KR20110014199A - 비강 비염 치료용 재조합 인간 ｃｃ10 및 이의 조성물 - Google Patents
비강 비염 치료용 재조합 인간 ｃｃ10 및 이의 조성물 Download PDFInfo
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- KR20110014199A KR20110014199A KR1020107028003A KR20107028003A KR20110014199A KR 20110014199 A KR20110014199 A KR 20110014199A KR 1020107028003 A KR1020107028003 A KR 1020107028003A KR 20107028003 A KR20107028003 A KR 20107028003A KR 20110014199 A KR20110014199 A KR 20110014199A
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| US20060281681A1 (en) | 1997-05-28 | 2006-12-14 | Pilon Aprile L | Methods and compositions for the reduction of neutrophil influx and for the treatment of bronchpulmonary dysplasia, respiratory distress syndrome, chronic lung disease, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease |
| CN102292099A (zh) | 2008-05-13 | 2011-12-21 | 科拉森斯公司 | 在鼻炎治疗中使用的重组人cc10及其组合物 |
| US9168285B2 (en) | 2009-10-15 | 2015-10-27 | Therabron Therapeutics, Inc. | Recombinant human CC10 protein for treatment of influenza and ebola |
| EP2488205B1 (en) * | 2009-10-15 | 2016-09-21 | Clarassance, Inc. | Recombinant human cc10 protein for treatment of influenza |
| WO2012170842A2 (en) | 2011-06-09 | 2012-12-13 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Peptide for protection of allergic respiratory disorders |
| CA2928035C (en) | 2012-12-27 | 2024-07-02 | Massachusetts Eye & Ear Infirmary | Treatment of rhinosinusitis with p-glycoprotein inhibitors |
| PE20200404A1 (es) * | 2013-03-15 | 2020-02-26 | Janssen Pharmaceutica Nv | Composicion farmaceutica de clorhidrato de s-ketamina |
| WO2016205430A1 (en) * | 2015-06-15 | 2016-12-22 | Therabron Therapeutics, Inc. | Recombinant human cc10 protein facilitates repair and protects against damage to the respiratory epithelium due to exposure to both cigarette and other smoke |
| JP7085485B2 (ja) | 2016-01-15 | 2022-06-16 | マサチューセッツ アイ アンド イヤー インファーマリー | 分泌型ｐ－糖タンパク質は、慢性鼻副鼻腔炎の非侵襲的バイオマーカーである |
| CN113543827B (zh) * | 2019-02-27 | 2025-01-21 | 奥蒂卡拉股份有限公司 | 用于治疗鼻、鼻腔鼻窦和鼻咽组织感染和/或炎症的方法 |
| WO2020178653A1 (en) | 2019-03-05 | 2020-09-10 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| US12295933B2 (en) | 2019-03-25 | 2025-05-13 | Massachusetts Eye And Ear Infirmary | Methods and compositions to treat and diagnose diseases or pathologies associated with inflammation of the sinuses and nasal cavity |
Family Cites Families (39)
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| US4691009A (en) | 1984-12-26 | 1987-09-01 | Repligen Corporation | Hybrid proteins produced by an ultrahigh prokaryotic expression system |
| WO1987002367A2 (en) | 1985-10-18 | 1987-04-23 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
| US4820514A (en) | 1985-12-30 | 1989-04-11 | Texas A&M University System | Low dosage of interferon to enhance vaccine efficiency |
| JP2656944B2 (ja) | 1987-04-30 | 1997-09-24 | クーパー ラボラトリーズ | タンパク質性治療剤のエアロゾール化 |
| US5266562A (en) | 1987-11-19 | 1993-11-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Anti-inflammatory agents |
| US5354269A (en) | 1991-12-20 | 1994-10-11 | Fibrogenex, Inc. | Method for treating cancer resections |
| US5491130A (en) | 1992-11-10 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide inhibitors of fibronectin and related collagen-binding proteins |
| US5482930A (en) | 1993-06-09 | 1996-01-09 | The Regents Of The University Of California | Anti-inflammatory composition and method with des-Tyr dynorphin and analogues |
| US5470885A (en) | 1993-09-29 | 1995-11-28 | The Research Foundation Of The State University Of New York | Fluorocarbons as anti-inflammatory agents |
| FR2724665B1 (fr) | 1994-09-16 | 1996-12-20 | Rhone Poulenc Rorer Sa | Procede de production de proteines recombinantes, plasmides et cellules modifiees |
| US5935860A (en) | 1995-03-07 | 1999-08-10 | The George Washington University | Use of uteroglobin expression as a molecular marker for prostatic intraepithelial neoplasia |
| US5696092A (en) | 1995-03-07 | 1997-12-09 | George Washington University | Methods and compositions for inhibiting metastasis of epithelial cell-derived cancers |
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| US5817750A (en) | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
| WO1997034997A1 (en) | 1996-03-21 | 1997-09-25 | Human Genome Sciences, Inc. | Human endometrial specific steroid-binding factor i, ii and iii |
| AU5253998A (en) | 1996-11-13 | 1998-06-03 | Board Of Regents, The University Of Texas System | Diminishing viral gene expression by promoter replacement |
| US20040047857A1 (en) | 1997-05-28 | 2004-03-11 | Pilon Aprile L. | Methods and compositions for the treatment of fibrotic conditions & impaired lung function & to enhance lymphocyte production |
| US20020160948A1 (en) * | 1998-07-21 | 2002-10-31 | Aprile Pilon | Recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions |
| US7122344B2 (en) | 1997-05-28 | 2006-10-17 | Claragen, Inc. | Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions |
| US20030207795A1 (en) | 1997-05-28 | 2003-11-06 | Pilon Aprile L. | Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions |
| US20030008816A1 (en) | 1997-05-28 | 2003-01-09 | Pilon Aprile L. | Methods and compositions for the treatment of fibrotic conditions & impaired lung function & to enhance lymphocyte production |
| US20060025348A1 (en) | 1997-05-28 | 2006-02-02 | Pilon Aprile L | Methods and compositions for the treatment of fibrotic conditions & impaired lung function & to enhance lymphocyte production |
| US6255281B1 (en) | 1997-05-28 | 2001-07-03 | Claragen, Inc. And U.S. Government | Use of recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions |
| US20060281681A1 (en) | 1997-05-28 | 2006-12-14 | Pilon Aprile L | Methods and compositions for the reduction of neutrophil influx and for the treatment of bronchpulmonary dysplasia, respiratory distress syndrome, chronic lung disease, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease |
| US20050261180A1 (en) | 1997-05-28 | 2005-11-24 | Pilon Aprile L | Use of recombinant human uteroglobin in treatment of inflammatory and fibrotic conditions |
| US20020169108A1 (en) | 1997-05-28 | 2002-11-14 | Pilon Aprile L. | Methods and compositions for the treatment of fibrotic conditions & impaired lung function & to enhance lymphocyte production |
| JP4949552B2 (ja) | 1998-04-16 | 2012-06-13 | エンサイシブ・フアーマシユーテイカルズ，インコーポレイテツド | インテグリンのそれの受容体への結合を阻害するｎ，ｎ−ジ置換アミド |
| WO2000072868A2 (en) | 1999-06-01 | 2000-12-07 | Prendergast Patrick T | Peptides for therapeutic use |
| AU1582401A (en) | 1999-11-04 | 2001-05-14 | Human Genome Sciences, Inc. | Uteroglobin-like polynucleotides, polypeptides, and antibodies |
| CA2405946A1 (en) | 2000-04-14 | 2001-10-25 | Claragen, Inc. | Methods and compositions for the treatment of fibrotic conditions and impaired lung function and to enhance lymphocyte production |
| US20020025510A1 (en) | 2000-07-26 | 2002-02-28 | Strongin Alex Y. | Screening methods based on superactivated alpha V beta 3 integrin |
| WO2003057257A1 (en) * | 2002-01-02 | 2003-07-17 | The Johns Hopkins University | Cc10 inhibits th2 cytokines and eotaxins involved in allergic diseases |
| US20090227025A1 (en) | 2003-06-06 | 2009-09-10 | The Board Of Regents Of The University Of Texas System | Ex vivo human lung/immune system model using tissue engineering for studying microbial pathogens with lung tropism |
| EP1789067B8 (en) * | 2004-08-12 | 2012-08-15 | Helsinn Healthcare S.A. | Use of growth hormone secretagogues for stimulating the motility of the gastrointestinal system |
| EP2086560A4 (en) * | 2006-11-02 | 2012-03-28 | Riolan Technologies Inc | METHODS OF TREATING EPIPHORA |
| EP1935242A1 (en) * | 2006-12-21 | 2008-06-25 | Philip Morris Products S.A. | Transgenic animal model |
| WO2009126623A2 (en) | 2008-04-08 | 2009-10-15 | Amyris Biotechnologies, Inc. | Expression of heterologous sequences |
| CN102292099A (zh) | 2008-05-13 | 2011-12-21 | 科拉森斯公司 | 在鼻炎治疗中使用的重组人cc10及其组合物 |
| EP2488205B1 (en) | 2009-10-15 | 2016-09-21 | Clarassance, Inc. | Recombinant human cc10 protein for treatment of influenza |
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| WO2009140269A2 (en) | 2009-11-19 |
| AU2009246543A1 (en) | 2009-11-19 |
| AU2009246543B2 (en) | 2015-08-06 |
| US9844580B2 (en) | 2017-12-19 |
| US20180125931A1 (en) | 2018-05-10 |
| EP2303308A4 (en) | 2012-11-07 |
| IL208940A0 (en) | 2011-01-31 |
| CN102292099A (zh) | 2011-12-21 |
| JP5773437B2 (ja) | 2015-09-02 |
| US20160158315A1 (en) | 2016-06-09 |
| JP2011520894A (ja) | 2011-07-21 |
| CA2724277A1 (en) | 2009-11-19 |
| EP2303308A2 (en) | 2011-04-06 |
| BRPI0911945A2 (pt) | 2015-10-13 |
| WO2009140269A3 (en) | 2011-10-27 |
| NZ600803A (en) | 2013-12-20 |
| MX2010012234A (es) | 2011-03-03 |
| NZ588895A (en) | 2012-07-27 |
| US20110240012A1 (en) | 2011-10-06 |
| EP3085382A1 (en) | 2016-10-26 |
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