KR20110020874A - 분자 영상 유도된 표적 약물 처리를 통한 높은 치료 지수를 달성하는 방법 - Google Patents

분자 영상 유도된 표적 약물 처리를 통한 높은 치료 지수를 달성하는 방법 Download PDF

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Publication number
KR20110020874A
KR20110020874A KR1020107029748A KR20107029748A KR20110020874A KR 20110020874 A KR20110020874 A KR 20110020874A KR 1020107029748 A KR1020107029748 A KR 1020107029748A KR 20107029748 A KR20107029748 A KR 20107029748A KR 20110020874 A KR20110020874 A KR 20110020874A
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South Korea
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alkyl
group
peptides
compound
substituted
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Korean (ko)
Inventor
하르트무트 씨. 콜브
조셉 씨. 월쉬
카이 첸
다나라크시미 카시
피터 제이.에이치. 스코트
우메시 비. 간가달마쓰
강 첸
바니 피. 모찰라
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지멘스 메디컬 솔루션즈 유에스에이, 인크.
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Publication of KR20110020874A publication Critical patent/KR20110020874A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
KR1020107029748A 2008-05-30 2009-06-01 분자 영상 유도된 표적 약물 처리를 통한 높은 치료 지수를 달성하는 방법 Ceased KR20110020874A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5777408P 2008-05-30 2008-05-30
US61/057,774 2008-05-30

Publications (1)

Publication Number Publication Date
KR20110020874A true KR20110020874A (ko) 2011-03-03

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KR1020107029748A Ceased KR20110020874A (ko) 2008-05-30 2009-06-01 분자 영상 유도된 표적 약물 처리를 통한 높은 치료 지수를 달성하는 방법

Country Status (6)

Country Link
US (1) US8293206B2 (https=)
EP (1) EP2288388B1 (https=)
JP (1) JP5681102B2 (https=)
KR (1) KR20110020874A (https=)
CA (1) CA2726050A1 (https=)
WO (1) WO2009148554A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2395992A2 (en) 2009-02-10 2011-12-21 The Scripps Research Institute Chemically programmed vaccination
HRP20220455T1 (hr) 2012-08-31 2022-05-27 Sutro Biopharma, Inc. Modificirane aminokiseline koje sadrže azid grupu
KR20170042495A (ko) 2013-12-16 2017-04-19 제넨테크, 인크. 펩티드모방체 화합물 및 그의 항체-약물 접합체
CN108064246A (zh) 2015-06-15 2018-05-22 基因泰克公司 抗体和免疫结合物
CA2994853C (en) 2015-08-14 2023-06-27 Rc Biotechnologies, Inc. Covalent linkers in antibody-drug conjugates and methods of making and using the same

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769271A (en) * 1971-04-15 1973-10-30 Lilly Co Eli N-protected amino acids and peptides
US5188816A (en) 1984-10-18 1993-02-23 Board Of Regents, The University Of Texas System Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
EP0247156B1 (en) 1985-11-18 1993-06-23 Access Pharmaceuticals Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5219553A (en) 1986-08-04 1993-06-15 Salutar, Inc. Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI
US5087440A (en) 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
US5262532A (en) 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
US5358704A (en) 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
DE19728524A1 (de) 1997-07-04 1999-01-07 Merck Patent Gmbh Cyclische Azapeptide
US6537520B1 (en) * 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US20030125243A1 (en) * 2000-07-20 2003-07-03 Jun Liu Synthesis of cyclic peptides
US20090104119A1 (en) * 2004-08-25 2009-04-23 Majoros Istvan J Dendrimer Based Compositions And Methods Of Using The Same
AU2005294214A1 (en) * 2004-10-07 2006-04-20 Emory University Multifunctional nanoparticles conjugates and their use
EP1733742A1 (en) * 2005-06-17 2006-12-20 Universiteit Utrecht Holding B.V. Dendrimers multivalently substituted with active groups
CA2617907A1 (en) * 2005-08-05 2007-02-15 Syntarga B.V. Triazole-containing releasable linkers and conjugates comprising the same
WO2008033557A2 (en) 2006-09-15 2008-03-20 Siemens Medical Solutions Usa, Inc. Click chemistry-derived cyclic peptidomimetics as integrin markers
EP2061519B1 (en) * 2006-09-15 2016-03-30 Siemens Medical Solutions USA, Inc. Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins
US8043601B2 (en) * 2007-07-27 2011-10-25 Siemens Medical Solutions Usa, Inc. Cyclic azapeptides as integrin markers

Also Published As

Publication number Publication date
JP2011521947A (ja) 2011-07-28
EP2288388A1 (en) 2011-03-02
EP2288388B1 (en) 2016-08-31
JP5681102B2 (ja) 2015-03-04
CA2726050A1 (en) 2009-12-10
WO2009148554A1 (en) 2009-12-10
US8293206B2 (en) 2012-10-23
US20100074910A1 (en) 2010-03-25

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