KR20110020874A - 분자 영상 유도된 표적 약물 처리를 통한 높은 치료 지수를 달성하는 방법 - Google Patents

분자 영상 유도된 표적 약물 처리를 통한 높은 치료 지수를 달성하는 방법 Download PDF

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Publication number
KR20110020874A
KR20110020874A KR1020107029748A KR20107029748A KR20110020874A KR 20110020874 A KR20110020874 A KR 20110020874A KR 1020107029748 A KR1020107029748 A KR 1020107029748A KR 20107029748 A KR20107029748 A KR 20107029748A KR 20110020874 A KR20110020874 A KR 20110020874A
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South Korea
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alkyl
group
peptides
compound
substituted
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Korean (ko)
Inventor
하르트무트 씨. 콜브
조셉 씨. 월쉬
카이 첸
다나라크시미 카시
피터 제이.에이치. 스코트
우메시 비. 간가달마쓰
강 첸
바니 피. 모찰라
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지멘스 메디컬 솔루션즈 유에스에이, 인크.
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Publication of KR20110020874A publication Critical patent/KR20110020874A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
KR1020107029748A 2008-05-30 2009-06-01 분자 영상 유도된 표적 약물 처리를 통한 높은 치료 지수를 달성하는 방법 Ceased KR20110020874A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5777408P 2008-05-30 2008-05-30
US61/057,774 2008-05-30

Publications (1)

Publication Number Publication Date
KR20110020874A true KR20110020874A (ko) 2011-03-03

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KR1020107029748A Ceased KR20110020874A (ko) 2008-05-30 2009-06-01 분자 영상 유도된 표적 약물 처리를 통한 높은 치료 지수를 달성하는 방법

Country Status (6)

Country Link
US (1) US8293206B2 (enExample)
EP (1) EP2288388B1 (enExample)
JP (1) JP5681102B2 (enExample)
KR (1) KR20110020874A (enExample)
CA (1) CA2726050A1 (enExample)
WO (1) WO2009148554A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093706A2 (en) * 2009-02-10 2010-08-19 The Scripps Research Institute Chemically programmed vaccination
DK2890402T3 (da) 2012-08-31 2019-07-15 Sutro Biopharma Inc Modificerede aminosyrer omfattende en azidogruppe
UA118113C2 (uk) 2013-12-16 2018-11-26 Дженентек, Інк. Пептидоміметичні сполуки та їх кон'югати антитіла з лікарським засобом
US10017577B2 (en) 2015-06-15 2018-07-10 Genentech, Inc. Antibodies and immunoconjugates
HUE057906T2 (hu) * 2015-08-14 2022-07-28 Remegen Biosciences Inc Kovalens kötõcsoportok ellenanyag-hatóanyag konjugátumokban és eljárások elõállításukra és alkalmazásukra

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769271A (en) * 1971-04-15 1973-10-30 Lilly Co Eli N-protected amino acids and peptides
US5188816A (en) 1984-10-18 1993-02-23 Board Of Regents, The University Of Texas System Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
WO1987002893A1 (en) 1985-11-18 1987-05-21 Board Of Regents, The University Of Texas System Polychelating agents for image and spectral enhancement (and spectral shift)
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5219553A (en) 1986-08-04 1993-06-15 Salutar, Inc. Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI
US5087440A (en) 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
US5262532A (en) 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
US5358704A (en) 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
DE19728524A1 (de) 1997-07-04 1999-01-07 Merck Patent Gmbh Cyclische Azapeptide
US6537520B1 (en) * 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US20030125243A1 (en) * 2000-07-20 2003-07-03 Jun Liu Synthesis of cyclic peptides
WO2006033766A2 (en) * 2004-08-25 2006-03-30 The Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
CA2583389A1 (en) * 2004-10-07 2006-04-20 Emory University Multifunctional nanoparticles conjugates and their use
EP1733742A1 (en) 2005-06-17 2006-12-20 Universiteit Utrecht Holding B.V. Dendrimers multivalently substituted with active groups
US8158590B2 (en) * 2005-08-05 2012-04-17 Syntarga B.V. Triazole-containing releasable linkers, conjugates thereof, and methods of preparation
CA2663454C (en) 2006-09-15 2015-04-21 Siemens Medical Solutions Usa, Inc. Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins
WO2008033557A2 (en) * 2006-09-15 2008-03-20 Siemens Medical Solutions Usa, Inc. Click chemistry-derived cyclic peptidomimetics as integrin markers
EP2182974B1 (en) * 2007-07-27 2015-08-26 Siemens Medical Solutions USA, Inc. Cyclic azapeptides as integrin markers

Also Published As

Publication number Publication date
EP2288388A1 (en) 2011-03-02
WO2009148554A1 (en) 2009-12-10
CA2726050A1 (en) 2009-12-10
US8293206B2 (en) 2012-10-23
EP2288388B1 (en) 2016-08-31
JP5681102B2 (ja) 2015-03-04
JP2011521947A (ja) 2011-07-28
US20100074910A1 (en) 2010-03-25

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