KR20190074115A - Highly Elastic Liquid Band And Manufacturing Method Thereof - Google Patents

Abstract

The present invention relates to a highly elastic liquid band, including water-dispersible polyurethanes as an active ingredient to form a coating layer upon application, wherein the water-dispersible polyurethanes include compounds with potential ionic groups and polyols. The liquid band, with viscosity of 2,000 to 5,000 cps at 25°C, is obtained by extending a polyurethane chain by inducing a reaction with an amine chain extender in an aqueous solution, after 10 to 50 parts by weight of an isocyanate compound is added to induce a reaction with 100 parts by weight of a mixed solution, followed by neutralization, which is then water dispersed in 120 to 300 parts by weight of deionized water (DIW) to obtain a polyurethane prepolymer water dispersion having an NCO end group.

Description

TECHNICAL FIELD [0001] The present invention relates to a high elastic elastic band,

The present invention relates to a high-elasticity liquid band and a method for producing the same, more specifically, to a high-elasticity liquid band capable of maintaining a wet environment by forming a coating on a wound area to protect a wound area and exudate from a wound, and a method for manufacturing the same.

Liquid bands are used to heal and protect small wounds, unlike ordinary bands that are tied to the skin, which is a mixture of volatile liquids and polymeric materials. The volatile liquid is volatilized and the polymeric material remains to form a film It is a mixture of chemicals with characteristics.

The liquid band protects the wound surface from external sources such as dust and germs, and keeps moisture inside to protect the wound.

Representative liquid bands include (i) water as a solvent, (ii) liquid bands prepared by using polyvinylpyrrolidone as a polymer, (ii) alcohol as a solvent, cellulose as a polymer or Nitrocellulose, methylacrylate isobutene monoisopropylmaleate, and the like; and iii) hexamethyldisiloxane or iso-octane solvent is used as the solvent, and acrylic, And a liquid band using a non-acrylate or siloxane polymer as the main raw material.

However, the conventional liquid band has a problem that when the film is formed or covered with a wound surface to protect the wound site, the film is not elastic enough due to the characteristics of the film, The motion of the liquid band is not good and it may cause local pain. In addition, the liquid band easily tears and re-use often occurs, resulting in an uneconomical problem. Therefore, development of a liquid band of a film having high elasticity is required.

Korean Patent Publication No. 10-1125162 entitled " Liquid Bands for Protecting Skin and Wounds and Method for Producing the Same "discloses a liquid dressing agent comprising a liquid polyurethane and a volatile solvent prepared by using a prepolymer synthesis method have. In this technique, a prepolymer having an NCO group at its end is reacted with a di-amine (DI-AMINE) compound during the prepolymer synthesis, and a diluting solvent containing ethyl acetate is added to dissolve the prepolymer well. In the case of this technique, ethyl acetate must be used for dissolving the prepolymer. However, the use of ethyl acetate has a problem of causing strong irritation and severe pain when applied to a wound.

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above-mentioned problems of conventional liquid dressing agents, and it is an object of the present invention to provide a liquid dressing composition containing no organic solvent or minimizing the use amount thereof.

Also, in the present invention, a liquid dressing agent is prepared by using a water dispersion type polymer solution using a large amount of water. In particular, it is an object of the present invention to provide a liquid dressing agent using water-dispersed polyurethane.

It is another object of the present invention to provide a liquid dressing agent which forms a coating of a thin polyurethane film having elasticity when applied on a wound surface to prevent contamination of the wound surface and protect water penetration by waterproof property .

It is another object of the present invention to provide a liquid dressing agent which can form a coating film in a suitable time during coating even when there is no skin irritation by using water-dispersed polyurethane dispersed in a large amount of water

Disclosure of the Invention In order to solve the above-mentioned problems, the present invention provides a water-dispersible polyurethane resin composition comprising 100 parts by weight of a water-dispersed polyurethane as an effective component for forming a coating upon application, 10 to 50 parts by weight of an isocyanate compound is reacted and neutralized and then water-dispersed in 120 to 300 parts by weight of deionized water (DIW) to obtain a polyurethane prepolymer aqueous dispersion having NCO end groups. Then, And has a viscosity of 2,000 to 5,000 cps at 25 DEG C, and a high elasticity liquid band.

The present invention also provides a high-elasticity liquid band, wherein the liquid band further comprises at least one selected from the group consisting of an adhesive, a fragrance, a moisturizer, a disinfectant, a skin sedative, a local anesthetic, an exfoliation agent and an ultraviolet screening agent.

The present invention also provides a high-elasticity liquid band comprising 100 parts by weight of the water-dispersed polyurethane, and 1 to 100 parts by weight of a solvent for viscosity control.

The present invention also relates to a process for preparing a polyurethane foam, which comprises the steps of (a) adding 10 to 50 parts by weight of an isocyanate compound to 100 parts by weight of a mixed solution containing a polyol and a compound having a potential ionic group, neutralizing the mixture after reacting and 120 to 300 parts by weight of DIW Water dispersion to obtain a polyurethane prepolymer dispersion having an NCO end group and then reacting with an amine-based chain extender in an aqueous solution to obtain a water-dispersed polyurethane by extending a chain of the polyurethane; (b) adjusting the viscosity of the water-dispersed polyurethane obtained in the step (a) to 2,000 to 5,000 cps.

The present invention also provides a method for preparing a highly elastic liquid band, wherein the viscosity is adjusted by mixing 1 to 100 parts by weight of a solvent for adjusting the viscosity with respect to 100 parts by weight of the water-dispersed polyurethane.

Also, the present invention provides a method for producing a highly elastic liquid band, wherein the solvent for adjusting the viscosity is at least one of deionized water (DIW), ethanol, and isopropyl alcohol.

The water-dispersed liquid dressing agent of the present invention is water-dispersed in a large amount of water and does not contain or at least contains an organic solvent which gives a stimulus to the wound, so that it is easy to use because there is little irritation and pain when applied to wound area Do.

In addition, since the evaporation rate is not greatly different from that of the conventional liquid dressing agent even in the form of water dispersion, a coating film can be formed in a suitable time during coating.

The liquid dressing agent of the present invention forms a thin polyurethane film in the form of a liquid, which is easy to use on a curved wound surface and has elasticity when applied to a wound surface. As a solid dressing agent, It protects the wound area and has a waterproof effect to prevent the penetration of water and to maintain the wet environment with exudates.

Hereinafter, preferred embodiments of the present invention will be described in detail. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted so as to avoid obscuring the subject matter of the present invention.

As used herein, the terms " about, " " substantially, " " etc. ", when used to refer to a manufacturing or material tolerance inherent in the stated sense, Accurate or absolute numbers are used to help prevent unauthorized exploitation by unauthorized intruders of the referenced disclosure.

Hereinafter, the present invention will be described in detail.

Disclosed is a water-dispersed polyurethane which comprises 10 to 50 parts by weight of an isocyanate compound in 100 parts by weight of a mixed solution containing a polyol and a compound having a potential ionic group as an effective component for forming a coating upon coating, (DIW) to obtain an aqueous polyurethane prepolymer having an NCO end group, and then reacting with an amine chain extender in the aqueous solution to elongate the polyurethane chain And has a viscosity of 2,000 to 5,000 cps at 25 ° C.

<Water-dispersed polyurethane>

The water-dispersed polyurethane which is the main polymer of the aqueous dispersion liquid dressing according to the present invention is prepared by reacting an isocyanate compound in a mixed solution containing a polyol and a compound having a potential ionic group, neutralizing it, ) To obtain a polyurethane prepolymer aqueous dispersion having an NCO end group and then reacting with an amine chain extender to obtain a polyurethane chain.

Preferably, 10 to 50 parts by weight of an isocyanate compound is added to 100 parts by weight of a mixed solution containing a polyol and a compound having a potential ionic group, followed by neutralization. The resulting mixture is neutralized by 120 to 300 parts by weight of water (DIW) To obtain a polyurethane prepolymer aqueous dispersion having an NCO end group. Then, the polyurethane chain is extended by reacting with an amine-based chain extender in the aqueous solution to obtain the water-dispersed polyurethane of the present invention. More preferably, 20 to 40 parts by weight of an isocyanate compound is added to 100 parts by weight of the mixed solution, and the mixture is dispersed in 150 to 250 parts by weight of deionized water (DIW) to obtain a polyurethane prepolymer aqueous dispersion.

In a preferred preparation example, a polyol, a diol and a compound having a potential ionic group (for example, dimethylol propionic acid (DMPA)) are first charged and heated to 90 ° C with stirring at a stirring speed of 100 RPM. Dimethylol propionic acid (DMPA) If it dissolves, isocyanate is added and reacted under nitrogen atmosphere until the NCO content (%) reaches the theoretical value. Then, the temperature of the reaction mixture was cooled to room temperature, neutralized by dropping the neutralizing agent, and then distilled water (DIW) was dropped while stirring at a stirring speed of 500 RPM to disperse the polyurethane prepolymer having an NCO end group . In order to extend the polyurethane chain of the obtained polyurethane prepolymer, an amine chain extender having the same stoichiometric ratio as the chain terminal NCO remaining unreacted was introduced and stirred at room temperature for 2 hours at a stirring speed of 200 RPM To give a water-dispersed polyurethane of the present invention. At this time, the amine chain extender is reacted in the form of an aqueous solution, and preferably the amine chain extender is reacted with the aqueous polyurethane prepolymer dispersion in an aqueous solution in which DIW is dissolved or dispersed. Preferably, 5 to 50 parts by weight of an amine chain extender in aqueous solution may be reacted with 100 parts by weight of the polyurethane prepolymer aqueous dispersion.

<Water-dispersed liquid dressing agent>

The water-dispersed polyurethane obtained above is subjected to a step of adjusting the viscosity to a range of 2,000 to 5,000 cps to be an aqueous dispersion liquid dressing composition (composition) of the present invention.

The step of adjusting the viscosity to the range of 2,000 to 5,000 cps includes a step of checking whether the viscosity of the obtained water-dispersed polyurethane is in the above range. In the present invention, a solvent for adjusting the viscosity may be separately added in order to control the viscosity of the water-dispersible polyurethane obtained as described above.

Preferably, the aqueous dispersion liquid dressing composition of the present invention comprises 100 parts by weight of the water-dispersed polyurethane and 1 to 100 parts by weight of a solvent for viscosity adjustment. Dispersed liquid dressing agent of the present invention is prepared by adding 1 to 100 parts by weight of a solvent for adjusting viscosity to 100 parts by weight of a water-dispersed polyurethane solution, and then using a high-speed stirrer or, preferably, a homogenizer. The solvent for adjusting the viscosity may be any one or more of, for example, deionized water (DIW), ethanol, isopropyl alcohol and acetone, and preferably at least one of DIW, ethanol and isopropyl alcohol. Ethanol or isopropyl alcohol may be used to impart a disinfecting effect to the liquid dressing agent with the viscosity control. However, when isopropyl alcohol is used in an amount capable of exhibiting a disinfecting effect, the viscosity of the dressing agent may be increased, which may result in difficulty in application. Therefore, ethanol is most preferably used to simultaneously impart the disinfecting effect with the viscosity control of the liquid dressing agent. At this time, ethanol is preferably mixed in an amount of 10 to 40 parts by weight based on 100 parts by weight of the aqueous dispersion polyurethane solution. When the ethanol is mixed, the water-dispersed polyurethane reacts with the hydrophilic functional group of the water-dispersed polyurethane to have an appropriate viscosity ranging from 2,000 to 5,000 cps. When the liquid dressing agent is applied to the wound, . If ethanol is used in an amount of less than 10 parts by weight, the disinfecting effect is lowered and the viscosity is lowered, and the problem of flowing on the wound surface may appear. On the other hand, when ethanol is used in an amount exceeding 40 parts by weight, irritation to a wound becomes strong and viscosity also becomes high, so that it is not easy to apply to a wound surface.

The aqueous dispersion liquid dressing composition of the present invention may further contain additives such as a fragrance, a moisturizer, an antibacterial agent, and an ultraviolet screening agent as necessary. In particular, the liquid dressing composition of the present invention may further include a fragrance to remove the amine odor peculiar to the water-dispersed polyurethane solution. Herb extracts such as menthol and lavender, flower extracts such as rose flowers and the like can be used as the aromatic agent, and the content thereof is 0 to 5 parts by weight, preferably 0 to 5 parts by weight, per 100 parts by weight of the water- 1 to 2 parts by weight.

Examples of the moisturizing agent include hyaluronic acid, amino acid, L-aspartic acid, sodium L-aspartate, DL-alanine, L- isoleucine, lysine hydrochloride, glycine, glycerin, L- glutamine, L- glutamic acid, L-threonine, sericin, serine, L-tyrosine, heparin, sodium chondroitin sulfate, sodium alginate, chitin and chitosan.

Examples of the antimicrobial agent include sulfodiamines such as povidone iodine, iodine, iodide ion salts, floramycin sulfate, acrynol, chlorohexidine chloride, benzalkonium chloride, benzenethonium chloride, etc. Can be used in a known capacity range (generally 0.05 to 5% by weight). In addition, drugs that are currently known to be efficacious for the purpose of wound healing and infection prevention, or drugs for which future efficacy can be identified, may be included.

As the ultraviolet screening agent, for example, p-aminobenzoic acid, oxybenzone, avobenzone, cinnamate derivatives, salicylic acid derivatives benzophenone, zinc oxide, titanium dioxide and the like can be used. The amount to be used is preferably 0 to 5 parts by weight, more preferably 1 to 3 parts by weight, based on 100 parts by weight of the water-dispersed polyurethane. If the amount exceeds 5 parts by weight, the physical properties of the urethane may be affected and the tensile strength may be weakened when the liquid dressing agent is filmed.

<Synthesis of polyurethane>

In the present invention, the polyurethane is synthesized by mixing 0.8 to 1.2 moles of polyol, 0.8 to 1.2 moles of glycol, and 2.4 to 3.6 moles of aliphatic isocyanate compound.

First, 0.8 to 1.2 moles, preferably 1 mole, and 0.8 to 1.2 moles, preferably 1 mole, of glycol are introduced into a polyol by the prepolymer synthesis method, and then the temperature is raised to 60 to 70 ° C with gentle stirring .

As the polyol, a polyethylene oxide polyol, a polypropylene oxide polyol, a polyethylene propylene oxide copolymerized polyol, polytetramethylene glycol, or the like can be used.

Examples of the glycol include ethylene glycol, propylene glycol, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, diethylene glycol, triethylene glycol, polyethylene glycol and polytetramethylene glycol .

The polyol and glycol are added in a weight ratio of 1.2: 1 to 1: 1.2, preferably 1: 1, in order to impart elasticity to the urethane film. The stirring temperature is maintained at 60 to 70 DEG C in order to maintain the reaction activation.

To the solution is added 2.4 to 3.6 moles, preferably 3 moles, of an aliphatic diisocyanate compound, and the temperature is maintained at 110 占 2 占 while gradually raising the temperature.

For example, when 3 moles of isocyanate is added to react, a prepolymer having 1 mole of terminal NCO groups can be produced.

The aliphatic diisocyanate compound is used to form the urethane skeleton. Specific examples thereof include isophorone diisocyanate, 1,6-hexamethylene diisocyanate, 1,5-naphthalene diisocyanate Isocyanate, 4,4-dicyclohexylmethane diisocyanate, 2,2,4-trimethylhexamethylene diisocyanate, 2,4,4-trimethylhexamethylene diisocyanate, and the like can be used.

In addition, the reaction does not proceed or the side reaction proceeds at a temperature outside the range of 110 占 占 폚, so that a desired urethane structure can not be obtained.

The NCO% present in the group of isocyanates was measured after 3 hours under the condition of maintaining the temperature of the mixture of isocyanate and polyol at the temperature (110 ± 2 ° C), and when the theoretical NCO% dropped to 4.1 or less, Lower

.

Then, to smoothly react the prepolymer having the terminal NCO group with the di-amines (DI-AMINE type) compound, dilute with ethyl acetate and ethanol. In order to increase the physical properties and viscosity of the synthesized urethane, the synthesized prepolymer is subjected to a drop charge (DROP CHARGE) in a state in which a diluted product of di-amines (DI-AMINE compounds): alcohol = 1: 1 by weight . At this time, a di-amine (DIAMINE) compound, which is a catalyst capable of accelerating the reaction rate between isocyanate and polyol, is reacted with the isocyanate at the end of the prepolymer to be polymerized.

The di-amines (DI-AMINE compounds) are reaction catalysts, and specific examples thereof include m-phenylenediamine, diethyltoluenediamine, methylmethiodotoluenediamine, etc. The alcohols include ethanol, isopropyl alcohol Can be used.

&Lt; Step of producing liquid bands >

A liquid band is prepared by adding a volatile solvent to the prepared polyurethane and adding at least one selected from the group consisting of a pressure-sensitive adhesive, a fragrance, a moisturizer, a disinfectant, a skin sedative, a local anesthetic, an exfoliation agent and an ultraviolet screening agent.

The volatile organic solvent is added to the polyurethane, and the content of the volatile organic solvent is preferably 5 to 400 parts by weight based on 100 parts by weight of the polyurethane. When the content is less than 5 parts by weight, the thickness of the urethane film becomes thick and the film is dried slowly, which limits the use of the film. When the content of the urethane is more than 400 parts by weight, the thickness of the film becomes thin.

Examples of the volatile solvent include ethanol, benzyl alcohol, isopropyl alcohol, ethyl acetate, and acetone.

A pressure-sensitive adhesive such as polyvinylpyrrolidone or silicone is added in order to impart an adhesive force to the solution. This adhesive improves adhesion to the skin during the formation of the urethane film. 10 parts by weight, preferably 1 to 3 parts by weight, and most preferably 1 part by weight.

0 to 20 parts by weight, preferably 1 to 10 parts by weight, based on 100 parts by weight of the polyurethane is used as a perfume for imparting a perfume to the liquid polyurethane. When the amount of the urethane is more than 20 parts by weight, the physical properties of the urethane may be affected and the elasticity may be lost when the urethane is made into a film. Mention may be made of menthol, ethyl salicylate, castor oil, tea trioyl, and the like.

In order to impart a moisturizing effect to the liquid polyurethane, 0 to 20 parts by weight, preferably 5 to 15 parts by weight, of a humectant based on 100 parts by weight of the polyurethane is used. If it exceeds 20 parts by weight, the physical properties of the urethane may be affected and the elasticity may be lost when the polyurethane is formed into a film. Examples of the moisturizing agent include C12-C15 Alkyl Benzoate, styrene, vaseline, and glycerin.

In order to protect and repair the wound, a disinfectant (skin soothing effect) or skin soothing agent that can be mixed with the organic solvent is added. As the disinfectant or skin soothing agent, isopropyl alcohol, salicylic acid, camphor, etc. may be used, and 0 to 10 parts by weight, preferably 2 to 5 parts by weight, are used relative to 100 parts by weight of the polyurethane. When the amount is more than 10 parts by weight, the volatilization rate is slowed and the filming proceeds slowly.

A local anesthetic is used to give pain relief to the liquid polyurethane. The content is 0 to 0.1 parts by weight, preferably 0.01 to 0.05 parts by weight, based on 100 parts by weight of the polyurethane. If the amount is more than 0.1 part by weight, the anesthetic time of the site becomes long, which may cause a trouble to the life. As the local anesthetic agent, lidocaine, tetracaine, benzocaine and the like can be used.

An exfoliant is used to impart exfoliation effect to the liquid polyurethane, and the content thereof is 0 to 20 parts by weight, preferably 5 to 15 parts by weight, based on 100 parts by weight of the polyurethane. If it exceeds 20 parts by weight, the physical properties of the urethane may be affected and the elasticity may be lost when the polyurethane is formed into a film. Examples of the exfoliants include alpha hydroxy acid, beta hydroxy acid, and the like.

An ultraviolet screening agent is used to impart ultraviolet ray blocking effect to the liquid polyurethane, and its content is 0 to 10 parts by weight, preferably 2 to 5 parts by weight, based on 100 parts by weight of the polyurethane. If it exceeds 10 parts by weight

It affects the physical properties of the urethane and may lose its elasticity when the polyurethane is filmed. Examples of the ultraviolet shielding agent include paraaminobenzoic acid, oxybenzone, avobenzone, cinnamate derivatives, salicylic acid derivatives, homosalate, benzophenone, zinc oxide,

Titanium oxide, iron oxide, magnesium oxide and the like can be used.

The present invention will be described in more detail through the following examples. However, these embodiments are merely illustrative and do not limit the technical scope of the present invention.

Claims (6)

Dispersible polyurethane as an active ingredient for forming a coating upon application,
The water-dispersed polyurethane is prepared by reacting 10 to 50 parts by weight of an isocyanate compound with 100 parts by weight of a mixed solution containing a polyol and a compound having a potential ionic group, neutralizing the reacted polyurethane and 120 to 300 parts by weight of deionized water Dispersed to obtain an aqueous polyurethane prepolymer having an NCO end group and then reacting with an amine-based chain extender in an aqueous solution to elongate the polyurethane chain, and having a viscosity of 2,000 to 5,000 cps at 25 ° C. Liquid band.
The method according to claim 1,
Wherein the liquid band further comprises at least one selected from the group consisting of an adhesive, a fragrance, a moisturizer, a disinfectant, a skin sedative, a local anesthetic, an exfoliation agent, and an ultraviolet screening agent.
The method according to claim 1,
Further comprising 1 to 100 parts by weight of a solvent for adjusting viscosity with respect to 100 parts by weight of the water-dispersed polyurethane.
(a) 10 to 50 parts by weight of an isocyanate compound is added to 100 parts by weight of a mixed solution containing a polyol and a compound having a potential ionic group, followed by neutralization. The resulting mixture is neutralized and dispersed in 120 to 300 parts by weight of deionized water (DIW) Obtaining a polyurethane prepolymer dispersion having a terminal group and then reacting with an amine-based chain extender in an aqueous solution to obtain a water-dispersed polyurethane by extending a chain of the polyurethane; (b) adjusting the viscosity of the water-dispersed polyurethane obtained in (a) from 2,000 to 5,000 cps.
5. The method of claim 4,
Wherein the viscosity control step comprises mixing 1 to 100 parts by weight of a solvent for adjusting viscosity with respect to 100 parts by weight of the water-dispersed polyurethane.
5. The method of claim 4,
Wherein the solvent for adjusting the viscosity is one or more of deionized water (DIW), ethanol, and isopropyl alcohol.