KR20100111049A - Composition for multi-functional health beverage - Google Patents
Composition for multi-functional health beverage Download PDFInfo
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- KR20100111049A KR20100111049A KR1020090029419A KR20090029419A KR20100111049A KR 20100111049 A KR20100111049 A KR 20100111049A KR 1020090029419 A KR1020090029419 A KR 1020090029419A KR 20090029419 A KR20090029419 A KR 20090029419A KR 20100111049 A KR20100111049 A KR 20100111049A
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Classifications
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- A—HUMAN NECESSITIES
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2250/00—Food ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2250/00—Food ingredients
- A23V2250/15—Inorganic Compounds
- A23V2250/156—Mineral combination
- A23V2250/16—Potassium
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/15—Inorganic Compounds
- A23V2250/156—Mineral combination
- A23V2250/161—Magnesium
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/15—Inorganic Compounds
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- A23V2250/1638—Undefined mineral extract
Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
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Abstract
Description
본 발명은 다기능성 건강 음료 조성물에 관한 것이다. 보다 구체적으로, 본 발명은 알칼리성 복합 미네랄을 함유한 다기능성 건강 음료 조성물에 관한 것이다. The present invention relates to a multifunctional health beverage composition. More specifically, the present invention relates to multifunctional health beverage compositions containing alkaline complex minerals.
인체는 영양의 3대 요소인 단백질, 전분질, 지질과 비타민 등의 기본 영양을 필요로 하지만 미네랄도 필요로 하는 것으로 알려져 있다. 반면, 근래의 음식문화는 고단백에 비타민을 첨가한 음식이 발달해 있으므로 미네랄이 결핍될 확률이 많으며, 미네랄이 결핍될 경우 여러 가지 결핍증상이 발생하게 된다. The human body needs basic nutrition such as protein, starch, lipids and vitamins, which are the three major elements of nutrition, but it is also known to require minerals. On the other hand, the recent food culture has a high protein, vitamin-added food has a high probability of deficiency of minerals, if the deficiency of minerals will cause a variety of symptoms.
특히, 필수적인 미네랄로 알려진 나트륨(Na)은 세포 외액의 중요한 성분으로서, 염소이온과 중탄산 이온과 함께 인체의 산염기 평형을 유지하고, 체액의 삼투압유지 및 체액량을 결정하는데 중요한 역할을 하며, 결핍시에는 심신이 허약하고 근육경련, 체중감소, 두통 및 불면을 유발되며, 효능으로는 정상 체액유지와 공급, 인체의 정상적인 산염기 균형유지, 정상적인 근육반응 유지 또는 정상적인 삼투압을 유지하는 효과과 있다. 또한, 마그네슘(Mg)은 인체 내에 약 20 내지 28g이 존재 하며, 약 60%가 뼈, 26%는 근육, 나머지는 연조직과 체액에 있으며, 세포내액의 중요한 구성성분으로서, 결핍시에는 신장 결석같은 신장 질환, 갑상선 기능항진증, 급성 알콜중독, 부갑상선장애, 근육경련 등이 유발되며, 효능으로는 당질대사, 지질대사, 단백질 대사와 핵산의 합성분해, 체내의 인지질(레시틴)의 합성을 돕고, 비타민 C, B 복합체, 인, 나트륨, 칼륨 및 칼슘의 대사를 보조하고 신경계통의 흥분 진정 효과가 있다. 또한, 칼륨(K)은 성인의 체내 총량이 150g정도로 세포내액의 산·알칼리 평형에 가장 중요한 미네랄이며, 결핍시에는 부정맥, 저혈당, 무력증 등이 유발되며, 효능으로는 정상 체액유지와 공급, 인체의 정상적인 산염기 균형유지, 정상적인 근육반응 유지, 정상적인 삼투압유지, 혈관 확장, 인슐린 분비 촉진, 심근경색의 방어효과가 있으며, 칼슘(Ca)은 체내 무기질 중 가장 양이 많은 원소로, 매일 700mg 정도의 칼슘이 뼈와 혈액사이를 이동하고, 결핍시에는 혈액속의 칼슘저하로 말초신경과 근육접합부의 흥분성이 높아져 가벼운 자극으로 근육, 주로 손·발·안면 근육이 수축 및 경련을 일으키는 테타니증이 유발되며, 효능으로는 골다공증, 구루병, 골절, 충치, 퇴행변성 관절증의 치료효과, 설사 예방, 알레르기 질환 또는 감기 예방, 불면증, 신경과민의 치료, 심근 수축력의 증강, 신경 및 근육의 흥분, 혈액응고작용의 촉진 효과가 있다.In particular, sodium (Na), which is known as an essential mineral, is an important component of extracellular fluid and, together with chlorine and bicarbonate ions, plays an important role in maintaining the acid-base equilibrium of the human body, and in determining the osmotic pressure of the body fluid and the amount of fluid. The body and the body are weak, causing muscle cramps, weight loss, headaches and insomnia, and the effects include maintaining and supplying normal fluids, maintaining normal acid balance of the human body, maintaining normal muscle reactions, or maintaining normal osmotic pressure. In addition, magnesium (Mg) is present in the body of about 20 to 28g, about 60% in bone, 26% in muscle, the remainder in soft tissues and body fluids, an important component of intracellular fluid, such as kidney stones when deficient Kidney disease, hyperthyroidism, acute alcoholism, parathyroid disorders, muscle spasms, and so on.Efficacy includes: carbohydrate metabolism, lipid metabolism, synthesis of protein metabolism and nucleic acid, synthesis of phospholipids (lecithin) in the body, vitamin It aids the metabolism of C, B complex, phosphorus, sodium, potassium and calcium, and has an exciting calming effect on the nervous system. In addition, potassium (K) is the most important mineral for acid-alkali equilibrium of intracellular fluid with the total body weight of adult is about 150g, and deficiency causes arrhythmia, hypoglycemia, asthenia, etc. Maintains normal acid balance, maintains normal muscle reaction, maintains normal osmotic pressure, dilates blood vessels, promotes insulin secretion, and protects against myocardial infarction. Calcium (Ca) is the most abundant element in the body's minerals. Calcium moves between bone and blood, and in deficiency, the decrease in calcium in the blood increases excitability of peripheral nerves and muscle junctions, and mild stimulation causes tetanosis, which causes muscles, mainly the hands, feet, and facial muscles to contract and cramp. , Efficacy in treating osteoporosis, rickets, fractures, tooth decay, degenerative arthrosis, prevention of diarrhea, allergy or cold, insomnia, neurosensitivity Treatment, strengthening of myocardial contractility, excitement of nerves and muscles, promoting blood coagulation.
한편, 종래의 음료는 지하에서 퍼올린 천연수, 자연수 혹은 정제수에 감미료 등 여러 가지 첨가물이 부가되어 제조되며, 이러한 음료 제품으로는 청량음료, 과실음료, 스포츠 드링크, 쥬스류 등을 들 수 있다. 또한 그 제조과정에서 첨가되는 첨가제의 종류에 따라 다양한 음료가 만들어진다. 그러나 지하수를 퍼올린 천연수, 자연수 혹은 정제수를 그대로 사용한 음료는 인체에 필요한 미네랄을 충분히 공급하기에는 부족한 단점이 있다. 따라서 최근에는 이와 같은 문제점을 해결하기 위한 기술들이 개발되고 있는데, 대한민국 등록특허 제0482999호에는 심층수 농축물을 이용한 건강음료 조성물이 개시된 바 있고, 대한민국 등록특허 제0568189호에는 해수를 음료가 개시된 바 있다. Meanwhile, conventional beverages are prepared by adding various additives such as sweeteners to natural water, natural water, or purified water sprinkled underground, and such beverage products include soft drinks, fruit drinks, sports drinks, juices, and the like. In addition, a variety of beverages are made according to the type of additives added in the manufacturing process. However, beverages using natural water, natural water, or purified water that have raised groundwater are insufficient to supply sufficient minerals for the human body. Therefore, in recent years, techniques for solving such a problem have been developed, and the Republic of Korea Patent No. 082999 discloses a health beverage composition using a deep water concentrate, and the Republic of Korea Patent No. 0568189 discloses a beverage for sea water. .
그러나 상기 종래기술에 따른 미네랄 함유 음료 및 이의 제조방법들은 바다로부터 심층수를 얻기 위해 고가의 장비 및 오랜 시간의 제조과정과 복잡한 단계들이 필요하기 때문에 시간적 및 경제적으로 효율성이 떨어지는 문제점이 있다.However, the mineral-containing beverage and its manufacturing method according to the prior art has a problem of low efficiency in terms of time and economy because expensive equipment and a long time manufacturing process and complicated steps are required to obtain deep water from the sea.
이에 본 발명자들은 체내에 미네랄을 충분히 공급할 수 있을 뿐만 아니라 활성산소의 농도를 감소시키는 효과, 혈당을 강하시키는 효과, 고지혈증을 예방할 수 있는 효과 및 아토피를 비롯한 피부질환의 치료 및 예방 효과가 우수한 다기능성 건강 음료 조성물을 개발함으로써 본 발명을 완성하였다. Therefore, the inventors of the present invention can not only supply sufficient minerals in the body, but also reduce the concentration of free radicals, lower blood sugar, prevent hyperlipidemia, and have excellent multi-functional effects of treating and preventing skin diseases including atopy. The present invention has been completed by developing a health beverage composition.
따라서 본 발명의 목적은 염화칼륨, 탄산칼륨, 염화마그네슘, 젖산칼슘, 구연산나트륨, 정백당, 정제포도당 및 물을 포함하는 다기능성 건강 음료 조성물을 제공하는 것이다. It is therefore an object of the present invention to provide a multifunctional health beverage composition comprising potassium chloride, potassium carbonate, magnesium chloride, calcium lactate, sodium citrate, white sugar, refined glucose and water.
상기와 같은 본 발명의 목적을 달성하기 위해서, 본 발명은 염화칼륨, 탄산칼륨, 염화마그네슘, 젖산칼슘, 구연산나트륨, 정백당, 정제포도당 및 물을 포함하는 다기능성 건강 음료 조성물을 제공한다. In order to achieve the object of the present invention as described above, the present invention provides a multifunctional health beverage composition comprising potassium chloride, potassium carbonate, magnesium chloride, calcium lactate, sodium citrate, white sugar, refined glucose and water.
본 발명에 따른 다기능성 건강 음료 조성물은 체내에 필요한 미네랄을 충분히 공급하는 효과가 있고, 활성산소의 농도를 감소시키는 효과가 있으며, 항산화 효과 및 혈당강화 효과가 있을 뿐만 아니라 고지혈증을 예방할 수 있는 효과가 있고 아토피 등의 피부질환을 완화 또는 개선할 수 있는 효과가 있다.Multifunctional health beverage composition according to the present invention has the effect of supplying the necessary minerals in the body sufficiently, has the effect of reducing the concentration of free radicals, antioxidant effect and blood sugar strengthening effect, as well as the effect of preventing hyperlipidemia And it is effective to alleviate or improve skin diseases such as atopy.
본 발명은 염화칼륨, 탄산칼륨, 염화마그네슘, 젖산칼슘, 구연산나트륨, 정백당, 정제포도당 및 물을 포함하는 다기능성 건강 음료 조성물을 제공한다. 보다 바람직하게는, 50~60℃로 가열한 정제수 100 중량부에 대해 염화칼륨 8~10 중량부, 탄산칼륨 40~60 중량부, 염화마그네슘 1~2 중량부, 젖산칼슘 1~2 중량부, 구연산나트륨 3~7 중량부, 정백당 15~30 중량부 및 정제포도당 2~5 중량부를 포함하는 것을 특징으로 하는 다기능성 건강 음료 조성물 조성물을 제공한다.The present invention provides a multifunctional health beverage composition comprising potassium chloride, potassium carbonate, magnesium chloride, calcium lactate, sodium citrate, white sugar, refined glucose, and water. More preferably, 8 to 10 parts by weight of potassium chloride, 40 to 60 parts by weight of potassium carbonate, 1 to 2 parts by weight of magnesium chloride, 1 to 2 parts by weight of calcium lactate, and citric acid to 100 parts by weight of purified water heated to 50 to 60 ° C. It provides a multifunctional health beverage composition composition comprising 3 to 7 parts by weight of sodium, 15 to 30 parts by weight of white sugar and 2 to 5 parts by weight of refined glucose.
본 발명의 일실시예에서는 50~60℃로 가열한 정제수 1ℓ를 기준으로 염화칼륨 80~100g, 탄산칼륨 400~600g, 염화마그네슘 10~20g, 구연산나트륨 30~70g, 젖산칼슘 10~20g, 정백당 150~300g 및 정제포도당 20~50g을 첨가하고 용해하여 이온화 시킴으로써 다기능성 건강 음료 조성물을 제조하였다.In one embodiment of the present invention, based on 1 liter of purified water heated to 50 ~ 60 ℃ potassium chloride 80 ~ 100g, potassium carbonate 400 ~ 600g, magnesium chloride 10 ~ 20g, sodium citrate 30 ~ 70g, calcium lactate 10 ~ 20g, 150 per white A multifunctional health beverage composition was prepared by adding 300 g and 20-50 g of purified glucose, dissolving and ionizing the same.
본 발명에 따른 다기능성 건강 음료 조성물의 제조에 있어서 가열한 정제수를 사용하는 이유는 차가운 정제수를 사용할 경우, 미네랄 성분들이 완전히 용해되지 않은 채 침전물로 남아있을 수 있기 때문이며, 따라서 상기 가열은 혼합된 미네랄 성분들이 침전되지 않을 정도로 정제수를 가열하는 것이 바람직하며, 더욱 바람직하게는 50℃ 내지 60℃의 온도로 가열하는 것이 바람직하다. The reason for using heated purified water in the preparation of the multifunctional health beverage composition according to the present invention is that when cold purified water is used, the mineral components may remain as precipitates without being completely dissolved, and thus the heating is performed with mixed minerals. Preferably, the purified water is heated to such an extent that no components precipitate, and more preferably, it is heated to a temperature of 50 ° C to 60 ° C.
또한, 본 발명의 조성물에 포함된 성분들에 있어서, 칼륨은 인체 내에서 그 양이 결핍되면 영양부족, 단백질 결핍, 식욕부진 등의 원인이 될 수 있으며, 반면 과잉 섭취하게 되면 만성설사, 갑상선 기능 저하 등을 유발시킬 수 있다. 따라서 본 발명에 따른 다기능성 건강 음료 조성물은 정제수 1000ml에 대하여 염화칼륨을 80~100g 포함하는 것이 바람직하며, 탄산칼륨은 400~600g 포함하는 것이 바람직하다.In addition, in the components included in the composition of the present invention, potassium may cause malnutrition, protein deficiency, anorexia, etc., if the amount is insufficient in the human body, while excessive intake of chronic diarrhea, thyroid function It may cause degradation. Therefore, the multifunctional health beverage composition according to the present invention preferably contains 80 to 100 g of potassium chloride with respect to 1000 ml of purified water, and preferably contains 400 to 600 g of potassium carbonate.
나트륨의 경우, 나트륨의 양이 결핍되면 식욕부진, 소화불량, 근육위축, 장내가스 축적 등의 원인이 될 수 있고, 반면 과도하면 피로, 신경불안증, 발작 등을 유발시킬 수 있다. 따라서 본 발명의 조성물은 정제수 1000ml에 대하여 구연산나트륨을 30~70g 포함하는 것이 바람직하다.In the case of sodium, lack of sodium may cause anorexia, indigestion, muscle atrophy, intestinal gas accumulation, etc., whereas excessive sodium may cause fatigue, anxiety and seizures. Therefore, it is preferable that the composition of this invention contains 30-70 g of sodium citrate with respect to 1000 ml of purified water.
칼슘은 물과 매우 격렬하게 반응하기 때문에 일반적으로 음료 제조에 사용이 용이하지 않다. 그러나 본 발명에서는 적절한 양의 칼슘을 첨가하여 다른 미네랄 성분들과 함께 빠른 시간에 알칼리성을 유지하는 수용액을 만들수 있게 하였다. 따라서 이와 같은 점을 고려하여, 본 발명의 조성물은 정제수 1000ml에 대하여 젖산 칼슘을 10~20g 포함하는 것이 바람직하다.Calcium reacts very vigorously with water and is generally not easy to use in beverage preparation. In the present invention, however, an appropriate amount of calcium can be added to form an aqueous solution that maintains alkalinity with other mineral components in a short time. Therefore, in view of such a point, it is preferable that the composition of this invention contains 10-20 g of calcium lactates with respect to 1000 ml of purified water.
마그네슘은 물속에서 물과 반응하여 마그네슘이 산화됨으로써 수산화이온을 형성하게 되고 형성된 수산화이온에 의해 물은 알칼리성을 띄게 되며 동시에 형성된 수소분자에 의해 환원력을 갖게 된다. 따라서 이러한 마그네슘이 본 발명의 조성물에 너무 많은 양으로 포함될 경우, 물속에서 쉽게 산화마그네슘으로 산화되어 마그네슘 표면에 산화막을 형성하기 때문에 물의 알칼리화 능력이 급속이 낮아지게 되며, 반면 너무 적은 양으로 포함될 경우 물의 알칼리화 생성 능력의 효과가 미미한 문제점이 있다. 이와 같은 점을 고려하여 본 발명의 조성물은 정제수 1000ml에 대하여 염화마그네슘을 10~20g 포함하는 것이 바람직하다.Magnesium reacts with water in water to form hydroxide ions as the magnesium is oxidized, and water is alkaline due to the hydroxide ions formed and at the same time has a reducing power by the hydrogen molecules formed. Therefore, when such magnesium is included in the composition of the present invention in an excessively large amount, the alkalizing ability of water is rapidly lowered because it is easily oxidized to magnesium oxide in water to form an oxide film on the surface of magnesium, whereas when contained in too small a quantity of water There is a problem that the effect of the alkalizing ability is insignificant. In view of such a point, the composition of the present invention preferably contains 10 to 20 g of magnesium chloride with respect to 1000 ml of purified water.
나아가, 정백당 및 포도당은 이온화된 미네랄 성분들이 재결합하는 것을 방지하여 용액을 안정화시키는 역할을 한다. 따라서 본 발명의 조성물은 정제수 1000ml에 대하여 정백당을 150~300g 포함하는 것이 바람직하고, 정제포도당은 20~50g 포함하는 것이 바람직하다.Furthermore, white sugar and glucose serve to stabilize the solution by preventing the ionized mineral components from recombining. Therefore, it is preferable that the composition of this invention contains 150-300 g of white sugar with respect to 1000 ml of purified water, and 20-50 g of refined glucose is preferable.
상기 제조된 본 발명에 따른 다기능성 건강 음료 조성물은 인체에 필요한 미네랄을 다량 함유하고 있고 높은 pH 값을 유지하여 강알칼리성을 띄는 특징이 있다. 따라서 본 발명의 다기능성 건강 음료 조성물을 이용하여 제조한 건강 음료를 소비자가 섭취할 경우, 산성화된 체액을 알칼리성으로 되돌려 혈액순환을 원활하게 하며, 활성산소를 제거할 수 있는 효과 및 항산화 효과가 있다.The multifunctional healthy beverage composition according to the present invention prepared above contains a large amount of minerals necessary for the human body and has a strong alkalinity by maintaining a high pH value. Therefore, when a consumer ingests a health beverage prepared using the multifunctional health beverage composition of the present invention, the acidified body fluid is returned to alkaline to smooth blood circulation, and has an effect of removing free radicals and an antioxidant effect. .
한편, 활성산소란 생명유지에 절대적으로 필요한 산소이지만, 안정한 분자상태인 기저삼중항산소(Ground State Triplet Oxygen)가 체내 효소계, 환원대사, 공 해물질, 광화학 반응 등의 물리적, 화학적 및 환경적 요인으로 인하여 반응성이 매우 큰 활성산소(Active Oxygen)로 전환되어 인체에 치명적인 산화독성을 야기한다. 또한, 활성산소는 세포구성 성분인 지질, 단백질, 당, DNA등에 대하여 비선택적, 비가역적 파괴 작용을 초래하여 노화현상은 물론 암을 비롯한 각종질병을 일으키는 원인으로 알려져 있다(Free Radical Theory, 1954년, Denhum Harman). 따라서 활성산소에 의해 초래되는 질병을 예방하고 치료하기 위해서는 일차적으로 체내에서 과도하게 발생하는 활성산소의 농도를 감소시키는 일, 즉 항산화 작용이 매우 중요하다. On the other hand, active oxygen is oxygen that is absolutely necessary for life support, but the stable state of the ground state triplet oxygen (Ground State Triplet Oxygen) physical, chemical and environmental factors such as enzymes, reducing metabolism, pollutants, photochemical reactions in the body Due to the conversion to very active oxygen (Active Oxygen) it causes oxidative toxicity fatal to the human body. In addition, free radicals are known to cause non-selective and irreversible destruction of cell components such as lipids, proteins, sugars, and DNA, causing aging and various diseases including cancer ( Free Radical Theory , 1954). , Denhum Harman). Therefore, in order to prevent and treat diseases caused by free radicals, it is important to first reduce the concentration of free radicals excessively generated in the body, that is, antioxidant activity.
이에 본 발명자들은 본 발명의 조성물을 함유한 다기능성 건강 음료를 섭취할 경우, 체내의 활성산소의 농도를 감소시키는 효과 및 항산화 효과가 있는지를 확인하기 위하여, 본 발명의 다기능성 건강 음료를 실험요원들에게 음용하게 한 후, 혈중 활성산소의 농도 및 항산화력을 측정하였다. 그 결과, 본 발명의 조성물을 이용하여 제조된 건강 음료를 섭취한 실험군이 시중의 건강 음료를 섭취한 대조군에 비해 혈중 활성산소의 농도가 더 많이 감소되는 것을 확인할 수 있었고, 항산화 효과 또한 더 우수한 것을 확인할 수 있었다(표 2 및 표 3 참조). 따라서 본 발명의 다기능성 건강 음료 조성물은 여러 가지 질환을 유발시킬 수 있는 혈중 활성산소의 농도를 감소시키는 효과가 우수할 뿐만 아니라 항산화 효과도 우수한 특징을 갖는다.Therefore, the inventors of the present invention, when ingesting a multifunctional health drink containing the composition of the present invention, in order to determine whether there is an effect of reducing the concentration of free radicals and antioxidant effect in the body, the experimental agent of the multifunctional health drink of the present invention After drinking them, the concentration of free radicals and antioxidant power in the blood were measured. As a result, it was confirmed that the experimental group ingesting the healthy drink prepared using the composition of the present invention had a lower concentration of free radicals in blood than the control group ingesting the healthy drink in the market, and also showed an excellent antioxidant effect. It could be confirmed (see Table 2 and Table 3). Therefore, the multifunctional health beverage composition of the present invention has not only an excellent effect of reducing the concentration of free radicals in blood that can cause various diseases, but also has an excellent antioxidant effect.
한편, 당뇨병은 혈중 포도당 농도의 상승, 인슐린 부족 또는 인슐린 작용의 감소, 포도당, 지방과 단백질 대사의 이상과 이로 인한 급성 또는 만성 합병증의 발생으로 특징지어지는 질환이며, 당뇨병 및 그의 합병증은 암, 신장순환기 질환과 더불어 세계적으로 높은 사망률을 나타내는 질환으로 현재에도 사망률이 지속적으로 증가하고 있다.Diabetes, on the other hand, is a disease characterized by elevated blood glucose levels, a lack of insulin or decreased insulin action, abnormalities in glucose, fat and protein metabolism and the resulting acute or chronic complications. In addition to circulatory diseases, mortality continues to increase worldwide.
따라서 본 발명자들은 본 발명에 따른 다기능성 건강 음료 조성물이 당뇨병 등의 질환을 예방 및 치료할 수 있는지를 확인하기 위하여, 당뇨병 환자들을 대상으로 본 발명의 다기능성 건강 음료 조성물을 함유한 건강 음료를 섭취하게 한 후 혈중의 혈당변화를 측정하였다. 그 결과, 본 발명의 건강 음료를 섭취한 환자에서 혈중의 혈당수치가 감소된 것을 확인할 수 있었다(결과 미도시).Therefore, the inventors of the present invention, in order to determine whether the multifunctional health beverage composition according to the present invention can prevent and treat diseases such as diabetes mellitus, to take a healthy beverage containing the multifunctional health beverage composition of the present invention for diabetics After that, blood glucose change was measured. As a result, it was confirmed that the blood glucose level in the blood was reduced in the patient who consumed the health drink of the present invention (result not shown).
그러므로 본 발명의 다기능성 건강 음료 조성물은 혈당을 강하시키는 작용, 혈당의 상승을 예방하는 작용 및 인슐린 분비를 증가시키는 특징이 있으므로 당뇨병 및 그의 합병증을 예방 및 치료할 수 있는 효과가 있다.Therefore, the multifunctional healthy beverage composition of the present invention has the effect of lowering blood sugar, preventing the rise of blood sugar, and increasing insulin secretion, thereby preventing and treating diabetes and its complications.
또한, 본 발명의 다기능성 건강 음료 조성물은 심혈관계 질환의 원인이 되는 고지혈증을 예방할 수 있는 효과가 있다. In addition, the multifunctional healthy beverage composition of the present invention has the effect of preventing hyperlipidemia that causes cardiovascular disease.
고지혈증은 콜레스테롤, 트리글리세라이드, 인지질 및 유리지방산 등의 혈청지질 중 하나 이상이 특이적으로 높아진 상태를 말하며, 보다 구체적으로 임상적으로 측정하였을 때, 혈중 총콜레스테롤 수치가 200㎎/dℓ이상의 높은 수치를 나타내는 경우를 고콜레스테롤 혈증, 즉 고지혈증이라고 한다. 이러한 고지혈증은 유전성 고지혈증과 이차성 고지혈증으로 나눌 수 있는데, 유전성 고지혈증은 지질 성분의 흡수, 합성 및 조절 등에 관련된 유전자의 이상에 의해 발생하고, 가족 중에 고지혈증 환자가 있으면 유전적으로 고지혈증의 발생 빈도가 높게 된다. 또한, 이차성 고지혈증은 후천적으로 과다한 동물성 지방 섭취나, 당질 섭취, 비만, 약물 등으로 인해 발생할 수 있으며, 갑상선 기능저하증, 황달, 신증후군 및 당뇨병 등의 질환에 수반된다.Hyperlipidemia refers to a condition in which one or more of the serum lipids such as cholesterol, triglycerides, phospholipids, and free fatty acids are specifically raised. More specifically, when measured clinically, blood cholesterol levels are higher than 200 mg / dℓ. It is called hypercholesterolemia, or hyperlipidemia. Such hyperlipidemia can be divided into hereditary hyperlipidemia and secondary hyperlipidemia. Hereditary hyperlipidemia is caused by abnormalities in genes related to absorption, synthesis, and regulation of lipid components, and if the family has hyperlipidemia, the incidence of genetic hyperlipidemia is high. In addition, secondary hyperlipidemia may occur due to acquired excessive animal fat intake, carbohydrate intake, obesity, drugs, etc., and is accompanied by diseases such as hypothyroidism, jaundice, nephrotic syndrome, and diabetes mellitus.
이에 본 발명자들은 본 발명의 조성물이 고지혈증을 치료 또는 예방할 수 있는 효과가 있는지 확인하기 위하여, 고지혈증 환자들에게 본 발명의 조성물을 함유한 건강 음료를 섭취하게 한 후, 혈중 콜레스테롤의 수치를 측정하였다. 그 결과, 본 발명의 조성물을 함유한 건강 음료를 섭취한 경우, 환자들의 혈중 콜레스테롤 수치가 감소한 것을 확인할 수 있었고, 나아가 3-히드록시-3-메틸글루타릴 CoA 리덕타아제에 대한 억제활성이 우수한 것을 확인할 수 있었다(결과 미도시). 따라서 상기와 같은 결과에 비추어 본 발명자들은 본 발명의 조성물이 동맥경화증, 고혈압, 뇌졸중 및 허혈성 심혈관질환의 원인이 되는 고지혈증의 치료 및 예방에 유용하게 이용될 수 있다는 것을 예상할 수 있었다.Accordingly, the present inventors, after confirming that the composition of the present invention is effective to treat or prevent hyperlipidemia, hyperlipidemic patients were ingested a healthy drink containing the composition of the present invention, and then measured the level of blood cholesterol. As a result, when the healthy drink containing the composition of the present invention, it was confirmed that the blood cholesterol level of patients was reduced, and further, the inhibitory activity against 3-hydroxy-3-methylglutaryl CoA reductase was It was confirmed that the excellent (result not shown). Therefore, in view of the above results, the present inventors could expect that the composition of the present invention could be usefully used for the treatment and prevention of hyperlipidemia that causes atherosclerosis, hypertension, stroke and ischemic cardiovascular disease.
또한 본 발명의 다기능성 건강 음료 조성물은 아토피 피부질환을 개선하는 효과가 있다. 본 발명의 일실험예에 의하면, 본 발명의 조성물을 함유한 건강 음료를 아토피 질환이 발생한 아동들에게 1주일간 섭취하게 한 후, 아토피 발병 부위를 확인한 결과, 피부 습진이 현저히 개선된 것을 확인할 수 있었다(결과 미도시).In addition, the multifunctional healthy beverage composition of the present invention has the effect of improving atopic skin disease. According to one experimental example of the present invention, after ingesting a healthy drink containing the composition of the present invention to children with atopic disease for 1 week, the site of atopic dermatitis was confirmed, and it was confirmed that skin eczema was remarkably improved. (Not shown).
따라서 복합 미네랄을 함유하고 있는 본 발명의 건강 음료 조성물은 체내의 활성산소 농도를 감소시키는 효과, 항산화 효과, 혈당강화 효과, 고지혈증 예방 효과 및 아토피 피부질환을 개선하는 효과 등 다양한 효과를 갖는 특징이 있다. Therefore, the health beverage composition of the present invention containing complex minerals has various effects such as reducing the concentration of free radicals in the body, antioxidant effect, blood sugar strengthening effect, hyperlipidemia prevention effect and atopic skin disease improvement effect, etc. .
나아가 상기 본 발명에 따른 다기능성 건강 음료 조성물에 있어서, 각 구성 성분의 첨가량은 기술된 첨가량 보다 적은 경우에는 바람직한 항산화 활성, 활성산소 감소, 혈당강화, 고지혈증 예방 및 아토피 개선 등의 효과가 나타나지 않았으며, 기술된 첨가량 보다 많은 경우에는 상기 효과들이 크게 상승하지 않았고 오히려 제조 원가가 상승하여 경제성의 효율이 감소되었다.Furthermore, in the multifunctional health beverage composition according to the present invention, when the amount of each component added is less than the described amount, the desired antioxidant activity, reduced free radicals, enhanced blood sugar, prevention of hyperlipidemia and improvement of atopy did not appear. However, in the case of more than the described addition amount, the effects did not increase significantly, but rather, the manufacturing cost increased and the economic efficiency decreased.
본 발명에 따른 조성물은 분말, 과립, 정제, 환제, 당의정제, 캡슐제, 액제, 겔제, 시럽제, 슬러리제, 현탁액 및 주사제 등으로 당업계에 공지된 방법을 이용하여 제형화 될 수 있다. Compositions according to the invention may be formulated using methods known in the art as powders, granules, tablets, pills, dragees, capsules, solutions, gels, syrups, slurries, suspensions and injections.
이하, 본 발명을 실시예에 의해 상세히 설명하기로 한다. 그러나 이들 실시예는 본 발명을 보다 구체적으로 설명하기 위한 것으로서, 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다. Hereinafter, the present invention will be described in detail by way of examples. However, these examples are intended to illustrate the present invention in more detail, and the scope of the present invention is not limited to these examples.
<실시예 1 내지 3><Examples 1 to 3>
본 발명에 따른 다기능성 건강 음료 조성물의 제조Preparation of Multifunctional Healthy Drink Composition According to the Present Invention
하기 표 1과 같은 조성비로 본 발명에 따른 다기능성 건강 음료 조성물을 제조하였다. 먼저, 정제수 1000ml을 50~60℃로 가온 유지한 후에, 염화칼륨, 탄산칼륨, 염화마그네슘, 구연산나트륨, 젖산칼슘, 정백당 및 정제포도당을 하기 조성 비율에 맞춰 차례로 넣고 서서히 교반하여 용해시킨 다음, 정치하여 안정화시킨 후 구멍 직경이 0.2㎛인 멤브레인 필터로 여과하여 불순물이 제거된 맑은 연한 미색의 액상 혼합액을 수득함으로써 본 발명의 조성물을 제조하였다. To prepare a multifunctional health beverage composition according to the present invention in the composition ratio as shown in Table 1. First, 1000 ml of purified water was kept at 50 to 60 ° C., and then potassium chloride, potassium carbonate, magnesium chloride, sodium citrate, calcium lactate, white sugar and refined glucose were added in turn according to the following composition ratio, and gradually stirred to dissolve. After stabilization, the composition of the present invention was prepared by filtering with a membrane filter having a pore diameter of 0.2 μm to obtain a clear pale off-white liquid mixture in which impurities were removed.
<제조예 1><Manufacture example 1>
본 발명의 조성물을 이용한 다기능성 건강 음료의 제조Preparation of a multifunctional healthy drink using the composition of the present invention
상기 실시예 1 내지 3에서 제조된 본 발명의 조성물 중 실시예 1의 조성물 0.08ml을 사이다와 같은 소프트 음료 시럽과 혼합하여 100ml용량의 다기능성 건강 음료를 제조하였다.In the composition of the present invention prepared in Examples 1 to 3, 0.08 ml of the composition of Example 1 was mixed with a soft beverage syrup such as cider to prepare a 100 ml multifunctional health beverage.
<제조예 2><Manufacture example 2>
본 발명의 조성물을 이용한 다기능성 건강 음료의 제조Preparation of a multifunctional healthy drink using the composition of the present invention
상기 실시예 1 내지 3에서 제조된 본 발명의 조성물 중 실시예 1의 조성물 0.1ml을 각종 과일, 야채류, 해조류, 콩, 천연 약제 등의 즙 또는 그 추출 농축액과 혼합하여 100ml용량의 다기능성 건강 음료를 제조하였다.0.1 ml of the composition of Example 1 of the composition of the present invention prepared in Examples 1 to 3 mixed with various fruits, vegetables, seaweeds, soybeans, juices such as natural medicines or extracts thereof, and 100 ml multifunctional health beverage Was prepared.
<제조예 3><Manufacture example 3>
본 발명의 조성물을 이용한 다기능성 건강 음료의 제조Preparation of a multifunctional healthy drink using the composition of the present invention
상기 실시예 1 내지 3에서 제조된 본 발명의 조성물 중 실시예 1의 조성물 0.05ml을 알콜성 음료에 첨가하여 100ml용량의 다기능성 건강 음료를 제조하였다.In the compositions of the present invention prepared in Examples 1 to 3, 0.05 ml of the composition of Example 1 was added to an alcoholic beverage to prepare a 100 ml multifunctional health beverage.
<실험예 1>Experimental Example 1
본 발명에 따른 다기능성 건강 음료의 혈중 활성산소 농도 감소효과 및 항산화력 측정Determination of free radicals concentration and antioxidant activity of multifunctional healthy beverages according to the present invention
본 발명의 다기능성 건강 음료 조성물을 이용하여 제조된 다기능성 건강 음료가 혈중의 활성산소 농도를 감소시키는 효과 및 항산화 활성이 있는지 확인하기 위하여 실험 요원 14명을 대상으로 7명은 상기 제조예 1에서 제조된 본 발명의 다기능성 건강 음료를 마시게 하였고, 나머지 7명은 대조군으로 시중의 건강 음료를 마시게 한 후 각각의 집단에 대하여 시간별로 혈중 활성산소의 농도 및 항산화력을 측정하였다. 이때 본 발명의 다기능성 건강 음료 및 대조군 음료는 실험 요원들 각각을 대상으로 단위체중당 7.0 ml(7ml/kg)이 되도록 복용하게 하였으며, 상기 실험요원들은 경기도 S대학의 신체 건강한 평균 25세의 건강한 남성을 대상으로 하였다. 상기 활성산소의 농도 측정은 실험 요원의 손가락 끝에서 검출한 말초혈액을 FORT(free oxygen radicals test, Callegari, Parma, Italy) 테스트 시약을 사용하여 측정하였는데, 즉, 20㎕의 모세관을 사용하여 채혈한 후 시약 R2에 채혈된 모세관을 넣고 큐벳을 조심스럽게 상하로 흔든 다음, 이를 다시 시약 R1에 넣고 큐벳을 1분간 원심분리하여 분리된 혈청을 가지고 측정하였다. 항산화력 측정은 FORD(free dwygen fadical defence) 테스트 시약(Callegari, Rarma, Italy)을 사용하여 측정하였는데, 즉, 큐벳에 S2 용액을 넣은 다음 50ul의 혈액을 채취하여 S1 용액과 혼합한 다음, 1분간 원심분리하여 50ul의 혈장을 채취하고 이를 S2 50ul가 들어있는 상기 큐벳에 첨가하여 측정하였다. 상기 활성산소 및 항산화력 측정은 활성산소 및 항산화력 분석기(FORMox: free oxygen radicals monitor, Callegari, Parma, Italy)를 사용하였다. 실험을 통해 측정된 결과들은 SPSS/PC 13.0버전을 통해 통계처리 하였으며 모든 자료는 평균과 표준편차로 나타내었고, 각 측정변인 간의 평균치 변화 비교는 two-way mixed ANOVA를 이용하여 분석하였으며 유의한 차이가 있을 경우 사후검증은 Bonferronu 방법을 적용하였다. 상기 측정된 혈중 활성산소 농도 및 항산화력 결과를 하기 표 2 및 표 3에 나타내었다. In order to check whether the multifunctional health beverage prepared using the multifunctional health beverage composition of the present invention has an effect of reducing the concentration of free radicals in the blood and antioxidant activity, seven of the experimental agents were manufactured in Preparation Example 1 above. The multifunctional healthy drink of the present invention was made to drink, and the remaining seven people were drinking the commercial health drink as a control group, and then measured the concentrations of free radicals and antioxidant power in the blood for each group. At this time, the multi-functional healthy drink and the control drink of the present invention were to be taken to each of the experimental agents to 7.0 ml (7ml / kg) per unit weight, the experimental personnel are healthy 25-year-old healthy body of S University of Gyeonggi-do Men were targeted. The concentration of the active oxygen was measured using a free oxygen radicals test, Callegari, Parma, Italy (FORT) test reagent, which was detected at the fingertips of the test agent, ie, blood was collected using a 20 μl capillary tube. Then, the collected capillary was added to Reagent R2, and the cuvet was carefully shaken up and down. Then, the cuvet was added to Reagent R1, and the cuvette was centrifuged for 1 minute. Antioxidant activity was measured using FORD (free dwygen fadical defence) test reagent (Callegari, Rarma, Italy), that is, put S2 solution in a cuvette, collect 50ul of blood, mix with S1 solution, and then 50 ul of plasma was collected by centrifugation and added to the cuvette containing 50 ul of S2. The active oxygen and antioxidant power was measured using an active oxygen and antioxidant analyzer (FORMox: free oxygen radicals monitor, Callegari, Parma, Italy). The results measured through the experiments were statistically processed using SPSS / PC version 13.0. All data were expressed as mean and standard deviation, and the comparison of the mean value change between each measurement variables was analyzed using two-way mixed ANOVA. If any, post-mortem examination was performed using the Bonferronu method. The measured blood oxygen free radicals and antioxidant results are shown in Tables 2 and 3 below.
복용음료Measuring time
Drink
복용음료Measuring time
Drink
그 결과, 상기 표 2 및 3에 나타낸 바와 같이, 혈중 활성산소 농도 측정 결과, 본 발명의 조성물을 이용하여 제조된 다기능성 건강 음료를 섭취한 집단이 시중에 판매되고 있는 종래 다기능성 건강 음료를 섭취한 집단 보다 혈중 활성산소의 농도가 월등히 감소되는 것을 확인할 수 있었다. 또한, 항산화력 측정 결과, 본 발명의 다기능성 건강 음료를 섭취한 집단이 시중에 판매되고 있는 다기능성 건강 음료를 섭취한 집단 보다 복용후 항산화력이 월등히 증가한 것을 확인할 수 있었다. As a result, as shown in Tables 2 and 3 above, as a result of measuring the concentration of active oxygen in the blood, the group who consumed the multifunctional healthy beverage prepared using the composition of the present invention consumed the conventional multifunctional healthy beverage sold on the market. The concentration of free radicals in blood was significantly lower than that in one group. In addition, as a result of the measurement of antioxidant power, the group ingesting the multifunctional healthy drink of the present invention was confirmed that the antioxidant power increased significantly after taking than the group ingesting the multifunctional healthy drink sold in the market.
이제까지 본 발명에 대하여 그 바람직한 실시예들을 중심으로 살펴보았다. 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자는 본 발명이 본 발명의 본질적인 특성에서 벗어나지 않는 범위에서 변형된 형태로 구현될 수 있음을 이해할 수 있을 것이다. 그러므로 개시된 실시예들은 한정적인 관점이 아니라 설명적인 관점에서 고려되어야 한다. 본 발명의 범위는 전술한 설명이 아니라 특허청구범위에 나타나 있으며, 그와 동등한 범위 내에 있는 모든 차이점은 본 발명에 포함된 것으로 해석되어야 할 것이다.So far I looked at the center of the preferred embodiment for the present invention. Those skilled in the art will appreciate that the present invention can be implemented in a modified form without departing from the essential features of the present invention. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is shown in the claims rather than the foregoing description, and all differences within the scope will be construed as being included in the present invention.
Claims (3)
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