KR20100105304A - Liquid bandage for protection of wound and skin and method for preparing the same - Google Patents

Abstract

PURPOSE: A liquid band for protecting skin and injuries and a method for manufacturing the same are provided to easily manufacture the liquid band, to obtain excellent effects for protecting the injuries and the skin from external stimulus and superior waterproof effect, and to have excellent moisture maintenance effect. CONSTITUTION: A liquid band for protecting skin and injuries includes a volatile solvent and polyurethane. The liquid band more includes one or more which are selected from an adhesive, an aromatic agent, a moisturizer, a disinfectant, a skin sedative, a local anesthetic, a keratin eliminator, or a UV blocking agent. The liquid band includes 5-400 parts by w eight of the volatile solvent, 0-5 parts by weight of the adhesive, 0-20 parts by weight of the aromatic agent, 0-20 parts by weight of the moisturizer, 0-10 parts by weight of the disinfectant, 0-10 parts by weight of the skin sedative, 0-0.1 parts by weight of the keratin eliminator, and 0-10 parts by weight of the UV blocking agent based on 100 parts by weight of the polyurethane.

Description

Liquid Bandage For Protection Of Wound and Skin And Method For Preparing The Same}

The present invention relates to a liquid band for skin and wound protection and a method for producing the same, more specifically, polyurethane and a volatile solvent, and more specifically, adhesives, fragrances, moisturizers, disinfectants, skin soothing agents, local anesthetics, exfoliants and ultraviolet rays It relates to a liquid band and a method for producing the same, characterized in that it comprises at least one member selected from the group consisting of blocking agents.

Liquid band is a product used for the healing and protection of small wounds. Unlike general bands that are tied to the skin, a liquid band is a mixture of volatile liquid and polymer material, and after the volatile liquid is volatilized, the polymer material remains to form a film. It is a mixture of chemicals with characteristics.

The liquid band protects the wound from the outside such as dust and bacteria, and protects the wound by keeping moisture inside.

As a typical liquid band, water is used as a solvent, and a polymer is a liquid band prepared in a solution state using polyvinylpyrrolidone as a polymer, ii) alcohol is used as a polymer, and cellulose nitrate is used as a polymer. Hexamethyldisiloxane or isooctane solvent is used for the liquid band and iii) solvent using nitrocellulose and methylacrylate isobutene monoisopropylmaleate. And a liquid band using no acrylate or a siloxane polymer as a main raw material.

However, when the existing liquid band is formed on the film or covered on the wound surface to protect the wound site, there is a problem that there is little elasticity due to the characteristics of the film and thus the mobility is not easy. When used in the liquid band is not good movement of the liquid band can cause local pain, as well as a lot of cases that the liquid band is easily torn and reused occurs uneconomical problems. Therefore, the development of the liquid band of the film having a high elasticity is required.

In order to solve the problems of the prior art as described above, the present invention is widely used as a biomedical polymer and is easy to the wound site requiring local mobility such as a local curved wound or joint area by using a urethane having high elasticity and toughness. In addition to being able to be used easily, it is an object to provide a liquid band excellent in skin and wound protection.

The above and other objects of the present invention can be achieved by the present invention described below.

In order to achieve the above object, the present invention comprises a polyurethane and a volatile solvent, and comprises at least one selected from the group consisting of pressure-sensitive adhesives, fragrances, moisturizers, disinfectants, skin soothing agents, local anesthetics, exfoliants and sunscreens. It provides a liquid band for wound protection, characterized in that.

In addition,

V) synthesizing polyurethane by mixing 0.8 to 1.2 moles of polyol, 0.8 to 1.2 moles of glycol, and 2.4 to 3.6 moles of aliphatic isocyanate compounds; And

Ii) 5 to 400 parts by weight of a volatile solvent, 0 to 5 parts by weight of an adhesive, 0 to 20 parts by weight of a fragrance, and 0 to 20 parts by weight of a moisturizer to the synthesized polyurethane, based on 100 parts by weight of the polyurethane. Adding 0 to 10 parts by weight of a disinfectant, 0 to 10 parts by weight of a skin sedative, 0 to 0.1 parts by weight of a local anesthetic, 0 to 15 parts by weight of an exfoliant, and 0 to 10 parts by weight of a sunscreen; It provides a method for producing a liquid band characterized in that.

As described above, according to the present invention, a liquid band for topical wound protection can be easily produced, the elasticity is very excellent, the mobility is excellent, and the effect of protecting the wound and skin from external stimuli and the waterproofing effect is excellent. In addition, when used in the event of skin troubles and dead skin cells can provide a liquid band excellent in maintaining skin soothing and moisturizing effect.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

The present invention relates to a liquid band for wound protection and a manufacturing method thereof, and more particularly, to a polyurethane and a volatile solvent, and to a pressure-sensitive adhesive, a fragrance, a moisturizer, a disinfectant, a skin soothing agent, a local anesthetic, an exfoliant and a sunscreen. A liquid band comprising at least one member selected from the group consisting of, wherein the liquid is a volatile component after applying the liquid band is volatilized and the remaining material relates to a liquid band, characterized in that to form a thin urethane film film and a manufacturing method thereof. .

The liquid band is a liquid band in a solution state including a volatile solvent, polyurethane, pressure-sensitive adhesive, fragrance, moisturizer, skin soothing agent and disinfectant, local anesthetic, exfoliant, and sunscreen.

Ethanol, benzyl alcohol, isopropyl alcohol, ethyl acetate, acetone, etc. may be used as the volatile solvent.

The polyurethane is characterized in that it can be mixed with alcohol, ethyl acetate, acetone and the like.

As the pressure-sensitive adhesive may be used polyvinylpyrrolidone, silicone, and the like, the materials may be mixed with alcohol, etc., because the adhesive has a feature that is easy to adhere to the skin can be usefully used as an additive in the band production. .

Menthol, ethyl salicylate, castor oil, tea tree oil, etc. may be used as the fragrance.

As the humectant, pinsolves (C12-C15 Alkyl Benzoate), ethanol, petrolatum, glycerin and the like can be used.

As the disinfectant or skin soothing agent, isopropyl alcohol, salicylic acid, camphor, or the like may be used.

Lidocaine, tetracaine, benzocaine and the like may be used as the local anesthetic.

As the exfoliant, alpha hydroxy acid, beta hydroxy acid, etc. may be used.

As the sunscreen agent, paraaminobenzoic acid, oxybenzone, avobenzone, cinnamate derivatives, salicylic acid derivatives, homosalates, benzophenones, zinc oxides, titanium oxides, iron oxides, magnesium oxides, and the like may be used.

The manufacturing method of the liquid band is as follows.

First, iii) synthesizing the polyurethane and ii) adding a volatile solvent to the polyurethane prepared, and selected from the group consisting of adhesives, fragrances, moisturizers, skin soothing agents, disinfectants, local anesthetics, exfoliants and sunscreens. Adding more than one species to produce a liquid band.

Synthesis of Polyurethane

In the present invention, a polyurethane is synthesized by mixing 0.8 to 1.2 moles of polyol, 0.8 to 1.2 moles of glycol, and 2.4 to 3.6 moles of aliphatic isocyanate compounds.

First, 0.8 to 1.2 moles, preferably 1 mole, and 0.8 to 1.2 moles, preferably 1 mole of polyol are added using a prepolymer synthesis method and the temperature is raised to 60 ° C. to 70 ° C. with gentle stirring. .

Examples of the polyol include polyethylene oxide polyol, polypropylene oxide polyol, polyethylene propylene oxide copolymer polyol, polytetramethylene glycol Etc. can be used.

Ethylene glycol, propylene glycol, 1, 4-butanediol, 1, 5-pentanediol, 1, 6-hexanediol, diethylene glycol, triethylene glycol, polyethylene glycol, polytetramethylene glycol, etc. may be used as the glycol. .

The polyol and glycol are added in a weight ratio of 1.2: 1 to 1: 1.2, preferably in a weight ratio of 1: 1, in order to impart elasticity to the urethane film. And, maintaining the stirring temperature at 60 ℃ to 70 ℃ to maintain the activation of the reaction.

2.4 to 3.6 moles, preferably 3 moles of aliphatic isocyanate compounds are added to the solution and maintained at 110 ± 2 ° C. while gradually increasing the temperature.

For example, when 3 moles of isocyanate is added and reacted, a prepolymer having 1 mole of terminal NCO groups can be produced.

The aliphatic diisocyanate compounds are used to form a skeletal structure of urethane, specifically, isophorone diisocyanate, 1,6-hexamethylene diisocyanate, 1,5-naphthalenedi Isocyanates, 4,4-dicyclohexyl methane diisocyanate, 2,2,4-trimethylhexamethylene diisocyanate, 2,4,4-trimethylhexamethylene diisocyanate, etc. can be used.

In addition, since the reaction does not proceed or the side reaction proceeds at a temperature outside the 110 ± 2 ℃ range, the desired urethane structure cannot be obtained.

After 3 hours in which the mixture of isocyanate and polyol is maintained at the temperature (110 ± 2 ° C.), NCO% present in the group of isocyanate is measured. Lower the reaction to stop.

Then, ethylacetate and ethanol are added and diluted for smooth reaction between the prepolymer having a terminal NCO group and the di-amines (DI-AMINEs) compound. In order to increase the physical properties and the viscosity of the synthesized urethane, a dilution of di-amines (DI-AMINEs) compound: alcohol = 1: 1 weight ratio is prepared in the prepared prepolymer in the state of drop preparation (DROP CHARGE). . At this time, when a di-amine (DI-AMINE) compound, which is a catalyst capable of accelerating the reaction rate of the isocyanate and the polyol, is introduced, it is polymerized by reacting with the isocyanate at the end of the prepolymer.

The di-amines (DI-AMINEs) compounds are reaction catalysts, and specifically, m-phenylenediamine, diethyltoluenediamine, dimethylthiotoluenediamine and the like can be used.

Ethanol, isopropyl alcohol, etc. may be used as the alcohol.

<Step of manufacturing liquid band>

A volatile solvent is added to the polyurethane prepared above, and a liquid band is prepared by adding one or more selected from the group consisting of an adhesive, a perfume, a moisturizer, a disinfectant, a skin soothing agent, a local anesthetic, an exfoliant, and a sunscreen.

Injecting a volatile organic solvent to the prepared polyurethane, the content of the volatile organic solvent is based on 100 parts by weight of the polyurethane 5-400 weight part is preferable. If the content is less than 5 parts by weight, the film thickness of the urethane is thick and film drying is slow, there is a restriction on use, and if the content exceeds 400 parts by weight, the film thickness is thinned to reduce the wound protection function.

Ethanol, benzyl alcohol, isopropyl alcohol, ethyl acetate, acetone and the like can be used as the volatile solvent.

In order to impart adhesion to the solution, an adhesive such as polyvinylpyrrolidone, silicone, or the like is added, which is used to improve adhesion to skin when forming a urethane film, and is 0 to 100 parts by weight of the polyurethane. 10 parts by weight is used, preferably 1 to 3 parts by weight, most preferably 1 part by weight.

In order to impart aroma to the liquid polyurethane, 0 to 20 parts by weight based on 100 parts by weight of the polyurethane is used as a fragrance, and preferably 1 to 10 parts by weight. If it exceeds 20 parts by weight, the physical properties of the urethane may be affected and elasticity may be lost when the urethane is filmed. Menthol, ethyl salicylate, castor oil, tea tree oil, etc. may be used as the fragrance.

In order to impart a moisturizing effect to the liquid polyurethane, 0 to 20 parts by weight based on 100 parts by weight of the polyurethane is used, and preferably 5 to 15 parts by weight. If it exceeds 20 parts by weight, the physical properties of the urethane may be affected and elasticity may be lost when the polyurethane is filmed. As the humectant, pinsolves (C12-C15 Alkyl Benzoate), ethanol, petrolatum, glycerin and the like can be used.

Disinfectants (skin soothing effects) or skin soothing agents that can be mixed with the organic solvent are added to protect and repair the wound. Isopropyl alcohol, salicylic acid, camphor, etc. may be used as the disinfectant or skin sedative, and 0 to 10 parts by weight, preferably 2 to 5 parts by weight, based on 100 parts by weight of the polyurethane. When it exceeds 10 parts by weight, the volatilization rate is slowed and filming proceeds slowly.

A local anesthetic is used to impart a pain relieving effect to the liquid polyurethane, and the content is 0 to 0.1 parts by weight, preferably 0.01 to 0.05 parts by weight based on 100 parts by weight of the polyurethane. If it exceeds 0.1 parts by weight, the anesthesia time of the site may be long, which may cause trouble in life. Lidocaine, tetracaine, benzocaine and the like may be used as the local anesthetic.

In order to give an exfoliating effect to the liquid polyurethane, an exfoliating agent is used, the content of which is 0 to 20 parts by weight, preferably 5 to 15 parts by weight, based on 100 parts by weight of the polyurethane. If it exceeds 20 parts by weight, the physical properties of the urethane may be affected and elasticity may be lost when the polyurethane is filmed. As the exfoliant, alpha hydroxy acid, beta hydroxy acid, etc. may be used.

A sunscreen is used to impart a sunscreen effect to the liquid polyurethane, the content of which is 0 to 10 parts by weight, preferably 2 to 5 parts by weight, based on 100 parts by weight of the polyurethane. If it exceeds 10 parts by weight, the properties of the urethane may be affected, and the elasticity may be lost when the polyurethane is filmed. As the sunscreen agent, paraaminobenzoic acid, oxybenzone, avobenzone, cinnamate derivatives, salicylic acid derivatives, homosalates, benzophenones, zinc oxides, titanium oxides, iron oxides, magnesium oxides, and the like may be used.

The present invention will be described in more detail with reference to the following examples. However, these embodiments are merely exemplary and do not limit the technical scope of the present invention.

[Example]

<Liquid Urethane Synthesis>

Example  One

First, 1 mol of polytetramethylene glycol and 1 mol of ethylene glycol are added using a prepolymer synthesis method, and then the temperature is raised to 65 ° C. while gradually stirring. 3 moles of isophorone diisocyanate is added to the solution as an aliphatic isocyanate compound which will form a skeletal structure of urethane, and is maintained at 110 ° C while gradually increasing the temperature. 3 hours after the mixture of the isocyanate and the polyol is maintained at the above temperature, NCO% present in the group of isocyanate is measured. When the temperature falls below 4.1% of the theoretical NCO%, the reaction is stopped by lowering the temperature using cooling water.

Herein, ethyl acetate and isopropyl alcohol are added and diluted to facilitate the reaction between the prepolymer having a terminal NCO group and 1 mol of m-phenylenediamine. When pre-prepared dilution of m-phenylenediamine: isopropyl alcohol = 1: 1 weight ratio to the synthesized prepolymer (DROP CHARGE), m-phenylenediamine reacts with isocyanate at the end of the prepolymer. Polymerized, colorless, transparent and viscous Liquid urethanes are synthesized.

Example  2

First, 1 mole of polyethylene oxide polyol and 1 mole of ethylene glycol are added using a prepolymer synthesis method, and then the temperature is raised to 65 ° C. while gradually stirring. 3 moles of isophorone diisocyanate is added to the solution as an aliphatic isocyanate compound which will form a skeletal structure of urethane, and is maintained at 110 ° C while gradually increasing the temperature. 3 hours after the mixture of the isocyanate and the polyol is maintained at the above temperature, NCO% present in the group of isocyanate is measured. When the temperature falls below 4.1% of the theoretical NCO%, the reaction is stopped by lowering the temperature using cooling water.

Herein, ethyl acetate and isopropyl alcohol are added and diluted to facilitate the reaction between the prepolymer having a terminal NCO group and 1 mol of m-phenylenediamine. When pre-prepared dilution of m-phenylenediamine: isopropyl alcohol = 1: 1 weight ratio to the synthesized prepolymer (DROP CHARGE), m-phenylenediamine and isocyanate at the end of the prepolymer are polymerized by reaction. Colorless transparent and viscous Liquid urethanes are synthesized.

Example  3

First, 1 mol of polytetramethylene glycol and 1 mol of ethylene glycol are added by using a prepolymer synthesis method, and then the temperature is raised to 65 ° C. while gradually stirring. 3 moles of isophorone diisocyanate as aliphatic isocyanate compounds which will form a skeleton structure of urethane in the solution and 0.3 mole of silicon is added to increase the adhesive force when forming the final film, and the temperature is gradually increased and maintained at 110 ° C. . 3 hours after the mixture of the isocyanate and the polyol is maintained at the above temperature, NCO% present in the group of isocyanate is measured. When the temperature falls below 4.1% of the theoretical NCO%, the reaction is stopped by lowering the temperature using cooling water.

Herein, ethyl acetate and isopropyl alcohol are added and diluted to facilitate the reaction between the prepolymer having a terminal NCO group and 1 mol of m-phenylenediamine. When pre-prepared dilution of m-phenylenediamine: isopropyl alcohol = 1: 1 weight ratio to the synthesized prepolymer (DROP CHARGE), m-phenylenediamine and isocyanate at the end of the prepolymer are polymerized by reaction. Colorless transparent and viscous Liquid urethanes are synthesized.

Example  4

First, 1 mol of polytetramethylene glycol and 1 mol of ethylene glycol are added by using a prepolymer synthesis method, and then the temperature is raised to 65 ° C. while gradually stirring. 3 moles of isophorone diisocyanate is added to the solution as an aliphatic isocyanate compound which will form a skeletal structure of urethane, and is maintained at 110 ° C while gradually increasing the temperature. 3 hours after the mixture of the isocyanate and the polyol is maintained at the above temperature, NCO% present in the group of isocyanate is measured. When the temperature falls below 4.1% of the theoretical NCO%, the reaction is stopped by lowering the temperature using cooling water.

Herein, ethyl acetate and ethanol are added and diluted for smooth reaction between the prepolymer having a terminal NCO group and 1 mol of m-phenylenediamine. When a pre-prepared dilution of m-phenylenediamine: ethanol = 1: 1 weight ratio is prepared to the synthesized prepolymer, DROP CHARGE, m-phenylenediamine and isocyanate at the end of the prepolymer are polymerized by reaction. Transparent and viscous Liquid urethanes are synthesized.

Example  5

First, 0.5 mol of polytetramethylene glycol, 1 mol of ethylene glycol and 1,4 butylene glycol are added to each other using a prepolymer synthesis method, and then the temperature is raised to 65 ° C. while gradually stirring. 3 moles of isophorone diisocyanate is added to the solution as an aliphatic isocyanate compound which will form a skeletal structure of urethane, and is maintained at 110 ° C while gradually increasing the temperature. 3 hours after the mixture of the isocyanate and the polyol is maintained at the above temperature, NCO% present in the group of isocyanate is measured. When the temperature falls below 4.1% of the theoretical NCO%, the reaction is stopped by lowering the temperature using cooling water.

Herein, ethylacetate and ethanol are added and diluted for smooth reaction between the prepolymer having a terminal NCO group and 1 mol of m-phenylenediamine. When a pre-prepared dilution of m-phenylenediamine: ethanol = 1: 4 weight ratio is prepared in the prepared prepolymer, the drop charge (DROP CHARGE) causes m-phenylenediamine and isocyanate at the end of the prepolymer to polymerize to be colorless. Transparent and viscous Liquid urethanes are synthesized.

Example  6

First, 0.5 mol of polytetramethylene glycol, 1 mol of ethylene glycol, and 1,4 butylene glycol are added to each other using a prepolymer synthesis method, and then the temperature is raised to 65 ° C. while gradually stirring. 3 moles of isophorone diisocyanate is added to the solution as an aliphatic isocyanate compound which will form a skeletal structure of urethane, and is maintained at 110 ° C while gradually increasing the temperature. 3 hours after the mixture of the isocyanate and the polyol is maintained at the above temperature, NCO% present in the group of isocyanate is measured. When the temperature falls below 4.1% of the theoretical NCO%, the reaction is stopped by lowering the temperature using cooling water.

Herein, dilution of the pinsolve (C12-C15 Alkyl Benzoate) and ethanol is carried out for smooth reaction between the prepolymer having a terminal NCO group and 1 mol of m-phenylenediamine and for moisturizing during the final film formation. When a pre-prepared dilution of m-phenylenediamine: ethanol = 1: 4 weight ratio is prepared in the prepared prepolymer, the drop charge (DROP CHARGE) causes m-phenylenediamine and isocyanate at the end of the prepolymer to polymerize to be colorless. Transparent and viscous Liquid urethanes are synthesized.

Example  7

First, 0.5 mol of polytetramethylene glycol, 1 mol of ethylene glycol and 1,4 butylene glycol are added to each other using a prepolymer synthesis method, and then the temperature is raised to 65 ° C. while gradually stirring. 3 moles of isophorone diisocyanate is added to the solution as an aliphatic isocyanate compound which will form a skeletal structure of urethane, and is maintained at 110 ° C while gradually increasing the temperature. 3 hours after the mixture of the isocyanate and the polyol is maintained at the above temperature, the NCO% present in the group of isocyanate is measured. When the temperature falls below 4.1% of the theoretical NCO%, the reaction is stopped by lowering the temperature using cooling water.

Here, ethanol (2-Octyldodecanol-1) and ethanol are added and diluted for smooth reaction between the prepolymer having a terminal NCO group and 1 mole of m-phenylenediamine and moisturizing during the final film formation. When a pre-prepared dilution of m-phenylenediamine: ethanol = 1: 4 weight ratio is prepared to the synthesized prepolymer, DROP CHARGE, m-phenylenediamine and isocyanate at the end of the prepolymer are polymerized by reaction. Colorless, transparent and viscous Liquid urethanes are synthesized.

Example  8

Using the liquid polyurethane prepared in Examples 1 to 7 to prepare a liquid band using the following method.

The prepared liquid urethane can be used directly, but the viscosity is not easy to use because it is not easy to use the ethyl acetate: ethanol = 1: 4 weight ratio dilution of 30 parts by weight based on the liquid urethane is used to dissolve. To improve adhesion, 1 part by weight of polyvinylpyrrolidone was added to the solution, and 2 parts by weight of menthol and 2 parts by weight of tea tree oil were added to impart aroma and soothing effect, respectively. For the moisturizing effect, 1 part by weight of castor oil, ethanol, pinsolve, petrolatum, and glycerin were added to the solution.

2 parts by weight of isopropyl alcohol, ethyl salicylate, and camphor were added and mixed homogeneously as a disinfectant, and then a liquid band was prepared and stored in a container that can be easily applied to the wound surface.

In addition, if necessary, one of the local anesthetics lidocaine, tetracaine, and benzocaine can be selected to mix 0.05 parts by weight to prevent pain, and one of the exfoliating agents alpha hydroxy acid and beta hydroxy acid can be selected. 5 parts by weight, at least one selected from the sunscreen paraaminobenzoic acid, oxybenzone, avobenzone, cinnamate derivatives, salicylic acid derivatives, homo salate, benzophenone, zinc oxide, titanium oxide, iron oxide, magnesium oxide Part was added.

Example  9

Using the liquid polyurethane prepared in Examples 1 to 7 are used directly as a liquid band. The prepared liquid urethane can be used directly, but the viscosity is not easy to use because it is not easy to use the ethyl acetate: ethanol = 1: 4 weight ratio dilution of 30 parts by weight based on the liquid urethane is used to dissolve.

Comparative example  One

Instead of the liquid band in the solution state prepared in Example 1, after the film was prepared using a nitrocellulose (Tokyo Gapza Co., Ltd., Tokyo Co., Ltd., JP), which is conventionally used as a liquid band, In the same way, the maximum stress value and the elongation rate were measured. The measurement results are shown in Table 1 below.

In addition, after the film was prepared in the same manner as in Example 1, the water resistance was measured, and as a result, it was confirmed that the dry filter was not wet as in Example 1.

Comparative example  2

Instead of the liquid band in the solution state prepared in Example 1, after the film was prepared using the acrylate (3M, USA) that is conventionally used as a liquid band, the maximum stress in the same manner as in Example 1 The maximum stress value and the elongation rate were measured. The measurement results are shown in Table 1 below.

In addition, after the film was prepared in the same manner as in Example 1, the water resistance was measured, and as a result, it was confirmed that the dry filter was not wet as in Example 1.

Comparative example  3

Instead of the liquid band in the solution state prepared in Example 1, after producing the film using the colloidion (Medtech, USA) that is used as a conventional liquid band, the maximum stress in the same manner as in Example 1 The maximum stress value and the elongation rate were measured. The measurement results are shown in Table 1 below.

In addition, after the film was prepared in the same manner as in Example 1, the water resistance was measured, and as a result, it was confirmed that the dry filter was not wet as in Example 1.

[Property evaluation]

1) Check the mechanical properties of the liquid band The tensile strength )

In order to check the physical properties of the prepared liquid band, the liquid band in a solution state was cast to a thickness of a predetermined size (100 μm) and dried at 37 ° C. for 5 minutes to prepare a film.

The prepared film was installed in an Instron tensile machine (ASTM D-638-03, Instron US 3360 series) and subjected to a tensile test. The measurement method was placed and fixed between the grip (grip) and the film made in the dog-bone form, the tensile test was carried out at a cross-head speed of 50mm / min, the maximum stress (maximum stress) Value and elongation were obtained. The measurement results are shown in Table 1 below.

2) Liquid band waterproof test

As in the tensile strength test method, the liquid band was made of urethane film, cut into 7 cm diameter, and 5 pieces were taken, and then left at 65% humidity and 20 ° C. for 2 hours or more. Then, the film and the dry filter paper (dry filter paper) fixed to the waterproof test device (Fig. 2) and filled with distilled water up to 500ml or more in the waterproof test device, the valve is opened to put water into the chamber (Chamber), The change in scale and the wet condition of the dry filter paper were observed for 5 minutes from when the scale was not changed.

 As a result, there was no change in scale of distilled water for 5 minutes, and it was confirmed that the dry filter paper was not wet and waterproof.

3) pH  Measure

The pH of Table 1 is to prepare a liquid band in the urethane film as in the tensile strength test method, and to measure the pH of the liquid eluted the film. The eluate is prepared by putting 20 ml of saline per 4 g of the prepared film and then eluting at 72 ° C. for 24 hours.

4) Moisture permeability  Measure-MVTR ( Moisture vapor transmission rate )

In order to measure the water vapor transmission rate of the prepared liquid band, a urethane film was prepared in the same manner as the tensile strength test, and then a test specimen was prepared by first preparing a circular test piece having a diameter of 70 mm. In order to measure the moisture permeability, the moisture permeable cup was placed on a horizontal moisture permeable cup stand, 20 g of calcium chloride, an absorbent, was placed in the moisture permeable cup, and the test specimen prepared in advance was concentrically placed on the moisture permeable cup. The weight was placed so that the test piece adhered to the edge of the moisture-permeable cup, and the melted paraffin solution was poured into the edge around the moisture-permeable cup to seal the edge of the test piece. After the paraffin solution has hardened, the cup to which the test piece is bonded is weighed with a balance and left for 24 hours at 85% humidity and 37 ° C. The moisture permeability divided by time is shown in Table 1 below.

As shown in Table 1, in the case of the film (Examples 1 to 9) made of urethane according to the present invention as a result of comparing the mechanical tensile strength with the conventional liquid bands (Comparative Examples 1 to 3), It was confirmed that the control of the maximum stress value and elongation can be made higher or lower than the conventional liquid band, which means that it is easy to control the properties of urethane.

And, as a result of MVTR measurement, the liquid bands (Comparative Examples 1 to 3) used in the present invention and the film made of urethane according to the present invention did not significantly differ in numerical value, all showed similar tendency in transmittance. Therefore, when the film according to the present invention is used for the wound site, the effect of protecting the wound of the skin from external stimuli is excellent.

In addition, the pH of the film (Examples 1 to 9) made of a urethane according to the present invention is close to neutral pH compared to the liquid bands (Comparative Examples 1 to 3) that are conventionally used. It can be seen that the features, and due to this feature is excellent in protecting the wound of the skin.

In addition, according to the waterproof test results, it was found that in the case of the films of Examples 1 to 9, the waterproof effect is also excellent.

Although the present invention has been described in detail with reference to the described embodiments, it will be apparent to those skilled in the art that various changes and modifications can be made within the scope and spirit of the present invention, and such modifications and modifications fall within the scope of the appended claims. It is also natural.

Claims (20)

Liquid band containing volatile solvent and polyurethane. The method of claim 1, The liquid band further comprises at least one selected from the group consisting of pressure-sensitive adhesives, fragrances, moisturizers, disinfectants, skin sedatives, local anesthetics, exfoliants and sunscreens. The method of claim 2, wherein based on 100 parts by weight of the polyurethane, 5 to 400 parts by weight of the volatile solvent, 0 to 5 parts by weight of the pressure-sensitive adhesive, 0 to 20 parts by weight of the fragrance, 0 to 20 parts by weight of the moisturizer, 0 to 10 parts by weight of the disinfectant, the skin sedative 0 to 10 parts by weight, 0 to 0.1 parts by weight of the local anesthetic, 0 to 15 parts by weight of the exfoliant, and 0 to 10 parts by weight of the sunscreen. The method of claim 1, After applying the liquid band on the skin, the liquid band characterized in that the urethane film is formed after the volatile component is volatilized. The method of claim 1, The volatile solvent is a liquid band, characterized in that at least one selected from the group consisting of ethanol, benzyl alcohol, isopropyl alcohol, ethyl acetate and acetone. The method of claim 2, The pressure-sensitive adhesive is a liquid band, characterized in that at least one member selected from the group consisting of polyvinylpyrrolidone and silicone. The method of claim 2, The perfume is liquid band, characterized in that at least one member selected from the group consisting of menthol, ethyl salicylate, castor oil, and tea tree oil. The method of claim 2, The moisturizing agent is a liquid band, characterized in that at least one selected from the group consisting of pinsolve, ethanol, petrolatum and glycerin. The method of claim 2, The disinfectant or skin sedative is a liquid band, characterized in that at least one selected from the group consisting of isopropyl alcohol, salicylic acid, and camphor. The method of claim 2, The local anesthetic is a liquid band, characterized in that at least one selected from the group consisting of lidocaine, tetracaine and benzocaine. The method of claim 2, The exfoliating agent is a liquid band, characterized in that at least one selected from the group consisting of alpha hydroxy acid and beta hydroxy acid. The method of claim 2, The sunscreen may be at least one selected from the group consisting of paraaminobenzoic acid, oxybenzone, avobenzone, cinnamate derivatives, salicylic acid derivatives, homosalates, benzophenones, zinc oxides, titanium oxides, iron oxides and magnesium oxides. Characterized by a liquid band. V) synthesizing polyurethane by mixing 0.8 to 1.2 moles of polyol, 0.8 to 1.2 moles of glycol, and 2.4 to 3.6 moles of aliphatic isocyanate compounds; And Ii) adding 5 to 400 parts by weight of a volatile solvent based on 100 parts by weight of the polyurethane to the synthesized polyurethane. The method of claim 13, In step ii), at least one selected from the group consisting of an adhesive, a fragrance, a moisturizer, a disinfectant, a skin sedative, a local anesthetic, an exfoliant, and a sunscreen is further added. With respect to 100 parts by weight of the polyurethane, 0 to 5 parts by weight of the pressure-sensitive adhesive, 0 to 20 parts by weight of the fragrance, 0 to 20 parts by weight of the moisturizer, 0 to 10 parts by weight of the disinfectant, 0 to 10 parts by weight of the skin sedative Adding 0 to 0.1 parts by weight of a local anesthetic, 0 to 15 parts by weight of an exfoliant, and 0 to 10 parts by weight of a sunscreen; Method for producing a liquid band comprising a. The method of claim 13, The polyol is a method for producing a liquid band, characterized in that at least one member selected from the group consisting of polyethylene oxide polyol, polypropylene oxide polyol and polyethylene propylene oxide copolymer polyol. The method of claim 13, The glycol is selected from the group consisting of ethylene glycol, propylene glycol, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, diethylene glycol, triethylene glycol, polyethylene glycol and polytetramethylene glycol Method for producing a liquid band, characterized in that one or more. The method of claim 13, The polyol and glycol is a method of producing a liquid band, characterized in that added in a weight ratio of 1.2: 1 to 1: 1.2. The method of claim 13, The aliphatic isocyanate compounds include isophorone diisocyanate, 1,6-hexamethylene diisocyanate, 1,5-naphthalene diisocyanate, 4,4-dicyclohexyl methane diisocyanate, 2,2,4-trimethyl A method for producing a liquid band, characterized in that at least one member selected from the group consisting of hexamethylene diisocyanate and 2,4,4-trimethylhexamethylene diisocyanate. The method of claim 13, The volatile solvent is a method for producing a liquid band, characterized in that at least one selected from the group consisting of ethanol, benzyl alcohol, isopropyl alcohol, ethyl acetate and acetone. 20. A liquid band made according to claim 13.