfactant and glutamine on the foaming power and unpleasant taste improvement effect, and confirmed that the problems of the taurate-based surfactant can be significantly improved through the combined action with glutamine. By doing so, this application was completed.

One object of the present application is to provide an oral composition containing a taurate-based surfactant and glutamine.

This is explained in detail as follows. Meanwhile, each description and embodiment disclosed in the present application may also be applied to each other description and embodiment. That is, all combinations of the various elements disclosed in this application fall within the scope of this application. Additionally, the scope of the present application cannot be considered limited by the specific description described below. Additionally, numerous papers and patent documents are referenced and citations are indicated throughout this specification. The disclosures of the cited papers and patent documents are incorporated by reference into this specification in their entirety to more clearly explain the content of this application and the level of technical field to which this application belongs.

One aspect of the present application provides an oral composition comprising a taurate-based surfactant and glutamine.

The term "taurate-based surfactant" of the present invention refers to an amino acid-based anionic surfactant containing a taurate structure, and the taurate-based surfactant is generally well soluble in water and has a neutral to slightly alkaline state. indicates. Taurate-based surfactants are used to replace sulfate-based surfactants because they cause less irritation when used in oral compositions. However, it is known to cause unpleasant tastes such as low foaming power and a bitter, dry taste.

In one embodiment, the taurate-based surfactant is taurate, caproyl taurate, lauroyl taurate, myristoyl taurate, palmitoyl taurate, stearoyl taurate, oleoyl taurate, and cocoyl. Taurate, methyl taurate, palm oil fatty acid methyl taurate, palm kernel oil fatty acid methyl taurate, hydrogenated palm kernel oil fatty acid methyl taurate, tallow fatty acid methyl taurate, hydrogenated tallow fatty acid methyl taurate, caproyl methyl taurate, lauroyl Consisting of methyl taurate, myristoyl methyl taurate, palmitoyl methyl taurate, stearoyl methyl taurate, oleoyl methyl taurate, sodium cocoyl taurate, methyltaurine cocoyl methyl taurate and their salts. may be selected from the military.

In a preferred embodiment, the taurate-based surfactant may be sodium cocoyl taurate, and the sodium cocoyl taurate refers to a compound represented by the following formula (1). At this time, in the above formula, R refers to any alkyl group derived from coconut fatty acid, for example, it may be a C ₁ to C ₆₀ alkyl group derived from coconut, but is not limited thereto.

[Formula 1]

More specifically, the sodium cocoyl taurate may be sodium methyl cocoyl taurate. The sodium methyl cocoyl taurate is a soft, white paste surfactant derived from coconut, and is produced by reacting the amino acid taurine with coconut fatty acid.

In one embodiment, the sodium methyl cocoyl taurate may be included in an amount of 0.0001% by weight or more and 20% by weight or less, preferably 0.01% by weight or more and 10% by weight or less, and more preferably, based on the total weight of the oral composition. In other words, it may be included in an amount of 0.5% by weight or more and 5% by weight or less.

The term "glutamine" in the present invention is an alpha-amino acid having a propanamide substituent at the alpha position of the carboxylic acid, and is a compound represented by the following formula (2). This is the free amino acid that is generally most abundant in the human body, and is the main carrier of nitrogen in the human body and an important energy source for many cells.

[Formula 2]

In order to solve the problems of the conventional taurate-based surfactant, the present inventors proposed that when a taurate-based surfactant and glutamine are combined and used, the taurate-based surfactant retains the advantages of a taurate-based surfactant with low irritation while maintaining the It was confirmed that there is a synergistic effect that can improve the low foaming power, which is a limitation, and significantly improve unpleasant tastes such as the bitter and astringent taste characteristic of taurate-based surfactants, and the present invention was completed. The technical idea that the mixed use of a taurate-based surfactant and glutamine can solve the problems of conventional taurate-based surfactants and improve foaming power and feeling of use was first identified in the present invention through the continuous research process of the present inventors.

In one embodiment, the glutamine may be included in an amount of 0.005% by weight or more and less than 10% by weight relative to the total weight of the oral composition, and more specifically, may be included in an amount of 0.05% by weight or more and less than 10% by weight, and preferably 0.1% by weight or more. It may be included in less than 7% by weight, and more preferably in less than 0.3% by weight and less than 6% by weight.

Specifically, the oral composition of the present invention may include sodium cocoyl taurate and glutamine in a weight ratio of 1:0.002-10, more specifically in a weight ratio of 1:0.01-5, preferably 1:1. It can be included in a weight ratio of 0.1 - 3. Due to the mixing ratio of sodium cocoyl taurate and glutamine as described above, the oral composition of the present invention can exhibit remarkable foaming power while reducing the bitter taste before and after use. If the ratio of glutamine is higher or lower than the above range, This effect may not be implemented.

The oral composition of the present invention may have a foaming force enhancing effect. In a specific example of the present invention, it was confirmed that the foamability of the oral composition of the present invention increased significantly by nearly three times compared to the case where glutamine was not combined with the taurate-based surfactant.

The present invention may be characterized in that it does not contain sodium lauryl sulfate, and as a result, pain, irritation, and corrosion of teeth and gums due to the high irritation of sodium lauryl sulfate can be significantly improved.

In addition, the oral composition of the present invention may also exhibit a flavor improving effect. The flavor improvement effect may mean improvement in one or more selected from dry taste, bitter taste, and astringent taste. In a specific embodiment of the present invention, compared to the oral composition not containing glutamine and the oral composition using a sulfate-based surfactant, the oral composition of the present invention has a significantly improved bitter taste before and after use, providing excellent sensitivity. It was confirmed that quality was provided.

The oral composition of the present invention is not particularly limited in its formulation, and specific examples include toothpaste, oral cleaner, mouthwash, gum, candy, oral spray, oral rinse, oral ointment, oral varnish, and gum massage cream. It may have any one formulation selected from the group consisting of.

In one embodiment, when the oral composition of the present invention is in the form of a toothpaste, it may further include an abrasive, a wetting agent, a binder, a sweetener, a pH adjuster, a preservative, a medicinal ingredient, a flavor, a brightener, a colorant, a solvent, etc. Additionally, the toothpaste can be applied to existing ointment (paste) tubes as a final product formulation and packaging form.

The term “abrasive” used in the present invention refers to a substance that polishes the surface of teeth and removes plaque.

The abrasives include precipitated silica, silica gel, zirconium silicate, calcium monohydrogen phosphate, anhydrous calcium monohydrogen phosphate, hydrous alumina, light calcium carbonate, ground calcium carbonate, calcium pyrophosphate, insoluble metaphosphate, and aluminum silicate. . More specifically, the abrasive may be dental-type silica. The above abrasive components can be added alone or in combination of two or more in an amount of 5% to 60% by weight, preferably 5% to 30% by weight, based on the total weight of the composition.

The term "humectant" used in the present invention is an essential base ingredient in making an ointment-like formulation. It not only prevents the oral composition from drying and solidifying when exposed to the air and provides gloss to the surface of the toothpaste, but also, depending on the type, brushes the teeth. It refers to a substance that plays a role in providing a sweetening effect.

The humectant may include concentrated glycerin (98%), glycerin (85%), sorbitol aqueous solution (70%), amorphous sorbitol aqueous solution (70%), xylitol, polyethylene glycols, propylene glycol, etc. Components can be added individually or in combination of two or more in an amount of 40% to 70% by weight based on the total weight of the composition, but are not limited thereto.

In the present invention, the term “binder” refers to an ingredient that prevents the solid powder ingredient and the liquid ingredient from separating, and is an essential ingredient in ointment-type toothpaste.

The binder can be any type of water-soluble polymer, and may include sodium carboxymethyl cellulose derived from cellulose, carrageenans extracted from seaweed, and xanthan gum obtained from microbial metabolism. The binder component may be added singly or in combination of two or more components in an amount of 0.1% to 5% by weight, preferably 0.1% to 2% by weight, based on the total weight of the composition, but is not limited thereto.

In the present invention, the term "sweetener" refers to an ingredient used to remove unpleasant taste caused by toothpaste raw materials and improve refreshing sensation.

The sweetener includes sodium saccharin, aspartame, stevioside, xylitol, licorice acid, etc., alone or in a mixture of two or more, in an amount of 0.05% by weight or more and 5% by weight or less, preferably 0.05% by weight or more and 2% by weight or less, based on the total weight of the composition. It can be used, but is not limited to this.

The pH adjusters include sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, sodium citrate, citric acid, tartaric acid, etc., and the preservatives include methyl parabenzoic acid (methylparaben), propyl paraoxybenzoic acid, and benzoic acid. Sodium can be used alone or in a mixture of two or more types.

The term “medical ingredient” used in the present invention refers to a substance that can exhibit various medicinal effects for cleaning and cleaning teeth, and includes various functional ingredients that can be included in toothpaste, oriental medicine materials, etc.

The medicinal ingredients include fluoride, such as sodium fluoride, which forms a fluoride film on teeth and makes it resistant to acids (lactic acid, etc.), which are metabolites of caries bacteria, aminocaproic acid, allantoin and allantoin derivatives, and vitamins to prevent periodontal disease. can be used simultaneously, and for the purpose of improving oral hygiene by suppressing the proliferation of harmful microorganisms in the oral cavity, triclosan, etc., alone or in a mixture of two or more types, is used in an amount of not less than 0.01% by weight but not more than 2% by weight based on the total weight of the composition, preferably It can be added in an amount of 0.01% by weight or more and 1% by weight or less, but is not limited thereto.

Peppermint oil, spearmint oil, menthol, anethole, etc. can be mixed in an appropriate amount as the flavoring agent, titanium dioxide can be used as the brightening agent, food coloring can be used as the coloring agent, and purified water, ethanol, etc. can be used as the coloring agent. You can.

It is prepared according to a conventional toothpaste manufacturing method using the above ingredients.

In another embodiment, when the oral composition of the present invention is in the form of an oral freshener or mouthwash, the above-mentioned abrasives, wetting agents, binders, sweeteners, pH adjusters, preservatives, medicinal ingredients, fragrances, brighteners, pigments, It may further include a solvent, etc.

It is prepared using the above ingredients according to the manufacturing method of a conventional oral freshener or mouthwash.

Another aspect of the present application provides a quasi-drug composition containing a taurate-based surfactant and glutamine. The definitions of the taurate-based surfactant and glutamine are the same as those described above.

The present invention not only significantly increases the foaming power of oral compositions by combining glutamine with a taurate-based surfactant, but also significantly improves the properties that cause unpleasant tastes such as bitter, thick, and astringent tastes peculiar to taurate-based surfactants. A composition for oral use is provided. The present invention uses a taurate-based surfactant to overcome the limitations of conventional taurate-based surfactants and provides an oral composition with excellent cleansing power and flavor while retaining the characteristic of not being highly irritating.

Hereinafter, the present application will be described in more detail through examples. These examples are for illustrating the present application in more detail, and the scope of the present application is not limited by these examples.

Preparation Example 1: Preparation of toothpaste

To produce toothpaste, commonly used sodium carboxymethyl cellulose, sorbitol solution, dental-type silica, sweetener, and flavoring agents were used, and toothpaste was manufactured by combining glutamine with sodium methyl cocoyl taurate. In the case of the comparative example toothpaste, the range of glutamine content was adjusted to less than 0.005 (Comparative Example 1), or the same amount of sodium lauryl sulfate (Comparative Example 2) or sodium methyl cocoyl taurate (Comparative Example 3) was additionally prescribed.

Specifically, toothpaste was prepared by dissolving sodium fluoride and sodium saccharin in sorbitol solution and purified water, dispersing silica, and adding flavorings, etc.

The specific ingredients and contents used in the production of toothpaste are shown in Table 1 below.

Classification (unit: %) Comparative Example 1 Example 1 Example 2 Example 3 Comparative example 2 Comparative Example 3 Sorbitol solution (70%) 60 60 60 60 60 60 Dental type silica 15 15 15 15 15 15 Sodium Methyl Cocoyl Taurate 2 2 2 2 - 2 Sodium lauryl sulfate - - - - 2 - glutamine 0.001 0.05 0.5 5 - - Sodium saccharin One One One One One One Sodium Carboxymethylcellulose One One One One One One sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 Spices One One One One One One Purified water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount

Example 1: Measurement of foaminess of toothpaste

An attempt was made to measure the foaming degree of toothpaste using the toothpaste prepared in Preparation Example 1. The bubble level of toothpaste is measured by flowing saliva or purified water at a rate of 1 mL per minute using a TP foam tester, applying toothpaste to a jig made in the shape of a tooth, and then brushing the teeth 200 times for 3 minutes. The amount of bubbles was measured and shown in Table 2 as follows.

division Foam degree (mL) Comparative Example 1 30 Example 1 73 Example 2 90 Example 3 97 Comparative example 2 50 Comparative Example 3 30

As can be seen in Table 2, when the sodium methyl cocoyl taurate surfactant is combined with glutamine in an amount of 0.05% by weight or more, a composition containing glutamine in a low content of 0.001% by weight and a composition containing sodium lauryl sulfate are used as comparative examples. Compared to 1 and 2, the foaming power was about 1.5 to 2 times higher, and further, compared to the composition containing a taurate surfactant without glutamine (Comparative Example 3), the foaming power was about 2 to 3 times improved. The power was confirmed. From this, it was confirmed that the foaming degree of the sodium cocoyl taurate series oral composition of the present invention was significantly excellent.

Example 2: Sensitivity evaluation of toothpaste

Next, we sought to evaluate the emotional quality and bitter taste of toothpaste. The toothpaste prepared in Preparation Example 1 was distributed to 15 consumers, and the feeling of use, bitterness during and after brushing teeth were evaluated on a 5-point scale. Approximately 1 g of the toothpaste composition was squeezed onto a toothbrush and evaluated for bitterness during and after brushing for 3 minutes. The evaluation criteria and evaluation results are shown in Table 3 below.

division Comparative Example 1 Example 1 Example 2 Example 3 Comparative example 2 Comparative Example 3 Emotional quality satisfaction 1.5 3.8 4.4 4.3 4.1 1.5 Bitter taste when used 1.4 3.7 4.3 4.2 4 1.5 Bitter taste after use 1.5 3.7 4.1 4.2 4.2 1.5 <Evaluation criteria> 1. Satisfaction with the taste of toothpaste
1) Very dissatisfied, 2) Dissatisfied, 3) Average, 4) Satisfied, 5) Very satisfied 2. Degree of bitterness of toothpaste while brushing teeth
1) Very bitter, 2) Bitter, 3) Average, 4) Not bitter, 5) Not bitter at all. 3. Degree of bitterness of toothpaste after brushing: 1) Very bitter, 2) Bitter, 3) Average, 4) Not bitter, 5) Not bitter at all.

As can be seen in Table 3 above. In Examples 1 to 3, where 0.05% by weight or more of glutamine was combined, the feeling of use was improved by about 3 times or more compared to the composition containing a taurate-based surfactant not combined with glutamine (Comparative Example 3), and furthermore, the sulfate-based interface Even when compared to the composition containing an activator (Comparative Example 2), it exhibited a similar or better flavor. Meanwhile, in the case of Comparative Example 1, which was prescribed in combination with glutamine as low as less than 0.005% by weight, it was confirmed that the feeling of use was reduced to a similar extent as the composition included in the existing taurate-based surfactant that was not combined with glutamine.

In this way, it can be seen that when a combination of sodium cocoyl taurate surfactant and glutamine is prescribed in a specific content range, the satisfaction with the emotional quality of the oral composition containing sodium cocoyl taurate is improved, and the bitter taste during and after brushing teeth is significantly improved.

From the above results, the oral composition of the present invention, through the combination of sodium cocoyl taurate surfactant and glutamine, significantly improves irritation compared to oral compositions containing sulfate-based surfactants, while eliminating the limitations of existing taurate-based surfactants. It was confirmed that the problems of low foaming power and deterioration of emotional quality could be significantly improved, providing a synergistic effect such as excellent foaming power and feeling of use.

From the above description, a person skilled in the art to which this application belongs will be able to understand that this application can be implemented in other specific forms without changing its technical idea or essential features. In this regard, the embodiments described above should be understood in all respects as illustrative and not restrictive. The scope of the present application should be interpreted as including the meaning and scope of the patent claims described below rather than the detailed description above, and all changes or modified forms derived from the equivalent concept thereof are included in the scope of the present application.

Claims (11)

An oral composition comprising a taurate-based surfactant and glutamine.
According to paragraph 1,
The taurate-based surfactants include taurate, caproyl taurate, lauroyl taurate, myristoyl taurate, palmitoyl taurate, stearoyl taurate, oleoyl taurate, cocoyl taurate, and methyl tau. Methyl Taurate, Palm Kernel Oil Fatty Acid Methyl Taurate, Hydrogenated Palm Kernel Oil Fatty Acid Methyl Taurate, Tallow Fatty Acid Methyl Taurate, Hydrogenated Tallow Fatty Acid Methyl Taurate, Caproyl Methyl Taurate, Lauroyl Methyl Taurate, Miri One selected from the group consisting of stoyl methyl taurate, palmitoyl methyl taurate, stearoyl methyl taurate, oleoyl methyl taurate, sodium cocoyl taurate, methyltaurine cocoyl methyl taurate and salts thereof. A surfactant, oral composition.
The oral composition according to claim 1, wherein the taurate-based surfactant is sodium methyl cocoyl taurate.
The oral composition according to claim 1, wherein the glutamine is present in an amount of 0.005% by weight or more and less than 10% by weight based on the total weight of the composition.
The oral composition according to claim 1, wherein the sodium cocoyl taurate is present in an amount of 0.5% by weight or more and 5% by weight or less based on the total weight of the composition.
The composition for oral use according to claim 1, wherein the composition comprises sodium cocoyl taurate and glutamine in a weight ratio of 1:0.01-5.
The oral composition according to claim 1, wherein the composition has a foaming force enhancing effect.
The oral composition according to claim 1, wherein the composition has a bitterness improving effect.
The oral composition according to claim 1, wherein the composition does not contain sodium lauryl sulfate.
The oral composition according to claim 1, further comprising at least one selected from the group consisting of abrasives, wetting agents, binders, sweeteners, pH adjusters, preservatives, medicinal ingredients, fragrances, brighteners, pigments, and solvents.
The method of claim 1, wherein the oral composition is any one formulation selected from the group consisting of toothpaste, oral rinse, mouthwash, gum, candy, oral spray, oral rinse, oral ointment, oral varnish, and gum massage cream. A composition for oral use having a.