KR20110005828A

KR20110005828A - 퀴나졸린 유도체 및 치료방법

퀴나졸린 유도체 및 치료방법 Download PDF

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Publication number: KR20110005828A
Authority: KR; South Korea
Prior art keywords: deuterium; compound; cancer; hydrogen; formula
Prior art date: 2008-03-28
Legal status : Withdrawn

Application number

KR1020107024204A

Other languages

English (en)

Korean (ko)

Inventor

크레이그 이. 마세

로저 텅

Original Assignee

콘서트 파마슈티컬즈, 인크.

Priority date

2008-03-28

Filing date

2009-03-27

Publication date

2011-01-19

2009-03-27 Application filed by 콘서트 파마슈티컬즈, 인크. filed Critical 콘서트 파마슈티컬즈, 인크.

2011-01-19 Publication of KR20110005828A publication Critical patent/KR20110005828A/ko

Status Withdrawn legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims description 70
238000011282 treatment Methods 0.000 title claims description 31
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 219
239000000203 mixture Substances 0.000 claims abstract description 76
150000003839 salts Chemical class 0.000 claims abstract description 39
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 31
201000010099 disease Diseases 0.000 claims abstract description 30
229910052805 deuterium Inorganic materials 0.000 claims description 109
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 106
-1 etolimus Chemical compound 0.000 claims description 99
239000003814 drug Substances 0.000 claims description 67
229910052739 hydrogen Inorganic materials 0.000 claims description 52
239000001257 hydrogen Substances 0.000 claims description 52
229940124597 therapeutic agent Drugs 0.000 claims description 40
206010028980 Neoplasm Diseases 0.000 claims description 28
150000002431 hydrogen Chemical class 0.000 claims description 26
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 21
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KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 7
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CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims description 5
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AXRCEOKUDYDWLF-UHFFFAOYSA-N 3-(1-methyl-3-indolyl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-3-indolyl]pyrrole-2,5-dione Chemical compound C12=CC=CC=C2N(C)C=C1C(C(NC1=O)=O)=C1C(C1=CC=CC=C11)=CN1C(CC1)CCN1CC1=CC=CC=N1 AXRCEOKUDYDWLF-UHFFFAOYSA-N 0.000 claims description 4
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