KR20100089370A - Novel polyene gene cluster from pseudonocardia autotrophica - Google Patents

Abstract

PURPOSE: A polyene biosynthesis gene group of Pseudonocardia autotrophica is provided to enhance productivity of Pseudonocardia autotrophica. CONSTITUTION: A Pseudonocardia autotrophica polyene biosynthesis gene is denoted sequence number 1. The Pseudonocardia autotrophica polyene biosynthesis gene comprises: a Pseudonocardia autotrophica modula PKS(polyketide synthase) gene, mycosamine generation protein, 4-phosphopantheteine transferase, cytochrome P-450 monooxygenase, ABC transporter, thioesterase, decarboxylase, ferredoxin protein, and a gene encoding the transcription regulation protein.

Description

Novel polyene gene cluster from Pseudonocardia autotrophica

The present invention relates to a group of genes for nucleotide synthesis of Pseudonocardia autotrophica and its sequencing.

Polyene antibiotics with antifungal and antiviral activity have a large macrorolactone ring structure, usually consisting of 20 to 40 carbons, and contain about 3 to 8 conjugated double bonds in the molecule. Typical type I polyketide macrolide compounds.

Polyketides are compounds synthesized from 2-carbon units through a series of condensation and subsequent modifications under the action of polyketide synthetases, and are produced by some bacteria, including fungi and actinomycetes (Robinson, JA, Philos. Trans. Soc.Lond.B.Biol.Sci. , 332: 107-14, 1991; Hopwood, DA, Curr. Opin.Biotechnol., 4: 531-537, 1993). Polyketide is a physiologically active molecule with a wide variety of structures, and has been found throughout microorganisms, fungi, plants, etc., and is widely used in clinical applications such as antibiotics (erythromucin, tetracycline, rifaycin), antifungal agents (amphotericine B), and anticancer drugs (daunorubicin, In addition to epothiolone, immunosuppressants (FK-506, rapamycin) and hyperlipidemia (lovastatin), polyethers such as monensin for livestock and agriculture, insecticides (spinosin, and averectectin) Bioactive substances.

In general, the production method using such a polyketide in its natural state is difficult to use industrially because of its low efficiency, and there are also many economic and technical difficulties in producing the polyketide compound by a conventional chemical method.

Due to these concerns, studies have been conducted to efficiently biosynthesize polyketides in the natural state, and recombinant production methods using related genes have begun to be developed. In other words, cloning, analysis, and manipulation using recombinant techniques of genes encoding polyketide biosynthetic enzymes have been carried out, and these techniques result in higher levels than those occurring in nature or hosts that do not produce polyketides. Production of polyketides became possible (WO 93/13663; 95/08548; 96/40968; 97/02358; 98/27203; and 98/49315; US 4,874,748; 5,063,155; 5,098,837; 5,149,639; 5,672,491; 5,712,146; 5,830,750 5,843,718; Fu, H. et al., Biochem., 33: 9321-6, 1994; McDaniel, R. et al., Science , 262: 1546-50, 1993; Kuhstoss, S. et al. Gene . 183 : 231-6, 1996).

Natural polyketides are synthesized by the successive activities of 50 different enzymes, called polyketide synthase (PKS), and carrier proteins, similar to the synthesis of fatty acids (Robinson, JA, Philos . Trans.R. Soc. Lond.B. Biol. Sci ., 332: 107-14, 1991; Hopwood, DA, Curr. Opin.Biotechnol., 4: 531-7, 1993).

There are two types of PKS: one is modular and the other is iteractive (Khosla, C., Chem. Rev. , 97: 2577-90, 1997). Modular PKS (type I) involves all the steps of assembling and modifying polyketide carbon chains by different catalyst sites, whereas repetitive PKS (type 2) uses one catalyst site more than once on the biosynthetic pathway. A typical modular PKS consists of several large polypeptide chains, which are divided into a loading module, multiple modules, and a relaxation module from the N-terminus to the C-terminus ( Hopwood and Sherman, Annu. Rev. Genet ., 24: 37-66, 1990). The load module consists of an acyl-transferase (AT) and an acyl carrier protein (ACP). In addition, the multiple expansion module basically includes ketosynthase (KS), AT, ACP, and in addition to the basic module may include an enzyme that modifies the β-carbon of the elongated polyketide chain. Finally, the release module may include thioesterase (TE) and, in some cases, cyclase activity.

Most polyene antibiotics reported to date are biosynthesized by actinomycetes, which are soil microorganisms, and form channels by combining with sterols present in fungal cell membranes such as K ⁺ and Mg ²⁺ . It has been shown that it possesses excellent antifungal activity by causing intracellular components to leak out of cells, causing metabolic disorders of fungi such as fungi and yeast (Aparicio, JF et al., Appl Microbiol Biothchnol . 61, 179-). 188, 2003; Zotchev, SB, Curr Med Chem. 10, 211-223, 2003). Recently, biopesticides derived from microorganisms are harmless to humans and can control pests and minimize environmental pollution. Research into polyene is being actively conducted as a substitute for.

As mentioned above, the acquisition of new polyenes may not only be usefully used as polyene antibiotics with antifungal and antiviral activity per se, but also to increase the productivity of new polyenes through some modification of the polyene gene sequence or to produce new polyenes. As it can be used for the production of one polyene-producing variant, it is very urgent to identify a novel polyene biosynthesis gene.

Actinomycetes are representative gram-positive soil microorganisms that form spores, form filamentous mycelium, and undergo unique morphological differentiation according to changes in the surrounding environment, and produce various kinds of useful physiologically active substances such as antibiotics and anticancer agents.

In particular, the rare actinomycetes Pseudonocardia autotrophica is a strain having a function of vitamin D3 hydroxylase and is known as a very useful strain in connection with bioactive substance modification. However, Pseudo norcadia autotrophica has few ecological and genetic studies on the microorganisms because of the minimal presence of actinomycetes and very difficult survival or culture conditions, and the base of genes involved in polyene biosynthesis. The sequence was not reported.

Therefore, the present inventors have made intensive studies to identify genes involved in novel polyene biosynthesis in Pseudonocadia autotrophica. As a result, the present inventors have identified a novel gene group using the Pseudonocadia autotropha cosmid library and confirmed the characteristics of the nucleotide sequence. The present invention has been completed by elucidating.

An object of the present invention is to provide a gene group for nucleotide synthesis of Pseudonocardia autotrophica and its base sequence.

In order to achieve the object of the present invention, the present invention is Pseudonocardia autotrophica polyene biosynthesis gene cluster represented by the nucleotide sequence of SEQ ID NO: 1, PKS (polyketide synthase) of Pseudonocardia autotrophica And amino acid sequences of SEQ ID NOs: 2 to 24 related to polyene biosynthesis.

The new polyene material to be biosynthesized in the gene group of the present invention is referred to as Cryptic Pseudonocardia Polyene (hereinafter CPP).

More specifically, the present invention relates to a polyketide (PKS) gene, a mycosamine producing protein, 4-phosphopantheteine transferases, and cytochrome P-450 monooxygenase (cytochrome P-). Genes encoding 450 monooxygenase, ABC transporter, thioesterase, decarboxylase, ferredoxin protein, and transcriptional regulator protein are all included.

The present invention provides the entire base sequence of Pseudonocardia autotrophica polyene biosynthetic gene cluster represented by the base sequence of SEQ ID NO: 1. SEQ ID NO: 1 refers to cppA, cppB, cppC, cppDI, cppDII, cppDIII, cppE, cppF, cppG, cppH, cppL, cppM, cppM, which are involved in Pseudonocardia autotrophica polyene biosynthesis A gene sequence of 125,717 bp with 23 open reading frames consisting of cppN, cppO, cppRI, cppRII, cppRIII, cppRIV, cppRV and cppRVI.

In the present invention, the polyketide (PKS) gene is a modular (type I) PKS, which represents a polyketide synthetase of cppA, cppB, cppC, cppI, cppJ and cppK, ketosynthase (KS), acyl transferase (AT) ), acyl carrier protein (ACP), ketoreductase (KR), dehydrate (DH) and enoylreductase (ER) domains.

The invention also

(a) an amino acid sequence consisting of the KS , AT, ACP regions of SEQ ID NO: 13;

(b) an amino acid sequence consisting of the KS1, mAT1, KR1, ACP1, KS2, mAT2, KR2, ACP2 regions of SEQ ID NO: 14;

(c) KS3, AT3, DH3, KR3, ACP3, KS4, AT4, DH4, KR4, ACP4, KS5, AT5, DH5, ER5, KR5, ACP5, KS6, AT6, DH6, KR6, ACP6, KS7 , Amino acid sequence consisting of AT7, DH7, KR7, ACP7, KS8, AT8, DH8, KR8, ACP8 region;

(d) KS9, AT9, DH9, KR9, ACP9, KS10, AT10, KR10, ACP10, KS11, mAT11, KR11, ACP11, KS12, AT12, KR12, ACP12, KS13, AT13, KR13, ACP13, KS14 , Amino acid sequence consisting of AT14, KR14, ACP14 region;

(e) an amino acid sequence consisting of the KS15, AT15, DH15, ER15, KR15, ACP15, KS16, AT16, KR16, ACP16, KS17, AT17, DH17, KR17, ACP17 regions of SEQ ID NO: 7; And

(f) The present invention provides a modular PKS (polyketide synthase) of Pseudo norcadia autotrophica comprising an amino acid sequence consisting of KS18, AT18, DH18, KR18, ACP18, and TE18 regions of SEQ ID NO: 8, and a gene encoding the same.

Since KR12 and KR13 are inactive in the KR domain of the modular PKS (polyketide synthase), the polyene of the present invention has a structural difference from nystatin. The gene encoding the amino acid sequence of SEQ ID NO: 7 was cppJ, which was analyzed as a very large gene encoding a protein of 5425aa with three modules. All AT domains of cppJ were found to contain acetate-specific AT (FIG. 3). Comparing the conserved motif of the DH domain of cppJ confirmed that DH15 is active, and in the case of DH17, the conserved histidine residue is changed to proline, indicating that it is inactive DH. 3). cppK is the last 18th module of the modular polyketide synthase (PKS), with one DH present, and for DH 18 glutamic acid, a conserved histidine residue at the active site HXXXGXXXXP (944th residue of SEQ ID NO: 8) (glutamic acid), and at the end is the thioesterase gene that cyclizes the backbone of the polyene. 4 is a diagram illustrating the analysis of the PKS sequence.

In the present invention, cppDI, cppDII and cppDIII are genes encoding mycosamine, a sugar part of polyene, and the sugar part of polyene is known to play a very important role in antifungal activity. The cppDI gene encodes 489aa long UDP-glycosyltransferase, and its protein is known to attach the generated mycosamine to the polyene backbone. The cppDII gene encodes a 352aa long aminotransferase and is known to play an important role in producing mycosamine. Finally, the cppDIII gene encodes 344aa long GDP-mannose-4,6-dehydratases, which are known to play an important role in producing mycosamine. . These three genes will be involved in binding mycosamine to the backbone of the polyene.

In the present invention, cppL was found to be a gene encoding cytochrome P-450 monooxygenase, which appears to hydroxylate carbon 10 of CPP. cppN, like cppL, has also been identified as a gene encoding cytochrome P-450 monooxygenase, which appears to hydroxylate carbon number 16 in CPP.

The cppH and cppG genes were analyzed to encode ABC transporters, and these proteins are expected to release CPP out of the cells, and the cppF gene is a 4-phosphopantheteine transferase (4-Phosphopantheteine transferases). ), The protein appears to be responsible for Post translational PKS modification.

cppE, located downstream of cppC, encodes a thioesterase and shows very high similarity (69% identity) to nysE of nystatin. The thioesterase is an extension unit in the chain elongation process of polyketide, unlike thioesterase which is located at the carboxyl end of PKS. Known as 'Proof-reading' (Reynolds, K. A et al., J. Biol. Chem , 277 (50): 48028-48034, 2002).

Sequence analysis of cppO located downstream of cppRIII shows a very high similarity (77% identity) with orf1 encoding putative acyl CoA decarboxylase and upstream of fredericamycin, and also ghrG (73 % identity) and jadN (72% identity) also show very high similarity. The genes of this family are similar to the transcarboxylase involved in malonyl CoA biosynthesis and are known to positively affect jadomycin productivity (Vining, L. C et al, Microbiology, 146). (4): 903-910 2000).

cppM was upstream of cppRIV and showed 35% identity to the N-terminal portion of 4Fe-4S ferredoxin in Kineococus radiotolerans SRS30216. No other genes were found. Generally, there is a ferredoxin gene in a polyene compound, but sequence analysis in the Pseudonocardia autotrophica polyene biosynthesis gene group of the present invention shows that cppM is a common polyene ferredoxin ( It was confirmed that the similarity with the ferredoxin gene in the actinomycetes including ferredoxin gene, and the poly-10 biosynthesis process by methyl nysN in the process of polyene biosynthesis under the influence of ferredoxin (ferredoxin) The carboxylation step in which the group is converted to COOH is unlikely to occur during the post-PKS modification process (FIG. 5).

As a result, due to the difference in the structure of the ferredoxin of the Pseudonocardia autotrophica polyene of the present invention, there is a difference in the overall polyene structure with conventional polyenes such as Nystatin. The polyene antifungal substance shows a large difference in activity and toxicity even with a small structural difference.In the case of amphotericin, the analogue in which the carboxyl group of the polyene is substituted with the methyl group is reduced by about 33 times compared to the conventional amphotericin. (Caffrey, P. et. Al., J Biol Chem , 280 (41): 34420-34426 2005), because the ferredoxin according to the present invention will not play a role in the polyene biosynthesis process of the present invention The new polyene is expected to have an advantageous structure compared to the conventional polyene antifungal material used in the existing industry (Fig. 7).

In silico analysis showed that the polyene biosynthesis regulatory genes all had a structure very similar to that of nystatin and amphotericin biosynthesis regulatory genes. In the present invention, the genes encoding the transcriptional regulatory proteins, cppR I and cppRII, respectively, were identified. , cppRIII, cppRIV, cppRV and cppRVI. cppRI, cppRII, and cppRIII are located downstream of cppE encoding thioesterase, and sequencing results show that transcription of a number of large ATP-binding regulators of the LuxR (LAL) family, including nysRⅠ, nysRII, nysRIII It has been confirmed that it has high homology with transcriptional activator. Analysis of the expected structures of the cppRI, cppRII, and cppRIII polypeptides revealed that they all had LuxR type HTH DNA binding motifs in the C-terminal region, while cppRI and cppRIII had Walker A and Walker in the N-terminal region. It has a B NTP binding motif (FIG. 6A).

cppRIV is located upstream of cppO and has similarity (45% identity) with nysRIV. As a result of sequencing, it was confirmed that there is a PAS-like domain in the N-terminal portion of CppRIV and that an HTH motif of LuxR type exists in the C terminal portion (FIG. 6A). In addition, cppRV and cppRIV present in the upstream portion of cppM encoding the ferredoxin gene also include LuxR type HTH motif in the C-terminal region, and CppRV in the N-terminal region, Walker A and It was confirmed that it has Walker B NTP binding motif. (Figure 6A)

As a result of the sequencing analysis, it was confirmed that the transcriptional regulatory proteins cppRI, cppRII, cppRIII and cppRIV were very similar to nystatin biosynthetic regulatory proteins NysRI, NysRII, NysRIII and NysRIV, respectively (Fig. 6B), NysRI, NysRII, NysRIII and NysRIV is known to act as a transcriptional activator for nystatin biosynthesis (Zotchev, S. B et al, J Bacteriol , 186, 1345-1354, 2004), CppRI, CppRII, CppRIII and cppRIV also appear to act as transcriptional activators in the polyene biosynthesis of the present invention.

The gene sequence according to the present invention can be used to increase the productivity of the existing Pseudonocardia autotrophica polyene through some modification or to prepare a variant of the novel Pseudonocardia autotrophica polyene. The novel polyenes of Pseudonocardia autotrophica according to the present invention can be usefully used as polyene antibiotics having antifungal and antiviral activity.

Hereinafter, preferred examples and experimental examples are presented to help understand the present invention. However, the following Examples and Experimental Examples are provided only to more easily understand the present invention, and the contents of the present invention are not limited by the Examples.

Example 1 Strain and Plasmid Culture Method

The strain used in this experiment was pseudotocardia autotrophica KCTC9441, grown in mycelium state in R2YE liquid medium, and stored frozen at -20 with 20% glycerol stock. To obtain the cells to be used for the isolation of genomic library of Pseudotocadia autotrophica, stocks were added to YEME (Sucrose 340g, Yeast extract 3g, Bacto-peptone 5g, Malt extract 3g, Glucose 10g, DW 1L) liquid medium. Inoculated sufficiently.

After incubating at 28 ° C. for 5 days, the cells were harvested using a centrifuge (8000 rpm). E. coliDH5 α, used for cosmid library construction and cloning, was grown in LB medium (0.5% yeast extract, 1% tryptone peptone, 0.5% NaCl, 0.1% glucose) and, if necessary, the antibiotic apramycin (apramycin). Culture was performed in LB medium to which 50 μg / ml or 100 μg / ml of ampicillin was added.

Example 2 Cosmid Library Preparation

Cosmid libraries are described in Streptomyces-E. It was produced using the colishuttle cosmid vector pOJ446. The pseudo Sat Arcadia auto trophy whole chromosome from car cultured in YEME (total chromosomal DNA) for the pure separation, was cloned DNA fragment than 40kb After treatment with EcoRV the pOJ446, making recombinant colonies is 10 ⁴ or more the concentration (titer ) Has been confirmed.

Example 3 Cosmid Screening for Polyene Biosynthesis

As a microplate reader, cultivated recombinant colonies using Bioscreen C (Transgalatic Ltd., Finland), which analyzes the growth of microorganisms by measuring changes in OD (Optical density) values during microbial growth, and then isolates the recombinant cosmid DNA. As a template, CYP degenerated primers (SEQ ID NOs: 25 and 26) and PCR experiments (denaturing [96, 30 seconds], annealing [40, 30 seconds], extention [72, 35 seconds], 30 cycles) were performed. CYP degenerated primers were made to order from Xenotech (Korea), including mixed bases. About 1000 recombinant colonies were additionally screened by this PCR-based method. As a result of screening approximately 1000 recombinant colonies by PCR, four recombinant cosmids amplified with 350 bp DNA fragments, the central region of CYP, were obtained, and they were named pESK601, pESK611, pESK612, pESK621, and pESK622, respectively.

CYP forward primer: TGGATCGGCGACGACCGSVYCGT (SEQ ID NO: 25)

CYP reverse primer: CCGWASAGSAYSCCGTCGTACTT (SEQ ID NO: 26)

S: (G / C); V: (A / G / C); Y: (T / C); W: (T / A)

Example 4 PKS Gene Sequence Analysis from Cosmid Clones

Sequence analysis of cosmids selected by PCR was performed by Xenotech using a shotgun approach, and each DNA sequence was assembled using a National Center for Biotechnology Information (NCBI) BLAST search. Also, according to the codon bias information of Streptomyces DNA, it was analyzed using web-based program Frameplot 2.3.2 (http://www.nih.go.jp/~jun/cgi-bin/frameplot.pl). The analysis was performed using a web site program Modular Polyketide Synthase Databae (http://linux1.nii.res.in/~pksdb/DBASE/page.html).

The analysis results for each gene are as follows. SEQ ID NO: 1 is cppA, cppB, cppC, cppDI, cppDII, cppDIII, cppE, cppF, cppG, cppH, cppL, cppM, cppM, involved in Pseudonocardia autotrophica polyene biosynthesis A gene sequence of 125,717 bp with 23 open reading frames consisting of cppN, cppO, cppRI, cppRII, cppRIII, cppRIV, cppRV and cppRVI.

In the present invention, six polyketide (PKS) genes are modular (type I) PKS, which represent polyketide syntheses of cppA, cppB, cppC, cppI, cppJ and cppK, ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydrate (DH) and enoylreductase (ER) domains. The base sequence and amino acid sequence of each PKS gene are summarized in Table 1.

Base sequence and amino acid sequence position of each PKS gene gene Region in SEQ ID NO: 1 Corresponding amino acid sequence number cppA 62823-66116 13 cppB 66162-75689 14 cppC 75724-108354 15 cppI  6673-35172 6 cppJ 35193-51470 7 cppK 51508-57603 8

cppA encodes a loading module, and in the case of amino acid sequence regions for the PKS domain of cppA, M.-Y. Lee et al., Isolation and partial characterization of a cryptic polyene gene cluster in Pseudonocardia autotrophica.J Ind Microbiol Biotechnol 33 (2): 84-87, 2005).

cppB codes modules 1 and 2, has KS1, mAT1, KR1, ACP1, KS2, mAT2, KR2, and ACP2 regions, and summarizes the key sequences of the PKS domain in Table 2.

cppC codes modules 3 4, 5, 6, 7 and 8, KS3, AT3, DH3, KR3, ACP3, KS4, AT4, DH4, KR4, ACP4, KS5, AT5, DH5, ER5, KR5, ACP5, KS6 , AT6, DH6, KR6, ACP6, KS7, AT7, DH7, KR7, ACP7, KS8, AT8, DH8, KR8, ACP8 region, the key sequences of the PKS domain are summarized in Table 3.

cppI codes modules 9,10,11,12,13 and 14, KS9, AT9, DH9, KR9, ACP9, KS10, AT10, KR10, ACP10, KS11, mAT11, KR11, ACP11, KS12, AT12, KR12, Table 4 shows the key sequences of the PKS domain, which has the ACP12, KS13, AT13, KR13, ACP13, KS14, AT14, KR14, and ACP14 regions.

cppJ codes modules 15, 16, and 17, has regions KS15, AT15, DH15, ER15, KR15, ACP15, KS16, AT16, KR16, ACP16, KS17, AT17, DH17, KR17, ACP17, and the core sequences of the PKS domain Are summarized in Table 5.

cppK codes module 18, has KS18, AT18, DH18, KR18, ACP18, TE18 regions, and summarizes the key sequences of the PKS domain in Table 6.

Key Sequences of the PKS Domain of cppB domain Key sequence mAT1 ALDELGAVLDGEGIRVRRVAVDYASHSHQVEELRAEILETLAGLSPQPSAVPLYST KR1 RGTTLVTG G S G TL A PDL A RRLAADGAEHVV L L SR R- G PE mAT2 ALDALLPACESAGVRARRVSVDYASHGPHVEAVRDELAEVLAGITPRTPTVPFYST KR2 RGTVLVTG G T G GI G GRT A VWAAGRGAEHLL L T SR R- G ED

Key Sequences of the PKS Domain of cppC domain Key sequence domain Key sequence AT3 GIAAVEEHARARGWRSTRLRVSHAFHSPLMEPMLAEFRAVAAGLTYHEPRIPVVSN AT6 AVLAVAEQLRAQGRSVTTLRVSHAFHSPLMDPMLEEFRAVAEQLTYTEPVVPVVSN DH3 RLSVRTHPW L AD H GVQ G RALL P GTAFVELAVRAGDEVG DH6 RISTRTQPW L AD H AVG G RVLL P GTAFVELVLRAGEEVG KR3 DGTVLITG G T G GL G GVL A RHLVAEHGVRQLL L A GR R G PD KR6 AGTVLVTG G T G GL G AVL A RHLVAAHDVRELL L V SR R G PD AT4 GVDAVAAALAEGGRRTSRLRVSHAFHSPLMEPMLAEFRSVVAGLSPEAPAVPVVSS AT7 AVREVAARFTADGHRATALRVSHAFHSPLMDPMLSEFGAVAAGITYREPSIPVVSN DH4 RLSASAQPW L AD H TVA G TVVL P GTALLELAVRAGDEVG DH7 RMSLRTHPW L AD H TVA G RVVV P GTALLEMAVRAGDEVG KR4 EGTVLVTG G T G GL G GLL A RHLVATHGVRHLL L T SR S G AD KR7 DGTVLVTG G T G GL G AQL A RHLVEVHGVRHLV L A SR R G AD AT5 AVTAVGEQL--AGRRTRRLAVSHAFHSPLMDPMLAEFRAVAEQLSYAEPVVPVVSN AT8 AVLAVGTRLAEQGRRTTRLQVSHAFHSPLMDPMLEGFRAVAERLTYAEPVVPVVSN DH5 RLSLATHPW L TD H AVR G TVLV P GTALLELALRAGDEVG DH8 RLSRGSHPW L VD H TVL G HVLV P GTALLDMAIRAGDQVG ER5 EKVLVHAGA GGVG M AA V Q I A RHLGAEVYATASEPKQHVL KR8 DGTVLVTG G T G GL G SLV A RHLVTGRGVRDLV L A GR R G PS KR5 EGTVLVTG G T G GL G GLL A RHLVATHGVRHLL L T SR S G AD

Key Sequences of the PKS Domain of cppI domain Key sequence domain Key sequence AT9 AVTAVAGLLADQGRRTRRLRVSHAFHSPLMEPMLDEFRAVVEGLDLQAPLIPIVSD AT12 EVDAVAARLAAQGRRTHRLRVSHAFHSPLMEPMLDEFRAVVSGLDYAAPAIPIVST DH9 RLSLQTHPW L AD H TVR G TTLL P GTAFLELAVRAGDEVG KR12 TGTVLITG G T G GI G GHV A RRLAREGAAHLL L A A R R-GPD KR9 DGAVLVTG G T G GL G AVV A RHLATTHGVTDLL L V GR R G PA AT13 GVGALADRLAADGRRTRRLRVSHAFHSPLMDAMLDGFAAAISGITFAAPRIPLVST AT10 ATAALAATFAEQGRRTRTLRVSHAFHSPHMDGMLEDFRAVAERIEYHAPRIPVVSN KR13 HGTVLVVG G T G AL G RRA A RRLAADGATHLV L T AP S- A AA KR10 TGSVLVTG G T G GL G AEV A RWLARSGVAHLV L T SR R- G PD AT14 AVTALAAVLAGEGRRTSRLQVSHAFHSARMDPMLAEFRTVAEELDYHEPRIPVVSN mAT11 ALDELLAAFDAADVRARRIAVDYASHSHQVEDLRDELATTLAGLAPQPSQVPVFST KR14 TGTVLITG G T G AL G GHV A RRLAADGAQHLV L L GR R- G PD KR11 RGTTLVTG G S G TL A PHL A RRLAERGAEHVV L L SR R- G PD

Key Sequences of the PKS Domain of cppJ domain Key sequence domain Key sequence KS15 QGTVLITG G T G GL A AAL A RHLVATHGVAHLL L A GR R G PD KR16 SGTVLITG G T G AL G GHV A RRLAADGAEHLV L L GR R- G PD AT15 ATLAVAARLAEQGRRTSRLRVSHAFHSPLMDPMLAEFAAVAEGLSYAEPRIPLVST AT17 EVSAVADALAARGCRTRALRVSHAFHSPLMEPMLDGFDVVAGLNPVEPRIPVVST DH15 TLSLTTHPW L AD H VVG G MVFF P GTGFLELAVRAADQAG DH17 RLT ---- PT L VD P AAG D LPAL P AAVLAELAVRAGDEAG ER15 EKVLIHAGA GGVG M AA V Q I A HHLGAEVYATASEPKQDVL KR17 DGTVLVTG G T G GL G ALL A RHLVTTRGVRHLL L A GR R G PD AT16 EVDAVAAELAARGRRTTALRVSHAFHSPLMDPVLDEFRAVVRDLGYELPAIPVVSL

Key Sequences of the PKS Domain of cppK domain Key sequence AT18 AVAAVAARFEDRGRRIRTLSVSHAFHSPLIDPMLAEFARVVDGLTFAEPRIPVVSN DH18 RLSPRTQPW L GP E RTD G RVDV P GAVFAELAIRAGDQVG KR18 DGTVLVTG G T G GL G ALL A RHLVTTGRTRNLL L A SR R G PD

The conserved sequences of the key sequences are expressed in underlined bold letters.

Table 7 summarizes the functions of proteins encoded by genes involved in Pseudonocardia autotrophica polyene biosynthesis.

Comparison of the Functions of Proteins Encoded by Pseudonocardia autotrophica Polyene Biosynthesis and Homology with nystatin Biosynthesis Genes SEQ ID NO: Protein aa Proposed Function Homologs, Origins Identities, Positives (%) 2 CppF 224 Phosphopantheteine transferase NysF , Streptomyces noursei 63,73 3 CppG 592 ABC transporter NysG , Streptomyces noursei 75,83 4 CppH 584 ABC transporter NysH , Streptomyces noursei 76,84 5 CppDIII 345 GDP-mannose-4,6-dehydratase NysDIII , Streptomyces noursei 89,93 6 CppI 9499 Type I PKS NysI , Streptomyces noursei 73,80 7 CppJ 5425 Type I PKS AmphJ , Streptomyces nodosus 61,67 8 CppK 2031 Type I PKS NysK , Streptomyces noursei 64,69 9 CppL 403 P450 monooxygenase NysL , Streptomyces noursei 68,77 10 CppN 413 P450 monooxygenase NysN , Streptomyces noursei 74,83 11 CppDII 352 Aminotransferase NysDII , Streptomyces noursei 82,90 12 CppDI 489 Glycosyltransferase NysDI , Streptomyces noursei 79,85 13 CppA 1097 Type I PKS NysA , Streptomyces noursei 62,69 14 CppB 3175 Type I PKS NysB , Streptomyces noursei 71,78 15 CppC 10876 Type I PKS NysC , Streptomyces noursei 71,77 16 CppE 274 Thioesterase discrete thioesterase , Streptomyces nodosus 77,83 17 CppRI 946 Regulation NysRI , Streptomyces noursei 45,58 18 CppRII 765 Regulation FscRIV , Streptomyces sp. FR-008 35,44 19 CppRIII 925 Regulation NysRIII , Streptomyces noursei 38,48 20 CppO 526 Decarboxylase putative acyl CoA decarboxylase , Streptomyces griseus 77,85 21 CppRIV 213 Regulation ORF4 , Streptomyces noursei 45,66 22 CppM 138 Ferredoxin 4Fe-4S ferredoxin , Kineococus radiotolerans SRS30216 35,45 23 CppRV 963 Regulation FsCRII , Streptomyces sp. FR-008 35,46 24 CppRVI 684 Regulation FscRII , Streptomyces sp. FR-008 32,42

As can be seen from Table 7, Pseudonocardia autotrophica polyene biosynthetic gene group of the present invention shows a significant similarity to the nystatin biosynthetic PKS gene (Fig. 1), the arrangement of these genes also has high similarity It can be confirmed (Fig. 2).

Example 5 Function of Genes Involved in Pseudonocardia autotrophica Polyene Biosynthesis

Since KR12 and KR13 of the KR domain of the modular PKS (polyketide synthase) are inactive, the polyene of the present invention has a structural difference from nystatin. The gene encoding the amino acid sequence of SEQ ID NO: 7 was cppJ, which was analyzed as a very large gene encoding a protein of 5425aa with three modules. All AT domains of cppJ were found to contain acetate-specific AT (FIG. 3). Comparing the conserved motif of the DH domain of cppJ confirmed that DH15 is active, and in the case of DH17, the conserved histidine residue is changed to proline, indicating that it is inactive DH. 3). cppK is the last 18th module of the modular polyketide synthase (PKS), with one DH present, and in the case of DH 18, the conserved histidine residue at the active site, HXXXGXXXXP, is changed to glutamic acid. At the end, there is a thioesterase gene that cyclizes the backbone portion of the polyene. 4 is a diagram illustrating the analysis of the PKS sequence.

cppDI, cppDII, and cppDIII are genes encoding mycosamine, a sugar part of polyene, and the sugar part of polyene is known to play an important role in antifungal activity. Among them, the cppDI gene encodes 489aa long UDP-glycosyltransferase, and its protein is known to attach the generated mycosamine to the polyene backbone. The cppDII gene encodes a 352aa long aminotransferase and is known to play an important role in producing mycosamine. Finally, the cppDIII gene encodes 344aa long GDP-mannose-4,6-dehydratases, which are known to play an important role in producing mycosamine. . These three genes will be involved in binding mycosamine to the backbone of the polyene.

In the present invention, cppL was found to be a gene encoding cytochrome P-450 monooxygenase, which appears to hydroxylate carbon 10 of CPP. cppN, like cppL, has also been identified as a gene encoding cytochrome P-450 monooxygenase, which appears to hydroxylate carbon number 16 in CPP.

The cppH and cppG genes were analyzed to encode ABC transporters, and these proteins are expected to release CPP out of the cell, and the cppF gene is a 4-phosphopantheteine transferase (4-Phosphopantheteine transferases). ), The protein appears to be responsible for Post translational PKS modification.

cppE, located downstream of cppC, encodes a thioesterase and shows very high similarity (69% identity) to nysE of nystatin. The thioesterase is an extension unit in the chain elongation process of polyketide, unlike thioesterase which is located at the carboxyl end of PKS. Known as 'Proof-reading' (Reynolds, K. A et al., J. Biol. Chem , 277 (50): 48028-48034, 2002).

Sequence analysis of cppO located downstream of cppRIII shows a very high similarity (77% identity) with orf1 encoding putative acyl CoA decarboxylase and upstream of fredericamycin, and also ghrG (73 % identity) and jadN (72% identity) also show very high similarity. The genes of this family are similar to the transcarboxylase involved in malonyl CoA biosynthesis and are known to positively affect jadomycin productivity (Vining, L. C et al, Microbiology, 146). (4): 903-910 2000).

cppM was upstream of cppRIV and showed 35% identity to the N-terminal portion of 4Fe-4S ferredoxin in Kineococus radiotolerans SRS30216. No other genes were found. Generally, the polyene compound has a ferredoxin gene, but the sequence analysis of the Pseudonocardia autotrophica polyene biosynthesis gene group of the present invention shows that cppM is a common polyene ferredoxin (ferredoxin). It was confirmed that there is almost no similarity to the ferredoxin gene in actinomycetes, including the gene), and the poly-10 biosynthesis process of the C-10 moiety by nysN in the process of polyene biosynthesis under the influence of ferredoxin. The carboxylation step in which the group is converted to COOH is unlikely to occur during the post-PKS modification process (FIG. 5).

As a result, due to the difference in the structure of the ferredoxin of the Pseudonocardia autotrophica polyene of the present invention, there is a difference in the overall polyene structure with conventional polyenes such as Nystatin. The polyene antifungal substance shows a large difference in activity and toxicity even with a small structural difference.In the case of amphotericin, the analogue in which the carboxyl group of the polyene is substituted with the methyl group is reduced by about 33 times compared to the conventional amphotericin. (Caffrey, P. et. Al., J Biol Chem , 280 (41): 34420-34426 2005), because the ferredoxin according to the present invention will not play a role in the polyene biosynthesis process of the present invention The new polyene is expected to have an advantageous structure compared to the conventional polyene antifungal material used in the existing industry (Fig. 7).

In silico analysis showed that the polyene biosynthesis regulatory genes all had a structure very similar to that of nystatin and amphotericin biosynthesis regulatory genes. In the present invention, the genes encoding the transcriptional regulatory proteins, cppRI, cppRII, cppRIII, cppRIV, cppRV and cppRVI. cppRI, cppRII, and cppRIII are located downstream of cppE encoding thioesterase, and sequencing results show that transcription of a number of large ATP-binding regulators of the LuxR (LAL) family, including nysRⅠ, nysRII, nysRIII It has been confirmed that it has high homology with transcriptional activator. Analysis of the expected structures of the cppRI, cppRII, and cppRIII polypeptides revealed that they all had LuxR type HTH DNA binding motifs in the C-terminal region, while cppRI and cppRIII had Walker A and Walker in the N-terminal region. It has a B NTP binding motif (FIG. 6A).

cppRIV is located upstream of cppO and has similarity (45% identity) with nysRIV. As a result of sequencing, it was confirmed that there is a PAS-like domain in the N-terminal portion of CppRIV and that an HTH motif of LuxR type exists in the C terminal portion (FIG. 6A). In addition, cppRV and cppRIV present in the upstream portion of cppM encoding the ferredoxin gene also include LuxR type HTH motif in the C-terminal region, and CppRV in the N-terminal region, Walker A and It was confirmed that it has Walker B NTP binding motif. (Figure 6A)

As a result of the sequencing analysis, it was confirmed that the transcriptional regulatory proteins cppRI, cppRII, cppRIII and cppRIV were very similar to nystatin biosynthetic regulatory proteins NysRI, NysRII, NysRIII and NysRIV, respectively (Fig. 6B), NysRI, NysRII, NysRIII and Both NysRIV are known to act as transcriptional activators for nystatin biosynthesis (Zotchev, S. B et al, J Bacteriol , 186, 1345-1354, 2004), CppRI, CppRII, CppRIII and cppRIV also appear to act as transcriptional activators in the polyene biosynthesis of the present invention.

1 and 2 show genes, functions, and gene sequences of Pseudonocardia autotrophica polyene biosynthetic gene group, respectively, FIG. 3 is a comparative analysis of active domains of PKS, and FIG. The sequence of the PKS moiety is analyzed to plot the composition of the PKS of polyene.

Figure 5 is a lineage analysis of several ferredoxin genes in actinomycetes, Figure 6A shows the arrangement of regulatory genes in Pseudonocardia autotrophica , B is cppRI, cppRII, cppRIII, The results of structural prediction analysis of cppRIV, cppRV and cppRVI proteins are shown.

Figure 7 shows the structure of the polyene produced based on the sequence of Pseudonocardia autotrophica polyene biosynthesis gene group.

                         SEQUENCE LISTING <110> INHA-INDUSTRY PARTNERSHIP INSTITUTE        HANSON BIOTECH CO., LTD.   <120> Novel polyene gene cluster from Pseudonocardia autotrophica <130> inha1.25p <160> 26 <170> PatentIn version 3.2 <210> 1 <211> 125717 <212> DNA <213> Pseudonocardia autotrophica <400> 1 tcacgccgcc ggtggcggcg gcagatgcac cgcggtgacg agcaggcccc ggtcggcgtg 60 ccagcgcccg gggaacaccg gcacgctccg tccgccgacg accgggccgg ggacgagcag 120 acgggcggag aacgtgccgg ccgcggcgtc gaacgcgatc tcggcctcgt cgaagtccag 180 ctcgcgaccg gtcaacgggt accaggcctt gaagacgctc tccttggcgc tgaagtacat 240 ccggtcccac gcgatgtccg gccgccgccg tcccagcccg gcgagcagcg cccgctcgga 300 gggcagggtg acggtctcca ggaccccggc gggcagcggt gcgtccggct cggcgtcgat 360 gctcaccgcg gcggactcgg cgaccgagga caccgcggcc gcccggtacc cggtgcagtg 420 cgtcatgctg ccgaccaccc caggcggcca ctgcggggct ccgcgacggt tcgggaggat 480 cggggcgggg gagcggccga gccggcccag cgcgcggcgg gcgagcctgc gcaccgtggt 540 gaactcgcgc cgccgggact ccacggcccg ggcgacgagc tcgcgctcct gggggaagag 600 gccctcgccg gggtgctcct cgtcgtcgta ggcgcactcg gtgacgaccc ggccgggcag 660 cacgtgctcg atcaccgcac acccccggcg accggcagcg gcagcaccgc gcgcaacggt 720 tcccggggcg gccggggccg ccattcgcgc ggatagccca ccgacacctc ctcgaaacgg 780 accccgtcgt agtaggtgac gcgggggatg tgcaggtggc cgtagacgac ggccgcggcg 840 cggaaccgga cgtgccagtc ggccgtcagc tcggtgccgc accactgcgc gaactccggg 900 taccgcagca cccgcgtcgg atgacgcagc agcggccagt ggttcaccag caccgtcggc 960 aggtccgggt cgaccgcggc caggcggtgc tcggtcagcg cggcccggcg tcggcaccag 1020 gtggcgcggt ccgggtaggg gtcgggatgc agcaggaact cgtcggaaca gacgacaccc 1080 gcgtcgtgag cgatccggag cgactccgcc gccgtcgtcg cgccgggggc gcggaaggag 1140 tagtcgtagc cgacgaacag cggggcgacg gcgaccggtc cgccgggacc gtcccacacc 1200 gggtacgggt cctccggagt ggtgacgccc agctcccggc aggtctcgac gagcgcccgg 1260 tagcgcgcgt cgccgcgcag cgtgcagggg tcctgcggat gggtccacag gtcgtggttg 1320 cccggggtcc agagcacgcg tgcgaagcgg ctcgcgagca gacgcagggt cgactcgatg 1380 tcggcgtaca tctcgccgac gtcaccggcg acgatcagcc agtcgcgctc ggtggacggg 1440 cgcagcgact cgacgagcgc ccggttctcg gcgtgcacga cgtggaggtc ggcgacggcg 1500 agcagctggg gttcgggcac ggtgggtcct cccggtcggt cggggaacgg tcagggggcc 1560 agggtgtcgg cgtcgctggt acgcgcggcg tgcagccggg cgtaggcgcc accggcgcgc 1620 agcagtgtgt cgtgggtgcc ctgctcgacg atccggccgg cgtccatgac cacgatccgg 1680 tcggcgtcgc ggatcgtcga cagccggtgc gcgatcacga agctggtccg cccggtccgc 1740 acggtggcca tcgcgcgctg gatcagcagc tcggtgcggg tgtcgacgga gctggtggcc 1800 tcgtcgagga cgagcacggc ggggtcggcg aggaacgccc gcgccaccgt gatcagctgc 1860 ttctgtccgg cgctggcgcc gccggagtcc tcgtcgagga cggtgtcgta gccgtcgggc 1920 agcgtcgcga cgaacgtgtc gacgcaggtg gcgcgggccg cctgctcgat ctcgtcgctg 1980 gtcgcgccgg gcgcgccgta ggcgatgttc tcggcgatgg tcccgccgaa cagccaggtg 2040 tcctgcagga cgagcccgaa ccgggaccgc aggtcggcgc gggtcatcgt cgcggtgtcc 2100 acgccgtcga gcaggatctg cccgccctcg atctcgtaga agcgcacgag gaggttgccc 2160 agggtggtct tccccgcgcc ggtggatccg acgatcgcga ccgtgctgcc cggctccacg 2220 gtcagcgaca ggtcctcgat gagcgggacg tcggggacgt agcggaacga cacccggcgg 2280 aactcgaccc ggcccgccgg tgccgcgggc acggcagggc gggccggctc gggcgactgt 2340 tcgggcgcgt cgagcagcgt gaacacccgc ttcgccgaca ccacccccga ctggagccgc 2400 ccggccaccg aggcgatctc gacgatcggc tggctgaact ggcgggcgta gaggatgaac 2460 gcctgcacgt cgccgagggt gagcgagccg gagagcacct tccacgcgcc gaggacggcc 2520 accaccaggt acccgaggtt cgccacgaac atcatcaccg gctccatcgc gccggacgag 2580 gtctgggccg acgccccggc ccggtacacc gcgtcgttgc actcggcgaa ccggcgccgc 2640 gcctcgtccc ggcggtggtg gccgcggatg agggagtgcc cggtgcagac ctcctcgacg 2700 tgggcgttga gcgcgccgtt ggcctcccac tgtgtggtga actgcgggtg cgcgtggcga 2760 cccagcccga ccgcgagcag ccccgccagc ggcacgctga ggatcatcac catcgccagc 2820 gacggcgaga tcaccaccat cagcgtgagc atcgcgacca gcgacaggag cgaggtgatc 2880 agctcggcca gggtctgttg gagggtctgc tggaggttgt cgacgtcggt ggtggtacgt 2940 ccgagggtct cgccggccgc atgccggtcg tagtgccgca gcgggaggcg ggacagtttc 3000 gcccgggccc ggccccgcag gtcgtggatc acctgccaca ccacggatgc gacgatccgg 3060 ccctggacga gcgtgaacag cgacgccccc aggtagacca cgagcaggac cagcagcaac 3120 ctggcgaccg agtcgaagtc gacaccgtcg gcggggccgg ggctgcccgc tgcgggcccg 3180 cccgctccgc ccggacccag gacgccgacc gcgatcaggt cggtcacccg gcccagtagc 3240 agcgggccga cggcgttgag cgcgatcccg gccacgccgg tcaggacggc cagcgccacc 3300 ggcccgcggt gcggccgcag cagccccacg agccggcgcg ccgggcggtc acccggcgcg 3360 ggtccgtcgg gtggtcccgc cgggccctcc cccggccggg tggccgccga cggggcgggc 3420 tcagtgacgt ccggcgaggc catgggcgac gtcctcctcg gtgggctggg agttcgcgat 3480 ctcgcggtag gtcgggctgt cgcgcaggac gtcgtcgtgg gtaccgtcgg cgaccagccg 3540 tccggcgtcg aggacgacga cccggtcggc gtcgcgcgcg gtggcgaccc gctgggtcac 3600 ggtgatcacg gtggcgcctg cggtccacgg ggccagcgcc gcccgcagtg cggcgtcggt 3660 ggcctggtcc aacgcggaga agcagtcgtc gaacaggtag atctcgggcc ggcggaccag 3720 ggtgcgggcg atgcacagcc gctggcgctg gccaccggac acggtggtgc cgccctgcgc 3780 gatctccgcg tccagaccgc ccggcatccg cgcgacgaag ccgtcggcct gcgcgacgcg 3840 caatgcctcc cagagctcgt cgtcggtcgc gtccgtccgc ccgaaccgca gattgctcgc 3900 gaccgtgccg gcgaacaggt aggggcgctg cggcacgaac ccgacgacgc cggtgagcac 3960 cgcggggtcg agccgtcgca cgtcggtgcc acccacccgg accgtgcccg cggtcggatc 4020 gaccagccgc agcacgaggt tcagcagggt cgacttgccg ctcccggtgc cgcccagcac 4080 cgcgagccgc tcgcccggct cgacgaccag gtcgaccccg cgcagcaccg cacgctccgc 4140 gcccgggtag cggaactcgg cgtcccggat ctcgacccgt cccgcggggc cgtggagcgg 4200 agccggggtc gccggtgcgg ccacggccgg ctcggtgtcg agcacctcca ggatccggcc 4260 cgcccccacc cgggcccgcg gcacctgcag gaacacgaac gcgagcatca cgaccgacat 4320 gagaatcaac gacaggtaga acaggaatgc gctgagcgcg cccagctgca tcacgcctgc 4380 gtcgatgcgg tgggcgccga gccacatcag gacgaccgtg aacacgttca tcatcagcag 4440 caccagcggc agcatcgtgg cgatcagccg gccgacctgc cgggagaggt cgaggaacgc 4500 gtcgttgctg cgggtgaagc gcacctgctc gtggtcctca cggacgaacg agcggaccac 4560 ccgcaccccc gtgatcgact cccggagcag ccgtccgagg tcgtcgaggg cgagctgcat 4620 ccggccgtag aggccaccca tccggaccag cagcagaccg aaggccaccc cgacgaccag 4680 cacgaggacg accagcagca gtgccagcgg tacgtcctgc gccagcgcga gcacgatgct 4740 gccgatgcac atcagggggg cggacacgac gacaccgaac ccggaacggg cgaggttctg 4800 cacctgttgg acgtcgttga ccgtgcgggt cagcagcgac gccgtcccga acctgccgat 4860 ctcgcgggcg gagaagtcca ggatgcggtc gaacaccgcg gcgcgcaggt cccggcccac 4920 cgcggtggag gtgcgtgccc ccagggcggt cgccgccagc gccgccgcga tctggaccac 4980 ggcggtgccg gccatcagca ccccgagctc ggcgatccgg ccggggtcgg cgcggaccac 5040 accctcgtcg atgagggccg cgccgagcgt cggcagcagc agcgttccgg cgatctgcgc 5100 ggtctggagg acgacgaggg cgcccgccgg cccggcgtag ccgcgcagcc gggtgcgcgc 5160 gagtctccac agcacgtcag gacacccccg gttcacggcg accgccgggc cgcccggtgg 5220 acgatgccgg tggcacaccg gccaggacag ccgaccagac cgcggacccg gaatccccca 5280 gttctgctca ccatttcctg cggccgcact cgtgaattcc ctacatcccg gcggattcgt 5340 tgacaccgtc tcgccgatct tgccagcgtg cggcgtgtct ctcgtccgga cagcgtattc 5400 gccgccgtgc cgacggccgg tcgacgcgta tgggcgggcc cggtaacggt cgaaagggaa 5460 tcccgatgtc caaacgcgca ctgatcaccg gaatcaccgg tcaggacggc tcctacctgg 5520 cggagcacct gctgtcgcag ggctaccagg tctggggcct gatccggggg caggccaacc 5580 cccgcaagac gcgggtcagc cggctggcgt ccgagctgga gttcgtcgac ggcgacctga 5640 tggaccaggc cagcctggtc tcggccgtcg acacggtgca gcccgacgag gtctacaacc 5700 tcggcgcgat ctcgttcgtc ccgatgtcct ggcagcaggc cgagctcgtc accgaggtca 5760 acggcaccgg tgtgctccgg gtgctcgagg cgatccggat ggtctccggc ctctcgatgt 5820 cgcgcacggc gtcgccgaac gggcagatcc gcttctacca ggcctcgtcg tcggagatgt 5880 tcggcaaggc cgcggagacc ccgcagcggg agacgacgct gttccacccg cgcagcccct 5940 acggcgccgc caaggcctac ggccactaca tcacccgcaa ctaccgcgag tcgttcggca 6000 tgtacgcggt gtcgggcatg ctgttcaacc acgagtcgcc gcgccgtggc caggagttcg 6060 tcacccggaa gatctccctg gcggtcgccc ggatcaagct cggcctgcag cgcgacctcg 6120 cgctgggcaa cctcgacgcg gtgcgcgact ggggctacgc gggtgactac gtccgcgcga 6180 tgcacctcat gctgcagcag ggcgagcccg acgactacgt gatcggcacc ggccagatgc 6240 actcggtgcg ggacgcggtg cagatcgctt tcgagcacgt ggggctggac tggcgggaca 6300 aggtcgtcat cgacccggcg ctggtgcgcc cggccgaggt cgaggtgctg tgcgccgaca 6360 gcctgcgggc ccggcggctg ctcgactgga cgcccgaggt cgacttcccc gagctcatgc 6420 ggatgatggt cgactccgac ctcgagcacg tggcgcggga gaacgagtac ggccacctgc 6480 tgctggccgc caactggtga accggcggac gacacactag ggatttccgg cccggatcct 6540 ccgcagaatc atctgcgatg agcccctccg ccgtacggcg ggaacggggc ggcgattcgg 6600 ttcctgtcgg atgtgtgcgg aattccggcg cgattgtcag cgggcgtcgg cggcgagacg 6660 ggtggagttg gaatggacaa cgaacagaag ctccgggact acctcaagct ggccacggcc 6720 gacctgcgcc gtacccgccg gcgggtgagc gagctcgagt ccgccgccca ggagccgatc 6780 gccgtcgtcg ggatggcctg ccgctatccc ggcggtgtcc gcagcccgga ggacctgtgg 6840 cggatggtcg aggcggggga ggacggcgtc acgccgttcc ccaccgaccg cggctgggac 6900 accgccgcgt tcgccggctc cccgacgaga tccggcgggt tcctgcacga cgcccccgac 6960 ttcgacgccg agttcttcgg catctccccg cgcgaggccg tcgcgatgga cccgcagcag 7020 cgggtcgtcc tggagtccgc ctgggaggcg ttcgagcggt ccgggatcga cccggtctcg 7080 ctgcagggca cccgcaccgg tgtgttcgtc ggcgcgatgg cgcaggacta ccgggtcggc 7140 ccggcggacg gcgccgaggg tttccagctc accggcaaca ccggcagcgt cctatcgggg 7200 cgcatctcct acaccttcgg cacggtcggc cccgccgtta cggtcgacac cgcgtgctcg 7260 tcgtcgctgg tggcggtgca cctcgccacc caggccctgc ggggcggtga gtgctcgctg 7320 gcactggccg gcggtgtcac cgtgatgtcc gggcccggca ccttcatcga gatgggccgc 7380 cagggaggac tgtccgccga cggccgctgc cgatccttcg gcgacacggc cgacggaacc 7440 ggctgggccg agggcgtcgg cctgctcgtc ctggagcggc tgtccgacgc gcgccgcaac 7500 gggcacgagg tgctggccgt cgtccgcggc tccgcggtca accaggacgg cgcgtccaac 7560 gggctcaccg ccccgaacgg cccgtcccag cagcaggtca tcgaacaggc gctggtcaac 7620 gcccggctgt cggctggcga cgtcgacgtc gtcgaggcgc acggcaccgg aaccaccctc 7680 ggcgacccgg tcgaggcgca ggcgctgctg gccacctacg gacgggaccg ggacgtcgag 7740 cgcccgctgc tgctcggctc ggtcaagtcg aacatcagcc acacccaggc cgccgccggc 7800 gtcgccgggg tgatcaagat ggtgatggcg atgcggcacg gggtactgcc ccgcacgctg 7860 ctcgccgagg accccagccg gcacgtcgac tggtccccgg acaccgtccg catcctcacc 7920 gagaacaccg actggccggc caccggagcc ccgcgccgcg ccgcggtctc ctcgttcggg 7980 atcagcggca ccaacgccca caccatcatc gagcaggccc ccgcccccga gaccggtacc 8040 cctgcccccg aggacgacgg cccggccgtc ggcgagcccg gcccgaccga gcccggcacc 8100 gtcccggtcc tgctctccgg gcgcaccccc gaggcgctgc aggcccaggc cgccgcgctc 8160 ggcgaggcac tcgccgccgc ccccgacacc ccgctgaccg acgtcgcgtg gtcgctggcc 8220 acaacccgga ccgcgttcgc ccaccgcgcc gtgctgctcg ccgccgaccg cgacgccctc 8280 gccggtggtc tcgacgcgct ggccgcgggc gatcccgccg cggccggtga cacggtgacc 8340 gccgaggccc ggccggacag ccggctcgcc gtgctgttca ccgggcaggg ctcgcagcgg 8400 atcggcgccg ggcgcgagct cgccgcccgc ttcccggtgt tcgccgaggc cctggacacg 8460 gtgctgtccg cgttcgaccc ggagctgcag cgcccgctgc gcgagatcct ccggcgcact 8520 accgacggca ccacccccga cgagaccgcc gccgcgctgc tcgacgacac cgcgtacgcc 8580 cagcccgcga tcttcgccgt cgaggtggcg ctgtaccggc tcgtcacctc cctcggcgtc 8640 accccgggcc acctgctcgg acactcggtc ggcgagatcg ccgccgcaca cgtcgccggg 8700 gtgctcgcgc tcgacgacgc cgccaccctg gtcgccgccc gcggccgcct gatggcggcg 8760 ctgcccaccg gtggcgccat ggtcgcggtg caggccaccg aggccgaggt cgaggccctg 8820 ctcgacgggt accgcgaccg ggtctcggtc gccgcggtca acggcccgtc ggcggtcgtg 8880 ctgtccggcg ccgacgaggc ggtcaccgcc gtcgccggcc tgctcgccga ccagggacgc 8940 cggacccggc ggctgcgggt gagccacgcg ttccactcgc cgctgatgga accgatgctc 9000 gacgagttcc gcgccgtcgt cgagggcctc gacctgcagg caccgctgat cccgatcgtc 9060 tccgacgtga ccggcgagct cgcgaccgtc gcccaactca cctcggccga ctactgggtc 9120 gagcacgtcc gcagcgccgt ccggttcgcc gacggcgtcg actggctcgc ccgccacgac 9180 gtcaccgcgt tcctcgagct cggcccggac ggccccctgt ccgccatgac gcgcgactgc 9240 ctcgacgccg cggaccccgg cgcccccgcc tcggtcgccg tgcccgcgct gcgcgccggg 9300 cgccccgagg agcacaccct caccgccgca ctggccgcgc tgcacaccca cggcaccgcc 9360 gtcgactggg caccctggtt cgccggcacc ggcgcccgcc gcaccgacct gcccacctac 9420 gccttccggc gccgccggtt ctggcccaag gccctccaga ccggtgccgc cgacctgcgc 9480 tcggccgggc tcggcgccgc ccggcatccg ctgctgtcgg ccacggtgtc gctcgccgac 9540 tccgagggcg cgctgctcac cggacggctg tccctgcaga cccacccctg gctcgccgac 9600 cacaccgtgc gcggcaccac cctgctgccc ggcaccgcct tcctggagct ggccgtgcgg 9660 gccggcgacg aggtcggctg cgaccgggtg gaggagctga ccctcgccgc cccgctggcc 9720 ctgcccgacg agggcggggt cgcggtccag ctgtgggtcg gggccccgga cgccggtggc 9780 cgccgcaccc tgaccgtcta cgcccggccg gacaccgacg ccgacgccga gcacgacgtt 9840 ccctggaccc cgcacgccac cggcgtcctc gccgcgggcg gcgccgtccc ggcgaccccg 9900 gacgcgaccg agtggccgcc cgccggggcc gagccgctcg gggtcgagga cctctacgac 9960 cgcctggcgc aggccggctt cggctacggc cccgccttcc gcggcctcac cgcggcctgg 10020 cgccacgacc acgccgtgct cgccgagatc gtgctgcccg aggcaggccg taccgacgtc 10080 gacgccttcg gcctgcaccc cgccgcgctc gacgccgcac tgcacgccgc agggttcgtc 10140 gagctgggcg agcgcagccg cgggggtatg cccttctcct gggagggcgt gacgctgcac 10200 gcgagcggcg cggggaccct gcgggtgcgc ctgaccccgg tcgccgacga cgcgatcgcc 10260 gtcgccgtcg ccgacgggac cggtgcaccg gtcgtcaccg tcgactcgct ggtgctgcgc 10320 ggagtcggcg agctcgacct cgactccgcc ggtgccgtcg cccgggacgc gctgttccgg 10380 ctcgactgga cgcccgtcac ccccgcgggt gaggtccccg gcagcgtcgt gatcgccggc 10440 gacgacgtgc tcgggctcgc cacgcacccc ggcctcggcg ccgcgcacgg cggcgtcgcc 10500 ggaccgacgg acctggcgac gctcgtgacc gcagacggtc ccgcccccga cgtcgtgctg 10560 ctcggcctgg ccgggggagc ggaggccgcg caggcgcacc gctgtgccgc cgacgcgctc 10620 gccgccgtcc gcacctggct cgaccacgcc gaccgcctgg acggctcccg cctggtcgtg 10680 gtgacccggg gcgccaccac cggtgacgac gtggccgccg cggccgcgtg gggcctgctc 10740 cgctccgccc gctcggagaa ccccggccgg ttcgcgctgc tcgacctcgc cccggacgtc 10800 gaccccgccg acctgccgct caccgcgctc acggccgacg agcccgagct gctgctgacc 10860 cgcgacggtc tgcgggcggc ccggctcgtg cgccgccccg ccccgcgcga ggccggcgcc 10920 accccgtcgt tcggggacgg cgccgtgctg gtcaccggcg gcaccggcgg cctgggtgcc 10980 gtcgtcgccc ggcacctggc caccacccac ggcgtgaccg acctgctgct ggtcgggcgc 11040 cgcggcccgg ccgccgacgg cgcggccgag ctggtctccg acctcaccgc cgccggtgcg 11100 cgggcccagg tcgtcgcctg cgacgtgagc gaccccgcgg cggtgaccga gttgctcggc 11160 gcgcaccggg tgacctcggt ggtgcacgcc gccggggtgc tcgacgacgc caccgtcggt 11220 tcgctgaccc cgcagcggct cgcggcggtg ctgcgcccga aggtcgacgc cgcgtggaac 11280 ctgcacaccg cggccgcggc cctgggtctc gacctcgacg cgttcgtgct gttctcctcg 11340 gtcgccgggg tgttcggcag ccccgggcag gcgaactacg cggcgggcaa cgccgccctc 11400 gacgcgctcg ccgcgcaccg tcgggccgcg ggcctggcag gtctgtcgct ggcctgggga 11460 ccgtgggagc ggaccggcgg gatgaccggt ggcgtctccg acgaggacat ggcgcgaatg 11520 gcccgcgccg ggacccccgc cctcaccgtg gagcaggggc tgaccctgtt cgacgccgcg 11580 ctcggcgccc ccgagcccgc cctggtgccg gtccgtctgg acctgcccgc cctgcgggcc 11640 ggcggcgagg tcccgccgct gctccggtcc ctgatccgta cccgggcccg gcgcaccgcg 11700 gccaccggct cggcgacggc gaacggtctc gcccagcggc tggcccgcct ggacgccgag 11760 ggacgcgagg agatggtcct ggacctggtc cgcggccagg tcgccctggt gctcgggcac 11820 gccggtgcgg ccgacgtcga cgccggccgc gcgttccgcg acctcgggtt cgactcgttg 11880 accgccgtcg agctgcgcaa ccggctcggt accgtcaccg ggctgcggct gcccgccaca 11940 ctcgtgttcg accacccgac ggtccggcac ctcgcggccc acgtcaccga cgagctgctg 12000 ggcgccgaga ccgaggccgt cccggccgcc cgcgtcgcgg tggacgtcga ggacccgatc 12060 gtcatcgtcg gcatggcctg ccgctacccg ggcggggtgt ccacgcccga cgagctgtgg 12120 cgcctggtca ccgagggcac cgacgcgatc tccggtttcc cgaccaaccg gaactgggac 12180 ctcgaggcgc tgcaccaccc ggacccggac caccccggca ccacctacac ccgctccggc 12240 gggttcctgc acgaggcggg cgagttcgac ccggccttct tcgggatgag cccgcgcgag 12300 gcgctggcca ccgactcgca gcagcgccag ctgctggaga cctcgtggga ggccgtcgag 12360 cgggcgggca tcgacccgtc gacgctgcgc ggcaccgcga ccggcgtgtt cgccggtgtc 12420 atgtacagcg actacaacgc cgtcctggcc ggggggcccg agttcgaggg cttccagggg 12 480 gtcggcagct cgccgagcct ggcctcgggc cgggtcgcct acaccctcgg gctggagggg 12540 cccgcggtca ccgtcgacac cgcgtgctcg tcctcgctgg tcgcgatgca ctgggcgatg 12600 caggcgctgc ggaccgggga gtgctcgctc gcgctggccg gcggtgtcac cgtcatgtcc 12660 accccggcgg cgttcgtcga cttcgcccgc cagcgcggcc tgtccccgga cgggcgctgc 12720 aaggccttct ccgacgacgc cgacggcgtc ggctggtccg agggcgtcgg catgctggtg 12780 ctggaacggc agtccgacgc gctgcgccac ggccacgaca tcctggccgt ggtccgcggg 12840 tccgcggtca actccgacgg cgcctccaac gggatcaccg ccccgaacgg gccgtcccag 12900 cagcgggtga tccgccaggc gctggcgagc gcggggctgt ccaccgacga cgtcgacgtc 12960 gtcgaggcgc acggcaccgg cacctcgctg ggcgacccga tcgaggccca ggcgctgctg 13020 gccacctacg gccgggaccg ggacaccgac cggccgctgc acctggggtc gctgaagtcc 13080 aacatcgggc acacccaggc cgccgccggc gtcgccggcg tgatcaagat ggtgctggcg 13140 atgcggcacg gcgtgctgcc ccgcacgctg cacgcggaca cccgttcctc gcacgtggac 13200 tggaccgagg gcgccgtgga gctgctcacc gagcagaccg cgtggccgga gaccggccgt 13260 ccgcgccggg ccgcggtgtc gtcgttcggg atcagcggca ccaacgtgca cacggtgctg 13320 gagcagggac cggactccgc gcccgccccc gaccccggtc ccggggccac cccggccgtg 13380 gtcccgctgc tgctctcggg ccgcggccgc cccgcgctgc gcgcccaggc cggccggctg 13440 ctcgaccacc tgcgggacca cccgggcgtc cgcacggccg acctcgccca ctcactcgcc 13500 accacccgca cccgcttcga ccagcgcgcc gccgtgctgg cgggtgaccg cgaggacctg 13560 ctcgccgcgc tcggcgcgct cgccgccgga cgtccggacc cgcgcgtcgt ggagggggag 13620 gccgccgggc gtgcccggac cgcggtgctg ttcaccggcc agggcagcca gcgcgccgcg 13680 atgggccgcg agctgtacgc cgcccagccg gtgttcgccg ccgcgttcga cgaggtctgc 13740 gccgcgctgg acccgctgct cgagcggccg ctcgccgagg tcgtgttcgc cgaggggggc 13800 accgcggagg ccgcgctgct cgacgagacc ggctggaccc agcccgcgct gttcgcggtc 13860 gaggtcgcgc tgtaccggct cgtcgagagc tggggcgtgc gggccgacct cgtggccggg 13920 cactcgatcg gcgagatcac cgccgcgtac gtcgccgggg tgttcaccct ggccgacgcc 13980 gcccggctgg tcgccgcccg cgcacggctc atgcaggcgc tgcccaccgg tggcgccatg 14040 gtcgcgatcg cggccggcga ggacgaggtc accccgctgc tcgacgagcg ggtgtcgatc 14100 gcggcggtga acgcgccggg atcggtggtc gtctccggcg acgccgacgc caccgccgcg 14160 ctcgccgcga cgttcgccga gcagggccgc cggacccgca cactgcgggt cagccacgcg 14220 ttccactcgc cgcacatgga cggcatgctc gaggacttcc gggccgtggc cgagcggatc 14280 gagtaccacg cgccccggat cccggtggtc tccaacctca ccggcgcccg ggccgccgac 14340 accgagctgt gcgagcccgg gtactgggtg cggcacgtgc gcgaggcggt ccggttcgcc 14400 gactgcgtca ccacgctgca cgaccagggc gcgaccgtcc ttctggagct gggacccgac 14460 gcaccgctca ccgcgatggc ccgcgagacc ctcggggacg gcgccgacac cgcgctggtg 14520 cccttcctgc gcgccgaccg gggcgaggag ctcgccgccg cgacggccgc cgcccggctg 14580 caggtccacg gcctggacct cgaccccgcc gcgctgctgc acgggaccgg tgcccgccgc 14640 accgccctgc cgacctacgc cttccagcac gagttctact ggccgcagct gcccgcggcc 14700 gccgcgtccg ccggggagga caccgacccg gccgaccggc agctctgggc cgccgtcgag 14760 cgcggggacg ccgccgagct cgccggcatc ctcggcctcg acgccgacga cgtcgccacc 14820 ccgctgctgc ccgcactgac cacgtggcgg cgcggcaacc gggagaaggc ccggctcgac 14880 accctgcgct accgcgtcga gtggacccgg ctgcggcgcc ccgccgcgcc ggtcctcgac 14940 ggcacctggc tgctggtcgc caccggcgcc accaccgacg ccgagaccac gctgctcgac 15000 gggctcgccg acaccctcgg cgcgcacggc gcccgggtcc gccggctcgt cctcgacgac 15060 gactgcccgg ccgaccgcgc cgcggtcgcc gcgcggctgg ccgcgggcac cgccgacggt 15 120 gaccccgccc acgtgctgtc cctgctgccg ctcgacgagc gccccgctgc gggcgccgcc 15180 ccgctgaccc gcggcctcgc cctgaccgtc gcgctcgtcc aggccctcgc cgacgccgac 15240 gccggtgaca gcaccgggac gaccgcacgg ctgtggaccg cgacccgcgg cgccgtctcc 15300 accggtcccg ccgacccggt cacccacccg gtgcaggcca ccgcatgggg cctgggccgc 15360 agcgtcgctc tggagcaccc gcggctgtgg ggcggcctgg tcgacctccc ggccgagctg 15420 gacccgcgca gcgcccagcg cctcgcgggg gtgctcgccg acaaggacac cccggacggg 15480 gaggaccagg tcgcgttgcg cgccgccggt gtgtccgggc gccggctcgt ccggcacacc 15540 gtcgacgcgc tgccgcccgc caccgcgttc accgcgaccg gctcggtcct ggtcaccggt 15600 ggtaccggtg ggctcggcgc cgaggtcgcc cgatggctgg cccgctccgg cgtggcccac 15660 ctggtgctca ccagccgtcg tggccccgac gcacccgggg ccgccgagct gcgcgacgag 15720 ctcaccgcgc tgggcgcctc ggtcgcgatc gaggcctgcg acgtgaccga ccgcgacgcg 15780 ctcgccgccg tgctggacgc cgtacccgcc gacgcgccgc tgaccggcgt cgtgcacacc 15840 gcgggcgtcg gccactacga cgcgctcgac accctcgacg tcgagggtgt cgccgcccgc 15900 acggccgcca agatcgccgg cgccgcgcac ctcgacgacc tgctggccga ccgcgagctc 15960 gacctgttcg tgctgttcgg ctccgtcgcc ggggtgtggg ggagcggcgg gcagagcgcc 16020 tacggcgccg ccaacgccta cctcgacgca ctcgccgcgc accgccgcgc ccgcggcgcc 16080 accgccacca gcatcgcctg gggcccgtgg gccgggtccg gcatggccac cgaggagtcc 16140 gtggccacga ccctgcagcg gcagggactc ggcctgctcg accccggccc ggccatgacc 16200 gagctgcggc gcgccgtcgt cgacgccgac acccaggtca ccgtcgccga cgtcgactgg 16260 gaccgctacg caccgctgtt cacctcggcc cggccgagcg cactgatcgc cggtctcgcg 16320 gacctcgcgg agccggagtc cggcgtcgcc gccaccgaga tcgtcacccg ggtccgcgcc 16380 ctcgacgagc ccgccgggat gcgcctgctc accgagctgg tccgcggtgc ggccgcggcc 16440 gtgctgggcc acgggtcggc cgagtccgtc gccgggtcgc gcgcgttccg cgacctcggg 16500 ttcgactcgc tgaccggggt cgagctgcgc agccgtctcg ccgccgcgac cggcctgacg 16560 ctgcccagca cgctggtgtt cgaccacccg agcccgctgg agctcgcccg gcacctgcgt 16620 gccgagatcc tcggcaccgc ggcggagggc accggcccgg tcgccgtcgg cgccgccgac 16680 gccgagccga tcgcgatcat cggcatggcc tgccggttcc ccggcggcgt ctcctcgccg 16740 gaggcgctct gggacctggt cacctccggt accgacgcga tctccgactt cccggtcaac 16800 cgtggctggg acaccgccgc gctgttcgac cgcgacccgg accgccccgg gaccacctac 16860 tccacccagg gcgggttcct gcacaccgcc gacgagttcg acccgtcgtt cttcggcatc 16920 tcgccgcgcg aggcgctggt gatggatccg cagcagcggc tgctgctgga gaccacctgg 16980 gagtccttcg agcgggccgg gatccgtccc gacaccgtgc gcggcagcct gaccggcacc 17040 ttcatcgggt ccagctacca ggagtacggc ctgggtgccg gtgacggcgc cgagggtcac 17100 ctggtcaccg gcaccagccc cagcgtgctg tccggcaggt tgtcctacgt gttcgggctg 17160 gagggcccgg ccgtcaccgt cgacacggcg tgctcgtcgt cgctggtggc actgcacctg 17220 gcctgccagt cgctgcgcaa cggggagagc accctcgggg tcgccggcgg cgccaccgtc 17280 atgaccaccc ccaacccgtt catcgcgttc agccgccagc gcgcgctggc ccgcgacggc 17340 cgctgcaagg ccttctccga cgacgccgac ggcatgaccc tcgccgaggg cgtgggcatc 17400 gtgctggtcg aacgcctctc cgacgccgag cgccacggcc acccggtcct cgcggtgatc 17460 cgcggctccg ccatcaacca ggacggcgcc tccaacggcc tgaccgcccc gaacgggccc 17520 tcccagcagc gggtcatccg ccaggcactg gccaacgccg ggctcgagcc cggcgacgtc 17580 gacgccgtcg aggcgcacgg caccggcacc ccgctgggcg acccgatcga ggcccaggcc 17640 ctgcagacca cctacggccg cgaccgcgac gcggcgcgcg cgctgctgct gggctcggtg 17700 aagtccaaca tcgggcacac ccagtccgcc gcgggcgtcg cctcggtgat caagacggtg 17760 atggcgctgc ggcacggggt gctgccccgc acgctgcacg ccgacgagcc gtcctcgcac 17820 gtggactggt cggcaggcag cgtcgagctg ctcgccgagc agaccgcatg gccggagacc 17880 ggtcgtcccc gccgggccgc ggtgtcgtcg ttcgggatca gcggcaccaa cgcccacacc 17940 gtgctggagc aggcgcccga ggccgccccg gtggcccccg cgaccccgtc ggggcccgtc 18000 ctgccgtcgg cgccggagcc ggtcctgccg tgggtgctcg gcgcccgcgg tgccgccgcg 18060 ctgcgcggcc aggccgaccg cctgctcgcc cacctcgaga cgaccgacgc ccgccccgcc 18120 gacatcgggt tctccctggt gagtgcgcgg atgccgttcg agcaccgcgc cgtcgtcgtc 18180 gcgaccgacc ccgcggaccg ggcggccggg ctgcgcgcgg tcgccgccga cggcccgtcc 18240 ggcgtcgtcg cccgcggtgt cgccgacgtc gagggccgca ccgtgttcgt cttccccggt 18300 cagggatcgc agtggctcgg gatgggcgca cgcctgctcg aggagtcccc ggtgttcgcc 18360 gaccgggtcg ccgagtgcgc cgaggccctc gccgagttca ccgactggtc gctcgacgac 18420 gtgctccgcg gcgccgaggg ggcgccgccc gtcgagcggg tcgacgtcgt ccagcccgcc 18 480 accttcgccg tcatggtcgg actggccgcg ctgtggcgcg cgcacggcgt cgagcccgac 18540 gcggtcgtcg gccactccca gggcgagatc gccgccgccg tcgtctccgg tgcgctgtcg 18600 ctgcgcgacg gtgcccgggt ggtcgcgctg cgcagccggg cgatcgcgcg gtcgctggcc 18660 gggcgcggcg gcatgatgtc ggtcgcgctg ccggtcgccg acgccgaggg gcacctcgcc 18720 ggctacgagg gccgggtgtc ggtggccgcc gtcaacggcc cccgttccgc ggtgctcgcc 18780 ggcgagcccg acgcgctcga cgagctgctc gccgcgttcg acgccgccga tgtccgcgcc 18840 cgccggatcg cggtggacta cgcctcgcac tcgcaccagg tcgaggacct gcgcgacgag 18900 ctcgccacga ccctcgccgg gctcgccccg cagccgtcgc aggtgccggt gttctccacg 18960 gtcacgggcg actggctcga cacgaccacg atggacgcct cctactggta cgagaacctg 19020 cgcaaccggg tccggttcgc cgacgcggtc gaggccctgc aggccgccga gtaccgcacg 19080 ttcgtcgaaa cgagcccgca cccggtgctg tcgatgtcgg tgcaggacgt gctcgacgac 19140 gccggcgtcg ccggtgtcgc gggtggcacg ctgcgccgtg accagggcgg ctacgaccgg 19200 ttcgtgctgt ccgcggcgga gctctacgtc cggggggcgg ccgtcgactg gacccgggtc 19260 ttcgacggga ccggcgcgtc ccgcaccgac ctgcccacgt atgcgttcgc ccacgaccag 19320 ctgtgggtcc tgccccccgc ggtcaccgcc gccgccgacc cgcaggacga ggcgttctgg 19380 gccgccgtcg aggacggcga cgtcgccgcc ctgaccagca ccctggacac cgacccggac 19440 gcggtcgccg cggtcctgcc cgcgctggtc agctggcgcc gcggccgccg ggaccgctcc 19500 accctggact cctggcgcta ccgcgtgtcc tggaaaccgg ccgggtcgct gccgcagcgg 19560 agcctggcgg gcacctggct ggtcgtctcg gccgagggga ccgacgacac cgaggtggcc 19620 ggtgcgctgg ccgcgcacgg ggccgacgtg cgccgcgtcg tcctcgacga gacctgcacc 19680 gaccgcgccg tcctggccgg gcggctcgcc gcggcgaccg gggacgactc cgccgccgac 19740 ccggccgccg tctcggggat cgtctcggtg ctggccgagg ccgacaccac gaccgtgccg 19800 cggaccggcc tggtcaccgg ggtggcgctg accgtcgcgc tgatccaggc gctgggcgac 19860 agcggcatcg acgcgccgat gtgggcactg agccgtggcg ccgtcgccac cggacgcgcc 19920 gacgaggtca tcgccccggt ccaggcccag gtcctgggca tcggctggac cgcggcgctg 19980 gagcacccgc agcgctgggg cgggacgatc gacctgccgg tcgccctgga cgagcgcggg 20040 gccgcgcggc tggtcgccgt cctcgccggg gagctgggcg ccgaggacca gctcgcgctg 20 100 cgtcccaccg gggtgttcac ccggcggatc gtgcgggccg agcccgcggg cgcccggccg 2016 0 gcccggacgt gggacccgcg ggggaccacg ctggtcaccg gcgggtccgg caccctcgcg 20220 ccgcacctgg cgcgccgcct ggccgagcgg ggcgccgagc acgtcgtgct gctgtcgcgc 20280 cgtggccccg acgcccccgg cgcggccgag ctgctcgccg agttcgacgg cagcgacacc 20340 acggtcgagg ccgtggcctg cgacatcacc gaccgcgccg ccgtcgcggg cctgctggag 20400 cggctcgacg cccacggcgc cacggtgcgc accgtcctgc acaccgccgc caccatcgag 20460 ctcgccaccc tcgacgccac gacccaggag gagctcgccc gggtactgca cgccaaggtc 20520 accggcgcgc aggtgctgac cgagctgctc gacgagcggg gcggcgaccc agccgaggtg 20580 gtcctgttct cctccaccgc gggcatgtgg ggcagcgggg cgcacgccgc ctacgtcgcg 20640 ggcaacgccc acctcgccgc cctcgccgag caccggcggg cccgcggcct gccgaccacg 20700 tcgatcgcct ggggcatctg ggccgacgac ctgaagctcg gccgggtcga cccggccgcc 20760 atccggggca gcggcctggt gttcatggac ccgcagctcg cgctgaacgg gctcgagcgg 20820 gccctcgacg acgccgagac cgtcgtcgcg gtcgccgacg tcgactggga cacctaccac 20880 ccggtctaca cctccggacg gcccacacgg ctctacgacg agatccccga ggtcgtggcg 20940 ctcaccgccg ccgcggaacg gaccgcgggc acggtcgccg cgggcgagtt cgccgccacg 21000 ctggacgggc tgaccgacgc cgaggcgctg cgccgcgtcc tcgacgtggt ccgggccgag 21060 gccgccggcg tgctcgggat ggcctccgcc gacgacctca ccgaccagcg ggcgttccgc 21120 gacgtcgggt tcgactcgct gaccgccgtc gcgctgcgga accggctcgc ctcggtcacc 21180 ggcctgacgc tgccctcgac gatggtcttc gaccacccga cacccgcggc gctcgccgag 21240 ttcctgaggg ccgagctggc cggggccacc ccggtcgcgg ccggcgccgg gtccaccgcg 21300 gccgcccagg accaggacga cccgatcgtc gtcgtcggca tgagctgccg ctaccccggc 21360 ggggtcgcct ccgccgagga cctgtggcgg gtcgccctcg acgaggtgga cgcgatctcc 21420 gggttccccg acgaccgcgg ctgggacgcc gcatcgctct acgacccgga ccccgaccgg 21480 gccgggcaca cctactcgac gcagggcggg ttcctgcgcg acgtcgccga cttcgacccc 21540 gggttcttcg ggatctcgcc gcgcgaggcg ctgtcgatgg acccgcagca gcggctgctg 21600 ctggagacca cctgggagac cttcgagcac gccggcatcg acccgaccgc gcagcgtggg 21660 agccggaccg gcacgttcat cggcgccagc taccaggact atgcctccgg ggcgcccgcc 21720 gccgaggggg ccgagggcca catgatcacc ggcacgctcc cgagcgtgct gtccgggcgg 21780 gtcaactacc tgttcggctt cgagggcccg gccgtcaccc tggacaccgc gtgctcgtcg 21840 tcgctggtgg cgatgcacct ggcgtgccag tcgctgcgca ccggggagag caccctcgcc 21900 ctggccggtg gcgtcagcat catgtccacc ccgatgtcgt tcgtcgggtt cagccgccag 21960 cgcgcgctgg ccgaggacgg ccgctgcaag gcctacgccg acggcgccga cggcatgaca 22020 ctcgccgaag gcgtcggtct ggtcctgctg gagcgactgt ccgacgcggt ccgcaacggg 22080 cacgaggtac tggccgtcgt gcgtggctcc gcggtcaacc aggacggtgc ctccaacggg 22140 ctcaccgcgc ccaacggccc gtcccagcag cgcgtgatcc gccaggcgct cgccggggcc 22200 ggggtcgcac cggaggagat cgacgtcctg gagggccacg ggaccggcac cgcgctgggc 22260 gacccgatcg aggcccaggc gctgttcgcg acctacgggc gggaccggga caccgaccgg 22320 ccgctgctgc tcgggtcggt gaagtccaac atcgggcaca cccagatggc ctccggtgtc 22380 gcgagcgtga tcaagctggt ccgtgcgctg caggagggtg tcgtccccag ctcgctgcac 22440 atcgaccagc cctccacgca cgtcgactgg tcctccgggg cgatcgacct gctcaccgag 22500 cgcaccgcgt ggcccgagac cggccgcccg cgccgggcgg cggtgtcgtc gttcgggatc 22560 agcggcacca acgtgcacac gatcctcgag caggccccgg ccgtccccgc cgccgcaccc 22620 gccgtgccgc tcccggacga cgtcgtggcc ccggtgctgg tctccggccg cggcgagacc 22680 gcgttgcgcg accaggccgg ccgcctgctg gacctgctcg acgagcggcc gcagctgcgg 22740 cccgccgagc tggcgcacgc gctgggcacc acccgcgcgg ccctggagca gcgtggcgcc 22800 gtggtcgccg gcgaccgcga cgagctggtc cgcggcctca ccgcgctgcg cgacggcggc 22860 accgcgcccg ggaccgtccg gggcaccgcc ggtcgtggcc gcaccgcgtt cctgttcacc 22920 ggacagggca gccagcgggc cggggcgggc gccgagctgt acgcccggta cccggtgttc 22980 gccgacgccc tcgacgacgt cgcggcccgg ctggacaccg acgccggcgg cccgccgctg 23040 cgcgaggtcc tgttcgccga gcccggctcc gacgaggccg ccctgctgga gcgcaccggg 23100 cacgcccagc ccgcgctgtt cgcgctcgag gtcgcgctgt tccggctcct cgagtcgtgg 23160 ggcgtcgtcc ccgacctgct cgccgggcac tcggtcggcg agatcgccgc cgcgcacgtc 23220 gcgggcgtcc tgtccctcga cgacgcctgc accctggtgg ccgcccgcgg ccggctcatg 23280 gaggcgctgc ccgcaggggg cgcgatggtc gccgtcgagg cggccgagga cgaggtggcg 23340 ccgctgctca ccgacggcgt cggcatcgcc gcggtgaacg gcccggccgc ggtcgtcgtc 23400 tccggcgacg tcgacgaggt cgacgcggtc gccgcccggc tcgccgcgca gggccggcgc 23460 acccaccggc tgcgggtctc ccacgcgttc cactcgccgc tgatggagcc gatgctcgac 23520 gagttccgcg ccgtggtctc ggggctggac tacgcggcac cggcgatccc gatcgtctcc 23580 accgtcaccg gcaccctggc caccgccgac cggctcaccg accccggcta ctgggtcgag 23640 cacgtccggg ccaccgtacg tttcgccgac ggggtcgcca ccctggccgg gcagcacgac 23700 gtgcgcacct tcgtcgagct cggaccggac ggcgtactgt ccgcggccgc gcgcgacacc 23760 gtcggcgacg agccgggcac cgcgctgctc gcgctgctgc gcaaggaccg ccccgaggtg 23820 cgcacggtgc tcgccgcggt cgccggcgcc cactgccacg gcgcccgcct cgaccggcgg 23880 gcgctgctcg ccgggtacgg ccacgggcgg gtcgccctcc cgtcgtatgc gttccagcga 23940 gagcggtact ggccggagac ggcggccgcc gccgtgcccg agggcaccgg tgccgacgcc 24000 gagttctggg ccgccgtcga gcgcgacgac gtcgagggac tggtcggctc gctcggcctg 24060 gacgacgcca ccgtctccgc gatggtcccg gcgctgaccg catggcgtcg ccgccgcggc 24120 gagcaggcca cccgggacgg ctggcgctac cgcatcacct gggccccgcg cggcgggtcc 24180 ccggccggcg gcgacctcga cggccgccgc ctcgtgctgg tcccgcagac ctaccgcgac 24240 gacgcgaccg ccgcgtgggc cgccgatgtc gaggccgccc tcggcggggg cgggctcgag 24300 cgcgtcaccg tgaccggcac cgaccgcgcc acgctggccg cggcggtcac cgcggccgcg 24360 ggggagggcc cggagttcgc gggcgtcctg tccctgctgc cgttcgccga cggcgacgcc 24420 ggacaccccg gcgtgcccgc cgcgctgagc ctcaccacga ccgccgtcca ggcactcggc 24480 gacgccggtg tcgacgcccc gctgtggacc gtcacccggg gtgcggtggc cgtcggacgc 24540 tccgaggagg tcaccgagct ggaccaggcc gccgtctggg gtctgctgcg gaccgccgcc 24600 ctggagctcc ccggccggat cggcggcacc gtcgacctgc ccgccgtggt cgacgcaccg 24660 gccgcccgcc ggctgcgcgg cgtgctcgcc gcgaccgacg gcgaggacgc ggtcgccgtg 24720 cgggcctccg gggtcttcct gcgcaggctc gtgcacgcac ccgcccgcgc cggggccaca 24780 ccggccccgt tcgacgccac caccggcacc gtcctgatca ccggcggcac cggcgggatc 24840 ggcggtcacg tcgcgcgccg gctcgcccgc gagggagccg cgcacctgct gctcgccgcg 24900 cgccgcggcc ccgacgcccc cggcgccgcg gccctgcgcg ccgagctgga ggagctcggc 24960 gcccgggtca ccgtcgccgc ctgtgacgtc gccgaccgcg aggcgctcgc cgcgctgctc 25020 gacacggtgc ccgccgagct gccgctggtc ggggtcttcc acaccgcggg cgtgctcgag 25080 gaccgtgtcc tcgacgcgct gaccccgcag agctactccg gggtgctgcg ggccaagacc 25140 gtcgccgccc agcacctcga cgagctgacc cgcgacagcg acctcgccgc cttcgtgctg 25 200 ttctcctcga ccgcaggcat gatcggcgcc gccggtcagg gcaactacgc cgccgccaac 25260 gcctacctcg acgccctcgc cgagcaccgc cgcgcccgcg gcctgcccgc gttgtcggtg 25320 gcgtggggcc cgtgggacgg ctccggcatg gtcgccgacg ccgccgaggt cgccgcccgc 25380 gtacggcgcg gcggcttcgc accgctcgac ccggagacgg cggcggtcgc gctgctgcgg 25440 gccgtcgacg ggagccggga aggtggggag accaccctcg cgatcgccga catggactgg 25500 gagcggttcc tgcgcgcgtt cgggtccgtc cggccgatgc cgctggtcgc cgatctcccc 25560 gaggtcgccc ggctcgccgc ccccaccacc ggtggggaca ccggtaccgg gctgcggggc 25620 cggctcgcgg ccctgcccga cgacgaacgc ctcggcgtcg tgctcgacgt actgcgcacc 25680 caggtcgcgg ccgtgctcgg acacgccgac ccgcgcaccg tcgacgacga ccgcgcgttc 25740 cgcgacctcg gcttcgactc gctgaccatc ctggagctgc gcaacgcgct caacgccgcc 25800 accgggctgt cgctgcccgc gacgctggtc tacgaccggc ccaccccgcg ggagatggcc 25860 gggttcctgc tcggcgagct gctcggcacg ctgcccgagc agcggggccc ggtccgcacg 25920 agcgccgccg tggacgaccc gatcgtcgtc gtcgggatgg cctgccggtt ccccggcggg 25980 gtccgcaccc ccgaggacct gtgggagctc gtggcccgcg gcgatgacgg catcaccggg 26040 ttccccgacg accgcggctg ggacctcgcc gcgctcggcg acggggcctc ggccacgctg 26100 cggggtgggt tcctggacgg cgtcgcggac ttcgacgccc ggttcttcgg catctccccc 26160 cgcgaggcgc tcgccatgga cccccagcag cggctgctgc tggagaccac ctgggaggcc 26220 gtcgagcggg ccgggatcga cccggcgacg ctgcgcggct cggccaccgg cgtcttcgtc 26280 ggcaccaacg gccaggacta cgcgacgctg ctgcgccggt cggccgacga cgtctccggc 26340 tacgccgcca ccggcaacac cgccagcgtc atgtccggcc ggctgtccta caccctcggc 26400 ctggaggggc ccgccgtcac catcgacacc gcctgctcct cgtcgctggt cgccctgcac 26460 tgggccggac gggcactgac cgacggggag gccgacctgg tcctggccgg tggggtctcg 26520 gtcatgtccg gaccggactc gttcgtcgag ttctccaccc agggcggcct cgccccggac 26580 gggcactgca agcccttctc cgacgacgcc gacggcaccg cctggtccga gggcgtcggc 26640 atgctggtgc tggagcgcct gtccgacgcc cgccgccacg gccaccgcgt gcacggcgtg 26700 atcggcggct cggcgatcaa ccaggacggc gcctccaacg ggctcaccgc ccccagcggg 26760 ccgtcccagc agcgggtcat ccgccaggcg ctggccgacg ccgggctcac cccggccgac 26820 gtcgacaccg tcgaggcgca cggcaccggg accaccctcg gcgacccgat cgaggcccag 26880 gccctgatcg ccacctacgg ccgcgaccgc gacaccgacc gcccgctgca cctgggcacg 26940 gtcaagtcca acatcggtca cacccaggcc gccgccggcg tcgccggggt gatcaagatg 27000 ctgctcgcga tgcggcacgc cacgctgccc cgcaccctgc acgccggcac gccgtcctcg 27060 cacgtcgact ggagcgccgg caccgtggcc ctgctcgacg aggcccggga ctggccggag 27120 accggcggca cccgccgggc cggtgtctcg gcgttcgggg tcagcggcac caacgcccac 27180 gtcatcgtcg agcaggcacc gcccgccccg gagaccgccg ccgccgagct gcccggcgag 27240 gtcccgtggg tgctgtccgc ccgcaccccc gcggccctgc aggagcaggt cgaccgcgtg 27300 gtcggcgctg ccggtgggca caccgccacc gacgtcgccg cgaccctggc cggtggccgc 27360 accctgttcg gccaccgcgc cgtgctcctc gccggcccgg acgggatccg cgaggccgcc 27420 cgcggcaccg caccccgcac ccccggccgg acggcgttcc tgttctccgg gcagggcgcc 27480 cagcacgccg ggatgggccg tgcgctccac gagcgccacc ccgcctacgc cgaggccctc 27540 gacgaggtcc tcgcccggtt cgacaccctg ctcgacgcac cgctgcggga cgcgctgttc 27600 gccgagcccg gctcagcggc cgccgaccgg ctcgacgaga ccggcaccac ccagcccgcg 27660 ctgttcgccg tcgaggtggc gctgtaccgg ctcctggagt cctgggggcg caccccggac 27720 ctggtcgccg ggcattcggt cggtgagatc gccgccgcgc acgtggccgg cgtgctctcc 27780 ctcgacgacg cctgcgcgct cgtcgcggcc cgggcctcgc tgatgcaggc gctcccggcc 27840 gggggcgcga tggtcgcggt cgaggccacc gaggacgagg tcacaccgct gctcaccgac 27900 ggcgtcgcga tcgccgcggt caacgggccc gcctcgctgg tcctctccgg ggacgccgac 27960 ggggtcggcg cgctcgccga ccggctggcg gccgacggcc gccggacccg gcggctgcgg 28020 gtcagccacg ccttccactc gccgctgatg gacgcgatgc tcgacgggtt cgccgccgcg 28080 atctcgggga tcaccttcgc cgcaccgcgg atcccactgg tctccacgct caccggtgcc 28140 ctcgccgggc cggagctggg cgagcccggc tactgggtgc gtcacgtgcg ggaggccgtg 28200 cggttcgccg acggtgtccg cgccctgcac gaggccgggg cgaccgtgtt cgccgagatc 28260 ggcccggacg cggcgctgct cgccccggcc cagcagaccc tggacacggt ggcaccggcc 28320 gacggcccgg cagcggtggt cgtcgcgctc cagcggcgcg accgcgacgc cggcaccgcg 28380 ctgctcgagg gcctcgccgt cctgcacgtc cacggcgccg gaccggactg ggcggccgtg 28440 ctgcccgccc gcgggccggt cgagctgccg acctacccgt tccagcggga acgctactgg 28500 cccgagcccg gcacgccggg cggcggcgcc ggaccggccg acccggccga ctccgccttc 28560 tgggcggctg tcgagcggga ggacctggag agcctgtcgg gctcgctcgg tgtcgacggc 28620 gacacgctcg ccacgatggt ccctgcgctg tccgcctggc gccgccgcca cggcgccgag 28680 tccgcggccg cgacctggcg ttaccgcgag acgtggaccc cggtcccgac cccggcggcc 28740 gcggtcaccg ggcggacgct cgtgctggtg tccgccggtg ccgacgcctg gaccgacgcc 28800 ctcgtgaccg cgctcgacgc cgagaccgtg gtcgtcggcg acggctccac cgacgagctc 28860 accgtggccc tcggcgtcct cgacgacgcc gaccggcccg tggaccgggt ggtgtcgctg 28920 ctcgccgccg ggacgtccgg gctgccgtcc gggcccgccc gggcgtcggc gctgctcgcc 28980 gcgctcgccg cggccgggat cgacgcaccc ctgtggtgcg tcacccgcgg cgcggtcgcc 29040 gccgagggca ccacccccgc ccccggccag gccgcgctgt gggggatggg ccgggtcgcc 29100 gcgctggaga ccccgcagcg gttcggcggt ctcgccgacc tgcccgcggg ccccgacgcc 29160 gtcgccgccg ccgccgcgac cgcactcgcc gcgctgctca ccgagccggg cggggagagc 29220 gagatcgcgg tgcgcgccac cggcgcctac gcccgccgcc tcgtgcgggc gggcggtgcc 29280 gagggcacgg ccgccgcccg ctggcgcccg cacggcaccg tgctggtcgt cggcggcacc 29340 ggggcgctgg gccgccgcgc cgcgcgccgg ctggccgccg acggcgccac gcacctggtg 29400 ctcaccgcgc cctcggccgc ggcgtcggtc gacaccgacg ccgtcaccgc cgagctggcc 29460 gacctcggcg tcgcggtcac cgtgtccgac gccgaccccg ccgacccggc cgcgctcgcg 29520 gcgctgctcg acggtgcccc cgacgccccg accgcggtcg tccacgccgg tgaggcgctc 29580 ggcgacgccg gcctcgccga cgtcctggcc cccgtcgagg ccctcgccac ggcgctcacc 29640 ggccccgcga ccgcacacga cctcgacgcg gtcgtcctgt tcggctcgat cgccggggtc 29700 tggggggtgc gcggacgggc ggtcgaggcc gccgcgggcg cccacctcga cgcagtcgcc 29760 cgcagcctgc gcgggcgcgg tgtccccgcg acggccgtcg cctggggcgc ctggaccgat 29820 cttgccgacc gctcgacggc ggcccaccta cggatgaacg gcctgcccgc gatggacggc 29880 gacgcggcga tggccgcgct cggccgcgcc gtcgccgacg ggtcggtcgc cgagaccgtg 29940 gccgacgtgc gctgggagac cttcgccccg gcacaccacg acgcccgcgc caccaccctg 30000 ttcgacgcgc tgcccgaggc ccgcaccgcg ctgtccggcg cggcccgcga gcgggccggc 30060 cgcgaggccg ccgcgagcgg gtacgggcag tggctcgccg agcagcccga ggcggagcgg 30120 gacacgatcc tgctcgacct cgtcgccgcg acggcgacga cggtgctcgg tctgaccgac 30180 ggcgagccgc tcgaacccga cctgcccttc cgggacctcg gcttcgactc gctcaccgcg 30240 gtggacctgc gcaaccagct caccgccgcc accggtgtcg cgctgcccgc caccctggtc 30300 ttcgaccacc cgaaccccgc cgcgctggcc gcgcacctgc gcggcgagct gctcggcggg 30360 ggtgacggtg ccgccgagcc cgtcaccctc gccgcgtccg ccaccgggga cgacccgatc 30420 gtcatcgtcg gcatggcctg ccggtacccg ggtggcgtcg cctcgcccga ggacctgtgg 30480 cagctcatgg ccgacgacgt cgacgccgtc ggggcgttcc ccgacgaccg cggctgggac 30540 ctggagaccc tcgccggtga cggccccggc cgcagcgcca cggcccaggg cgggttcctg 30600 cacgacgcca ccgacttcga cccgggaccg ttcggcgtct cgccgcgcga ggcactggtg 30660 atggacccgc agcagcggat cctgctggag acctcgtggg aggcgctgga gcgcactggg 30720 atcgacccgt cgtcgctgcg gggcagcgcc gagtacggcg tgttcgtcgg cggcggctcc 30780 ggtgactacc ggccgcccgc cgaggccggg cagtggcaga ccgcccagtc cgccagcctg 30840 ctgtcgggcc gcgtcgccta caccttcggt gtccagggcc cgacggtctc ggtggacacc 30900 gcctgctcct cgtcgctggt cgcgctgcac ctcgcggcgc aggccctgcg ggcgggggag 30960 tgctcgatcg cgctggccgg cggcgtcacc gtcatggcca ccccggtcgg gttcgtcgag 31020 ttcagcgcgc agggcgcgtt gtcgccggac ggtcgctgcc gcgccttctc cgacgacgcg 31080 aacggcaccg gctggtccga gggcgtcggc atgctggtcg tcgaacggct ctccgacgcc 31140 cgccgccgcg gccaccgcgt ccacgcggtg ctgcgcggct cggccatcaa ccaggacggc 31200 gcctccaacg gcctcaccgc acccagcgga ccggcccagc agcgcgtcat ccgccaggcg 31260 ctggccaacg cccggctcac cccgggcgag gtcgacgccg tcgaggcgca cggcaccggc 31320 accaccctcg gcgatccgat cgaggcccag gccctgctcg ccacctacgg gcaggaccgc 31380 gaccggccgg tgctgctcgg ctcgctgaag tcgaacatcg gccacaccca ggccgcgtcg 31440 ggcgtcggcg gcgtcatcaa gatggtgctc gccatggagc acggcgtgct gccgcgctcg 31500 ctgtacgcgg agaacccgtc ctcgcacgtg gactggaccg cgggcgacgc acagctgctc 31560 accgcgccca ccgggtggcc cgagaccggg cgtccgcgcc gggccgcggt gtcctccttc 31620 ggcgcgagcg gcacgaacgc gcacgccatc ctggagcagc ccccgcacgc cgacgtcgtc 31680 cggcgcgccg acgacacccc cgacgacccc ggcgcggtcg cggtcctgct gtccggccgc 31740 accgaggccg cgctgcgtgc ccaggccgac gagctggtcg cccacctcgg cgagcacccg 31800 gacctgcggc tgcgcgacct ggcccgcgcc ctggccacga gccgtgcgac gttcgaccac 31860 cgggcggcgg tcaccgccac ctgccgcgac gagctcctcg cagggctcac cgccgtcgcc 31920 cacggcgaca ccgcaccgca ggtcgcgacc caccgcctgg agcgcagcgg ccgcagcgcc 31980 gccctgttct ccgggcaggg cgcgcagcgg ctcgggatgg gccgcgagct gtacgaacgg 32040 cacccggtgt tcgccgacgc cgtcgacgcg gtgctcgccc ggctcgacgg tcacctcgac 32100 cggccgctgc gcgacacgat gtgggggacc gacgccgacg ccctcgccga gaccggggcg 32160 acccagccgg cgctgttcgc cgtcgaggtc gcgctgtacc ggctcgtcga gtcctggggg 32220 gtccgcccgg acttcgtggc cgggcactcg atcggcgaga tcagcgccgc gcacgtcgcc 32280 ggggtcctcg acctcgacga cgcctgccgg ctggtcgccg cccgcgcccg tctgatgcag 32340 gcgctcccgg ccgggggcgc gatggtcgcc gtcgaggccg acgaggacga ggtgaccccg 32400 ctgctcaccg acggcgtcgc gatcgccggg gtgaacgggc ccggctcggt ggtcctgtcc 32460 ggtgacgacg acgcggtgac cgccctggcg gcggtcctcg ccggcgaggg acggcgcacc 32520 agcaggctgc aggtcagcca cgcgttccac tcggcccgga tggacccgat gctcgccgag 32580 ttccgcacgg tcgccgagga gctcgactac cacgagccgc gcatcccggt ggtgtccaac 32640 ctgaccggcg ccgtcgccgc ggcgcacgag ctctgctcgg cggagtactg ggtgcgccac 32700 gtccggggca ccgtccggtt cgccgacggt gtccgtgcac tcgccgcccg cggcgtcagc 32760 accttcctcg agctcggccc ggacgcggtc ctgtcggcac tcgtgccgcg cagcgcgccg 32820 gacgcgctcg ccgtccccgc cctgcgccgc gaccgcgacg aggaggcgac cctggtcgcc 32880 gcgctcgccc ggctgcacac ccacggcgcg ggcccccggt gggaggcgtt cttcgccggc 32940 cacgacaccc gccgggtcga cctgccgacc tacccgttcc agcgcgaccg gttctggccg 33000 gacgtcatgc ccggccagga gacccgggcg gtcgcgcccg ccggcccggg cacccccgac 33060 gagatcgacg ccgccttctg ggaggccgtc gcgcaggagg acttctccgc actcgagaca 33120 cagctcgacg tcgagggcgc ggcgctgtcg gcggtgctgc cggccctgat ggactggcgc 33180 agccgccggg cgcaggaggc ccggctggcc cgctggcggc accggatcgt ctggaagcgg 33240 ctgaccggct ccgcgaccgg gcggcgccgc acccccgagg gcacctggct ggccgtgctc 33300 ccggagggca ccgccgtcga cccgtgggtg accacggtgc tcgacgggat cggcaccgcc 33360 gtcgtgaccg tcgagaccgg ctccaccgac cgcgcggtgg tcgccgccgc actcaccgcg 33420 cagctgcccg ccgggacccc ggtcgccggg gtcgtgtcgc tgctcgcgct gcgcgacgag 33480 ctcaccggcg acgtccccga cggggtcggg ctcaccaccg gcctgctcca ggccctcggg 33540 gacgccgggg tcgacgcccc gctgtggtgc ctcacccgcg gcgcggtctc caccgggacc 33600 accgaccgcc cggcacggcc gctgcaggcc gcgatctggg gcctggggcg ggtcgcggcg 33660 ctggagtacc cgcagcgctg gggtggcctg gccgacctgc ccgaggaccc cgacccgcgg 33720 gccgccgccg cgctcggcgc ggtactggcc gggctcgacg acgaggacca ggtcgccgtc 33780 cgcggcgccg cggtcctggc gcggcggctc gtcccggccc cgccgcggga ggacacgacg 33840 acggcgtgga ccccgaccgg caccgtcctg atcaccggcg gcaccggtgc cctcggcggg 33900 cacgtggcgc gacggctcgc cgccgacggg gcgcagcacc tggtgctgct cggtcgccgc 33960 ggcccggacg ctcccggtgt ggacggactg cgtgcggagc tggaggcact cggtgcgggc 34020 gtgaccgtgg cggcctgtga cgccgccgac cgggggcagc tgtccgcggt gctcgcggcg 34080 atcccggccg accggccgct gaccggcgtc gtgcacgccg cgggcgtgct cgacgacggg 34140 atcctggacc gcctcacccc cgagcggtac cgggaggtct tccggtccaa ggtcaccgcg 34200 gcgctgctgc tcgacgagct gacccgcggc ctcgacctcg acgcgttcgt cctgttctcc 34260 tccgcgtcct cggccgtcgg caaccccggt caggccaact acgccgcggc caacgccgtg 34320 ctcgacgcgc tcgccgagca gcgccgggcc cgcggcgacg ccgccacctc gatctcctgg 34380 ggtgtctggg gcggcggcgg aatggcgggg gccggctccg ccgacgacgc ggcccgccgc 34440 accgggatcg gtgcgatgga cccggcgctc gcggtcgaga ccatgctccg cctgatcgcg 34500 gggaccgcgc ccaccgcggt cgtcgccgag gtcgagctcg accggttcgc cggcgcgttc 34560 ggcggcaccc gccccagccc gctgctgcgc gagttccccg gctacgccga gctcgtcgcc 34620 ggccgggccg ggacccggcc cggcgcggcg gaggacgacc tcgccgcgac gctcgtggca 34680 ctgccgcccg cgcggcggct ggacacggtc gtggacctgg tgcggtcgcg tgccgcgcag 34740 gtcctcggct atcccggcag cgacgacgtc ggggccgaac ggtccttccg tgacctcggg 34800 atcgactccc tgggggcggt cgagctgcgc aaccagctcg gcgccgccac cggcctgggc 34860 ctgccggcca cgctggtctt cgaccacccg acccccgccg ccgtcgcccg gtacctgctc 34920 gacgagctgg ccggagacga caccggggcc gacggcgagg aggccgggat ccgggcagca 34980 ctggccaccg tgcccctgga acggctgcgc gagctcggcg tgctggagcc gctgctgcgg 35040 ctcgtcggcc gcggcgagga aaccgcagcc gacgacgaca ccgggaccgg tcccggtggc 35100 agcgaggtcg acgcgatgtc cgtcgacgac ctggtgcggg ccgcgctcga cggccggccc 35160 gacgacctgt agcgcgagtg agggaacaga cgatgaacga gaagcacgcg tccggcaccg 35220 ccggtggcaa cgacgtcgtc accgcgctcc gcgccgcggt gaaggagacc gaccggctgc 35280 gccggcagaa ccggatgctg cagtccgcgg ccaccgaacc gatcgccgtc gtcggcatgg 35340 gctgccggtt ccccgggggc gtcgactcgc ccgaggcgct ctgggacatg gtcgccgccg 35400 gcaccgacgt gatctccggg ttccccaccg accgtggctg ggacctcgac gcgctgcacg 35460 ccggcggcac cgacgcccgc gacaccgaga tcagcatgca gggcgggttc ctggacgggg 35520 tcgccgactt cgaccccggc ttcttcggta tctcaccgcg cgaggccgtc accatggacc 35580 cgcagcagcg gctgctgctg accaccgcct gggaggcgat cgagcgcgcc ggcatcgacg 35640 cggccgggct gcgcggcagc cgcaccggcg cgttcatcgg caccaacggg caggactacg 35700 cctacctggt ggtccgctcg ctcgacgacg cgaccggcga cgtcggcacc gggatcgccg 35760 ccagcgccgt gtccgggcgg ctgtcctaca ccctcgggct cgagggtccc gcgctcaccg 35820 tcgacaccgc ctgctcgtcc tcgctggtcg cgctgcacct cgccgtggcc tcgctgcgca 35880 acggcgagag ctccctggcc ctggccggcg gcgtcaacgt catgtcgacg cccgggtcgc 35940 tggtcgagtt cagccgccag ggtgggctgg cccgcgacgg gcgctgcaag gccttcgccg 36000 agggcgccga cggcaccggc tggtccgagg gcgccgggat cctggtgctg gagcggctgt 36060 ccgacgcccg ccgtctcggg cacccggtgc tcgcggtcgt ccgcgggtcc gcggtcaacc 36 120 aggacggcgc gtccaacggg ttcaccgcgc cgaacgggcc gtcccagcag cgtgtcatcc 36180 gggccgcgct cgccaacgcc gagctgtccg ccggcgacgt cgacgccgtg gaggcgcacg 36240 gcaccggcac accgctcggc gacccgatcg aggcgcagag catcctcgcc acctacgggc 36300 gggaccgcga gcggccgctc gcgctcggct cggtcaagtc gaacatggga cacacccagg 36360 ccgcgtccgg tgtcgccggg gtcatgaaga tgatcatggc gatgcagcac ggtgagctgc 36420 ccaggacact gcacgtggac cgcccctcga cccacgtcga ctggtccgcg ggcgcggtcg 36480 agctgctcac gcaggcgcgc ccgtggccgg ccgtggagcg gccgcggcgc agcggtgtgt 36540 cctccttcgg ggtcagcggc accaacgccc acgtgatcgt cgagcaggcg cctgccccgg 36600 ccgagcccgc cgccgagccc gccgcccgcc tcccgcaggc gctggcctgg acggtctcgg 36660 cccgcacccc cgccgccctg cgcgaccagg ccgccgcgct gctcgcccac gtcgagcgcg 36720 accacgcccc gaccgcgctg gacaccgggt actccctcgc caccacccgc gccgtgcagg 36780 aacaccggct cgccgtcgtc accggaccgg acggacgggc cgggcgcgcg gcgctcgccg 36840 gctggctgga gcacgggagc gcgccgggcg tcgccctcgg ccacgtcacc ggacgccccc 36900 ggctcgccgc gctgttctcc gggcagggcg cccagcggct cggcatgggc cgcgagctgt 36 960 acgagcggca cccggtgttc gccgccgcgt tcgacgaggt cctcacgctg ctcggggacg 37020 acctgcggga cgtcgtgtgg ggcaccgacg ccgccgcgct cgacgagacc ggggcgaccc 37080 agcccgcact gttcgccgtc gaggtcgcgc tgtaccggct cgtcgagtcc tggggcgtga 37140 ccccggacct cgtcgccggc cactcgatcg gcgagatcgc cgccgcccac gtggcgggcg 37200 tgttctccct cgacgacgcc tgccggctgg tcaccgcgcg cgcctcgctg atgcaggcgc 37260 tgccccgcgg cggcgccatg gtcgccgtgg aggcgaccga ggacgaggtc accccgctgc 37320 tcaccgacgg tgtcgcgatc gcggcggtga acgggccgtc gtcggtcgtc gtgtccggcg 37380 aggaggacgc caccctcgcc gtcgccgccc ggctcgccga gcagggccgg cgcaccagca 37440 ggctgcgggt gtcgcacgcg ttccactcgc cgctgatgga ccccatgctg gccgagttcg 37500 cggccgtcgc cgagggcctg tcctacgccg agccccggat cccgctggtc tccaccctga 37560 ccggggcacc cgccacggtg gagctgtgcg atcccgggta ctgggtgcgc cacgtccgtg 37620 aggccgtgcg gttcgccgac ggggtcggtg ccctcaccga cgccggcgcc cggatgttcc 37680 tggagatcgg cccggccggg gtgctcaccg cgctggccgc acggtccgcg cccgaggcca 37740 ccgccgtcgc gctgcagcgc accgaccgcg gtgaggagga ggcgaccgtc gccgcgctcg 37800 gtgcgctgca cgtcgccggc accgccgtcg actgggaggc cgtccacgcc ggcaccggcg 37860 cccgccgcac cgacctgccc acctacgcct tccagtacga gcggtactgg ccgaaggcgg 37920 tgcagcgctc gggcgacgcg gccgggctcg ggctggcccc cgccgaccac ccgctgctcg 37980 gcgccgccat gtccgtggcc gggtccgacg agctgctgct caccggcacg ctgtccctga 38040 ccacccaccc gtggctcgcc gaccacgtcg tcggcgggat ggtcttcttc cccggcaccg 38100 gcttcctcga gctcgccgtc cgcgccgccg accaggccgg ctgcgaccgc gtcgaggagc 38160 tcatgctcgc cgcgccgctc gtgctgcccg ccaccggcgc ggtccagatg cagatcgccg 38220 tcggcgcggc cgaccccgac ggcacccgcg acgtcagcgt gtacgcccgc cccgcgcagg 38280 accccgacgc cgactggacc cggcacgcca ccggccgggt cgcgcccggc gagcaggtcg 38340 cggagttcga cgcccgcacc tggccgcccg ccggggccga gcccgtcgac atcgacggcc 38400 tctacgaccg ctacgccggc aacgggctgc agtacggccc ggtcttccgc ggcctgcagg 38460 cggtgtggcg ccgtggcgac gaggtcctcg ccgaggtcgc gctgcctccg gccggggccg 38520 aggacgcggg cgacttcggc ctgcaccccg ccctgttcga cgccgtcctg cacagcacgg 38580 tgttcgcctc cgccgacggg gacgaccgca gcctgctgcc gttcgcctgg aacggggtgt 38640 ccctgcacgc cggcggcgcg accgcgctgc gggtgcgcgt cacctccgcg gggcccgacg 38700 ccgtccggat cagcgcggcc gacccgcagg gcaacccggt gatctcggtg gactcgctga 38760 ccctgcgcgc cgccgggccg gacgcggcgg gcccggaccg ccgggacccg ggatcgctgt 38820 tccggatggg ctgggtgccg cagaccctca ccccccggca caccccggcg acctgggcgg 38880 tcctcgacgg cgcgggagcc ggcgatgtcg ccgccgcgct gaccgccgag cccgccgccg 38940 tgtccaccgt gcggacggtc accggtctcg cggacctcca cgacgccgac ccgcccgacc 39000 tggtcgccgt cccgctgacc gcccccggct ccgtcgacac cggccccgcc gccgcacaca 39060 ccctgacccg cgaggtcctc gcgctgctcc agcagtggct cgccgacgac cggctcgccc 39 120 ggacccgcct cgtcgtactc acccgcggcg ccgtcgccga cggctccgga tcgccgctcg 39180 acctcgccac cgcacccgtg tggggcctgc tgcgctccgc gcagtcggag aaccccggcc 39240 ggctgctggt cgccgacctc gacgacaccc cggcgtcgct cgccgcggtc gcgcagctgc 39300 ccgccctgtt cgacgccgac gagccgcagg cgatcgtccg ggacggcgcc gtgcgggtcg 39360 ggcggctcgc cacgctgctg tccggcgccg cgctcgtccc gccggccggg accccctggc 39420 ggctcggctg ccgcgccaag ggcagcctcg acggcctcga gctggcgccg cacccggacg 39480 tcctcgcccc cctgcgcggg cacgaggtcc gcgtcgggat ccgcgccgcg gggctgaact 39540 tccgcgacgt cctcaacgcg ctcgggatgt accccggcga cgcggggctg ttcggctccg 39600 aggccgccgg cgtcgtcacc ggggtcgggc ccgaggtcac cacgctcgcc cccggcgacc 39660 gcgtcaccgg catgctgttc ggcgggttcg gcccgcacgg cgtcaccgac gagcggctgc 39720 tcaccaccgt gcccgacggc tgggactggg agaccgccgc gtcggtccca ctggtgttcc 39780 tcaccgccta ccacgccctg gtcgacctgg ccgacctgca gcccggtgag aaggtgctga 39840 tccacgccgg agcgggcggc gtcggcatgg ccgcggtgca gatcgcgcac cacctcgggg 39900 ccgaggtgta cgcgacggcg tcggagccca agcaggatgt cctgcgcggg ctgggcgtcg 39960 caccggacca catcgcctcc tcgcggaccc tggagttcgc cgggaccttc gccggggccg 40020 ggatcgacgt ggtcctcaac gccctgtccg gggagttcgt cgacgcctcg atgggcctgc 40080 tgggcgacgg tggccggttc ctggagatgg gcaagaccga catccgcgac cccgcggacc 40140 tgcccgacgc gatcacctac cggttcttcg acctcggcgc cgtcgacccg caccgcatcc 40200 agcagatgct ggtcgcgctg gccgggctgt tcgccgacgg cgcgctgtcc ccgctgcccg 40260 tgcgcagctg ggacgtgcgc cacgccgtcg aggcgttccg gttcatgagc tccgcccgcc 40320 acgtcggcaa gctcgtgctc accgtcccgc cgccgctcga cccgcagggc accgtgctga 40380 tcaccggcgg caccggcggg ctcgccgccg cgctggcgcg ccacctcgtc gccacccacg 40440 gcgtggcgca cctgctgctc gccggccgcc gcgggcccga cgcccccggc gcgaccgcgc 40500 tgcgggagga gctgaccgcg gccggtgcgc aggtcaccgt cgccgcctgc gacgtcgccg 40560 accgcgacgc gctggccgcc ctgctcgacg gcgtcgaccc ggcgcacccg ctcaccgccg 40620 tcgtgcacac cgcgggcgtc ctcgacgacg gcaccgtcac ctccctgacc cccgccgccg 40680 tcgacgccgt gctggccccg aaggtcgacg ccgcctggca cctgcacgac ctcacccgcg 40740 accacgagct cgccgcgttc gtcctctact cctccaccgc cggggtgatg ggcggacccg 40800 gccagggcaa ctacgccgcg ggcaacacct tcctcgacgc actcgccgcg caccgccacg 40860 cactggggct gcccgccacc tcgttggcct ggggcgcctg ggagcagggc gccgggatga 40920 ccggtggcct gtccgaccac gacgtcgccc gggtcgggtc cggcggcatg ccgctgctga 40980 gtgtggagcg cgggctcgcc ctctacgacg ccgcgaccct cgccgcggag cccctcgtcg 41040 tcccgctcgg cctgaccggc ggcgggaccc cgccgaccgc aggcggcgtc cccgccgtgc 41100 tgcgcggcct ggtccgctcc ggcggccgcc gccgcgccgg caccgcgggc gtcgcccggg 41160 ccgggctggc cgagcgcctc gccgggctcc ccgccgacgg ccggggcgcg ttcctcgtcg 41220 agctggtccg tgccgaggcc gcgaccgtgc tcggcctcgg ctccggggac ggcgtcgacg 41280 cccgtcacga gttccggcgg atcgggttcg actcgctcac cgcgatcgag ctgcgcaacc 41340 ggctgggcag cgcgtccggg ctgaccctgc ccgcgacgct gatcttcgac tacccgaccc 41400 cggagcggct ggccgcctac ctgctcgagg agctcgcggg cgaggacacc ggccccgtcg 41460 gcgacggccc cgtggtcgcc cgcgccgacg ccgacgaccc ggtcgtggtc gtcgggatcg 41520 gctgccggtt ccccggcggc gtgggctccc cggagcagct gtgggacctc gtcgcgaacg 41580 gcaccgacgc gatcaccggc ttcccaccgg accgcgagtg ggaccggcac ccgccgctgg 41640 gtggcggtga gcccgccgac ctcaccggcc agggcgggtt cctcgacgac atcgcgggct 41700 tcgacgcgga gttcttcggt atcgccccgc gtgaggcgct ggccatggac ccccagcagc 41760 ggatcctgct ggaggtcgcg tgggaggccg ccgagcgcgc cgggatcgac ccgcacacgc 41820 tgcgcggcag ccgtaccggg gtgttcatgg gggtgtccgg tcaggactac tccggcctgg 41880 tgatgcgctc cgccgacgac atcgcgagcc acgcgaccac cggcctcgcc gtcagcgtcg 41940 tgtccgggcg gctcgcctac gtcctcggcc tggagggccc cgcgctctcg gtcgacaccg 42000 cctgctcctc gtcgctggtg tccctgcacc tcgccgcggc cgcactgcgg tcgggcgagt 42060 gcgacatggc actcgccggc ggcgtcaccg tgatgacgac ccccgcgaac ttcaccggct 42120 tctcccggat gggcgggctg gcgggcgacg ggcgctgcaa ggcgttctcc gactccgccg 42180 acggcacggg ctggtccgag ggtgcggctg tgctcaccct cgaacggctc tccgccgcgc 42240 gccgccacgg gcaccgggta ctcgccgtgg tccgcgggtc cgcggtgaac caggacggtg 42300 cctcgaacgg gctcaccgct ccgaacgggc ccgcccagca gcgggtcatc cgccaggcgc 42360 tggccgacgc cgggctggag cccggtgacg tcgacgccgt cgaggcgcac ggcaccggca 42420 ccccgctggg cgacccgatc gaggcccagg ccgtgctcgc cacctacggc cgggagcggg 42480 acccgcagcg gccgttgctg ctggggtcgg tgaagtcgaa catcgggcac acccagtccg 42540 cggcgggcgc cgcgggactg atcaagatga tcatgtcgat ggcgcacggg gagctgccgc 42600 ggaccctgca cgtcaccgag ccgtcctcgc acgtggactg gtccgacggc accgtcgccc 42660 tggtcaccga gcggaccccg tggccggaga ccggacacgc ccgccgcgtc ggggtgtcgt 42720 cgttcgggat cagcggcacg aacgcccacg tggtgctcga acagccgccc gccacgcagc 42780 cggcacctcc ggacgccgcc accccggatg ccgccgcccc ggacgccgcc ggcccggatg 42840 ccgccgcccc ggaggtcgtc gcctggccgg tgtccgcccg gaccgaggcc gccctcgacg 42900 cccagctcga ccgcctgcgc accgccgttc ccggcctgac cccgaccgcc gtcgcgcgca 42960 ccctcgccac cggacgggcc ctgttcgagc accgcgccgt gctgctcgcc gggcccggcg 43020 ggaccaccga ggccgcccgc ggcgccgccg ccacccgcgg caccgcgttc ctgttctccg 43080 gacagggcgc ccagcgcctg ggcatgggcc gggagctgca cgcccggttc ccggtgttcg 43140 ccgacgcgtt cgacgaggcc gtcgccctgc tcgacgccga gctgggcggc acgctgcgcg 43200 acgtcgtgtg gggcgaggac ccggaagccc tggaccgcac ccggcacacc cagccggcgc 43260 tgttcgccct cgaggtggcc ctgtaccggc tcgtcacctc ctgggggatc cggcccggtc 43320 ggctcgcggg ccactcgatc ggtgagatcg ccgccgcgca cgtcgccggg gtgttctccc 43380 tcgccgacgc gtgccgcctg gtcgccgccc gcgcccgcct gatggacgca ctgcccgcgg 43440 gcggcgcgat gaccgccgtc gaggccggcg aggacgaggt gaccccgctg ctcaccgacg 43500 gcgtcgcgat cgcggcggtg aacgggcccg cggccgtcgt cgtgtccggg gcggccgccg 43560 aggtcgacgc cgtcgccgcc gagctggccg cccgcggcag gcgcaccacc gcgctgcggg 43620 tcagccacgc cttccactcg ccgctgatgg acccggtcct cgacgagttc cgtgccgtcg 43680 tccgggacct cggctacgag ctgcccgcga tcccggtcgt gtcgctgctc gccggggcgg 43740 gatcgccgca cgacctggcc accccggagc actgggtgcg ccacgtccgg gagacggtcc 43800 gcttcgccga cggcctggcg accctgaccg cgggcggggc caccgcgttc ctggagatcg 43860 gtccggacgg cgtgctgtcc gcgccggccc gcgccgtgct ccccgcggtc ggcgacgacg 43920 ccgccgtcgt caccccggcc ctgcgcgccg ggcacggcga accggccgcg ctgctcaccg 43980 cgctcgcccg cctgcacgtg gccggggtcg acgtcgactg ggcggccggg ctcggcggcg 44040 ccgctgccgg ccccggcgcc gacctgccca cctacgcctt ccagcacgaa cggttctggc 44100 cgcggctcgc cgcgggcccg gccaccggca ccggcgagga caccgagttc tgggcggccg 44160 tcgagcggga ggacctcggc ctgctggccg cccacctcga cgtcgacggc gagcggctcg 44220 gcgccgtgct gcccgcactc gcggcctggc gcagccgccg gcgcagcgac gcatcgctcg 44280 accggctccg ttaccgcgag tcctggcgcc cgctgacgct gcccacggcc gtggaaccgg 44340 gccgccacct cgtgctcgtc ccggccgtcg cggccgggga cccctgggtc ggcgaggtcg 44400 tggacgccct cggaccggac accgtccggg tcgacctcga cggcaccggc accgaccggg 44460 ccggcctcgc cgcggtgctc accgggcacg ccgacgccgg gctcaccggg atcgtgtccc 44520 tgctggccct cgacgagacc ccgtgcgggt ccgccccgca ggacgccgca tccggtgcgg 44580 acgcggtgcc cggtgtggac gcggtgcccg ccgggctcgc cgcgaccgcg gcactcgccg 44640 cggcgctcgc cgacaccggc gtcaccaccc gcgtgcacgc cgtgacccgc ggcgccgtgg 44700 caccggcggg cgacggcccc gccgcccccg tgcaggccgc ggtctggggg ctcggacggg 44760 tcgccgcgct cgagctgccc cgccggtggg gtggtctggt cgacctgccc gccgagctcg 44820 acgccgccac cctgcgcagg ctgcccgcgg tgctggcggg cgaggaggac caagtcgcgc 44880 tgcgcgccac cggtgcccac ggccgccgga tgaccccggc gccgacccgc cccgcggacg 44940 gccccgacac cgcggacacc cccgcctgga ccccgtccgg cacggtgctg atcaccgggg 45000 gcaccggtgc gctgggcggc cacgtcgcgc ggcggctggc cgccgacggc gcggagcacc 45060 tggtgctgct gggccgacgt ggtccggacg cgccgggcgt ggacgccttg cgtgccgaac 45120 tggaggcctc cggcgccgcg gtcacggtgc tcgcctgcga cgcggccgac cgcgcacagc 45180 tgcaggcggc gctggccgcg atcccggccg atcggccgct gaccggcgtc gtgcacgccg 45240 ccggcgtcct cgacgacggc gtcctcaccg gcctgaccac cgaccgtctc gccggggtgt 45300 tccacgccaa ggtcaccccc gcgctcctgc tcgacgaact gacccgcgac ctcgacctcg 45360 acgcgttcgt cctgttctcc tcggtggccg gcagcgtcgg caaccccggc caggccggct 45420 acgcggccgc gaacgccgcc ctcgacgcgc tcgcggcgcg ccgggttgcc gacggccgac 45480 cggccaccgc tgtggcctgg ggcgcgtggg cgggtgccgg catggccgcc gcgcacaccg 45540 gcaccggcac cgtcccggac gggcagctgg accccgacct cgccgtgcgg gcgctggtcc 45600 gcgcggtcgc cgagccggcc ccgaccctgg tggtcgccga cctcacccac ccgcgcctgc 45660 tggaggcgct gctctcggtg cgccccagcc cactgctcgc cgacctgccc gcggcacggg 45720 acatcgcccg ggccgcgcag gagacccgcc gccgccgcga cgacgtcgcc ggcgggttgg 45780 gtgcccggct ggccgcggcc ggaccggagg agcgccgggc cgtcctgctc gacctggtgc 45840 gcgacaccgc cgccggggta ctgggacaca ccggcccgca ggcgatccgc cccgggaaac 45900 cgttcggcga cctgggcttc gactcgctca ccgcggtgga gctcagcaac gcgctgcccg 45960 ccgcgaccgg gctgtccctg cccgcgagcc tggtcttcga ccaccccacc ccccgggtgc 46020 tggccgcaca cctggtcacc gagctcaccg gtgacaccgg cggcgcggac ggcgccgggc 46080 ccgtcgagca caccgcggtc gacggcgacg acccggtcgt cgtcgtcgcc acggcctgcc 46140 ggttccccgg cggcgtcagc acgcccgagg agttctggca gctgctcgcc gacggcggcg 46200 acggcatcac cggcttcccc accgaccgcg gctgggacct cgacgtcctc gccggtgacg 46260 ggcagggccg cagcgccacc cgggagggcg gcttcctgca cgacgccgcc gggttcgacc 46320 ccgccttctt cgacatctcg ccccgcgagg ccgtcgccat ggacccgcag cagcggctgc 46380 tgctggagac cacctgggag gcgttcgaac gcaccgggac cgacccggcc cggctgcgcg 46440 gcagccgcac cggcgtgttc gtcggcacca acgggcagga ctacgcgaac ctgctgctgc 46500 gctccccgga cgacgtcgag ggccacgccg gcaccggcct cgccgcgagc gtcatctccg 46560 gccggctcgc ctacgcgttc ggactggagg ggcccgcggt caccgtcgac accgcgtgct 46620 cgtcgtcgct ggtcgcggtg cactgggcgg cccaggcgct gcgcgcgggg gagtgcgacg 46680 ccgcgctcgc cggtggcgtc accgtcatgt cgacctccac cagcttcgcc gggttcaccc 46740 ggcagggcgg cctcgccccc gacgggcggt gcaaggcgtt ctccgatgac gccgacggca 46800 ccggctggtc cgagggcgtc ggcgtgctgg tgctggagcg gcagtcgacc gccctcgccc 46860 gcgggcacga catcctcgcc gtcgtccgcg gctcggcggt caactccgac ggcgcctcga 46920 acggcctcac cgcgcccaac gggccgtccc agcagcgggt catccgtcag gcgctcgcct 46980 ccggcgggct gaccccggcc gacgtcgacg ccgtcgaggc gcacggcacc ggcaccgtgc 47040 tcggcgaccc gatcgaggcc caggcgctgc tcgccgccta cggccgggac cgggagcacc 47100 cgctgctgct cggctcggtg aagtccaaca tcggccacac ccaggccgcg gccggcgccg 47160 ccggactgat caagatgatc ctcgcgctgc agcacggcac gctgccgcgc acgctccacg 47220 tcaccgaccc gtcgagccgg gtcgactgga ccgccggtgc ggtcgagctg gtcaccgagc 47280 aggtgccgtg gccggagacg ggccgtgccc gccgggccgg ggtctcgtcg ttcgggatca 47340 gcggcaccaa cgcccacgtc gtgctggagc aggccccgca gctgccggag cccacgcggg 47400 caccggcgcc cgtggtcacc ccgtgggtgg tctccgcccg gtcggcggcc gcgctcgacg 47460 cccagctcga ccggctccgc gccgcgaccg gcggtccgga cctcaccacc gccgccgagg 47520 tcggacacgc gctggccgtc ggccggtcgc tgttcgagca ccgtgccgtg ctgctcgccg 47580 acgccgacgg cgtcaccgag gtcgcccgcg gcgaggcggc cgaacggtcc accgcgttcc 47640 tgttctccgg gcagggtgcc cagcgcctcg gcatgggccg cgcgctgcac gcccgccacc 47700 cggtgttcgc cgacgcgctg gacacgacgc tggcccacct ggacccgacg gtgcgcgccg 47760 tgctgtgggg cgaggacccc accgcgctcg acgacaccgg tgtcacccag cccgcgctgt 47820 tcgcggtcga ggtcgcgctg ttccggctgc tggagtcgtg gggcgtgacc tcggacgccg 47880 tcgccgggca ctcggtcggt gaggtcgccg ccgcgcacgt ggccggggtg ttcaccctcg 47940 acgaggcctg cacgctcgtc accgccaggg cccgtctgat ggcggcgctg ccggtcggcg 48000 gcgcgatggt cgccgtcgag gcggaccccg gcgacgtcac accactgctg accggcggcg 48060 tggccgtcgc cgcggtgaac ggcccgtccg cggtggtcct ctccgggccc acggacgagg 48120 tctccgccgt cgcggacgcg ctcgccgccc gcggctgccg cacgcgggcg ctgcgggtca 48180 gccacgcctt ccactcgccg ctgatggagc cgatgctcga cgggttccgt gacgtcgtcg 48240 ccggtctgaa ccccgtcgag ccgcggatcc ccgtggtctc gacggtgacc ggcgccgcgg 48300 ccaccaccga gctgtgcgac ccgcagcact gggtgcgggg cgtgcgcgac accgtgcgct 48360 tcgccgacgc ggtgcggaca ctgaccggga gcgggatcac cgcgttcctc gagatcggcc 48420 cggacgcggt gctgtccgcg ccgacccgcg cgtgcgtcga ggacaccgcg gtggtcgtcc 48 480 cggccctgcg cggcccggac accgaggagc gcgcgctgct caccgcgctg ggcaggctgc 48540 acgtcgccgg gaccggggtg gactggacgg cggtcctcgc cgggaccgcg gccggccggg 48600 tggcgctccc gacctacccc ttccagcggg agcggttctg gcccacggtc gccgccacgg 48660 cccccgccga cgcgggcggc ctcggcctgc gcgccggcgg acacccgctg ctcggcgccg 48720 cgaccaccgt cgccgggtcc ggcgagatcc tgctgaccgg ccgtctcacg cccaccctcg 48780 tggacccggc cgccggcgac ctgcccgcgc tgcccgcggc ggtgctcgcc gagctcgccg 48840 tccgcgcggg cgacgaggcc ggcgtgacga ccgtcgagga gctgacgatc accgcccccc 48900 tgggcagcgg gacggcgcag ctgctgcagg tccgcgtcgg ggaaccggac gacgacggcc 48960 gccgcacgct ggccgtgcac gcccgcgccg ccgacgaccc ggacggcccg tggacccggc 49020 acgccggcgg cacgctgtcc gcggccgccg cgccggtgcc cgagccggag cccgtgtggc 49080 ccccgcaggg cgccgaggcg ctgaccgggc tgcccgacac cgtcggaccg gtgcgggtcc 49140 gcggggggtg gcggcacgac ggtgacctgc tcgccgagct cgagctcacc gagcagcccg 49200 ccggttacac cctgcacccg gcgctgctcg acgtcgccgt ccggttcggc gccgccaccg 49260 acgtcgccga cctcaccgcg ctgcggggcc tcaccctgca cgcctcggac gccaccgtgc 49320 tgcgggtccg cctcaccgac cgcggcgacg gcacccgggc actcgccgca tgggacgcgc 49380 agggcgcacc ggtcctgacc gccggtgagc tgaccctggc cgagcccacc gccgcggacg 49440 gcccggccgc gtccaccgac gcggtcctgc tcaccctcga ctggaccgcc gcgcccgcgg 49500 tggaccgggc gggcacggcc gggtggggga tcctcggtga cgcgcccgcc gagctcggcg 49560 ccgccctggc cgcgtccggc ccgaccccgc cggtccgcgc cggctcggtc ggcgcgctcc 49620 tcgactccgg cgacccgctg cccccggtcg tcctcgcgcc gatcaccggg gcgccgatca 49680 ccggggcgcc gatcaccggg gcgccgatca ccggggcgcc gggagccggg acaccggaca 49740 tggggggcgc ggacctcccc ggccggaccc gcgccaccac cggtgccgtg ctggagctgc 49800 tgcagcgctg gtccggtgac tcccgcacgg cgggctcccg gctcgtcgtc gtcacccggg 49860 gtgcggtcgc caccggaccg gccgaggacg tccacgacct cggcgccgcc ccggtgtggg 49920 ggctcgtacg ctccgcccag tcggaggtcc cgggcagcat gctgctgctc gacctcgacc 49980 cggccgaccc cggcgccggt cccgacgccg cactggcggc actgcccggc ctggccgcgg 50040 ccggggagac ccaggccgcc gtgcgcggcg gcgccctcac cgtcgcccgg ctgacccggg 50 100 ccaccccgga cgcacccgca ccggcggcgg cgtgggcccc ggacggcacc gtcctggtca 50160 ccggcggcac cggaggcctg ggcgccctgc tcgcccggca cctggtcacc acacgcggtg 50220 tgcggcacct gctgctcgcc ggccgtcggg gcccggacgc gcccggcgcg gcgcagctgc 50280 gtgccgagct cgccgcgctc ggagccgagg tcaccctcgc ggcctgcgac gtcgccgacc 50340 cggcggcggt cgcggagctg gtcggcgccg tgccggccgc ccacccgctg accgcggtgg 50400 tgcacaccgc aggggtactc gacgacgcca ccgtcggctc gctggacgcc gcccggatgg 50460 accgggtact gcggccgaag gccgacgcgg cgtggcacct gcacgaggcc acccgggacc 50520 tgccgctggc cgcgttcgtc ctgtactcct cggtcgccgg gatcaccggc ggccccggcc 50580 agggcaacta cgcggccgcc aacaccctgc tcgacgcgct cgccgcgcat cgcgcggcac 50640 acggcctgcc cgggctctcg ctggcctggg ggccgtggtc ggccgacgcc ggcatgaccg 50700 gcaccctcga cgccgccgaa cgggagcggc acgaacggtc cgggatgccg ccgctgcagc 50760 ccgcgcaggg cctcgccctg ttcgacaccg ccctggcccg gggcgaccgg ttcgccgtcg 50820 ccgcccggtt cgccgccggg gccgggaccg ccgtcgacga cgtcccggcc gtgctccgcg 50880 ccctggtgcg cagcatgcgc cggaccgcgg ccgccaccga gggcgcgggc ggtctgctcc 50940 gcaggctcgc cgggatggag cccggcgccc ggcacgccga gctgctggcg ctcgtccgcg 51000 ccgagaccgc ggcggtgctc gggcacaccg gtgccgaggc ggtccccgcc gaccggcact 51060 tcagccggct cgggttcgac tcgctcaccg gtctggagct gcggatgcgg ctggcggccg 51120 ccaccgggtc caggctcccg gcaacgctgg tgttcgacca ccccaccccg gccgaggtgg 51180 cccgccacct cgacgaggag gtgctcggct cggcggaccg gggggcgtcc tccccgctgg 51240 ccgagctgga ccggctggag gccgcgctgt cccccgacgg tgccgacgcc gagacccgta 51300 gcggggtcgc ccgccggctg cgccgactgc tggagcagtg ggacggggcc cgcaccgacg 51360 gcgccgaccc cgacggccgc accgccgtcg acgaacgcct cgaatcggcg agcaccgagc 51420 aggtcctcgc cttcatcgac aacgaactcg gccggtcgtc ggcgcgctga ccccggaccc 51480 ccacgaacga gagaggcgga caggaccatg cccgacgaac agaagctcgt cgactacctg 51540 aagtgggtca cggccgatct gcacgacacc cggcgacgac tggccgaggc ggaggcagcc 51600 cggcacgagc cggtcgcgat cgtcgggatg gcctgccggt tccccggcgg ggtgcgctcc 51660 ccggaagacc tgtgggagct gctcaccgcc ggccgcgacg gcatcggccc gttccccgac 51720 gaccgcggct gggacctcga cgcgctggcc ggcgacggtc ccgcggcgag cgccacccag 51780 cggggcgggt tcctgcccgg cgccgccgag ttcgaccccg cgttcttcga catctccccg 51840 cgcgaggcgc tcgcgatgga cccgcagcag cggctgctgc tggagaccgc gtgggaggcg 51900 ttcgaacggt ccgggatcga ccccgcgggg ctgcgcggca gccgcaccgg ggtcttcgtc 51960 ggcaccaacg gccaggacta cacccacctc gtcctcgcct ccgccgacga catgggcggc 52020 tacgccggca acggcctcgc cgccagcgtg ctgtccggcc gggtgtcgtt cgccctcggg 52080 ctgcagggcc ccgccgtcac cctggacacg gcgtgctcgt cggcgctggt ggggatgcac 52140 ctcgccgccc aggccgtgcg cagcggcgag tgcggtctgg cgctcgccgg tggcgtgacc 52200 gtgatgacca ccccggcgaa cttctccggg ttcagcctgc acggcggcct cgccccggac 52260 ggacgctgca aggccttcgc cgacggcgcc gacggcaccg gctggtccga ggggatcggc 52320 ctgctcgtgg tcgagaagct cgccgacgcc cgcgcgcacg ggcacccggt gctcgccgtg 52380 ctccgcggct ccgcggtgaa ctccgacggc gcgtcgaacg ggctcagcgc cccgaacggg 52440 ccggcccagc agcgggtgat ccgccaggcg ctggccagcg gcgggctgtc cccggccgac 52500 gtcgacgccg tcgaggcgca cggcaccggc accgcgctcg gcgacccgat cgaggcccag 52560 gccctgctcg ccacctacgg cgccgaccgt gaccccgacc ggccgctgct gctcggctcg 52620 gtgaagtcca acctcggcca cacccaggcc gccgccggtg ccgccggggt gatccggacc 52680 gtgctggcgc tgcagcatcg gacgctgccc cgcaccctgc acgtcgacgc gccgtcgagc 52740 cacgtcgact ggtccgcggg ggcggtccgg ctgctcaccg ggcagaccgc gtggccggac 52800 accgggcgtg cgcggcgtgc aggggtgtcg tcgttcggga tcagcggcac caacgcccac 52860 gtcgtgctgg aacaggctcc caccgacccg gcggagccca cggggtccac ggtccccacc 52920 gggcccgcgg tgcgcccgca ggccgtcgcc tggccggtct cggcgcgctc cgccacggca 52980 ctggacgccc agctggaacg ggtccgcgcc ctcgcggcgg cgcccgtccc ggccgacgtc 53040 ggccaggcgc tggccaccac ccgcaccccg ttcgcgcacc gcgcgctgct cgtccacacc 53100 ggcgacgggc tcaccgaggc cgcccgcgac gtcgtcccca ccggtgaccg cggcgggctc 53160 gccgtcctgt tctccgggca gggctcgcag cggctcggcg caggctgcga gctgcacgcc 53220 cggttcgcgg tgttcgcggc ggcgttcgac gagaccgtcg ccctgctcga cgcccggctc 53280 ggtgcgtcgc tgcgcgaggt cgtctggggc agcgaccggg ccgcgctcga cgacacccgg 53340 ttcacccagc ccgcgttgtt cgcgaccgag gtcgcgctcc accggctcgt cgagtcctgg 53400 ggggtgcgcc ccggccacgt cgggggccac tcggtcggcg agatcaccgc cgcacacgtc 53460 gccgggatcc tgtccctcga cgacgcctgc accctcgtcg ccgcccgcgc ccggctcatg 53520 gccgacctgc ccgcgggcgg ggcgatggtc gcgctgcagg cccgcgagga cgaggtcgcc 53580 ccgctgctgg gcgacgacgt cgcgatcgcc gccgtcaacg gtcccgacgc ggtcgtggtc 53640 tcgggcgacg ccgacgccgt cgccgccgtc gcggcccggt tcgaggaccg gggccggcgc 53700 atccgcaccc tgtccgtcag ccacgccttc cactcgccgc tgatcgaccc gatgctcgcc 53760 gagttcgccc gggtcgtcga cggcctcacc ttcgccgagc cacggatccc cgtcgtctcg 53820 aacctgaccg gcgaggtgtc cggcgagctc accgaccccg gctactgggt gcggcacgcc 53880 cgcggcgccg tccgcttcgg cgacggggtc gcggccctgg ccggcctggg cgtgcggacc 53940 ttcctcgagc tcggcccgga cgccgtgctg tccgcgctgg tcgccgagaa cgcccccggc 54000 gccgtcgccg tccccgcact gcggcgcggc gcgggggagg aggccaccct gctcgtcgcg 54060 gccggtgcgc tgtggacccg cgggaccgac gtcgactggg cggccgtcgc cgaggggacc 54120 accaccccgg gcgccgcccc ggtcacgctg cccacctacg ccttcgaccg cgagcggtac 54180 tggccgacgc tgcgtgccgc caccggcgat gccgccgggc tcggcctgac cgcggccggg 54240 cacccgctgc tcggcgccgc cgtcgtcctc gccgacgccg accgcaccgt cctcaccgga 54300 cggctctccc cccgtaccca gccgtggctc gggccggaac ggaccgacgg ccgcgtcgac 54360 gtgcccggcg cggtgttcgc cgagctcgcg atccgcgccg gcgaccaggt cggtgccccc 54420 cacatcgccg agctcgacct cctcgcgccg ctggccgtcg gtcgcgacgg cgccgtcctg 54480 caggtcggcg tcggcgcccc cggtgaccgc ggccgccggg acctcaccgt gcacgcccgg 54540 tcctccgacg acgctccgtg gaccctgcac gcccgcggcg tcctcgcgca cgaggccgac 54600 cgggtcggca cgaccgaccc gggggagtgg ccaccccgcg acgcccgcgc ggtgccggcc 54660 cgggacaccg ggccggacca ggtgtgggtg cgggacgggg aggtcctcgc cgaggtcacc 54720 ctgcccaccg gtgccgccgc cgacggctac ggcctgcacc cggcgctgct gggcgccgcg 54780 ctggccaccg catccgcgct cgacggtggc ccgaccgcca ccgcggaccc cggggcgggc 54840 ccggcgcgca tcgagggcct gaccctgcac gccaccggtg ccaccacgct gcgcgtgcgg 54900 ctcaccggga ccggcaccgg cacgttcggc ctcgtcgcca ccgaccccac cggggcaccg 54960 gtgctcaccg ccgacgccgt gcacaccggc acgggcgaca cgcaggcacc cgccgcgacc 55020 gggcagggcg ggctgttcgg cctgcactgg acaccggtcg agctcggtga ccgcgccgcg 55080 ggtacccgct gggccgtcgt cggcgacgac gagctcgacc tcggctacgc gatgcaccgc 55140 gccgacgaga ccgtcagcgc ctacgccgag tccctgggcg gcgccgtcgg cgacaccggt 55200 ctcgcccccg acgtcttcct catccccgtc gtcggcgacc ccgacggcgg tgcggccgcc 55260 gtgcacaccc tcaccacccg ggtgctgggc ctgctgcagg agtggctcgc cgagccgcgc 55320 ctcgccgacg cgcgcctggt cgtcgtcacc cggggggcgg tcgccgccga cggcgagacc 55380 gtcaccgacc cggcggccgc cgccgtctgg ggtctggtgc gtgccgcgca gaccgagaac 55440 ccgggccgga tccggctggt cgacctcgac gacacgttcc gctcggccgg ggtcctgccg 55500 cacctgctgc tgctcgacga gcagcagctg ctggtccgcg agcacgaggt ccgcgccgcc 55560 cgcctggccc ggctgccgga gatcgcgccg gacaccgtgc cggacaccgc gcgtacggcg 55620 gcggactggg accccgacgg caccgtcctg gtcaccggcg gcaccggcgg gctcggcgcg 55680 ctgctcgccc ggcacctcgt cacgaccggc cgcacccgga acctgctgct ggccagccgc 55740 cgcggcccgg acgcccccgg tgccgccgag ctgtgcgagg agctgaccga gctcggcgcc 55800 gccgtcgccg tcaccgcgtg cgacgccggg gaccccgacg ccgtcgccgc gctggtcggc 55860 tccgtcccgg ccgggcaccc gctgaccgcg gtcgtgcaca ccgccggcgt cctcgacgac 55920 ggcctgaccg gctcgctcac cccggagcgc ctcgccgggg tgctgcgccc caagctcgac 55980 gcggcgtggc acctgcacgc cgcgacccgc gagctgccgc tggccggttt cgtcctgtac 56040 tcgtcggtgt cggggatcct cggcagcgcc gggcaggcca actacgccgc cgccaacgcc 56 100 ggactcgacg gcctcgccgg gtaccgggcc gggctcggcc tgcccgcggt gtcgctgggc 56160 tggggcccgt ggggccgcgg gagcggcatg accgagcagg tcaccgacgc cgacctcgac 56220 cggatggccc gcggcggcct gcccgccctc gacgccgccg acggcctcgc cctgttcgac 56 280 gccgcactcg cccgcccgga accggtcgtc gtcccgaccc ggatcaacgt cgccggtctc 56340 gccgtgcagc aggcgctgcc cgcgctgtgg cgcgacctgg tgccccgcac ccgccgcacc 56400 gccgccgtcg ccggctcctc gccggtcacg gtgcgcgaac ggctgcaccg cctcgacgcc 56460 gccggccggg aggcactgct cgtcgagctc gtcaccggct acacggccgg actgctcggg 56520 cacgaggacg cggcggcggt cgacccggag cgcggcttcc tcgagctggg cttcgactcg 56580 ctcgtcgcgg tcgggctgcg caaccagctc ggcgaggtcc tcgggctgcg gctggccggg 56640 tcgatcgtct tcgacagcac caccccggtg aagctcgccc gccggctgca cgagctcgtc 56700 gagcaggccc cggcccccgg cgcctcgccc gccgtcgtcg ccgggcggcc cgcacagccc 56760 ggcgaggaga ccctcgtcgg cctgttccac gccgccgtcc gcggcggcaa gctggtcgag 56820 gcgatgcgga tgctcaaggc cgcggcgaac acccgaccga tgttcgagtc cccggccgag 56880 ctggaggagc tgtccgagcc ggtcacgctc gccgaggggc ccgccgcccc ccggctgatc 56940 ttcgtcagcg cccccggcgc caccggcggg gtgcaccagt acgcccgcat cgccgcgcac 57000 ttccgcggca gccggcacgt gtccgcgctg ccgctgatgg gcttcgcacc cggcgagctg 57060 ctgcctgcca ccagcgaggc cgcggcccgg atcgtcgccg agagcgtgct gctcgccagt 57120 gacggcgagc cgttcgtgat ggtcgggcac tccaccggcg ggtcgctggc ctacctggcc 57180 gcaggggtgc tggaggagac ctggggggtg cggcccgagg cggtggtgct gctcgacacc 57240 gcctcgatcc ggtgggacgc ggccgagggc aacgacctgg accgcacgac ccggttctac 57300 ctggccgaca tcgactcgcc gtcggtcacc ctcaacagcg cgcggatgtc ggcgatggcg 57360 cactggttca tgacgatgac cgagatcgac tcgccgccga cgacggcgcc gacgctgctg 57420 gtgcgcgccg cgcgcgacgt cgagggcttc atcctggaca cctccgccgt gcccgccgac 57 480 accgtggtcg acatcgacgc cgaccacctg tcgctggcca tggagcactc cgcgctcacc 57540 gccgacgcga tcgagacctg gctcgccgag ctgcccaccc cgacgacgga ggacgcgtca 57600 tgaccagccc gacgacctgc ccggtcaccg gcggcgggcc cccgccgtcc ctggagggcc 57660 agaccccgcc ggtgctgcgg ctgagcccgc tgctgcggga gctgcagcag caggcacccg 57720 tgtgccgggt ccggaccccc accggcgacg aggcctggct ggtcacccgc tacgccgagc 57780 tgaaagcact gctgcacgac gagcgcctcg gccgcgcgca cgccgatccg gcgaacgcgc 57840 cgcggtacgt gcgcaacccg ttcctggacc tgttggtcgt cgacgacgcc cagcaggccc 57900 gggacttgca caccgagatg cggcgcctgc tcaccccgca gttctccgcg cgccgggtgc 57960 tgggcctggc gcccacggtg tccgcggtcg ccgagcaggt gctcgacggg ttcgtcgccg 58020 cgggcaaccc cggcgacctg cacggcgggt tctccatgct cgctactcgc atgacggtgc 58080 tgtgcgaact catcgggatc ccgccgcagg accgacccga gactggtgcg tgcaccatca 58140 tgacgatggg ggaggtggac gacgtcgagc gagtcgccac ggtccaggcc gagctgttcg 58200 ggctgctgtc cgccgtcccc cggcgcaagc gggccgagcc caccgacgac gtcgtgtccc 58260 ggctgttcgc gcaggtgccc gacgagcgga tcggcccgat cgccgccggt gtgctgttag 58320 ccgggctcga cagcgtcccc agccacgtcg acctgggcgt actgctgttc gcgacccacc 58380 ccgaccagct ggcggccgcg ctcgccgacg agcgcaccat gcgcgagggc gtcgaggaga 58440 tcctgcgctg cgccaaggcg ggcggatcgg tgctgccccg ctatgccacc gacgacgtcg 58500 agatcggtgg cgtcaccctg cgcaccggcg acctggtgct gctggacttc accctggtca 58560 acttcgacac ccaggtgttc gacgagccgg aggtgttcga catccgccgg gagtcgaacc 58620 cgcacctgac cttcggacac ggcatgtggc actgcatcgg cgcaccgctg gcccggatgg 58680 cgctgcggac cgccttcacc cggctgttca cccggctgcc ggacctgcgc ccggcccgtc 58740 cggtgcagga gatgcgccgc ggctccgagg gactgtccgg tggtctgacg gagctgcccg 58800 tcacctggtg acggccgggg cacacccgcc ccggcacgcg gtcacgatgg cgcgggtgtg 58860 ctcagcccca ggtcaccggg agctcgtgca gaccgaacaa cacgccgtcg tacttcacgc 58920 gcaggtcatc ggcgggcacc gccaggcgca gcgtcgggat ccggtcgaac agcgtgcggt 58980 aggcgatctc catctccagc cgcaccaggt tctggcccag gcactggtgc acgccgtagc 59040 cgaaggccac gtgcgagcgc gcggagcgtt ccgggtcgaa cgcgccggcg ccgtcgaagg 59100 cgtcgtcgtc gtggttggcg gcggccagca gcggcaggat gccctcgccc gcgcggatcg 59160 tgcgcccgcc gatctcgacg tcggccagcg cgacccggaa cgcgaccagg tcggccaccg 59220 agtagtagcg cagcagctcc tcgacgacgc ggtcgtcgcc gatccactgc gggttcgtca 59280 gtagttggac gatgccgagg ccgatgttgt tcgccgtcgt ctcgtgaccg gcgatcagca 59340 gcagcatggc cacaccggag agctcctggc gcgacaacgt cccggtcgcg gcgagccggc 59400 tgatcaggtc ggtgccgggg cgccgctcct tgatccggat gagccggccc aggtagcgca 59460 gcagggccgc ggtcgccgcg tcgcgttcct cgtcgctgga gctgagagtg accaggacgc 59520 gggtcttcgc ctcgaagaag tcgcggtcgg cccgcgggac gccgagcatg cccgcgatca 59580 ccagggacgg caccggcagc gcgaagtcct cgatcaggtc ggcggcgccg tccttcgcga 59640 ggatcgcctc gatccggtcg tcgacgatct gctggatctc cgggcgcagc gcgcgcacct 59700 tgcggacggt gaactcgggg atcagggtcc ggcggaaccg gtcgtgctcc ggcgggtcca 59760 tcgacacgaa ccagccgggc acctcgtccg cggacggggc cccaccggtc cgggccgcct 59820 tcgggaagcc cggtcgggag gggtcggcgc tgatccgcgg gtcggtgagc acggcacgca 59880 cgtcggcgtg ccgggtgacc agccagaccg ggccgctggg cagctcggac cggacgggct 59940 caccgccgtc gcggtagtcg gcgtactccg ggggcgggaa cggtcttccc ggacggcgca 60000 gcgggaacgc caccgggcag gtggcggcac ctgccccggc cccggtgacg gggcagccgg 60060 tggcggtgtc cgacggcgtg gacctcgcgg tgccggtgct catgccactc cgtagaacgc 60120 gcggacctgc ccggtgatga actcctggtc ctcggcggtc agcccggtgt gggtggggag 60180 gtagaagccg tcggcagcca gccgcgatgc gttgagcgtc ggccagaccg ggtcgaggta 60240 catcggctgg cggctcatcg gcttgaagaa cacccgggtg tcgatgcccc gggcggcgag 60 300 gtgggcgagg agctcgtcgc ggcgctcggc gcgcaggtcg tacatccaga gcacgtcccg 60360 cggtggcatc agcgtgatgc cggggacgtc gcggagggcg tcgtcgtagc gcttctcgat 60420 gtcgcgccgg gtcgccagga tgccctcgag ctgctcggtc tgggcgagcg cgacggcggc 60480 ctgcatgttg gtcatgcggt agttgtaggc gagcttcttg tgcaggaagc tgtggtcgcg 60540 ggtgaacgcc atcgcgcgca ggtgcgccat ctgctcggcc aggtgcgggt cgcgggtcac 60600 gcagatcccg ccctcgcccg cagtgatgat cttgttggcg aacagcgaga agcaggcgat 60660 gtccccggtg ggcagcacgc cgtgcgcctc ggcggagtcc tcgacgaccc gcaggttgta 60720 ctcgtaggcg agctccagga tcggctccat gtcgcaccgg cggccgtaga cgtgcaccgg 60780 catgatcacc ctggtgcgcg gggtgatctt ctcctcgagc agcgtgacgt cgatgttcag 60840 gtcgtcgccg cagtcgacga acaccggtgt cgcgccggtg taggtcaccg cccacgccga 60900 ggcgatcatc gtgaactccg ggacgatcac ctcgtcgccc gggccgacgc ccagggcgcg 60960 cagggcgagg gtcagcgccg tcgtcccgga cgagcaggcg accccgtgcg ggacgccgtt 61020 ccaggcggcg aacgcctcct cgaaccgtgc gatgtagggg ccctgcgagg agatccagcc 61080 gccgccgacg gcgtcggtga cgtagtcgag ctcgtggccg tcgagccacg gcttggacac 61140 cggttgggtg aaggacatcg tgactccctg gttcggtggg ggcgcgtggt caggcggtcc 61200 gggcggccgg ggcgtcggtc ccggcgagca cgggcaggcg caggatcagg tcggcggcgg 61260 cggcgcgccc gcccgcctcg tgcagcagcc gacccatgcg cgcggcacgc tcggtgaagg 61320 ccggggtctc gaggacccgg gtgaccttgt cgaggacgtc gtcggtgtcg acggtctccg 61380 ggtggtcgac ggtgaggctg accccgaagt cctggccgcg gatcgcctgg tcgtcacagt 61440 ccacccagag cgggcggacc accagcggct tcccgaagta gaggccctcg tggtagccgt 61500 tgccgccggc gtgggtgaag aacaccttca cgctcgggtg ggccagcacg tcgagctggg 61560 agggcaccca gctctcgatc cgcaggcccg cgggcagctc ggtggcgggt ggcagcatct 61620 cctgctgctc gcgcggcagc ttccacagca cctggtgacc ccgggcgtcg agccggcgtg 61680 ccacctcgac cagcgacgcg acctggggcc gggtcagccg ggtgatcgtg ccgaatccca 61740 tgtagaccac cgacgactgc gcgtcgagcc agtcggtgag ctcaccaccg tcggcgacct 61800 ggggcagcgg cggcaccatc gtgccgacga gacgcatcct ctcgggcagc tcgaacgggt 61860 agtccagctc cggcaccgag tagcagagca cctgctcggc gtggtcgatg cgggccatca 61920 tctgccgggc ctcgggcgcg atgccgagct cggcccgcac ggcgtcgtcg cgctcgacga 61980 ccttgcgggt ctccttggtg acgaacatgc cgagcgtccg gatccggaac agctggttgg 62040 cgatcttctg gcgcagcgtc atggtggccg gcagcccgga gtgcggcacc gggaacccgg 62100 acggcgtgta ggacctcgcg aacgggacgt gcgaggtgag cacgttgctg gggacgaacg 62160 gcacgccgag cacgaacggg atccccttgg tgatcgcgag ctcgtagccg tactggcaca 62220 tgctctcgat caccatcagg gccgggcgga cctcgtcgac gacgcgttcg agcgcccggt 62280 acttctcgat ccgggactcg ggggcgaagg agtgccggat gaccgcggcg tgcgcccgga 62340 accggtcccg ctgggtcacc gcggcgtagg tctcgtcgtc ccaggtcacc gccgacatct 62400 ccgacacggt gtcgccgagc gaggcgaagg tgacggggct gcccgtgctc gcgcccgcga 62460 cgtcgtcgcg ggccttttcg tcggcggcga agtacaggtc cccgacctcg cgccgggaca 62520 gttccccggc gaggaccagg agcggattga gcagtccgct ctccgcatag ctgacgaaca 62580 ggatcggccg ccgattcgcg cccatgggta gacaccctct ccgactgtga cgggccgggt 62640 gacccgtcgc gtggcgcacc gcggcgcggt gcagcgatca ggtagttgat cccacggccg 62700 acgccgggga atccctagtc ctcggtcccg gcccgccgca ttcattaggg aaaaccacag 62760 ccgcgccgac cgtacggtcg gcgccacatc gagacgaccg cattcgtgtg caggggtgag 62820 gtatgacggc aggacacggc agcgacccgg tggtggtcgt cggaatggcg tgccgctatc 62880 cgggtggtgt gcgcgacgcc gacggcctct gggacctgct gtgctcggac cgggagacgg 62940 cctccgggtt cccggacgac cggggctggg acctcgacgc cctgcacggc gacgggccgg 63000 ggcgctgcgc gacccgcact gccgggttcc tcgacggcgc cggggacttc gacgcggcct 63060 tcttcgggat gtcgccgcgc gaagccgtct ccaccgaccc gcagcagcgc ctcgtgctcg 63120 agaccgcctg ggaggcggtc gagcacgccg ggatcgaccc gtcgtcgctg cgcggcaccc 63180 ggaccggggt gttcgtcggg gccggtgggc aggactacgc gggcgtcgtc cagaactcgc 63240 ccgacgacct cgccggacac gccctcaccg gcctgatccc cggtctcacc tccggccggc 63300 tcgcccacct gctcgggctg gaggggcccg cgctgaccgt ggacacgacg tcgtcgtcgt 63360 cgctggtggc gctgcacctc gcgatccggt cgctggacgc gggggagtgc accgccgcgc 63420 tggccggcgg ggtgtgcgtg atgtccaccc cggccgcgct ggtcgggcac tcccgccagg 63480 gcggcctggc ccccgacgga cgcgccaagg tcttcgccga cgacgccgac ggcaccgcct 63540 gggcggaggg ggtcggcgtc gtcctgctca agcgcctctc ccacgcccgc gcggacggtg 63600 acccggtcct cgctgtgctg cgcggctcgg cgctcaccgc cgacggcgcc accgacggcc 63660 tgaccgcgcc gagcggggcc gcgcaggagc ggatgatccg cgacgcgctc gctgacgcgg 63720 gtctgaccgc ggccgaggtc gacgccgtcg aggcgcacgg caccggcacc ccggtcggcg 63780 acccggtgga ggcgcgcgcc ctgctcgcca cctacgggca ggaccgggac ccgggccgcc 63840 cgctgtgggt cggctcgctg aaatcggtgg tcgggcacgc ccaggccgcg gccggggtcg 63900 ccgggctgat cgcgaccgtg caggccctgc gccacgagct gctgcccgcg acccggcacg 63960 ccgtcacccc cagcacccgg gtcgactggt cggccggggc ggtcgcgctg cgtaccgcgc 64020 cggtgccgtg gccgcgcggg ggccgcccgc gccgcgcggg ggtgtcgtcg ttcgggatca 64080 gcggcaccaa cgcgcacgtg atcgtcgagg aggccccggc cgccgacggg cccgaggccg 64140 cggaccgggg caccgcgccg ccggccgtga cgccctggcc ggtctcggcc gccgccgccc 64 200 gcgatctcga cgcccagatc gagcggctgc gggcgcacac cgccgggccc ggcgcaccgg 64260 acccgcgcga cgtcggctgg tcgctggcca ccggccgggc cgcgctgcgc caccgcgcgg 64320 tcctgctgct cggcgagcac ggccccgtcg aggtggcccg cgaacaggcg gcgccccgcc 64380 gcgccgcggt gctgttctcc ggacagggca gtcagcggct ggggaccggc cgcgcgctcg 64440 ccgcccgctt cccggtattc gcccgcgcct tcgacgacgt caccgcggcc ctcgacgccc 64500 acctcgaccg gcccgtccgc gacgtcgcct ggggcaccgg ggacgacgcc gccgccctgc 64560 tcgacgagac cggctggacc cagcccgcgc tgttcgccgt cgaggtggcg ctgttccgcc 64620 tggtcacggc gctggggctg cgtccggccg cggtcggcgg ccactccatc ggtgagatca 64680 ccgccgcgca cgtggccggg gtgctgtcgc tcgacgacgc cgcccgcctg gtcgccgccc 64740 gcgccacact catgcaggcg ctaccggccg gcggggcgat ggtcgcggtc gaggcgtccg 64800 aggacgaggt cgcgccgctg ctcggtgacc gggtcgcact ggccgcggtg aacgggcccg 64860 cctcggtggt cgtcgccggc gacgacgacg ccgtcaccgc gctcgccgcc gagctggcgg 64920 accggggccg tcgtaccagc aggctcgcgg tgtcgcacgc gttccactca ccgcggatgg 64980 agccgatgct cgaggagttc cgcggcgtcg tcgcggggct gaccttctgc gaaccgcgga 65040 tcccgctggt ctcgaacctg acgggcgagc tcggcccgac cgcggcgacc gaccccggct 65 100 actgggtgcg gcacgtgcgc gggaccgtcc ggttcgccga cggcgtccgc tccctggccg 65 160 ccgacggggt cgacgtgttc gtcgagctcg gcccgggcgg ggtgctctcg gcgatggccc 65220 gggagaccct cggaccggac accgcggcgc acgtcgtccc ggtgctgcgc cgcgaccggc 65280 cggaggagac gtcgttcgcc gtcgcgctgg gtcggctgca cgcgctcggc gtgccgatgg 65340 actggcacgc cttccacgcc gggaccggcg ctcgccgggt accgctgccc acctacgcgt 65400 tccgcggcgt gcggtactgg cccgcgccgc cgacacccgg gaaccccggt gggtcgccgg 65460 gcctgttccc ggcctccggg gcccggaccg cgacggagcc cgggcccgat gcccgggtcg 65520 tcacgaaccc ggcttccgcg accgcccggc cggatccggt acctaccggg accgcggccg 65580 gggatcccgg cgaggaccgc gcgggcaccg atcccggcgc acgctacgcc gtgatgcccc 65640 ccgcggtgcg cgagcgggcg ctgctcgacc tggtccgcac gcacaccgcc gccgtgctcg 65700 ggcaccccga cccggccgag atcggcgtcc gcagcgtgtt caaggagctg ggcctcgact 65760 cgctcgccgg ggtcgagctc tgcgaccgcc tcgcccgcga caccgggctg cggctgcccg 65820 cgacgctggt gttcggcttc ccgacccccg agctcgccgc ccgcgaggtg agcgcactgc 65880 tcggaccggg cccgcaggag ccctgcgggc ccgaactggc cgggctggag gcggcgctgg 65940 acgggttgtc cggcgacggt ccggaccgcc gggccgtcgc cgatcggctg gaggtgctgg 66000 ccgccgggct gcgccgtccc gccgcgcagc cgggaggccc gcccgacgag gacctcgact 66060 cggtgtcggt cgaccggctg ctcgacatca tcgacgaaga gttcgacacc gcatgacgaa 66120 ttcgctgcct ccgcgcgcga ccggatgacg aggacgagct gatgcaggaa tcgcaggacc 66180 agcagaacag aatcgtcgac tcgctccgcc gggtcacgac ggatctgcgc cgcgcccgcc 66240 gccgtatcga cgaattggaa tcggtcggga acgaaccggt cgcgatcgtc ggaatgggct 66300 gccggctgcc cggcggtgtc gattccccgg agtcgttgtg ggatctggtg tccgcaggcg 66360 gcgacgggat cgcggagttc ccggccgacc gcggctggga cctcgacgcg ctccggagca 66420 ccggcgacgg cggcagcgcc accgcccgcg gcgggttcct cgacgacgcc gccgggttcg 66480 acgcggcgtt cttcgggatc tccccgcgcg aggcggccgc gatggacccg cagcagcgcc 66540 tgctgctcga ggtctcctgg gaggccctcg aacgcgccgg gatcgacccc acctcgctgc 66600 gcggcagccg ggcgggcgtc ttcgtcggct cctaccactg gggcagcccg tccgccgacg 66660 ccggcaccga gctgggcgga cacgccctga ccggcaccgc cgcgagcgtc ctgtccgggc 66720 ggctgtccta caccctcggg ctcgagggcc ccgccgtcac ggtggacacg gcgtgctcgt 66780 cgtcgctggt cgcgctgcac ctggcggcgc actcgctgcg cagcggggag tcctcgctcg 66840 cggtcgtcgg cggggtgacg atcctcgccg acccgtcggt gttcgtggag ttcagcgccc 66900 agggtgggct gtcggtggac gggcgctgca aggcgttctc cgacgacgcc gacggcaccg 66960 gctgggcgga gggcgtcggc gtcctggtcg ccgagcggct ctccgacgcc cgtgcgaacg 67020 ggcaccgggt cctcgcggtc ctgcgcggtt ccgcggtgaa ccaggacggc gcctcgaacg 67080 gcctgaccgc cccgcacggg ccgtcccagg aacgcgtcat cacccaggcc ctggagcggg 67140 ccgcgctcac cgccgccgac gtcgacgccg tcgaggcgca cggcaccggc acccggctcg 67200 gcgacccgat cgaggcccag gccctgctgg ccacctacgg ccggggccgg gacaccgacc 67260 gcccgctgta cctggggtcg ctgaagtcca acatcggcca cacccaggcc gccgccggtg 67320 tcgcgggggt gatcaagatg gtgcaggccc tgcggcacag ggtgctcccg ccgacgctgc 67380 acgccggcac gccgtcgtcg cacgtcgact ggtcggccgg cacggtacgg ctgctcaccg 67440 agcgcaccgc gtggccggag accggccgcc cgcgccgggc cgcggtctcg tcgttcggga 67500 tcagcggcac caacgcccac gccgtgctgg agcaggcccc cgccgcccag gaggagcccg 67560 cgccgggcgg ggggcccacc ggtgtcctcg cctgggtcct gtccgggcac accgtgcagg 67620 cccgccgcga ccgggccgcc acgctgcacg cccggctccg cgaggacggc accgccgacc 67680 cgcacgacgt cggccacgcg ctgctgacca cccgcgcccg gcacgagcac cgggccgtcg 67740 tcgtcggtac cgcccgcgac gagctgctcg acggggtcgg cgcgttggct gcggggacac 67800 ccgccccgca cgtcgcccac ggcgtcgccg acgtcgaggg ccgcaccgtg ttcgtcttcc 67860 ccggccaggg ggcgcagtgg atcgggatgg gcgcacggct gctcgaggag tccccggtgt 67920 tcgccgcgcg tatggccgag tgcgctgcgg ccctcgaccc gatcaccggc tggtcgctgc 67980 acgacgtgct gcgccgcgcc gagggggcac cagacgccga ccgggtggac gtggtccagc 68040 cggcgtcgtt cgcggtgatg gtcgccctcg ccgcgctgtg gcgtgcccac ggggtggagc 68100 cggacgcggt cgtcggccat tcgcaggggg agatcgcggc cgccgtcgtc tccggggcgc 68160 tgtcgctgcc cgacggcgcc ggggtcgtcg cgctgcgcag ccgcgcgatc ggacggtcgc 68220 tggccgggcg gggcggcatg atgtcggtcg cgctgccggt cgacgaggtc tccggacggc 68280 tcgaggagta cgcgggccgg gtctcggtgg ccgcggtcaa cgggccccgc tcggtcgtcg 68340 tctccgggga gccgcaggcg ctcgacgagc tcggcgcggt gctcgacggc gaggggatcc 68400 gggtccgccg cgtcgcggtc gactacgcct cgcactccca ccaggtcgag gagctgcgcg 68460 cggagatcct ggagaccctc gcgggcctgt ccccgcagcc ctcggcggtg ccgctgtact 68520 ccacgctgac cggcgggctg ctggacacct cgacgatgga cgccgcgtac tggtacgaga 68580 acctccgcaa ccgcgtccgg ttcgccgacg cggtggccgc gctcaccgcg accggacacc 68640 gggtgttcgt cgagtccgcc gcgcacccgg tgctgtcccc ggccgtccag gacgcgctcg 68700 acgacgccgg catcaccggt gtcgcgggcg gcacgctgcg ccgcgaccag ggcggctacg 68760 accggttcct gctgtccgcg gcccagctgc acgtccgggg actcgacgtc gactggtcgg 68820 tcctgttcga cgacgccgcc gcggcccggg tcgacctgcc cacctacccg ttccagcacg 68880 agcggtactg gagcacccgc accgcgaccg ccgccgcccc ggacaccggt gccctggaca 68940 ccgagttctg ggacgccgtc gagcaggccg acctgcccgc cctgaccgcc gcgctcggca 69000 ccgacgagga cgcggtcacc gcgatcctgc ccggcctgtc cgcctggcgc cgctcccgcg 69060 ccgaccgcgc ggacctcgac acctggcgct accgcgtcga gtgggccgcg accccgcagc 69120 cgccccgcac cggacccacc ggcacctggc tcgtggtcac cgccgccggc accgaccccg 69180 ccgacgtcgt cggcgtcctg gagcgccacg gcgccgtggc cctgcccctc gtgctcgacg 69240 agagcaccga ccgggacgac accgaccggg aggtgctgcg cgcccggatc gcggacgcca 69300 ccgcggacgg ggacatcgcc ggtgtggtct cgctgctcgc cgccgccgag gacgacgacc 69360 cccgtcaccc ggggctcacc cgcggcctcg ccctgtcggt ggccctggtc caggcactcg 69420 gcgacgccgg gatcgacgtc gcgctctggc acctcacccg tggtgcggcc accgccgcgc 69480 ccggcgacac cgtgacccgg cccctgcaga gccaggtcgc cgcgctcggc tggaccgccg 69540 ccgtcgagca gccgcaccgc cggggcggca ccgccgacct gccggaggtc ctcgacgccc 69600 ggaccggtga ccggctcgcc gccgtcctgg ccgggcggct cggcgacgag gaccagctcg 69660 ccgtccgccc ggcgggcgtg ctcgcgcgcc gcatcgtccg cgccgatcgt ggcggccggg 69720 ccccggcccg gcgctggagc ccgcggggca ccacgctggt caccggcggg tccggcaccc 69780 tggcccccga cctggcccgc aggctggccg ccgacggtgc ggagcacgtc gtgctgctgt 69840 cccgccgcgg ccccgaggcc cccggtgcgg ccgcgctggt cgccgagctg gccgaggccg 69900 gcaccgaggc cgaggcggtg gcctgcgaca tcaccgaccg ggatgcggtc gcggccctgg 69960 tggcgcggct ggccgcgcag gggcgcacgg tcggcaccgt cctgcacacc gcggcggtga 70020 tcgggctggc cgcgatcgcc gacacgaccc tcgacgagtt cgccgaggtc gtgcacgcca 70080 aggtgaccgg tgcccggatc ctcgacgagc tgctcgacga cccggccacc gacctcgtgc 70140 tgtactcctc gacggccggc atgtggggca gcggcgtgca cgccgcctac gccgccggga 70 200 acgcgttcct gtccgcactg gccgagcagc gccgcgcgcg cgggctgcgc gccacctcgg 70260 tgcactgggg caagtggccc gacgccgacc ccgagcgcac ggaggccgac ccgcaccgga 70320 tccggcgcag cggcctggag tacctcgacc cgcagcgggc actgaccggg ctgcgctgcg 70380 tgctcgacga cgacgagacc gtcgtcggcc tgatggacgt cgactgggac gtctaccacg 70440 acgtcttcac cgccggccgg gtctcgcacc tgttcgaccg ggtcccggag gtccgggccc 70 500 ggctcaccca cgccgcggca ccggccgcgg gcccgcgcgg tgccctcgcc ggccgcctgg 70560 cgcccctgtc ggcggccgag cggacccggc tgctggtcac cctggtccgc accgaggccg 70620 ccgcggtcct cgggcacgcc tccgccgacg ccttcggcga gcgccgcgcc ttccgcgacg 70680 ccgggttcga ctcggtgacc gcggtcgacc tgcgcaaccg gctcgccgcc gcgaccggtc 70740 tgacgctgcc ctccaccctg gtcttcgacc accccagccc cgccgtgctc gccggccgcc 70800 tggaggagct cgcgctcggc gccgcggacg ggctgccgca gcccgcggcc gctccggccg 70860 gggacgacga cccgatcgcc gtgatcggga tgagctgccg ctacccgggc ggcgccgaca 70920 cccccgaggc gctgctgcag ctcgcactcg acggggtcga cgcgatcacc ggcttcccca 70980 ccggccgcgg ctgggacgcg gccgcgctgc acgaccccga ccccgaccgg cacggtcgca 71040 cctactccgt gcagggcggc ttcctgcacg acgtggccga cttcgacgcc ggcttcttcg 71100 ggatctcccc gcgcgaggcc gtcgcgatgg acccgcagca gcgcatcctg ctggagacct 71160 cgtgggaggc gttcgagcgg gccgggatcg accccacctc gctgcgcggc accagcacgg 71220 gcaccttcgt gggcgccacc taccaggact acgcgacgac cgtcgcgcac gccgcgggcg 71280 acaccgagac gcacatggtg accggcaccg ccgccagcgt gctgtccggc cgggtggcct 71340 acctgctggg cctcgagggt cccgcggtca ccctggacac ggcgtgctcg tcgtcgctgg 71400 tcgcgatgca cctggcctgc cggtcgctgc gcagcgggga gagctcgctc gccctggccg 71460 gcggcgccgc ggtgatggcg accccgcagg ccttcgtcgg gttcagccgg cagcgggcac 71520 tggccgccga cggccgctgc aagcccttct ccgaggccgc cgacggcatg accctcgccg 71580 agggcgtcgg cgtcgtcctc ctcgagcggc tgtccgacgc gcgccgcaag gggcacccgg 71640 tgctcggcgt gatccgcggc tcggcgatca actcggacgg cgcgtcgaac gggatgaccg 71700 cccccaacgg cccgtcccag cagcgggtga tccgccgggc actggccgag gcgggactga 71760 ccgccgccga cgtcgacgtc gtcgaggcgc acggcaccgg cacccggctc ggcgacccga 71820 tcgaggccca ggcgctgctc gccacctacg gccgcgaccg ggacgagccg ctgcggctgg 71880 gctcggtgaa gtccgcgatc ggacacaccc aggccgccgc gggcgtcgcc ggcgtgatca 71940 cgatgctggc cgccatgcgc gccggtgagc tgcccggcat ccagcacctc gacgcgccgt 72000 cgagccatgt cgactggtcc accggggccg tcgagctgct caccgggcgc accgcgtggc 72060 cggagaccga ccgcccccgc cgggccgggg tctcgtcgtt cggcatcagc gggaccaacg 72120 cccacgtcgt gctggaacag gcgccccccg ccgaggcgac cccgccggcc ggtgcacccg 72180 gaccggtccc gtgggtggtc tccgcccgtt cggccgacgc gctgcgcgcc caggcgggcc 72240 ggctgcgcga cgccgtggcc cgcgacccgc aggacccggc caggaccggg cacgccctgg 72300 ccaccacccg cgccgcgttc gaccaccgcg ccgtcgtcgt cggggagacc tccgacgagc 72360 tctcccgcgg cctggccgcg ctggccgacg gcacgtcggt cgccggtctg gtcaccggca 72420 ccgccgccga ggaccccgcc ggcccggtgt tcgtgttccc cgggcagggc gcccagtggt 72 480 gggggatggg ccgcgacctg ctcacgacgt cggaggcctt ccgtgccgcg gtcgacgact 72540 gcgccgccgc gctggccccg cacgtcgact ggtcgctgca cgaggtcctc accggcgacg 72600 gcgacccggc gctgctggag cgcgtggacg tggtccagcc cgcgctgttc gcgatgatgg 72660 tcggcctcgc cgcggtctgg cgcgcccacg gcgtcgagcc ggctgcggtc gtcggccact 72720 cgcagggcga gatcgccgcc gcccacgtgg cgggtgcgct cgacctcgac gacgcggcgc 72780 gggtggtggc gctgcgcagc cgcgcgctgc cccggctgtc cgggcacggc gggatggtct 72840 cggtcgcggc gcccgtcggc cgggtcaccg agctcatcgt gccctggggc ggcgcgctgt 72900 cggtcgccgc ggtcaacggg ccgtcgtcgg tcgtcgtctc cggcgacgcg gacgcgctcg 72960 acgcgctgct gcccgcctgc gagtccgccg gggtgcgggc ccggcgggtc tcggtggact 73020 acgcctcgca cggcccgcac gtcgaggccg tgcgcgacga gctcgccgag gtcctcgccg 73080 gcatcactcc gcgcaccccg acggtgccgt tctactccac cgtcaccggc gggcgcctcg 73140 acaccgccga ggacggtggc ctcgacggca cctactggta caccaacctc cgcaccaccg 73200 tccggatgca ggacgccacc gaggcgctcc tcgcggccgg gcaccggatc ttcgtggagg 73260 tcagcccgca cccggtgctc gccggaccgg tccaggagac ccaggaggcg gccgaccccg 73320 acggcaccgc cgccgcggtc gtgctgggca cgctgcgccg cgacgagggc ggccccgccc 73380 gggtgctgac ctcgctggcc gaggcctatg tgcacggcgc caccgtcgac tggaccacca 73440 ccctgcccga caccggcggc acagacgtcg aactgccgac ctacgcgttc cggcgccgca 73500 gctactggcc cgagccgaag gcggacccgt cgggcgccgc cgacgacgcc gcgttctggg 73560 cactggtcga cgggcaggac ccggcggcgt tcgccgacgc gctcggcgtg cccggcggcg 73620 cactcgacac cgtgctgccc gcgctgtccg catggcgcgc cgggtcccgc gcccgcaccc 73680 gggccaacga cctgcgctac cgggtcgact gggcaccggt ccccgagccc gccgcgggcc 73740 cgccggccgg gcgggtactg gtcatcggcc acgacgcggg gaccggcacc gacgacgacg 73800 ggctgctcgc ggcgttcggc cccggcgccg tcccggtcac cgaccccggg accggccgcg 73860 ccgcgtgggc cgccgagctg gcccggcacg ccgccgacgg cccggtcacc gcggtcgtgg 73920 ccctcccgga cccgacggga cggccgcatc cggggcaccc gggcgtcccc ggtgcgctgg 73980 cccggaccct cacgctggtc caggcactcg gcgacgccga cgtcacggcg ccgctgtggt 74040 gcctgacccg cggtgccgtc gggacggcgc ccggtgacgc ggtcaccgat cccgagcagg 74100 gcaccctgtg gggcctcggc cgggtcgtcg cgctcgagca ccccgaccgg tggggcgggt 74160 tgatcgacct gccggggacc ccggaccccc ggaccgcggc gcgggtcgcc gggctggtca 74220 ccggggccgg gaccgaggac cagctggcgg tccggccgca cggggtcctc gcccgacggc 74280 tcgttcacgc ggccccggcc gcgccgcgcc ccggacacgg cggctgcgac cgcggcaccg 74340 tgctggtgac cggcgggacc ggcggcatcg gcggacggac ggcggtgtgg gccgccggcc 74400 gcggcgccga gcacctgctg ctgaccagcc gccgcggcga ggacgccccc ggcgccgccg 74460 cactgcgcac cgagctggag tcgctcggcg cccgggtcac gatcgccgcc tgcgacgccg 74520 ccgaccggga cgcactcgcc accctgctcg acgagctgcc cgcggacctg ccgctgaccg 74580 ccgtcgtcca ctcggcgggc gtcgccgacg gggacgcccc cgtcgcggac ctgaccgtgg 74640 accggctcga cgcgctgctg cgggccaagc tgaccgcggc ccggaacctg cacgagctca 74700 cccgcgggac ggagctcgac gcgttcgtgc tgtacagctc cggggcggcg gtctggggca 74760 gcggcggcca gcccggctac gccgcggcca acgcctacct cgacgccctc gccgcgcacc 74820 gacgcgggct cgggctcccg gcgacgtcgg tcgcctgggg gacgttcggc gaggtcggca 74880 tggccaccga tccgcaggtg cacgagcggc tgcaccgcca gggcgtcccg gcgatggacc 74940 cggccgacgc actggccgcg ctggagctgg ccctcggcga gggcgacacc ggcgtggcgg 75000 tgacccgcat ggactgggag gtcttcgcgc cgagcttcac cgcgctgcgc cccagcccgc 75060 tgctgggcac ggtgcccgag gcggtcgccg cgctcgccga cgggccggcc ccggtccccg 75120 gcgaccccgg cgcggacgcg gccgtcccgc cgctgcgcgg gcgcctggag gcgttgccga 75180 ccgcggaacg ggcccgggcg ctcgtcgagg cggtccgcgg cgaggcggcg gccaccctcg 75240 gccacgacgg cgccgacgcg atccccgccg ggcgcgcgtt ccgcgacgtc gggttcgact 75300 cggtgaccgc ggtggagctg cgcaaccggc tgcgtggcgg gctcgggctg ccgctgcccg 75360 cggcgctcgt cttcgaccac ccgacaccca ccgacctggc ccgccacctg gggacgctgc 75420 tgttcggtga cacccccggc gagcagggca ccacccgcac cgacgacccc gacgcccaca 75480 tccgtgaggt cctcgcctcc gtccccatcg gacggctgcg gcgggcgggc ctgctggaca 75540 tggtgctggg cctcgccgac gccgaacccg gtgccgccga cgaccccgac cccgacgcgg 75600 gccggaccga cgacggcggc gcggagtccc tcgacgacat ggatgccgaa gcgctgctgc 75660 ggctcgtcac cgagaactcg gcgaactgac ctcggcgaac tgaacgacaa gcaggagatt 75720 ctgatgagca cgtcggacca gaagtacgtc gaggcactcc ggtcgtccct caaggaggtc 75780 gagcggctcc gcaggcagaa cgagcagctg gtcgccgccg cgtccgagcc ggtcgcggtc 75840 gtcggcatcg gctgccgctt ccccggtggc gtcgcctcgc cggaggacct gtgggacgtc 75900 gtcgcgcacg gccgggacgt cctcgggccg ttcccgaccg accgcggctg ggacctcgac 75960 gcgctcgccg gtgacggcga gggcggcagc ctggcccagg tcggcggctt cgtcgacgac 76020 gtcgccggct tcgaccccgg cttcttcggg atctccccgc gcgaggccgt cgcgatggac 76080 ccgcagcagc ggatcctgct ggagatcacc tgggaggcgc tggagcgggc cggcatcgac 76140 ccgacgtcgc tgcgcggcac cgacaccggg gtcttcgtcg gcaccaccgg ccaggactac 76200 ggcgaggtga tccgcgcctc cgacgaggac gtggcggtct actcgaccac cgggcacgcc 76260 gcgagcgtca tctccgggcg actgtcctac accctgggcg ccgagggccc ggcggtcacc 76320 gtcgacaccg gctgctcgtc gtcgctggtc gccatgcacc aggcggtgca ggcgctgcgg 76380 gccggggagt gctcgacggc gctggccggt ggcgcgtcgg tgatggccac ccccggcccg 76440 ttcgtcgcct tcaccgccca gagcgggctg gccgccgacg gccgctgcaa gccgttcgcc 76500 gacggcgcgg acggcaccgg ctgggccgag ggcgccggga tgctcgtgct gatgcggctc 76560 tccgacgccc gccggcaggg ccgcgaggtc ctcgcggtcc tgcgcgggtc cgcgatcaac 76620 caggacggcg cctccaacgg cctgaccgcc cccaacggcc cgtcccagca gcgggtgatc 76680 cgggccgcgc tggagagcgc gcggctgggc tccggtgacg tcgacgccgt cgaggcgcac 76740 ggcaccggca ccaccctggg cgacccgatc gaggcgcagg ccctgctcgc gacctacggc 76800 gcggaccgcg cgaccccgct gctgctgggc tcggtgaagt ccaacatggg ccacacccag 76860 gccgcgtcgg gcgtcgccgg cgtcatcaag atgatcatgg cgctgcggca cggggtgctg 76920 ccccgcagcc tgcacgccga gcgcccctcg gccgacgtcg actggaccgc gggcgccgtg 76980 gcactgctcg acgctgccgt cgactggccg gagaccggcc gcccgcgccg ggcaggggtc 77040 tcctcgttcg ggatcagcgg cacgaacgcc cacgtcatcc tggagcaggc cccgcacacc 77100 gacgcgcagg cacctgccgc cgaggtgtcc gccccggcgg tggtgccgtg gccgctgtcc 77160 gcacgcaccg ccaccgcact ggacaccctg cgggcccggc tcacgggatc ggtcaccgga 77220 ctgagcccgc tcgacgtcgg tgcctcgctg gccaccggcc gtgcgacctt cgagcaccgc 77280 gccgtgctgc tcggctccgg ggacgaggtc accgagatcg cccgcggtgt cgcgggggag 77340 ggcctgaccg cgctgctgtt ctccgggcag ggctcccagc gcctgggcgc cggccgggag 77400 ctgcacgccc gcttcccggt gttcgccgag gcgttcgacg agaccgccgc gctgctcgac 77460 gcggcgctgc ccgacaacga cgccaccctg cgtgaggtcc tgtggggcac cgacgccgag 77520 gcgctcgacg acaccggccg ggcgcagccc gcgctgttcg cgatcgaggt cgccctctac 77580 cgcctggtca cctcgctggg cgtggtcccg gacctcgtcg gcgggcactc gatcggcgag 77640 atcgccgccg cgcacgtcgc gggcgtgctg tccctcgacg acgccgccac gctcgtcgcc 77700 gcccgcgccc ggctgatggc cgcgctgccg cgcggcggcg cgatgctggc cgtgggcgcg 77760 accgaggacg aggtcgcacc cctgctcacc gccggtgtct cgctcgccgc ggtcaacggg 77820 ccgtcgtcgg tcgtggtggc cggggacacc gacgggatcg ccgccgtcga ggagcacgcc 77880 cgcgcccggg ggtggcgcag cacccggctg cgggtcagcc acgcgttcca ctcgccgctg 77940 atggagccga tgctcgccga gttccgggcc gtcgccgccg gactcaccta ccacgagcca 78000 cggatcccgg tcgtctccaa cctgaccggc tcggtcgccg aggtcgccga catctgctcc 78060 gccgactact gggtgcgcca cgtccgcggc accgtccgct tcgccgacgg cgtcaccgcc 78120 ctggccgcgc gcggcgtcac caccctggtc gagctcggcc cggacggcgt gctctgcggc 78180 atggcgcagg agtccctgcc cgagggcgcc gtcgccgtac cgctgctgcg ccgcgaccgc 78240 cccgaggagc tgtcgctggt caccggactc gccacggccc acgtccgcgg gacgaccgtg 78300 gactgggccc ggctcttcga cggcaccggt gcgtcccggg tcgacctgcc cacctacccc 78360 ttcgagcaca cccgctactg gcccgcgccc gtccggggcg ccgccgacgt caccgccgcc 78420 gggctgacca ccgccgacca cccgctgctc ggtgccgccg tcgagctcgc cggtgacgac 78480 ggcgtgctgt tcaccagcag gctctcggtc cgcacccacc cgtggctcgc cgaccacggc 78540 gtgcagggac gtgcgctgct gccgggtacc gcgttcgtcg agctggcggt gcgcgccggt 78600 gacgaggtcg gctgcacccg ggtggaggag ctgaccctgg ccgcgcccct cgtgctcccc 78660 gagcgcggtg gcgtgcgggt gcaggtccgc gtcggtccgg cggacgcccg tggccgccgc 78720 accctcggcg tgttctcccg gccggaggac gccgacggcc tgccctggtc gcagcacgcc 78780 accggtgtgc tcggctcggg aacgacggcg cccgacgggc tcgacacgac cgcctggccg 78840 cccgccggcg ccgagccggt cgacctcgag ggctgctacg agcggctcgc cgggatcggc 78900 ttcgactacg ggccctcctt ccgggggctg cacgccgcgt ggcgccgcga cggcgaggtg 78960 ttcgccgagg tcacgctgcc cgacggcgcc gggaccgaca cgaccggttt cggcctgcac 79020 cccgccctgc tcgacgccgc gcagcacgcc gccgcctacg gcgacctggg tgcgatcagc 79080 cgtggcggcc tgcccttcac ctgggagggc gtccagctgt tcgccgcggg cgccggcacc 79140 gtccgcgccc ggatcgcggc caccggcgag gacaccgtgt cgatcacggt gtacgacgcc 79200 gcgggcgggc cggtgctgac ggcggactcc ctggtctccc gcgaggtccc ggccgacacc 79260 ggcgccgacc ggtacgacga ctccctgttc cgccaggact gggccccgct gggcggcccc 79320 gccggccgga ccccggcggc ggtcgccgtc gtcggcgccg agaccggcgg ccccggcccg 79380 gtcggcacgg ccgcactgcg ggccgcgggc gtccccgtgc gcacctaccc ggatctcacc 79440 gcgctggccg cctccggcga ccccgtcccc gagctcgtgc tggccggggc cgcgtcctgc 79500 ggcggcaccg tcgccgacgc cgcgcacacc gtcgccaccg cggccctgga gctggtgcag 79560 cagtggctgt ccggcgagga gttcgccgac gcccggctcg tgctgctcac ccgcggcgcc 79620 accgacggcg ccgacccggc cgccgccgcg gtgcacggcc tcgtccgcac cgcccgcacc 79680 gagaacccgg gccggctggc ggtcctcgac ctgcccgacg acgccaccgg cgccgatccg 79740 gtcgtggccc ccgccgcact ggtcgccgcg ctcgccgcca ccgaggacga gcccgacctc 79800 gccgtccgcg ccgacacggt gctcgtgccg cggctggtcc gggtccgcac cgacgccgag 79860 ccgcaccggt ggaaccccga cggcaccgtc ctgatcaccg gcgggaccgg cggcctcggc 79920 ggtgtcctgg cccggcacct cgtcgccgag cacggcgtac ggcagctgct gctggccggc 79980 cgtcgcggtc cggacgcccc cggcgccgcc gagctggtcg acgagctcac cgcgctgggc 80040 gcgaccgcgc acgccgtggc ctgcgacgtc accgaccggg ccgcggtcgc cgcgctgctc 80 100 gccggcatcc ccgacacgca cccgctgacc gccgtcgtgc acaccgcggg cgtcgtcgac 80160 gacggcgtga tcggctcgct gaccccggag cgcctcgaca ccgtgctgcg ccccaaggcc 80220 gacgcggcct ggcacctgca cgagctcacc cgcgacctgg acctggacgc cttcgtcctg 80 280 ttctcctcgg tcgccgccac cttcggcagc cccgggcagg ccaactacgc cgcggggaac 80340 gccttcctcg acgcgctggc cgtgcaccga cggtcggccg ggctgcccgc cgtcgcgctg 80 400 gcctgggggc cgtggagccg cgtcgtcggc atgacgggct cgctcagcga cgtcgacgtg 80460 gagcggatcg cccgctccgg gatgccaccg ctgaccccgg agcaggggac ggccctgttc 80520 gacgccgccc tcgcggcgac cgccgacgga accgccgcgc tcgccccggt ccggctcgac 80580 ctgcccgccc tgcgcgccca gggcgagccc gcgccgctgc tgcgcggcct gatccggcgc 80640 cccgcgcggc gcgccgccgc ccaggcgtcg ccgtccaccg gtgacctcgc cgagcggctc 80700 cgcgcgctgg acgggtccac ccgtgacgag gcgctgctcg acctcgtccg cgagcggatc 80760 gcccacgtcc tcggccacgc cgaccccggc caggtcgaga ccggccgtca gttccaggac 80820 ctcggcttcg actcgctcac cgcggtcgag ctgcgcaacg gactcaccgc cgccaccggg 80880 ctgcgcctgc ccgcgaccat ggtcttcgac tacccgacgc cgggcgtgct ggcccgccac 80940 ctgcgcgacg agctgctcgg tgccgacgac gcccccgacg acaccgccga ccgcaccccc 81000 gacaggaccg ccgcttcctc ggccgcgacc ggcgacgatc ccgtcgtgat cgtcgggatg 81060 gcgtgccgct accccggcgg tgtcggctcc ccggaggacc tgtggcggct cgtcggcgac 81120 ggtgccgacg cgaccggccc gttcccgacc gaccgcggct gggacctggc caacctgttc 81180 gacgcggacc cggaccgtcc cgggcacacc cacgtccgcg ccggcgggtt cctgcacacc 81240 gcccccgagt tcgacgccgg gttcttcggg atgagcccgc gcgaggcgct gtccaccgac 81300 tcgcagcagc ggctgctgct ggagacgagc tgggaggcga tcgagcgggc cgggatcgac 81360 ccgaccgggc tgcgcggcag cgccaccggt gtgttcgccg gtgtcatgta caacgactac 81420 ggcaccacgc tgaccggcga cgagcacgag gccttccgcg gcaacggcag cgcccccagc 81480 gtcgcgtccg gccgcgtgtc ctacaccctg ggcctggagg gccctgcggt caccgtcgac 81540 accgcgtgct cgtcgtcgct ggtcgggatg cacctggccg cgcaggcgct gcgggcgggg 81600 gagtgcaccc tcgccctcgc cgggggcgtg acggtcatgt cgacacccag cacgttcgtc 81660 gacttctccc gccagcgcgg actcgcgccc gacggccgct ccaaggcctt cgccgacgcc 81720 gccgacggcg tcgcctggtc cgagggcgtc ggcgtgctcg tcctggagcg gcggtccgac 81780 gcactccgca acggtcacga gatcctcgcg gtgctgcgcg ggtcggcggt caaccaggac 81840 ggcgcctcga acgggctcac ggcgccgaac ggcccgtccc agcagcgggt catccgccgc 81900 gcgctggcga acgccggtct gtccaccggc gacgtcgacg tcgtcgaggc acacggcacc 81960 ggcaccaccc tcggcgaccc gatcgaggcc caggccctga tcgcgaccta cgggcgggac 82020 cgggacccgc agcggccgct gctgctcggg tcggtgaagt ccaacatcgg ccacacccag 82080 gccgccgccg gtgtggcggg tgtgatcaag atggtgctgg cgatgcggca cgggacggtg 82140 ccgcgcacgt tgcacgtgga cgcgccgtcc tcgcacgtgg actggtccga cggcacggtc 82200 gcgctgctca ccgagccgac gccgtggccc gagaccgggc gcccccgccg ggcgggcgtg 82260 tcgtcgttcg gcatcagcgg caccaacgcc cacgtcatcg tcgagcagcc ggagccgacg 82320 ccgaccaccg ccaccgtcgg tggccgggag ctgcccgccg tgccgtgggc gctgtcgggc 82380 gcctccgccg acgcgctgcg cgaccaggcc gcccgcctgc tcacccacgt ccgcgacggc 82440 cacgccgtcg accccgcgat cgatcccgcg atcgaccccg ccgacgtcgg ctggtccctg 82500 ctgcgcaccc gcgccgccct cgatcagcgc gcggtcgtcg tcggcaccgg ggcggagcag 82560 accctgcgcg gcctggcggc gctcgccgcg ggcgaggccg acccggccgt cgtcaccggc 82620 accaccgcga ccggccgtac cgcgttcctg ttctccgggc agggctcgca gcgcctcggc 82680 atgggccgcg agctgcacgc ccggtacccg gccttcgccg acgccttcga cgccgcactg 82740 tccgcgctgg acgccgagct gggctccgac ctgcgtgcgg tcgtctgggg ccacggtgac 82800 agcgccgggg ccgcactgga cgcgaccggc gccacccaac cggcgctgtt cgcgctggag 82860 gtcgcgctgt accggctgct ggagtcctgg ggcgtcgccc ccgacctcgt cgccggccac 82920 tccgtcggcg agatcgccgc cgcccacgtg gcgggggtgt tcaccctcgc cgacgccgcg 82980 cggctggtcg ccgcccgcgg caccctgatg caggcgctgc ccgccggcgg cgcgatggtc 83040 gccgtcgagg cgaccgagga cgaggtcgcc gctctgctca cccgcgacga cgtcgcgatc 83100 gccgcggtca acggcccgtc ggccgtcgtc gtgtccggct cgcaggacgg cgtcgacgcc 83160 gtcgcggcgg cgctcgccga gggcgggcga cggaccagca ggctgagggt cagccacgcg 83220 ttccactcgc cgctgatgga gccgatgctc gccgagttcc gctccgtggt cgccggcctg 83280 tccccggagg ccccggcggt gcccgtggtc tcctccctga ccggtgacct cgccggtgcc 83340 gacgagctgt gcgaccccgg gtactgggtg cgccacgtcc gcgaacccgt ccggttcgcc 83400 gacgccgtca ccaccctcgc cggccgcggc gccgtcacct tcgtcgagat cggccccggc 83460 ggcgtgctgt cggccatggc ccaggactcg ctgcccgccg acgggaccgt caccgtgccc 83520 gtgctgcacg gcgagggctc cgaggacgtc gccgtcgtcg ccgcgctcgc cgcgctgcac 83580 gtccgcggcg tacggatcga ctgggacgcc gtgttcgacg gcaccggcgc cgcccgcgtc 83640 gacctgccga cctacgcctt ccagcaccgc cgctactggc cgggtgccac cgcggccccc 83700 ggcgacgtcc gctccgccgg gctcggcgcc gccgggcacc cgctgctcgg cgccgccgtc 83760 gcgttccccg acggcgcggg cgcgctgctg accggccgtc tctcggcgtc cgcgcagccg 83820 tggctcgccg accacacggt cgccgggacc gtggtgctgc ccgggaccgc gctgctcgag 83880 ctcgccgtcc gcgcgggcga cgaggtcggc tgcaccggcg tcgaggagct caccctcgcc 83940 acgccgctga ccctgcccac cgcgggtggc gccgtcaccg tgcaggtccg cgccggtgcc 84000 gacgacggtt ccggccgacg cccggtcacc gtgcacgccc gccccgaggg ctccgacgag 84060 tggaccgagc acgccaccgg caccctcacc accctcgcgc cgggcccagt gcggttcgac 84120 gccacgacct ggccgcccac cggcgcggcc gagctcgacg tcgagggctg ctacgagcgg 84180 ttcgccgagg ccgggttcgg ctacggtccg gtgttccggg ggctgaccgg cgcctggcgg 84240 gacggcgaca ccgtctacgc cgaggtgtcg ctgcccgacc ccgacaccac cgccgaggac 84300 gcggcccgct tcgggctgca ccccgccctg ctcgacgccg ccctgcacgc cgccctgctc 84360 accggtgacg gcgccgcggg ccttccgtgg gcctgggagg acgtcaccct gcacgccgcc 84420 ggggccaccg cgctgcgggt gcgcctcgca ccggccaccg acggcggcgg cctggccgtc 84 480 gccgtcgccg accccgaggg tcgtccggtc gccaccgccg gccgtctgcg cgcgcgcccc 84540 gtcgaccctg ccgccctcgg caccgggacg gccgtgcgcg acggcctgtt ccggctcgac 84600 tggacggccg tcacggcgcc gtcggaccag tccgtgccgc cggcgccggt cgcggtgctc 84660 ggcgcgcccg gcgacccggt caccgacgtc ctcgccgccg ggcacacccg gtacgacacc 84720 gtcgacgacc tgctcgccga ccccggcagc accgtcccgg cgaccgtgct cgccccgctc 84780 ccggccggcc ccggcgacga cacgccgcgg gacgtgcgcg accgcaccgg cgcgaccctg 84840 gacctgctcc ggcgctggtc gaccgaggac cggctcgccg gctcccggct ggtactcgtc 84900 acccgcggcg ccgtcacgga cgccggtgag cccgtcgccg acctcgccgc cgccgcggtg 84960 tgggggctgg tccgctccgc gcagaccgag aaccccggcg ccttcggcct gctcgacctc 85020 gacccggccg ccgccgtgcc cgcgaccggt gccctgcccg tcgcgctgtc cccggacgag 85080 ccgcagctcg ccgtccgcgg ggacgacgtc ctcgccgccc gtctgacccg cgccggggcc 85140 cccaccggcg ccacgacgtg gtcgaccgag ggcaccgtcc tggtcaccgg cggcaccggt 85200 ggcctcggcg gtctgctcgc ccgtcacctc gtcgccaccc acggggtgcg ccacctgctg 85260 ctgaccagcc ggtccggtgc ggacgcaccg ggggccgcgg agctggtcgc cgagctggag 85320 ggccatggcg cccgggtgtc ggtcgccgcc tgcgacgtca ccgacgccga cgccgtcacc 85380 gcgctggtgg ccggtgtgcc cggtgcgcac ccgctgcgtg ccgtcgtgca caccgccggg 85440 atcctcgacg acggggtgct gagctcgctc acccccgggc gtctggcccg ggtgctggcg 85500 ccgaaggtgg acggtgcgtg gaacctgcac cgcgcgaccg cgggtctgga cctggacgcg 85560 ttcgtgctgt tctcctcggt cgccggggtg ttcggcggtg ccggccaggc gaactatgcc 85620 gccggcaacg cgttcctcga cgccctggcc gcgcaccgcg ccgccgccgg cctgcccgcc 85680 accgcgctgg cctggggccc ctggcagcag ggcctcggca tgaccgccga cctcgaccag 85740 cgcgacgtcg cccgggccgc cgccgccggg atgccgctgc tcaccgccga cgagggcctc 85800 gccctcttcg acgccgcacc ggccaccggc gaccctgcgc tggtcaccgc ccgcctcgac 85860 ctcgccgcgt tccgcgcccg gaccccggtc cccgcgctgc tgcgcggact ggtcaccgcc 85920 ccccgccgca ccgccgccgg cgccgcgcag gccaccgacg ccgggctcgt cgcccggctc 85980 gcccggctcg acgacgaccg gcgccacgag gtcctcctcg acgtcgtccg cgacgccgcc 86040 gccctcgtgc tcgggcacac ctccggcgcc gacatcgacg ccgaccgcgc cttccgcgat 86 100 ctcgggttcg actccctgac cgccgtcgag ctgcgcaaca ggctcgcgac ggcgaccggg 86160 ctgcggttgc ccgcgacgac ggtcttcgac cacccgaccc tctccgcgct cgccacccac 86220 ctgcgctccg agctgctcgg ctccgcggcc ccgcccgcac cggagcgccc ggtcgtgacg 86280 ccgctcgacg acgacccggt cgtcatcgtg ggaatggcgt gccgcttccc cggcggggtc 86340 acgtcccccg aggacctctg gcagctcgtc ggcgacggcg tcgacgccat caccgggttc 86400 cccaccggcc gcggctggga cctcgacggc ctctacgacc cggaccccga ccacgccggc 86460 acctcctaca cccgcgaggg tggcttcctg cacgacgccg ccgagttcga tgccgggttc 86520 ttcgggatga gcccgcggga ggccaccgcg accgacgcgc agcagcggct gctgctggag 86580 acgagctggg aggcggtcga gagggccggg atcgacccgg tctcgctgcg cggcagcgcc 86640 accggcgtct tcgccggcgt catgtaccac gactacgccg acaacctcgg cggaccggag 86700 cacgagggga tccagggcca gggcagcgcg ggcagcgtcg cctcgggccg ggtgtcctac 86760 accctggggc tggagggccc ggcggtcacc gtcgacaccg cgtgctcgtc gtcgctggtc 86820 gcgatgcact gggcgatgca ggccctgcgg accggcgagt gcacgctcgc cctcgccggc 86880 ggcgtaaccg tcatgtccac cccggccacg ttcgtcgagt tctcccggca gggcggcctc 86940 gccgccgacg gccggtccaa gcccttcgcc gacgccgccg acggcgtcgg ctgggccgag 87000 ggcgccggca tgctggtgct ggagcgccgg tcggacgcgc tgcggaacgg tcacgagatc 87060 ctcgccgtgg tgcgcgggtc ggcggtgaac caggacggtg cgtccaacgg gctcacggca 87120 ccgaacgggc cgtcccagca gcgggtcatc cgccaggcac tggccagcgc cgggctgcgg 87180 gcatcggacg tcgacgcggt cgaggcccac ggcaccggca ccaccctcgg cgaccccatc 87240 gaggcgcagg cgctcatcgc gacctacggc gccgaccgcg accccgcgca gccgctgcac 87300 ctgggttcgc tgaagtccaa catcgggcac acccaggccg ccgccggcgt cgccggtgtg 87360 atcaagatgg tgcaggcgct gcggcacggg gtgctgccgc ggacgctgca cgtggacgcg 87420 ccgtcctcgc acgtggactg gtccgacggc accgtcgcgt tgctcaccga gccgaccgtg 87 480 tggccggaga ccggccgtgt ccgccgggcg ggtgtgtcgt cgttcgggat cagcggcacc 87540 aacgcccacg tcatcgtcga gcagcccgcc gacgccccgg ccccctcccc ggcagagccc 87600 ggacccgacg gcccgctgcc gtggctgctg tccgcgaggt cccccgaggc gctgcgcgac 87660 caggcggccc ggctccgcga cgccgtcacc gggcggccgg acctgcgccc gatcgacgtc 87720 gcccactccc tggcgaccgg ccggtccgcg ttcgaccacc gcgccgtcgt cctcgcggcc 87780 gacgccgacg acgccgtgcg tgctctcacc gcgctcgccg acggcgacag cgacccggcg 87840 gtcgtcaccg gccgtgcccg cggcggccgg accgccatgc tgttctccgg gcagggttcg 87900 cagcggctcg gcatgggccg ggagctgcac gcccggttcc cggtgttcgc cgacgcgttc 87960 gacgccgtcg tcgccgcgct ggacgccgag ctcggcggtg acctgcgggc ggtcgtgtgg 88020 ggcaccgacg ccgccgcgct ggacgagacc ggcgcgaccc agcccgcgct gttcgcggtc 88080 gaggtcgcgc tgcaccggct cgtcgagtcc tggggggtcc gtgccgacct ggtcgccggg 88 140 cactcgatcg gcgagatcgc cgcggcccac gtggccgggg tgttctcgct ggccgacgcg 88200 gcgcgcctgg tcgcggcgcg ggcgtcgctg atgcaggcgc tgccgaccgg gggcgccatg 88260 ctcgccgtgc aggcgagcga ggacgaggtg cgcccgcacc tcaccgacgg cgtcgcgatc 88320 gcggcggtca acggcccgtc cgctgtcgtc gtctccggtg acgaggatgc cgtgacggcg 88380 gtgggcgagc agctggccgg ccgcaggaca cggcggctcg cggtgtccca cgcgttccac 88440 tcgccgctga tggacccgat gctggcggag ttccgggccg tcgccgagca gctgagctac 88500 gccgagccgg tggtgccggt ggtgtcgaac ctgaccggtg cgctcgccga gccccggcag 88560 ctgtgcgacc cggagtactg ggtgcgccac gtccgcgagg ccgtccgctt cggcgacggc 88620 gtgcgggcgc tggccggggc cggtgcgacc acgttcctgg agctcggccc ggacggggtg 88680 ctctcggcga tggcccgcga gtccctgccc gacgacacga ccgcgacggt gcccgtcctg 88740 cgccgcgacc gcggcgaggt cgacgccgca ctgaccgcgc tggcccggct gcacgtcggc 88800 ggcacccgcg tcggttggac ggagctgctc ccgggcggcc gccgggtcga cctcccgacc 88860 tacgccttcc agcacgccac ctactggccc accgcgaccc gcccggcggc cgacgccggc 88920 gcgctcggac tcaccgccac cgggcacccc gtcctgcacg gcgtggtcga gctcgccgag 88980 ggcgagggcg tgctctgcac cggtcggctg tcgctcgcga cccacccgtg gctgaccgac 89040 cacgccgtcc ggggcaccgt cctcgtgccc ggcacggcgc tgctcgaact ggccctgcgc 89100 gccggcgacg aggtcggctg cgaccgcgtc gaggagctca ccctcgccgc cccgctggtg 89160 gtgcccaccc gtggtgccgt gcggacccag gtccgggtcg gcgtcgccga cgacgacggc 89220 cgccgcaccg tcaccgtgca cgcccggccc gacgacgccg gcgacgcacc ctggacccag 89280 cacgccgccg gcaccctgac cacggccgca ccggagccga ccggcttcga cgccacgacc 89340 tggccgccca ccggtgcgcg cgagctgccg ctccggggtt gctacgagcg gttcgccgag 89400 gccgggttcg gttacggccc ggtgttccag ggactgaccg gcgcctggca ggacggcgac 89460 accgtctacg ccgaggtcgc actgcccggg caggccaccg acgacgcggc ccgcttcggg 89520 ctgcaccccg ccctgctcga cgccgccctg cacgccggga tgctcgacga cgacggcacc 89580 gcaggcctcc cgttctcctg ggacggggtc actctgcacg ccaccggcgc cgtcgcgctg 89640 cgcgtgcggc tgacccgcac cggcggcggc atcgcgatcg ccgccgccga cccggcgggc 89700 cacccggtcg cgaccgtcga cacgctcgcc gtccgcccgg tcgccgaggc acagctcgca 89760 cccaccggca ccggcgacgc actgttcgcg ctcgactgga ccccggtcga cgacgccccg 89820 gccggcatcc cggcgcccgc gacggtcgcc gtcgtcggca tcggcgtcgg ggacgaccac 89880 ggggacagcg cagccgccga ggtcgccgcg ggcctgtccg ccgcgggcac cgacgcgacc 89940 gtccacaccg gccccgccac ggcgatcgag gagctggggg acacggtggt cgtcaccgtg 90000 gacggtgaag gtgccgacac ggcgaccgcc gcccacaccc tgaccgccgc cgtcctcgac 90060 ctgctgcagc agtggaccgc cgggaccggt tccgggcggc tcgccgtcgt cacccggggc 90120 gccgtcgccg ccggggggac cgcacccacc gacgtcgccg ccgccgcggt gcacggcctc 90180 gtccgctccg cccggtccga gttccccgac ggcatcgtgc tcgtcgacct cgatccggcg 90240 accgccggcg ccgcggacga cggtccgctg ctgctcgccg cgctgcacac cggtgagccg 90 300 cagatcgcgg tgcgcgacgg tgccctgctc gccgggcgcc tgacccgggc gcagaccggc 90360 tccggtctcg tcgtgccggc ggtggacgcc tggtgcctcg acagcaccac cccgggcagc 90420 atcgacggcc tcgccctcgt gccccacccg gaggcgggcg ccccgctcac cggtcaccag 90 480 gtgcgggtcg cgatccgcgc cgcgggcctg aacttccgcg acgtgctcaa gtccctcgac 90540 atgtaccccg gcgacgccgg ccgctacggc cacgaggcgg cgggggtggt cctcgcgacc 90600 ggcccggacg tcaccgggct cgccccgggc gaccgcgtcc tgggcatgat ctcgggcagc 90660 ttctcctcgg tggccgtcga cgacgcccgc cgcctcaccc ggatcccgga cggctgggac 90720 tgggagaccg ccgcgtcggt cccgctggtc ttcctcaccg cctggcacgc cctgcgccag 90780 ctcgggaacc tgacggcggg ggagaaggtg ctcgtccacg ccggtgccgg tggcgtcggc 90840 atggccgcgg tccagatcgc ccggcacctc ggtgccgagg tgtacgcgac ggcgtcggag 90900 cccaagcagc acgtgctgcg cagcctgggc gtcgccgagg accacatcgc ctcctcgcgg 90960 accctggagt tcgccgagac cttcgccggg acggacctcg acgtcgtcct caactcgctg 91020 gccggggagt tcgtcgacgc ctcgatgggg ctgctcggcg acggcggccg gttcctggag 91080 atgggcaaga ccgacatccg cgacgcggac tccgcgccgg ccggcgtctc ctaccaggcc 91140 ttcgacctcg cctgggtcga gcccgaggcc atcggcgcca tgttcgccga gctgatggac 91200 ctcttcgcgg ccggcgtgct ggacccgctg ccggtccgca cctgggacgt ccgcgacgcc 91260 cccgccgcgt tccgcttcat gagcgccgcc cagcacatcg gcaagatcgt cctgaccctc 91320 ccgcggccgt ggaccaccga gggcaccgtc ctggtcaccg gcggcaccgg tggcctgggc 91380 gggctgctcg cccgtcacct ggtcgcgacc cacggggtgc ggcatctgct gctgaccagc 91440 cggtccggtg cggacgcgcc gggtgctgcg gagctggtgt ccgagctcgg tgagctgggt 91500 gcgcaggtgt cggtggcggc gtgtgacgtc accgacgccg atgcggtcgc cgcgttggtg 91560 gccggtgtgc ccggtggcca cccgctgcgt gccgtcgtgc acaccgccgg tgtgctggac 91620 gacggggtgc tggcctcgct cacgcccggg cgtctggcgc gggtgctggc gccgaaggtg 91680 gacggtgcgt ggaacctgca ccgcgcgacc gagcacctgg atctggacgc gttcgtgctg 91740 ttctcctcgg tggccggggt gttcggcggg gccgggcagg cgaactatgc cgccggcaac 91800 gcgttcctcg acgccctggc cgcgcaccgc gccgccgccg gcctgcccgg cgtgtccctg 91860 gcctggggcg cgtggggcca ggaggccggc atgaccgccg gtctcgacga gcgcgacgtc 91920 cgccgggccg ccgagtccgg gatgccgctg ctcgccgcag ggcaggccct cgccctgttc 91980 gacgccgccc tcgccacggg gcgtcccgcg ctcgtcccgg tgcggctcga cctggccacg 92040 ctgcaccgtc gcgggaccgt cccgccgctg ctgcgcgggc tcgtccgcgc ccccgcccgc 92100 cgcgccgcga cgaccacggc ggccgacgcc ggcggcctgg ccgggcggct cggtgccctc 92160 ggccgcgccg agcggcgcgc cgccctgctc gacctggtcc gcggtgaggc cgcgaccgtg 92220 ctcgggcacg cgggcggtga ccgcatcgac cccgagctgg ccttccgcga cctcggcttc 92280 gactcgctga ccgccgtcga gctgcgcaac aagctcggcg ccgccaccgg tctgcggctg 92340 cccgccaccg cgatcttcga ctacccgacg gtcgtcgcgc tcgccgagca cctgctcgtc 92400 gggctcctcg gcccggacgc cgacggcgac tccgggaccg gcgccgacat cgccgggatc 92460 accacggccg acgaccccgt cgtcgtcgtg gggatgagct gccgcttccc cggcgggatc 92520 ggctcgcccg aggacctgtg gcgggtcctc gacgagggca ccgacgtgat cgccgggttc 92580 ccgaccgacc gcggctggga cctcgacgac ctgttcgacg acgatcccgc gcaccgcggc 92640 acctcctacg cccgctccgg cgggttcctc gacgacgccg ccggcttcga cgcggacttc 92700 ttcgggatga gcccgcgcga ggcgatggcg accgacgccc agcagcggct gctgctggag 92760 tcgtcgtggg aggcgatcga gcgcgccggg ctggacccgc acagcctgcg ggacagccgg 92820 accggtgtgt tcgccggcgt catgtactcg ggctacggca cccgtctgga cggcgacgag 92880 ttcgagggct tccagggcca gggcagcgcg ctgtcggtgg cctcgggccg catctcctac 92940 tcgttcggct tcgagggtcc ggcgatgacg gtggacacgg cgtgctcgtc gtcgctggtc 93000 gccctgcacc tcgccgcgca ggcgctgcgc ggcggggagt gcgaccgggc gctcgccggc 93060 ggtgtcaccg tcatggcggg ccccgagacc ttcgtcgagt tctcccgcca gcgcggcctc 93120 gcccccgacg ggcgatccaa gccgttctcc gagtccgccg acggcgtcgg ctggtccgag 93180 ggcgtcggca tgctcctgct ggagcggcag tccgacgcgc tccgccacgg ccaccgcatc 93240 ctcgccgtgg tccgcggctc ggcggtcaac caggacggcg cctccaacgg gctcaccgcg 93300 cccaacgggc cgtcccagca gcgggtcatc cggcaggcac tggcctccgg tgggctgtcc 93360 accgccgacg tcgacgccgt cgaggcgcac ggcaccggca ccaccctggg cgacccgatc 93420 gaggcccagg ccctgctcgc gacctacgga caggaccgcg agcagccgct gctgctcggc 93480 tcggtcaagt ccaacatggg ccacacccag gccgccgccg gtgtcgccgg tgtgatcaag 93540 atgatcatgg cgatgcagca cggggtgctg ccccgcaccc tcggggtcac cgagccctcc 93600 tcgcacgtcg actgggacgc cggggcggtc gagctgctca ccgagcagac gccgtggccg 93660 gagaccgggc gtgcccgccg cgccgggatc tcctcgttcg gcatcagcgg caccaacgcc 93720 cacgtcgtgc tggagcagcc gtcgccggtg gaacccgccg acgcggtcgc cccggcaccc 93780 gcccgggacg gcctggcgcc gctggtgctg tccggcagga cccccgaggc gctgcgcggg 93840 caggccgacc ggttgcgcgc gcacctgcag gaccggtccg gcctcgtccc ggccgacgtc 93900 gcgtcggcac tggcgagcag ccggtcgcgg ttcgcccacc gggccgccgt cctggccgga 93960 gaccgcgacg acgccctgcg cgcgctggcc gcgctcgccg cggacacccc cgacccggcc 94020 gtcgtgaccg ggaccgcccg gcccggccgc accgcggtgg tgttctccgg gcagggttcg 94080 cagcggctcg ggatgggccg cgagctgtac gggcggttcc cggtgttcgc cgaggcgttc 94140 gacgccgtcg tcgcggtgct ggacgccgag ctcggcggtg acctgcgggc cctggtatgg 94200 ggcaccgacg ccgcggcgct ggacgagacc ggcacggccc agcccgcgtt gttcgcggtc 94260 gaggtcgcgc tgcaccggct ggtggagtcc tggggtgtgc gggccgacct ggtggcgggg 94320 cactcgatcg gtgagatcgc ggcggcgcac gtggccgggg tgttctcgct ggccgacgcg 94380 gcgcgcctgg tcgcggcgcg ggcgtcgctg atgcaggcgt tgccgaccgg gggcgcgatg 94440 gtcgccgtcc gtgcgaccga ggagcaggtg cgcccgcacc tgaccgacga cgtggcggtc 94500 gccgcggtca acggacccgc ctcgctcgtg ctggccgggg cacgagacgc cgtcctggcc 94560 gtcgcggaac agctgcgcgc gcagggccgc tcggtcacca cgctgcgggt ctcgcacgcg 94620 ttccactcgc cgctgatgga cccgatgctc gaggagttcc gagccgtcgc cgagcagctc 94680 acctacaccg agccggtggt gccggtggtg tcgaacgtga ccggtgcgct ggcggggccg 94740 ggtcagctgt gcgtcccggg gtactgggtg cggcacgtcc gcgaggccgt ccgcttcggc 94800 gacggggtgc gggcgctggc cgaggccggc gcgaccacgt tcctggagct gggtccggac 94860 ggggtgctct cggcgatggc ccgcgagtcc ctgcccgagg acacgaccgt gacggtcccg 94920 gtgctgcgcc gcgaccgcga cgaggagcgc accgccctca ccgcgctcgc cacgctgcac 94980 accacgggcg tccccgtcga ctggaccgcc ctgctcccgg ccgggccgga ccacgtcgac 95040 ctgccgacct acgccttcca gcaccggcac ttctggccgt ccggagcgac cggcgcaccg 95 100 gccgggaccg ggacgaccgg gcacccgctg gccggcagcg tcgtcgcgct cgccgacggc 95160 gagggcctcg tgctcaccgg tcggatctcg acccgcaccc agccgtggct ggccgaccac 95220 gccgtcggcg gccgggtgct gctgcccggc accgcgttcg tcgagctcgt cctgcgcgcc 95280 ggtgaggagg tcggctgcga ccacgtcgag gagctcacgc tcaccgcacc gctggtgctg 95340 cccgacgacg agaccgtccg gacccaggtc cgcctcgggg cggccgacgc cgcgggccgc 95400 aggcccgtca ccgtccactc ccgcccccac ggcaccgacg acgacccgga ccccgacgcc 95460 gggtggaccc tgcacgccac cggcacgctg gtcaccgccc tcccgccggt cccggacccg 95520 ctcgacggga tctggccgcc cgccggcgcc gaaccggtgg acctcgacgg cttctacccg 95580 gcccgcgcgg ccgagggctt cgcctacggc ccgtccttcc agggcctgcg ggccgcctgg 95640 cggcgcgacg gcgaggtgtt cgccgagctc gccctgcccg aacccgccga cgggaccgcc 95700 acggcctacg ccctgcaccc cgccctgctc gacgccgccc tgcagtcggc atggctggcc 95760 gaggaccggg gcggggacac ggccggcacc accgccgcgg gcgtcccgtt cgcctggagc 95820 ggtgtctcgc tggccgccgc cggtgcgtcc gcgctgcggg cccggctgcg ccgcgacccc 95880 gacggcaccc tcaccgtctc cgcgaccgac accggcggcg cacccgtcgc cgaggtccgg 95940 gcgctggaga tgcggccggt cggtactccc gacgacgtcg cccccggtgt ccgggacgcc 96000 ctgttcggcc tcgactggac ccccgtcccc gatgccggac cgctccccga cgccaccacg 96060 gccgtcctgg tcggggacga tccgttcgac ctgaccggcg cactggccga gctcggcgcg 96120 accgtcgagc accacgacga cctgccggcc ggaacgcccg ccggaccggt gctgctgccc 96180 gtcgccgcgc ccgcggaccc cggcggcgag gacgccgccg cagcggccca cacgctcacc 96240 gcccgggtgc tcggcctggt ccgcgcccgc ctggagcagg agcgtttcgc cgggacccgc 96300 ttcctggtcg tcacccgcgg cgcgacaacc gggcacgacc cggcggcggc cgcggtgtgg 96360 ggcctggtcc ggtcggcgca gtcggagaac cccggcgcgt tcggcctgct cgacctcgac 96420 ccgcacgccg cggccacgct gccggccgcg gcgctgggcg gcgacgagcc gcagctgcgc 96480 acccacggcg gggagctgcg ggcggcccgc ctggcccgcc gcgcacccgc cggcgacgac 96540 accgcggccg ccggcctcgg cgccggcacc gtcctggtga ccggcggaac cggtggtctc 96600 ggcgccgtgc tcgcccgcca cctggtggcc gcgcacgacg tgcgtgagct gctgctggtc 96660 agccgccgcg gcccggacgc cgagggcgcc gccgacctcg tcgccgacct ggccgacgcc 96720 ggggcacgcg ccaccgtcgt cgcctgcgac gtgtccgacc gcgacgcggt caccgcgctc 96780 ctcgacgacc acccggtgca cgcggtggtc cacgccgcgg gcgtgctcga cgacgggctg 96840 gtcgcgacgc tgacccccga gcggctcgcc gcggtgctcc gcccgaaggt cgacgccgcc 96900 tggcacctcc acgaggcgac ccgcgaccgc gacctcgcgg cgttcgtgat gttctcctcg 96960 gtcgccggag tgctcggcaa cccgggacag gcgaactacg ccgccggcaa cgcgttcctc 97020 gacgccctgg cgctgcggcg ccgcaccgag gggcttcccg gcaccgccct ggcctggggc 97080 ccctgggagc agggcatggc gggagagctg accgaggccg aggcggcgcg cctcgcgcgc 97140 tccggggtcc cggcgctgac cgtcgagcac ggactcgccc tgttcgacgc cgccctggcc 97200 accggcgaac cggcgctcgc gccgatgcgt ctcgacccgg ccgcgctgcg tgcccacggg 97260 gaggtgcccg cggtcctgcg ggcgctggtc cggggccgct cccgccgcgc cgcggtcgcc 97320 ggctcggccg ccgcctcggg gctgcgtgac cgtctggccc cgctcacccc cgaggagcgg 97380 cgcgaggtgc tcctcgacct cgtccgcggc caggtcgcgc tggtcctggg ccacgcgggc 97440 gccgccgacg tcgacgccgg gcgcgcgttc cgcgacctcg gcttcgactc gctcacctcg 97500 gtggagctgc gcaaccggct caacaccgtc accgggctgc gactgcccgc cacgatggtc 97560 ttcgaccacc cgaccgtcga cctgctggtc gacgtgatcg ccgacgacct gttcggcacc 97620 gacgacgacc tcccggccgc cccggtgcgg accgccgcgg tcgccgacga cccgatcgtc 97680 atcgtcggca tggcgtcgcg ctaccccggc ggtgtcgcca ccccggacga cctgtggacc 97740 ctggtcacct cgggcggcga cgcgatcacc gggttcccca ccgaccgagg ctgggacctg 97800 gagaacctct accaccccga cgccgaccac ctcggcacct cctacacccg cgagggtggc 97860 ttcctgcacg acgccgccga gttcgatgcc gggttcttcg ggatgagccc gcgggaggcc 97920 accgcgaccg acgcgcagca gcggctgctg ctggagacga gctgggaggc ggtcgagagg 97980 gccgggatcg acccggtctc gctgcgcggc agcgcgaccg gtgtgttcgc cggggtcatg 98040 tacagcgact acggcacggt gctcgccggg cccgagtacg agggcttcca gggcagcggc 98 100 agttccccga gcgtcgcctc gggccgggtg tcctacaccc tcgggctgga gggcccggcg 98160 gtcaccatcg acaccgcgtg ctcgtcgtcg ctggtcgcga tgcactgggc gatgcaggcc 98220 ctgcgctcgg gggagtgctc gctcgcactc gccggcggcg tgacggtcat gtcgaccccc 98280 ggcgtgttcg tcgacttcgc ccgccagcgc ggcctgtccc cggacggacg ctgcaaggcg 98340 ttctccgacg acgccgacgg cgtcggctgg gccgagggcg ccggcatgct ggtgctggag 98400 cggcagtccg acgcgctccg gaacggtcac gagatcctgg ccgtggtgcg cgggtcggcg 98460 gtcaaccagg acggtgcgtc caacggtctc accgcgccca acggcccgtc gcagcagcgc 98520 gtgatccgcc aggcactcgc cagcggtggg ctgtccaccg gcgacgtcga cgtcgtcgag 98580 gcgcacggca ccggcaccac cctgggcgac ccgatcgagg cccaggcgct gatcgcgacc 98640 tacgggcggg accgcgacac cgaccggccg ctgctgctcg ggtcggtcaa gtcgaacatc 98700 ggccacaccc aggccgccgc cggcgtcgcc ggtgtgatca agatggtgca ggcgatgcgg 98760 cacggcaccc tgccggcgac gttgcacgcc ggtgtcccct cgtcgcacgt ggactggtcc 98820 gacggcacgg tcgcgctgct caccgagcag agggcgtggc cggagaccgg gcgggcccgc 98880 cgggcggcgg tgtcgtcgtt cgggatcagc ggcaccaacg cccacgtgat cctggagcag 98940 ccggccacgg acgcatccgg gccggtcgcg acccccgacg gcaccgacca cgaccgggcc 99000 gtgccctggg tgctgtccgg ccgcacgccc gaggcactgg ccgggcaggc cgggaagctg 99060 gccgaggcgc tggaacggcg ccccggactg cggcccgccg acgtcggtct gtccctggcg 99120 accggccgca cgctgttcga ccaccgcgcc gccgtcctgg ccgccgaccg cgaggaggca 99180 ctgcgcgggc tgaccgcgct cgccgcggac ctcccggacc cggcggtcgt caccggggcc 99240 gtccggagcg gccggaccgc ggtgctcttc tccggtcagg ggtcgcagcg gcccggcatg 99300 ggccgtgagc tccacgaccg gttcccggta ttcgccgagg cgttcgacgc ggtcatggcc 99360 gcgctggagg ccgagctggg ctcggacctg cgcccggtcg tgtggggctc cgacacgaag 99420 ccgctggacg agaccggggc ggcgcagccg gcactgttcg cggtcgaggt cgccctgttc 99 480 cggctggtgg agtcgtgggg gatcaccccc gacgtcctgg ccgggcactc gatcggcgag 99540 atcgccgcgg cccacgtggc cggggtgttc tccctggccg acgccgcgcg gctggtcgcg 99600 gcgcgggcgt cgctgatgca ggcgctcccg gcgggcggcg cgatgatcgc cgtccgcgcg 99660 accgaggacg acgtggcccc gtacgtcacc gaccggctgt cgatcgcggc ggtcaacggc 99720 ccggagtcgg tcgtcgtctc cggcgacgag cacgccgtcc gcgaggtggc cgcccggttc 99780 accgccgacg ggcaccgggc caccgcgctg cgggtgtcgc acgcgttcca ctcgccgctg 99840 atggacccga tgctctccga gttcggggcc gtcgccgccg ggatcaccta ccgcgaaccg 99900 tcgatcccgg tggtgtcgaa cgtgaccggc gcgctcgccg ggccggggga gctgtgcgac 99960 cccgggtact gggtgcgcca cgtccgcgag accgtccgct tcgccgacgg cgtcaccgcc 100020 ctgcagggcg ccggcgtcgg caccttcctg gagctcggac cggacggcgt gctgtccgcg 100080 ctggtcagca gccagacggc cgacggcgtc gtcgtcccgc tgctgcgcaa ggaccgcccc 100140 gagccgggcg cggcgctcgc cgcgctggcc cggctgcaca ccgcgggcac ggacgtcgac 100 200 tggccggcgc tgctcaccgg cggacgccgg gtcgagctgc ccacctacgc cttccagcgg 100260 gagcggtact ggcccgccgg gccgctcggc gggacggccg acctgagggc ggtcgggctc 100320 ggcgcggccg ggcacccgct gctcggcgcc gccgtcggcc tggccgccga cgacggatgc 100380 ctgttcaccg ggcggatgtc gctgcgcacc cacccgtggc tggccgacca caccgtcgcc 100440 ggccgggtcg tcgtgccggg caccgcgctg ctggagatgg ccgtgcgtgc cggcgacgag 100 500 gtcggctgcg accgggtcga cgagctcacc ctcggcgccc cgctggtcct gcccacctcc 100560 gggtcggtgc aggtccaggt cgccgtcgag gcacccgacg aggccggacg ccgcaccgtg 100620 ggtgtctggt cccgctccgg tgacgacggg acctggaccc ggcacgcgac cggagcgctc 100680 agcaccgccg ggagccccgc cgttggcgag gtgacgaccg aatggccgcc cgccggggcc 100740 gagccggtcg aggtccaggg ctgctacgac gccttcgccg acgccggatt cggctacggc 100800 ccggtgttcc gcggcctgcg tgcggcctgg cgccgcggcg aggagctgtt cgccgaggtc 100860 gcgctgcccg aggagacggc cgggtccgcc gacgcgttcg gcctgcaccc ggcgctgctc 100920 gacgcggcgt tgcacacctc cctgctcacc gggctcggtg acggcgggac ggcggcgctg 100980 cccttctcct ggcagggcgt gtccctgcac cgctccgggg ccacggcgct gcgggtgcgg 101040 ctcgccccgt ccggcgccga cgcgatgtcg gtgcgggcga gcgacccggc cggggcaccg 101100 gtcgtcaccg tggactcgct ggtcacccgg gccgtcgccg ccgacgcggc gacccacggc 101160 gtcggtgacg cgctgttcga ggtcacccgg cagcccgtcg cggccaccgg ggcaccgcgc 101220 acggtcgcgg tgctcggtga ggaccccctc ggtctcgccg gcccgctcgc ggacgcgggt 101280 gtgcccgtcg gcaccggcac cgatgtcgcc gtgatcgccg cgcgcgacga ggtcccggag 101340 gtggtcgtcc tcggtgtgga cggcgccggc gacccggtgt ccggtaccca ccggaccacc 101400 gccgaggtcc tggggacgct gcaggaatgg ctccggcacg acgcactcgc cgggtcccgg 101460 ctggtcgtcg tgacccgggg tgcgaccgac ggcagcgacc tcgcggccgc cgccgtcgcc 101520 gggctggtgc ggtcggcgca gaccgagcac cccggcgccg tcggccacct cgatctcggc 101580 ggtgacggca ccgtcgacgc ggacgccctc gcctcggctc tcggctccga cgagcctgcg 101640 ctgacgctct ccggcgcgga gatccgtgcc ccccgcctca cccggctgcc cgtcgggggc 101700 gacccggccg tctggaatcc ggacggcacg gtgctggtca ccggtgggac cggcggcctc 101760 ggcgcgcagc tcgcgcgcca tctggtcgag gtccacgggg tccggcacct ggtgctcgcg 101820 agccgccgcg gggccgacgc ccccggcagc gccgtgctcg tcgacgagct caccgcccgc 101880 ggcgcctcgg tgtccgtgcg ggtctgcgac gtgtccgacc ccgccgcggt caccgctctc 101940 gtcgccgacg ccggcgcgga ccggtcgctg accgcggtcg tgcacaccgc gggcgtcctg 102000 gacgacggtg tgctcgcctc gctcaccgcc gagcggctcg gcaccgtgct ggcgccgaag 102060 gccgacgcgg cctggtacct gcacgaggcg acccggcacc tggacctcga cgcgttcgtc 102120 gtgttctcgt cggtggcggg cgtgctgggc ggcgccggac aagcgaacta cgccgcgggc 102180 aacgccttcc tcgacgccct cgcggcgcac cgccgtgccg cgggactgcc cggtctctcg 102240 ctggcctggg ggccgtggga gcagggcagc ggtatgaccg gcaccctcga cgacgccgag 102300 gccgcgcgcc tggcccgttc cgggatgccg ccgctgtcgg cgcaggacgg cctgtcgctg 102360 ttcgacgcgg ccctggccgt gagcggcacc gccgacggtc cctcgctcgt cgctccggtg 102420 cggctggaca ccgcggcgct ggcggagtcc ggtgaggtcc ctgcgatcct gcgcggcctg 102 480 gtccggaccc gcacccgccg cgccgcggcc ggcggtgcgg cgaccgtcgc cggcctggtg 102540 gaccggctcg tggccctcgg gcccgacgtg cgtcaccggg agctcctcga cctggtccgc 102600 acccggatcg cgatggtcct ggggcacgcg gacccggccg tggtcgacga gcgggcaccg 102660 ctgcgcgacc tcgggttcga ctcgctcacc gcggtcgagc tccggaaccg gctgagcacg 102720 gccaccggcc tgcggctcac cgcgaccctg gtgttcgacc acccgaccgc caccgcgctc 102780 gccgagcacc tgcacgagga gctgttcggc gccgacggag tagtgccggc ccccgtcgcg 102840 gccccggccg cggtcgccga cgacccggtc gtcgtcgtcg ggatggcgtg ccggttcccc 102900 ggcggggtgt cctcgccgga ggacctgtgg cggctgctcg acgacggcgt cgacgcggtc 102960 tccgggttcc ccacgaaccg gaactgggat ctcgggtcgg tctacgaccc ggaccccgac 103020 cacatcggca cctcctccac ccgccacggt gggttcctgc acgacgccgg tgggttcgac 103080 gccggtttct tcgggatgag cccccgtgag gcgacggcca ccgacgccca gcagcggctg 103140 ctgctggaga cctcctggga ggcggtcgag cgggccggga tcgacccggt ctccctgcgt 103 200 ggcagcgcca ccggtgtgtt cgccggggtc atgtacagcg actacggctc gatcctgggc 103260 ggccgggagt tcgaggggct ccagggccag ggcagctcgc cgagcgtcgc ctcgggccgg 103320 gtgtcctaca ccctgggcct ggagggcccg gcggtcaccg tcgacaccgc gtgctcgtcg 103380 tcgctggtgg ggatgcacct ggccgcgcag gcgctgcggg cgggggagtg cacgctggcc 103440 ctcgcgggcg gcgtgacggt gatgtcgacg ccgggcacgt tcgtcgagtt ctcccggcag 103500 cggggcctgt ccccggacgg gcgctgcaag gcgttcgccg acgccgccga cggcgtcggc 103560 tggtccgagg gcgtcgggat gctggtgctg gagcggcggt ccgacgcgct gcggaacggt 103620 cacgagatcc tggcggtgct gcgcgggtcg gcggtgaacc aggacggtgc gtcgaacggg 103680 ctgaccgcgc cgaacggtcc gtcgcagcag cgggtgatcc gccgggcgct ggcgaacgcc 103740 ggcctgggtg tgggtgacgt ggacgtggtg gaggcgcacg gcaccggcac gacgctgggt 103800 gacccgatcg aggcgcaggc cctgatcgcg acctacgggc gggaccggga catcgaccgg 103860 ccgctgctgc tgggctcggt gaagtcgaac ctgggtcaca cgcaggccgc ggccggtgtg 103920 gcgggtgtga tcaagatggt gctggcgatg cggcacggga cggtgccgcg cacgttgcac 103980 gtggacgcgc cgtcctcgca cgtggactgg tccgacggca cggtcgcgct gctcaccgag 104040 ccgacgccgt ggccggagac cggccgtgcg cgccgggcgg gtgtgtcgtc gttcggcatc 104 100 agcggcacca acgcccacat cgtgctggag cagcccgtcg ccgtcgccga gcccggcgag 104160 cctgccgagc ccgaaccccg cgtggtgccg tgggtgctgt ccggccggtc gccggaggca 104220 gtgcgcgccc aggcggcgcg gctgcgcgac gcgctcaccg agcagcccgg cccgcgccgg 104 280 gtcgacgtgg cccacgcgct cgcgaccacc cggtcggagt tcgcccatcg cgccgtcgtc 104340 ctggccgggg ccggtcccga tccgctcgcc gcgctcgacg cggtcgcctg cggccgcccc 104 400 gacccggcgg cggtcaccgg ggagagcgac ggcggccgca cggccctgct gttctccggg 104460 cagggttcgc agcgtcccgg catgggccgg gatctctacg cccggttccc ggtgttcgcc 104520 gaggcgttcg acgcggtcgt cgccgcgctg gacgccgagc tggagccggc agacggcggc 104580 acgctgcgcg aggtgatgtg ggctgccgac aacggggagt ccggtcgcct ggacgagacc 104640 ggctggaccc agcccgcgct cttcgcggtc gaggtcgcgg cgcaccggct cgtggagtcg 104700 tggggtgtgc ggccggacct ggtggccggg cactcgatcg gcgagatcgc cgcggcgcac 104760 gtggccgggg tgttctcgct ggccgacgcg gcccgcctcg tggcggcgcg ggcccgtctg 104820 atgcaggcgc tcccgaccgg cggcgcgatg atcgcggtgc aggcgagggc ggacgaggtc 104880 accccgctgc tcaccggtga cgtcgcgatc gcggcggtga acgggccggc ctcggtggtg 104940 gtgtccggca ccgaggacgc cgtgctggcc gtcgggaccc ggctcgccga gcagggcagg 105000 cggaccacca ggctgcaggt gtcgcacgcg ttccactcgc cgctgatgga cccgatgctc 105060 gaggggttcc gggcggtcgc cgagcggctg acctatgccg agccggtggt gcctgtggtg 105 120 tcgaacctga ccggtgcgct cgcgcggccg ggtcagctgt gcgatccgga gtactgggtg 105180 cgtcacgtcc gcgagaccgt ccgcttcgcc gacggtctcg cgtcgctgga cgccgcgggc 105240 gtcaccgcct acctggagat cggaccggac ggggtcctgt cggcactggc cgcacagacc 105 300 gtcccggagg gcgccgtcac ggtgcccctg ctgcgccgcg accgcgacga ggagacgacc 105360 gcgctcaccg cgcgggcgca gctgcacgct gccgggcgca ccggcggctg gcacgacctg 105420 ttcaccggga cccggccggc ccgtgtcgac ctcccgacgt acgcgttcca gcaccagtgg 105480 ttctggccgg cggcccggac cgcggacggc gacgtccgcg cggccgggct cggcgcgccc 105540 gagcacccgc tgctcggcgc cgccgtggag ctcgcgtccg gcgggggagt ggtgttcacc 105600 ggacggctgt cccgcggctc gcacccgtgg ctggtcgacc acacggtgct ggggcacgta 105660 ctggtccccg gcacggcgct gctcgacatg gcgatccggg ccggtgacca ggtcggatgc 105720 gaccgggtcg aggagctgac cctggccgcc ccgctggccc tgcccgagca gggggccctg 105780 cagctgcagg tgaccgtcga cgcgccggac cccgacggga accgggccat cggcatccac 105840 tcccggccgg agggcgcggg cgaggacgcc tggacccggc acgcggccgg tgcgctggcg 105900 ccggccggtc ccgccgcccc cctcggggcg gacgcggcgg tgtggccgcc gccggacgcc 105960 gtcgagatcg acacggaggg ctgctacgac accttcgccg acgccggctt cgtctacggc 106020 ccggtgttcc gcggcctgcg cgcagcctgg cgccgtggcg aggagctctt cgccgaggtc 106080 gagctccccg acggcgccgg tggcaccgac gggttcggcc tgcatccggc cctgctcgac 106140 gcggcactgc acgtgtcgct gctggcggca ctcgcttccg acggcaccgg cggcaccggc 106200 ggcggggcgt tgcccttctc ctggtccggg gtgtcgctga tggccggcgg agccgcagcc 106260 ctgcgggtgc ggatcgcgcc gagcgcggac ggtgtcctgt cggtgcgggc cgtcgacggg 106320 gccggtgcgc cggtcgtgac cgtcgaggcc ctgcacaccc ggcaggtcgg cgccgaacag 106380 ctgcgtgccg cccggaccga ccgtgacgcg ctgttcgggc tggactggac ggtcgtcgac 106440 gccgcggagg gggccgctcc cgtggtcgcc gtcctcgggg ccgacccgtt cgggctggcc 106 500 ggggcggtgc cggacgccgt gcaggtcgac gacctggcca cactcgtgtc ggccacggac 106560 ccggtgccgg acgtggtgct gttcccggtc gcggccgagc cgggcgtcac cgggcggccc 106620 gaggaggtgc gcgcctgcac cgtccgggtc ctggagcagc tccagcggtg gctcgccacc 106680 gaggagctcg cgacggcccg gctggtggtc gtcacccgtg gcgccgtcac ggtggacgac 106740 ggcggtgtcg gcgacctgcc ggccgccgcg gtccgtggtc tggtccggtc ggcgtcccac 106800 gagaacccgg gcaccttcgg gctgctcgac ctcgacccgg acgcagccgg cacggatttc 106860 tccgggttgg ccgcggcgct gaccgcgctc gccaccgagc ccgagctggc ggtgcgcgac 106920 ggcgcgctgc gcgccccgcg cctggcccgg atcgccgcga cgcacgagca gcccgatgga 106980 tccgacgcgc gcccggccct gcggaccgac ggcaccgtgc tcgtcaccgg cgggaccggc 107040 gggctcggca gcctggtcgc ccggcacctc gtcaccggac gcggtgtgcg ggacctggtc 107 100 ctcgccggcc gccgcggacc gtccgcaccg ggcgcggcgg agctcgtcgc cgacctcgag 107160 gcgctcggcg cccgggtccg ggtggtggcc tgcgacgtcg ccgaccgcga cgccgtggcg 107220 gcgctggtcg ccgaggccgg gcgggagcgt ccgctgcggg gcgtcgtgca caccgccggt 107280 gtgctcgacg acggcgtgct cggctccctc gacgcggccc ggctcgacac cgtgctgcgg 107340 cccaaggccg acgccgcgtg gcacctgcac gaggcgaccc gggacctgga cctcgacgcg 107400 ttcgtgttgt tctcctcggt cgcgggtgtg ctcggcggcg ccgggcaggc caactacgcg 107460 gccggcaacg cctacctcga cgcgctggcg gcgagccgcc gcgccgacgg gctcgcgggg 107520 ctgtccatgg cctgggggcc gtgggagcag ggcagcggca tgaccggaac cctgggcgag 107580 gccgaggcac agcgcctggc ccgctccggg atgccgccgt tgcccgccga gcagggcctc 107640 gagctgttcg acacgctgct cgcggccggc tccaccggcc gggcgctggt cctgccggtc 107700 cgcctcgacc tggccgcgct gcgcgcgctc gacgaggtcc cggcgctgct gcggggcctg 107760 gtccggacca cgccgcggcg gaccgccgcc gcgggcaccg caccggacgc cgacgcgctc 107820 gtccgccggc tcgccgggct cggtgcccca gagcaggacg agatcctgct cgcgctcgtg 107880 cggggcgggg ccgccgacgt gctcgggcac accgacgcca ccgcggtggg ggtccgtcag 107940 cagttccagg aactggggtt cgactcgctc accgcggtcg agtaccggaa ccggctcaac 108000 gcagccaccg ggctgcggct gcccgcaacc ctgctgttcg acttcccgac cccggccgag 108060 gtcgtgcggc atctgcggag caggctcgtc gtcgccgagc ccgcgggcgc cgacgccgtc 108 120 ctcgccgcgc tcgacggcct ggagcgggcc atcgcgggcc tgcacgtcga cgacgagggg 108180 gagcaccgcc gggtcgcggg ccggatcgag gtgctgcgga ccaagtgggc cgggctgcac 108240 gccgaggacc ggccgtcgga ccccgacggc gacggcgccg gggacgacac cctcgacgac 108300 gcctccgacg acgacatgtt cgccctgctc aacgacgagc tcgggctcgg ctgaggtgcc 108360 tcccgggggg gcgggccggc cggcgcggtc gtcccgcccc cgaggccagg actagggatt 108420 caccggccgc ggtgccggtt cactggctac gtcgtccggc agcacgccgg gtgcgtccgc 108 480 gaggaaggaa ccccatgacg acgaccgcca ccgaggagag cctgtgggtc cggtgcttcc 108540 acccggcacc ggagcggccc gtgcagctcg tctgcttccc gcacgcgggc ggttcggcct 108 600 cgttctactt cccggtctcg gcgcagctgc agaccaccgc ggaggtgttc gccgtgcagt 108660 acccgggccg gcaggaccgg cgccgcgaga ccagccccgg tgacctccac accctcgccg 108 720 accaggtcca cggcgcgctg cgggactcgc tgcggggcca ccgccctacg gtcttcttcg 108780 gccacagcat gggcgcgacc ctggcgttcg aggtcgcgcg gcggcacgag gcccagggcg 108840 ggcggatcgc ccacctgttc gcctccggcc ggcgcgcacc ctcgcgtgtc cgtgacgagc 108900 acgtgcaccg gctgagcgac gagcagatcg tcgaggagct gaagctgctg gcgggtaccg 108960 acaccgcgct gctcggcgac gacgagatcc tccggatgat cctgcccgca atccgcagcg 109020 attacgaggc gatcgagacc taccgctgca cgcccggggc caccgtggcc gcgccgatca 109080 ccgtcctgac cggggacagc gaccccaaga cctcacggga cgaggcggag tcctggcgcg 109140 accacacctc cggaccgttc gatctgcacg tccgtccggg cgggcacttc ttcctcggct 109 200 ccgacgcccc ggcgatcatc gccatgctgc gcacggtcct caccgcgtcg tcctgatccc 109260 gcaggagcga gcgcggtcac cgtaccgaca cgcggcggcc ggtatccggc acgggtggga 109320 tctcctaggc tcaagatcgt cgagccgggt ccgcccggcc gggaccggtc gctcgtggag 109380 gtagcccagg atgtccgatg ccaccgatcg cggcgtgcgc ctggtgggtc gggggtccga 109440 gtcggcgtgg ctggcctcgg ccggtgccgg cgccgccgcc ggatcacacg tcgtgcggct 109500 gctcgtcgga ccgcccggga tcggcaagtc ggtgctgctc gacggcttct gcaccgaggt 109560 cccggcgggc gtgcgggccg cccgtgccca tgggcgggaa cggacctcgg acatctcgtt 109620 cgccgtggtc cgggagctgt tcggggccct ggccggcgcg ggcccggtcg acccggcgct 109680 gctcgagggc ggtgcccggt ggagtgcacc ggcgctggac gaggcgacgg gcggtgccgg 109740 accggacaac ctctacccgg tgctgcacgg cctctactgg ctcaccgtga accacaccgc 109800 tcgcggcccg ctggtcctcg tcgtcgacga cctgcagtgg tgcgacgacg cctcgctggc 109860 cttcctcggg ttcctgctgc gccggtcgga gggtctcccg ctcggggtgg tgctcgcctc 109920 gcggaccgac ggagcgggcg cactgcccga ccggctcgcc gagatccgca cccaggccgg 109980 tgcggcggtg accgaggtgg gcccgctgga ccggtccggc gtcgcccggc tcgccgtggc 110040 ccgcggtgcc ggtacgggag ccgagccgcc gcaggcgccg ttgctcgacg cgctcaccga 110 100 ggcctccggc gggaacccgc tgctggtcga gcagctggtc gccgagctgg gcccggtgac 110160 cggcgacggc gcgaccgacc ggatccaccg gctcgggcgc gaggtggtcg acggtctcgt 110 220 ggaacggcac gtgttcgacg ccccgccgca cgtccgcgcc gtggccgccg ccgtcgcggt 110 280 cgtgggtgcc gagcagacca cggtcctcgc gaccctgtcc ggggtgcccg ccgggtcggt 110340 ggccgacgcg gtcgcgacgc tcgtccggac cgaggtcttc gcccccgacc ggtcggactt 110400 ccggcacgac ctgctgcgca ccgcggtgtt gcgtggactc cccggggacg agctcgacga 110460 cctgcgccgg cgcggcgccc gggtgctgag cgacgcgggg cgcccggccg aggtggtggc 110520 ggcggtcctg ctcgtcctgc ccggcgccgg cgagccctgg atggtcgacg tgctgctgga 110580 ggccgcggcc gccgcggcgc accgcggtgc ccggcccgcc gtcgcccgct acctggaacc 110640 ggtggtcgcg gcccgacccg acgacgtggg cgcgcggacc cggctggccg cggcgctggc 110700 ccagcacgag ccggagcgtg ccgtcgcgca gctgcgcgac gcgctcgacc gggccgtgga 110760 cctgccctcg cgtgcccagg ccgccgtgca gctggccatg acctcgctgg cggtgcagca 110820 ggccccccgt gcggtgcggg tgctgcagga cgtcctggac acgatggacc gcgagttccc 110880 ggccgacccc ggtcccgagg cgaccgagct gcgcacgcac gtggaggccg cgctgctggt 110940 cgtcgggctc gacgagaaga agaccgtggc cgcgacgatc gaccggatgg gacggatggc 111000 ccggcccgcc ggccgcactc ccgccgagcg ccagaagctc gcgatgatga cggtgaccct 111060 ggcgatggac ggtgacgacg cggccgcggc cgtggacctc gcgcgccggg tgctcctggt 111120 cgacgaggcc accctcggcg gctgggcggt gctggcctcg tcgctggtgc tgcggctggc 111180 cgacgaggtg gaggagtcga cagcggtgct cgaccggctc gtcgtgcaga gccgcgagca 111240 ggcctcggcg tggacctaca gcctcgccgt ggggacccgc gcgaccaacc acgtcgtcgt 111 300 cgggagcctg gccgagggcg aggccgacgc ccgcacggcg ctcgacatcg ccgagcagga 111360 ggcgtggcgg gggaacaccg tggtgccgac gatcgcactg gcgaacgtgc gccagcagca 111420 gggcgacccg gaggcggcgc tcgagctgct cgacgggatc gtccggcccc ggctcgagga 111 480 cttcgcctgg gagtaccacg actacctgat ggcgcgggcg ggggcgaccg ccgacgtcgg 111540 cgacgtcgac cgggccctgt cgacctaccg ccgctgcggg gacagcctcg acgcggccgg 111600 tatcgcgaac cccgtcctgg cgccgtggtg ggtgcacgcc gccgtcctgc tcgccgacac 111660 cggccgggcg cacgaggcac acgggatcgt cgagggaggc gccgaacggg cggcgcgctg 111720 ggggaccggc cgcgggcggg ggctcgcgct gctggcccgc ggtgtggtca ccgccggtcc 111780 gcgcggcgag gacatgctcc gggaggcggt ggaggtgctc gagggctcgc ccgcccggac 111840 cgagctgatc ctcgcccacc acctgctggg ccgggcgatg ctggtgtccg accacgccga 111900 ggacgcccgc gagcagctgc gccgggcggc gaccctggcc gcccggtgcg gggcgctgcg 111960 ggcggcccgg gtcgcccggg aactgctcgt gcaggccggt ggccggatgc gtccgcccac 112020 cggctccccg ctggacccgc tgaccggtgc cgaacgccgg gtggtcgccc tcgccgccga 112080 gggcgcccgc aaccgcgaga tcgcggaggc gctgttcgtc acgctgcgca ccgtggaggt 112140 ccatctcacc agcgcgttcc gcaagctcgg cgtcaccgac cgggccgccc tggccgggat 112 200 cgtcgatgcc gcccgggtcc gcagcgcatg atcgacggcg tgttgcgcga acgggacgcc 112260 gcctgcgccg agctcgaccg cgccctcgac gcgctggtgg cggggggatc gccgttcgtc 112320 gcgatcaccg gcgagcccgg tacggggcgc tcggccctgc tccgccgtgc gtcggggcgt 112380 gccgccgacc gcgcggtacg ggtgctgtcc gcgcgggccg tccccaccga gaccgggtgc 112440 ccgctcgcga cgggccacgg tctggtcgag cggctcggcc cggtacccgc gccgccccgg 112500 tcggggccgg tgggcgccga cgtcctgcac gagtggtgcc gtgctgtgct cgacctcgcc 112560 cgcaccggcc cggtgctcct ggtcgtcgac gacctgcact gggccgacga ggacacggga 112620 cagtggctgc agatgctgct ccggcgacgg cgcgaggcgc cggtcggcct tctggtcgcc 112680 ctgaacggca cgcacgacgg tctcggctgg gccgtctcgc cgaccggccc gtcggacgtc 112740 gtgctgcgga cggggccgct ctccctcggc gcggtgcggg aggtggtcac cgccgagtac 112800 ccgacgcctc ccgaccgcgc tttcaccgtc ctcgcccgtc gctgcaccgg cggcaacccg 112860 gcggtgctgc gggcgaccct ggccgggctc gaccgcgcgg tgcccccgac cgcggccgcc 112920 gtgccggagc tggtgcgtcg cgcggccacc gcccggcgcg accacgtcgc ccgggtcctc 112980 gacgggctgc cccccgccct ggtcgaggcg ttgcgcgcgg cggcggtgtg cggatccgag 113040 ctgcagccgg tgcgacaccg ggtcggcggc cccgtagcgt ccaccggtgc cggggcccgg 113100 gcagcgctgg ccgccaccgg cctggtccgc ggcaccgacc acgcgctgcc cgccgaccgc 113160 agcgtcaccg acgtcgtcct ggccggcatc gagccggggc accggagggc gctgttcggc 113220 tccgccgccg gcctcgcggc gcgggccggg ctgcccgagg agcgcatcgc ccgcgccctg 113280 ctcgacgctc ccgcgctcgg cgagccctgg gcggccgagc tcctgcaccg ggtcgcggtc 113340 cggcaccggg ccgaggaccg gcccgccgac gccgccgcgg ctgccgagcg cgcgctgcag 113400 gagcccctgc cggacccgct ccgcggggcg ctgctggtgg agctggcgct gtcgcgctcg 113460 cacaccgcgc ccggtacggc cgcgcgggtg ctctcccgga tcaccctgga caccgacccg 113520 gcggcgagcc ggtacggggc ccgagcggtc gacctgctgc tgtccgccgg ggaggtcggt 113580 gcggcccggc aggcgctgga catcgcggtc cgtcgatgtc cggaggacgc gccggcgcgg 113640 gcggacctgc tgtcgttgtc ccggctgacc gacgagctcg gcttcgaccg gcggaccgtg 113700 ctgcacggcc cggtcgccac ggcggcagcc ggctccgacg acgacggtcc ggtcgcccgc 113760 gggaccaccg cgtggtcgct ggtcctgcgc ggccgcgacc gggaccgtgc cacccggctg 113820 gcccgcgcca cgctgaccgg cccgagcggc gtcctcccgg cgataccgca ggtggtcgcg 113880 gcgctcaccc tcgacgccgt gggctgtgcc gacgaggcgg gcgaggcgat gcaccacctc 113940 ctgctcgaga tcacccggga gcgcccggtc ccgcccgccg tactcgcggt gtcggcactg 114000 gtcgagctgc ggacggggga cctcgacggc gcacgacggg acctgcgggc cgccgccgtc 114060 gccccggtct cctccgacgg gcccgacccg ctcgccgggg ccgcccgggt gctggtgcac 114120 ctggcggagc ccgacgtgga ggctgccgac gccgcggcct tcgccgacct cgccgccggg 114180 ggagtacggc ccggtgcggc cctgctggag tacgcgcggg ggcgcgtgcg gtcggtgcag 114240 ggccgccacc gcgacgcggt ggagcactac atggggtgcg gtcggctgct gctggaccgg 114300 ggccgggtca atccggtcct ggcgccgtgg cggtccgcgg cggcgacctc gctgctggcc 114360 tgtgggtcgc ccgcggccgc ccgccggttg gccgccgacg agctccggct ggcgctccgg 114420 tggggcgcgc cggccccggt cgcggcggcc gaggcggtcc tggccgggct ggacgccgag 114 480 cccaccgccg tcggggagcc gctcggggac ggggtggcgc gtgctgcacg gccgtgaccg 114540 ggagctgggc acccctgcgc gacgccgtca cccgggccgc cgacgggagc ggcgcggccg 114600 tcgtcgtcgg cggcggtgtc ggcagcggcc ggaccgccct gctcgacgcg gtgggggtcg 114660 cggcgggcag ggccgggctg acggtgctgc gggccgcctc ggcgctcgtc gagcgcgact 114720 tcgagttcgg cgtcccccgg cagctgttcg acccgctcct cgccgccgcg ggtgcggacg 114780 cccgcacccg gtggctggcg gcgtcccgcc cgaggctgcc cgcggcgctc gcggcggaac 114840 cgctcgaccc ggcggagacc cacgaggagc aggaccgggt gcgcgagctg caggcgctgt 114900 tggcgaccgt gggcgccgaa cggccggtcc tggtgctggt cgacgatctc cagtgggcgg 114960 acacggcgtc gctgcggtgg ctgaaccggc tcgtcgcgcg gatcccggac ctgcccgtgt 115020 ccttcgtcgg caccaccctg cacggcgacc cgggcgccgg gcggccgccg gtacgcggtc 115080 tggccgggtc cgccgtaccg ctgcggtccc ggccgctggg acccgccgcg gtccgcggga 115140 tggtcgccgg gcgcttcggt cgcgcgggcg acccggagtt cctgcaggtg tgcgaggagg 115200 tctcgggagg tgtgccgtcg gtgctgcgcg ccgtgctcga cgaggtcgtc gcggccggcg 115260 gtggcccggt cgcggcgtgc atccccgccg tgcgctcggc ccggccggcc ggcctgcggg 115320 agcgcttcgc ccggtgcctg cgggcacagg acgacgcggc gcgccggtac ctgggcgccc 115380 tggccgtgct cgggcccgcc gccgacccgg cggtcgtggc gcggctggcg gagctggacc 115440 cgcacggcct gcgtgcggtg caggggcagc tgacggaaca gggtctgctc accgacgacc 115500 acaccgggtt cacccacccg ctggtccgcg acgtcgccgc cgaccccgcc gagcgcgagc 115560 ggctgcacct gcgcgcggcg cggctgctgc acgagaccgg gcaccacgcc caggaggtgg 115620 ccgcgcacct gctcgcggtc gccgccccgc tcgacggctg ggccgtcgag gtcctgcggg 115680 ccgcggccca ccagacgacg accgcgctcc gcccggacac ggccgacgac cacgacgacg 115740 acccggtcgc ggtccggtac ctgcgccggg ccctgctcga cagcgacgtg cgtggccacg 115800 agcgcggggc cctgctggtc gagctggccg cggcggagcg gttcaccgag cccggcaccg 115860 ccgtccggca cgtgtcccag gcgctgccgc tgctcgcctc gccgcaggac cgggcggtcg 115920 cgctcaccct gatcgacccg tcgacggtgc gggaggtgcc ggcgcgggtc caggaggcgg 115980 tccgtgcggc cgacgccgga acggacccgg tcgtcgacga cgagtgcacg gtggccgtcc 116040 ggatccgtgc ccgcgcccgg cggctggacg agcagcaccc ggaggggctg gcccggtcct 116 100 gcgcgctgct gcgcgaggtc gtggccgcac cggacgagca cctcagcacc gcggccggtc 116160 gcgagctggt cggcgtgctg ctgcacgccg cggcgctgac cggcggggta ccggcggccg 116220 acgtcgccca cctcggggaa cgcctgctgc ggatcacacc ggcgcgcgag gtgcggcccc 116280 cgcacggcat cccgccgggc gacgggccac gtggcctgct ggtgctcgcc ctcgtcgccg 116340 ccgaccggcc gcggccgctg gaggactggc tggtccccga cccgacatcg cccgcggcgg 116400 ccaccgccga cgagctcgcc ctggtcctgc tggcccgcgg gcggcccgcg gcggcggcgg 116460 cgctgcccgg tggggtcctg cgtgagcgcg gggtccccgc atcggccgcc ttccacaccg 116520 cgctgatcgc cgcggcgatc gaggcccggg cgccggcact cggcccggag cccgccgggc 116580 ggccgcccgg cggtggtctg gtcgcgcacg cgacccacca gctcgtgcgc gcggccggcg 116640 cgctgcgtgc gggccggcag gacctggcgc tggagtgcct gctcgactgc gggcgacacc 116700 tggagcacct cggctggtcc aacccggccc tgttcccgtg gcggagctgg gcggcccggc 116760 tgctgcgccg ccgtggtgcg acgggggccg cgctggaatg ggccgacgag gagctggcac 116820 tggcgcgggc gtggggtgcc cccgccgcac tcgggcgtgc cctgcgggtg cggggctcgc 116880 tcgtcggcgg ggccgcggga gcgacccagc tgagggaggc cgtcgaggtg ctcagggact 116940 cggcggacac ggccgcgctc ggtcgcgccg agatcgtgct ggggcgacac ctcgccggca 117000 cgggcgcccc cgagggcgag gcgctgctgc gtcggggtct gcgccgcctc gaggaggccg 117060 gggccgggga cccggacacc gcgacgccgg taccgacggt cgagccggcg gccggtaccg 117120 gcgacgacgg ggaggagtcc ccagcgtggc gcgtcgtcga cgccctgacc gacgccgagc 117180 ggcaggtggt ggaccgggtg gtcggcgggg cgaccaacaa gatgatcgcc gaggagctgg 117240 gggtcagccg ccgggccgtg gagaaacggc tgaccagcgc ctaccgcaag ctcggggtca 117300 gcgggcgcag tgcgcttcgg ggggcggact gaccgccgct cccggtgccg ggggcggcgc 117360 tcgtcacgtg cgcgcggtcc agctcgcggg cgcctggtac ccgccctggc cggaccagct 117420 cgtcggggcc cggtagccgt ccgcacccgg ccaggacgcg gcccgccggt gccggtgggg 117 480 tgccgcggcg acccggctcc gcccggccag ggtgcacagc gccacggtca cggcggccac 117540 ctcggccggg gtcgggttgc caccggtgat caggatccgc ggtccggggc ccgccgcggt 117600 ggtcacgtcg gcgggttgcc gtgcttgcgg accggcagct cggcgcgctt ggcacgcagc 117660 atcgacagcg cgtcgacgag gaccgcgcgc gtgtcggagg ggtcgatcac gtcgtcgacg 117720 agaccggcct cggcggcgta gtagggatgc atgaggtcgt tgcggtactg cttgatccgc 117780 tgggctcggg cgatctcggg gtcgggcgcg gcggcgatct cgcgccggaa gacgacgttg 117840 gccgcggctt cggcgcccat caccgcgatc tcgttggtcg gccaggcgag ggacaggtcc 117900 gctccgatcg agcgcgaatc catgacgatg taggcgccac cgtaggcctt gcgcaggatg 117960 agctggaccc gcgggacggt ggccgcgcag taggcgtaga gcagcttggc gccgtgccgg 118020 atgatccccc cgcgctcctg gtcgccgccg ggcaggaaac ccggcacgtc gacgagggtg 118080 accagcggga tgctgaacga gtcacaggtg gagacgaacc gggccgcctt ctccgaggcg 118140 tggatgtcga gcaccccggc cagcgaggcc ggctggttcg ccacgatccc gaccgtgtgc 118200 ccgtcgagcc gggccagacc gcacacgatg ttggtggccc agttggcgtg cacctcgaac 118260 aggtcgccgt cgtcgaccac ctcggcgatc acgtcccgca tgtcgtaggc gcgggtggtg 118320 tcggccggga cgatgtcgag cagcgacggg gtggcccggt ccggtgggtc ggcggtgggg 118380 gccacgggcg gctgctcgcg gttgttcgac ggcagcagcg acacgaggtg ccgcacgtcg 118440 gcgaagcagg actcctcgtc gtcgtagacg aaggcgcccg cccccgactc cgtggcgtgc 118500 acctcggcgc cgccgagttc ctcgtgcgtg atctcctcac cggtcacggc ggacaccacg 118560 tccggtccgg tgatgtacat ctgggcgatg tcgcggacca tgaacacgta gtcggtgagg 118620 gcgggcgagt aggtcgcgcc cccggcacac gggccgagca tgacgctgat ctgcgggacg 118680 acgccggagg cccgcacgtt gcggcggaag atgccgccgt aaccggccag cgcggtgacg 118740 ccctcctgga tccgggcgcc cgcgccgtcg ctcaggctga tcaacggtgc gccggcggac 118800 tccgccagat ccatcacctt gtggatcttc gtggcgtgcg cctcgccgag cgaaccgccg 118860 aagatccgga agtcgtgggc gtagacgaac acggtgcggc cgtcgatggt gccccagccg 118920 gtcacgacgc cgtcggtgtg cggacggcgg tcctccaggc cgaagccggt ggcgcggtgc 118980 ctgcggaact gctcgatctc acggaagctg ccctcgtcga gcagcatcgc gaggcgctcg 119040 tgcacggtca gcttgccgcg ggcgtgctgc tgctcggtcg cggcggtgga cgggccggag 119100 cggatctgct cgcgggccgc gtgcagctcg gccacccgcg accgcaggtc cgcggtcgtc 119160 cggatgtcgt cggtggcggt catgttctca cctctcgcct cgggacgtcg tcgggtcgag 119220 cagtcacttc acgtgatcgg gcacgacctg gggcggccac gaacccagct cgaagaaacc 119280 catcgagtag gccttggaga tcagcgcagg ccggttcttg acccgcatct tccggagcag 119340 ggcggtcacg tggtactcga cgccgccgcg gctgaggaac agggtggagg ccagctgcac 119400 ggtggaggca ccggaggcga ccccctccag gatcttggcg tccatgtccg acaggatccg 119460 gcgtggtccg ctccaggccg tggacggctc ggcgtccccg gtacgcagga cgacgacgac 119520 cccctcgacc cggcccgcgt tccgcgcgat cgcggtcgcc atcaggtcgc cccgcagcga 119580 cgagccggcc ccggcgatcg cgaccgaccg ctcctggaaa cggggctgct gaccgtccag 119640 caaccgttcc atctggtgcc ggacacgggt acggatgctt ccgtcgagga ggtcgcagaa 119700 cgccgatccg cacacgtcgc cggaaccgat gtcgcacatc cggcggaaca tctcctggtt 119760 cgccgcgacg acgcgcaggc ctcggtcgag cgataccatg caggcactgg tggattcctg 119820 ggaaatgcgc tcggtggtgt cgccgtcata gggcaggact cgcatcgaat aactccccga 119880 agttcaacgg aacacgctgt tccgggagcg gaccggacag tcgcggtagc cgttctcgat 119940 aaccgattcg accgtatggg ggccgctcga caggggtcaa cggcagcgga gcgtaagcgc 120000 ttaacactgt ggccgccgga gtgcgggggt tcggtggggt gtggtgcggt atgtgatcta 120060 gatcactacg gtgtggggtg tgggtgctgg ggttctgctg gtcccgaccg tggttcgcac 120120 gggtgcgcgc aacgtccgcg ggacaaccgg ggtgcccgtc cgtgcgatgc cgcaacgacc 120180 gctccggcgg caccgggcgt cgcgtcagta ccggacgagg ccggcttcgc gcaggtcgtc 120240 cagccagtcg tccatcatgt cccgcatcgc ccaggggtcg gtgtcccaga ggtcggccag 120300 gtgggcggcc gcgtcgccga ggttccacgc cgtccggcac agcgcgagcc acatggcggt 120360 gccgacctcg tcgcacagca ggcggtcgca ccggctcgga tggcccagct ccatccagcc 120420 ggtatcgagc acccggacgg tcagtcccgg aacgggttcc acgtcgatcc ccctcggtgt 120 480 cggacgggct cggcccacga gtccgggacc ggccacgtcg ccggtccgtc gcattcccga 120540 catgatgcgt tcatgttggc cgtccccgat cgtcatcgag ggaggactat gccgccgatg 120600 tcgcccggat accaccagta tccactgcgt ggatcgaacc cgggcaggtc catggaggag 120660 gaactgggtg tttcccgacg aattccgtgg tggtgctccg ttccacgacg caccggggta 120720 aaatgatcac cgaatcgcgt gcacgtccgt cggacggagg tcgtatgagt gtcgggggcc 120780 caccctgggg agccgtccgt cgggcggacc gcgcggtgct ccgcgagccc gtcgtccgac 120840 tgcggggccg tcgctgatgc cccgtccggt gctgctcggc cgcgccggcg acctggcgga 120900 ggtcgacggc gcgctcgcgc gggccgtcgg cggcacggcg agcctgctcg tgttcaccgg 120960 cccgatcggc atcgggcgca ccgcactgct cgaggagtgc gcgcgccggg gcgccgcccg 121020 cgggatgcag gtcgcgcgag ccgggggcac cgacgaggag ggtggcatcc cgctgggcac 121080 cgcgcgcgaa ctgctcgccg cgtgcggcgg tcccggcccg tcgcccccct gcggagagcc 121140 cgacggggac gacaccggcg ccctctccgc cgcgctcgcc ggtcgcgcgg cggtcggacc 121200 ggtgctcctg ctcgtcgacg acgcggcccg ctgtgacgcc cggtcgctgc gctggctggc 121260 ccgcctgtgc tgcccgcggg cctgcctgcg cgtggcggtg gtcctcacgg tgctcgacgg 121320 cgatgccgga cacgacggcg gtacccgaca cggcggcgcc accgggggac tcccgacgga 121380 gctcgcggcg gtggccgacg cggtgcggcc gctcggtccc ctctcggacg aggcgatctc 121440 ggtgacggcc cgtgcggtac tcgggcggga cgcgaccccg gagctcgtgg ccgcgctgtc 121500 cgcggccacg gaggggaacc cgctccacct cacctgcgtg ctggaggagc tcgctgcccg 121560 gccgcagtgc accacggagc cgccggcgcg ccgggtggcc ggcgccgcgc cggcacggct 121620 gcgggaccgg ttcgcccacg ccgtgcgacg gctgcccgcc accgagcgcc ggtacctcgc 121680 tgcggtcgcc gtcgcggggg agaaggccga cgacgtgatg ctggcccggc tcgccgagct 121740 ggacgcgacc gatctcgccg tggccggtgc tgtcacccgc agcatggggc tcaccgggcc 121800 cgagggccac cggctgcgcc acggcctcgt cggcgccgcc ctcggagtcg tccagtcctc 121860 gcaccagcgc cgcgatctgc acctgcgtgc cgcccggatg ctgcgggacg cgggcgcgcc 121920 gtccgaccgg atcgccgcgc accttctcac ggccggcggg gcggctccgg cctggacggt 121980 cgaggcgctc cgcgacgcgg cggggaccgc ggtgcggcgc ggagagtcgt ggaccgccgt 122040 ccgctatctg cgacacgccc tgctcgccgg accggacgag ccggggcggg ccgccgtgct 122 100 gctcgacctg gcgggcctcg agcgctcgcg cgacaccggg ctcgccctgc gccggatcgt 122 160 ccaggcagtg ccgttgctcg ggtcgctgcg ggaacgggcc gcggcgttgt gccgggtgac 122220 cccgctcgcg ctggagggcg ccgcgccgcc ggtgatcgcg ctgctgcggg gggtggccga 122280 ggagctgggc cggtacgggg gcaccgggga cacagagacc cgcgagctcg ccctccgggt 122340 cgaggcccgt ctgcactacg tcgacaagca cacccgtgcc ggactgtccg ccgccgcggc 122400 ccggctcgac gaactcgagg cactcccgga cgggctaccg atccggaccc cgggggagcg 122460 ggagctcgcc tgcgtcctgc tgcactccgc cgccgtcggc ggacaccggc cggcgagcgt 122520 ggtggccgcc gcctgccggg cggtcctggc ccgtgagccg gcgtcgtcgg accacgtcca 122580 cagcacggtc gggatgctgg tgacctgtct gtgcatggcc gacgcggtcg aggacctccc 122640 gtcctggctg tcggtcgcgc tcgaacaggc gcgggccgag cgcgctccgg tggtcgaggc 122700 ggtgctgcac gccgagctcg ccgcggtcct cgtgtgctcc ggtcgcgtcg aggaggccgc 122760 cgagcaggtg cggtcggcgg tcgagctggt cgacgagctg gccgacgact cgctgctgcc 122820 cgggacggtg ctggccccgg tgctgaccgc ggtgccgcac gggcccgggg cggaccgggt 122880 gctggcccgg tacggcgcga cgccgtcggt ccccccggga ttcggggcct gcctgcagat 122940 gttgcgggcc cgggtggccg ccgaggccgg cgacgcggag accgcgctgg agtactgcct 123000 cgacgccggc cgccggttcg accaggcggg atggaccgcc acccccgtgc cgtggcgtcc 123060 gtgggcggtc gagatcctgg ccgagcgcgg ccgcagggcc gaggcccggg cactcgccga 123 120 gcaggagctg gcgcgggcac gccgctgggg ggcaccggca cagctgggcc gggccctgcg 123180 gatgctcggg cagctgggcg ggaccgaccg gggcgcggaa ctcctcgaac aggcgaccat 123240 cgtcctgcgg acctcggggg accggtcgga ggccgagcgc gcgaccaggg cgctgaccgc 123300 acaccgcgcc ccaccgggac ccggtgacct cccgccccgg accggggacc cggcgggacc 123360 gccgccgcgc ctgcacgaca ccgtcgggac gcccgtaccc ggacaccggc ccacctcccg 123420 tgcctccgcc gcgctgaccc ggtccgagga acgggtcgcg acgcgcgcct cccgcggcct 123 480 gaccaaccac gagatcgccg ctgacctcgc cgtcagcgtc cgggccgtgg agaagcacct 123540 gaccggcgtc taccgcaagc tgggggtgcc gggccgcgcg gcgctccgcc agctccggga 123600 gagtggttcc gatcgtatcg cctgaccggc cggggagcgg cgcaccgccg cccggggacc 123660 ggctggccgc gatgctgcgc cacgaaccgc ccggcgtggt cgagctggcc agggccgtcg 123 720 ccgtgctcga gccggacgcc gatgccggca cccgcgcccg ggtggccggg ctggacgacg 123780 tggcggccgc ccacgccgcg gagcgcctcg tggagctggg tgtgctcgac gggcaccggt 123840 gcgggcacga tccggcccgc accgccgttc tcgaggccgc cggtgcggac cggtgccgcc 123900 gactgcacgc ccgcgccgcc cgggtgctcg acagcgaggg tgcaccgctc gaccgggtgg 123960 ccgaccacca cctggcggcc gggccgcccc gggacggggg cgtggtcgag ctgctgcacg 124020 tcgcggccgc ccgcgcggag cagcgcggtg accgcgtacg ggcgagacgt ctgttggagc 124080 acacgctgac cgggccggtg ggcggccgtc ggcgggccgc actgctggtg gacctcagcg 124140 tcgtcgagcg ggtcgccgcc ccggcgacgg cccgcggcca cctggtcgag gcgctgtccc 124200 tgctgccctg cgcgcgggaa cgggccgagc tgctcgcgcg gacggtcgcc cggtcgcccg 124260 ggggcgcggt ggacctcgcc ccgctgctgg aggacgtcct gcgtgacctg gccgacgcgg 124320 gcacggggac gagcgggcag gaccgtgagc tgcgccagcg gctggaggcg ctggtgctgc 124380 acgccgcctg cgaggacccc tcgggtgccg cccgggtctg ggaatgggtc gcgcggaccg 124440 atcccggcga gctgggggcg ggagccggcg ccgacgtgct gcgcagcgcc cacctgctct 124500 tctccgcgct ggccctgcac accgacgccg cgacggcggc tgcccggacc gccgaggcga 124560 tgcccgcgga cctggaggac gacgcgtacc tgcacccgat gcaggtggcg gcgctcggcc 124620 tgctgtgctg ggccgaggcc accaccggtc tcgacggtgt ccgtcgacgg accctcgacg 124680 ccgcccaccg cacgcaccgg acggacgtcg aggcgttcct gcgcggggtc gacgcgatgc 124740 tgctgttgcg gcgcgggcag gtgcctgcgg cgctcgccgc cgcccgggcc tcgctcgacg 124800 tactgaccgg tgcgacccgg ttgatggtgc tccgcgcggc gacactggcc ctggtcgagc 124860 tggggcggac ggcggaggcg gagcggttgc tcgctccggt cgacgaccgg agcagcgccg 124920 accggacctg gcggtggaac tacctgctcg acgcccgtgc cgcggtcctc gcggcgaccg 124980 ggcggacccg cgaggcgctc gcgctgacgc tggagtgcgg acatcgcctg atggctgtcg 125040 ggatcgtcaa cccggtggtg ctcgactggc gacggcgggc cgtcgagctc caccacgagc 125100 tcggtgagca cgaggcggcg acggcggcgg ccgaggagta cgtcacgctc tgccggctgt 125160 gggggcccga ggggtacggc ggtgcggcgc tacgggtgct ggggctcgtg cagggcgggg 125220 agcggggact cgcgacgctg cattcggccc gtgccgagct cggcgcctcg ccgctggccc 125 280 tcgaccgggc acggtgcacg gtggacctgg gcgcgcggat gcgcgcgcac ggcgccgccg 125340 gcgaggcgcg tgccctgctg cggcacgggc tggagctggc agtcgactgc ggcgctccga 125400 tcctggcggc tcgcgcccgc accgagctcg cggccgccgg cgggcggccg cggcgcggcg 125460 gctcgtcctc cctgacaccg gccgagctcg gtgtcgcccg gctggccgca gggggagcga 125520 ccaaccggga catcgccgcg gtgctgggga cgtcacagcg ggcggtcgag ggacacctca 125580 cgcgggtcta ccgcaaactg gagatcgacg gtcgcgaggg gttggcatcc gcaccgggtc 125640 tgcgggtcgg tacctgtcga ccgggtgggc agggtgacgt cgatgctccg acccgggcgg 125700 tcgcgccacg gccgtag 125717 <210> 2 <211> 224 <212> PRT <213> Pseudonocardia autotrophica <400> 2 Met Ile Glu His Val Leu Pro Gly Arg Val Val Thr Glu Cys Ala Tyr 1 5 10 15 Asp Asp Glu Glu His Pro Gly Glu Gly Leu Phe Pro Gln Glu Arg Glu             20 25 30 Leu Val Ala Arg Ala Val Glu Ser Arg Arg Arg Glu Phe Thr Thr Val         35 40 45 Arg Arg Leu Ala Arg Arg Ala Leu Gly Arg Leu Gly Arg Ser Pro Ala     50 55 60 Pro Ile Leu Pro Asn Arg Arg Gly Ala Pro Gln Trp Pro Pro Gly Val 65 70 75 80 Val Gly Ser Met Thr His Cys Thr Gly Tyr Arg Ala Ala Ala Val Ser                 85 90 95 Ser Val Ala Glu Ser Ala Ala Val Ser Ile Asp Ala Glu Pro Asp Ala             100 105 110 Pro Leu Pro Ala Gly Val Leu Glu Thr Val Thr Leu Pro Ser Glu Arg         115 120 125 Ala Leu Leu Ala Gly Leu Gly Arg Arg Arg Pro Asp Ile Ala Trp Asp     130 135 140 Arg Met Tyr Phe Ser Ala Lys Glu Ser Val Phe Lys Ala Trp Tyr Pro 145 150 155 160 Leu Thr Gly Arg Glu Leu Asp Phe Asp Glu Ala Glu Ile Ala Phe Asp                 165 170 175 Ala Ala Ala Gly Thr Phe Ser Ala Arg Leu Leu Val Pro Gly Pro Val             180 185 190 Val Gly Gly Arg Ser Val Pro Val Phe Pro Gly Arg Trp His Ala Asp         195 200 205 Arg Gly Leu Leu Val Thr Ala Val His Leu Pro Pro Pro Ala Ala     210 215 220 <210> 3 <211> 592 <212> PRT <213> Pseudonocardia autotrophica <400> 3 Met Gly Leu Leu Arg Pro His Arg Gly Pro Val Ala Leu Ala Val Leu 1 5 10 15 Thr Gly Val Ala Gly Ile Ala Leu Asn Ala Val Gly Pro Leu Leu Leu             20 25 30 Gly Arg Val Thr Asp Leu Ile Ala Val Gly Val Leu Gly Pro Gly Gly         35 40 45 Ala Gly Gly Pro Ala Ala Gly Ser Pro Gly Pro Ala Asp Gly Val Asp     50 55 60 Phe Asp Ser Val Ala Arg Leu Leu Leu Val Leu Leu Val Val Tyr Leu 65 70 75 80 Gly Ala Ser Leu Phe Thr Leu Val Gln Gly Arg Ile Val Ala Ser Val                 85 90 95 Val Trp Gln Val Ile His Asp Leu Arg Gly Arg Ala Arg Ala Lys Leu             100 105 110 Ser Arg Leu Pro Leu Arg His Tyr Asp Arg His Ala Ala Gly Glu Thr         115 120 125 Leu Gly Arg Thr Thr Thr Asp Val Asp Asn Leu Gln Gln Thr Leu Gln     130 135 140 Gln Thr Leu Ala Glu Leu Ile Thr Ser Leu Leu Ser Leu Val Ala Met 145 150 155 160 Leu Thr Leu Met Val Val Ile Ser Pro Ser Leu Ala Met Val Met Ile                 165 170 175 Leu Ser Val Pro Leu Ala Gly Leu Leu Ala Val Gly Leu Gly Arg His             180 185 190 Ala His Pro Gln Phe Thr Thr Gln Trp Glu Ala Asn Gly Ala Leu Asn         195 200 205 Ala His Val Glu Glu Val Cys Thr Gly His Ser Leu Ile Arg Gly His     210 215 220 His Arg Arg Asp Glu Ala Arg Arg Arg Phe Ala Glu Cys Asn Asp Ala 225 230 235 240 Val Tyr Arg Ala Gly Ala Ser Ala Gln Thr Ser Ser Gly Ala Met Glu                 245 250 255 Pro Val Met Met Phe Val Ala Asn Leu Gly Tyr Leu Val Val Ala Val             260 265 270 Leu Gly Ala Trp Lys Val Leu Ser Gly Ser Leu Thr Leu Gly Asp Val         275 280 285 Gln Ala Phe Ile Leu Tyr Ala Arg Gln Phe Ser Gln Pro Ile Val Glu     290 295 300 Ile Ala Ser Val Ala Gly Arg Leu Gln Ser Gly Val Val Ser Ala Lys 305 310 315 320 Arg Val Phe Thr Leu Leu Asp Ala Pro Glu Gln Ser Pro Glu Pro Ala                 325 330 335 Arg Pro Ala Val Pro Ala Ala Pro Ala Gly Arg Val Glu Phe Arg Arg             340 345 350 Val Ser Phe Arg Tyr Val Pro Asp Val Pro Leu Ile Glu Asp Leu Ser         355 360 365 Leu Thr Val Glu Pro Gly Ser Thr Val Ala Ile Val Gly Ser Thr Gly     370 375 380 Ala Gly Lys Thr Thr Leu Gly Asn Leu Leu Val Arg Phe Tyr Glu Ile 385 390 395 400 Glu Gly Gly Gln Ile Leu Leu Asp Gly Val Asp Thr Ala Thr Met Thr                 405 410 415 Arg Ala Asp Leu Arg Ser Arg Phe Gly Leu Val Leu Gln Asp Thr Trp             420 425 430 Leu Phe Gly Gly Thr Ile Ala Glu Asn Ile Ala Tyr Gly Ala Pro Gly         435 440 445 Ala Thr Ser Asp Glu Ile Glu Gln Ala Ala Arg Ala Thr Cys Val Asp     450 455 460 Thr Phe Val Ala Thr Leu Pro Asp Gly Tyr Asp Thr Val Leu Asp Glu 465 470 475 480 Asp Ser Gly Gly Ala Ser Ala Gly Gln Lys Gln Leu Ile Thr Val Ala                 485 490 495 Arg Ala Phe Leu Ala Asp Pro Ala Val Leu Val Leu Asp Glu Ala Thr             500 505 510 Ser Ser Val Asp Thr Arg Thr Glu Leu Ile Gln Arg Ala Met Ala         515 520 525 Thr Val Arg Thr Gly Arg Thr Ser Phe Val Ile Ala His Arg Leu Ser     530 535 540 Thr Ile Arg Asp Ala Asp Arg Ile Val Val Met Asp Ala Gly Arg Ile 545 550 555 560 Val Glu Gln Gly Thr His Asp Thr Leu Leu Arg Ala Gly Gly Ala Tyr                 565 570 575 Ala Arg Leu His Ala Ala Arg Thr Ser Asp Ala Asp Thr Leu Ala Pro             580 585 590 <210> 4 <211> 584 <212> PRT <213> Pseudonocardia autotrophica <400> 4 Met Leu Trp Arg Leu Ala Arg Thr Arg Leu Arg Gly Tyr Ala Gly Pro 1 5 10 15 Ala Gly Ala Leu Val Val Leu Gln Thr Ala Gln Ile Ala Gly Thr Leu             20 25 30 Leu Leu Pro Thr Leu Gly Ala Ala Leu Ile Asp Glu Gly Val Val Arg         35 40 45 Ala Asp Pro Gly Arg Ile Ala Glu Leu Gly Val Leu Met Ala Gly Thr     50 55 60 Ala Val Val Gln Ile Ala Ala Ala Leu Ala Ala Thr Ala Leu Gly Ala 65 70 75 80 Arg Thr Ser Thr Ala Val Gly Arg Asp Leu Arg Ala Ala Val Phe Asp                 85 90 95 Arg Ile Leu Asp Phe Ser Ala Arg Glu Ile Gly Arg Phe Gly Thr Ala             100 105 110 Ser Leu Leu Thr Arg Thr Val Asn Asp Val Gln Gln Val Gln Asn Leu         115 120 125 Ala Arg Ser Gly Phe Gly Val Val Val Ala Pro Leu Met Cys Ile     130 135 140 Gly Ser Ile Val Leu Ala Leu Ala Gln Asp Val Pro Leu Ala Leu Leu 145 150 155 160 Leu Val Val Leu Val Leu Val Val Gly Val Ala Phe Gly Leu Leu Leu                 165 170 175 Val Arg Met Gly Gly Leu Tyr Gly Arg Met Gln Leu Ala Leu Asp Asp             180 185 190 Leu Gly Arg Leu Leu Arg Glu Ser Ile Thr Gly Val Arg Val Val Arg         195 200 205 Ser Phe Val Arg Glu Asp His Glu Gln Val Arg Phe Thr Arg Ser Asn     210 215 220 Asp Ala Phe Leu Asp Leu Ser Arg Gln Val Gly Arg Leu Ile Ala Thr 225 230 235 240 Met Leu Pro Leu Val Leu Leu Met Met Asn Val Phe Thr Val Val Leu                 245 250 255 Met Trp Leu Gly Ala His Arg Ile Asp Ala Gly Val Met Gln Leu Gly             260 265 270 Ala Leu Ser Ala Phe Leu Phe Tyr Leu Ser Leu Ile Leu Met Ser Val         275 280 285 Val Met Leu Ala Phe Val Phe Leu Gln Val Pro Arg Ala Arg Val Gly     290 295 300 Ala Gly Arg Ile Leu Glu Val Leu Asp Thr Glu Pro Ala Val Ala Ala 305 310 315 320 Pro Ala Thr Pro Ala Pro Leu His Gly Pro Ala Gly Arg Val Glu Ile                 325 330 335 Arg Asp Ala Glu Phe Arg Tyr Pro Gly Ala Glu Arg Ala Val Leu Arg             340 345 350 Gly Val Asp Leu Val Val Glu Pro Gly Glu Arg Leu Ala Val Leu Gly         355 360 365 Gly Thr Gly Ser Gly Lys Ser Thr Leu Leu Asn Leu Val Leu Arg Leu     370 375 380 Val Asp Pro Thr Ala Gly Thr Val Arg Val Gly Gly Thr Asp Val Arg 385 390 395 400 Arg Leu Asp Pro Ala Val Leu Thr Gly Val Val Gly Phe Val Pro Gln                 405 410 415 Arg Pro Tyr Leu Phe Ala Gly Thr Val Ala Ser Asn Leu Arg Phe Gly             420 425 430 Arg Thr Asp Ala Thr Asp Asp Glu Leu Trp Glu Ala Leu Arg Val Ala         435 440 445 Gln Ala Asp Gly Phe Val Ala Arg Met Pro Gly Gly Leu Asp Ala Glu     450 455 460 Ile Ala Gln Gly Gly Thr Thr Val Ser Gly Gly Gln Arg Gln Arg Leu 465 470 475 480 Cys Ile Ala Arg Thr Leu Val Arg Arg Pro Glu Ile Tyr Leu Phe Asp                 485 490 495 Asp Cys Phe Ser Ala Leu Asp Gln Ala Thr Asp Ala Ala Leu Arg Ala             500 505 510 Ala Leu Ala Pro Trp Thr Ala Gly Ala Thr Val Ile Thr Val Thr Gln         515 520 525 Arg Val Ala Thr Ala Arg Asp Ala Asp Arg Val Val Val Leu Asp Ala     530 535 540 Gly Arg Leu Val Ala Asp Gly Thr His Asp Asp Val Leu Arg Asp Ser 545 550 555 560 Pro Thr Tyr Arg Glu Ile Ala Asn Ser Gln Pro Thr Glu Glu Asp Val                 565 570 575 Ala His Gly Leu Ala Gly Arg His             580 <210> 5 <211> 344 <212> PRT <213> Pseudonocardia autotrophica <400> 5 Met Ser Lys Arg Ala Leu Ile Thr Gly Ile Thr Gly Gln Asp Gly Ser 1 5 10 15 Tyr Leu Ala Glu His Leu Leu Ser Gln Gly Tyr Gln Val Trp Gly Leu             20 25 30 Ile Arg Gly Gln Ala Asn Pro Arg Lys Thr Arg Val Ser Arg Leu Ala         35 40 45 Ser Glu Leu Glu Phe Val Asp Gly Asp Leu Met Asp Gln Ala Ser Leu     50 55 60 Val Ser Ala Val Asp Thr Val Gln Pro Asp Glu Val Tyr Asn Leu Gly 65 70 75 80 Ala Ile Ser Phe Val Pro Met Ser Trp Gln Gln Ala Glu Leu Val Thr                 85 90 95 Glu Val Asn Gly Thr Gly Val Leu Arg Val Leu Glu Ala Ile Arg Met             100 105 110 Val Ser Gly Leu Ser Met Ser Arg Thr Ala Ser Pro Asn Gly Gln Ile         115 120 125 Arg Phe Tyr Gln Ala Ser Ser Ser Glu Met Phe Gly Lys Ala Ala Glu     130 135 140 Thr Pro Gln Arg Glu Thr Thr Leu Phe His Pro Arg Ser Pro Tyr Gly 145 150 155 160 Ala Ala Lys Ala Tyr Gly His Tyr Ile Thr Arg Asn Tyr Arg Glu Ser                 165 170 175 Phe Gly Met Tyr Ala Val Ser Gly Met Leu Phe Asn His Glu Ser Pro             180 185 190 Arg Arg Gly Gln Glu Phe Val Thr Arg Lys Ile Ser Leu Ala Val Ala         195 200 205 Arg Ile Lys Leu Gly Leu Gln Arg Asp Leu Ala Leu Gly Asn Leu Asp     210 215 220 Ala Val Arg Asp Trp Gly Tyr Ala Gly Asp Tyr Val Arg Ala Met His 225 230 235 240 Leu Met Leu Gln Gln Gly Glu Pro Asp Asp Tyr Val Ile Gly Thr Gly                 245 250 255 Gln Met His Ser Val Arg Asp Ala Val Gln Ile Ala Phe Glu His Val             260 265 270 Gly Leu Asp Trp Arg Asp Lys Val Val Ile Asp Pro Ala Leu Val Arg         275 280 285 Pro Ala Glu Val Glu Val Leu Cys Ala Asp Ser Leu Arg Ala Arg Arg     290 295 300 Leu Leu Asp Trp Thr Pro Glu Val Asp Phe Pro Glu Leu Met Arg Met 305 310 315 320 Met Val Asp Ser Asp Leu Glu His Val Ala Arg Glu Asn Glu Tyr Gly                 325 330 335 His Leu Leu Leu Ala Ala Asn Trp             340 <210> 6 <211> 9499 <212> PRT <213> Pseudonocardia autotrophica <400> 6 Met Asp Asn Glu Gln Lys Leu Arg Asp Tyr Leu Lys Leu Ala Thr Ala 1 5 10 15 Asp Leu Arg Arg Thr Arg Arg Arg Val Ser Glu Leu Glu Ser Ala Ala             20 25 30 Gln Glu Pro Ile Ala Val Val Gly Met Ala Cys Arg Tyr Pro Gly Gly         35 40 45 Val Arg Ser Pro Glu Asp Leu Trp Arg Met Val Glu Ala Gly Glu Asp     50 55 60 Gly Val Thr Pro Phe Pro Thr Asp Arg Gly Trp Asp Thr Ala Ala Phe 65 70 75 80 Ala Gly Ser Pro Thr Arg Ser Gly Gly Phe Leu His Asp Ala Pro Asp                 85 90 95 Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Val Ala Met             100 105 110 Asp Pro Gln Gln Arg Val Val Leu Glu Ser Ala Trp Glu Ala Phe Glu         115 120 125 Arg Ser Gly Ile Asp Pro Val Ser Leu Gln Gly Thr Arg Thr Gly Val     130 135 140 Phe Val Gly Ala Met Ala Gln Asp Tyr Arg Val Gly Pro Ala Asp Gly 145 150 155 160 Ala Glu Gly Phe Gln Leu Thr Gly Asn Thr Gly Ser Val Leu Ser Gly                 165 170 175 Arg Ile Ser Tyr Thr Phe Gly Thr Val Gly Pro Ala Val Thr Val Asp             180 185 190 Thr Ala Cys Ser Ser Ser Leu Val Ala Val His Leu Ala Thr Gln Ala         195 200 205 Leu Arg Gly Gly Glu Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val     210 215 220 Met Ser Gly Pro Gly Thr Phe Ile Glu Met Gly Arg Gln Gly Gly Leu 225 230 235 240 Ser Ala Asp Gly Arg Cys Arg Ser Phe Gly Asp Thr Ala Asp Gly Thr                 245 250 255 Gly Trp Ala Glu Gly Val Gly Leu Leu Val Leu Glu Arg Leu Ser Asp             260 265 270 Ala Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala         275 280 285 Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro     290 295 300 Ser Gln Gln Gln Val Ile Glu Gln Ala Leu Val Asn Ala Arg Leu Ser 305 310 315 320 Ala Gly Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu                 325 330 335 Gly Asp Pro Val Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Arg Asp             340 345 350 Arg Asp Val Glu Arg Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Ile         355 360 365 Ser His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val     370 375 380 Met Ala Met Arg His Gly Val Leu Pro Arg Thr Leu Leu Ala Glu Asp 385 390 395 400 Pro Ser Arg His Val Asp Trp Ser Pro Asp Thr Val Arg Ile Leu Thr                 405 410 415 Glu Asn Thr Asp Trp Pro Ala Thr Gly Ala Pro Arg Arg Ala Ala Val             420 425 430 Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Thr Ile Ile Glu Gln         435 440 445 Ala Pro Ala Pro Glu Thr Gly Thr Pro Ala Pro Glu Asp Asp Gly Pro     450 455 460 Ala Val Gly Glu Pro Gly Pro Thr Glu Pro Gly Thr Val Pro Val Leu 465 470 475 480 Leu Ser Gly Arg Thr Pro Glu Ala Leu Gln Ala Gln Ala Ala Ala Leu                 485 490 495 Gly Glu Ala Leu Ala Ala Ala Pro Asp Thr Pro Leu Thr Asp Val Ala             500 505 510 Trp Ser Leu Ala Thr Thr Arg Thr Ala Phe Ala His Arg Ala Val Leu         515 520 525 Leu Ala Ala Asp Arg Asp Ala Leu Ala Gly Gly Leu Asp Ala Leu Ala     530 535 540 Ala Gly Asp Pro Ala Ala Ala Gly Asp Thr Val Thr Ala Glu Ala Arg 545 550 555 560 Pro Asp Ser Arg Leu Ala Val Leu Phe Thr Gly Gln Gly Ser Gln Arg                 565 570 575 Ile Gly Ala Gly Arg Glu Leu Ala Ala Arg Phe Pro Val Phe Ala Glu             580 585 590 Ala Leu Asp Thr Val Leu Ser Ala Phe Asp Pro Glu Leu Gln Arg Pro         595 600 605 Leu Arg Glu Ile Leu Arg Arg Thr Thr Asp Gly Thr Thr Pro Asp Glu     610 615 620 Thr Ala Ala Ala Leu Leu Asp Asp Thr Ala Tyr Ala Gln Pro Ala Ile 625 630 635 640 Phe Ala Val Glu Val Ala Leu Tyr Arg Leu Val Thr Ser Leu Gly Val                 645 650 655 Thr Pro Gly His Leu Leu Gly His Ser Val Gly Glu Ile Ala Ala Ala             660 665 670 His Val Ala Gly Val Leu Ala Leu Asp Asp Ala Ala Thr Leu Val Ala         675 680 685 Ala Arg Gly Arg Leu Met Ala Ala Leu Pro Thr Gly Gly Ala Met Val     690 695 700 Ala Val Gln Ala Thr Glu Ala Glu Val Glu Ala Leu Leu Asp Gly Tyr 705 710 715 720 Arg Asp Arg Val Ser Val Ala Ala Val Asn Gly Pro Ser Ala Val Val                 725 730 735 Leu Ser Gly Ala Asp Glu Ala Val Thr Ala Val Ala Gly Leu Leu Ala             740 745 750 Asp Gln Gly Arg Arg Thr Arg Arg Leu Arg Val Ser His Ala Phe His         755 760 765 Ser Pro Leu Met Glu Pro Met Leu Asp Glu Phe Arg Ala Val Val Glu     770 775 780 Gly Leu Asp Leu Gln Ala Pro Leu Ile Pro Ile Val Ser Asp Val Thr 785 790 795 800 Gly Glu Leu Ala Thr Val Ala Gln Leu Thr Ser Ala Asp Tyr Trp Val                 805 810 815 Glu His Val Arg Ser Ala Val Arg Phe Ala Asp Gly Val Asp Trp Leu             820 825 830 Ala Arg His Asp Val Thr Ala Phe Leu Glu Leu Gly Pro Asp Gly Pro         835 840 845 Leu Ser Ala Met Thr Arg Asp Cys Leu Asp Ala Ala Asp Pro Gly Ala     850 855 860 Pro Ala Ser Val Ala Val Pro Ala Leu Arg Ala Gly Arg Pro Glu Glu 865 870 875 880 His Thr Leu Thr Ala Ala Leu Ala Ala Leu His Thr His Gly Thr Ala                 885 890 895 Val Asp Trp Ala Pro Trp Phe Ala Gly Thr Gly Ala Arg Arg Thr Asp             900 905 910 Leu Pro Thr Tyr Ala Phe Arg Arg Arg Arg Phe Trp Pro Lys Ala Leu         915 920 925 Gln Thr Gly Ala Ala Asp Leu Arg Ser Ala Gly Leu Gly Ala Ala Arg     930 935 940 His Pro Leu Leu Ser Ala Thr Val Ser Leu Ala Asp Ser Glu Gly Ala 945 950 955 960 Leu Leu Thr Gly Arg Leu Ser Leu Gln Thr His Pro Trp Leu Ala Asp                 965 970 975 His Thr Val Arg Gly Thr Thr Leu Leu Pro Gly Thr Ala Phe Leu Glu             980 985 990 Leu Ala Val Arg Ala Gly Asp Glu Val Gly Cys Asp Arg Val Glu Glu         995 1000 1005 Leu Thr Leu Ala Ala Pro Leu Ala Leu Pro Asp Glu Gly Gly Val     1010 1015 1020 Ala Val Gln Leu Trp Val Gly Ala Pro Asp Ala Gly Gly Arg Arg     1025 1030 1035 Thr Leu Thr Val Tyr Ala Arg Pro Asp Thr Asp Ala Asp Ala Glu     1040 1045 1050 His Asp Val Pro Trp Thr Pro His Ala Thr Gly Val Leu Ala Ala     1055 1060 1065 Gly Gly Ala Val Pro Ala Thr Pro Asp Ala Thr Glu Trp Pro Pro     1070 1075 1080 Ala Gly Ala Glu Pro Leu Gly Val Glu Asp Leu Tyr Asp Arg Leu     1085 1090 1095 Ala Gln Ala Gly Phe Gly Tyr Gly Pro Ala Phe Arg Gly Leu Thr     1100 1105 1110 Ala Ala Trp Arg His Asp His Ala Val Leu Ala Glu Ile Val Leu     1115 1120 1125 Pro Glu Ala Gly Arg Thr Asp Val Asp Ala Phe Gly Leu His Pro     1130 1135 1140 Ala Ala Leu Asp Ala Ala Leu His Ala Ala Gly Phe Val Glu Leu     1145 1150 1155 Gly Glu Arg Ser Arg Gly Gly Met Pro Phe Ser Trp Glu Gly Val     1160 1165 1170 Thr Leu His Ala Ser Gly Ala Gly Thr Leu Arg Val Arg Leu Thr     1175 1180 1185 Pro Val Ala Asp Asp Ala Ile Ala Val Ala Val Ala Asp Gly Thr     1190 1195 1200 Gly Ala Pro Val Val Thr Val Asp Ser Leu Val Leu Arg Gly Val     1205 1210 1215 Gly Glu Leu Asp Leu Asp Ser Ala Gly Ala Val Ala Arg Asp Ala     1220 1225 1230 Leu Phe Arg Leu Asp Trp Thr Pro Val Thr Pro Ala Gly Glu Val     1235 1240 1245 Pro Gly Ser Val Val Ile Ala Gly Asp Asp Val Leu Gly Leu Ala     1250 1255 1260 Thr His Pro Gly Leu Gly Ala Ala His Gly Gly Val Ala Gly Pro     1265 1270 1275 Thr Asp Leu Ala Thr Leu Val Thr Ala Asp Gly Pro Ala Pro Asp     1280 1285 1290 Val Val Leu Leu Gly Leu Ala Gly Gly Ala Glu Ala Ala Gln Ala     1295 1300 1305 His Arg Cys Ala Ala Asp Ala Leu Ala Ala Val Arg Thr Trp Leu     1310 1315 1320 Asp His Ala Asp Arg Leu Asp Gly Ser Arg Leu Val Val Val Thr     1325 1330 1335 Arg Gly Ala Thr Thr Gly Asp Asp Val Ala Ala Ala Ala Ala Trp     1340 1345 1350 Gly Leu Leu Arg Ser Ala Arg Ser Glu Asn Pro Gly Arg Phe Ala     1355 1360 1365 Leu Leu Asp Leu Ala Pro Asp Val Asp Pro Ala Asp Leu Pro Leu     1370 1375 1380 Thr Ala Leu Thr Ala Asp Glu Pro Glu Leu Leu Leu Thr Arg Asp     1385 1390 1395 Gly Leu Arg Ala Ala Arg Leu Val Arg Arg Pro Ala Pro Arg Glu     1400 1405 1410 Ala Gly Ala Thr Pro Ser Phe Gly Asp Gly Ala Val Leu Val Thr     1415 1420 1425 Gly Gly Thr Gly Gly Leu Gly Ala Val Val Ala Arg His Leu Ala     1430 1435 1440 Thr Thr His Gly Val Thr Asp Leu Leu Leu Val Gly Arg Arg Gly     1445 1450 1455 Pro Ala Ala Asp Gly Ala Ala Glu Leu Val Ser Asp Leu Thr Ala     1460 1465 1470 Ala Gly Ala Arg Ala Gln Val Val Ala Cys Asp Val Ser Asp Pro     1475 1480 1485 Ala Ala Val Thr Glu Leu Leu Gly Ala His Arg Val Thr Ser Val     1490 1495 1500 Val His Ala Ala Gly Val Leu Asp Asp Ala Thr Val Gly Ser Leu     1505 1510 1515 Thr Pro Gln Arg Leu Ala Ala Val Leu Arg Pro Lys Val Asp Ala     1520 1525 1530 Ala Trp Asn Leu His Thr Ala Ala Ala Ala Leu Gly Leu Asp Leu     1535 1540 1545 Asp Ala Phe Val Leu Phe Ser Ser Val Ala Gly Val Phe Gly Ser     1550 1555 1560 Pro Gly Gln Ala Asn Tyr Ala Ala Gly Asn Ala Ala Leu Asp Ala     1565 1570 1575 Leu Ala Ala His Arg Arg Ala Ala Gly Leu Ala Gly Leu Ser Leu     1580 1585 1590 Ala Trp Gly Pro Trp Glu Arg Thr Gly Gly Met Thr Gly Gly Val     1595 1600 1605 Ser Asp Glu Asp Met Ala Arg Met Ala Arg Ala Gly Thr Pro Ala     1610 1615 1620 Leu Thr Val Glu Gln Gly Leu Thr Leu Phe Asp Ala Ala Leu Gly     1625 1630 1635 Ala Pro Glu Pro Ala Leu Val Pro Val Arg Leu Asp Leu Pro Ala     1640 1645 1650 Leu Arg Ala Gly Gly Glu Val Pro Pro Leu Leu Arg Ser Leu Ile     1655 1660 1665 Arg Thr Arg Ala Arg Arg Thr Ala Ala Thr Gly Ser Ala Thr Ala     1670 1675 1680 Asn Gly Leu Ala Gln Arg Leu Ala Arg Leu Asp Ala Glu Gly Arg     1685 1690 1695 Glu Glu Met Val Leu Asp Leu Val Arg Gly Gln Val Ala Leu Val     1700 1705 1710 Leu Gly His Ala Gly Ala Ala Asp Val Asp Ala Gly Arg Ala Phe     1715 1720 1725 Arg Asp Leu Gly Phe Asp Ser Leu Thr Ala Val Glu Leu Arg Asn     1730 1735 1740 Arg Leu Gly Thr Val Thr Gly Leu Arg Leu Pro Ala Thr Leu Val     1745 1750 1755 Phe Asp His Pro Thr Val Arg His Leu Ala Ala His Val Thr Asp     1760 1765 1770 Glu Leu Leu Gly Ala Glu Thr Glu Ala Val Pro Ala Ala Arg Val     1775 1780 1785 Ala Val Asp Val Glu Asp Pro Ile Val Ile Val Gly Met Ala Cys     1790 1795 1800 Arg Tyr Pro Gly Gly Val Ser Thr Pro Asp Glu Leu Trp Arg Leu     1805 1810 1815 Val Thr Glu Gly Thr Asp Ala Ile Ser Gly Phe Pro Thr Asn Arg     1820 1825 1830 Asn Trp Asp Leu Glu Ala Leu His His Pro Asp Pro Asp His Pro     1835 1840 1845 Gly Thr Thr Tyr Thr Arg Ser Gly Gly Phe Leu His Glu Ala Gly     1850 1855 1860 Glu Phe Asp Pro Ala Phe Phe Gly Met Ser Pro Arg Glu Ala Leu     1865 1870 1875 Ala Thr Asp Ser Gln Gln Arg Gln Leu Leu Glu Thr Ser Trp Glu     1880 1885 1890 Ala Val Glu Arg Ala Gly Ile Asp Pro Ser Thr Leu Arg Gly Thr     1895 1900 1905 Ala Thr Gly Val Phe Ala Gly Val Met Tyr Ser Asp Tyr Asn Ala     1910 1915 1920 Val Leu Ala Gly Gly Pro Glu Phe Glu Gly Phe Gln Gly Val Gly     1925 1930 1935 Ser Ser Pro Ser Leu Ala Ser Gly Arg Val Ala Tyr Thr Leu Gly     1940 1945 1950 Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser     1955 1960 1965 Leu Val Ala Met His Trp Ala Met Gln Ala Leu Arg Thr Gly Glu     1970 1975 1980 Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val Met Ser Thr Pro     1985 1990 1995 Ala Ala Phe Val Asp Phe Ala Arg Gln Arg Gly Leu Ser Pro Asp     2000 2005 2010 Gly Arg Cys Lys Ala Phe Ser Asp Asp Ala Asp Gly Val Gly Trp     2015 2020 2025 Ser Glu Gly Val Gly Met Leu Val Leu Glu Arg Gln Ser Asp Ala     2030 2035 2040 Leu Arg His Gly His Asp Ile Leu Ala Val Val Arg Gly Ser Ala     2045 2050 2055 Val Asn Ser Asp Gly Ala Ser Asn Gly Ile Thr Ala Pro Asn Gly     2060 2065 2070 Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Ser Ala Gly     2075 2080 2085 Leu Ser Thr Asp Asp Val Asp Val Val Glu Ala His Gly Thr Gly     2090 2095 2100 Thr Ser Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr     2105 2110 2115 Tyr Gly Arg Asp Arg Asp Thr Asp Arg Pro Leu His Leu Gly Ser     2120 2125 2130 Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala     2135 2140 2145 Gly Val Ile Lys Met Val Leu Ala Met Arg His Gly Val Leu Pro     2150 2155 2160 Arg Thr Leu His Ala Asp Thr Arg Ser Ser His Val Asp Trp Thr     2165 2170 2175 Glu Gly Ala Val Glu Leu Leu Thr Glu Gln Thr Ala Trp Pro Glu     2180 2185 2190 Thr Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser     2195 2200 2205 Gly Thr Asn Val His Thr Val Leu Glu Gln Gly Pro Asp Ser Ala     2210 2215 2220 Pro Ala Pro Asp Pro Gly Pro Gly Ala Thr Pro Ala Val Val Pro     2225 2230 2235 Leu Leu Leu Ser Gly Arg Gly Arg Pro Ala Leu Arg Ala Gln Ala     2240 2245 2250 Gly Arg Leu Leu Asp His Leu Arg Asp His Pro Gly Val Arg Thr     2255 2260 2265 Ala Asp Leu Ala His Ser Leu Ala Thr Thr Arg Thr Arg Phe Asp     2270 2275 2280 Gln Arg Ala Ala Val Leu Ala Gly Asp Arg Glu Asp Leu Leu Ala     2285 2290 2295 Ala Leu Gly Ala Leu Ala Ala Gly Arg Pro Asp Pro Arg Val Val     2300 2305 2310 Glu Gly Glu Ala Ala Gly Arg Ala Arg Thr Ala Val Leu Phe Thr     2315 2320 2325 Gly Gln Gly Ser Gln Arg Ala Ala Met Gly Arg Glu Leu Tyr Ala     2330 2335 2340 Ala Gln Pro Val Phe Ala Ala Ala Phe Asp Glu Val Cys Ala Ala     2345 2350 2355 Leu Asp Pro Leu Leu Glu Arg Pro Leu Ala Glu Val Val Phe Ala     2360 2365 2370 Glu Gly Gly Thr Ala Glu Ala Ala Leu Leu Asp Glu Thr Gly Trp     2375 2380 2385 Thr Gln Pro Ala Leu Phe Ala Val Glu Val Ala Leu Tyr Arg Leu     2390 2395 2400 Val Glu Ser Trp Gly Val Arg Ala Asp Leu Val Ala Gly His Ser     2405 2410 2415 Ile Gly Glu Ile Thr Ala Ala Tyr Val Ala Gly Val Phe Thr Leu     2420 2425 2430 Ala Asp Ala Ala Arg Leu Val Ala Ala Arg Ala Arg Leu Met Gln     2435 2440 2445 Ala Leu Pro Thr Gly Gly Ala Met Val Ala Ile Ala Ala Gly Glu     2450 2455 2460 Asp Glu Val Thr Pro Leu Leu Asp Glu Arg Val Ser Ile Ala Ala     2465 2470 2475 Val Asn Ala Pro Gly Ser Val Val Val Ser Gly Asp Ala Asp Ala     2480 2485 2490 Thr Ala Ala Leu Ala Ala Thr Phe Ala Glu Gln Gly Arg Arg Thr     2495 2500 2505 Arg Thr Leu Arg Val Ser His Ala Phe His Ser Pro His Met Asp     2510 2515 2520 Gly Met Leu Glu Asp Phe Arg Ala Val Ala Glu Arg Ile Glu Tyr     2525 2530 2535 His Ala Pro Arg Ile Pro Val Val Ser Asn Leu Thr Gly Ala Arg     2540 2545 2550 Ala Ala Asp Thr Glu Leu Cys Glu Pro Gly Tyr Trp Val Arg His     2555 2560 2565 Val Arg Glu Ala Val Arg Phe Ala Asp Cys Val Thr Thr Leu His     2570 2575 2580 Asp Gln Gly Ala Thr Val Leu Leu Glu Leu Gly Pro Asp Ala Pro     2585 2590 2595 Leu Thr Ala Met Ala Arg Glu Thr Leu Gly Asp Gly Ala Asp Thr     2600 2605 2610 Ala Leu Val Pro Phe Leu Arg Ala Asp Arg Gly Glu Glu Leu Ala     2615 2620 2625 Ala Ala Thr Ala Ala Ala Arg Leu Gln Val His Gly Leu Asp Leu     2630 2635 2640 Asp Pro Ala Ala Leu Leu His Gly Thr Gly Ala Arg Arg Thr Ala     2645 2650 2655 Leu Pro Thr Tyr Ala Phe Gln His Glu Phe Tyr Trp Pro Gln Leu     2660 2665 2670 Pro Ala Ala Ala Ala Ser Ala Gly Glu Asp Thr Asp Pro Ala Asp     2675 2680 2685 Arg Gln Leu Trp Ala Ala Val Glu Arg Gly Asp Ala Ala Glu Leu     2690 2695 2700 Ala Gly Ile Leu Gly Leu Asp Ala Asp Asp Val Ala Thr Pro Leu     2705 2710 2715 Leu Pro Ala Leu Thr Thr Trp Arg Arg Gly Asn Arg Glu Lys Ala     2720 2725 2730 Arg Leu Asp Thr Leu Arg Tyr Arg Val Glu Trp Thr Arg Leu Arg     2735 2740 2745 Arg Pro Ala Ala Pro Val Leu Asp Gly Thr Trp Leu Leu Val Ala     2750 2755 2760 Thr Gly Ala Thr Thr Asp Ala Glu Thr Thr Leu Leu Asp Gly Leu     2765 2770 2775 Ala Asp Thr Leu Gly Ala His Gly Ala Arg Val Arg Arg Leu Val     2780 2785 2790 Leu Asp Asp Asp Cys Pro Ala Asp Arg Ala Ala Val Ala Ala Arg     2795 2800 2805 Leu Ala Ala Gly Thr Ala Asp Gly Asp Pro Ala His Val Leu Ser     2810 2815 2820 Leu Leu Pro Leu Asp Glu Arg Pro Ala Ala Gly Ala Ala Pro Leu     2825 2830 2835 Thr Arg Gly Leu Ala Leu Thr Val Ala Leu Val Gln Ala Leu Ala     2840 2845 2850 Asp Ala Asp Ala Gly Asp Ser Thr Gly Thr Thr Ala Arg Leu Trp     2855 2860 2865 Thr Ala Thr Arg Gly Ala Val Ser Thr Gly Pro Ala Asp Pro Val     2870 2875 2880 Thr His Pro Val Gln Ala Thr Ala Trp Gly Leu Gly Arg Ser Val     2885 2890 2895 Ala Leu Glu His Pro Arg Leu Trp Gly Gly Leu Val Asp Leu Pro     2900 2905 2910 Ala Glu Leu Asp Pro Arg Ser Ala Gln Arg Leu Ala Gly Val Leu     2915 2920 2925 Ala Asp Lys Asp Thr Pro Asp Gly Glu Asp Gln Val Ala Leu Arg     2930 2935 2940 Ala Ala Gly Val Ser Gly Arg Arg Leu Val Arg His Thr Val Asp     2945 2950 2955 Ala Leu Pro Pro Ala Thr Ala Phe Thr Ala Thr Gly Ser Val Leu     2960 2965 2970 Val Thr Gly Gly Thr Gly Gly Leu Gly Ala Glu Val Ala Arg Trp     2975 2980 2985 Leu Ala Arg Ser Gly Val Ala His Leu Val Leu Thr Ser Arg Arg     2990 2995 3000 Gly Pro Asp Ala Pro Gly Ala Ala Glu Leu Arg Asp Glu Leu Thr     3005 3010 3015 Ala Leu Gly Ala Ser Val Ala Ile Glu Ala Cys Asp Val Thr Asp     3020 3025 3030 Arg Asp Ala Leu Ala Ala Val Leu Asp Ala Val Pro Ala Asp Ala     3035 3040 3045 Pro Leu Thr Gly Val Val His Thr Ala Gly Val Gly His Tyr Asp     3050 3055 3060 Ala Leu Asp Thr Leu Asp Val Glu Gly Val Ala Ala Arg Thr Ala     3065 3070 3075 Ala Lys Ile Ala Gly Ala Ala His Leu Asp Asp Leu Leu Ala Asp     3080 3085 3090 Arg Glu Leu Asp Leu Phe Val Leu Phe Gly Ser Val Ala Gly Val     3095 3100 3105 Trp Gly Ser Gly Gly Gln Ser Ala Tyr Gly Ala Ala Asn Ala Tyr     3110 3115 3120 Leu Asp Ala Leu Ala Ala His Arg Arg Ala Arg Gly Ala Thr Ala     3125 3130 3135 Thr Ser Ile Ala Trp Gly Pro Trp Ala Gly Ser Gly Met Ala Thr     3140 3145 3150 Glu Glu Ser Val Ala Thr Thr Leu Gln Arg Gln Gly Leu Gly Leu     3155 3160 3165 Leu Asp Pro Gly Pro Ala Met Thr Glu Leu Arg Arg Ala Val Val     3170 3175 3180 Asp Ala Asp Thr Gln Val Thr Val Ala Asp Val Asp Trp Asp Arg     3185 3190 3195 Tyr Ala Pro Leu Phe Thr Ser Ala Arg Pro Ser Ala Leu Ile Ala     3200 3205 3210 Gly Leu Ala Asp Leu Ala Glu Pro Glu Ser Gly Val Ala Ala Thr     3215 3220 3225 Glu Ile Val Thr Arg Val Arg Ala Leu Asp Glu Pro Ala Gly Met     3230 3235 3240 Arg Leu Leu Thr Glu Leu Val Arg Gly Ala Ala Ala Ala Val Leu     3245 3250 3255 Gly His Gly Ser Ala Glu Ser Val Ala Gly Ser Arg Ala Phe Arg     3260 3265 3270 Asp Leu Gly Phe Asp Ser Leu Thr Gly Val Glu Leu Arg Ser Arg     3275 3280 3285 Leu Ala Ala Ala Thr Gly Leu Thr Leu Pro Ser Thr Leu Val Phe     3290 3295 3300 Asp His Pro Ser Pro Leu Glu Leu Ala Arg His Leu Arg Ala Glu     3305 3310 3315 Ile Leu Gly Thr Ala Ala Glu Gly Thr Gly Pro Val Ala Val Gly     3320 3325 3330 Ala Ala Asp Ala Glu Pro Ile Ala Ile Ile Gly Met Ala Cys Arg     3335 3340 3345 Phe Pro Gly Gly Val Ser Ser Pro Glu Ala Leu Trp Asp Leu Val     3350 3355 3360 Thr Ser Gly Thr Asp Ala Ile Ser Asp Phe Pro Val Asn Arg Gly     3365 3370 3375 Trp Asp Thr Ala Ala Leu Phe Asp Arg Asp Pro Asp Arg Pro Gly     3380 3385 3390 Thr Thr Tyr Ser Thr Gln Gly Gly Phe Leu His Thr Ala Asp Glu     3395 3400 3405 Phe Asp Pro Ser Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Val     3410 3415 3420 Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Thr Trp Glu Ser     3425 3430 3435 Phe Glu Arg Ala Gly Ile Arg Pro Asp Thr Val Arg Gly Ser Leu     3440 3445 3450 Thr Gly Thr Phe Ile Gly Ser Ser Tyr Gln Glu Tyr Gly Leu Gly     3455 3460 3465 Ala Gly Asp Gly Ala Glu Gly His Leu Val Thr Gly Thr Ser Pro     3470 3475 3480 Ser Val Leu Ser Gly Arg Leu Ser Tyr Val Phe Gly Leu Glu Gly     3485 3490 3495 Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala     3500 3505 3510 Leu His Leu Ala Cys Gln Ser Leu Arg Asn Gly Glu Ser Thr Leu     3515 3520 3525 Gly Val Ala Gly Gly Ala Thr Val Met Thr Thr Pro Asn Pro Phe     3530 3535 3540 Ile Ala Phe Ser Arg Gln Arg Ala Leu Ala Arg Asp Gly Arg Cys     3545 3550 3555 Lys Ala Phe Ser Asp Asp Ala Asp Gly Met Thr Leu Ala Glu Gly     3560 3565 3570 Val Gly Ile Val Leu Val Glu Arg Leu Ser Asp Ala Glu Arg His     3575 3580 3585 Gly His Pro Val Leu Ala Val Ile Arg Gly Ser Ala Ile Asn Gln     3590 3595 3600 Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln     3605 3610 3615 Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly Leu Glu Pro     3620 3625 3630 Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Pro Leu     3635 3640 3645 Gly Asp Pro Ile Glu Ala Gln Ala Leu Gln Thr Thr Tyr Gly Arg     3650 3655 3660 Asp Arg Asp Ala Ala Arg Ala Leu Leu Leu Gly Ser Val Lys Ser     3665 3670 3675 Asn Ile Gly His Thr Gln Ser Ala Ala Gly Val Ala Ser Val Ile     3680 3685 3690 Lys Thr Val Met Ala Leu Arg His Gly Val Leu Pro Arg Thr Leu     3695 3700 3705 His Ala Asp Glu Pro Ser Ser His Val Asp Trp Ser Ala Gly Ser     3710 3715 3720 Val Glu Leu Leu Ala Glu Gln Thr Ala Trp Pro Glu Thr Gly Arg     3725 3730 3735 Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn     3740 3745 3750 Ala His Thr Val Leu Glu Gln Ala Pro Glu Ala Ala Pro Val Ala     3755 3760 3765 Pro Ala Thr Pro Ser Gly Pro Val Leu Pro Ser Ala Pro Glu Pro     3770 3775 3780 Val Leu Pro Trp Val Leu Gly Ala Arg Gly Ala Ala Ala Leu Arg     3785 3790 3795 Gly Gln Ala Asp Arg Leu Leu Ala His Leu Glu Thr Thr Asp Ala     3800 3805 3810 Arg Pro Ala Asp Ile Gly Phe Ser Leu Val Ser Ala Arg Met Pro     3815 3820 3825 Phe Glu His Arg Ala Val Val Val Ala Thr Asp Pro Ala Asp Arg     3830 3835 3840 Ala Ala Gly Leu Arg Ala Val Ala Ala Asp Gly Pro Ser Gly Val     3845 3850 3855 Val Ala Arg Gly Val Ala Asp Val Glu Gly Arg Thr Val Phe Val     3860 3865 3870 Phe Pro Gly Gln Gly Ser Gln Trp Leu Gly Met Gly Ala Arg Leu     3875 3880 3885 Leu Glu Glu Ser Pro Val Phe Ala Asp Arg Val Ala Glu Cys Ala     3890 3895 3900 Glu Ala Leu Ala Glu Phe Thr Asp Trp Ser Leu Asp Asp Val Leu     3905 3910 3915 Arg Gly Ala Glu Gly Ala Pro Pro Val Glu Arg Val Asp Val Val     3920 3925 3930 Gln Pro Ala Thr Phe Ala Val Met Val Gly Leu Ala Ala Leu Trp     3935 3940 3945 Arg Ala His Gly Val Glu Pro Asp Ala Val Val Gly His Ser Gln     3950 3955 3960 Gly Glu Ile Ala Ala Ala Val Val Ser Gly Ala Leu Ser Leu Arg     3965 3970 3975 Asp Gly Ala Arg Val Val Ala Leu Arg Ser Arg Ala Ile Ala Arg     3980 3985 3990 Ser Leu Ala Gly Arg Gly Gly Met Met Ser Val Ala Leu Pro Val     3995 4000 4005 Ala Asp Ala Glu Gly His Leu Ala Gly Tyr Glu Gly Arg Val Ser     4010 4015 4020 Val Ala Ala Val Asn Gly Pro Arg Ser Ala Val Leu Ala Gly Glu     4025 4030 4035 Pro Asp Ala Leu Asp Glu Leu Leu Ala Ala Phe Asp Ala Ala Asp     4040 4045 4050 Val Arg Ala Arg Arg Ile Ala Val Asp Tyr Ala Ser His Ser His     4055 4060 4065 Gln Val Glu Asp Leu Arg Asp Glu Leu Ala Thr Thr Leu Ala Gly     4070 4075 4080 Leu Ala Pro Gln Pro Ser Gln Val Pro Val Phe Ser Thr Val Thr     4085 4090 4095 Gly Asp Trp Leu Asp Thr Thr Thr Met Asp Ala Ser Tyr Trp Tyr     4100 4105 4110 Glu Asn Leu Arg Asn Arg Val Arg Phe Ala Asp Ala Val Glu Ala     4115 4120 4125 Leu Gln Ala Ala Glu Tyr Arg Thr Phe Val Glu Thr Ser Pro His     4130 4135 4140 Pro Val Leu Ser Met Ser Val Gln Asp Val Leu Asp Asp Ala Gly     4145 4150 4155 Val Ala Gly Val Ala Gly Gly Thr Leu Arg Arg Asp Gln Gly Gly     4160 4165 4170 Tyr Asp Arg Phe Val Leu Ser Ala Ala Glu Leu Tyr Val Arg Gly     4175 4180 4185 Ala Ala Val Asp Trp Thr Arg Val Phe Asp Gly Thr Gly Ala Ser     4190 4195 4200 Arg Thr Asp Leu Pro Thr Tyr Ala Phe Ala His Asp Gln Leu Trp     4205 4210 4215 Val Leu Pro Pro Ala Val Thr Ala Ala Ala Asp Pro Gln Asp Glu     4220 4225 4230 Ala Phe Trp Ala Ala Val Glu Asp Gly Asp Val Ala Ala Leu Thr     4235 4240 4245 Ser Thr Leu Asp Thr Asp Pro Asp Ala Val Ala Ala Val Leu Pro     4250 4255 4260 Ala Leu Val Ser Trp Arg Arg Gly Arg Arg Asp Arg Ser Thr Leu     4265 4270 4275 Asp Ser Trp Arg Tyr Arg Val Ser Trp Lys Pro Ala Gly Ser Leu     4280 4285 4290 Pro Gln Arg Ser Leu Ala Gly Thr Trp Leu Val Val Ser Ala Glu     4295 4300 4305 Gly Thr Asp Asp Thr Glu Val Ala Gly Ala Leu Ala Ala His Gly     4310 4315 4320 Ala Asp Val Arg Arg Val Val Leu Asp Glu Thr Cys Thr Asp Arg     4325 4330 4335 Ala Val Leu Ala Gly Arg Leu Ala Ala Ala Thr Gly Asp Asp Ser     4340 4345 4350 Ala Ala Asp Pro Ala Ala Val Ser Gly Ile Val Ser Val Leu Ala     4355 4360 4365 Glu Ala Asp Thr Thr Thr Thr Val Pro Arg Thr Gly Leu Val Thr Gly     4370 4375 4380 Val Ala Leu Thr Val Ala Leu Ile Gln Ala Leu Gly Asp Ser Gly     4385 4390 4395 Ile Asp Ala Pro Met Trp Ala Leu Ser Arg Gly Ala Val Ala Thr     4400 4405 4410 Gly Arg Ala Asp Glu Val Ile Ala Pro Val Gln Ala Gln Val Leu     4415 4420 4425 Gly Ile Gly Trp Thr Ala Ala Leu Glu His Pro Gln Arg Trp Gly     4430 4435 4440 Gly Thr Ile Asp Leu Pro Val Ala Leu Asp Glu Arg Gly Ala Ala     4445 4450 4455 Arg Leu Val Ala Val Leu Ala Gly Glu Leu Gly Ala Glu Asp Gln     4460 4465 4470 Leu Ala Leu Arg Pro Thr Gly Val Phe Thr Arg Arg Ile Val Arg     4475 4480 4485 Ala Glu Pro Ala Gly Ala Arg Pro Ala Arg Thr Trp Asp Pro Arg     4490 4495 4500 Gly Thr Thr Leu Val Thr Gly Gly Ser Gly Thr Leu Ala Pro His     4505 4510 4515 Leu Ala Arg Arg Leu Ala Glu Arg Gly Ala Glu His Val Val Leu     4520 4525 4530 Leu Ser Arg Arg Gly Pro Asp Ala Pro Gly Ala Ala Glu Leu Leu     4535 4540 4545 Ala Glu Phe Asp Gly Ser Asp Thr Thr Val Glu Ala Val Ala Cys     4550 4555 4560 Asp Ile Thr Asp Arg Ala Ala Val Ala Gly Leu Leu Glu Arg Leu     4565 4570 4575 Asp Ala His Gly Ala Thr Val Arg Thr Val Leu His Thr Ala Ala     4580 4585 4590 Thr Ile Glu Leu Ala Thr Leu Asp Ala Thr Thr Gln Glu Glu Leu     4595 4600 4605 Ala Arg Val Leu His Ala Lys Val Thr Gly Ala Gln Val Leu Thr     4610 4615 4620 Glu Leu Leu Asp Glu Arg Gly Gly Asp Pro Ala Glu Val Val Leu     4625 4630 4635 Phe Ser Ser Thr Ala Gly Met Trp Gly Ser Gly Ala His Ala Ala     4640 4645 4650 Tyr Val Ala Gly Asn Ala His Leu Ala Ala Leu Ala Glu His Arg     4655 4660 4665 Arg Ala Arg Gly Leu Pro Thr Thr Ser Ile Ala Trp Gly Ile Trp     4670 4675 4680 Ala Asp Asp Leu Lys Leu Gly Arg Val Asp Pro Ala Ala Ile Arg     4685 4690 4695 Gly Ser Gly Leu Val Phe Met Asp Pro Gln Leu Ala Leu Asn Gly     4700 4705 4710 Leu Glu Arg Ala Leu Asp Asp Ala Glu Thr Val Val Ala Val Ala     4715 4720 4725 Asp Val Asp Trp Asp Thr Tyr His Pro Val Tyr Thr Ser Gly Arg     4730 4735 4740 Pro Thr Arg Leu Tyr Asp Glu Ile Pro Glu Val Val Ala Leu Thr     4745 4750 4755 Ala Ala Ala Glu Arg Thr Ala Gly Thr Val Ala Ala Gly Glu Phe     4760 4765 4770 Ala Ala Thr Leu Asp Gly Leu Thr Asp Ala Glu Ala Leu Arg Arg     4775 4780 4785 Val Leu Asp Val Val Arg Ala Glu Ala Ala Gly Val Leu Gly Met     4790 4795 4800 Ala Ser Ala Asp Asp Leu Thr Asp Gln Arg Ala Phe Arg Asp Val     4805 4810 4815 Gly Phe Asp Ser Leu Thr Ala Val Ala Leu Arg Asn Arg Leu Ala     4820 4825 4830 Ser Val Thr Gly Leu Thr Leu Pro Ser Thr Met Val Phe Asp His     4835 4840 4845 Pro Thr Pro Ala Ala Leu Ala Glu Phe Leu Arg Ala Glu Leu Ala     4850 4855 4860 Gly Ala Thr Pro Val Ala Ala Gly Ala Gly Ser Thr Ala Ala Ala     4865 4870 4875 Gln Asp Gln Asp Asp Pro Ile Val Val Val Gly Met Ser Cys Arg     4880 4885 4890 Tyr Pro Gly Gly Val Ala Ser Ala Glu Asp Leu Trp Arg Val Ala     4895 4900 4905 Leu Asp Glu Val Asp Ala Ile Ser Gly Phe Pro Asp Asp Arg Gly     4910 4915 4920 Trp Asp Ala Ala Ser Leu Tyr Asp Pro Asp Pro Asp Arg Ala Gly     4925 4930 4935 His Thr Tyr Ser Thr Gln Gly Gly Phe Leu Arg Asp Val Ala Asp     4940 4945 4950 Phe Asp Pro Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ser     4955 4960 4965 Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Thr Trp Glu Thr     4970 4975 4980 Phe Glu His Ala Gly Ile Asp Pro Thr Ala Gln Arg Gly Ser Arg     4985 4990 4995 Thr Gly Thr Phe Ile Gly Ala Ser Tyr Gln Asp Tyr Ala Ser Gly     5000 5005 5010 Ala Pro Ala Ala Glu Gly Ala Glu Gly His Met Ile Thr Gly Thr     5015 5020 5025 Leu Pro Ser Val Leu Ser Gly Arg Val Asn Tyr Leu Phe Gly Phe     5030 5035 5040 Glu Gly Pro Ala Val Thr Leu Asp Thr Ala Cys Ser Ser Ser Leu     5045 5050 5055 Val Ala Met His Leu Ala Cys Gln Ser Leu Arg Thr Gly Glu Ser     5060 5065 5070 Thr Leu Ala Leu Ala Gly Gly Val Ser Ile Met Ser Thr Pro Met     5075 5080 5085 Ser Phe Val Gly Phe Ser Arg Gln Arg Ala Leu Ala Glu Asp Gly     5090 5095 5100 Arg Cys Lys Ala Tyr Ala Asp Gly Ala Asp Gly Met Thr Leu Ala     5105 5110 5115 Glu Gly Val Gly Leu Val Leu Leu Glu Arg Leu Ser Asp Ala Val     5120 5125 5130 Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Val     5135 5140 5145 Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro     5150 5155 5160 Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Gly Ala Gly Val     5165 5170 5175 Ala Pro Glu Glu Ile Asp Val Leu Glu Gly His Gly Thr Gly Thr     5180 5185 5190 Ala Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Phe Ala Thr Tyr     5195 5200 5205 Gly Arg Asp Arg Asp Thr Asp Arg Pro Leu Leu Leu Gly Ser Val     5210 5215 5220 Lys Ser Asn Ile Gly His Thr Gln Met Ala Ser Gly Val Ala Ser     5225 5230 5235 Val Ile Lys Leu Val Arg Ala Leu Gln Glu Gly Val Val Pro Ser     5240 5245 5250 Ser Leu His Ile Asp Gln Pro Ser Thr His Val Asp Trp Ser Ser     5255 5260 5265 Gly Ala Ile Asp Leu Leu Thr Glu Arg Thr Ala Trp Pro Glu Thr     5270 5275 5280 Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly     5285 5290 5295 Thr Asn Val His Thr Ile Leu Glu Gln Ala Pro Ala Val Pro Ala     5300 5305 5310 Ala Ala Pro Ala Val Pro Leu Pro Asp Asp Val Val Ala Pro Val     5315 5320 5325 Leu Val Ser Gly Arg Gly Glu Thr Ala Leu Arg Asp Gln Ala Gly     5330 5335 5340 Arg Leu Leu Asp Leu Leu Asp Glu Arg Pro Gln Leu Arg Pro Ala     5345 5350 5355 Glu Leu Ala His Ala Leu Gly Thr Thr Arg Ala Ala Leu Glu Gln     5360 5365 5370 Arg Gly Ala Val Val Ala Gly Asp Arg Asp Glu Leu Val Arg Gly     5375 5380 5385 Leu Thr Ala Leu Arg Asp Gly Gly Thr Ala Pro Gly Thr Val Arg     5390 5395 5400 Gly Thr Ala Gly Arg Gly Arg Thr Ala Phe Leu Phe Thr Gly Gln     5405 5410 5415 Gly Ser Gln Arg Ala Gly Ala Gly Ala Glu Leu Tyr Ala Arg Tyr     5420 5425 5430 Pro Val Phe Ala Asp Ala Leu Asp Asp Val Ala Ala Arg Leu Asp     5435 5440 5445 Thr Asp Ala Gly Gly Pro Pro Leu Arg Glu Val Leu Phe Ala Glu     5450 5455 5460 Pro Gly Ser Asp Glu Ala Ala Leu Leu Glu Arg Thr Gly His Ala     5465 5470 5475 Gln Pro Ala Leu Phe Ala Leu Glu Val Ala Leu Phe Arg Leu Leu     5480 5485 5490 Glu Ser Trp Gly Val Val Pro Asp Leu Leu Ala Gly His Ser Val     5495 5500 5505 Gly Glu Ile Ala Ala Ala His Val Ala Gly Val Leu Ser Leu Asp     5510 5515 5520 Asp Ala Cys Thr Leu Val Ala Ala Arg Gly Arg Leu Met Glu Ala     5525 5530 5535 Leu Pro Ala Gly Gly Ala Met Val Ala Val Glu Ala Ala Glu Asp     5540 5545 5550 Glu Val Ala Pro Leu Leu Thr Asp Gly Val Gly Ile Ala Ala Val     5555 5560 5565 Asn Gly Pro Ala Ala Val Val Val Ser Gly Asp Val Asp Glu Val     5570 5575 5580 Asp Ala Val Ala Ala Arg Leu Ala Ala Gln Gly Arg Arg Thr His     5585 5590 5595 Arg Leu Arg Val Ser His Ala Phe His Ser Pro Leu Met Glu Pro     5600 5605 5610 Met Leu Asp Glu Phe Arg Ala Val Val Ser Gly Leu Asp Tyr Ala     5615 5620 5625 Ala Pro Ala Ile Pro Ile Val Ser Thr Val Thr Gly Thr Leu Ala     5630 5635 5640 Thr Ala Asp Arg Leu Thr Asp Pro Gly Tyr Trp Val Glu His Val     5645 5650 5655 Arg Ala Thr Val Arg Phe Ala Asp Gly Val Ala Thr Leu Ala Gly     5660 5665 5670 Gln His Asp Val Arg Thr Phe Val Glu Leu Gly Pro Asp Gly Val     5675 5680 5685 Leu Ser Ala Ala Ala Arg Asp Thr Val Gly Asp Glu Pro Gly Thr     5690 5695 5700 Ala Leu Leu Ala Leu Leu Arg Lys Asp Arg Pro Glu Val Arg Thr     5705 5710 5715 Val Leu Ala Ala Val Ala Gly Ala His Cys His Gly Ala Arg Leu     5720 5725 5730 Asp Arg Arg Ala Leu Leu Ala Gly Tyr Gly His Gly Arg Val Ala     5735 5740 5745 Leu Pro Ser Tyr Ala Phe Gln Arg Glu Arg Tyr Trp Pro Glu Thr     5750 5755 5760 Ala Ala Ala Ala Val Pro Glu Gly Thr Gly Ala Asp Ala Glu Phe     5765 5770 5775 Trp Ala Ala Val Glu Arg Asp Asp Val Glu Gly Leu Val Gly Ser     5780 5785 5790 Leu Gly Leu Asp Asp Ala Thr Val Ser Ala Met Val Pro Ala Leu     5795 5800 5805 Thr Ala Trp Arg Arg Arg Arg Gly Glu Gln Ala Thr Arg Asp Gly     5810 5815 5820 Trp Arg Tyr Arg Ile Thr Trp Ala Pro Arg Gly Gly Ser Pro Ala     5825 5830 5835 Gly Gly Asp Leu Asp Gly Arg Arg Leg Val Leu Val Pro Gln Thr     5840 5845 5850 Tyr Arg Asp Asp Ala Thr Ala Ala Trp Ala Ala Asp Val Glu Ala     5855 5860 5865 Ala Leu Gly Gly Gly Gly Leu Glu Arg Val Thr Val Thr Gly Thr     5870 5875 5880 Asp Arg Ala Thr Leu Ala Ala Ala Val Thr Ala Ala Ala Gly Glu     5885 5890 5895 Gly Pro Glu Phe Ala Gly Val Leu Ser Leu Leu Pro Phe Ala Asp     5900 5905 5910 Gly Asp Ala Gly His Pro Gly Val Pro Ala Ala Leu Ser Leu Thr     5915 5920 5925 Thr Thr Ala Val Gln Ala Leu Gly Asp Ala Gly Val Asp Ala Pro     5930 5935 5940 Leu Trp Thr Val Thr Arg Gly Ala Val Ala Val Gly Arg Ser Glu     5945 5950 5955 Glu Val Thr Glu Leu Asp Gln Ala Ala Val Trp Gly Leu Leu Arg     5960 5965 5970 Thr Ala Ala Leu Glu Leu Pro Gly Arg Ile Gly G Val Thr Asp     5975 5980 5985 Leu Pro Ala Val Val Asp Ala Pro Ala Ala Arg Arg Leu Arg Gly     5990 5995 6000 Val Leu Ala Ala Thr Asp Gly Glu Asp Ala Val Ala Val Arg Ala     6005 6010 6015 Ser Gly Val Phe Leu Arg Arg Leu Val His Ala Pro Ala Arg Ala     6020 6025 6030 Gly Ala Thr Pro Ala Pro Phe Asp Ala Thr Thr Gly Thr Val Leu     6035 6040 6045 Ile Thr Gly Gly Thr Gly Gly Ile Gly Gly His Val Ala Arg Arg     6050 6055 6060 Leu Ala Arg Glu Gly Ala Ala His Leu Leu Leu Ala Ala Arg Arg     6065 6070 6075 Gly Pro Asp Ala Pro Gly Ala Ala Ala Leu Arg Ala Glu Leu Glu     6080 6085 6090 Glu Leu Gly Ala Arg Val Thr Val Ala Ala Cys Asp Val Ala Asp     6095 6100 6105 Arg Glu Ala Leu Ala Ala Leu Leu Asp Thr Val Pro Ala Glu Leu     6110 6115 6120 Pro Leu Val Gly Val Phe His Thr Ala Gly Val Leu Glu Asp Arg     6125 6130 6135 Val Leu Asp Ala Leu Thr Pro Gln Ser Tyr Ser Gly Val Leu Arg     6140 6145 6150 Ala Lys Thr Val Ala Ala Gln His Leu Asp Glu Leu Thr Arg Asp     6155 6160 6165 Ser Asp Leu Ala Ala Phe Val Leu Phe Ser Ser Thr Ala Gly Met     6170 6175 6180 Ile Gly Ala Ala Gly Gln Gly Asn Tyr Ala Ala Ala Asn Ala Tyr     6185 6190 6195 Leu Asp Ala Leu Ala Glu His Arg Arg Ala Arg Gly Leu Pro Ala     6200 6205 6210 Leu Ser Val Ala Trp Gly Pro Trp Asp Gly Ser Gly Met Val Ala     6215 6220 6225 Asp Ala Ala Glu Val Ala Ala Arg Val Arg Arg Gly Gly Phe Ala     6230 6235 6240 Pro Leu Asp Pro Glu Thr Ala Ala Val Ala Leu Leu Arg Ala Val     6245 6250 6255 Asp Gly Ser Arg Glu Gly Gly Glu Thr Thr Leu Ala Ile Ala Asp     6260 6265 6270 Met Asp Trp Glu Arg Phe Leu Arg Ala Phe Gly Ser Val Arg Pro     6275 6280 6285 Met Pro Leu Val Ala Asp Leu Pro Glu Val Ala Arg Leu Ala Ala     6290 6295 6300 Pro Thr Thr Gly Gly Asp Thr Gly Thr Gly Leu Arg Gly Arg Leu     6305 6310 6315 Ala Ala Leu Pro Asp Asp Glu Arg Leu Gly Val Val Leu Asp Val     6320 6325 6330 Leu Arg Thr Gln Val Ala Ala Val Leu Gly His Ala Asp Pro Arg     6335 6340 6345 Thr Val Asp Asp Asp Arg Ala Phe Arg Asp Leu Gly Phe Asp Ser     6350 6355 6360 Leu Thr Ile Leu Glu Leu Arg Asn Ala Leu Asn Ala Ala Thr Gly     6365 6370 6375 Leu Ser Leu Pro Ala Thr Leu Val Tyr Asp Arg Pro Thr Pro Arg     6380 6385 6390 Glu Met Ala Gly Phe Leu Leu Gly Glu Leu Leu Gly Thr Leu Pro     6395 6400 6405 Glu Gln Arg Gly Pro Val Arg Thr Ser Ala Ala Val Asp Asp Pro     6410 6415 6420 Ile Val Val Val Gly Met Ala Cys Arg Phe Pro Gly Gly Val Arg     6425 6430 6435 Thr Pro Glu Asp Leu Trp Glu Leu Val Ala Arg Gly Asp Asp Gly     6440 6445 6450 Ile Thr Gly Phe Pro Asp Asp Arg Gly Trp Asp Leu Ala Ala Leu     6455 6460 6465 Gly Asp Gly Ala Ser Ala Thr Leu Arg Gly Gly Phe Leu Asp Gly     6470 6475 6480 Val Ala Asp Phe Asp Ala Arg Phe Phe Gly Ile Ser Pro Arg Glu     6485 6490 6495 Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Thr     6500 6505 6510 Trp Glu Ala Val Glu Arg Ala Gly Ile Asp Pro Ala Thr Leu Arg     6515 6520 6525 Gly Ser Ala Thr Gly Val Phe Val Gly Thr Asn Gly Gln Asp Tyr     6530 6535 6540 Ala Thr Leu Leu Arg Arg Ser Ala Asp Asp Val Ser Gly Tyr Ala     6545 6550 6555 Ala Thr Gly Asn Thr Ala Ser Val Met Ser Gly Arg Leu Ser Tyr     6560 6565 6570 Thr Leu Gly Leu Glu Gly Pro Ala Val Thr Ile Asp Thr Ala Cys     6575 6580 6585 Ser Ser Ser Leu Val Ala Leu His Trp Ala Gly Arg Ala Leu Thr     6590 6595 6600 Asp Gly Glu Ala Asp Leu Val Leu Ala Gly Gly Val Ser Val Met     6605 6610 6615 Ser Gly Pro Asp Ser Phe Val Glu Phe Ser Thr Gln Gly Gly Leu     6620 6625 6630 Ala Pro Asp Gly His Cys Lys Pro Phe Ser Asp Asp Ala Asp Gly     6635 6640 6645 Thr Ala Trp Ser Glu Gly Val Gly Met Leu Val Leu Glu Arg Leu     6650 6655 6660 Ser Asp Ala Arg Arg His Gly His Arg Val His Gly Val Ile Gly     6665 6670 6675 Gly Ser Ala Ile Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala     6680 6685 6690 Pro Ser Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala     6695 6700 6705 Asp Ala Gly Leu Thr Pro Ala Asp Val Asp Thr Val Glu Ala His     6710 6715 6720 Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu     6725 6730 6735 Ile Ala Thr Tyr Gly Arg Asp Arg Asp Thr Asp Arg Pro Leu His     6740 6745 6750 Leu Gly Thr Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala     6755 6760 6765 Gly Val Ala Gly Val Ile Lys Met Leu Leu Ala Met Arg His Ala     6770 6775 6780 Thr Leu Pro Arg Thr Leu His Ala Gly Thr Pro Ser Ser His Val     6785 6790 6795 Asp Trp Ser Ala Gly Thr Val Ala Leu Leu Asp Glu Ala Arg Asp     6800 6805 6810 Trp Pro Glu Thr Gly Gly Thr Arg Arg Ala Gly Val Ser Ala Phe     6815 6820 6825 Gly Val Ser Gly Thr Asn Ala His Val Ile Val Glu Gln Ala Pro     6830 6835 6840 Pro Ala Pro Glu Thr Ala Ala Ala Glu Leu Pro Gly Glu Val Pro     6845 6850 6855 Trp Val Leu Ser Ala Arg Thr Pro Ala Ala Leu Gln Glu Gln Val     6860 6865 6870 Asp Arg Val Val Gly Ala Ala Gly Gly His Thr Ala Thr Asp Val     6875 6880 6885 Ala Ala Thr Leu Ala Gly Gly Arg Thr Leu Phe Gly His Arg Ala     6890 6895 6900 Val Leu Leu Ala Gly Pro Asp Gly Ile Arg Glu Ala Ala Arg Gly     6905 6910 6915 Thr Ala Pro Arg Thr Pro Gly Arg Thr Ala Phe Leu Phe Ser Gly     6920 6925 6930 Gln Gly Ala Gln His Ala Gly Met Gly Arg Ala Leu His Glu Arg     6935 6940 6945 His Pro Ala Tyr Ala Glu Ala Leu Asp Glu Val Leu Ala Arg Phe     6950 6955 6960 Asp Thr Leu Leu Asp Ala Pro Leu Arg Asp Ala Leu Phe Ala Glu     6965 6970 6975 Pro Gly Ser Ala Ala Ala Asp Arg Leu Asp Glu Thr Gly Thr Thr     6980 6985 6990 Gln Pro Ala Leu Phe Ala Val Glu Val Ala Leu Tyr Arg Leu Leu     6995 7000 7005 Glu Ser Trp Gly Arg Thr Pro Asp Leu Val Ala Gly His Ser Val     7010 7015 7020 Gly Glu Ile Ala Ala Ala His Val Ala Gly Val Leu Ser Leu Asp     7025 7030 7035 Asp Ala Cys Ala Leu Val Ala Ala Arg Ala Ser Leu Met Gln Ala     7040 7045 7050 Leu Pro Ala Gly Gly Ala Met Val Ala Val Glu Ala Thr Glu Asp     7055 7060 7065 Glu Val Thr Pro Leu Leu Thr Asp Gly Val Ala Ile Ala Ala Val     7070 7075 7080 Asn Gly Pro Ala Ser Leu Val Leu Ser Gly Asp Ala Asp Gly Val     7085 7090 7095 Gly Ala Leu Ala Asp Arg Leu Ala Ala Asp Gly Arg Arg Thr Arg     7100 7105 7110 Arg Leu Arg Val Ser His Ala Phe His Ser Pro Leu Met Asp Ala     7115 7120 7125 Met Leu Asp Gly Phe Ala Ala Ala Ile Ser Gly Ile Thr Phe Ala     7130 7135 7140 Ala Pro Arg Ile Pro Leu Val Ser Thr Leu Thr Gly Ala Leu Ala     7145 7150 7155 Gly Pro Glu Leu Gly Glu Pro Gly Tyr Trp Val Arg His Val Arg     7160 7165 7170 Glu Ala Val Arg Phe Ala Asp Gly Val Arg Ala Leu His Glu Ala     7175 7180 7185 Gly Ala Thr Val Phe Ala Glu Ile Gly Pro Asp Ala Ala Leu Leu     7190 7195 7200 Ala Pro Ala Gln Gln Thr Leu Asp Thr Val Ala Pro Ala Asp Gly     7205 7210 7215 Pro Ala Ala Val Val Val Ala Leu Gln Arg Arg Asp Arg Asp Ala     7220 7225 7230 Gly Thr Ala Leu Leu Glu Gly Leu Ala Val Leu His Val His Gly     7235 7240 7245 Ala Gly Pro Asp Trp Ala Ala Val Leu Pro Ala Arg Gly Pro Val     7250 7255 7260 Glu Leu Pro Thr Tyr Pro Phe Gln Arg Glu Arg Tyr Trp Pro Glu     7265 7270 7275 Pro Gly Thr Pro Gly Gly Gly Ala Gly Pro Ala Asp Pro Ala Asp     7280 7285 7290 Ser Ala Phe Trp Ala Ala Val Glu Arg Glu Asp Leu Glu Ser Leu     7295 7300 7305 Ser Gly Ser Leu Gly Val Asp Gly Asp Thr Leu Ala Thr Met Val     7310 7315 7320 Pro Ala Leu Ser Ala Trp Arg Arg Arg His Gly Ala Glu Ser Ala     7325 7330 7335 Ala Ala Thr Trp Arg Tyr Arg Glu Thr Trp Thr Pro Val Pro Thr     7340 7345 7350 Pro Ala Ala Ala Val Thr Gly Arg Thr Leu Val Leu Val Ser Ala     7355 7360 7365 Gly Ala Asp Ala Trp Thr Asp Ala Leu Val Thr Ala Leu Asp Ala     7370 7375 7380 Glu Thr Val Val Val Gly Asp Gly Ser Thr Asp Glu Leu Thr Val     7385 7390 7395 Ala Leu Gly Val Leu Asp Asp Ala Asp Arg Pro Val Asp Arg Val     7400 7405 7410 Val Ser Leu Leu Ala Ala Gly Thr Ser Gly Leu Pro Ser Gly Pro     7415 7420 7425 Ala Arg Ala Ser Ala Leu Leu Ala Ala Leu Ala Ala Ala Gly Ile     7430 7435 7440 Asp Ala Pro Leu Trp Cys Val Thr Arg Gly Ala Val Ala Ala Glu     7445 7450 7455 Gly Thr Thr Pro Ala Pro Gly Gln Ala Ala Leu Trp Gly Met Gly     7460 7465 7470 Arg Val Ala Ala Leu Glu Thr Pro Gln Arg Phe Gly Gly Leu Ala     7475 7480 7485 Asp Leu Pro Ala Gly Pro Asp Ala Val Ala Ala Ala Ala Ala Thr     7490 7495 7500 Ala Leu Ala Ala Leu Leu Thr Glu Pro Gly Gly Glu Ser Glu Ile     7505 7510 7515 Ala Val Arg Ala Thr Gly Ala Tyr Ala Arg Arg Leu Val Arg Ala     7520 7525 7530 Gly Gly Ala Glu Gly Thr Ala Ala Ala Arg Trp Arg Pro His Gly     7535 7540 7545 Thr Val Leu Val Val Gly Gly Thr Gly Ala Leu Gly Arg Arg Ala     7550 7555 7560 Ala Arg Arg Leu Ala Ala Asp Gly Ala Thr His Leu Val Leu Thr     7565 7570 7575 Ala Pro Ser Ala Ala Ala Ser Val Asp Thr Asp Ala Val Thr Ala     7580 7585 7590 Glu Leu Ala Asp Leu Gly Val Ala Val Thr Val Ser Asp Ala Asp     7595 7600 7605 Pro Ala Asp Pro Ala Ala Leu Ala Ala Leu Leu Asp Gly Ala Pro     7610 7615 7620 Asp Ala Pro Thr Ala Val Val His Ala Gly Glu Ala Leu Gly Asp     7625 7630 7635 Ala Gly Leu Ala Asp Val Leu Ala Pro Val Glu Ala Leu Ala Thr     7640 7645 7650 Ala Leu Thr Gly Pro Ala Thr Ala His Asp Leu Asp Ala Val Val     7655 7660 7665 Leu Phe Gly Ser Ile Ala Gly Val Trp Gly Val Arg Gly Arg Ala     7670 7675 7680 Val Glu Ala Ala Ala Gly Ala His Leu Asp Ala Val Ala Arg Ser     7685 7690 7695 Leu Arg Gly Arg Gly Val Pro Ala Thr Ala Val Ala Trp Gly Ala     7700 7705 7710 Trp Thr Asp Leu Ala Asp Arg Ser Thr Ala Ala His Leu Arg Met     7715 7720 7725 Asn Gly Leu Pro Ala Met Asp Gly Asp Ala Ala Met Ala Ala Leu     7730 7735 7740 Gly Arg Ala Val Ala Asp Gly Ser Val Ala Glu Thr Val Ala Asp     7745 7750 7755 Val Arg Trp Glu Thr Phe Ala Pro Ala His His Asp Ala Arg Ala     7760 7765 7770 Thr Thr Leu Phe Asp Ala Leu Pro Glu Ala Arg Thr Ala Leu Ser     7775 7780 7785 Gly Ala Ala Arg Glu Arg Ala Gly Arg Glu Ala Ala Ala Ser Gly     7790 7795 7800 Tyr Gly Gln Trp Leu Ala Glu Gln Pro Glu Ala Glu Arg Asp Thr     7805 7810 7815 Ile Leu Leu Asp Leu Val Ala Ala Thr Ala Thr Thr Val Leu Gly     7820 7825 7830 Leu Thr Asp Gly Glu Pro Leu Glu Pro Asp Leu Pro Phe Arg Asp     7835 7840 7845 Leu Gly Phe Asp Ser Leu Thr Ala Val Asp Leu Arg Asn Gln Leu     7850 7855 7860 Thr Ala Ala Thr Gly Val Ala Leu Pro Ala Thr Leu Val Phe Asp     7865 7870 7875 His Pro Asn Pro Ala Ala Leu Ala Ala His Leu Arg Gly Glu Leu     7880 7885 7890 Leu Gly Gly Gly Asp Gly Ala Ala Glu Pro Val Thr Leu Ala Ala     7895 7900 7905 Ser Ala Thr Gly Asp Asp Pro Ile Val Ile Val Gly Met Ala Cys     7910 7915 7920 Arg Tyr Pro Gly Gly Val Ala Ser Pro Glu Asp Leu Trp Gln Leu     7925 7930 7935 Met Ala Asp Asp Val Asp Ala Val Gly Ala Phe Pro Asp Asp Arg     7940 7945 7950 Gly Trp Asp Leu Glu Thr Leu Ala Gly Asp Gly Pro Gly Arg Ser     7955 7960 7965 Ala Thr Ala Gln Gly Gly Phe Leu His Asp Ala Thr Asp Phe Asp     7970 7975 7980 Pro Gly Pro Phe Gly Val Ser Pro Arg Glu Ala Leu Val Met Asp     7985 7990 7995 Pro Gln Gln Arg Ile Leu Leu Glu Thr Ser Trp Glu Ala Leu Glu     8000 8005 8010 Arg Thr Gly Ile Asp Pro Ser Ser Leu Arg Gly Ser Ala Glu Tyr     8015 8020 8025 Gly Val Phe Val Gly Gly Gly Ser Gly Asp Tyr Arg Pro Pro Ala     8030 8035 8040 Glu Ala Gly Gln Trp Gln Thr Ala Gln Ser Ala Ser Leu Leu Ser     8045 8050 8055 Gly Arg Val Ala Tyr Thr Phe Gly Val Gln Gly Pro Thr Val Ser     8060 8065 8070 Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala     8075 8080 8085 Ala Gln Ala Leu Arg Ala Gly Glu Cys Ser Ile Ala Leu Ala Gly     8090 8095 8100 Gly Val Thr Val Met Ala Thr Pro Val Gly Phe Val Glu Phe Ser     8105 8110 8115 Ala Gln Gly Ala Leu Ser Pro Asp Gly Arg Cys Arg Ala Phe Ser     8120 8125 8130 Asp Asp Ala Asn Gly Thr Gly Trp Ser Glu Gly Val Gly Met Leu     8135 8140 8145 Val Val Glu Arg Leu Ser Asp Ala Arg Arg Arg Gly His Arg Val     8150 8155 8160 His Ala Val Leu Arg Gly Ser Ala Ile Asn Gln Asp Gly Ala Ser     8165 8170 8175 Asn Gly Leu Thr Ala Pro Ser Gly Pro Ala Gln Gln Arg Val Ile     8180 8185 8190 Arg Gln Ala Leu Ala Asn Ala Arg Leu Thr Pro Gly Glu Val Asp     8195 8200 8205 Ala Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile     8210 8215 8220 Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Gln Asp Arg Asp Arg     8225 8230 8235 Pro Val Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln     8240 8245 8250 Ala Ala Ser Gly Val Gly Gly Val Ile Lys Met Val Leu Ala Met     8255 8260 8265 Glu His Gly Val Leu Pro Arg Ser Leu Tyr Ala Glu Asn Pro Ser     8270 8275 8280 Ser His Val Asp Trp Thr Ala Gly Asp Ala Gln Leu Leu Thr Ala     8285 8290 8295 Pro Thr Gly Trp Pro Glu Thr Gly Arg Pro Arg Arg Ala Ala Val     8300 8305 8310 Ser Ser Phe Gly Ala Ser Gly Thr Asn Ala His Ala Ile Leu Glu     8315 8320 8325 Gln Pro Pro His Ala Asp Val Val Arg Arg Ala Asp Asp Thr Pro     8330 8335 8340 Asp Asp Pro Gly Ala Val Ala Val Leu Leu Ser Gly Arg Thr Glu     8345 8350 8355 Ala Ala Leu Arg Ala Gln Ala Asp Glu Leu Val Ala His Leu Gly     8360 8365 8370 Glu His Pro Asp Leu Arg Leu Arg Asp Leu Ala Arg Ala Leu Ala     8375 8380 8385 Thr Ser Arg Ala Thr Phe Asp His Arg Ala Ala Val Thr Ala Thr     8390 8395 8400 Cys Arg Asp Glu Leu Leu Ala Gly Leu Thr Ala Val Ala His Gly     8405 8410 8415 Asp Thr Ala Pro Gln Val Ala Thr His Arg Leu Glu Arg Ser Gly     8420 8425 8430 Arg Ser Ala Ala Leu Phe Ser Gly Gln Gly Ala Gln Arg Leu Gly     8435 8440 8445 Met Gly Arg Glu Leu Tyr Glu Arg His Pro Val Phe Ala Asp Ala     8450 8455 8460 Val Asp Ala Val Leu Ala Arg Leu Asp Gly His Leu Asp Arg Pro     8465 8470 8475 Leu Arg Asp Thr Met Trp Gly Thr Asp Ala Asp Ala Leu Ala Glu     8480 8485 8490 Thr Gly Ala Thr Gln Pro Ala Leu Phe Ala Val Glu Val Ala Leu     8495 8500 8505 Tyr Arg Leu Val Glu Ser Trp Gly Val Arg Pro Asp Phe Val Ala     8510 8515 8520 Gly His Ser Ile Gly Glu Ile Ser Ala Ala His Val Ala Gly Val     8525 8530 8535 Leu Asp Leu Asp Asp Ala Cys Arg Leu Val Ala Ala Arg Ala Arg     8540 8545 8550 Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val Ala Val Glu     8555 8560 8565 Ala Asp Glu Asp Glu Val Thr Pro Leu Leu Thr Asp Gly Val Ala     8570 8575 8580 Ile Ala Gly Val Asn Gly Pro Gly Ser Val Val Leu Ser Gly Asp     8585 8590 8595 Asp Asp Ala Val Thr Ala Leu Ala Ala Val Leu Ala Gly Glu Gly     8600 8605 8610 Arg Arg Thr Ser Arg Leu Gln Val Ser His Ala Phe His Ser Ala     8615 8620 8625 Arg Met Asp Pro Met Leu Ala Glu Phe Arg Thr Val Ala Glu Glu     8630 8635 8640 Leu Asp Tyr His Glu Pro Arg Ile Pro Val Val Ser Asn Leu Thr     8645 8650 8655 Gly Ala Val Ala Ala Ala His Glu Leu Cys Ser Ala Glu Tyr Trp     8660 8665 8670 Val Arg His Val Arg Gly Thr Val Arg Phe Ala Asp Gly Val Arg     8675 8680 8685 Ala Leu Ala Ala Arg Gly Val Ser Thr Phe Leu Glu Leu Gly Pro     8690 8695 8700 Asp Ala Val Leu Ser Ala Leu Val Pro Arg Ser Ala Pro Asp Ala     8705 8710 8715 Leu Ala Val Pro Ala Leu Arg Arg Asp Arg Asp Glu Glu Ala Thr     8720 8725 8730 Leu Val Ala Ala Leu Ala Arg Leu His Thr His Gly Ala Gly Pro     8735 8740 8745 Arg Trp Glu Ala Phe Phe Ala Gly His Asp Thr Arg Arg Val Asp     8750 8755 8760 Leu Pro Thr Tyr Pro Phe Gln Arg Asp Arg Phe Trp Pro Asp Val     8765 8770 8775 Met Pro Gly Gln Glu Thr Arg Ala Val Ala Pro Ala Gly Pro Gly     8780 8785 8790 Thr Pro Asp Glu Ile Asp Ala Ala Phe Trp Glu Ala Val Ala Gln     8795 8800 8805 Glu Asp Phe Ser Ala Leu Glu Thr Gln Leu Asp Val Glu Gly Ala     8810 8815 8820 Ala Leu Ser Ala Val Leu Pro Ala Leu Met Asp Trp Arg Ser Arg     8825 8830 8835 Arg Ala Gln Glu Ala Arg Leu Ala Arg Trp Arg His Arg Ile Val     8840 8845 8850 Trp Lys Arg Leu Thr Gly Ser Ala Thr Gly Arg Arg Arg Thr Pro     8855 8860 8865 Glu Gly Thr Trp Leu Ala Val Leu Pro Glu Gly Thr Ala Val Asp     8870 8875 8880 Pro Trp Val Thr Thr Val Leu Asp Gly Ile Gly Thr Ala Val Val     8885 8890 8895 Thr Val Glu Thr Gly Ser Thr Asp Arg Ala Val Val Ala Ala Ala     8900 8905 8910 Leu Thr Ala Gln Leu Pro Ala Gly Thr Pro Val Ala Gly Val Val     8915 8920 8925 Ser Leu Leu Ala Leu Arg Asp Glu Leu Thr Gly Asp Val Pro Asp     8930 8935 8940 Gly Val Gly Leu Thr Thr Gly Leu Leu Gln Ala Leu Gly Asp Ala     8945 8950 8955 Gly Val Asp Ala Pro Leu Trp Cys Leu Thr Arg Gly Ala Val Ser     8960 8965 8970 Thr Gly Thr Thr Asp Arg Pro Ala Arg Pro Leu Gln Ala Ala Ile     8975 8980 8985 Trp Gly Leu Gly Arg Val Ala Ala Leu Glu Tyr Pro Gln Arg Trp     8990 8995 9000 Gly Gly Leu Ala Asp Leu Pro Glu Asp Pro Asp Pro Arg Ala Ala     9005 9010 9015 Ala Ala Leu Gly Ala Val Leu Ala Gly Leu Asp Asp Glu Asp Gln     9020 9025 9030 Val Ala Val Arg Gly Ala Ala Val Leu Ala Arg Arg Leu Val Pro     9035 9040 9045 Ala Pro Pro Arg Glu Asp Thr Thr Thr Ala Trp Thr Pro Thr Gly     9050 9055 9060 Thr Val Leu Ile Thr Gly Gly Thr Gly Ala Leu Gly Gly His Val     9065 9070 9075 Ala Arg Arg Leu Ala Ala Asp Gly Ala Gln His Leu Val Leu Leu     9080 9085 9090 Gly Arg Arg Gly Pro Asp Ala Pro Gly Val Asp Gly Leu Arg Ala     9095 9100 9105 Glu Leu Glu Ala Leu Gly Ala Gly Val Thr Val Ala Ala Cys Asp     9110 9115 9120 Ala Ala Asp Arg Gly Gln Leu Ser Ala Val Leu Ala Ala Ile Pro     9125 9130 9135 Ala Asp Arg Pro Leu Thr Gly Val Val His Ala Ala Gly Val Leu     9140 9145 9150 Asp Asp Gly Ile Leu Asp Arg Leu Thr Pro Glu Arg Tyr Arg Glu     9155 9160 9165 Val Phe Arg Ser Lys Val Thr Ala Ala Leu Leu Leu Asp Glu Leu     9170 9175 9180 Thr Arg Gly Leu Asp Leu Asp Ala Phe Val Leu Phe Ser Ser Ala     9185 9190 9195 Ser Ser Ala Val Gly Asn Pro Gly Gln Ala Asn Tyr Ala Ala Ala     9200 9205 9210 Asn Ala Val Leu Asp Ala Leu Ala Glu Gln Arg Arg Ala Arg Gly     9215 9220 9225 Asp Ala Ala Thr Ser Ile Ser Trp Gly Val Trp Gly Gly Gly Gly     9230 9235 9240 Met Ala Gly Ala Gly Ser Ala Asp Asp Ala Ala Arg Arg Thr Gly     9245 9250 9255 Ile Gly Ala Met Asp Pro Ala Leu Ala Val Glu Thr Met Leu Arg     9260 9265 9270 Leu Ile Ala Gly Thr Ala Pro Thr Ala Val Val Ala Glu Val Glu     9275 9280 9285 Leu Asp Arg Phe Ala Gly Ala Phe Gly Gly Thr Arg Pro Ser Pro     9290 9295 9300 Leu Leu Arg Glu Phe Pro Gly Tyr Ala Glu Leu Val Ala Gly Arg     9305 9310 9315 Ala Gly Thr Arg Pro Gly Ala Ala Glu Asp Asp Leu Ala Ala Thr     9320 9325 9330 Leu Val Ala Leu Pro Pro Ala Arg Arg Leu Asp Thr Val Val Asp     9335 9340 9345 Leu Val Arg Ser Arg Ala Ala Gln Val Leu Gly Tyr Pro Gly Ser     9350 9355 9360 Asp Asp Val Gly Ala Glu Arg Ser Phe Arg Asp Leu Gly Ile Asp     9365 9370 9375 Ser Leu Gly Ala Val Glu Leu Arg Asn Gln Leu Gly Ala Ala Thr     9380 9385 9390 Gly Leu Gly Leu Pro Ala Thr Leu Val Phe Asp His Pro Thr Pro     9395 9400 9405 Ala Ala Val Ala Arg Tyr Leu Leu Asp Glu Leu Ala Gly Asp Asp     9410 9415 9420 Thr Gly Ala Asp Gly Glu Glu Ala Gly Ile Arg Ala Ala Leu Ala     9425 9430 9435 Thr Val Pro Leu Glu Arg Leu Arg Glu Leu Gly Val Leu Glu Pro     9440 9445 9450 Leu Leu Arg Leu Val Gly Arg Gly Glu Glu Thr Ala Ala Asp Asp     9455 9460 9465 Asp Thr Gly Thr Gly Pro Gly Gly Ser Glu Val Asp Ala Met Ser     9470 9475 9480 Val Asp Asp Leu Val Arg Ala Ala Leu Asp Gly Arg Pro Asp Asp     9485 9490 9495 Leu      <210> 7 <211> 5425 <212> PRT <213> Pseudonocardia autotrophica <400> 7 Met Asn Glu Lys His Ala Ser Gly Thr Ala Gly Gly Asn Asp Val Val 1 5 10 15 Thr Ala Leu Arg Ala Ala Val Lys Glu Thr Asp Arg Leu Arg Arg Gln             20 25 30 Asn Arg Met Leu Gln Ser Ala Ala Thr Glu Pro Ile Ala Val Val Gly         35 40 45 Met Gly Cys Arg Phe Pro Gly Gly Val Asp Ser Pro Glu Ala Leu Trp     50 55 60 Asp Met Val Ala Ala Gly Thr Asp Val Ile Ser Gly Phe Pro Thr Asp 65 70 75 80 Arg Gly Trp Asp Leu Asp Ala Leu His Ala Gly Gly Thr Asp Ala Arg                 85 90 95 Asp Thr Glu Ile Ser Met Gln Gly Gly Phe Leu Asp Gly Val Ala Asp             100 105 110 Phe Asp Pro Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Val Thr Met         115 120 125 Asp Pro Gln Gln Arg Leu Leu Leu Thr Thr Ala Trp Glu Ala Ile Glu     130 135 140 Arg Ala Gly Ile Asp Ala Ala Gly Leu Arg Gly Ser Arg Thr Gly Ala 145 150 155 160 Phe Ile Gly Thr Asn Gly Gln Asp Tyr Ala Tyr Leu Val Val Arg Ser                 165 170 175 Leu Asp Asp Ala Thr Gly Asp Val Gly Thr Gly Ile Ala Ala Ser Ala             180 185 190 Val Ser Gly Arg Leu Ser Tyr Thr Leu Gly Leu Glu Gly Pro Ala Leu         195 200 205 Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala     210 215 220 Val Ala Ser Leu Arg Asn Gly Glu Ser Ser Leu Ala Leu Ala Gly Gly 225 230 235 240 Val Asn Val Met Ser Thr Pro Gly Ser Leu Val Glu Phe Ser Arg Gln                 245 250 255 Gly Gly Leu Ala Arg Asp Gly Arg Cys Lys Ala Phe Ala Glu Gly Ala             260 265 270 Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly Ile Leu Val Leu Glu Arg         275 280 285 Leu Ser Asp Ala Arg Arg Leu Gly His Pro Val Leu Ala Val Val Arg     290 295 300 Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Phe Thr Ala Pro 305 310 315 320 Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ala Asn Ala                 325 330 335 Glu Leu Ser Ala Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly             340 345 350 Thr Pro Leu Gly Asp Pro Ile Glu Ala Gln Ser Ile Leu Ala Thr Tyr         355 360 365 Gly Arg Asp Arg Glu Arg Pro Leu Ala Leu Gly Ser Val Lys Ser Asn     370 375 380 Met Gly His Thr Gln Ala Ala Ser Gly Val Ala Gly Val Met Lys Met 385 390 395 400 Ile Met Ala Met Gln His Gly Glu Leu Pro Arg Thr Leu His Val Asp                 405 410 415 Arg Pro Ser Thr His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Leu             420 425 430 Thr Gln Ala Arg Pro Trp Pro Ala Val Glu Arg Pro Arg Arg Ser Gly         435 440 445 Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Val Glu     450 455 460 Gln Ala Pro Ala Pro Ala Glu Pro Ala Ala Glu Pro Ala Ala Arg Leu 465 470 475 480 Pro Gln Ala Leu Ala Trp Thr Val Ser Ala Arg Thr Pro Ala Ala Leu                 485 490 495 Arg Asp Gln Ala Ala Ala Leu Leu Ala His Val Glu Arg Asp His Ala             500 505 510 Pro Thr Ala Leu Asp Thr Gly Tyr Ser Leu Ala Thr Thr Arg Ala Val         515 520 525 Gln Glu His Arg Leu Ala Val Val Thr Gly Pro Asp Gly Arg Ala Gly     530 535 540 Arg Ala Ala Leu Ala Gly Trp Leu Glu His Gly Ser Ala Pro Gly Val 545 550 555 560 Ala Leu Gly His Val Thr Gly Arg Pro Arg Leu Ala Ala Leu Phe Ser                 565 570 575 Gly Gln Gly Ala Gln Arg Leu Gly Met Gly Arg Glu Leu Tyr Glu Arg             580 585 590 His Pro Val Phe Ala Ala Ala Phe Asp Glu Val Leu Thr Leu Leu Gly         595 600 605 Asp Asp Leu Arg Asp Val Val Trp Gly Thr Asp Ala Ala Ala Leu Asp     610 615 620 Glu Thr Gly Ala Thr Gln Pro Ala Leu Phe Ala Val Glu Val Ala Leu 625 630 635 640 Tyr Arg Leu Val Glu Ser Trp Gly Val Thr Pro Asp Leu Val Ala Gly                 645 650 655 His Ser Ile Gly Glu Ile Ala Ala Ala His Val Ala Gly Val Phe Ser             660 665 670 Leu Asp Asp Ala Cys Arg Leu Val Thr Ala Arg Ala Ser Leu Met Gln         675 680 685 Ala Leu Pro Arg Gly Gly Ala Met Val Ala Val Glu Ala Thr Glu Asp     690 695 700 Glu Val Thr Pro Leu Leu Thr Asp Gly Val Ala Ile Ala Ala Val Asn 705 710 715 720 Gly Pro Ser Ser Val Val Val Ser Gly Glu Glu Asp Ala Thr Leu Ala                 725 730 735 Val Ala Ala Arg Leu Ala Glu Gln Gly Arg Arg Thr Ser Arg Leu Arg             740 745 750 Val Ser His Ala Phe His Ser Pro Leu Met Asp Pro Met Leu Ala Glu         755 760 765 Phe Ala Ala Val Ala Glu Gly Leu Ser Tyr Ala Glu Pro Arg Ile Pro     770 775 780 Leu Val Ser Thr Leu Thr Gly Ala Pro Ala Thr Val Glu Leu Cys Asp 785 790 795 800 Pro Gly Tyr Trp Val Arg His Val Arg Glu Ala Val Arg Phe Ala Asp                 805 810 815 Gly Val Gly Ala Leu Thr Asp Ala Gly Ala Arg Met Phe Leu Glu Ile             820 825 830 Gly Pro Ala Gly Val Leu Thr Ala Leu Ala Ala Arg Ser Ala Pro Glu         835 840 845 Ala Thr Ala Val Ala Leu Gln Arg Thr Asp Arg Gly Glu Glu Glu Ala     850 855 860 Thr Val Ala Ala Leu Gly Ala Leu His Val Ala Gly Thr Ala Val Asp 865 870 875 880 Trp Glu Ala Val His Ala Gly Thr Gly Ala Arg Arg Thr Asp Leu Pro                 885 890 895 Thr Tyr Ala Phe Gln Tyr Glu Arg Tyr Trp Pro Lys Ala Val Gln Arg             900 905 910 Ser Gly Asp Ala Ala Gly Leu Gly Leu Ala Pro Ala Asp His Pro Leu         915 920 925 Leu Gly Ala Ala Met Ser Val Ala Gly Ser Asp Glu Leu Leu Leu Thr     930 935 940 Gly Thr Leu Ser Leu Thr Thr His Pro Trp Leu Ala Asp His Val Val 945 950 955 960 Gly Gly Met Val Phe Phe Pro Gly Thr Gly Phe Leu Glu Leu Ala Val                 965 970 975 Arg Ala Ala Asp Gln Ala Gly Cys Asp Arg Val Glu Glu Leu Met Leu             980 985 990 Ala Ala Pro Leu Val Leu Pro Ala Thr Gly Ala Val Gln Met Gln Ile         995 1000 1005 Ala Val Gly Ala Ala Asp Pro Asp Gly Thr Arg Asp Val Ser Val     1010 1015 1020 Tyr Ala Arg Pro Ala Gln Asp Pro Asp Ala Asp Trp Thr Arg His     1025 1030 1035 Ala Thr Gly Arg Val Ala Pro Gly Glu Gln Val Ala Glu Phe Asp     1040 1045 1050 Ala Arg Thr Trp Pro Pro Ala Gly Ala Glu Pro Val Asp Ile Asp     1055 1060 1065 Gly Leu Tyr Asp Arg Tyr Ala Gly Asn Gly Leu Gln Tyr Gly Pro     1070 1075 1080 Val Phe Arg Gly Leu Gln Ala Val Trp Arg Arg Gly Asp Glu Val     1085 1090 1095 Leu Ala Glu Val Ala Leu Pro Pro Ala Gly Ala Glu Asp Ala Gly     1100 1105 1110 Asp Phe Gly Leu His Pro Ala Leu Phe Asp Ala Val Leu His Ser     1115 1120 1125 Thr Val Phe Ala Ser Ala Asp Gly Asp Asp Arg Ser Leu Leu Pro     1130 1135 1140 Phe Ala Trp Asn Gly Val Ser Leu His Ala Gly Gly Ala Thr Ala     1145 1150 1155 Leu Arg Val Arg Val Thr Ser Ala Gly Pro Asp Ala Val Arg Ile     1160 1165 1170 Ser Ala Ala Asp Pro Gln Gly Asn Pro Val Ile Ser Val Asp Ser     1175 1180 1185 Leu Thr Leu Arg Ala Ala Gly Pro Asp Ala Ala Gly Pro Asp Arg     1190 1195 1200 Arg Asp Pro Gly Ser Leu Phe Arg Met Gly Trp Val Pro Gln Thr     1205 1210 1215 Leu Thr Pro Arg His Thr Pro Ala Thr Trp Ala Val Leu Asp Gly     1220 1225 1230 Ala Gly Ala Gly Asp Val Ala Ala Ala Leu Thr Ala Glu Pro Ala     1235 1240 1245 Ala Val Ser Thr Val Arg Thr Val Thr Gly Leu Ala Asp Leu His     1250 1255 1260 Asp Ala Asp Pro Pro Asp Leu Val Ala Val Pro Leu Thr Ala Pro     1265 1270 1275 Gly Ser Val Asp Thr Gly Pro Ala Ala Ala His Thr Leu Thr Arg     1280 1285 1290 Glu Val Leu Ala Leu Leu Gln Gln Trp Leu Ala Asp Asp Arg Leu     1295 1300 1305 Ala Arg Thr Arg Leu Val Val Leu Thr Arg Gly Ala Val Ala Asp     1310 1315 1320 Gly Ser Gly Ser Pro Leu Asp Leu Ala Thr Ala Pro Val Trp Gly     1325 1330 1335 Leu Leu Arg Ser Ala Gln Ser Glu Asn Pro Gly Arg Leu Leu Val     1340 1345 1350 Ala Asp Leu Asp Asp Thr Pro Ala Ser Leu Ala Ala Val Ala Gln     1355 1360 1365 Leu Pro Ala Leu Phe Asp Ala Asp Glu Pro Gln Ala Ile Val Arg     1370 1375 1380 Asp Gly Ala Val Arg Val Gly Arg Leu Ala Thr Leu Leu Ser Gly     1385 1390 1395 Ala Ala Leu Val Pro Pro Ala Gly Thr Pro Trp Arg Leu Gly Cys     1400 1405 1410 Arg Ala Lys Gly Ser Leu Asp Gly Leu Glu Leu Ala Pro His Pro     1415 1420 1425 Asp Val Leu Ala Pro Leu Arg Gly His Glu Val Arg Val Gly Ile     1430 1435 1440 Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Leu Asn Ala Leu Gly     1445 1450 1455 Met Tyr Pro Gly Asp Ala Gly Leu Phe Gly Ser Glu Ala Ala Gly     1460 1465 1470 Val Val Thr Gly Val Gly Pro Glu Val Thr Thr Leu Ala Pro Gly     1475 1480 1485 Asp Arg Val Thr Gly Met Leu Phe Gly Gly Phe Gly Pro His Gly     1490 1495 1500 Val Thr Asp Glu Arg Leu Leu Thr Thr Val Pro Asp Gly Trp Asp     1505 1510 1515 Trp Glu Thr Ala Ala Ser Val Pro Leu Val Phe Leu Thr Ala Tyr     1520 1525 1530 His Ala Leu Val Asp Leu Ala Asp Leu Gln Pro Gly Glu Lys Val     1535 1540 1545 Leu Ile His Ala Gly Ala Gly Gly Val Gly Met Ala Ala Val Gln     1550 1555 1560 Ile Ala His His Leu Gly Ala Glu Val Tyr Ala Thr Ala Ser Glu     1565 1570 1575 Pro Lys Gln Asp Val Leu Arg Gly Leu Gly Val Ala Pro Asp His     1580 1585 1590 Ile Ala Ser Ser Arg Thr Leu Glu Phe Ala Gly Thr Phe Ala Gly     1595 1600 1605 Ala Gly Ile Asp Val Val Leu Asn Ala Leu Ser Gly Glu Phe Val     1610 1615 1620 Asp Ala Ser Met Gly Leu Leu Gly Asp Gly Gly Arg Phe Leu Glu     1625 1630 1635 Met Gly Lys Thr Asp Ile Arg Asp Pro Ala Asp Leu Pro Asp Ala     1640 1645 1650 Ile Thr Tyr Arg Phe Phe Asp Leu Gly Ala Val Asp Pro His Arg     1655 1660 1665 Ile Gln Gln Met Leu Val Ala Leu Ala Gly Leu Phe Ala Asp Gly     1670 1675 1680 Ala Leu Ser Pro Leu Pro Val Arg Ser Trp Asp Val Arg His Ala     1685 1690 1695 Val Glu Ala Phe Arg Phe Met Ser Ser Ala Arg His Val Gly Lys     1700 1705 1710 Leu Val Leu Thr Val Pro Pro Pro Leu Asp Pro Gln Gly Thr Val     1715 1720 1725 Leu Ile Thr Gly Gly Thr Gly Leu Ala Ala Ala Leu Ala Arg     1730 1735 1740 His Leu Val Ala Thr His Gly Val Ala His Leu Leu Leu Ala Gly     1745 1750 1755 Arg Arg Gly Pro Asp Ala Pro Gly Ala Thr Ala Leu Arg Glu Glu     1760 1765 1770 Leu Thr Ala Ala Gly Ala Gln Val Thr Val Ala Ala Cys Asp Val     1775 1780 1785 Ala Asp Arg Asp Ala Leu Ala Ala Leu Leu Asp Gly Val Asp Pro     1790 1795 1800 Ala His Pro Leu Thr Ala Val Val His Thr Ala Gly Val Leu Asp     1805 1810 1815 Asp Gly Thr Val Thr Ser Ser Leu Thr Pro Ala Ala Val Asp Ala Val     1820 1825 1830 Leu Ala Pro Lys Val Asp Ala Ala Trp His Leu His Asp Leu Thr     1835 1840 1845 Arg Asp His Glu Leu Ala Ala Phe Val Leu Tyr Ser Ser Thr Ala     1850 1855 1860 Gly Val Met Gly Gly Pro Gly Gln Gly Asn Tyr Ala Ala Gly Asn     1865 1870 1875 Thr Phe Leu Asp Ala Leu Ala Ala His Arg His Ala Leu Gly Leu     1880 1885 1890 Pro Ala Thr Ser Leu Ala Trp Gly Ala Trp Glu Gln Gly Ala Gly     1895 1900 1905 Met Thr Gly Gly Leu Ser Asp His Asp Val Ala Arg Val Gly Ser     1910 1915 1920 Gly Gly Met Pro Leu Leu Ser Val Glu Arg Gly Leu Ala Leu Tyr     1925 1930 1935 Asp Ala Ala Thr Leu Ala Ala Glu Pro Leu Val Val Pro Leu Gly     1940 1945 1950 Leu Thr Gly Gly Gly Thr Pro Pro Thr Ala Gly Gly Val Pro Ala     1955 1960 1965 Val Leu Arg Gly Leu Val Arg Ser Gly Gly Arg Arg Arg Ala Gly     1970 1975 1980 Thr Ala Gly Val Ala Arg Ala Gly Leu Ala Glu Arg Leu Ala Gly     1985 1990 1995 Leu Pro Ala Asp Gly Arg Gly Ala Phe Leu Val Glu Leu Val Arg     2000 2005 2010 Ala Glu Ala Ala Thr Val Leu Gly Leu Gly Ser Gly Asp Gly Val     2015 2020 2025 Asp Ala Arg His Glu Phe Arg Arg Ile Gly Phe Asp Ser Leu Thr     2030 2035 2040 Ala Ile Glu Leu Arg Asn Arg Leu Gly Ser Ala Ser Gly Leu Thr     2045 2050 2055 Leu Pro Ala Thr Leu Ile Phe Asp Tyr Pro Thr Pro Glu Arg Leu     2060 2065 2070 Ala Ala Tyr Leu Leu Glu Glu Leu Ala Gly Glu Asp Thr Gly Pro     2075 2080 2085 Val Gly Asp Gly Pro Val Val Ala Arg Ala Asp Ala Asp Asp Pro     2090 2095 2100 Val Val Val Val Gly Ile Gly Cys Arg Phe Pro Gly Gly Val Gly     2105 2110 2115 Ser Pro Glu Gln Leu Trp Asp Leu Val Ala Asn Gly Thr Asp Ala     2120 2125 2130 Ile Thr Gly Phe Pro Pro Asp Arg Glu Trp Asp Arg His Pro Pro     2135 2140 2145 Leu Gly Gly Gly Glu Pro Ala Asp Leu Thr Gly Gln Gly Gly Phe     2150 2155 2160 Leu Asp Asp Ile Ala Gly Phe Asp Ala Glu Phe Phe Gly Ile Ala     2165 2170 2175 Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Ile Leu Leu     2180 2185 2190 Glu Val Ala Trp Glu Ala Ala Glu Arg Ala Gly Ile Asp Pro His     2195 2200 2205 Thr Leu Arg Gly Ser Arg Thr Gly Val Phe Met Gly Val Ser Gly     2210 2215 2220 Gln Asp Tyr Ser Gly Leu Val Met Arg Ser Ala Asp Asp Ile Ala     2225 2230 2235 Ser His Ala Thr Thr Gly Leu Ala Val Ser Val Val Ser Gly Arg     2240 2245 2250 Leu Ala Tyr Val Leu Gly Leu Glu Gly Pro Ala Leu Ser Val Asp     2255 2260 2265 Thr Ala Cys Ser Ser Ser Leu Val Ser Leu His Leu Ala Ala Ala     2270 2275 2280 Ala Leu Arg Ser Gly Glu Cys Asp Met Ala Leu Ala Gly Gly Val     2285 2290 2295 Thr Val Met Thr Thr Pro Ala Asn Phe Thr Gly Phe Ser Arg Met     2300 2305 2310 Gly Gly Leu Ala Gly Asp Gly Arg Cys Lys Ala Phe Ser Asp Ser     2315 2320 2325 Ala Asp Gly Thr Gly Trp Ser Glu Gly Ala Ala Val Leu Thr Leu     2330 2335 2340 Glu Arg Leu Ser Ala Ala Arg Arg His Gly His Arg Val Leu Ala     2345 2350 2355 Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly     2360 2365 2370 Leu Thr Ala Pro Asn Gly Pro Ala Gln Gln Arg Val Ile Arg Gln     2375 2380 2385 Ala Leu Ala Asp Ala Gly Leu Glu Pro Gly Asp Val Asp Ala Val     2390 2395 2400 Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu Ala     2405 2410 2415 Gln Ala Val Leu Ala Thr Tyr Gly Arg Glu Arg Asp Pro Gln Arg     2420 2425 2430 Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln     2435 2440 2445 Ser Ala Ala Gly Ala Ala Gly Leu Ile Lys Met Ile Met Ser Met     2450 2455 2460 Ala His Gly Glu Leu Pro Arg Thr Leu His Val Thr Glu Pro Ser     2465 2470 2475 Ser His Val Asp Trp Ser Asp Gly Thr Val Ala Leu Val Thr Glu     2480 2485 2490 Arg Thr Pro Trp Pro Glu Thr Gly His Ala Arg Arg Val Gly Val     2495 2500 2505 Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Val Leu Glu     2510 2515 2520 Gln Pro Pro Ala Thr Gln Pro Ala Pro Pro Asp Ala Ala Thr Pro     2525 2530 2535 Asp Ala Ala Ala Pro Asp Ala Ala Gly Pro Asp Ala Ala Ala Pro     2540 2545 2550 Glu Val Val Ala Trp Pro Val Ser Ala Arg Thr Glu Ala Ala Leu     2555 2560 2565 Asp Ala Gln Leu Asp Arg Leu Arg Thr Ala Val Pro Gly Leu Thr     2570 2575 2580 Pro Thr Ala Val Ala Arg Thr Leu Ala Thr Gly Arg Ala Leu Phe     2585 2590 2595 Glu His Arg Ala Val Leu Leu Ala Gly Pro Gly Gly Thr Thr Glu     2600 2605 2610 Ala Ala Arg Gly Ala Ala Ala Thr Arg Gly Thr Ala Phe Leu Phe     2615 2620 2625 Ser Gly Gln Gly Ala Gln Arg Leu Gly Met Gly Arg Glu Leu His     2630 2635 2640 Ala Arg Phe Pro Val Phe Ala Asp Ala Phe Asp Glu Ala Val Ala     2645 2650 2655 Leu Leu Asp Ala Glu Leu Gly Gly Thr Leu Arg Asp Val Val Trp     2660 2665 2670 Gly Glu Asp Pro Glu Ala Leu Asp Arg Thr Arg His Thr Gln Pro     2675 2680 2685 Ala Leu Phe Ala Leu Glu Val Ala Leu Tyr Arg Leu Val Thr Ser     2690 2695 2700 Trp Gly Ile Arg Pro Gly Arg Leu Ala Gly His Ser Ile Gly Glu     2705 2710 2715 Ile Ala Ala Ala His Val Ala Gly Val Phe Ser Leu Ala Asp Ala     2720 2725 2730 Cys Arg Leu Val Ala Ala Arg Ala Arg Leu Met Asp Ala Leu Pro     2735 2740 2745 Ala Gly Gly Ala Met Thr Ala Val Glu Ala Gly Glu Asp Glu Val     2750 2755 2760 Thr Pro Leu Leu Thr Asp Gly Val Ala Ile Ala Ala Val Asn Gly     2765 2770 2775 Pro Ala Ala Val Val Val Ser Gly Ala Ala Ala Glu Val Asp Ala     2780 2785 2790 Val Ala Ala Glu Leu Ala Ala Arg Gly Arg Arg Thr Thr Ala Leu     2795 2800 2805 Arg Val Ser His Ala Phe His Ser Pro Leu Met Asp Pro Val Leu     2810 2815 2820 Asp Glu Phe Arg Ala Val Val Arg Asp Leu Gly Tyr Glu Leu Pro     2825 2830 2835 Ala Ile Pro Val Val Ser Leu Leu Ala Gly Ala Gly Ser Pro His     2840 2845 2850 Asp Leu Ala Thr Pro Glu His Trp Val Arg His Val Arg Glu Thr     2855 2860 2865 Val Arg Phe Ala Asp Gly Leu Ala Thr Leu Thr Ala Gly Gly Ala     2870 2875 2880 Thr Ala Phe Leu Glu Ile Gly Pro Asp Gly Val Leu Ser Ala Pro     2885 2890 2895 Ala Arg Ala Val Leu Pro Ala Val Gly Asp Asp Ala Ala Val Val     2900 2905 2910 Thr Pro Ala Leu Arg Ala Gly His Gly Glu Pro Ala Ala Leu Leu     2915 2920 2925 Thr Ala Leu Ala Arg Leu His Val Ala Gly Val Asp Val Asp Trp     2930 2935 2940 Ala Ala Gly Leu Gly Gly Ala Ala Ala Gly Pro Gly Ala Asp Leu     2945 2950 2955 Pro Thr Tyr Ala Phe Gln His Glu Arg Phe Trp Pro Arg Leu Ala     2960 2965 2970 Ala Gly Pro Ala Thr Gly Thr Gly Glu Asp Thr Glu Phe Trp Ala     2975 2980 2985 Ala Val Glu Arg Glu Asp Leu Gly Leu Leu Ala Ala His Leu Asp     2990 2995 3000 Val Asp Gly Glu Arg Leu Gly Ala Val Leu Pro Ala Leu Ala Ala     3005 3010 3015 Trp Arg Ser Arg Arg Arg Ser Asp Ala Ser Leu Asp Arg Leu Arg     3020 3025 3030 Tyr Arg Glu Ser Trp Arg Pro Leu Thr Leu Pro Thr Ala Val Glu     3035 3040 3045 Pro Gly Arg His Leu Val Leu Val Pro Ala Val Ala Ala Gly Asp     3050 3055 3060 Pro Trp Val Gly Glu Val Val Asp Ala Leu Gly Pro Asp Thr Val     3065 3070 3075 Arg Val Asp Leu Asp Gly Thr Gly Thr Asp Arg Ala Gly Leu Ala     3080 3085 3090 Ala Val Leu Thr Gly His Ala Asp Ala Gly Leu Thr Gly Ile Val     3095 3100 3105 Ser Leu Leu Ala Leu Asp Glu Thr Pro Cys Gly Ser Ala Pro Gln     3110 3115 3120 Asp Ala Ala Ser Gly Ala Asp Ala Val Pro Gly Val Asp Ala Val     3125 3130 3135 Pro Ala Gly Leu Ala Ala Thr Ala Ala Leu Ala Ala Ala Leu Ala     3140 3145 3150 Asp Thr Gly Val Thr Thr Arg Val His Ala Val Thr Arg Gly Ala     3155 3160 3165 Val Ala Pro Ala Gly Asp Gly Pro Ala Ala Pro Val Gln Ala Ala     3170 3175 3180 Val Trp Gly Leu Gly Arg Val Ala Ala Leu Glu Leu Pro Arg Arg     3185 3190 3195 Trp Gly Gly Leu Val Asp Leu Pro Ala Glu Leu Asp Ala Ala Thr     3200 3205 3210 Leu Arg Arg Leu Pro Ala Val Leu Ala Gly Glu Glu Asp Gln Val     3215 3220 3225 Ala Leu Arg Ala Thr Gly Ala His Gly Arg Arg Met Thr Pro Ala     3230 3235 3240 Pro Thr Arg Pro Ala Asp Gly Pro Asp Thr Ala Asp Thr Pro Ala     3245 3250 3255 Trp Thr Pro Ser Gly Thr Val Leu Ile Thr Gly Gly Thr Gly Ala     3260 3265 3270 Leu Gly Gly His Val Ala Arg Arg Leu Ala Ala Asp Gly Ala Glu     3275 3280 3285 His Leu Val Leu Leu Gly Arg Arg Gly Pro Asp Ala Pro Gly Val     3290 3295 3300 Asp Ala Leu Arg Ala Glu Leu Glu Ala Ser Gly Ala Ala Val Thr     3305 3310 3315 Val Leu Ala Cys Asp Ala Ala Asp Arg Ala Gln Leu Gln Ala Ala     3320 3325 3330 Leu Ala Ala Ile Pro Ala Asp Arg Pro Leu Thr Gly Val Val His     3335 3340 3345 Ala Ala Gly Val Leu Asp Asp Gly Val Leu Thr Gly Leu Thr Thr     3350 3355 3360 Asp Arg Leu Ala Gly Val Phe His Ala Lys Val Thr Pro Ala Leu     3365 3370 3375 Leu Leu Asp Glu Leu Thr Arg Asp Leu Asp Leu Asp Ala Phe Val     3380 3385 3390 Leu Phe Ser Ser Val Ala Gly Ser Val Gly Asn Pro Gly Gln Ala     3395 3400 3405 Gly Tyr Ala Ala Ala Asn Ala Ala Leu Asp Ala Leu Ala Ala Arg     3410 3415 3420 Arg Val Ala Asp Gly Arg Pro Ala Thr Ala Val Ala Trp Gly Ala     3425 3430 3435 Trp Ala Gly Ala Gly Met Ala Ala Ala His Thr Gly Thr Gly Thr     3440 3445 3450 Val Pro Asp Gly Gln Leu Asp Pro Asp Leu Ala Val Arg Ala Leu     3455 3460 3465 Val Arg Ala Val Ala Glu Pro Ala Pro Thr Leu Val Val Ala Asp     3470 3475 3480 Leu Thr His Pro Arg Leu Leu Glu Ala Leu Leu Ser Val Arg Pro     3485 3490 3495 Ser Pro Leu Leu Ala Asp Leu Pro Ala Ala Arg Asp Ile Ala Arg     3500 3505 3510 Ala Ala Gln Glu Thr Arg Arg Arg Arg Asp Asp Val Ala Gly Gly     3515 3520 3525 Leu Gly Ala Arg Leu Ala Ala Ala Gly Pro Glu Glu Arg Arg Ala     3530 3535 3540 Val Leu Leu Asp Leu Val Arg Asp Thr Ala Ala Gly Val Leu Gly     3545 3550 3555 His Thr Gly Pro Gln Ala Ile Arg Pro Gly Lys Pro Phe Gly Asp     3560 3565 3570 Leu Gly Phe Asp Ser Leu Thr Ala Val Glu Leu Ser Asn Ala Leu     3575 3580 3585 Pro Ala Ala Thr Gly Leu Ser Leu Pro Ala Ser Leu Val Phe Asp     3590 3595 3600 His Pro Thr Pro Arg Val Leu Ala Ala His Leu Val Thr Glu Leu     3605 3610 3615 Thr Gly Asp Thr Gly Gly Ala Asp Gly Ala Gly Pro Val Glu His     3620 3625 3630 Thr Ala Val Asp Gly Asp Asp Pro Val Val Val Val Ala Thr Ala     3635 3640 3645 Cys Arg Phe Pro Gly Gly Val Ser Thr Pro Glu Glu Phe Trp Gln     3650 3655 3660 Leu Leu Ala Asp Gly Gly Asp Gly Ile Thr Gly Phe Pro Thr Asp     3665 3670 3675 Arg Gly Trp Asp Leu Asp Val Leu Ala Gly Asp Gly Gln Gly Arg     3680 3685 3690 Ser Ala Thr Arg Glu Gly Gly Phe Leu His Asp Ala Ala Gly Phe     3695 3700 3705 Asp Pro Ala Phe Phe Asp Ile Ser Pro Arg Glu Ala Val Ala Met     3710 3715 3720 Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Thr Trp Glu Ala Phe     3725 3730 3735 Glu Arg Thr Gly Thr Asp Pro Ala Arg Leu Arg Gly Ser Arg Thr     3740 3745 3750 Gly Val Phe Val Gly Thr Asn Gly Gln Asp Tyr Ala Asn Leu Leu     3755 3760 3765 Leu Arg Ser Pro Asp Asp Val Glu Gly His Ala Gly Thr Gly Leu     3770 3775 3780 Ala Ala Ser Val Ile Ser Gly Arg Leu Ala Tyr Ala Phe Gly Leu     3785 3790 3795 Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu     3800 3805 3810 Val Ala Val His Trp Ala Ala Gln Ala Leu Arg Ala Gly Glu Cys     3815 3820 3825 Asp Ala Ala Leu Ala Gly Gly Val Thr Val Met Ser Thr Ser Thr     3830 3835 3840 Ser Phe Ala Gly Phe Thr Arg Gln Gly Gly Leu Ala Pro Asp Gly     3845 3850 3855 Arg Cys Lys Ala Phe Ser Asp Asp Ala Asp Gly Thr Gly Trp Ser     3860 3865 3870 Glu Gly Val Gly Val Leu Val Leu Glu Arg Gln Ser Thr Ala Leu     3875 3880 3885 Ala Arg Gly His Asp Ile Leu Ala Val Val Arg Gly Ser Ala Val     3890 3895 3900 Asn Ser Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro     3905 3910 3915 Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Ser Gly Gly Leu     3920 3925 3930 Thr Pro Ala Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr     3935 3940 3945 Val Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Ala Tyr     3950 3955 3960 Gly Arg Asp Arg Glu His Pro Leu Leu Leu Gly Ser Val Lys Ser     3965 3970 3975 Asn Ile Gly His Thr Gln Ala Ala Ala Gly Ala Ala Gly Leu Ile     3980 3985 3990 Lys Met Ile Leu Ala Leu Gln His Gly Thr Leu Pro Arg Thr Leu     3995 4000 4005 His Val Thr Asp Pro Ser Ser Arg Val Asp Trp Thr Ala Gly Ala     4010 4015 4020 Val Glu Leu Val Thr Glu Gln Val Pro Trp Pro Glu Thr Gly Arg     4025 4030 4035 Ala Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn     4040 4045 4050 Ala His Val Val Leu Glu Gln Ala Pro Gln Leu Pro Glu Pro Thr     4055 4060 4065 Arg Ala Pro Ala Pro Val Val Thr Pro Trp Val Val Ser Ala Arg     4070 4075 4080 Ser Ala Ala Ala Leu Asp Ala Gln Leu Asp Arg Leu Arg Ala Ala     4085 4090 4095 Thr Gly Gly Pro Asp Leu Thr Thr Ala Ala Glu Val Gly His Ala     4100 4105 4110 Leu Ala Val Gly Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu     4115 4120 4125 Ala Asp Ala Asp Gly Val Thr Glu Val Ala Arg Gly Glu Ala Ala     4130 4135 4140 Glu Arg Ser Thr Ala Phe Leu Phe Ser Gly Gln Gly Ala Gln Arg     4145 4150 4155 Leu Gly Met Gly Arg Ala Leu His Ala Arg His Pro Val Phe Ala     4160 4165 4170 Asp Ala Leu Asp Thr Thr Leu Ala His Leu Asp Pro Thr Val Arg     4175 4180 4185 Ala Val Leu Trp Gly Glu Asp Pro Thr Ala Leu Asp Asp Thr Gly     4190 4195 4200 Val Thr Gln Pro Ala Leu Phe Ala Val Glu Val Ala Leu Phe Arg     4205 4210 4215 Leu Leu Glu Ser Trp Gly Val Thr Ser Asp Ala Val Ala Gly His     4220 4225 4230 Ser Val Gly Glu Val Ala Ala Ala His Val Ala Gly Val Phe Thr     4235 4240 4245 Leu Asp Glu Ala Cys Thr Leu Val Thr Ala Arg Ala Arg Leu Met     4250 4255 4260 Ala Ala Leu Pro Val Gly Gly Ala Met Val Ala Val Glu Ala Asp     4265 4270 4275 Pro Gly Asp Val Thr Pro Leu Leu Thr Gly Gly Val Ala Val Ala     4280 4285 4290 Ala Val Asn Gly Pro Ser Ala Val Val Leu Ser Gly Pro Thr Asp     4295 4300 4305 Glu Val Ser Ala Val Ala Asp Ala Leu Ala Ala Arg Gly Cys Arg     4310 4315 4320 Thr Arg Ala Leu Arg Val Ser His Ala Phe His Ser Pro Leu Met     4325 4330 4335 Glu Pro Met Leu Asp Gly Phe Arg Asp Val Val Ala Gly Leu Asn     4340 4345 4350 Pro Val Glu Pro Arg Ile Pro Val Val Ser Thr Val Thr Gly Ala     4355 4360 4365 Ala Ala Thr Thr Glu Leu Cys Asp Pro Gln His Trp Val Arg Gly     4370 4375 4380 Val Arg Asp Thr Val Arg Phe Ala Asp Ala Val Arg Thr Leu Thr     4385 4390 4395 Gly Ser Gly Ile Thr Ala Phe Leu Glu Ile Gly Pro Asp Ala Val     4400 4405 4410 Leu Ser Ala Pro Thr Arg Ala Cys Val Glu Asp Thr Ala Val Val     4415 4420 4425 Val Pro Ala Leu Arg Gly Pro Asp Thr Glu Glu Arg Ala Leu Leu     4430 4435 4440 Thr Ala Leu Gly Arg Leu His Val Ala Gly Thr Gly Val Asp Trp     4445 4450 4455 Thr Ala Val Leu Ala Gly Thr Ala Ala Gly Arg Val Ala Leu Pro     4460 4465 4470 Thr Tyr Pro Phe Gln Arg Glu Arg Phe Trp Pro Thr Val Ala Ala     4475 4480 4485 Thr Ala Pro Ala Asp Ala Gly Gly Leu Gly Leu Arg Ala Gly Gly     4490 4495 4500 His Pro Leu Leu Gly Ala Ala Thr Thr Val Val Ala Gly Ser Gly Glu     4505 4510 4515 Ile Leu Leu Thr Gly Arg Leu Thr Pro Thr Leu Val Asp Pro Ala     4520 4525 4530 Ala Gly Asp Leu Pro Ala Leu Pro Ala Ala Val Leu Ala Glu Leu     4535 4540 4545 Ala Val Arg Ala Gly Asp Glu Ala Gly Val Thr Thr Val Glu Glu     4550 4555 4560 Leu Thr Ile Thr Ala Pro Leu Gly Ser Gly Thr Ala Gln Leu Leu     4565 4570 4575 Gln Val Arg Val Gly Glu Pro Asp Asp Asp Gly Arg Arg Thr Leu     4580 4585 4590 Ala Val His Ala Arg Ala Ala Asp Asp Pro Asp Gly Pro Trp Thr     4595 4600 4605 Arg His Ala Gly Gly Thr Leu Ser Ala Ala Ala Ala Pro Val Pro     4610 4615 4620 Glu Pro Glu Pro Val Trp Pro Pro Gln Gly Ala Glu Ala Leu Thr     4625 4630 4635 Gly Leu Pro Asp Thr Val Gly Pro Val Arg Val Arg Gly Gly Trp     4640 4645 4650 Arg His Asp Gly Asp Leu Leu Ala Glu Leu Glu Leu Thr Glu Gln     4655 4660 4665 Pro Ala Gly Tyr Thr Leu His Pro Ala Leu Leu Asp Val Ala Val     4670 4675 4680 Arg Phe Gly Ala Ala Thr Asp Val Ala Asp Leu Thr Ala Leu Arg     4685 4690 4695 Gly Leu Thr Leu His Ala Ser Asp Ala Thr Val Leu Arg Val Arg     4700 4705 4710 Leu Thr Asp Arg Gly Asp Gly Thr Arg Ala Leu Ala Ala Trp Asp     4715 4720 4725 Ala Gln Gly Ala Pro Val Leu Thr Ala Gly Glu Leu Thr Leu Ala     4730 4735 4740 Glu Pro Thr Ala Ala Asp Gly Pro Ala Ala Ser Thr Asp Ala Val     4745 4750 4755 Leu Leu Thr Leu Asp Trp Thr Ala Ala Pro Ala Val Asp Arg Ala     4760 4765 4770 Gly Thr Ala Gly Trp Gly Ile Leu Gly Asp Ala Pro Ala Glu Leu     4775 4780 4785 Gly Ala Ala Leu Ala Ala Ser Gly Pro Thr Pro Pro Val Arg Ala     4790 4795 4800 Gly Ser Val Gly Ala Leu Leu Asp Ser Gly Asp Pro Leu Pro Pro     4805 4810 4815 Val Val Leu Ala Pro Ile Thr Gly Ala Pro Ile Thr Gly Ala Pro     4820 4825 4830 Ile Thr Gly Ala Pro Ile Thr Gly Ala Pro Gly Ala Gly Thr Pro     4835 4840 4845 Asp Met Gly Gly Ala Asp Leu Pro Gly Arg Thr Arg Ala Thr Thr     4850 4855 4860 Gly Ala Val Leu Glu Leu Leu Gln Arg Trp Ser Gly Asp Ser Arg     4865 4870 4875 Thr Ala Gly Ser Arg Leu Val Val Val Thr Arg Gly Ala Val Ala     4880 4885 4890 Thr Gly Pro Ala Glu Asp Val His Asp Leu Gly Ala Ala Pro Val     4895 4900 4905 Trp Gly Leu Val Arg Ser Ala Gln Ser Glu Val Pro Gly Ser Met     4910 4915 4920 Leu Leu Leu Asp Leu Asp Pro Ala Asp Pro Gly Ala Gly Pro Asp     4925 4930 4935 Ala Ala Leu Ala Ala Leu Pro Gly Leu Ala Ala Ala Gly Glu Thr     4940 4945 4950 Gln Ala Ala Val Arg Gly Gly Ala Leu Thr Val Ala Arg Leu Thr     4955 4960 4965 Arg Ala Thr Pro Asp Ala Pro Ala Pro Ala Ala Ala Trp Ala Pro     4970 4975 4980 Asp Gly Thr Val Leu Val Thr Gly Gly Thr Gly Gly Leu Gly Ala     4985 4990 4995 Leu Leu Ala Arg His Leu Val Thr Thr Arg Gly Val Arg His Leu     5000 5005 5010 Leu Leu Ala Gly Arg Arg Gly Pro Asp Ala Pro Gly Ala Ala Gln     5015 5020 5025 Leu Arg Ala Glu Leu Ala Ala Leu Gly Ala Glu Val Thr Leu Ala     5030 5035 5040 Ala Cys Asp Val Ala Asp Pro Ala Ala Val Ala Glu Leu Val Gly     5045 5050 5055 Ala Val Pro Ala Ala His Pro Leu Thr Ala Val Val His Thr Ala     5060 5065 5070 Gly Val Leu Asp Asp Ala Thr Val Gly Ser Leu Asp Ala Ala Arg     5075 5080 5085 Met Asp Arg Val Leu Arg Pro Lys Ala Asp Ala Ala Trp His Leu     5090 5095 5100 His Glu Ala Thr Arg Asp Leu Pro Leu Ala Ala Phe Val Leu Tyr     5105 5110 5115 Ser Ser Val Ala Gly Ile Thr Gly Gly Pro Gly Gln Gly Asn Tyr     5120 5125 5130 Ala Ala Ala Asn Thr Leu Leu Asp Ala Leu Ala Ala His Arg Ala     5135 5140 5145 Ala His Gly Leu Pro Gly Leu Ser Leu Ala Trp Gly Pro Trp Ser     5150 5155 5160 Ala Asp Ala Gly Met Thr Gly Thr Leu Asp Ala Ala Glu Arg Glu     5165 5170 5175 Arg His Glu Arg Ser Gly Met Pro Pro Leu Gln Pro Ala Gln Gly     5180 5185 5190 Leu Ala Leu Phe Asp Thr Ala Leu Ala Arg Gly Asp Arg Phe Ala     5195 5200 5205 Val Ala Ala Arg Phe Ala Ala Gly Ala Gly Thr Ala Val Asp Asp     5210 5215 5220 Val Pro Ala Val Leu Arg Ala Leu Val Arg Ser Met Arg Arg Thr     5225 5230 5235 Ala Ala Ala Thr Glu Gly Ala Gly Gly Leu Leu Arg Arg Leu Ala     5240 5245 5250 Gly Met Glu Pro Gly Ala Arg His Ala Glu Leu Leu Ala Leu Val     5255 5260 5265 Arg Ala Glu Thr Ala Ala Val Leu Gly His Thr Gly Ala Glu Ala     5270 5275 5280 Val Pro Ala Asp Arg His Phe Ser Arg Leu Gly Phe Asp Ser Leu     5285 5290 5295 Thr Gly Leu Glu Leu Arg Met Arg Leu Ala Ala Ala Thr Gly Ser     5300 5305 5310 Arg Leu Pro Ala Thr Leu Val Phe Asp His Pro Thr Pro Ala Glu     5315 5320 5325 Val Ala Arg His Leu Asp Glu Glu Val Leu Gly Ser Ala Asp Arg     5330 5335 5340 Gly Ala Ser Ser Pro Leu Ala Glu Leu Asp Arg Leu Glu Ala Ala     5345 5350 5355 Leu Ser Pro Asp Gly Ala Asp Ala Glu Thr Arg Ser Gly Val Ala     5360 5365 5370 Arg Arg Leu Arg Arg Leu Leu Glu Gln Trp Asp Gly Ala Arg Thr     5375 5380 5385 Asp Gly Ala Asp Pro Asp Gly Arg Thr Ala Val Asp Glu Arg Leu     5390 5395 5400 Glu Ser Ala Ser Thr Glu Gln Val Leu Ala Phe Ile Asp Asn Glu     5405 5410 5415 Leu Gly Arg Ser Ser Ala Arg     5420 5425 <210> 8 <211> 2031 <212> PRT <213> Pseudonocardia autotrophica <400> 8 Met Pro Asp Glu Gln Lys Leu Val Asp Tyr Leu Lys Trp Val Thr Ala 1 5 10 15 Asp Leu His Asp Thr Arg Arg Arg Leu Ala Glu Ala Glu Ala Ala Arg             20 25 30 His Glu Pro Val Ala Ile Val Gly Met Ala Cys Arg Phe Pro Gly Gly         35 40 45 Val Arg Ser Pro Glu Asp Leu Trp Glu Leu Leu Thr Ala Gly Arg Asp     50 55 60 Gly Ile Gly Pro Phe Pro Asp Asp Arg Gly Trp Asp Leu Asp Ala Leu 65 70 75 80 Ala Gly Asp Gly Pro Ala Ala Ser Ala Thr Gln Arg Gly Gly Phe Leu                 85 90 95 Pro Gly Ala Ala Glu Phe Asp Pro Ala Phe Phe Asp Ile Ser Pro Arg             100 105 110 Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ala         115 120 125 Trp Glu Ala Phe Glu Arg Ser Gly Ile Asp Pro Ala Gly Leu Arg Gly     130 135 140 Ser Arg Thr Gly Val Phe Val Gly Thr Asn Gly Gln Asp Tyr Thr His 145 150 155 160 Leu Val Leu Ala Ser Ala Asp Asp Met Gly Gly Tyr Ala Gly Asn Gly                 165 170 175 Leu Ala Ala Ser Val Leu Ser Gly Arg Val Ser Phe Ala Leu Gly Leu             180 185 190 Gln Gly Pro Ala Val Thr Leu Asp Thr Ala Cys Ser Ser Ala Leu Val         195 200 205 Gly Met His Leu Ala Ala Gln Ala Val Arg Ser Gly Glu Cys Gly Leu     210 215 220 Ala Leu Ala Gly Gly Val Thr Val Met Thr Thr Pro Ala Asn Phe Ser 225 230 235 240 Gly Phe Ser Leu His Gly Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala                 245 250 255 Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Ile Gly Leu             260 265 270 Leu Val Val Glu Lys Leu Ala Asp Ala Arg Ala His Gly His Pro Val         275 280 285 Leu Ala Val Leu Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn     290 295 300 Gly Leu Ser Ala Pro Asn Gly Pro Ala Gln Gln Arg Val Ile Arg Gln 305 310 315 320 Ala Leu Ala Ser Gly Gly Leu Ser Pro Ala Asp Val Asp Ala Val Glu                 325 330 335 Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln Ala             340 345 350 Leu Leu Ala Thr Tyr Gly Ala Asp Arg Asp Pro Asp Arg Pro Leu Leu         355 360 365 Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly     370 375 380 Ala Ala Gly Val Ile Arg Thr Val Leu Ala Leu Gln His Arg Thr Leu 385 390 395 400 Pro Arg Thr Leu His Val Asp Ala Pro Ser Ser His Val Asp Trp Ser                 405 410 415 Ala Gly Ala Val Arg Leu Leu Thr Gly Gln Thr Ala Trp Pro Asp Thr             420 425 430 Gly Arg Ala Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr         435 440 445 Asn Ala His Val Val Leu Glu Gln Ala Pro Thr Asp Pro Ala Glu Pro     450 455 460 Thr Gly Ser Thr Val Pro Thr Gly Pro Ala Val Arg Pro Gln Ala Val 465 470 475 480 Ala Trp Pro Val Ser Ala Arg Ser Ala Thr Ala Leu Asp Ala Gln Leu                 485 490 495 Glu Arg Val Arg Ala Leu Ala Ala Ala Pro Val Pro Ala Asp Val Gly             500 505 510 Gln Ala Leu Ala Thr Thr Arg Thr Pro Phe Ala His Arg Ala Leu Leu         515 520 525 Val His Thr Gly Asp Gly Leu Thr Glu Ala Ala Arg Asp Val Val Pro     530 535 540 Thr Gly Asp Arg Gly Gly Leu Ala Val Leu Phe Ser Gly Gln Gly Ser 545 550 555 560 Gln Arg Leu Gly Ala Gly Cys Glu Leu His Ala Arg Phe Ala Val Phe                 565 570 575 Ala Ala Ala Phe Asp Glu Thr Val Ala Leu Leu Asp Ala Arg Leu Gly             580 585 590 Ala Ser Leu Arg Glu Val Val Trp Gly Ser Asp Arg Ala Ala Leu Asp         595 600 605 Asp Thr Arg Phe Thr Gln Pro Ala Leu Phe Ala Thr Glu Val Ala Leu     610 615 620 His Arg Leu Val Glu Ser Trp Gly Val Arg Pro Gly His Val Gly Gly 625 630 635 640 His Ser Val Gly Glu Ile Thr Ala Ala His Val Ala Gly Ile Leu Ser                 645 650 655 Leu Asp Asp Ala Cys Thr Leu Val Ala Ala Arg Ala Arg Leu Met Ala             660 665 670 Asp Leu Pro Ala Gly Gly Ala Met Val Ala Leu Gln Ala Arg Glu Asp         675 680 685 Glu Val Ala Pro Leu Leu Gly Asp Asp Val Ala Ile Ala Ala Val Asn     690 695 700 Gly Pro Asp Ala Val Val Val Ser Gly Asp Ala Asp Ala Val Ala Ala 705 710 715 720 Val Ala Ala Arg Phe Glu Asp Arg Gly Arg Arg Ile Arg Thr Leu Ser                 725 730 735 Val Ser His Ala Phe His Ser Pro Leu Ile Asp Pro Met Leu Ala Glu             740 745 750 Phe Ala Arg Val Val Asp Gly Leu Thr Phe Ala Glu Pro Arg Ile Pro         755 760 765 Val Val Ser Asn Leu Thr Gly Glu Val Ser Gly Glu Leu Thr Asp Pro     770 775 780 Gly Tyr Trp Val Arg His Ala Arg Gly Ala Val Arg Phe Gly Asp Gly 785 790 795 800 Val Ala Ala Leu Ala Gly Leu Gly Val Arg Thr Phe Leu Glu Leu Gly                 805 810 815 Pro Asp Ala Val Leu Ser Ala Leu Val Ala Glu Asn Ala Pro Gly Ala             820 825 830 Val Ala Val Pro Ala Leu Arg Arg Gly Ala Gly Glu Glu Ala Thr Leu         835 840 845 Leu Val Ala Ala Gly Ala Leu Trp Thr Arg Gly Thr Asp Val Asp Trp     850 855 860 Ala Ala Val Ala Glu Gly Thr Thr Thr Pro Gly Ala Ala Pro Val Thr 865 870 875 880 Leu Pro Thr Tyr Ala Phe Asp Arg Glu Arg Tyr Trp Pro Thr Leu Arg                 885 890 895 Ala Ala Thr Gly Asp Ala Ala Gly Leu Gly Leu Thr Ala Ala Gly His             900 905 910 Pro Leu Leu Gly Ala Ala Val Val Leu Ala Asp Ala Asp Arg Thr Val         915 920 925 Leu Thr Gly Arg Leu Ser Pro Arg Thr Gln Pro Trp Leu Gly Pro Glu     930 935 940 Arg Thr Asp Gly Arg Val Asp Val Pro Gly Ala Val Phe Ala Glu Leu 945 950 955 960 Ala Ile Arg Ala Gly Asp Gln Val Gly Ala Pro His Ile Ala Glu Leu                 965 970 975 Asp Leu Leu Ala Pro Leu Ala Val Gly Arg Asp Gly Ala Val Leu Gln             980 985 990 Val Gly Val Gly Ala Pro Gly Asp Arg Gly Arg Arg Asp Leu Thr Val         995 1000 1005 His Ala Arg Ser Ser Asp Asp Ala Pro Trp Thr Leu His Ala Arg     1010 1015 1020 Gly Val Leu Ala His Glu Ala Asp Arg Val Gly Thr Thr Asp Pro     1025 1030 1035 Gly Glu Trp Pro Pro Arg Asp Ala Arg Ala Val Pro Ala Arg Asp     1040 1045 1050 Thr Gly Pro Asp Gln Val Trp Val Arg Asp Gly Glu Val Leu Ala     1055 1060 1065 Glu Val Thr Leu Pro Thr Gly Ala Ala Ala Asp Gly Tyr Gly Leu     1070 1075 1080 His Pro Ala Leu Leu Gly Ala Ala Leu Ala Thr Ala Ser Ala Leu     1085 1090 1095 Asp Gly Gly Pro Thr Ala Thr Ala Asp Pro Gly Ala Gly Pro Ala     1100 1105 1110 Arg Ile Glu Gly Leu Thr Leu His Ala Thr Gly Ala Thr Thr Leu     1115 1120 1125 Arg Val Arg Leu Thr Gly Thr Gly Thr Gly Thr Phe Gly Leu Val     1130 1135 1140 Ala Thr Asp Pro Thr Gly Ala Pro Val Leu Thr Ala Asp Ala Val     1145 1150 1155 His Thr Gly Thr Gly Asp Thr Gln Ala Pro Ala Ala Thr Gly Gln     1160 1165 1170 Gly Gly Leu Phe Gly Leu His Trp Thr Pro Val Glu Leu Gly Asp     1175 1180 1185 Arg Ala Ala Gly Thr Arg Trp Ala Val Val Gly Asp Asp Glu Leu     1190 1195 1200 Asp Leu Gly Tyr Ala Met His Arg Ala Asp Glu Thr Val Ser Ala     1205 1210 1215 Tyr Ala Glu Ser Leu Gly Gly Ala Val Gly Asp Thr Gly Leu Ala     1220 1225 1230 Pro Asp Val Phe Leu Ile Pro Val Val Gly Asp Pro Asp Gly Gly     1235 1240 1245 Ala Ala Ala Val His Thr Leu Thr Thr Arg Val Leu Gly Leu Leu     1250 1255 1260 Gln Glu Trp Leu Ala Glu Pro Arg Leu Ala Asp Ala Arg Leu Val     1265 1270 1275 Val Val Thr Arg Gly Ala Val Ala Ala Asp Gly Glu Thr Val Thr     1280 1285 1290 Asp Pro Ala Ala Ala Ala Val Trp Gly Leu Val Arg Ala Ala Gln     1295 1300 1305 Thr Glu Asn Pro Gly Arg Ile Arg Leu Val Asp Leu Asp Asp Thr     1310 1315 1320 Phe Arg Ser Ala Gly Val Leu Pro His Leu Leu Leu Leu Asp Glu     1325 1330 1335 Gln Gln Leu Leu Val Arg Glu His Glu Val Arg Ala Ala Arg Leu     1340 1345 1350 Ala Arg Leu Pro Glu Ile Ala Pro Asp Thr Val Pro Asp Thr Ala     1355 1360 1365 Arg Thr Ala Ala Asp Trp Asp Pro Asp Gly Thr Val Leu Val Thr     1370 1375 1380 Gly Gly Thr Gly Gly Leu Gly Ala Leu Leu Ala Arg His Leu Val     1385 1390 1395 Thr Thr Gly Arg Thr Arg Asn Leu Leu Leu Ala Ser Arg Arg Gly     1400 1405 1410 Pro Asp Ala Pro Gly Ala Ala Glu Leu Cys Glu Glu Leu Thr Glu     1415 1420 1425 Leu Gly Ala Ala Val Ala Val Thr Ala Cys Asp Ala Gly Asp Pro     1430 1435 1440 Asp Ala Val Ala Ala Leu Val Gly Ser Val Pro Ala Gly His Pro     1445 1450 1455 Leu Thr Ala Val Val His Thr Ala Gly Val Leu Asp Asp Gly Leu     1460 1465 1470 Thr Gly Ser Leu Thr Pro Glu Arg Leu Ala Gly Val Leu Arg Pro     1475 1480 1485 Lys Leu Asp Ala Ala Trp His Leu His Ala Ala Thr Arg Glu Leu     1490 1495 1500 Pro Leu Ala Gly Phe Val Leu Tyr Ser Ser Val Ser Gly Ile Leu     1505 1510 1515 Gly Ser Ala Gly Gln Ala Asn Tyr Ala Ala Ala Asn Ala Gly Leu     1520 1525 1530 Asp Gly Leu Ala Gly Tyr Arg Ala Gly Leu Gly Leu Pro Ala Val     1535 1540 1545 Ser Leu Gly Trp Gly Pro Trp Gly Arg Gly Ser Gly Met Thr Glu     1550 1555 1560 Gln Val Thr Asp Ala Asp Leu Asp Arg Met Ala Arg Gly Gly Leu     1565 1570 1575 Pro Ala Leu Asp Ala Ala Asp Gly Leu Ala Leu Phe Asp Ala Ala     1580 1585 1590 Leu Ala Arg Pro Glu Pro Val Val Val Pro Thr Arg Ile Asn Val     1595 1600 1605 Ala Gly Leu Ala Val Gln Gln Ala Leu Pro Ala Leu Trp Arg Asp     1610 1615 1620 Leu Val Pro Arg Thr Arg Arg Thr Ala Ala Val Ala Gly Ser Ser     1625 1630 1635 Pro Val Thr Val Arg Glu Arg Leu His Arg Leu Asp Ala Ala Gly     1640 1645 1650 Arg Glu Ala Leu Leu Val Glu Leu Val Thr Gly Tyr Thr Ala Gly     1655 1660 1665 Leu Leu Gly His Glu Asp Ala Ala Ala Val Asp Pro Glu Arg Gly     1670 1675 1680 Phe Leu Glu Leu Gly Phe Asp Ser Leu Val Ala Val Gly Leu Arg     1685 1690 1695 Asn Gln Leu Gly Glu Val Leu Gly Leu Arg Leu Ala Gly Ser Ile     1700 1705 1710 Val Phe Asp Ser Thr Thr Pro Val Lys Leu Ala Arg Arg Leu His     1715 1720 1725 Glu Leu Val Glu Gln Ala Pro Ala Pro Gly Ala Ser Pro Ala Val     1730 1735 1740 Val Ala Gly Arg Pro Ala Gln Pro Gly Glu Glu Thr Leu Val Gly     1745 1750 1755 Leu Phe His Ala Ala Val Arg Gly Gly Lys Leu Val Glu Ala Met     1760 1765 1770 Arg Met Leu Lys Ala Ala Ala Asn Thr Arg Pro Met Phe Glu Ser     1775 1780 1785 Pro Ala Glu Leu Glu Glu Leu Ser Glu Pro Val Thr Leu Ala Glu     1790 1795 1800 Gly Pro Ala Ala Pro Arg Leu Ile Phe Val Ser Ala Pro Gly Ala     1805 1810 1815 Thr Gly Gly Val His Gln Tyr Ala Arg Ile Ala Ala His Phe Arg     1820 1825 1830 Gly Ser Arg His Val Ser Ala Leu Pro Leu Met Gly Phe Ala Pro     1835 1840 1845 Gly Glu Leu Leu Pro Ala Thr Ser Glu Ala Ala Ala Arg Ile Val     1850 1855 1860 Ala Glu Ser Val Leu Leu Ala Ser Asp Gly Glu Pro Phe Val Met     1865 1870 1875 Val Gly His Ser Thr Gly Gly Ser Leu Ala Tyr Leu Ala Ala Gly     1880 1885 1890 Val Leu Glu Glu Thr Trp Gly Val Arg Pro Glu Ala Val Val Leu     1895 1900 1905 Leu Asp Thr Ala Ser Ile Arg Trp Asp Ala Ala Glu Gly Asn Asp     1910 1915 1920 Leu Asp Arg Thr Thr Arg Phe Tyr Leu Ala Asp Ile Asp Ser Pro     1925 1930 1935 Ser Val Thr Leu Asn Ser Ala Arg Met Ser Ala Met Ala His Trp     1940 1945 1950 Phe Met Thr Met Thr Glu Ile Asp Ser Pro Pro Thr Thr Ala Pro     1955 1960 1965 Thr Leu Leu Val Arg Ala Ala Arg Asp Val Glu Gly Phe Ile Leu     1970 1975 1980 Asp Thr Ser Ala Val Pro Ala Asp Thr Val Val Asp Ile Asp Ala     1985 1990 1995 Asp His Leu Ser Leu Ala Met Glu His Ser Ala Leu Thr Ala Asp     2000 2005 2010 Ala Ile Glu Thr Trp Leu Ala Glu Leu Pro Thr Pro Thr Thr Glu     2015 2020 2025 Asp Ala Ser     2030 <210> 9 <211> 403 <212> PRT <213> Pseudonocardia autotrophica <400> 9 Met Thr Ser Pro Thr Thr Cys Pro Val Thr Gly Gly Gly Pro Pro Pro 1 5 10 15 Ser Leu Glu Gly Gln Thr Pro Pro Val Leu Arg Leu Ser Pro Leu Leu             20 25 30 Arg Glu Leu Gln Gln Gln Ala Pro Val Cys Arg Val Arg Thr Pro Thr         35 40 45 Gly Asp Glu Ala Trp Leu Val Thr Arg Tyr Ala Glu Leu Lys Ala Leu     50 55 60 Leu His Asp Glu Arg Leu Gly Arg Ala His Ala Asp Pro Ala Asn Ala 65 70 75 80 Pro Arg Tyr Val Arg Asn Pro Phe Leu Asp Leu Leu Val Val Asp Asp                 85 90 95 Ala Gln Gln Ala Arg Asp Leu His Thr Glu Met Arg Arg Leu Leu Thr             100 105 110 Pro Gln Phe Ser Ala Arg Arg Val Leu Gly Leu Ala Pro Thr Val Ser         115 120 125 Ala Val Ala Glu Gln Val Leu Asp Gly Phe Val Ala Ala Gly Asn Pro     130 135 140 Gly Asp Leu His Gly Gly Phe Ser Met Leu Ala Thr Arg Met Thr Val 145 150 155 160 Leu Cys Glu Leu Ile Gly Ile Pro Pro Gln Asp Arg Pro Glu Thr Gly                 165 170 175 Ala Cys Thr Ile Met Thr Met Gly Glu Val Asp Asp Val Glu Arg Val             180 185 190 Ala Thr Val Gln Ala Glu Leu Phe Gly Leu Leu Ser Ala Val Pro Arg         195 200 205 Arg Lys Arg Ala Glu Pro Thr Asp Asp Val Val Ser Arg Leu Phe Ala     210 215 220 Gln Val Pro Asp Glu Arg Ile Gly Pro Ile Ala Ala Gly Val Leu Leu 225 230 235 240 Ala Gly Leu Asp Ser Val Pro Ser His Val Asp Leu Gly Val Leu Leu                 245 250 255 Phe Ala Thr His Pro Asp Gln Leu Ala Ala Ala Leu Ala Asp Glu Arg             260 265 270 Thr Met Arg Glu Gly Val Glu Glu Ile Leu Arg Cys Ala Lys Ala Gly         275 280 285 Gly Ser Val Leu Pro Arg Tyr Ala Thr Asp Asp Val Glu Ile Gly Gly     290 295 300 Val Thr Leu Arg Thr Gly Asp Leu Val Leu Leu Asp Phe Thr Leu Val 305 310 315 320 Asn Phe Asp Thr Gln Val Phe Asp Glu Pro Glu Val Phe Asp Ile Arg                 325 330 335 Arg Glu Ser Asn Pro His Leu Thr Phe Gly His Gly Met Trp His Cys             340 345 350 Ile Gly Ala Pro Leu Ala Arg Met Ala Leu Arg Thr Ala Phe Thr Arg         355 360 365 Leu Phe Thr Arg Leu Pro Asp Leu Arg Pro Ala Arg Pro Val Gln Glu     370 375 380 Met Arg Arg Gly Ser Glu Gly Leu Ser Gly Gly Leu Thr Glu Leu Pro 385 390 395 400 Val Thr Trp              <210> 10 <211> 413 <212> PRT <213> Pseudonocardia autotrophica <400> 10 Met Ser Thr Gly Thr Ala Arg Ser Thr Pro Ser Asp Thr Ala Thr Gly 1 5 10 15 Cys Pro Val Thr Gly Ala Gly Ala Gly Ala Ala Thr Cys Pro Val Ala             20 25 30 Phe Pro Leu Arg Arg Pro Gly Arg Pro Phe Pro Pro Pro Glu Tyr Ala         35 40 45 Asp Tyr Arg Asp Gly Gly Glu Pro Val Arg Ser Glu Leu Pro Ser Gly     50 55 60 Pro Val Trp Leu Val Thr Arg His Ala Asp Val Arg Ala Val Leu Thr 65 70 75 80 Asp Pro Arg Ile Ser Ala Asp Pro Ser Arg Pro Gly Phe Pro Lys Ala                 85 90 95 Ala Arg Thr Gly Gly Ala Pro Ser Ala Asp Glu Val Pro Gly Trp Phe             100 105 110 Val Ser Met Asp Pro Pro Glu His Asp Arg Phe Arg Arg Thr Leu Ile         115 120 125 Pro Glu Phe Thr Val Arg Lys Val Arg Ala Leu Arg Pro Glu Ile Gln     130 135 140 Gln Ile Val Asp Asp Arg Ile Glu Ala Ile Leu Ala Lys Asp Gly Ala 145 150 155 160 Ala Asp Leu Ile Glu Asp Phe Ala Leu Pro Val Pro Ser Leu Val Ile                 165 170 175 Ala Gly Met Leu Gly Val Pro Arg Ala Asp Arg Asp Phe Phe Glu Ala             180 185 190 Lys Thr Arg Val Leu Val Thr Leu Ser Ser Ser Asp Glu Glu Arg Asp         195 200 205 Ala Ala Thr Ala Ala Leu Leu Arg Tyr Leu Gly Arg Leu Ile Arg Ile     210 215 220 Lys Glu Arg Arg Pro Gly Thr Asp Leu Ile Ser Arg Leu Ala Ala Thr 225 230 235 240 Gly Thr Leu Ser Arg Gln Glu Leu Ser Gly Val Ala Met Leu Leu Leu                 245 250 255 Ile Ala Gly His Glu Thr Thr Ala Asn Asn Ile Gly Leu Gly Ile Val             260 265 270 Gln Leu Leu Thr Asn Pro Gln Trp Ile Gly Asp Asp Arg Val Val Glu         275 280 285 Glu Leu Leu Arg Tyr Tyr Ser Val Ala Asp Leu Val Ala Phe Arg Val     290 295 300 Ala Leu Ala Asp Val Glu Ile Gly Gly Arg Thr Ile Arg Ala Gly Glu 305 310 315 320 Gly Ile Leu Pro Leu Leu Ala Ala Ala Asn His Asp Asp Asp Ala Phe                 325 330 335 Asp Gly Ala Gly Ala Phe Asp Pro Glu Arg Ser Ala Arg Ser His Val             340 345 350 Ala Phe Gly Tyr Gly Val His Gln Cys Leu Gly Gln Asn Leu Val Arg         355 360 365 Leu Glu Met Glu Ile Ala Tyr Arg Thr Leu Phe Asp Arg Ile Pro Thr     370 375 380 Leu Arg Leu Ala Val Pro Ala Asp Asp Leu Arg Val Lys Tyr Asp Gly 385 390 395 400 Val Leu Phe Gly Leu His Glu Leu Pro Val Thr Trp Gly                 405 410 <210> 11 <211> 352 <212> PRT <213> Pseudonocardia autotrophica <400> 11 Met Ser Phe Thr Gln Pro Val Ser Lys Pro Trp Leu Asp Gly His Glu 1 5 10 15 Leu Asp Tyr Val Thr Asp Ala Val Gly Gly Gly Trp Ile Ser Ser Gln             20 25 30 Gly Pro Tyr Ile Ala Arg Phe Glu Glu Ala Phe Ala Ala Trp Asn Gly         35 40 45 Val Pro His Gly Val Ala Cys Ser Ser Gly Thr Thr Ala Leu Thr Leu     50 55 60 Ala Leu Arg Ala Leu Gly Val Gly Pro Gly Asp Glu Val Ile Val Pro 65 70 75 80 Glu Phe Thr Met Ile Ala Ser Ala Trp Ala Val Thr Tyr Thr Gly Ala                 85 90 95 Thr Pro Val Phe Val Asp Cys Gly Asp Asp Leu Asn Ile Asp Val Thr             100 105 110 Leu Leu Glu Glu Lys Ile Thr Pro Arg Thr Arg Val Ile Met Pro Val         115 120 125 His Val Tyr Gly Arg Arg Cys Asp Met Glu Pro Ile Leu Glu Leu Ala     130 135 140 Tyr Glu Tyr Asn Leu Arg Val Val Glu Asp Ser Ala Glu Ala His Gly 145 150 155 160 Val Leu Pro Thr Gly Asp Ile Ala Cys Phe Ser Leu Phe Ala Asn Lys                 165 170 175 Ile Ile Thr Ala Gly Glu Gly Gly Ile Cys Val Thr Arg Asp Pro His             180 185 190 Leu Ala Glu Gln Met Ala His Leu Arg Ala Met Ala Phe Thr Arg Asp         195 200 205 His Ser Phe Leu His Lys Lys Leu Ala Tyr Asn Tyr Arg Met Thr Asn     210 215 220 Met Gln Ala Ala Val Ala Leu Ala Gln Thr Glu Gln Leu Glu Gly Ile 225 230 235 240 Leu Ala Thr Arg Arg Asp Ile Glu Lys Arg Tyr Asp Asp Ala Leu Arg                 245 250 255 Asp Val Pro Gly Ile Thr Leu Met Pro Pro Arg Asp Val Leu Trp Met             260 265 270 Tyr Asp Leu Arg Ala Glu Arg Arg Asp Glu Leu Leu Ala His Leu Ala         275 280 285 Ala Arg Gly Ile Asp Thr Arg Val Phe Phe Lys Pro Met Ser Arg Gln     290 295 300 Pro Met Tyr Leu Asp Pro Val Trp Pro Thr Leu Asn Ala Ser Arg Leu 305 310 315 320 Ala Ala Asp Gly Phe Tyr Leu Pro Thr His Thr Gly Leu Thr Ala Glu                 325 330 335 Asp Gln Glu Phe Ile Thr Gly Gln Val Arg Ala Phe Tyr Gly Val Ala             340 345 350 <210> 12 <211> 489 <212> PRT <213> Pseudonocardia autotrophica <400> 12 Met Arg His Ala Thr Gly His Pro Ala Arg His Ser Arg Arg Gly Cys 1 5 10 15 Leu Pro Met Gly Ala Asn Arg Arg Pro Ile Leu Phe Val Ser Tyr Ala             20 25 30 Glu Ser Gly Leu Leu Asn Pro Leu Leu Val Leu Ala Gly Glu Leu Ser         35 40 45 Arg Arg Glu Val Gly Asp Leu Tyr Phe Ala Ala Asp Glu Lys Ala Arg     50 55 60 Asp Asp Val Ala Gly Ala Ser Thr Gly Ser Pro Val Thr Phe Ala Ser 65 70 75 80 Leu Gly Asp Thr Val Ser Glu Met Ser Ala Val Thr Trp Asp Asp Glu                 85 90 95 Thr Tyr Ala Ala Val Thr Gln Arg Asp Arg Phe Arg Ala His Ala Ala             100 105 110 Val Ile Arg His Ser Phe Ala Pro Glu Ser Arg Ile Glu Lys Tyr Arg         115 120 125 Ala Leu Glu Arg Val Val Asp Glu Val Arg Pro Ala Leu Met Val Ile     130 135 140 Glu Ser Met Cys Gln Tyr Gly Tyr Glu Leu Ala Ile Thr Lys Gly Ile 145 150 155 160 Pro Phe Val Leu Gly Val Pro Phe Val Pro Ser Asn Val Leu Thr Ser                 165 170 175 His Val Pro Phe Ala Arg Ser Tyr Thr Pro Ser Gly Phe Pro Val Pro             180 185 190 His Ser Gly Leu Pro Ala Thr Met Thr Leu Arg Gln Lys Ile Ala Asn         195 200 205 Gln Leu Phe Arg Ile Arg Thr Leu Gly Met Phe Val Thr Lys Glu Thr     210 215 220 Arg Lys Val Val Glu Arg Asp Asp Ala Val Arg Ala Glu Leu Gly Ile 225 230 235 240 Ala Pro Glu Ala Arg Gln Met Met Ala Arg Ile Asp His Ala Glu Gln                 245 250 255 Val Leu Cys Tyr Ser Val Pro Glu Leu Asp Tyr Pro Phe Glu Leu Pro             260 265 270 Glu Arg Met Arg Leu Val Gly Thr Met Val Pro Pro Leu Pro Gln Val         275 280 285 Ala Asp Gly Gly Glu Leu Thr Asp Trp Leu Asp Ala Gln Ser Ser Val     290 295 300 Val Tyr Met Gly Phe Gly Thr Ile Thr Arg Leu Thr Arg Pro Gln Val 305 310 315 320 Ala Ser Leu Val Glu Val Ala Arg Arg Leu Asp Ala Arg Gly His Gln                 325 330 335 Val Leu Trp Lys Leu Pro Arg Glu Gln Gln Glu Met Leu Pro Pro Ala             340 345 350 Thr Glu Leu Pro Ala Gly Leu Arg Ile Glu Ser Trp Val Pro Ser Gln         355 360 365 Leu Asp Val Leu Ala His Pro Ser Val Lys Val Phe Phe Thr His Ala     370 375 380 Gly Gly Asn Gly Tyr His Glu Gly Leu Tyr Phe Gly Lys Pro Leu Val 385 390 395 400 Val Arg Pro Leu Trp Val Asp Cys Asp Asp Gln Ala Ile Arg Gly Gln                 405 410 415 Asp Phe Gly Val Ser Leu Thr Val Asp His Pro Glu Thr Val Asp Thr             420 425 430 Asp Asp Val Leu Asp Lys Val Thr Arg Val Leu Glu Thr Pro Ala Phe         435 440 445 Thr Glu Arg Ala Ala Arg Met Gly Arg Leu Leu His Glu Ala Gly Gly     450 455 460 Arg Ala Ala Ala Ala Asp Leu Ile Leu Arg Leu Pro Val Leu Ala Gly 465 470 475 480 Thr Asp Ala Pro Ala Ala Arg Thr Ala                 485 <210> 13 <211> 1097 <212> PRT <213> Pseudonocardia autotrophica <400> 13 Met Thr Ala Gly His Gly Ser Asp Pro Val Val Val Val Gly Met Ala 1 5 10 15 Cys Arg Tyr Pro Gly Gly Val Arg Asp Ala Asp Gly Leu Trp Asp Leu             20 25 30 Leu Cys Ser Asp Arg Glu Thr Ala Ser Gly Phe Pro Asp Asp Arg Gly         35 40 45 Trp Asp Leu Asp Ala Leu His Gly Asp Gly Pro Gly Arg Cys Ala Thr     50 55 60 Arg Thr Ala Gly Phe Leu Asp Gly Ala Gly Asp Phe Asp Ala Ala Phe 65 70 75 80 Phe Gly Met Ser Pro Arg Glu Ala Val Ser Thr Asp Pro Gln Gln Arg                 85 90 95 Leu Val Leu Glu Thr Ala Trp Glu Ala Val Glu His Ala Gly Ile Asp             100 105 110 Pro Ser Ser Leu Arg Gly Thr Arg Thr Gly Val Phe Val Gly Ala Gly         115 120 125 Gly Gln Asp Tyr Ala Gly Val Val Gln Asn Ser Pro Asp Asp Leu Ala     130 135 140 Gly His Ala Leu Thr Gly Leu Ile Pro Gly Leu Thr Ser Gly Arg Leu 145 150 155 160 Ala His Leu Leu Gly Leu Glu Gly Pro Ala Leu Thr Val Asp Thr Thr                 165 170 175 Ser Ser Ser Ser Leu Val Ala Leu His Leu Ala Ile Arg Ser Leu Asp             180 185 190 Ala Gly Glu Cys Thr Ala Ala Leu Ala Gly Gly Val Cys Val Met Ser         195 200 205 Thr Pro Ala Ala Leu Val Gly His Ser Arg Gln Gly Gly Leu Ala Pro     210 215 220 Asp Gly Arg Ala Lys Val Phe Ala Asp Asp Ala Asp Gly Thr Ala Trp 225 230 235 240 Ala Glu Gly Val Gly Val Val Leu Leu Lys Arg Leu Ser His Ala Arg                 245 250 255 Ala Asp Gly Asp Pro Val Leu Ala Val Leu Arg Gly Ser Ala Leu Thr             260 265 270 Ala Asp Gly Ala Thr Asp Gly Leu Thr Ala Pro Ser Gly Ala Ala Gln         275 280 285 Glu Arg Met Ile Arg Asp Ala Leu Ala Asp Ala Gly Leu Thr Ala Ala     290 295 300 Glu Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Pro Val Gly Asp 305 310 315 320 Pro Val Glu Ala Arg Ala Leu Leu Ala Thr Tyr Gly Gln Asp Arg Asp                 325 330 335 Pro Gly Arg Pro Leu Trp Val Gly Ser Leu Lys Ser Val Val Gly His             340 345 350 Ala Gln Ala Ala Ala Gly Val Ala Gly Leu Ile Ala Thr Val Gln Ala         355 360 365 Leu Arg His Glu Leu Leu Pro Ala Thr Arg His Ala Val Thr Pro Ser     370 375 380 Thr Arg Val Asp Trp Ser Ala Gly Ala Val Ala Leu Arg Thr Ala Pro 385 390 395 400 Val Pro Trp Pro Arg Gly Gly Arg Pro Arg Arg Ala Gly Val Ser Ser                 405 410 415 Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Val Glu Glu Ala Pro             420 425 430 Ala Ala Asp Gly Pro Glu Ala Ala Asp Arg Gly Thr Ala Pro Pro Ala         435 440 445 Val Thr Pro Trp Pro Val Ser Ala Ala Ala Ala Arg Asp Leu Asp Ala     450 455 460 Gln Ile Glu Arg Leu Arg Ala His Thr Ala Gly Pro Gly Ala Pro Asp 465 470 475 480 Pro Arg Asp Val Gly Trp Ser Leu Ala Thr Gly Arg Ala Ala Leu Arg                 485 490 495 His Arg Ala Val Leu Leu Leu Gly Glu His Gly Pro Val Glu Val Ala             500 505 510 Arg Glu Gln Ala Ala Pro Arg Arg Ala Ala Val Leu Phe Ser Gly Gln         515 520 525 Gly Ser Gln Arg Leu Gly Thr Gly Arg Ala Leu Ala Ala Arg Phe Pro     530 535 540 Val Phe Ala Arg Ala Phe Asp Asp Val Thr Ala Ala Leu Asp Ala His 545 550 555 560 Leu Asp Arg Pro Val Arg Asp Val Ala Trp Gly Thr Gly Asp Asp Ala                 565 570 575 Ala Ala Leu Leu Asp Glu Thr Gly Trp Thr Gln Pro Ala Leu Phe Ala             580 585 590 Val Glu Val Ala Leu Phe Arg Leu Val Thr Ala Leu Gly Leu Arg Pro         595 600 605 Ala Ala Val Gly Gly His Ser Ile Gly Glu Ile Thr Ala Ala His Val     610 615 620 Ala Gly Val Leu Ser Leu Asp Asp Ala Ala Arg Leu Val Ala Ala Arg 625 630 635 640 Ala Thr Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val Ala Val                 645 650 655 Glu Ala Ser Glu Asp Glu Val Ala Pro Leu Leu Gly Asp Arg Val Ala             660 665 670 Leu Ala Ala Val Asn Gly Pro Ala Ser Val Val Val Ala Gly Asp Asp         675 680 685 Asp Ala Val Thr Ala Leu Ala Ala Glu Leu Ala Asp Arg Gly Arg Arg     690 695 700 Thr Ser Arg Leu Ala Val Ser His Ala Phe His Ser Pro Arg Met Glu 705 710 715 720 Pro Met Leu Glu Glu Phe Arg Gly Val Val Ala Gly Leu Thr Phe Cys                 725 730 735 Glu Pro Arg Ile Pro Leu Val Ser Asn Leu Thr Gly Glu Leu Gly Pro             740 745 750 Thr Ala Ala Thr Asp Pro Gly Tyr Trp Val Arg His Val Arg Gly Thr         755 760 765 Val Arg Phe Ala Asp Gly Val Arg Ser Leu Ala Ala Asp Gly Val Asp     770 775 780 Val Phe Val Glu Leu Gly Pro Gly Gly Val Leu Ser Ala Met Ala Arg 785 790 795 800 Glu Thr Leu Gly Pro Asp Thr Ala Ala His Val Val Pro Val Leu Arg                 805 810 815 Arg Asp Arg Pro Glu Glu Thr Ser Phe Ala Val Ala Leu Gly Arg Leu             820 825 830 His Ala Leu Gly Val Pro Met Asp Trp His Ala Phe His Ala Gly Thr         835 840 845 Gly Ala Arg Arg Val Pro Leu Pro Thr Tyr Ala Phe Arg Gly Val Arg     850 855 860 Tyr Trp Pro Ala Pro Pro Thr Pro Gly Asn Pro Gly Gly Ser Pro Gly 865 870 875 880 Leu Phe Pro Ala Ser Gly Ala Arg Thr Ala Thr Glu Pro Gly Pro Asp                 885 890 895 Ala Arg Val Val Thr Asn Pro Ala Ser Ala Thr Ala Arg Pro Asp Pro             900 905 910 Val Pro Thr Gly Thr Ala Ala Gly Asp Pro Gly Glu Asp Arg Ala Gly         915 920 925 Thr Asp Pro Gly Ala Arg Tyr Ala Val Met Pro Pro Ala Val Arg Glu     930 935 940 Arg Ala Leu Leu Asp Leu Val Arg Thr His Thr Ala Ala Val Leu Gly 945 950 955 960 His Pro Asp Pro Ala Glu Ile Gly Val Arg Ser Val Phe Lys Glu Leu                 965 970 975 Gly Leu Asp Ser Leu Ala Gly Val Glu Leu Cys Asp Arg Leu Ala Arg             980 985 990 Asp Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Gly Phe Pro Thr         995 1000 1005 Pro Glu Leu Ala Ala Arg Glu Val Ser Ala Leu Leu Gly Pro Gly     1010 1015 1020 Pro Gln Glu Pro Cys Gly Pro Glu Leu Ala Gly Leu Glu Ala Ala     1025 1030 1035 Leu Asp Gly Leu Ser Gly Asp Gly Pro Asp Arg Arg Ala Val Ala     1040 1045 1050 Asp Arg Leu Glu Val Leu Ala Aly Gly Leu Arg Arg Pro Ala Ala     1055 1060 1065 Gln Pro Gly Gly Pro Pro Asp Glu Asp Leu Asp Ser Val Ser Val     1070 1075 1080 Asp Arg Leu Leu Asp Ile Ile Asp Glu Glu Phe Asp Thr Ala     1085 1090 1095 <210> 14 <211> 3175 <212> PRT <213> Pseudonocardia autotrophica <400> 14 Met Gln Glu Ser Gln Asp Gln Gln Asn Arg Ile Val Asp Ser Leu Arg 1 5 10 15 Arg Val Thr Thr Asp Leu Arg Arg Ala Arg Arg Arg Ile Asp Glu Leu             20 25 30 Glu Ser Val Gly Asn Glu Pro Val Ala Ile Val Gly Met Gly Cys Arg         35 40 45 Leu Pro Gly Gly Val Asp Ser Pro Glu Ser Leu Trp Asp Leu Val Ser     50 55 60 Ala Gly Gly Asp Gly Ile Ala Glu Phe Pro Ala Asp Arg Gly Trp Asp 65 70 75 80 Leu Asp Ala Leu Arg Ser Thr Gly Asp Gly Gly Ser Ala Thr Ala Arg                 85 90 95 Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly             100 105 110 Ile Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu         115 120 125 Leu Glu Val Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Asp Pro Thr     130 135 140 Ser Leu Arg Gly Ser Arg Ala Gly Val Phe Val Gly Ser Tyr His Trp 145 150 155 160 Gly Ser Pro Ser Ala Asp Ala Gly Thr Glu Leu Gly Gly His Ala Leu                 165 170 175 Thr Gly Thr Ala Ala Ser Val Leu Ser Gly Arg Leu Ser Tyr Thr Leu             180 185 190 Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser         195 200 205 Leu Val Ala Leu His Leu Ala Ala His Ser Leu Arg Ser Gly Glu Ser     210 215 220 Ser Leu Ala Val Val Gly Gly Val Thr Ile Leu Ala Asp Pro Ser Val 225 230 235 240 Phe Val Glu Phe Ser Ala Gln Gly Gly Leu Ser Val Asp Gly Arg Cys                 245 250 255 Lys Ala Phe Ser Asp Asp Ala Asp Gly Thr Gly Trp Ala Glu Gly Val             260 265 270 Gly Val Leu Val Ala Glu Arg Leu Ser Asp Ala Arg Ala Asn Gly His         275 280 285 Arg Val Leu Ala Val Leu Arg Gly Ser Ala Val Asn Gln Asp Gly Ala     290 295 300 Ser Asn Gly Leu Thr Ala Pro His Gly Pro Ser Gln Glu Arg Val Ile 305 310 315 320 Thr Gln Ala Leu Glu Arg Ala Ala Leu Thr Ala Ala Asp Val Asp Ala                 325 330 335 Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala             340 345 350 Gln Ala Leu Leu Ala Thr Tyr Gly Arg Gly Arg Asp Thr Asp Arg Pro         355 360 365 Leu Tyr Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala     370 375 380 Ala Gly Val Ala Gly Val Ile Lys Met Val Gln Ala Leu Arg His Arg 385 390 395 400 Val Leu Pro Pro Thr Leu His Ala Gly Thr Pro Ser Ser His Val Asp                 405 410 415 Trp Ser Ala Gly Thr Val Arg Leu Leu Thr Glu Arg Thr Ala Trp Pro             420 425 430 Glu Thr Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser         435 440 445 Gly Thr Asn Ala His Ala Val Leu Glu Gln Ala Pro Ala Ala Gln Glu     450 455 460 Glu Pro Ala Pro Gly Gly Gly Pro Thr Gly Val Leu Ala Trp Val Leu 465 470 475 480 Ser Gly His Thr Val Gln Ala Arg Arg Asp Arg Ala Ala Thr Leu His                 485 490 495 Ala Arg Leu Arg Glu Asp Gly Thr Ala Asp Pro His Asp Val Gly His             500 505 510 Ala Leu Leu Thr Thr Arg Ala Arg His Glu His Arg Ala Val Val Val         515 520 525 Gly Thr Ala Arg Asp Glu Leu Leu Asp Gly Val Gly Ala Leu Ala Ala     530 535 540 Gly Thr Pro Ala Pro His Val Ala His Gly Val Ala Asp Val Glu Gly 545 550 555 560 Arg Thr Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ile Gly Met                 565 570 575 Gly Ala Arg Leu Leu Glu Glu Ser Pro Val Phe Ala Ala Arg Met Ala             580 585 590 Glu Cys Ala Ala Ala Leu Asp Pro Ile Thr Gly Trp Ser Leu His Asp         595 600 605 Val Leu Arg Arg Ala Glu Gly Ala Pro Asp Ala Asp Arg Val Asp Val     610 615 620 Val Gln Pro Ala Ser Phe Ala Val Met Val Ala Leu Ala Ala Leu Trp 625 630 635 640 Arg Ala His Gly Val Glu Pro Asp Ala Val Val Gly His Ser Gln Gly                 645 650 655 Glu Ile Ala Ala Ala Val Val Ser Gly Ala Leu Ser Leu Pro Asp Gly             660 665 670 Ala Gly Val Val Ala Leu Arg Ser Arg Ala Ile Gly Arg Ser Leu Ala         675 680 685 Gly Arg Gly Gly Met Met Ser Val Ala Leu Pro Val Asp Glu Val Ser     690 695 700 Gly Arg Leu Glu Glu Tyr Ala Gly Arg Val Ser Val Ala Ala Val Asn 705 710 715 720 Gly Pro Arg Ser Val Val Val Ser Gly Glu Pro Gln Ala Leu Asp Glu                 725 730 735 Leu Gly Ala Val Leu Asp Gly Glu Gly Ile Arg Val Arg Arg Val Ala             740 745 750 Val Asp Tyr Ala Ser His Ser His Gln Val Glu Glu Leu Arg Ala Glu         755 760 765 Ile Leu Glu Thr Leu Ala Gly Leu Ser Pro Gln Pro Ser Ala Val Pro     770 775 780 Leu Tyr Ser Thr Leu Thr Gly Gly Leu Leu Asp Thr Ser Thr Met Asp 785 790 795 800 Ala Ala Tyr Trp Tyr Glu Asn Leu Arg Asn Arg Val Arg Phe Ala Asp                 805 810 815 Ala Val Ala Ala Leu Thr Ala Thr Gly His Arg Val Phe Val Glu Ser             820 825 830 Ala Ala His Pro Val Leu Ser Pro Ala Val Gln Asp Ala Leu Asp Asp         835 840 845 Ala Gly Ile Thr Gly Val Ala Gly Gly Thr Leu Arg Arg Asp Gln Gly     850 855 860 Gly Tyr Asp Arg Phe Leu Leu Ser Ala Ala Gln Leu His Val Arg Gly 865 870 875 880 Leu Asp Val Asp Trp Ser Val Leu Phe Asp Asp Ala Ala Ala Ala Arg                 885 890 895 Val Asp Leu Pro Thr Tyr Pro Phe Gln His Glu Arg Tyr Trp Ser Thr             900 905 910 Arg Thr Ala Thr Ala Ala Ala Pro Asp Thr Gly Ala Leu Asp Thr Glu         915 920 925 Phe Trp Asp Ala Val Glu Gln Ala Asp Leu Pro Ala Leu Thr Ala Ala     930 935 940 Leu Gly Thr Asp Glu Asp Ala Val Thr Ala Ile Leu Pro Gly Leu Ser 945 950 955 960 Ala Trp Arg Arg Ser Arg Ala Asp Arg Ala Asp Leu Asp Thr Trp Arg                 965 970 975 Tyr Arg Val Glu Trp Ala Ala Thr Pro Gln Pro Pro Arg Thr Gly Pro             980 985 990 Thr Gly Thr Trp Leu Val Val Ala Ala Gly Thr Asp Pro Ala Asp         995 1000 1005 Val Val Gly Val Leu Glu Arg His Gly Ala Val Ala Leu Pro Leu     1010 1015 1020 Val Leu Asp Glu Ser Thr Asp Arg Asp Asp Thr Asp Arg Glu Val     1025 1030 1035 Leu Arg Ala Arg Ile Ala Asp Ala Thr Ala Asp Gly Asp Ile Ala     1040 1045 1050 Gly Val Val Ser Leu Leu Ala Ala Ala Glu Asp Asp Asp Pro Arg     1055 1060 1065 His Pro Gly Leu Thr Arg Gly Leu Ala Leu Ser Val Ala Leu Val     1070 1075 1080 Gln Ala Leu Gly Asp Ala Gly Ile Asp Val Ala Leu Trp His Leu     1085 1090 1095 Thr Arg Gly Ala Ala Thr Ala Ala Pro Gly Asp Thr Val Thr Arg     1100 1105 1110 Pro Leu Gln Ser Gln Val Ala Ala Leu Gly Trp Thr Ala Ala Val     1115 1120 1125 Glu Gln Pro His Arg Arg Gly Gly Thr Ala Asp Leu Pro Glu Val     1130 1135 1140 Leu Asp Ala Arg Thr Gly Asp Arg Leu Ala Ala Val Leu Ala Gly     1145 1150 1155 Arg Leu Gly Asp Glu Asp Gln Leu Ala Val Arg Pro Ala Gly Val     1160 1165 1170 Leu Ala Arg Arg Ile Val Arg Ala Asp Arg Gly Gly Arg Ala Pro     1175 1180 1185 Ala Arg Arg Trp Ser Pro Arg Gly Thr Thr Leu Val Thr Gly Gly     1190 1195 1200 Ser Gly Thr Leu Ala Pro Asp Leu Ala Arg Arg Leu Ala Ala Asp     1205 1210 1215 Gly Ala Glu His Val Val Leu Leu Ser Arg Arg Gly Pro Glu Ala     1220 1225 1230 Pro Gly Ala Ala Ala Leu Val Ala Glu Leu Ala Glu Ala Gly Thr     1235 1240 1245 Glu Ala Glu Ala Val Ala Cys Asp Ile Thr Asp Arg Asp Ala Val     1250 1255 1260 Ala Ala Leu Val Ala Arg Leu Ala Ala Gln Gly Arg Thr Val Gly     1265 1270 1275 Thr Val Leu His Thr Ala Ala Val Ile Gly Leu Ala Ala Ile Ala     1280 1285 1290 Asp Thr Thr Leu Asp Glu Phe Ala Glu Val Val His Ala Lys Val     1295 1300 1305 Thr Gly Ala Arg Ile Leu Asp Glu Leu Leu Asp Asp Pro Ala Thr     1310 1315 1320 Asp Leu Val Leu Tyr Ser Ser Thr Ala Gly Met Trp Gly Ser Gly     1325 1330 1335 Val His Ala Ala Tyr Ala Ala Gly Asn Ala Phe Leu Ser Ala Leu     1340 1345 1350 Ala Glu Gln Arg Arg Ala Arg Gly Leu Arg Ala Thr Ser Val His     1355 1360 1365 Trp Gly Lys Trp Pro Asp Ala Asp Pro Glu Arg Thr Glu Ala Asp     1370 1375 1380 Pro His Arg Ile Arg Arg Ser Gly Leu Glu Tyr Leu Asp Pro Gln     1385 1390 1395 Arg Ala Leu Thr Gly Leu Arg Cys Val Leu Asp Asp Asp Glu Thr     1400 1405 1410 Val Val Gly Leu Met Asp Val Asp Trp Asp Val Tyr His Asp Val     1415 1420 1425 Phe Thr Ala Gly Arg Val Ser His Leu Phe Asp Arg Val Pro Glu     1430 1435 1440 Val Arg Ala Arg Leu Thr His Ala Ala Ala Pro Ala Ala Gly Pro     1445 1450 1455 Arg Gly Ala Leu Ala Gly Arg Leu Ala Pro Leu Ser Ala Ala Glu     1460 1465 1470 Arg Thr Arg Leu Leu Val Thr Leu Val Arg Thr Glu Ala Ala Ala     1475 1480 1485 Val Leu Gly His Ala Ser Ala Asp Ala Phe Gly Glu Arg Arg Ala     1490 1495 1500 Phe Arg Asp Ala Gly Phe Asp Ser Val Thr Ala Val Asp Leu Arg     1505 1510 1515 Asn Arg Leu Ala Ala Ala Thr Gly Leu Thr Leu Pro Ser Thr Leu     1520 1525 1530 Val Phe Asp His Pro Ser Pro Ala Val Leu Ala Gly Arg Leu Glu     1535 1540 1545 Glu Leu Ala Leu Gly Ala Ala Asp Gly Leu Pro Gln Pro Ala Ala     1550 1555 1560 Ala Pro Ala Gly Asp Asp Asp Pro Ile Ala Val Ile Gly Met Ser     1565 1570 1575 Cys Arg Tyr Pro Gly Gly Ala Asp Thr Pro Glu Ala Leu Leu Gln     1580 1585 1590 Leu Ala Leu Asp Gly Val Asp Ala Ile Thr Gly Phe Pro Thr Gly     1595 1600 1605 Arg Gly Trp Asp Ala Ala Ala Leu His Asp Pro Asp Pro Asp Arg     1610 1615 1620 His Gly Arg Thr Tyr Ser Val Gln Gly Gly Phe Leu His Asp Val     1625 1630 1635 Ala Asp Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala     1640 1645 1650 Val Ala Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Thr Ser Trp     1655 1660 1665 Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Thr Ser Leu Arg Gly     1670 1675 1680 Thr Ser Thr Gly Thr Phe Val Gly Ala Thr Tyr Gln Asp Tyr Ala     1685 1690 1695 Thr Thr Val Ala His Ala Ala Gly Asp Thr Glu Thr His Met Val     1700 1705 1710 Thr Gly Thr Ala Ala Ser Val Leu Ser Gly Arg Val Ala Tyr Leu     1715 1720 1725 Leu Gly Leu Glu Gly Pro Ala Val Thr Leu Asp Thr Ala Cys Ser     1730 1735 1740 Ser Ser Leu Val Ala Met His Leu Ala Cys Arg Ser Leu Arg Ser     1745 1750 1755 Gly Glu Ser Ser Leu Ala Leu Ala Gly Gly Ala Ala Val Met Ala     1760 1765 1770 Thr Pro Gln Ala Phe Val Gly Phe Ser Arg Gln Arg Ala Leu Ala     1775 1780 1785 Ala Asp Gly Arg Cys Lys Pro Phe Ser Glu Ala Ala Asp Gly Met     1790 1795 1800 Thr Leu Ala Glu Gly Val Gly Val Val Leu Leu Glu Arg Leu Ser     1805 1810 1815 Asp Ala Arg Arg Lys Gly His Pro Val Leu Gly Val Ile Arg Gly     1820 1825 1830 Ser Ala Ile Asn Ser Asp Gly Ala Ser Asn Gly Met Thr Ala Pro     1835 1840 1845 Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Arg Ala Leu Ala Glu     1850 1855 1860 Ala Gly Leu Thr Ala Ala Asp Val Asp Val Val Glu Ala His Gly     1865 1870 1875 Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu     1880 1885 1890 Ala Thr Tyr Gly Arg Asp Arg Asp Glu Pro Leu Arg Leu Gly Ser     1895 1900 1905 Val Lys Ser Ala Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala     1910 1915 1920 Gly Val Ile Thr Met Leu Ala Ala Met Arg Ala Gly Glu Leu Pro     1925 1930 1935 Gly Ile Gln His Leu Asp Ala Pro Ser Ser His Val Asp Trp Ser     1940 1945 1950 Thr Gly Ala Val Glu Leu Leu Thr Gly Arg Thr Ala Trp Pro Glu     1955 1960 1965 Thr Asp Arg Pro Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser     1970 1975 1980 Gly Thr Asn Ala His Val Val Leu Glu Gln Ala Pro Pro Ala Glu     1985 1990 1995 Ala Thr Pro Pro Ala Gly Ala Pro Gly Pro Val Pro Trp Val Val     2000 2005 2010 Ser Ala Arg Ser Ala Asp Ala Leu Arg Ala Gln Ala Gly Arg Leu     2015 2020 2025 Arg Asp Ala Val Ala Arg Asp Pro Gln Asp Pro Ala Arg Thr Gly     2030 2035 2040 His Ala Leu Ala Thr Thr Arg Ala Ala Phe Asp His Arg Ala Val     2045 2050 2055 Val Val Gly Glu Thr Ser Asp Glu Leu Ser Arg Gly Leu Ala Ala     2060 2065 2070 Leu Ala Asp Gly Thr Ser Val Ala Gly Leu Val Thr Gly Thr Ala     2075 2080 2085 Ala Glu Asp Pro Ala Gly Pro Val Phe Val Phe Pro Gly Gln Gly     2090 2095 2100 Ala Gln Trp Trp Gly Met Gly Arg Asp Leu Leu Thr Thr Ser Glu     2105 2110 2115 Ala Phe Arg Ala Ala Val Asp Asp Cys Ala Ala Ala Leu Ala Pro     2120 2125 2130 His Val Asp Trp Ser Leu His Glu Val Leu Thr Gly Asp Gly Asp     2135 2140 2145 Pro Ala Leu Leu Glu Arg Val Asp Val Val Gln Pro Ala Leu Phe     2150 2155 2160 Ala Met Met Val Gly Leu Ala Ala Val Trp Arg Ala His Gly Val     2165 2170 2175 Glu Pro Ala Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala     2180 2185 2190 Ala His Val Ala Gly Ala Leu Asp Leu Asp Asp Ala Ala Arg Val     2195 2200 2205 Val Ala Leu Arg Ser Arg Ala Leu Pro Arg Leu Ser Gly His Gly     2210 2215 2220 Gly Met Val Ser Val Ala Ala Pro Val Gly Arg Val Thr Glu Leu     2225 2230 2235 Ile Val Pro Trp Gly Gly Ala Leu Ser Val Ala Ala Val Asn Gly     2240 2245 2250 Pro Ser Ser Val Val Val Gly Asp Ala Asp Ala Leu Asp Ala     2255 2260 2265 Leu Leu Pro Ala Cys Glu Ser Ala Gly Val Arg Ala Arg Arg Val     2270 2275 2280 Ser Val Asp Tyr Ala Ser His Gly Pro His Val Glu Ala Val Arg     2285 2290 2295 Asp Glu Leu Ala Glu Val Leu Ala Gly Ile Thr Pro Arg Thr Pro     2300 2305 2310 Thr Val Pro Phe Tyr Ser Thr Val Thr Gly Gly Arg Leu Asp Thr     2315 2320 2325 Ala Glu Asp Gly Gly Leu Asp Gly Thr Tyr Trp Tyr Thr Asn Leu     2330 2335 2340 Arg Thr Thr Val Arg Met Gln Asp Ala Thr Glu Ala Leu Leu Ala     2345 2350 2355 Ala Gly His Arg Ile Phe Val Glu Val Ser Pro His Pro Val Leu     2360 2365 2370 Ala Gly Pro Val Gln Glu Thr Gln Glu Ala Ala Asp Pro Asp Gly     2375 2380 2385 Thr Ala Ala Ala Val Val Leu Gly Thr Leu Arg Arg Asp Glu Gly     2390 2395 2400 Gly Pro Ala Arg Val Leu Thr Ser Leu Ala Glu Ala Tyr Val His     2405 2410 2415 Gly Ala Thr Val Asp Trp Thr Thr Thr Leu Pro Asp Thr Gly Gly     2420 2425 2430 Thr Asp Val Glu Leu Pro Thr Tyr Ala Phe Arg Arg Arg Ser Tyr     2435 2440 2445 Trp Pro Glu Pro Lys Ala Asp Pro Ser Gly Ala Ala Asp Asp Ala     2450 2455 2460 Ala Phe Trp Ala Leu Val Asp Gly Gln Asp Pro Ala Ala Phe Ala     2465 2470 2475 Asp Ala Leu Gly Val Pro Gly Gly Ala Leu Asp Thr Val Leu Pro     2480 2485 2490 Ala Leu Ser Ala Trp Arg Ala Gly Ser Arg Ala Arg Thr Arg Ala     2495 2500 2505 Asn Asp Leu Arg Tyr Arg Val Asp Trp Ala Pro Val Pro Glu Pro     2510 2515 2520 Ala Ala Gly Pro Pro Ala Gly Arg Val Leu Val Ile Gly His Asp     2525 2530 2535 Ala Gly Thr Gly Thr Asp Asp Asp Gly Leu Leu Ala Ala Phe Gly     2540 2545 2550 Pro Gly Ala Val Pro Val Thr Asp Pro Gly Thr Gly Arg Ala Ala     2555 2560 2565 Trp Ala Ala Glu Leu Ala Arg His Ala Ala Asp Gly Pro Val Thr     2570 2575 2580 Ala Val Val Ala Leu Pro Asp Pro Thr Gly Arg Pro His Pro Gly     2585 2590 2595 His Pro Gly Val Pro Gly Ala Leu Ala Arg Thr Leu Thr Leu Val     2600 2605 2610 Gln Ala Leu Gly Asp Ala Asp Val Thr Ala Pro Leu Trp Cys Leu     2615 2620 2625 Thr Arg Gly Ala Val Gly Thr Ala Pro Gly Asp Ala Val Thr Asp     2630 2635 2640 Pro Glu Gln Gly Thr Leu Trp Gly Leu Gly Arg Val Val Ala Leu     2645 2650 2655 Glu His Pro Asp Arg Trp Gly Gly Leu Ile Asp Leu Pro Gly Thr     2660 2665 2670 Pro Asp Pro Arg Thr Ala Ala Arg Val Ala Gly Leu Val Thr Gly     2675 2680 2685 Ala Gly Thr Glu Asp Gln Leu Ala Val Arg Pro His Gly Val Leu     2690 2695 2700 Ala Arg Arg Leu Val His Ala Ala Pro Ala Ala Pro Arg Pro Gly     2705 2710 2715 His Gly Gly Cys Asp Arg Gly Thr Val Leu Val Thr Gly Gly Thr     2720 2725 2730 Gly Gly Ile Gly Gly Arg Thr Ala Val Trp Ala Ala Gly Arg Gly     2735 2740 2745 Ala Glu His Leu Leu Leu Thr Ser Arg Arg Gly Glu Asp Ala Pro     2750 2755 2760 Gly Ala Ala Ala Leu Arg Thr Glu Leu Glu Ser Leu Gly Ala Arg     2765 2770 2775 Val Thr Ile Ala Ala Cys Asp Ala Ala Asp Arg Asp Ala Leu Ala     2780 2785 2790 Thr Leu Leu Asp Glu Leu Pro Ala Asp Leu Pro Leu Thr Ala Val     2795 2800 2805 Val His Ser Ala Gly Val Ala Asp Gly Asp Ala Pro Val Ala Asp     2810 2815 2820 Leu Thr Val Asp Arg Leu Asp Ala Leu Leu Arg Ala Lys Leu Thr     2825 2830 2835 Ala Ala Arg Asn Leu His Glu Leu Thr Arg Gly Thr Glu Leu Asp     2840 2845 2850 Ala Phe Val Leu Tyr Ser Ser Gly Ala Ala Val Trp Gly Ser Gly     2855 2860 2865 Gly Gln Pro Gly Tyr Ala Ala Ala Asn Ala Tyr Leu Asp Ala Leu     2870 2875 2880 Ala Ala His Arg Arg Gly Leu Gly Leu Pro Ala Thr Ser Val Ala     2885 2890 2895 Trp Gly Thr Phe Gly Glu Val Gly Met Ala Thr Asp Pro Gln Val     2900 2905 2910 His Glu Arg Leu His Arg Gln Gly Val Pro Ala Met Asp Pro Ala     2915 2920 2925 Asp Ala Leu Ala Ala Leu Glu Leu Ala Leu Gly Glu Gly Asp Thr     2930 2935 2940 Gly Val Ala Val Thr Arg Met Asp Trp Glu Val Phe Ala Pro Ser     2945 2950 2955 Phe Thr Ala Leu Arg Pro Ser Pro Leu Leu Gly Thr Val Pro Glu     2960 2965 2970 Ala Val Ala Ala Leu Ala Asp Gly Pro Ala Pro Val Pro Gly Asp     2975 2980 2985 Pro Gly Ala Asp Ala Ala Val Pro Pro Leu Arg Gly Arg Leu Glu     2990 2995 3000 Ala Leu Pro Thr Ala Glu Arg Ala Arg Ala Leu Val Glu Ala Val     3005 3010 3015 Arg Gly Glu Ala Ala Ala Thr Leu Gly His Asp Gly Ala Asp Ala     3020 3025 3030 Ile Pro Ala Gly Arg Ala Phe Arg Asp Val Gly Phe Asp Ser Val     3035 3040 3045 Thr Ala Val Glu Leu Arg Asn Arg Leu Arg Gly Gly Leu Gly Leu     3050 3055 3060 Pro Leu Pro Ala Ala Leu Val Phe Asp His Pro Thr Pro Thr Asp     3065 3070 3075 Leu Ala Arg His Leu Gly Thr Leu Leu Phe Gly Asp Thr Pro Gly     3080 3085 3090 Glu Gln Gly Thr Thr Arg Thr Asp Asp Pro Asp Ala His Ile Arg     3095 3100 3105 Glu Val Leu Ala Ser Val Pro Ile Gly Arg Leu Arg Arg Ala Gly     3110 3115 3120 Leu Leu Asp Met Val Leu Gly Leu Ala Asp Ala Glu Pro Gly Ala     3125 3130 3135 Ala Asp Asp Pro Asp Pro Asp Ala Gly Arg Thr Asp Asp Gly Gly     3140 3145 3150 Ala Glu Ser Leu Asp Asp Met Asp Ala Glu Ala Leu Leu Arg Leu     3155 3160 3165 Val Thr Glu Asn Ser Ala Asn     3170 3175 <210> 15 <211> 10876 <212> PRT <213> Pseudonocardia autotrophica <400> 15 Met Ser Thr Ser Asp Gln Lys Tyr Val Glu Ala Leu Arg Ser Ser Leu 1 5 10 15 Lys Glu Val Glu Arg Leu Arg Arg Gln Asn Glu Gln Leu Val Ala Ala             20 25 30 Ala Ser Glu Pro Val Ala Val Val Gly Ile Gly Cys Arg Phe Pro Gly         35 40 45 Gly Val Ala Ser Pro Glu Asp Leu Trp Asp Val Val Ala His Gly Arg     50 55 60 Asp Val Leu Gly Pro Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Ala 65 70 75 80 Leu Ala Gly Asp Gly Glu Gly Gly Ser Leu Ala Gln Val Gly Gly Phe                 85 90 95 Val Asp Asp Val Ala Gly Phe Asp Pro Gly Phe Phe Gly Ile Ser Pro             100 105 110 Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Ile         115 120 125 Thr Trp Glu Ala Leu Glu Arg Ala Gly Ile Asp Pro Thr Ser Leu Arg     130 135 140 Gly Thr Asp Thr Gly Val Phe Val Gly Thr Thr Gly Gln Asp Tyr Gly 145 150 155 160 Glu Val Ile Arg Ala Ser Asp Glu Asp Val Ala Val Tyr Ser Thr Thr                 165 170 175 Gly His Ala Ala Ser Val Ile Ser Gly Arg Leu Ser Tyr Thr Leu Gly             180 185 190 Ala Glu Gly Pro Ala Val Thr Val Asp Thr Gly Cys Ser Ser Ser Leu         195 200 205 Val Ala Met His Gln Ala Val Gln Ala Leu Arg Ala Gly Glu Cys Ser     210 215 220 Thr Ala Leu Ala Gly Gly Ala Ser Val Met Ala Thr Pro Gly Pro Phe 225 230 235 240 Val Ala Phe Thr Ala Gln Ser Gly Leu Ala Ala Asp Gly Arg Cys Lys                 245 250 255 Pro Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp Ala Glu Gly Ala Gly             260 265 270 Met Leu Val Leu Met Arg Leu Ser Asp Ala Arg Arg Gln Gly Arg Glu         275 280 285 Val Leu Ala Val Leu Arg Gly Ser Ala Ile Asn Gln Asp Gly Ala Ser     290 295 300 Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg 305 310 315 320 Ala Ala Leu Glu Ser Ala Arg Leu Gly Ser Gly Asp Val Asp Ala Val                 325 330 335 Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln             340 345 350 Ala Leu Leu Ala Thr Tyr Gly Ala Asp Arg Ala Thr Pro Leu Leu Leu         355 360 365 Gly Ser Val Lys Ser Asn Met Gly His Thr Gln Ala Ala Ser Gly Val     370 375 380 Ala Gly Val Ile Lys Met Ile Met Ala Leu Arg His Gly Val Leu Pro 385 390 395 400 Arg Ser Leu His Ala Glu Arg Pro Ser Ala Asp Val Asp Trp Thr Ala                 405 410 415 Gly Ala Val Ala Leu Leu Asp Ala Ala Val Asp Trp Pro Glu Thr Gly             420 425 430 Arg Pro Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn         435 440 445 Ala His Val Ile Leu Glu Gln Ala Pro His Thr Asp Ala Gln Ala Pro     450 455 460 Ala Ala Glu Val Ser Ala Pro Ala Val Val Pro Trp Pro Leu Ser Ala 465 470 475 480 Arg Thr Ala Thr Ala Leu Asp Thr Leu Arg Ala Arg Leu Thr Gly Ser                 485 490 495 Val Thr Gly Leu Ser Pro Leu Asp Val Gly Ala Ser Leu Ala Thr Gly             500 505 510 Arg Ala Thr Phe Glu His Arg Ala Val Leu Leu Gly Ser Gly Asp Glu         515 520 525 Val Thr Glu Ile Ala Arg Gly Val Ala Gly Glu Gly Leu Thr Ala Leu     530 535 540 Leu Phe Ser Gly Gln Gly Ser Gln Arg Leu Gly Ala Gly Arg Glu Leu 545 550 555 560 His Ala Arg Phe Pro Val Phe Ala Glu Ala Phe Asp Glu Thr Ala Ala                 565 570 575 Leu Leu Asp Ala Ala Leu Pro Asp Asn Asp Ala Thr Leu Arg Glu Val             580 585 590 Leu Trp Gly Thr Asp Ala Glu Ala Leu Asp Asp Thr Gly Arg Ala Gln         595 600 605 Pro Ala Leu Phe Ala Ile Glu Val Ala Leu Tyr Arg Leu Val Thr Ser     610 615 620 Leu Gly Val Val Pro Asp Leu Val Gly Gly His Ser Ile Gly Glu Ile 625 630 635 640 Ala Ala Ala His Val Ala Gly Val Leu Ser Leu Asp Asp Ala Ala Thr                 645 650 655 Leu Val Ala Ala Arg Ala Arg Leu Met Ala Ala Leu Pro Arg Gly Gly             660 665 670 Ala Met Leu Ala Val Gly Ala Thr Glu Asp Glu Val Ala Pro Leu Leu         675 680 685 Thr Ala Gly Val Ser Leu Ala Ala Val Asn Gly Pro Ser Ser Val Val     690 695 700 Val Ala Gly Asp Thr Asp Gly Ile Ala Ala Val Glu Glu His Ala Arg 705 710 715 720 Ala Arg Gly Trp Arg Ser Thr Arg Leu Arg Val Ser His Ala Phe His                 725 730 735 Ser Pro Leu Met Glu Pro Met Leu Ala Glu Phe Arg Ala Val Ala Ala             740 745 750 Gly Leu Thr Tyr His Glu Pro Arg Ile Pro Val Val Ser Asn Leu Thr         755 760 765 Gly Ser Val Ala Glu Val Ala Asp Ile Cys Ser Ala Asp Tyr Trp Val     770 775 780 Arg His Val Arg Gly Thr Val Arg Phe Ala Asp Gly Val Thr Ala Leu 785 790 795 800 Ala Ala Arg Gly Val Thr Thr Leu Val Glu Leu Gly Pro Asp Gly Val                 805 810 815 Leu Cys Gly Met Ala Gln Glu Ser Leu Pro Glu Gly Ala Val Ala Val             820 825 830 Pro Leu Leu Arg Arg Asp Arg Pro Glu Glu Leu Ser Leu Val Thr Gly         835 840 845 Leu Ala Thr Ala His Val Arg Gly Thr Thr Val Asp Trp Ala Arg Leu     850 855 860 Phe Asp Gly Thr Gly Ala Ser Arg Val Asp Leu Pro Thr Tyr Pro Phe 865 870 875 880 Glu His Thr Arg Tyr Trp Pro Ala Pro Val Arg Gly Ala Ala Asp Val                 885 890 895 Thr Ala Ala Gly Leu Thr Thr Ala Asp His Pro Leu Leu Gly Ala Ala             900 905 910 Val Glu Leu Ala Gly Asp Asp Gly Val Leu Phe Thr Ser Arg Leu Ser         915 920 925 Val Arg Thr His Pro Trp Leu Ala Asp His Gly Val Gln Gly Arg Ala     930 935 940 Leu Leu Pro Gly Thr Ala Phe Val Glu Leu Ala Val Arg Ala Gly Asp 945 950 955 960 Glu Val Gly Cys Thr Arg Val Glu Glu Leu Thr Leu Ala Ala Pro Leu                 965 970 975 Val Leu Pro Glu Arg Gly Gly Val Arg Val Gln Val Arg Val Gly Pro             980 985 990 Ala Asp Ala Arg Gly Arg Arg Thr Leu Gly Val Phe Ser Arg Pro Glu         995 1000 1005 Asp Ala Asp Gly Leu Pro Trp Ser Gln His Ala Thr Gly Val Leu     1010 1015 1020 Gly Ser Gly Thr Thr Ala Pro Asp Gly Leu Asp Thr Thr Ala Trp     1025 1030 1035 Pro Pro Ala Gly Ala Glu Pro Val Asp Leu Glu Gly Cys Tyr Glu     1040 1045 1050 Arg Leu Ala Gly Ile Gly Phe Asp Tyr Gly Pro Ser Phe Arg Gly     1055 1060 1065 Leu His Ala Ala Trp Arg Arg Asp Gly Glu Val Phe Ala Glu Val     1070 1075 1080 Thr Leu Pro Asp Gly Ala Gly Thr Asp Thr Thr Gly Phe Gly Leu     1085 1090 1095 His Pro Ala Leu Leu Asp Ala Ala Gln His Ala Ala Ala Tyr Gly     1100 1105 1110 Asp Leu Gly Ala Ile Ser Arg Gly Gly Leu Pro Phe Thr Trp Glu     1115 1120 1125 Gly Val Gln Leu Phe Ala Ala Gly Ala Gly Thr Val Arg Ala Arg     1130 1135 1140 Ile Ala Ala Thr Gly Glu Asp Thr Val Ser Ile Thr Val Tyr Asp     1145 1150 1155 Ala Ala Gly Gly Pro Val Leu Thr Ala Asp Ser Leu Val Ser Arg     1160 1165 1170 Glu Val Pro Ala Asp Thr Gly Ala Asp Arg Tyr Asp Asp Ser Leu     1175 1180 1185 Phe Arg Gln Asp Trp Ala Pro Leu Gly Gly Pro Ala Gly Arg Thr     1190 1195 1200 Pro Ala Ala Val Ala Val Val Gly Ala Glu Thr Gly Gly Pro Gly     1205 1210 1215 Pro Val Gly Thr Ala Ala Leu Arg Ala Ala Gly Val Pro Val Arg     1220 1225 1230 Thr Tyr Pro Asp Leu Thr Ala Leu Ala Ala Ser Gly Asp Pro Val     1235 1240 1245 Pro Glu Leu Val Leu Ala Gly Ala Ala Ser Cys Gly Gly Thr Val     1250 1255 1260 Ala Asp Ala Ala His Thr Val Ala Thr Ala Ala Leu Glu Leu Val     1265 1270 1275 Gln Gln Trp Leu Ser Gly Glu Glu Phe Ala Asp Ala Arg Leu Val     1280 1285 1290 Leu Leu Thr Arg Gly Ala Thr Asp Gly Ala Asp Pro Ala Ala Ala     1295 1300 1305 Ala Val His Gly Leu Val Arg Thr Ala Arg Thr Glu Asn Pro Gly     1310 1315 1320 Arg Leu Ala Val Leu Asp Leu Pro Asp Asp Ala Thr Gly Ala Asp     1325 1330 1335 Pro Val Val Ala Pro Ala Ala Leu Val Ala Ala Leu Ala Ala Thr     1340 1345 1350 Glu Asp Glu Pro Asp Leu Ala Val Arg Ala Asp Thr Val Leu Val     1355 1360 1365 Pro Arg Leu Val Arg Val Arg Thr Asp Ala Glu Pro His Arg Trp     1370 1375 1380 Asn Pro Asp Gly Thr Val Leu Ile Thr Gly Gly Thr Gly Gly Leu     1385 1390 1395 Gly Gly Val Leu Ala Arg His Leu Val Ala Glu His Gly Val Arg     1400 1405 1410 Gln Leu Leu Leu Ala Gly Arg Arg Gly Pro Asp Ala Pro Gly Ala     1415 1420 1425 Ala Glu Leu Val Asp Glu Leu Thr Ala Leu Gly Ala Thr Ala His     1430 1435 1440 Ala Val Ala Cys Asp Val Thr Asp Arg Ala Ala Val Ala Ala Leu     1445 1450 1455 Leu Ala Gly Ile Pro Asp Thr His Pro Leu Thr Ala Val Val His     1460 1465 1470 Thr Ala Gly Val Val Asp Asp Gly Val Ile Gly Ser Leu Thr Pro     1475 1480 1485 Glu Arg Leu Asp Thr Val Leu Arg Pro Lys Ala Asp Ala Ala Trp     1490 1495 1500 His Leu His Glu Leu Thr Arg Asp Leu Asp Leu Asp Ala Phe Val     1505 1510 1515 Leu Phe Ser Ser Val Ala Ala Thr Phe Gly Ser Pro Gly Gln Ala     1520 1525 1530 Asn Tyr Ala Ala Gly Asn Ala Phe Leu Asp Ala Leu Ala Val His     1535 1540 1545 Arg Arg Ser Ala Gly Leu Pro Ala Val Ala Leu Ala Trp Gly Pro     1550 1555 1560 Trp Ser Arg Val Val Gly Met Thr Gly Ser Leu Ser Asp Val Asp     1565 1570 1575 Val Glu Arg Ile Ala Arg Ser Gly Met Pro Pro Leu Thr Pro Glu     1580 1585 1590 Gln Gly Thr Ala Leu Phe Asp Ala Ala Leu Ala Ala Thr Ala Asp     1595 1600 1605 Gly Thr Ala Ala Leu Ala Pro Val Arg Leu Asp Leu Pro Ala Leu     1610 1615 1620 Arg Ala Gln Gly Glu Pro Ala Pro Leu Leu Arg Gly Leu Ile Arg     1625 1630 1635 Arg Pro Ala Arg Arg Ala Ala Ala Gln Ala Ser Pro Ser Thr Gly     1640 1645 1650 Asp Leu Ala Glu Arg Leu Arg Ala Leu Asp Gly Ser Thr Arg Asp     1655 1660 1665 Glu Ala Leu Leu Asp Leu Val Arg Glu Arg Ile Ala His Val Leu     1670 1675 1680 Gly His Ala Asp Pro Gly Gln Val Glu Thr Gly Arg Gln Phe Gln     1685 1690 1695 Asp Leu Gly Phe Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Gly     1700 1705 1710 Leu Thr Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe     1715 1720 1725 Asp Tyr Pro Thr Pro Gly Val Leu Ala Arg His Leu Arg Asp Glu     1730 1735 1740 Leu Leu Gly Ala Asp Asp Ala Pro Asp Asp Thr Ala Asp Arg Thr     1745 1750 1755 Pro Asp Arg Thr Ala Ala Ser Ser Ala Ala Thr Gly Asp Asp Pro     1760 1765 1770 Val Val Ile Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val Gly     1775 1780 1785 Ser Pro Glu Asp Leu Trp Arg Leu Val Gly Asp Gly Ala Asp Ala     1790 1795 1800 Thr Gly Pro Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Asn Leu     1805 1810 1815 Phe Asp Ala Asp Pro Asp Arg Pro Gly His Thr His Val Arg Ala     1820 1825 1830 Gly Gly Phe Leu His Thr Ala Pro Glu Phe Asp Ala Gly Phe Phe     1835 1840 1845 Gly Met Ser Pro Arg Glu Ala Leu Ser Thr Asp Ser Gln Gln Arg     1850 1855 1860 Leu Leu Leu Glu Thr Ser Trp Glu Ala Ile Glu Arg Ala Gly Ile     1865 1870 1875 Asp Pro Thr Gly Leu Arg Gly Ser Ala Thr Gly Val Phe Ala Gly     1880 1885 1890 Val Met Tyr Asn Asp Tyr Gly Thr Thr Leu Thr Gly Asp Glu His     1895 1900 1905 Glu Ala Phe Arg Gly Asn Gly Ser Ala Pro Ser Val Ala Ser Gly     1910 1915 1920 Arg Val Ser Tyr Thr Leu Gly Leu Glu Gly Pro Ala Val Thr Val     1925 1930 1935 Asp Thr Ala Cys Ser Ser Ser Leu Val Gly Met His Leu Ala Ala     1940 1945 1950 Gln Ala Leu Arg Ala Gly Glu Cys Thr Leu Ala Leu Ala Gly Gly     1955 1960 1965 Val Thr Val Met Ser Thr Pro Ser Thr Phe Val Asp Phe Ser Arg     1970 1975 1980 Gln Arg Gly Leu Ala Pro Asp Gly Arg Ser Lys Ala Phe Ala Asp     1985 1990 1995 Ala Ala Asp Gly Val Ala Trp Ser Glu Gly Val Gly Val Leu Val     2000 2005 2010 Leu Glu Arg Arg Ser Asp Ala Leu Arg Asn Gly His Glu Ile Leu     2015 2020 2025 Ala Val Leu Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn     2030 2035 2040 Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg     2045 2050 2055 Arg Ala Leu Ala Asn Ala Gly Leu Ser Thr Gly Asp Val Asp Val     2060 2065 2070 Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu     2075 2080 2085 Ala Gln Ala Leu Ile Ala Thr Tyr Gly Arg Asp Arg Asp Pro Gln     2090 2095 2100 Arg Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Ile Gly His Thr     2105 2110 2115 Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Leu Ala     2120 2125 2130 Met Arg His Gly Thr Val Pro Arg Thr Leu His Val Asp Ala Pro     2135 2140 2145 Ser Ser His Val Asp Trp Ser Asp Gly Thr Val Ala Leu Leu Thr     2150 2155 2160 Glu Pro Thr Pro Trp Pro Glu Thr Gly Arg Pro Arg Arg Ala Gly     2165 2170 2175 Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Val     2180 2185 2190 Glu Gln Pro Glu Pro Thr Pro Thr Thr Ala Thr Val Gly Gly Arg     2195 2200 2205 Glu Leu Pro Ala Val Pro Trp Ala Leu Ser Gly Ala Ser Ala Asp     2210 2215 2220 Ala Leu Arg Asp Gln Ala Ala Arg Leu Leu Thr His Val Arg Asp     2225 2230 2235 Gly His Ala Val Asp Pro Ala Ile Asp Pro Ala Ile Asp Pro Ala     2240 2245 2250 Asp Val Gly Trp Ser Leu Leu Arg Thr Arg Ala Ala Leu Asp Gln     2255 2260 2265 Arg Ala Val Val Val Gly Thr Gly Ala Glu Gln Thr Leu Arg Gly     2270 2275 2280 Leu Ala Ala Leu Ala Ala Gly Glu Ala Asp Pro Ala Val Val Thr     2285 2290 2295 Gly Thr Thr Ala Thr Gly Arg Thr Ala Phe Leu Phe Ser Gly Gln     2300 2305 2310 Gly Ser Gln Arg Leu Gly Met Gly Arg Glu Leu His Ala Arg Tyr     2315 2320 2325 Pro Ala Phe Ala Asp Ala Phe Asp Ala Ala Leu Ser Ala Leu Asp     2330 2335 2340 Ala Glu Leu Gly Ser Asp Leu Arg Ala Val Val Trp Gly His Gly     2345 2350 2355 Asp Ser Ala Gly Ala Ala Leu Asp Ala Thr Gly Ala Thr Gln Pro     2360 2365 2370 Ala Leu Phe Ala Leu Glu Val Ala Leu Tyr Arg Leu Leu Glu Ser     2375 2380 2385 Trp Gly Val Ala Pro Asp Leu Val Ala Gly His Ser Val Gly Glu     2390 2395 2400 Ile Ala Ala Ala His Val Ala Gly Val Phe Thr Leu Ala Asp Ala     2405 2410 2415 Ala Arg Leu Val Ala Ala Arg Gly Thr Leu Met Gln Ala Leu Pro     2420 2425 2430 Ala Gly Gly Ala Met Val Ala Val Glu Ala Thr Glu Asp Glu Val     2435 2440 2445 Ala Ala Leu Leu Thr Arg Asp Asp Val Ala Ile Ala Ala Val Asn     2450 2455 2460 Gly Pro Ser Ala Val Val Val Ser Gly Ser Gln Asp Gly Val Asp     2465 2470 2475 Ala Val Ala Ala Ala Leu Ala Glu Gly Gly Arg Arg Thr Ser Arg     2480 2485 2490 Leu Arg Val Ser His Ala Phe His Ser Pro Leu Met Glu Pro Met     2495 2500 2505 Leu Ala Glu Phe Arg Ser Val Val Ala Gly Leu Ser Pro Glu Ala     2510 2515 2520 Pro Ala Val Pro Val Val Ser Ser Leu Thr Gly Asp Leu Ala Gly     2525 2530 2535 Ala Asp Glu Leu Cys Asp Pro Gly Tyr Trp Val Arg His Val Arg     2540 2545 2550 Glu Pro Val Arg Phe Ala Asp Ala Val Thr Thr Leu Ala Gly Arg     2555 2560 2565 Gly Ala Val Thr Phe Val Glu Ile Gly Pro Gly Gly Val Leu Ser     2570 2575 2580 Ala Met Ala Gln Asp Ser Leu Pro Ala Asp Gly Thr Val Thr Val     2585 2590 2595 Pro Val Leu His Gly Glu Gly Ser Glu Asp Val Ala Val Val Ala     2600 2605 2610 Ala Leu Ala Ala Leu His Val Arg Gly Val Arg Ile Asp Trp Asp     2615 2620 2625 Ala Val Phe Asp Gly Thr Gly Ala Ala Arg Val Asp Leu Pro Thr     2630 2635 2640 Tyr Ala Phe Gln His Arg Arg Tyr Trp Pro Gly Ala Thr Ala Ala     2645 2650 2655 Pro Gly Asp Val Arg Ser Ala Gly Leu Gly Ala Ala Gly His Pro     2660 2665 2670 Leu Leu Gly Ala Ala Val Ala Phe Pro Asp Gly Ala Gly Ala Leu     2675 2680 2685 Leu Thr Gly Arg Leu Ser Ala Ser Ala Gln Pro Trp Leu Ala Asp     2690 2695 2700 His Thr Val Ala Gly Thr Val Val Leu Pro Gly Thr Ala Leu Leu     2705 2710 2715 Glu Leu Ala Val Arg Ala Gly Asp Glu Val Gly Cys Thr Gly Val     2720 2725 2730 Glu Glu Leu Thr Leu Ala Thr Pro Leu Thr Leu Pro Thr Ala Gly     2735 2740 2745 Gly Ala Val Thr Val Gln Val Arg Ala Gly Ala Asp Asp Gly Ser     2750 2755 2760 Gly Arg Arg Pro Val Thr Val His Ala Arg Pro Glu Gly Ser Asp     2765 2770 2775 Glu Trp Thr Glu His Ala Thr Gly Thr Leu Thr Thr Leu Ala Pro     2780 2785 2790 Gly Pro Val Arg Phe Asp Ala Thr Thr Trp Pro Pro Thr Gly Ala     2795 2800 2805 Ala Glu Leu Asp Val Glu Gly Cys Tyr Glu Arg Phe Ala Glu Ala     2810 2815 2820 Gly Phe Gly Tyr Gly Pro Val Phe Arg Gly Leu Thr Gly Ala Trp     2825 2830 2835 Arg Asp Gly Asp Thr Val Tyr Ala Glu Val Ser Leu Pro Asp Pro     2840 2845 2850 Asp Thr Thr Ala Glu Asp Ala Ala Arg Phe Gly Leu His Pro Ala     2855 2860 2865 Leu Leu Asp Ala Ala Leu His Ala Ala Leu Leu Thr Gly Asp Gly     2870 2875 2880 Ala Ala Gly Leu Pro Trp Ala Trp Glu Asp Val Thr Leu His Ala     2885 2890 2895 Ala Gly Ala Thr Ala Leu Arg Val Arg Leu Ala Pro Ala Thr Asp     2900 2905 2910 Gly Gly Gly Leu Ala Val Ala Val Ala Asp Pro Glu Gly Arg Pro     2915 2920 2925 Val Ala Thr Ala Gly Arg Leu Arg Ala Arg Pro Val Asp Pro Ala     2930 2935 2940 Ala Leu Gly Thr Gly Thr Ala Val Arg Asp Gly Leu Phe Arg Leu     2945 2950 2955 Asp Trp Thr Ala Val Thr Ala Pro Ser Asp Gln Ser Val Pro Pro     2960 2965 2970 Ala Pro Val Ala Val Leu Gly Ala Pro Gly Asp Pro Val Thr Asp     2975 2980 2985 Val Leu Ala Ala Gly His Thr Arg Tyr Asp Thr Val Asp Asp Leu     2990 2995 3000 Leu Ala Asp Pro Gly Ser Thr Val Pro Ala Thr Val Leu Ala Pro     3005 3010 3015 Leu Pro Ala Gly Pro Gly Asp Asp Thr Pro Arg Asp Val Arg Asp     3020 3025 3030 Arg Thr Gly Ala Thr Leu Asp Leu Leu Arg Arg Trp Ser Thr Glu     3035 3040 3045 Asp Arg Leu Ala Gly Ser Arg Leu Val Leu Val Thr Arg Gly Ala     3050 3055 3060 Val Thr Asp Ala Gly Glu Pro Val Ala Asp Leu Ala Ala Ala Ala     3065 3070 3075 Val Trp Gly Leu Val Arg Ser Ala Gln Thr Glu Asn Pro Gly Ala     3080 3085 3090 Phe Gly Leu Leu Asp Leu Asp Pro Ala Ala Ala Val Pro Ala Thr     3095 3100 3105 Gly Ala Leu Pro Val Ala Leu Ser Pro Asp Glu Pro Gln Leu Ala     3110 3115 3120 Val Arg Gly Asp Asp Val Leu Ala Ala Arg Leu Thr Arg Ala Gly     3125 3130 3135 Ala Pro Thr Gly Ala Thr Thr Trp Ser Thr Glu Gly Thr Val Leu     3140 3145 3150 Val Thr Gly Gly Thr Gly Gly Leu Gly Gly Leu Leu Ala Arg His     3155 3160 3165 Leu Val Ala Thr His Gly Val Arg His Leu Leu Leu Thr Ser Arg     3170 3175 3180 Ser Gly Ala Asp Ala Pro Gly Ala Ala Glu Leu Val Ala Glu Leu     3185 3190 3195 Glu Gly His Gly Ala Arg Val Ser Val Ala Ala Cys Asp Val Thr     3200 3205 3210 Asp Ala Asp Ala Val Thr Ala Leu Val Ala Gly Val Pro Gly Ala     3215 3220 3225 His Pro Leu Arg Ala Val Val His Thr Ala Gly Ile Leu Asp Asp     3230 3235 3240 Gly Val Leu Ser Ser Leu Thr Pro Gly Arg Leu Ala Arg Val Leu     3245 3250 3255 Ala Pro Lys Val Asp Gly Ala Trp Asn Leu His Arg Ala Thr Ala     3260 3265 3270 Gly Leu Asp Leu Asp Ala Phe Val Leu Phe Ser Ser Val Ala Gly     3275 3280 3285 Val Phe Gly Gly Ala Gly Gln Ala Asn Tyr Ala Ala Gly Asn Ala     3290 3295 3300 Phe Leu Asp Ala Leu Ala Ala His Arg Ala Ala Ala Gly Leu Pro     3305 3310 3315 Ala Thr Ala Leu Ala Trp Gly Pro Trp Gln Gln Gly Leu Gly Met     3320 3325 3330 Thr Ala Asp Leu Asp Gln Arg Asp Val Ala Arg Ala Ala Ala Ala     3335 3340 3345 Gly Met Pro Leu Leu Thr Ala Asp Glu Gly Leu Ala Leu Phe Asp     3350 3355 3360 Ala Ala Pro Ala Thr Gly Asp Pro Ala Leu Val Thr Ala Arg Leu     3365 3370 3375 Asp Leu Ala Ala Phe Arg Ala Arg Thr Pro Val Pro Ala Leu Leu     3380 3385 3390 Arg Gly Leu Val Thr Ala Pro Arg Arg Thr Ala Ala Gly Ala Ala     3395 3400 3405 Gln Ala Thr Asp Ala Gly Leu Val Ala Arg Leu Ala Arg Leu Asp     3410 3415 3420 Asp Asp Arg Arg His Glu Val Leu Leu Asp Val Val Arg Asp Ala     3425 3430 3435 Ala Ala Leu Val Leu Gly His Thr Ser Gly Ala Asp Ile Asp Ala     3440 3445 3450 Asp Arg Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu Thr Ala Val     3455 3460 3465 Glu Leu Arg Asn Arg Leu Ala Thr Ala Thr Gly Leu Arg Leu Pro     3470 3475 3480 Ala Thr Thr Val Phe Asp His Pro Thr Leu Ser Ala Leu Ala Thr     3485 3490 3495 His Leu Arg Ser Glu Leu Leu Gly Ser Ala Ala Pro Pro Ala Pro     3500 3505 3510 Glu Arg Pro Val Val Thr Pro Leu Asp Asp Asp Pro Val Val Ile     3515 3520 3525 Val Gly Met Ala Cys Arg Phe Pro Gly Gly Val Thr Ser Pro Glu     3530 3535 3540 Asp Leu Trp Gln Leu Val Gly Asp Gly Val Asp Ala Ile Thr Gly     3545 3550 3555 Phe Pro Thr Gly Arg Gly Trp Asp Leu Asp Gly Leu Tyr Asp Pro     3560 3565 3570 Asp Pro Asp His Ala Gly Thr Ser Tyr Thr Arg Glu Gly Gly Phe     3575 3580 3585 Leu His Asp Ala Ala Glu Phe Asp Ala Gly Phe Phe Gly Met Ser     3590 3595 3600 Pro Arg Glu Ala Thr Ala Thr Asp Ala Gln Gln Arg Leu Leu Leu     3605 3610 3615 Glu Thr Ser Trp Glu Ala Val Glu Arg Ala Gly Ile Asp Pro Val     3620 3625 3630 Ser Leu Arg Gly Ser Ala Thr Gly Val Phe Ala Gly Val Met Tyr     3635 3640 3645 His Asp Tyr Ala Asp Asn Leu Gly Gly Pro Glu His Glu Gly Ile     3650 3655 3660 Gln Gly Gln Gly Ser Ala Gly Ser Val Ala Ser Gly Arg Val Ser     3665 3670 3675 Tyr Thr Leu Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala     3680 3685 3690 Cys Ser Ser Ser Leu Val Ala Met His Trp Ala Met Gln Ala Leu     3695 3700 3705 Arg Thr Gly Glu Cys Thr Leu Ala Leu Ala Gly Gly Val Thr Val     3710 3715 3720 Met Ser Thr Pro Ala Thr Phe Val Glu Phe Ser Arg Gln Gly Gly     3725 3730 3735 Leu Ala Ala Asp Gly Arg Ser Lys Pro Phe Ala Asp Ala Ala Asp     3740 3745 3750 Gly Val Gly Trp Ala Glu Gly Ala Gly Met Leu Val Leu Glu Arg     3755 3760 3765 Arg Ser Asp Ala Leu Arg Asn Gly His Glu Ile Leu Ala Val Val     3770 3775 3780 Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr     3785 3790 3795 Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu     3800 3805 3810 Ala Ser Ala Gly Leu Arg Ala Ser Asp Val Asp Ala Val Glu Ala     3815 3820 3825 His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala     3830 3835 3840 Leu Ile Ala Thr Tyr Gly Ala Asp Arg Asp Pro Ala Gln Pro Leu     3845 3850 3855 His Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala     3860 3865 3870 Ala Gly Val Ala Gly Val Ile Lys Met Val Gln Ala Leu Arg His     3875 3880 3885 Gly Val Leu Pro Arg Thr Leu His Val Asp Ala Pro Ser Ser His     3890 3895 3900 Val Asp Trp Ser Asp Gly Thr Val Ala Leu Leu Thr Glu Pro Thr     3905 3910 3915 Val Trp Pro Glu Thr Gly Arg Val Arg Arg Ala Gly Val Ser Ser     3920 3925 3930 Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Val Glu Gln Pro     3935 3940 3945 Ala Asp Ala Pro Ala Pro Ser Pro Ala Glu Pro Gly Pro Asp Gly     3950 3955 3960 Pro Leu Pro Trp Leu Leu Ser Ala Arg Ser Pro Glu Ala Leu Arg     3965 3970 3975 Asp Gln Ala Ala Arg Leu Arg Asp Ala Val Thr Gly Arg Pro Asp     3980 3985 3990 Leu Arg Pro Ile Asp Val Ala His Ser Leu Ala Thr Gly Arg Ser     3995 4000 4005 Ala Phe Asp His Arg Ala Val Val Leu Ala Ala Asp Ala Asp Asp     4010 4015 4020 Ala Val Arg Ala Leu Thr Ala Leu Ala Asp Gly Asp Ser Asp Pro     4025 4030 4035 Ala Val Val Thr Gly Arg Ala Arg Gly Gly Arg Thr Ala Met Leu     4040 4045 4050 Phe Ser Gly Gln Gly Ser Gln Arg Leu Gly Met Gly Arg Glu Leu     4055 4060 4065 His Ala Arg Phe Pro Val Phe Ala Asp Ala Phe Asp Ala Val Val     4070 4075 4080 Ala Ala Leu Asp Ala Glu Leu Gly Gly Asp Leu Arg Ala Val Val     4085 4090 4095 Trp Gly Thr Asp Ala Ala Ala Leu Asp Glu Thr Gly Ala Thr Gln     4100 4105 4110 Pro Ala Leu Phe Ala Val Glu Val Ala Leu His Arg Leu Val Glu     4115 4120 4125 Ser Trp Gly Val Arg Ala Asp Leu Val Ala Gly His Ser Ile Gly     4130 4135 4140 Glu Ile Ala Ala Ala His Val Ala Gly Val Phe Ser Leu Ala Asp     4145 4150 4155 Ala Ala Arg Leu Val Ala Ala Arg Ala Ser Leu Met Gln Ala Leu     4160 4165 4170 Pro Thr Gly Gly Ala Met Leu Ala Val Gln Ala Ser Glu Asp Glu     4175 4180 4185 Val Arg Pro His Leu Thr Asp Gly Val Ala Ile Ala Ala Val Asn     4190 4195 4200 Gly Pro Ser Ala Val Val Val Ser Gly Asp Glu Asp Ala Val Thr     4205 4210 4215 Ala Val Gly Glu Gln Leu Ala Gly Arg Arg Thr Arg Arg Leu Ala     4220 4225 4230 Val Ser His Ala Phe His Ser Pro Leu Met Asp Pro Met Leu Ala     4235 4240 4245 Glu Phe Arg Ala Val Ala Glu Gln Leu Ser Tyr Ala Glu Pro Val     4250 4255 4260 Val Pro Val Val Ser Asn Leu Thr Gly Ala Leu Ala Glu Pro Arg     4265 4270 4275 Gln Leu Cys Asp Pro Glu Tyr Trp Val Arg His Val Arg Glu Ala     4280 4285 4290 Val Arg Phe Gly Asp Gly Val Arg Ala Leu Ala Gly Ala Gly Ala     4295 4300 4305 Thr Thr Phe Leu Glu Leu Gly Pro Asp Gly Val Leu Ser Ala Met     4310 4315 4320 Ala Arg Glu Ser Leu Pro Asp Asp Thr Thr Ala Thr Val Pro Val     4325 4330 4335 Leu Arg Arg Asp Arg Gly Glu Val Asp Ala Ala Leu Thr Ala Leu     4340 4345 4350 Ala Arg Leu His Val Gly Gly Thr Arg Val Gly Trp Thr Glu Leu     4355 4360 4365 Leu Pro Gly Gly Arg Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln     4370 4375 4380 His Ala Thr Tyr Trp Pro Thr Ala Thr Arg Pro Ala Ala Asp Ala     4385 4390 4395 Gly Ala Leu Gly Leu Thr Ala Thr Gly His Pro Val Leu His Gly     4400 4405 4410 Val Val Glu Leu Ala Glu Gly Glu Gly Val Leu Cys Thr Gly Arg     4415 4420 4425 Leu Ser Leu Ala Thr His Pro Trp Leu Thr Asp His Ala Val Arg     4430 4435 4440 Gly Thr Val Leu Val Pro Gly Thr Ala Leu Leu Glu Leu Ala Leu     4445 4450 4455 Arg Ala Gly Asp Glu Val Gly Cys Asp Arg Val Glu Glu Leu Thr     4460 4465 4470 Leu Ala Ala Pro Leu Val Val Pro Thr Arg Gly Ala Val Arg Thr     4475 4480 4485 Gln Val Arg Val Gly Val Ala Asp Asp Asp Gly Arg Arg Thr Val     4490 4495 4500 Thr Val His Ala Arg Pro Asp Asp Ala Gly Asp Ala Pro Trp Thr     4505 4510 4515 Gln His Ala Ala Gly Thr Leu Thr Thr Ala Ala Pro Glu Pro Thr     4520 4525 4530 Gly Phe Asp Ala Thr Thr Trp Pro Pro Thr Gly Ala Arg Glu Leu     4535 4540 4545 Pro Leu Arg Gly Cys Tyr Glu Arg Phe Ala Glu Ala Gly Phe Gly     4550 4555 4560 Tyr Gly Pro Val Phe Gln Gly Leu Thr Gly Ala Trp Gln Asp Gly     4565 4570 4575 Asp Thr Val Tyr Ala Glu Val Ala Leu Pro Gly Gln Ala Thr Asp     4580 4585 4590 Asp Ala Ala Arg Phe Gly Leu His Pro Ala Leu Leu Asp Ala Ala     4595 4600 4605 Leu His Ala Gly Met Leu Asp Asp Asp Gly Thr Ala Gly Leu Pro     4610 4615 4620 Phe Ser Trp Asp Gly Val Thr Leu His Ala Thr Gly Ala Val Ala     4625 4630 4635 Leu Arg Val Arg Leu Thr Arg Thr Gly Gly Gly Ile Ala Ile Ala     4640 4645 4650 Ala Ala Asp Pro Ala Gly His Pro Val Ala Thr Val Asp Thr Leu     4655 4660 4665 Ala Val Arg Pro Val Ala Glu Ala Gln Leu Ala Pro Thr Gly Thr     4670 4675 4680 Gly Asp Ala Leu Phe Ala Leu Asp Trp Thr Pro Val Asp Asp Ala     4685 4690 4695 Pro Ala Gly Ile Pro Ala Pro Ala Thr Val Ala Val Val Gly Ile     4700 4705 4710 Gly Val Gly Asp Asp His Gly Asp Ser Ala Ala Ala Glu Val Ala     4715 4720 4725 Ala Gly Leu Ser Ala Ala Gly Thr Asp Ala Thr Val His Thr Gly     4730 4735 4740 Pro Ala Thr Ala Ile Glu Glu Leu Gly Asp Thr Val Val Val Thr     4745 4750 4755 Val Asp Gly Glu Gly Ala Asp Thr Ala Thr Ala Ala His Thr Leu     4760 4765 4770 Thr Ala Ala Val Leu Asp Leu Leu Gln Gln Trp Thr Ala Gly Thr     4775 4780 4785 Gly Ser Gly Arg Leu Ala Val Val Thr Arg Gly Ala Val Ala Ala     4790 4795 4800 Gly Gly Thr Ala Pro Thr Asp Val Ala Ala Ala Ala Val His Gly     4805 4810 4815 Leu Val Arg Ser Ala Arg Ser Glu Phe Pro Asp Gly Ile Val Leu     4820 4825 4830 Val Asp Leu Asp Pro Ala Thr Ala Gly Ala Ala Asp Asp Gly Pro     4835 4840 4845 Leu Leu Leu Ala Ala Leu His Thr Gly Glu Pro Gln Ile Ala Val     4850 4855 4860 Arg Asp Gly Ala Leu Leu Ala Gly Arg Leu Thr Arg Ala Gln Thr     4865 4870 4875 Gly Ser Gly Leu Val Val Pro Ala Val Asp Ala Trp Cys Leu Asp     4880 4885 4890 Ser Thr Thr Pro Gly Ser Ile Asp Gly Leu Ala Leu Val Pro His     4895 4900 4905 Pro Glu Ala Gly Ala Pro Leu Thr Gly His Gln Val Arg Val Ala     4910 4915 4920 Ile Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Leu Lys Ser Leu     4925 4930 4935 Asp Met Tyr Pro Gly Asp Ala Gly Arg Tyr Gly His Glu Ala Ala     4940 4945 4950 Gly Val Val Leu Ala Thr Gly Pro Asp Val Thr Gly Leu Ala Pro     4955 4960 4965 Gly Asp Arg Val Leu Gly Met Ile Ser Gly Ser Phe Ser Ser Val     4970 4975 4980 Ala Val Asp Asp Ala Arg Arg Leu Thr Arg Ile Pro Asp Gly Trp     4985 4990 4995 Asp Trp Glu Thr Ala Ala Ser Val Pro Leu Val Phe Leu Thr Ala     5000 5005 5010 Trp His Ala Leu Arg Gln Leu Gly Asn Leu Thr Ala Gly Glu Lys     5015 5020 5025 Val Leu Val His Ala Gly Ala Gly Gly Val Gly Met Ala Ala Val     5030 5035 5040 Gln Ile Ala Arg His Leu Gly Ala Glu Val Tyr Ala Thr Ala Ser     5045 5050 5055 Glu Pro Lys Gln His Val Leu Arg Ser Leu Gly Val Ala Glu Asp     5060 5065 5070 His Ile Ala Ser Ser Arg Thr Leu Glu Phe Ala Glu Thr Phe Ala     5075 5080 5085 Gly Thr Asp Leu Asp Val Val Leu Asn Ser Leu Ala Gly Glu Phe     5090 5095 5100 Val Asp Ala Ser Met Gly Leu Leu Gly Asp Gly Gly Arg Phe Leu     5105 5110 5115 Glu Met Gly Lys Thr Asp Ile Arg Asp Ala Asp Ser Ala Pro Ala     5120 5125 5130 Gly Val Ser Tyr Gln Ala Phe Asp Leu Ala Trp Val Glu Pro Glu     5135 5140 5145 Ala Ile Gly Ala Met Phe Ala Glu Leu Met Asp Leu Phe Ala Ala     5150 5155 5160 Gly Val Leu Asp Pro Leu Pro Val Arg Thr Trp Asp Val Arg Asp     5165 5170 5175 Ala Pro Ala Ala Phe Arg Phe Met Ser Ala Ala Gln His Ile Gly     5180 5185 5190 Lys Ile Val Leu Thr Leu Pro Arg Pro Trp Thr Thr Glu Gly Thr     5195 5200 5205 Val Leu Val Thr Gly Gly Thr Gly Gly Leu Gly Gly Leu Leu Ala     5210 5215 5220 Arg His Leu Val Ala Thr His Gly Val Arg His Leu Leu Leu Thr     5225 5230 5235 Ser Arg Ser Gly Ala Asp Ala Pro Gly Ala Ala Glu Leu Val Ser     5240 5245 5250 Glu Leu Gly Glu Leu Gly Ala Gln Val Ser Val Ala Ala Cys Asp     5255 5260 5265 Val Thr Asp Ala Asp Ala Val Ala Ala Leu Val Ala Gly Val Pro     5270 5275 5280 Gly Gly His Pro Leu Arg Ala Val Val His Thr Ala Gly Val Leu     5285 5290 5295 Asp Asp Gly Val Leu Ala Ser Leu Thr Pro Gly Arg Leu Ala Arg     5300 5305 5310 Val Leu Ala Pro Lys Val Asp Gly Ala Trp Asn Leu His Arg Ala     5315 5320 5325 Thr Glu His Leu Asp Leu Asp Ala Phe Val Leu Phe Ser Ser Val     5330 5335 5340 Ala Gly Val Phe Gly Gly Ala Gly Gln Ala Asn Tyr Ala Ala Gly     5345 5350 5355 Asn Ala Phe Leu Asp Ala Leu Ala Ala His Arg Ala Ala Ala Gly     5360 5365 5370 Leu Pro Gly Val Ser Leu Ala Trp Gly Ala Trp Gly Gln Glu Ala     5375 5380 5385 Gly Met Thr Ala Gly Leu Asp Glu Arg Asp Val Arg Arg Ala Ala     5390 5395 5400 Glu Ser Gly Met Pro Leu Leu Ala Ala Gly Gln Ala Leu Ala Leu     5405 5410 5415 Phe Asp Ala Ala Leu Ala Thr Gly Arg Pro Ala Leu Val Pro Val     5420 5425 5430 Arg Leu Asp Leu Ala Thr Leu His Arg Arg Gly Thr Val Pro Pro     5435 5440 5445 Leu Leu Arg Gly Leu Val Arg Ala Pro Ala Arg Arg Ala Ala Thr     5450 5455 5460 Thr Thr Ala Ala Asp Ala Gly Gly Leu Ala Gly Arg Leu Gly Ala     5465 5470 5475 Leu Gly Arg Ala Glu Arg Arg Ala Ala Leu Leu Asp Leu Val Arg     5480 5485 5490 Gly Glu Ala Ala Thr Val Leu Gly His Ala Gly Gly Asp Arg Ile     5495 5500 5505 Asp Pro Glu Leu Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu Thr     5510 5515 5520 Ala Val Glu Leu Arg Asn Lys Leu Gly Ala Ala Thr Gly Leu Arg     5525 5530 5535 Leu Pro Ala Thr Ala Ile Phe Asp Tyr Pro Thr Val Val Ala Leu     5540 5545 5550 Ala Glu His Leu Leu Val Gly Leu Leu Gly Pro Asp Ala Asp Gly     5555 5560 5565 Asp Ser Gly Thr Gly Ala Asp Ile Ala Gly Ile Thr Thr Ala Asp     5570 5575 5580 Asp Pro Val Val Val Val Gly Met Ser Cys Arg Phe Pro Gly Gly     5585 5590 5595 Ile Gly Ser Pro Glu Asp Leu Trp Arg Val Leu Asp Glu Gly Thr     5600 5605 5610 Asp Val Ile Ala Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp     5615 5620 5625 Asp Leu Phe Asp Asp Asp Pro Ala His Arg Gly Thr Ser Tyr Ala     5630 5635 5640 Arg Ser Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala Asp     5645 5650 5655 Phe Phe Gly Met Ser Pro Arg Glu Ala Met Ala Thr Asp Ala Gln     5660 5665 5670 Gln Arg Leu Leu Leu Glu Ser Ser Trp Glu Ala Ile Glu Arg Ala     5675 5680 5685 Gly Leu Asp Pro His Ser Leu Arg Asp Ser Arg Thr Gly Val Phe     5690 5695 5700 Ala Gly Val Met Tyr Ser Gly Tyr Gly Thr Arg Leu Asp Gly Asp     5705 5710 5715 Glu Phe Glu Gly Phe Gln Gly Gln Gly Ser Ala Leu Ser Val Ala     5720 5725 5730 Ser Gly Arg Ile Ser Tyr Ser Phe Gly Phe Glu Gly Pro Ala Met     5735 5740 5745 Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu     5750 5755 5760 Ala Ala Gln Ala Leu Arg Gly Gly Glu Cys Asp Arg Ala Leu Ala     5765 5770 5775 Gly Gly Val Thr Val Met Ala Gly Pro Glu Thr Phe Val Glu Phe     5780 5785 5790 Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Ser Lys Pro Phe     5795 5800 5805 Ser Glu Ser Ala Asp Gly Val Gly Trp Ser Glu Gly Val Gly Met     5810 5815 5820 Leu Leu Leu Glu Arg Gln Ser Asp Ala Leu Arg His Gly His Arg     5825 5830 5835 Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala     5840 5845 5850 Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val     5855 5860 5865 Ile Arg Gln Ala Leu Ala Ser Gly Gly Leu Ser Thr Ala Asp Val     5870 5875 5880 Asp Ala Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro     5885 5890 5895 Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Gln Asp Arg Glu     5900 5905 5910 Gln Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Met Gly His Thr     5915 5920 5925 Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Ile Met Ala     5930 5935 5940 Met Gln His Gly Val Leu Pro Arg Thr Leu Gly Val Thr Glu Pro     5945 5950 5955 Ser Ser His Val Asp Trp Asp Ala Gly Ala Val Glu Leu Leu Thr     5960 5965 5970 Glu Gln Thr Pro Trp Pro Glu Thr Gly Arg Ala Arg Arg Ala Gly     5975 5980 5985 Ile Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Val Leu     5990 5995 6000 Glu Gln Pro Ser Pro Val Glu Pro Ala Asp Ala Val Ala Pro Ala     6005 6010 6015 Pro Ala Arg Asp Gly Leu Ala Pro Leu Val Leu Ser Gly Arg Thr     6020 6025 6030 Pro Glu Ala Leu Arg Gly Gln Ala Asp Arg Leu Arg Ala His Leu     6035 6040 6045 Gln Asp Arg Ser Gly Leu Val Pro Ala Asp Val Ala Ser Ala Leu     6050 6055 6060 Ala Ser Ser Arg Ser Arg Phe Ala His Arg Ala Ala Val Leu Ala     6065 6070 6075 Gly Asp Arg Asp Asp Ala Leu Arg Ala Leu Ala Ala Leu Ala Ala     6080 6085 6090 Asp Thr Pro Asp Pro Ala Val Val Thr Gly Thr Ala Arg Pro Gly     6095 6100 6105 Arg Thr Ala Val Val Phe Ser Gly Gln Gly Ser Gln Arg Leu Gly     6110 6115 6120 Met Gly Arg Glu Leu Tyr Gly Arg Phe Pro Val Phe Ala Glu Ala     6125 6130 6135 Phe Asp Ala Val Val Ala Val Leu Asp Ala Glu Leu Gly Gly Asp     6140 6145 6150 Leu Arg Ala Leu Val Trp Gly Thr Asp Ala Ala Ala Leu Asp Glu     6155 6160 6165 Thr Gly Thr Ala Gln Pro Ala Leu Phe Ala Val Glu Val Ala Leu     6170 6175 6180 His Arg Leu Val Glu Ser Trp Gly Val Arg Ala Asp Leu Val Ala     6185 6190 6195 Gly His Ser Ile Gly Glu Ile Ala Ala Ala His Val Ala Gly Val     6200 6205 6210 Phe Ser Leu Ala Asp Ala Ala Arg Leu Val Ala Ala Arg Ala Ser     6215 6220 6225 Leu Met Gln Ala Leu Pro Thr Gly Gly Ala Met Val Ala Val Arg     6230 6235 6240 Ala Thr Glu Glu Gln Val Arg Pro His Leu Thr Asp Asp Val Ala     6245 6250 6255 Val Ala Ala Val Asn Gly Pro Ala Ser Leu Val Leu Ala Gly Ala     6260 6265 6270 Arg Asp Ala Val Leu Ala Val Ala Glu Gln Leu Arg Ala Gln Gly     6275 6280 6285 Arg Ser Val Thr Thr Leu Arg Val Ser His Ala Phe His Ser Pro     6290 6295 6300 Leu Met Asp Pro Met Leu Glu Glu Phe Arg Ala Val Ala Glu Gln     6305 6310 6315 Leu Thr Tyr Thr Glu Pro Val Val Pro Val Val Ser Asn Val Thr     6320 6325 6330 Gly Ala Leu Ala Gly Pro Gly Gln Leu Cys Val Pro Gly Tyr Trp     6335 6340 6345 Val Arg His Val Arg Glu Ala Val Arg Phe Gly Asp Gly Val Arg     6350 6355 6360 Ala Leu Ala Glu Ala Gly Ala Thr Thr Phe Leu Glu Leu Gly Pro     6365 6370 6375 Asp Gly Val Leu Ser Ala Met Ala Arg Glu Ser Leu Pro Glu Asp     6380 6385 6390 Thr Thr Val Thr Val Pro Val Leu Arg Arg Asp Arg Asp Glu Glu     6395 6400 6405 Arg Thr Ala Leu Thr Ala Leu Ala Thr Leu His Thr Thr Gly Val     6410 6415 6420 Pro Val Asp Trp Thr Ala Leu Leu Pro Ala Gly Pro Asp His Val     6425 6430 6435 Asp Leu Pro Thr Tyr Ala Phe Gln His Arg His Phe Trp Pro Ser     6440 6445 6450 Gly Ala Thr Gly Ala Pro Ala Gly Thr Gly Thr Thr Gly His Pro     6455 6460 6465 Leu Ala Gly Ser Val Val Ala Leu Ala Asp Gly Glu Gly Leu Val     6470 6475 6480 Leu Thr Gly Arg Ile Ser Thr Arg Thr Gln Pro Trp Leu Ala Asp     6485 6490 6495 His Ala Val Gly Gly Arg Val Leu Leu Pro Gly Thr Ala Phe Val     6500 6505 6510 Glu Leu Val Leu Arg Ala Gly Glu Glu Val Gly Cys Asp His Val     6515 6520 6525 Glu Glu Leu Thr Leu Thr Ala Pro Leu Val Leu Pro Asp Asp Glu     6530 6535 6540 Thr Val Arg Thr Gln Val Arg Leu Gly Ala Ala Asp Ala Ala Gly     6545 6550 6555 Arg Arg Pro Val Thr Val His Ser Arg Pro His Gly Thr Asp Asp     6560 6565 6570 Asp Pro Asp Pro Asp Ala Gly Trp Thr Leu His Ala Thr Gly Thr     6575 6580 6585 Leu Val Thr Ala Leu Pro Pro Val Pro Asp Pro Leu Asp Gly Ile     6590 6595 6600 Trp Pro Pro Ala Gly Ala Glu Pro Val Asp Leu Asp Gly Phe Tyr     6605 6610 6615 Pro Ala Arg Ala Ala Glu Gly Phe Ala Tyr Gly Pro Ser Phe Gln     6620 6625 6630 Gly Leu Arg Ala Ala Trp Arg Arg Asp Gly Glu Val Phe Ala Glu     6635 6640 6645 Leu Ala Leu Pro Glu Pro Ala Asp Gly Thr Ala Thr Ala Tyr Ala     6650 6655 6660 Leu His Pro Ala Leu Leu Asp Ala Ala Leu Gln Ser Ala Trp Leu     6665 6670 6675 Ala Glu Asp Arg Gly Gly Asp Thr Ala Gly Thr Thr Ala Ala Gly     6680 6685 6690 Val Pro Phe Ala Trp Ser Gly Val Ser Leu Ala Ala Ala Gly Ala     6695 6700 6705 Ser Ala Leu Arg Ala Arg Leu Arg Arg Asp Pro Asp Gly Thr Leu     6710 6715 6720 Thr Val Ser Ala Thr Asp Thr Gly Gly Ala Pro Val Ala Glu Val     6725 6730 6735 Arg Ala Leu Glu Met Arg Pro Val Gly Thr Pro Asp Asp Val Ala     6740 6745 6750 Pro Gly Val Arg Asp Ala Leu Phe Gly Leu Asp Trp Thr Pro Val     6755 6760 6765 Pro Asp Ala Gly Pro Leu Pro Asp Ala Thr Thr Ala Val Leu Val     6770 6775 6780 Gly Asp Asp Pro Phe Asp Leu Thr Gly Ala Leu Ala Glu Leu Gly     6785 6790 6795 Ala Thr Val Glu His His Asp Asp Leu Pro Ala Gly Thr Pro Ala     6800 6805 6810 Gly Pro Val Leu Leu Pro Val Ala Ala Pro Ala Asp Pro Gly Gly     6815 6820 6825 Glu Asp Ala Ala Ala Ala Ala His Thr Leu Thr Ala Arg Val Leu     6830 6835 6840 Gly Leu Val Arg Ala Arg Leu Glu Gln Glu Arg Phe Ala Gly Thr     6845 6850 6855 Arg Phe Leu Val Val Thr Arg Gly Ala Thr Thr Gly His Asp Pro     6860 6865 6870 Ala Ala Ala Ala Val Trp Gly Leu Val Arg Ser Ala Gln Ser Glu     6875 6880 6885 Asn Pro Gly Ala Phe Gly Leu Leu Asp Leu Asp Pro His Ala Ala     6890 6895 6900 Ala Thr Leu Pro Ala Ala Ala Leu Gly Gly Asp Glu Pro Gln Leu     6905 6910 6915 Arg Thr His Gly Gly Glu Leu Arg Ala Ala Arg Leu Ala Arg Arg     6920 6925 6930 Ala Pro Ala Gly Asp Asp Thr Ala Ala Ala Gly Leu Gly Ala Gly     6935 6940 6945 Thr Val Leu Val Thr Gly Gly Thr Gly Gly Leu Gly Ala Val Leu     6950 6955 6960 Ala Arg His Leu Val Ala Ala His Asp Val Arg Glu Leu Leu Leu     6965 6970 6975 Val Ser Arg Arg Gly Pro Asp Ala Glu Gly Ala Ala Asp Leu Val     6980 6985 6990 Ala Asp Leu Ala Asp Ala Gly Ala Arg Ala Thr Val Val Ala Cys     6995 7000 7005 Asp Val Ser Asp Arg Asp Ala Val Thr Ala Leu Leu Asp Asp His     7010 7015 7020 Pro Val His Ala Val Val His Ala Ala Gly Val Leu Asp Asp Gly     7025 7030 7035 Leu Val Ala Thr Leu Thr Pro Glu Arg Leu Ala Ala Val Leu Arg     7040 7045 7050 Pro Lys Val Asp Ala Ala Trp His Leu His Glu Ala Thr Arg Asp     7055 7060 7065 Arg Asp Leu Ala Ala Phe Val Met Phe Ser Ser Val Ala Gly Val     7070 7075 7080 Leu Gly Asn Pro Gly Gln Ala Asn Tyr Ala Ala Gly Asn Ala Phe     7085 7090 7095 Leu Asp Ala Leu Ala Leu Arg Arg Arg Thr Glu Gly Leu Pro Gly     7100 7105 7110 Thr Ala Leu Ala Trp Gly Pro Trp Glu Gln Gly Met Ala Gly Glu     7115 7120 7125 Leu Thr Glu Ala Glu Ala Ala Arg Leu Ala Arg Ser Gly Val Pro     7130 7135 7140 Ala Leu Thr Val Glu His Gly Leu Ala Leu Phe Asp Ala Ala Leu     7145 7150 7155 Ala Thr Gly Glu Pro Ala Leu Ala Pro Met Arg Leu Asp Pro Ala     7160 7165 7170 Ala Leu Arg Ala His Gly Glu Val Pro Ala Val Leu Arg Ala Leu     7175 7180 7185 Val Arg Gly Arg Ser Arg Arg Ala Ala Val Ala Gly Ser Ala Ala     7190 7195 7200 Ala Ser Gly Leu Arg Asp Arg Leu Ala Pro Leu Thr Pro Glu Glu     7205 7210 7215 Arg Arg Glu Val Leu Leu Asp Leu Val Arg Gly Gln Val Ala Leu     7220 7225 7230 Val Leu Gly His Ala Gly Ala Ala Asp Val Asp Ala Gly Arg Ala     7235 7240 7245 Phe Arg Asp Leu Gly Phe Asp Ser Leu Thr Ser Val Glu Leu Arg     7250 7255 7260 Asn Arg Leu Asn Thr Val Thr Gly Leu Arg Leu Pro Ala Thr Met     7265 7270 7275 Val Phe Asp His Pro Thr Val Asp Leu Leu Val Asp Val Ile Ala     7280 7285 7290 Asp Asp Leu Phe Gly Thr Asp Asp Asp Leu Pro Ala Ala Pro Val     7295 7300 7305 Arg Thr Ala Ala Val Ala Asp Asp Pro Ile Val Ile Val Gly Met     7310 7315 7320 Ala Ser Arg Tyr Pro Gly Gly Val Ala Thr Pro Asp Asp Leu Trp     7325 7330 7335 Thr Leu Val Thr Ser Gly Gly Asp Ala Ile Thr Gly Phe Pro Thr     7340 7345 7350 Asp Arg Gly Trp Asp Leu Glu Asn Leu Tyr His Pro Asp Ala Asp     7355 7360 7365 His Leu Gly Thr Ser Tyr Thr Arg Glu Gly Gly Phe Leu His Asp     7370 7375 7380 Ala Ala Glu Phe Asp Ala Gly Phe Phe Gly Met Ser Pro Arg Glu     7385 7390 7395 Ala Thr Ala Thr Asp Ala Gln Gln Arg Leu Leu Leu Glu Thr Ser     7400 7405 7410 Trp Glu Ala Val Glu Arg Ala Gly Ile Asp Pro Val Ser Leu Arg     7415 7420 7425 Gly Ser Ala Thr Gly Val Phe Ala Gly Val Met Tyr Ser Asp Tyr     7430 7435 7440 Gly Thr Val Leu Ala Gly Pro Glu Tyr Glu Gly Phe Gln Gly Ser     7445 7450 7455 Gly Ser Ser Pro Ser Val Ala Ser Gly Arg Val Ser Tyr Thr Leu     7460 7465 7470 Gly Leu Glu Gly Pro Ala Val Thr Ile Asp Thr Ala Cys Ser Ser     7475 7480 7485 Ser Leu Val Ala Met His Trp Ala Met Gln Ala Leu Arg Ser Gly     7490 7495 7500 Glu Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val Met Ser Thr     7505 7510 7515 Pro Gly Val Phe Val Asp Phe Ala Arg Gln Arg Gly Leu Ser Pro     7520 7525 7530 Asp Gly Arg Cys Lys Ala Phe Ser Asp Asp Ala Asp Gly Val Gly     7535 7540 7545 Trp Ala Glu Gly Ala Gly Met Leu Val Leu Glu Arg Gln Ser Asp     7550 7555 7560 Ala Leu Arg Asn Gly His Glu Ile Leu Ala Val Val Arg Gly Ser     7565 7570 7575 Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn     7580 7585 7590 Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Ser Gly     7595 7600 7605 Gly Leu Ser Thr Gly Asp Val Asp Val Val Glu Ala His Gly Thr     7610 7615 7620 Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala     7625 7630 7635 Thr Tyr Gly Arg Asp Arg Asp Thr Asp Arg Pro Leu Leu Leu Gly     7640 7645 7650 Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val     7655 7660 7665 Ala Gly Val Ile Lys Met Val Gln Ala Met Arg His Gly Thr Leu     7670 7675 7680 Pro Ala Thr Leu His Ala Gly Val Pro Ser Ser His Val Asp Trp     7685 7690 7695 Ser Asp Gly Thr Val Ala Leu Leu Thr Glu Gln Arg Ala Trp Pro     7700 7705 7710 Glu Thr Gly Arg Ala Arg Arg Ala Ala Val Ser Ser Phe Gly Ile     7715 7720 7725 Ser Gly Thr Asn Ala His Val Ile Leu Glu Gln Pro Ala Thr Asp     7730 7735 7740 Ala Ser Gly Pro Val Ala Thr Pro Asp Gly Thr Asp His Asp Arg     7745 7750 7755 Ala Val Pro Trp Val Leu Ser Gly Arg Thr Pro Glu Ala Leu Ala     7760 7765 7770 Gly Gln Ala Gly Lys Leu Ala Glu Ala Leu Glu Arg Arg Pro Gly     7775 7780 7785 Leu Arg Pro Ala Asp Val Gly Leu Ser Leu Ala Thr Gly Arg Thr     7790 7795 7800 Leu Phe Asp His Arg Ala Ala Val Leu Ala Ala Asp Arg Glu Glu     7805 7810 7815 Ala Leu Arg Gly Leu Thr Ala Leu Ala Ala Asp Leu Pro Asp Pro     7820 7825 7830 Ala Val Val Thr Gly Ala Val Arg Ser Gly Arg Thr Ala Val Leu     7835 7840 7845 Phe Ser Gly Gln Gly Ser Gln Arg Pro Gly Met Gly Arg Glu Leu     7850 7855 7860 His Asp Arg Phe Pro Val Phe Ala Glu Ala Phe Asp Ala Val Met     7865 7870 7875 Ala Ala Leu Glu Ala Glu Leu Gly Ser Asp Leu Arg Pro Val Val     7880 7885 7890 Trp Gly Ser Asp Thr Lys Pro Leu Asp Glu Thr Gly Ala Ala Gln     7895 7900 7905 Pro Ala Leu Phe Ala Val Glu Val Ala Leu Phe Arg Leu Val Glu     7910 7915 7920 Ser Trp Gly Ile Thr Pro Asp Val Leu Ala Gly His Ser Ile Gly     7925 7930 7935 Glu Ile Ala Ala Ala His Val Ala Gly Val Phe Ser Leu Ala Asp     7940 7945 7950 Ala Ala Arg Leu Val Ala Ala Arg Ala Ser Leu Met Gln Ala Leu     7955 7960 7965 Pro Ala Gly Gly Ala Met Ile Ala Val Arg Ala Thr Glu Asp Asp     7970 7975 7980 Val Ala Pro Tyr Val Thr Asp Arg Leu Ser Ile Ala Ala Val Asn     7985 7990 7995 Gly Pro Glu Ser Val Val Val Ser Gly Asp Glu His Ala Val Arg     8000 8005 8010 Glu Val Ala Ala Arg Phe Thr Ala Asp Gly His Arg Ala Thr Ala     8015 8020 8025 Leu Arg Val Ser His Ala Phe His Ser Pro Leu Met Asp Pro Met     8030 8035 8040 Leu Ser Glu Phe Gly Ala Val Ala Ala Gly Ile Thr Tyr Arg Glu     8045 8050 8055 Pro Ser Ile Pro Val Val Ser Asn Val Thr Gly Ala Leu Ala Gly     8060 8065 8070 Pro Gly Glu Leu Cys Asp Pro Gly Tyr Trp Val Arg His Val Arg     8075 8080 8085 Glu Thr Val Arg Phe Ala Asp Gly Val Thr Ala Leu Gln Gly Ala     8090 8095 8100 Gly Val Gly Thr Phe Leu Glu Leu Gly Pro Asp Gly Val Leu Ser     8105 8110 8115 Ala Leu Val Ser Ser Gln Thr Ala Asp Gly Val Val Val Pro Leu     8120 8125 8130 Leu Arg Lys Asp Arg Pro Glu Pro Gly Ala Ala Leu Ala Ala Leu     8135 8140 8145 Ala Arg Leu His Thr Ala Gly Thr Asp Val Asp Trp Pro Ala Leu     8150 8155 8160 Leu Thr Gly Gly Arg Arg Val Glu Leu Pro Thr Tyr Ala Phe Gln     8165 8170 8175 Arg Glu Arg Tyr Trp Pro Ala Gly Pro Leu Gly Gly Thr Ala Asp     8180 8185 8190 Leu Arg Ala Val Gly Leu Gly Ala Ala Gly His Pro Leu Leu Gly     8195 8200 8205 Ala Ala Val Gly Leu Ala Ala Asp Asp Gly Cys Leu Phe Thr Gly     8210 8215 8220 Arg Met Ser Leu Arg Thr His Pro Trp Leu Ala Asp His Thr Val     8225 8230 8235 Ala Gly Arg Val Val Val Pro Gly Thr Ala Leu Leu Glu Met Ala     8240 8245 8250 Val Arg Ala Gly Asp Glu Val Gly Cys Asp Arg Val Asp Glu Leu     8255 8260 8265 Thr Leu Gly Ala Pro Leu Val Leu Pro Thr Ser Gly Ser Val Gln     8270 8275 8280 Val Gln Val Ala Val Glu Ala Pro Asp Glu Ala Gly Arg Arg Thr     8285 8290 8295 Val Gly Val Trp Ser Arg Ser Gly Asp Asp Gly Thr Trp Thr Arg     8300 8305 8310 His Ala Thr Gly Ala Leu Ser Thr Ala Gly Ser Pro Ala Val Gly     8315 8320 8325 Glu Val Thr Thr Glu Trp Pro Pro Ala Gly Ala Glu Pro Val Glu     8330 8335 8340 Val Gln Gly Cys Tyr Asp Ala Phe Ala Asp Ala Gly Phe Gly Tyr     8345 8350 8355 Gly Pro Val Phe Arg Gly Leu Arg Ala Ala Trp Arg Arg Gly Glu     8360 8365 8370 Glu Leu Phe Ala Glu Val Ala Leu Pro Glu Glu Thr Ala Gly Ser     8375 8380 8385 Ala Asp Ala Phe Gly Leu His Pro Ala Leu Leu Asp Ala Ala Leu     8390 8395 8400 His Thr Ser Leu Leu Thr Gly Leu Gly Asp Gly Gly Thr Ala Ala     8405 8410 8415 Leu Pro Phe Ser Trp Gln Gly Val Ser Leu His Arg Ser Gly Ala     8420 8425 8430 Thr Ala Leu Arg Val Arg Leu Ala Pro Ser Gly Ala Asp Ala Met     8435 8440 8445 Ser Val Arg Ala Ser Asp Pro Ala Gly Ala Pro Val Val Thr Val     8450 8455 8460 Asp Ser Leu Val Thr Arg Ala Val Ala Ala Asp Ala Ala Thr His     8465 8470 8475 Gly Val Gly Asp Ala Leu Phe Glu Val Thr Arg Gln Pro Val Ala     8480 8485 8490 Ala Thr Gly Ala Pro Arg Thr Val Ala Val Leu Gly Glu Asp Pro     8495 8500 8505 Leu Gly Leu Ala Gly Pro Leu Ala Asp Ala Gly Val Pro Val Gly     8510 8515 8520 Thr Gly Thr Asp Val Ala Val Ile Ala Ala Arg Asp Glu Val Pro     8525 8530 8535 Glu Val Val Val Leu Gly Val Asp Gly Ala Gly Asp Pro Val Ser     8540 8545 8550 Gly Thr His Arg Thr Thr Ala Glu Val Leu Gly Thr Leu Gln Glu     8555 8560 8565 Trp Leu Arg His Asp Ala Leu Ala Gly Ser Arg Leu Val Val Val     8570 8575 8580 Thr Arg Gly Ala Thr Asp Gly Ser Asp Leu Ala Ala Ala Ala Val     8585 8590 8595 Ala Gly Leu Val Arg Ser Ala Gln Thr Glu His Pro Gly Ala Val     8600 8605 8610 Gly His Leu Asp Leu Gly Gly Asp Gly Thr Val Asp Ala Asp Ala     8615 8620 8625 Leu Ala Ser Ala Leu Gly Ser Asp Glu Pro Ala Leu Thr Leu Ser     8630 8635 8640 Gly Ala Glu Ile Arg Ala Pro Arg Leu Thr Arg Leu Pro Val Gly     8645 8650 8655 Gly Asp Pro Ala Val Trp Asn Pro Asp Gly Thr Val Leu Val Thr     8660 8665 8670 Gly Gly Thr Gly Gly Leu Gly Ala Gln Leu Ala Arg His Leu Val     8675 8680 8685 Glu Val His Gly Val Arg His Leu Val Leu Ala Ser Arg Arg Gly     8690 8695 8700 Ala Asp Ala Pro Gly Ser Ala Val Leu Val Asp Glu Leu Thr Ala     8705 8710 8715 Arg Gly Ala Ser Val Ser Val Arg Val Cys Asp Val Ser Asp Pro     8720 8725 8730 Ala Ala Val Thr Ala Leu Val Ala Asp Ala Gly Ala Asp Arg Ser     8735 8740 8745 Leu Thr Ala Val Val His Thr Ala Gly Val Leu Asp Asp Gly Val     8750 8755 8760 Leu Ala Ser Leu Thr Ala Glu Arg Leu Gly Thr Val Leu Ala Pro     8765 8770 8775 Lys Ala Asp Ala Ala Trp Tyr Leu His Glu Ala Thr Arg His Leu     8780 8785 8790 Asp Leu Asp Ala Phe Val Val Phe Ser Ser Val Ala Gly Val Leu     8795 8800 8805 Gly Gly Ala Gly Gln Ala Asn Tyr Ala Ala Gly Asn Ala Phe Leu     8810 8815 8820 Asp Ala Leu Ala Ala His Arg Arg Ala Ala Gly Leu Pro Gly Leu     8825 8830 8835 Ser Leu Ala Trp Gly Pro Trp Glu Gln Gly Ser Gly Met Thr Gly     8840 8845 8850 Thr Leu Asp Asp Ala Glu Ala Ala Arg Leu Ala Arg Ser Gly Met     8855 8860 8865 Pro Pro Leu Ser Ala Gln Asp Gly Leu Ser Leu Phe Asp Ala Ala     8870 8875 8880 Leu Ala Val Ser Gly Thr Ala Asp Gly Pro Ser Leu Val Ala Pro     8885 8890 8895 Val Arg Leu Asp Thr Ala Ala Leu Ala Glu Ser Gly Glu Val Pro     8900 8905 8910 Ala Ile Leu Arg Gly Leu Val Arg Thr Arg Thr Arg Arg Ala Ala     8915 8920 8925 Ala Gly Gly Ala Ala Thr Val Ala Gly Leu Val Asp Arg Leu Val     8930 8935 8940 Ala Leu Gly Pro Asp Val Arg His Arg Glu Leu Leu Asp Leu Val     8945 8950 8955 Arg Thr Arg Ile Ala Met Val Leu Gly His Ala Asp Pro Ala Val     8960 8965 8970 Val Asp Glu Arg Ala Pro Leu Arg Asp Leu Gly Phe Asp Ser Leu     8975 8980 8985 Thr Ala Val Glu Leu Arg Asn Arg Leu Ser Thr Ala Thr Gly Leu     8990 8995 9000 Arg Leu Thr Ala Thr Leu Val Phe Asp His Pro Thr Ala Thr Ala     9005 9010 9015 Leu Ala Glu His Leu His Glu Glu Leu Phe Gly Ala Asp Gly Val     9020 9025 9030 Val Pro Ala Pro Val Ala Ala Pro Ala Ala Val Ala Asp Asp Pro     9035 9040 9045 Val Val Val Val Gly Met Ala Cys Arg Phe Pro Gly Gly Val Ser     9050 9055 9060 Ser Pro Glu Asp Leu Trp Arg Leu Leu Asp Asp Gly Val Asp Ala     9065 9070 9075 Val Ser Gly Phe Pro Thr Asn Arg Asn Trp Asp Leu Gly Ser Val     9080 9085 9090 Tyr Asp Pro Asp Pro Asp His Ile Gly Thr Ser Ser Thr Arg His     9095 9100 9105 Gly Gly Phe Leu His Asp Ala Gly Gly Phe Asp Ala Gly Phe Phe     9110 9115 9120 Gly Met Ser Pro Arg Glu Ala Thr Ala Thr Asp Ala Gln Gln Arg     9125 9130 9135 Leu Leu Leu Glu Thr Ser Trp Glu Ala Val Glu Arg Ala Gly Ile     9140 9145 9150 Asp Pro Val Ser Leu Arg Gly Ser Ala Thr Gly Val Phe Ala Gly     9155 9160 9165 Val Met Tyr Ser Asp Tyr Gly Ser Ile Leu Gly Gly Arg Glu Phe     9170 9175 9180 Glu Gly Leu Gln Gly Gln Gly Ser Ser Pro Ser Val Ala Ser Gly     9185 9190 9195 Arg Val Ser Tyr Thr Leu Gly Leu Glu Gly Pro Ala Val Thr Val     9200 9205 9210 Asp Thr Ala Cys Ser Ser Ser Leu Val Gly Met His Leu Ala Ala     9215 9220 9225 Gln Ala Leu Arg Ala Gly Glu Cys Thr Leu Ala Leu Ala Gly Gly     9230 9235 9240 Val Thr Val Met Ser Thr Pro Gly Thr Phe Val Glu Phe Ser Arg     9245 9250 9255 Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp     9260 9265 9270 Ala Ala Asp Gly Val Gly Trp Ser Glu Gly Val Gly Met Leu Val     9275 9280 9285 Leu Glu Arg Arg Ser Asp Ala Leu Arg Asn Gly His Glu Ile Leu     9290 9295 9300 Ala Val Leu Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn     9305 9310 9315 Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg     9320 9325 9330 Arg Ala Leu Ala Asn Ala Gly Leu Gly Val Gly Asp Val Asp Val     9335 9340 9345 Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu     9350 9355 9360 Ala Gln Ala Leu Ile Ala Thr Tyr Gly Arg Asp Arg Asp Ile Asp     9365 9370 9375 Arg Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr     9380 9385 9390 Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Leu Ala     9395 9400 9405 Met Arg His Gly Thr Val Pro Arg Thr Leu His Val Asp Ala Pro     9410 9415 9420 Ser Ser His Val Asp Trp Ser Asp Gly Thr Val Ala Leu Leu Thr     9425 9430 9435 Glu Pro Thr Pro Trp Pro Glu Thr Gly Arg Ala Arg Arg Ala Gly     9440 9445 9450 Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Ile Val Leu     9455 9460 9465 Glu Gln Pro Val Ala Val Ala Glu Pro Gly Glu Pro Ala Glu Pro     9470 9475 9480 Glu Pro Arg Val Val Pro Trp Val Leu Ser Gly Arg Ser Pro Glu     9485 9490 9495 Ala Val Arg Ala Gln Ala Ala Arg Leu Arg Asp Ala Leu Thr Glu     9500 9505 9510 Gln Pro Gly Pro Arg Arg Val Asp Val Ala His Ala Leu Ala Thr     9515 9520 9525 Thr Arg Ser Glu Phe Ala His Arg Ala Val Val Leu Ala Gly Ala     9530 9535 9540 Gly Pro Asp Pro Leu Ala Ala Leu Asp Ala Val Ala Cys Gly Arg     9545 9550 9555 Pro Asp Pro Ala Ala Val Thr Gly Glu Ser Asp Gly Gly Arg Thr     9560 9565 9570 Ala Leu Leu Phe Ser Gly Gln Gly Ser Gln Arg Pro Gly Met Gly     9575 9580 9585 Arg Asp Leu Tyr Ala Arg Phe Pro Val Phe Ala Glu Ala Phe Asp     9590 9595 9600 Ala Val Val Ala Ala Leu Asp Ala Glu Leu Glu Pro Ala Asp Gly     9605 9610 9615 Gly Thr Leu Arg Glu Val Met Trp Ala Ala Asp Asn Gly Glu Ser     9620 9625 9630 Gly Arg Leu Asp Glu Thr Gly Trp Thr Gln Pro Ala Leu Phe Ala     9635 9640 9645 Val Glu Val Ala Ala His Arg Leu Val Glu Ser Trp Gly Val Arg     9650 9655 9660 Pro Asp Leu Val Ala Gly His Ser Ile Gly Glu Ile Ala Ala Ala     9665 9670 9675 His Val Ala Gly Val Phe Ser Leu Ala Asp Ala Ala Arg Leu Val     9680 9685 9690 Ala Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Thr Gly Gly Ala     9695 9700 9705 Met Ile Ala Val Gln Ala Arg Ala Asp Glu Val Thr Pro Leu Leu     9710 9715 9720 Thr Gly Asp Val Ala Ile Ala Ala Val Asn Gly Pro Ala Ser Val     9725 9730 9735 Val Val Ser Gly Thr Glu Asp Ala Val Leu Ala Val Gly Thr Arg     9740 9745 9750 Leu Ala Glu Gln Gly Arg Arg Thr Thr Arg Leu Gln Val Ser His     9755 9760 9765 Ala Phe His Ser Pro Leu Met Asp Pro Met Leu Glu Gly Phe Arg     9770 9775 9780 Ala Val Ala Glu Arg Leu Thr Tyr Ala Glu Pro Val Val Pro Val     9785 9790 9795 Val Ser Asn Leu Thr Gly Ala Leu Ala Arg Pro Gly Gln Leu Cys     9800 9805 9810 Asp Pro Glu Tyr Trp Val Arg His Val Arg Glu Thr Val Arg Phe     9815 9820 9825 Ala Asp Gly Leu Ala Ser Leu Asp Ala Ala Gly Val Thr Ala Tyr     9830 9835 9840 Leu Glu Ile Gly Pro Asp Gly Val Leu Ser Ala Leu Ala Ala Gln     9845 9850 9855 Thr Val Pro Glu Gly Ala Val Thr Val Pro Leu Leu Arg Arg Asp     9860 9865 9870 Arg Asp Glu Glu Thr Thr Ala Leu Thr Ala Arg Ala Gln Leu His     9875 9880 9885 Ala Ala Gly Arg Thr Gly Gly Trp His Asp Leu Phe Thr Gly Thr     9890 9895 9900 Arg Pro Ala Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln His Gln     9905 9910 9915 Trp Phe Trp Pro Ala Ala Arg Thr Ala Asp Gly Asp Val Arg Ala     9920 9925 9930 Ala Gly Leu Gly Ala Pro Glu His Pro Leu Leu Gly Ala Ala Val     9935 9940 9945 Glu Leu Ala Ser Gly Gly Gly Val Val Phe Thr Gly Arg Leu Ser     9950 9955 9960 Arg Gly Ser His Pro Trp Leu Val Asp His Thr Val Leu Gly His     9965 9970 9975 Val Leu Val Pro Gly Thr Ala Leu Leu Asp Met Ala Ile Arg Ala     9980 9985 9990 Gly Asp Gln Val Gly Cys Asp Arg Val Glu Glu Leu Thr Leu Ala     9995 10000 10005 Ala Pro Leu Ala Leu Pro Glu Gln Gly Ala Leu Gln Leu Gln Val     10010 10015 10020 Thr Val Asp Ala Pro Asp Pro Asp Gly Asn Arg Ala Ile Gly Ile     10025 10030 10035 His Ser Arg Pro Glu Gly Ala Gly Glu Asp Ala Trp Thr Arg His     10040 10045 10050 Ala Ala Gly Ala Leu Ala Pro Ala Gly Pro Ala Ala Pro Leu Gly     10055 10060 10065 Ala Asp Ala Ala Val Trp Pro Pro Pro Asp Ala Val Glu Ile Asp     10070 10075 10080 Thr Glu Gly Cys Tyr Asp Thr Phe Ala Asp Ala Gly Phe Val Tyr     10085 10090 10095 Gly Pro Val Phe Arg Gly Leu Arg Ala Ala Trp Arg Arg Gly Glu     10100 10105 10110 Glu Leu Phe Ala Glu Val Glu Leu Pro Asp Gly Ala Gly Gly Thr     10115 10120 10125 Asp Gly Phe Gly Leu His Pro Ala Leu Leu Asp Ala Ala Leu His     10130 10135 10140 Val Ser Leu Leu Ala Ala Leu Ala Ser Asp Gly Thr Gly Gly Thr     10145 10150 10155 Gly Gly Gly Ala Leu Pro Phe Ser Trp Ser Gly Val Ser Leu Met     10160 10165 10170 Ala Gly Gly Ala Ala Ala Leu Arg Val Arg Ile Ala Pro Ser Ala     10175 10180 10185 Asp Gly Val Leu Ser Val Arg Ala Val Asp Gly Ala Gly Ala Pro     10190 10195 10200 Val Val Thr Val Glu Ala Leu His Thr Arg Gln Val Gly Ala Glu     10205 10210 10215 Gln Leu Arg Ala Ala Arg Thr Asp Arg Asp Ala Leu Phe Gly Leu     10220 10225 10230 Asp Trp Thr Val Val Asp Ala Ala Glu Gly Ala Ala Pro Val Val     10235 10240 10245 Ala Val Leu Gly Ala Asp Pro Phe Gly Leu Ala Gly Ala Val Pro     10250 10255 10260 Asp Ala Val Gln Val Asp Asp Leu Ala Thr Leu Val Ser Ala Thr     10265 10270 10275 Asp Pro Val Pro Asp Val Val Leu Phe Pro Val Ala Ala Glu Pro     10280 10285 10290 Gly Val Thr Gly Arg Pro Glu Glu Val Arg Ala Cys Thr Val Arg     10295 10300 10305 Val Leu Glu Gln Leu Gln Arg Trp Leu Ala Thr Glu Glu Leu Ala     10310 10315 10320 Thr Ala Arg Leu Val Val Val Thr Arg Gly Ala Val Thr Val Asp     10325 10330 10335 Asp Gly Gly Val Gly Asp Leu Pro Ala Ala Ala Val Arg Gly Leu     10340 10345 10350 Val Arg Ser Ala Ser His Glu Asn Pro Gly Thr Phe Gly Leu Leu     10355 10360 10365 Asp Leu Asp Pro Asp Ala Ala Gly Thr Asp Phe Ser Gly Leu Ala     10370 10375 10380 Ala Ala Leu Thr Ala Leu Ala Thr Glu Pro Glu Leu Ala Val Arg     10385 10390 10395 Asp Gly Ala Leu Arg Ala Pro Arg Leu Ala Arg Ile Ala Ala Thr     10400 10405 10410 His Glu Gln Pro Asp Gly Ser Asp Ala Arg Pro Ala Leu Arg Thr     10415 10420 10425 Asp Gly Thr Val Leu Val Thr Gly Gly Thr Gly Gly Leu Gly Ser     10430 10435 10440 Leu Val Ala Arg His Leu Val Thr Gly Arg Gly Val Arg Asp Leu     10445 10450 10455 Val Leu Ala Gly Arg Arg Gly Pro Ser Ala Pro Gly Ala Ala Glu     10460 10465 10470 Leu Val Ala Asp Leu Glu Ala Leu Gly Ala Arg Val Arg Val Val     10475 10480 10485 Ala Cys Asp Val Ala Asp Arg Asp Ala Val Ala Ala Leu Val Ala     10490 10495 10500 Glu Ala Gly Arg Glu Arg Pro Leu Arg Gly Val Val His Thr Ala     10505 10510 10515 Gly Val Leu Asp Asp Gly Val Leu Gly Ser Leu Asp Ala Ala Arg     10520 10525 10530 Leu Asp Thr Val Leu Arg Pro Lys Ala Asp Ala Ala Trp His Leu     10535 10540 10545 His Glu Ala Thr Arg Asp Leu Asp Leu Asp Ala Phe Val Leu Phe     10550 10555 10560 Ser Ser Val Ala Gly Val Leu Gly Gly Ala Gly Gln Ala Asn Tyr     10565 10570 10575 Ala Ala Gly Asn Ala Tyr Leu Asp Ala Leu Ala Ala Ser Arg Arg     10580 10585 10590 Ala Asp Gly Leu Ala Gly Leu Ser Met Ala Trp Gly Pro Trp Glu     10595 10600 10605 Gln Gly Ser Gly Met Thr Gly Thr Leu Gly Glu Ala Glu Ala Gln     10610 10615 10620 Arg Leu Ala Arg Ser Gly Met Pro Pro Leu Pro Ala Glu Gln Gly     10625 10630 10635 Leu Glu Leu Phe Asp Thr Leu Leu Ala Ala Gly Ser Thr Gly Arg     10640 10645 10650 Ala Leu Val Leu Pro Val Arg Leu Asp Leu Ala Ala Leu Arg Ala     10655 10660 10665 Leu Asp Glu Val Pro Ala Leu Leu Arg Gly Leu Val Arg Thr Thr     10670 10675 10680 Pro Arg Arg Thr Ala Ala Ala Gly Thr Ala Pro Asp Ala Asp Ala     10685 10690 10695 Leu Val Arg Arg Leu Ala Gly Leu Gly Ala Pro Glu Gln Asp Glu     10700 10705 10710 Ile Leu Leu Ala Leu Val Arg Gly Ala Ala Asp Val Leu Gly     10715 10720 10725 His Thr Asp Ala Thr Ala Val Gly Val Arg Gln Gln Phe Gln Glu     10730 10735 10740 Leu Gly Phe Asp Ser Leu Thr Ala Val Glu Tyr Arg Asn Arg Leu     10745 10750 10755 Asn Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Leu Phe Asp     10760 10765 10770 Phe Pro Thr Pro Ala Glu Val Val Arg His Leu Arg Ser Arg Leu     10775 10780 10785 Val Val Ala Glu Pro Ala Gly Ala Asp Ala Val Leu Ala Ala Leu     10790 10795 10800 Asp Gly Leu Glu Arg Ala Ile Ala Gly Leu His Val Asp Asp Glu     10805 10810 10815 Gly Glu His Arg Arg Val Ala Gly Arg Ile Glu Val Leu Arg Thr     10820 10825 10830 Lys Trp Ala Gly Leu His Ala Glu Asp Arg Pro Ser Asp Pro Asp     10835 10840 10845 Gly Asp Gly Ala Gly Asp Asp Thr Leu Asp Asp Ala Ser Asp Asp     10850 10855 10860 Asp Met Phe Ala Leu Leu Asn Asp Glu Leu Gly Leu Gly     10865 10870 10875 <210> 16 <211> 274 <212> PRT <213> Pseudonocardia autotrophica <400> 16 Met Pro Val His Trp Leu Arg Arg Pro Ala Ala Arg Arg Val Arg Pro 1 5 10 15 Arg Gly Arg Asn Pro Met Thr Thr Thr Ala Thr Glu Glu Ser Leu Trp             20 25 30 Val Arg Cys Phe His Pro Ala Pro Glu Arg Pro Val Gln Leu Val Cys         35 40 45 Phe Pro His Ala Gly Gly Ser Ala Ser Phe Tyr Phe Pro Val Ser Ala     50 55 60 Gln Leu Gln Thr Thr Ala Glu Val Phe Ala Val Gln Tyr Pro Gly Arg 65 70 75 80 Gln Asp Arg Arg Arg Glu Thr Ser Pro Gly Asp Leu His Thr Leu Ala                 85 90 95 Asp Gln Val His Gly Ala Leu Arg Asp Ser Leu Arg Gly His Arg Pro             100 105 110 Thr Val Phe Phe Gly His Ser Met Gly Ala Thr Leu Ala Phe Glu Val         115 120 125 Ala Arg Arg His Glu Ala Gln Gly Gly Arg Ile Ala His Leu Phe Ala     130 135 140 Ser Gly Arg Arg Ala Pro Ser Arg Val Arg Asp Glu His Val His Arg 145 150 155 160 Leu Ser Asp Glu Gln Ile Val Glu Glu Leu Lys Leu Leu Ala Gly Thr                 165 170 175 Asp Thr Ala Leu Leu Gly Asp Asp Glu Ile Leu Arg Met Ile Leu Pro             180 185 190 Ala Ile Arg Ser Asp Tyr Glu Ala Ile Glu Thr Tyr Arg Cys Thr Pro         195 200 205 Gly Ala Thr Val Ala Ala Pro Ile Thr Val Leu Thr Gly Asp Ser Asp     210 215 220 Pro Lys Thr Ser Arg Asp Glu Ala Glu Ser Trp Arg Asp His Thr Ser 225 230 235 240 Gly Pro Phe Asp Leu His Val Arg Pro Gly Gly His Phe Phe Leu Gly                 245 250 255 Ser Asp Ala Pro Ala Ile Ile Ala Met Leu Arg Thr Val Leu Thr Ala             260 265 270 Ser Ser          <210> 17 <211> 946 <212> PRT <213> Pseudonocardia autotrophica <400> 17 Met Ser Asp Ala Thr Asp Arg Gly Val Arg Leu Val Gly Arg Gly Ser 1 5 10 15 Glu Ser Ala Trp Leu Ala Ser Ala Gly Ala Gly Ala Ala Ala Gly Ser             20 25 30 His Val Val Arg Leu Leu Val Gly Pro Pro Gly Ile Gly Lys Ser Val         35 40 45 Leu Leu Asp Gly Phe Cys Thr Glu Val Pro Ala Gly Val Arg Ala Ala     50 55 60 Arg Ala His Gly Arg Glu Arg Thr Ser Asp Ile Ser Phe Ala Val Val 65 70 75 80 Arg Glu Leu Phe Gly Ala Leu Ala Gly Ala Gly Pro Val Asp Pro Ala                 85 90 95 Leu Leu Glu Gly Gly Ala Arg Trp Ser Ala Pro Ala Leu Asp Glu Ala             100 105 110 Thr Gly Gly Ala Gly Pro Asp Asn Leu Tyr Pro Val Leu His Gly Leu         115 120 125 Tyr Trp Leu Thr Val Asn His Thr Ala Arg Gly Pro Leu Val Leu Val     130 135 140 Val Asp Asp Leu Gln Trp Cys Asp Asp Ala Ser Leu Ala Phe Leu Gly 145 150 155 160 Phe Leu Leu Arg Arg Ser Glu Gly Leu Pro Leu Gly Val Val Leu Ala                 165 170 175 Ser Arg Thr Asp Gly Ala Gly Ala Leu Pro Asp Arg Leu Ala Glu Ile             180 185 190 Arg Thr Gln Ala Gly Ala Ala Val Thr Glu Val Gly Pro Leu Asp Arg         195 200 205 Ser Gly Val Ala Arg Leu Ala Val Ala Arg Gly Ala Gly Thr Gly Ala     210 215 220 Glu Pro Pro Gln Ala Pro Leu Leu Asp Ala Leu Thr Glu Ala Ser Gly 225 230 235 240 Gly Asn Pro Leu Leu Val Glu Gln Leu Val Ala Glu Leu Gly Pro Val                 245 250 255 Thr Gly Asp Gly Ala Thr Asp Arg Ile His Arg Leu Gly Arg Glu Val             260 265 270 Val Asp Gly Leu Val Glu Arg His Val Phe Asp Ala Pro Pro His Val         275 280 285 Arg Ala Val Ala Ala Ala Val Ala Val Val Gly Ala Glu Gln Thr Thr     290 295 300 Val Leu Ala Thr Leu Ser Gly Val Pro Ala Gly Ser Val Ala Asp Ala 305 310 315 320 Val Ala Thr Leu Val Arg Thr Glu Val Phe Ala Pro Asp Arg Ser Asp                 325 330 335 Phe Arg His Asp Leu Leu Arg Thr Ala Val Leu Arg Gly Leu Pro Gly             340 345 350 Asp Glu Leu Asp Asp Leu Arg Arg Arg Gly Ala Arg Val Leu Ser Asp         355 360 365 Ala Gly Arg Pro Ala Glu Val Val Ala Ala Val Leu Leu Val Leu Pro     370 375 380 Gly Ala Gly Glu Pro Trp Met Val Asp Val Leu Leu Glu Ala Ala Ala 385 390 395 400 Ala Ala Ala His Arg Gly Ala Arg Pro Ala Val Ala Arg Tyr Leu Glu                 405 410 415 Pro Val Val Ala Ala Arg Pro Asp Asp Val Gly Ala Arg Thr Arg Leu             420 425 430 Ala Ala Ala Leu Ala Gln His Glu Pro Glu Arg Ala Val Ala Gln Leu         435 440 445 Arg Asp Ala Leu Asp Arg Ala Val Asp Leu Pro Ser Arg Ala Gln Ala     450 455 460 Ala Val Gln Leu Ala Met Thr Ser Leu Ala Val Gln Gln Ala Pro Arg 465 470 475 480 Ala Val Arg Val Leu Gln Asp Val Leu Asp Thr Met Asp Arg Glu Phe                 485 490 495 Pro Ala Asp Pro Gly Pro Glu Ala Thr Glu Leu Arg Thr His Val Glu             500 505 510 Ala Ala Leu Leu Val Val Gly Leu Asp Glu Lys Lys Thr Val Ala Ala         515 520 525 Thr Ile Asp Arg Met Gly Arg Met Ala Arg Pro Ala Gly Arg Thr Pro     530 535 540 Ala Glu Arg Gln Lys Leu Ala Met Met Thr Val Thr Leu Ala Met Asp 545 550 555 560 Gly Asp Asp Ala Ala Ala Ala Val Asp Leu Ala Arg Arg Val Leu Leu                 565 570 575 Val Asp Glu Ala Thr Leu Gly Gly Trp Ala Val Leu Ala Ser Ser Leu             580 585 590 Val Leu Arg Leu Ala Asp Glu Val Glu Glu Ser Thr Ala Val Leu Asp         595 600 605 Arg Leu Val Val Gln Ser Arg Glu Gln Ala Ser Ala Trp Thr Tyr Ser     610 615 620 Leu Ala Val Gly Thr Arg Ala Thr Asn His Val Val Val Gly Ser Leu 625 630 635 640 Ala Glu Gly Glu Ala Asp Ala Arg Thr Ala Leu Asp Ile Ala Glu Gln                 645 650 655 Glu Ala Trp Arg Gly Asn Thr Val Val Pro Thr Ile Ala Leu Ala Asn             660 665 670 Val Arg Gln Gln Gln Gly Asp Pro Glu Ala Ala Leu Glu Leu Leu Asp         675 680 685 Gly Ile Val Arg Pro Arg Leu Glu Asp Phe Ala Trp Glu Tyr His Asp     690 695 700 Tyr Leu Met Ala Arg Ala Gly Ala Thr Ala Asp Val Gly Asp Val Asp 705 710 715 720 Arg Ala Leu Ser Thr Tyr Arg Arg Cys Gly Asp Ser Leu Asp Ala Ala                 725 730 735 Gly Ile Ala Asn Pro Val Leu Ala Pro Trp Trp Val His Ala Ala Val             740 745 750 Leu Leu Ala Asp Thr Gly Arg Ala His Glu Ala His Gly Ile Val Glu         755 760 765 Gly Gly Ala Glu Arg Ala Ala Arg Trp Gly Thr Gly Arg Gly Arg Gly     770 775 780 Leu Ala Leu Leu Ala Arg Gly Val Val Thr Ala Gly Pro Arg Gly Glu 785 790 795 800 Asp Met Leu Arg Glu Ala Val Glu Val Leu Glu Gly Ser Pro Ala Arg                 805 810 815 Thr Glu Leu Ile Leu Ala His His Leu Leu Gly Arg Ala Met Leu Val             820 825 830 Ser Asp His Ala Glu Asp Ala Arg Glu Gln Leu Arg Arg Ala Ala Thr         835 840 845 Leu Ala Ala Arg Cys Gly Ala Leu Arg Ala Ala Arg Val Ala Arg Glu     850 855 860 Leu Leu Val Gln Ala Gly Gly Arg Met Arg Pro Pro Thr Gly Ser Pro 865 870 875 880 Leu Asp Pro Leu Thr Gly Ala Glu Arg Arg Val Val Ala Leu Ala Ala                 885 890 895 Glu Gly Ala Arg Asn Arg Glu Ile Ala Glu Ala Leu Phe Val Thr Leu             900 905 910 Arg Thr Val Glu Val His Leu Thr Ser Ala Phe Arg Lys Leu Gly Val         915 920 925 Thr Asp Arg Ala Ala Leu Ala Gly Ile Val Asp Ala Ala Arg Val Arg     930 935 940 Ser ala 945 <210> 18 <211> 765 <212> PRT <213> Pseudonocardia autotrophica <400> 18 Met Leu Arg Glu Arg Asp Ala Ala Cys Ala Glu Leu Asp Arg Ala Leu 1 5 10 15 Asp Ala Leu Val Ala Gly Gly Ser Pro Phe Val Ala Ile Thr Gly Glu             20 25 30 Pro Gly Thr Gly Arg Ser Ala Leu Leu Arg Arg Ala Ser Gly Arg Ala         35 40 45 Ala Asp Arg Ala Val Arg Val Leu Ser Ala Arg Ala Val Pro Thr Glu     50 55 60 Thr Gly Cys Pro Leu Ala Thr Gly His Gly Leu Val Glu Arg Leu Gly 65 70 75 80 Pro Val Pro Ala Pro Pro Arg Ser Gly Pro Val Gly Ala Asp Val Leu                 85 90 95 His Glu Trp Cys Arg Ala Val Leu Asp Leu Ala Arg Thr Gly Pro Val             100 105 110 Leu Leu Val Val Asp Asp Leu His Trp Ala Asp Glu Asp Thr Gly Gln         115 120 125 Trp Leu Gln Met Leu Leu Arg Arg Arg Arg Glu Ala Pro Val Gly Leu     130 135 140 Leu Val Ala Leu Asn Gly Thr His Asp Gly Leu Gly Trp Ala Val Ser 145 150 155 160 Pro Thr Gly Pro Ser Asp Val Val Leu Arg Thr Gly Pro Leu Ser Leu                 165 170 175 Gly Ala Val Arg Glu Val Val Thr Ala Glu Tyr Pro Thr Pro Pro Asp             180 185 190 Arg Ala Phe Thr Val Leu Ala Arg Arg Cys Thr Gly Gly Asn Pro Ala         195 200 205 Val Leu Arg Ala Thr Leu Ala Gly Leu Asp Arg Ala Val Pro Pro Thr     210 215 220 Ala Ala Ala Val Pro Glu Leu Val Arg Arg Ala Ala Thr Ala Arg Arg 225 230 235 240 Asp His Val Ala Arg Val Leu Asp Gly Leu Pro Pro Ala Leu Val Glu                 245 250 255 Ala Leu Arg Ala Ala Ala Val Cys Gly Ser Glu Leu Gln Pro Val Arg             260 265 270 His Arg Val Gly Gly Pro Val Ala Ser Thr Gly Ala Gly Ala Arg Ala         275 280 285 Ala Leu Ala Ala Thr Gly Leu Val Arg Gly Thr Asp His Ala Leu Pro     290 295 300 Ala Asp Arg Ser Val Thr Asp Val Val Leu Ala Gly Ile Glu Pro Gly 305 310 315 320 His Arg Arg Ala Leu Phe Gly Ser Ala Ala Gly Leu Ala Ala Arg Ala                 325 330 335 Gly Leu Pro Glu Glu Arg Ile Ala Arg Ala Leu Leu Asp Ala Pro Ala             340 345 350 Leu Gly Glu Pro Trp Ala Ala Glu Leu Leu His Arg Val Ala Val Arg         355 360 365 His Arg Ala Glu Asp Arg Pro Ala Asp Ala Ala Ala Ala Ala Glu Arg     370 375 380 Ala Leu Gln Glu Pro Leu Pro Asp Pro Leu Arg Gly Ala Leu Leu Val 385 390 395 400 Glu Leu Ala Leu Ser Arg Ser His Thr Ala Pro Gly Thr Ala Ala Arg                 405 410 415 Val Leu Ser Arg Ile Thr Leu Asp Thr Asp Pro Ala Ala Ser Arg Tyr             420 425 430 Gly Ala Arg Ala Val Asp Leu Leu Leu Ser Ala Gly Glu Val Gly Ala         435 440 445 Ala Arg Gln Ala Leu Asp Ile Ala Val Arg Arg Cys Pro Glu Asp Ala     450 455 460 Pro Ala Arg Ala Asp Leu Leu Ser Leu Ser Arg Leu Thr Asp Glu Leu 465 470 475 480 Gly Phe Asp Arg Arg Thr Val Leu His Gly Pro Val Ala Thr Ala Ala                 485 490 495 Ala Gly Ser Asp Asp Asp Gly Pro Val Ala Arg Gly Thr Thr Ala Trp             500 505 510 Ser Leu Val Leu Arg Gly Arg Asp Arg Asp Arg Ala Thr Arg Leu Ala         515 520 525 Arg Ala Thr Leu Thr Gly Pro Ser Gly Val Leu Pro Ala Ile Pro Gln     530 535 540 Val Val Ala Ala Leu Thr Leu Asp Ala Val Gly Cys Ala Asp Glu Ala 545 550 555 560 Gly Glu Ala Met His His Leu Leu Leu Glu Ile Thr Arg Glu Arg Pro                 565 570 575 Val Pro Pro Ala Val Leu Ala Val Ser Ala Leu Val Glu Leu Arg Thr             580 585 590 Gly Asp Leu Asp Gly Ala Arg Arg Asp Leu Arg Ala Ala Ala Val Ala         595 600 605 Pro Val Ser Ser Asp Gly Pro Asp Pro Leu Ala Gly Ala Ala Arg Val     610 615 620 Leu Val His Leu Ala Glu Pro Asp Val Glu Ala Ala Asp Ala Ala Ala 625 630 635 640 Phe Ala Asp Leu Ala Ala Gly Gly Val Arg Pro Gly Ala Ala Leu Leu                 645 650 655 Glu Tyr Ala Arg Gly Arg Val Arg Ser Val Gln Gly Arg His Arg Asp             660 665 670 Ala Val Glu His Tyr Met Gly Cys Gly Arg Leu Leu Leu Asp Arg Gly         675 680 685 Arg Val Asn Pro Val Leu Ala Pro Trp Arg Ser Ala Ala Ala Thr Ser     690 695 700 Leu Leu Ala Cys Gly Ser Pro Ala Ala Ala Arg Arg Leu Ala Ala Asp 705 710 715 720 Glu Leu Arg Leu Ala Leu Arg Trp Gly Ala Pro Ala Pro Val Ala Ala                 725 730 735 Ala Glu Ala Val Leu Ala Gly Leu Asp Ala Glu Pro Thr Ala Val Gly             740 745 750 Glu Pro Leu Gly Asp Gly Val Ala Arg Ala Ala Arg Pro         755 760 765 <210> 19 <211> 925 <212> PRT <213> Pseudonocardia autotrophica <400> 19 Met Arg Asp Ala Val Thr Arg Ala Ala Asp Gly Ser Gly Ala Ala Val 1 5 10 15 Val Val Gly Gly Gly Val Gly Ser Gly Arg Thr Ala Leu Leu Asp Ala             20 25 30 Val Gly Val Ala Ala Gly Arg Ala Gly Leu Thr Val Leu Arg Ala Ala         35 40 45 Ser Ala Leu Val Glu Arg Asp Phe Glu Phe Gly Val Pro Arg Gln Leu     50 55 60 Phe Asp Pro Leu Leu Ala Ala Ala Gly Ala Asp Ala Arg Thr Arg Trp 65 70 75 80 Leu Ala Ala Ser Arg Pro Arg Leu Pro Ala Ala Leu Ala Ala Glu Pro                 85 90 95 Leu Asp Pro Ala Glu Thr His Glu Glu Gln Asp Arg Val Arg Glu Leu             100 105 110 Gln Ala Leu Leu Ala Thr Val Gly Ala Glu Arg Pro Val Leu Val Leu         115 120 125 Val Asp Asp Leu Gln Trp Ala Asp Thr Ala Ser Leu Arg Trp Leu Asn     130 135 140 Arg Leu Val Ala Arg Ile Pro Asp Leu Pro Val Ser Phe Val Gly Thr 145 150 155 160 Thr Leu His Gly Asp Pro Gly Ala Gly Arg Pro Pro Val Arg Gly Leu                 165 170 175 Ala Gly Ser Ala Val Pro Leu Arg Ser Arg Pro Leu Gly Pro Ala Ala             180 185 190 Val Arg Gly Met Val Ala Gly Arg Phe Gly Arg Ala Gly Asp Pro Glu         195 200 205 Phe Leu Gln Val Cys Glu Glu Val Ser Gly Gly Val Pro Ser Val Leu     210 215 220 Arg Ala Val Leu Asp Glu Val Val Ala Aly Gly Gly Gly Pro Val Ala 225 230 235 240 Ala Cys Ile Pro Ala Val Arg Ser Ala Arg Pro Ala Gly Leu Arg Glu                 245 250 255 Arg Phe Ala Arg Cys Leu Arg Ala Gln Asp Asp Ala Ala Arg Arg Tyr             260 265 270 Leu Gly Ala Leu Ala Val Leu Gly Pro Ala Ala Asp Pro Ala Val Val         275 280 285 Ala Arg Leu Ala Glu Leu Asp Pro His Gly Leu Arg Ala Val Gln Gly     290 295 300 Gln Leu Thr Glu Gln Gly Leu Leu Thr Asp Asp His Thr Gly Phe Thr 305 310 315 320 His Pro Leu Val Arg Asp Val Ala Ala Asp Pro Ala Glu Arg Glu Arg                 325 330 335 Leu His Leu Arg Ala Ala Arg Leu Leu His Glu Thr Gly His His Ala             340 345 350 Gln Glu Val Ala Ala His Leu Leu Ala Val Ala Ala Pro Leu Asp Gly         355 360 365 Trp Ala Val Glu Val Leu Arg Ala Ala Ala His Gln Thr Thr Thr Ala     370 375 380 Leu Arg Pro Asp Thr Ala Asp Asp His Asp Asp Asp Pro Val Ala Val 385 390 395 400 Arg Tyr Leu Arg Arg Ala Leu Leu Asp Ser Asp Val Arg Gly His Glu                 405 410 415 Arg Gly Ala Leu Leu Val Glu Leu Ala Ala Ala Glu Arg Phe Thr Glu             420 425 430 Pro Gly Thr Ala Val Arg His Val Ser Gln Ala Leu Pro Leu Leu Ala         435 440 445 Ser Pro Gln Asp Arg Ala Val Ala Leu Thr Leu Ile Asp Pro Ser Thr     450 455 460 Val Arg Glu Val Pro Ala Arg Val Gln Glu Ala Val Arg Ala Ala Asp 465 470 475 480 Ala Gly Thr Asp Pro Val Val Asp Asp Glu Cys Thr Val Ala Val Arg                 485 490 495 Ile Arg Ala Arg Ala Arg Arg Leu Asp Glu Gln His Pro Glu Gly Leu             500 505 510 Ala Arg Ser Cys Ala Leu Leu Arg Glu Val Val Ala Ala Pro Asp Glu         515 520 525 His Leu Ser Thr Ala Ala Gly Arg Glu Leu Val Gly Val Leu Leu His     530 535 540 Ala Ala Ala Leu Thr Gly Gly Val Pro Ala Ala Asp Val Ala His Leu 545 550 555 560 Gly Glu Arg Leu Leu Arg Ile Thr Pro Ala Arg Glu Val Arg Pro Pro                 565 570 575 His Gly Ile Pro Pro Gly Asp Gly Pro Arg Gly Leu Leu Val Leu Ala             580 585 590 Leu Val Ala Ala Asp Arg Pro Arg Pro Leu Glu Asp Trp Leu Val Pro         595 600 605 Asp Pro Thr Ser Pro Ala Ala Ala Thr Ala Asp Glu Leu Ala Leu Val     610 615 620 Leu Leu Ala Arg Gly Arg Pro Ala Ala Ala Ala Ala Leu Pro Gly Gly 625 630 635 640 Val Leu Arg Glu Arg Gly Val Pro Ala Ser Ala Ala Phe His Thr Ala                 645 650 655 Leu Ile Ala Ala Ala Ile Glu Ala Arg Ala Pro Ala Leu Gly Pro Glu             660 665 670 Pro Ala Gly Arg Pro Pro Gly Gly Gly Leu Val Ala His Ala Thr His         675 680 685 Gln Leu Val Arg Ala Ala Gly Ala Leu Arg Ala Gly Arg Gln Asp Leu     690 695 700 Ala Leu Glu Cys Leu Leu Asp Cys Gly Arg His Leu Glu His Leu Gly 705 710 715 720 Trp Ser Asn Pro Ala Leu Phe Pro Trp Arg Ser Trp Ala Ala Arg Leu                 725 730 735 Leu Arg Arg Arg Gly Ala Thr Gly Ala Ala Leu Glu Trp Ala Asp Glu             740 745 750 Glu Leu Ala Leu Ala Arg Ala Trp Gly Ala Pro Ala Ala Leu Gly Arg         755 760 765 Ala Leu Arg Val Arg Gly Ser Leu Val Gly Gly Ala Ala Gly Ala Thr     770 775 780 Gln Leu Arg Glu Ala Val Glu Val Leu Arg Asp Ser Ala Asp Thr Ala 785 790 795 800 Ala Leu Gly Arg Ala Glu Ile Val Leu Gly Arg His Leu Ala Gly Thr                 805 810 815 Gly Ala Pro Glu Gly Glu Ala Leu Leu Arg Arg Gly Leu Arg Arg Leu             820 825 830 Glu Glu Ala Gly Ala Gly Asp Pro Asp Thr Ala Thr Pro Val Pro Thr         835 840 845 Val Glu Pro Ala Ala Gly Thr Gly Asp Asp Gly Glu Glu Ser Pro Ala     850 855 860 Trp Arg Val Val Asp Ala Leu Thr Asp Ala Glu Arg Gln Val Val Asp 865 870 875 880 Arg Val Val Gly Gly Ala Thr Asn Lys Met Ile Ala Glu Glu Leu Gly                 885 890 895 Val Ser Arg Arg Ala Val Glu Lys Arg Leu Thr Ser Ala Tyr Arg Lys             900 905 910 Leu Gly Val Ser Gly Arg Ser Ala Leu Arg Gly Ala Asp         915 920 925 <210> 20 <211> 526 <212> PRT <213> Pseudonocardia autotrophica <400> 20 Met Thr Ala Thr Asp Asp Ile Arg Thr Thr Ala Asp Leu Arg Ser Arg 1 5 10 15 Val Ala Glu Leu His Ala Ala Arg Glu Gln Ile Arg Ser Gly Pro Ser             20 25 30 Thr Ala Ala Thr Glu Gln Gln His Ala Arg Gly Lys Leu Thr Val His         35 40 45 Glu Arg Leu Ala Met Leu Leu Asp Glu Gly Ser Phe Arg Glu Ile Glu     50 55 60 Gln Phe Arg Arg His Arg Ala Thr Gly Phe Gly Leu Glu Asp Arg Arg 65 70 75 80 Pro His Thr Asp Gly Val Val Thr Gly Trp Gly Thr Ile Asp Gly Arg                 85 90 95 Thr Val Phe Val Tyr Ala His Asp Phe Arg Ile Phe Gly Gly Ser Leu             100 105 110 Gly Glu Ala His Ala Thr Lys Ile His Lys Val Met Asp Leu Ala Glu         115 120 125 Ser Ala Gly Ala Pro Leu Ile Ser Leu Ser Asp Gly Ala Gly Ala Arg     130 135 140 Ile Gln Glu Gly Val Thr Ala Leu Ala Gly Tyr Gly Gly Ile Phe Arg 145 150 155 160 Arg Asn Val Arg Ala Ser Gly Val Val Pro Gln Ile Ser Val Met Leu                 165 170 175 Gly Pro Cys Ala Gly Gly Ala Thr Tyr Ser Pro Ala Leu Thr Asp Tyr             180 185 190 Val Phe Met Val Arg Asp Ile Ala Gln Met Tyr Ile Thr Gly Pro Asp         195 200 205 Val Val Ser Ala Val Thr Gly Glu Glu Ile Thr His Glu Glu Leu Gly     210 215 220 Gly Ala Glu Val His Ala Thr Glu Ser Gly Ala Gly Ala Phe Val Tyr 225 230 235 240 Asp Asp Glu Glu Ser Cys Phe Ala Asp Val Arg His Leu Val Ser Leu                 245 250 255 Leu Pro Ser Asn Asn Arg Glu Gln Pro Pro Val Ala Pro Thr Ala Asp             260 265 270 Pro Pro Asp Arg Ala Thr Pro Ser Leu Leu Asp Ile Val Pro Ala Asp         275 280 285 Thr Thr Arg Ala Tyr Asp Met Arg Asp Val Ile Ala Glu Val Val Asp     290 295 300 Asp Gly Asp Leu Phe Glu Val His Ala Asn Trp Ala Thr Asn Ile Val 305 310 315 320 Cys Gly Leu Ala Arg Leu Asp Gly His Thr Val Gly Ile Val Ala Asn                 325 330 335 Gln Pro Ala Ser Leu Ala Gly Val Leu Asp Ile His Ala Ser Glu Lys             340 345 350 Ala Ala Arg Phe Val Ser Thr Cys Asp Ser Phe Ser Ile Pro Leu Val         355 360 365 Thr Leu Val Asp Val Pro Gly Phe Leu Pro Gly Gly Asp Gln Glu Arg     370 375 380 Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu Tyr Ala Tyr Cys Ala 385 390 395 400 Ala Thr Val Pro Arg Val Gln Leu Ile Leu Arg Lys Ala Tyr Gly Gly                 405 410 415 Ala Tyr Ile Val Met Asp Ser Arg Ser Ile Gly Ala Asp Leu Ser Leu             420 425 430 Ala Trp Pro Thr Asn Glu Ile Ala Val Met Gly Ala Glu Ala Ala Ala         435 440 445 Asn Val Val Phe Arg Arg Glu Ile Ala Ala Ala Pro Asp Pro Glu Ile     450 455 460 Ala Arg Ala Gln Arg Ile Lys Gln Tyr Arg Asn Asp Leu Met His Pro 465 470 475 480 Tyr Tyr Ala Ala Glu Ala Gly Leu Val Asp Asp Val Ile Asp Pro Ser                 485 490 495 Asp Thr Arg Ala Val Leu Val Asp Ala Leu Ser Met Leu Arg Ala Lys             500 505 510 Arg Ala Glu Leu Pro Val Arg Lys His Gly Asn Pro Pro Thr         515 520 525 <210> 21 <211> 213 <212> PRT <213> Pseudonocardia autotrophica <400> 21 Met Arg Val Leu Pro Tyr Asp Gly Asp Thr Thr Glu Arg Ile Ser Gln 1 5 10 15 Glu Ser Thr Ser Ala Cys Met Val Ser Leu Asp Arg Gly Leu Arg Val             20 25 30 Val Ala Ala Asn Gln Glu Met Phe Arg Arg Met Cys Asp Ile Gly Ser         35 40 45 Gly Asp Val Cys Gly Ser Ala Phe Cys Asp Leu Leu Asp Gly Ser Ile     50 55 60 Arg Thr Arg Val Arg His Gln Met Glu Arg Leu Leu Asp Gly Gln Gln 65 70 75 80 Pro Arg Phe Gln Glu Arg Ser Val Ala Ile Ala Gly Ala Gly Ser Ser                 85 90 95 Leu Arg Gly Asp Leu Met Ala Thr Ala Ile Ala Arg Asn Ala Gly Arg             100 105 110 Val Glu Gly Val Val Val Val Leu Arg Thr Gly Asp Ala Glu Pro Ser         115 120 125 Thr Ala Trp Ser Gly Pro Arg Arg Ile Leu Ser Asp Met Asp Ala Lys     130 135 140 Ile Leu Glu Gly Val Ala Ser Gly Ala Ser Thr Val Gln Leu Ala Ser 145 150 155 160 Thr Leu Phe Leu Ser Arg Gly Gly Val Glu Tyr His Val Thr Ala Leu                 165 170 175 Leu Arg Lys Met Arg Val Lys Asn Arg Pro Ala Leu Ile Ser Lys Ala             180 185 190 Tyr Ser Met Gly Phe Phe Glu Leu Gly Ser Trp Pro Pro Gln Val Val         195 200 205 Pro Asp His Val Lys     210 <210> 22 <211> 138 <212> PRT <213> Pseudonocardia autotrophica <400> 22 Met Leu Val Val Ser Gly Arg His Arg Arg His Ser Pro Pro Ser Met 1 5 10 15 Thr Ile Gly Asp Gly Gln His Glu Arg Ile Met Ser Gly Met Arg Arg             20 25 30 Thr Gly Asp Val Ala Gly Pro Gly Leu Val Gly Arg Ala Arg Pro Thr         35 40 45 Pro Arg Gly Ile Asp Val Glu Pro Val Pro Gly Leu Thr Val Arg Val     50 55 60 Leu Asp Thr Gly Trp Met Glu Leu Gly His Pro Ser Arg Cys Asp Arg 65 70 75 80 Leu Leu Cys Asp Glu Val Gly Thr Ala Met Trp Leu Ala Leu Cys Arg                 85 90 95 Thr Ala Trp Asn Leu Gly Asp Ala Ala Ala His Leu Ala Asp Leu Trp             100 105 110 Asp Thr Asp Pro Trp Ala Met Arg Asp Met Met Asp Asp Trp Leu Asp         115 120 125 Asp Leu Arg Glu Ala Gly Leu Val Arg Tyr     130 135 <210> 23 <211> 963 <212> PRT <213> Pseudonocardia autotrophica <400> 23 Met Ala Cys Thr Ser Val Gly Arg Arg Ser Tyr Glu Cys Arg Gly Pro 1 5 10 15 Thr Leu Gly Ser Arg Pro Ser Gly Gly Pro Arg Gly Ala Pro Arg Ala             20 25 30 Arg Arg Pro Thr Ala Gly Pro Ser Leu Met Pro Arg Pro Val Leu Leu         35 40 45 Gly Arg Ala Gly Asp Leu Ala Glu Val Asp Gly Ala Leu Ala Arg Ala     50 55 60 Val Gly Gly Thr Ala Ser Leu Leu Val Phe Thr Gly Pro Ile Gly Ile 65 70 75 80 Gly Arg Thr Ala Leu Leu Glu Glu Cys Ala Arg Arg Gly Ala Ala Arg                 85 90 95 Gly Met Gln Val Ala Arg Ala Gly Gly Thr Asp Glu Glu Gly Gly Ile             100 105 110 Pro Leu Gly Thr Ala Arg Glu Leu Leu Ala Ala Cys Gly Gly Pro Gly         115 120 125 Pro Ser Pro Pro Cys Gly Glu Pro Asp Gly Asp Asp Thr Gly Ala Leu     130 135 140 Ser Ala Ala Leu Ala Gly Arg Ala Ala Val Gly Pro Val Leu Leu Leu 145 150 155 160 Val Asp Asp Ala Ala Arg Cys Asp Ala Arg Ser Leu Arg Trp Leu Ala                 165 170 175 Arg Leu Cys Cys Pro Arg Ala Cys Leu Arg Val Ala Val Val Leu Thr             180 185 190 Val Leu Asp Gly Asp Ala Gly His Asp Gly Gly Thr Arg His Gly Gly         195 200 205 Ala Thr Gly Gly Leu Pro Thr Glu Leu Ala Ala Val Ala Asp Ala Val     210 215 220 Arg Pro Leu Gly Pro Leu Ser Asp Glu Ala Ile Ser Val Thr Ala Arg 225 230 235 240 Ala Val Leu Gly Arg Asp Ala Thr Pro Glu Leu Val Ala Ala Leu Ser                 245 250 255 Ala Ala Thr Glu Gly Asn Pro Leu His Leu Thr Cys Val Leu Glu Glu             260 265 270 Leu Ala Ala Arg Pro Gln Cys Thr Thr Glu Pro Pro Ala Arg Arg Val         275 280 285 Ala Gly Ala Ala Pro Ala Arg Leu Arg Asp Arg Phe Ala His Ala Val     290 295 300 Arg Arg Leu Pro Ala Thr Glu Arg Arg Tyr Leu Ala Ala Val Ala Val 305 310 315 320 Ala Gly Glu Lys Ala Asp Asp Val Met Leu Ala Arg Leu Ala Glu Leu                 325 330 335 Asp Ala Thr Asp Leu Ala Val Ala Gly Ala Val Thr Arg Ser Met Gly             340 345 350 Leu Thr Gly Pro Glu Gly His Arg Leu Arg His Gly Leu Val Gly Ala         355 360 365 Ala Leu Gly Val Val Gln Ser Ser His Gln Arg Arg Asp Leu His Leu     370 375 380 Arg Ala Ala Arg Met Leu Arg Asp Ala Gly Ala Pro Ser Asp Arg Ile 385 390 395 400 Ala Ala His Leu Leu Thr Ala Gly Gly Ala Ala Pro Ala Trp Thr Val                 405 410 415 Glu Ala Leu Arg Asp Ala Ala Gly Thr Ala Val Arg Arg Gly Glu Ser             420 425 430 Trp Thr Ala Val Arg Tyr Leu Arg His Ala Leu Leu Ala Gly Pro Asp         435 440 445 Glu Pro Gly Arg Ala Ala Val Leu Leu Asp Leu Ala Gly Leu Glu Arg     450 455 460 Ser Arg Asp Thr Gly Leu Ala Leu Arg Arg Ile Val Gln Ala Val Pro 465 470 475 480 Leu Leu Gly Ser Leu Arg Glu Arg Ala Ala Ala Leu Cys Arg Val Thr                 485 490 495 Pro Leu Ala Leu Glu Gly Ala Ala Pro Pro Val Ile Ala Leu Leu Arg             500 505 510 Gly Val Ala Glu Glu Leu Gly Arg Tyr Gly Gly Thr Gly Asp Thr Glu         515 520 525 Thr Arg Glu Leu Ala Leu Arg Val Glu Ala Arg Leu His Tyr Val Asp     530 535 540 Lys His Thr Arg Ala Gly Leu Ser Ala Ala Ala Ala Arg Leu Asp Glu 545 550 555 560 Leu Glu Ala Leu Pro Asp Gly Leu Pro Ile Arg Thr Pro Gly Glu Arg                 565 570 575 Glu Leu Ala Cys Val Leu Leu His Ser Ala Ala Val Gly Gly His Arg             580 585 590 Pro Ala Ser Val Val Ala Ala Ala Cys Arg Ala Val Leu Ala Arg Glu         595 600 605 Pro Ala Ser Ser Asp His Val His Ser Thr Val Gly Met Leu Val Thr     610 615 620 Cys Leu Cys Met Ala Asp Ala Val Glu Asp Leu Pro Ser Trp Leu Ser 625 630 635 640 Val Ala Leu Glu Gln Ala Arg Ala Glu Arg Ala Pro Val Val Glu Ala                 645 650 655 Val Leu His Ala Glu Leu Ala Ala Val Leu Val Cys Ser Gly Arg Val             660 665 670 Glu Glu Ala Ala Glu Gln Val Arg Ser Ala Val Glu Leu Val Asp Glu         675 680 685 Leu Ala Asp Asp Ser Leu Leu Pro Gly Thr Val Leu Ala Pro Val Leu     690 695 700 Thr Ala Val Pro His Gly Pro Gly Ala Asp Arg Val Leu Ala Arg Tyr 705 710 715 720 Gly Ala Thr Pro Ser Val Pro Pro Gly Phe Gly Ala Cys Leu Gln Met                 725 730 735 Leu Arg Ala Arg Val Ala Ala Glu Ala Gly Asp Ala Glu Thr Ala Leu             740 745 750 Glu Tyr Cys Leu Asp Ala Gly Arg Arg Phe Asp Gln Ala Gly Trp Thr         755 760 765 Ala Thr Pro Val Pro Trp Arg Pro Trp Ala Val Glu Ile Leu Ala Glu     770 775 780 Arg Gly Arg Arg Ala Glu Ala Arg Ala Leu Ala Glu Gln Glu Leu Ala 785 790 795 800 Arg Ala Arg Arg Trp Gly Ala Pro Ala Gln Leu Gly Arg Ala Leu Arg                 805 810 815 Met Leu Gly Gln Leu Gly Gly Thr Asp Arg Gly Ala Glu Leu Leu Glu             820 825 830 Gln Ala Thr Ile Val Leu Arg Thr Ser Gly Asp Arg Ser Glu Ala Glu         835 840 845 Arg Ala Thr Arg Ala Leu Thr Ala His Arg Ala Pro Pro Gly Pro Gly     850 855 860 Asp Leu Pro Pro Arg Thr Gly Asp Pro Ala Gly Pro Pro Pro Arg Leu 865 870 875 880 His Asp Thr Val Gly Thr Pro Val Pro Gly His Arg Pro Thr Ser Arg                 885 890 895 Ala Ser Ala Ala Leu Thr Arg Ser Glu Glu Arg Val Ala Thr Arg Ala             900 905 910 Ser Arg Gly Leu Thr Asn His Glu Ile Ala Ala Asp Leu Ala Val Ser         915 920 925 Val Arg Ala Val Glu Lys His Leu Thr Gly Val Tyr Arg Lys Leu Gly     930 935 940 Val Pro Gly Arg Ala Ala Leu Arg Gln Leu Arg Glu Ser Gly Ser Asp 945 950 955 960 Arg Ile Ala              <210> 24 <211> 684 <212> PRT <213> Pseudonocardia autotrophica <400> 24 Met Ala Ala Met Leu Arg His Glu Pro Pro Gly Val Val Glu Leu Ala 1 5 10 15 Arg Ala Val Ala Val Leu Glu Pro Asp Ala Asp Ala Gly Thr Arg Ala             20 25 30 Arg Val Ala Gly Leu Asp Asp Val Ala Ala Ala His Ala Ala Glu Arg         35 40 45 Leu Val Glu Leu Gly Val Leu Asp Gly His Arg Cys Gly His Asp Pro     50 55 60 Ala Arg Thr Ala Val Leu Glu Ala Ala Gly Ala Asp Arg Cys Arg Arg 65 70 75 80 Leu His Ala Arg Ala Ala Arg Val Leu Asp Ser Glu Gly Ala Pro Leu                 85 90 95 Asp Arg Val Ala Asp His His Leu Ala Ala Gly Pro Pro Arg Asp Gly             100 105 110 Gly Val Val Glu Leu Leu His Val Ala Ala Ala Arg Ala Glu Gln Arg         115 120 125 Gly Asp Arg Val Arg Ala Arg Arg Leu Leu Glu His Thr Leu Thr Gly     130 135 140 Pro Val Gly Gly Arg Arg Arg Ala Ala Leu Leu Val Asp Leu Ser Val 145 150 155 160 Val Glu Arg Val Ala Ala Pro Ala Thr Ala Arg Gly His Leu Val Glu                 165 170 175 Ala Leu Ser Leu Leu Pro Cys Ala Arg Glu Arg Ala Glu Leu Leu Ala             180 185 190 Arg Thr Val Ala Arg Ser Pro Gly Gly Ala Val Asp Leu Ala Pro Leu         195 200 205 Leu Glu Asp Val Leu Arg Asp Leu Ala Asp Ala Gly Thr Gly Thr Ser     210 215 220 Gly Gln Asp Arg Glu Leu Arg Gln Arg Leu Glu Ala Leu Val Leu His 225 230 235 240 Ala Ala Cys Glu Asp Pro Ser Gly Ala Ala Arg Val Trp Glu Trp Val                 245 250 255 Ala Arg Thr Asp Pro Gly Glu Leu Gly Ala Gly Ala Gly Ala Asp Val             260 265 270 Leu Arg Ser Ala His Leu Leu Phe Ser Ala Leu Ala Leu His Thr Asp         275 280 285 Ala Ala Thr Ala Ala Ala Arg Thr Ala Glu Ala Met Pro Ala Asp Leu     290 295 300 Glu Asp Asp Ala Tyr Leu His Pro Met Gln Val Ala Ala Leu Gly Leu 305 310 315 320 Leu Cys Trp Ala Glu Ala Thr Thr Gly Leu Asp Gly Val Arg Arg Arg                 325 330 335 Thr Leu Asp Ala Ala His Arg Thr His Arg Thr Asp Val Glu Ala Phe             340 345 350 Leu Arg Gly Val Asp Ala Met Leu Leu Leu Arg Arg Gly Gln Val Pro         355 360 365 Ala Ala Leu Ala Ala Ala Arg Ala Ser Leu Asp Val Leu Thr Gly Ala     370 375 380 Thr Arg Leu Met Val Leu Arg Ala Ala Thr Leu Ala Leu Val Glu Leu 385 390 395 400 Gly Arg Thr Ala Glu Ala Glu Arg Leu Leu Ala Pro Val Asp Asp Arg                 405 410 415 Ser Ser Ala Asp Arg Thr Trp Arg Trp Asn Tyr Leu Leu Asp Ala Arg             420 425 430 Ala Ala Val Leu Ala Ala Thr Gly Arg Thr Arg Glu Ala Leu Ala Leu         435 440 445 Thr Leu Glu Cys Gly His Arg Leu Met Ala Val Gly Ile Val Asn Pro     450 455 460 Val Val Leu Asp Trp Arg Arg Arg Ala Val Glu Leu His His Glu Leu 465 470 475 480 Gly Glu His Glu Ala Ala Thr Ala Ala Ala Glu Glu Tyr Val Thr Leu                 485 490 495 Cys Arg Leu Trp Gly Pro Glu Gly Tyr Gly Gly Ala Ala Leu Arg Val             500 505 510 Leu Gly Leu Val Gln Gly Gly Glu Arg Gly Leu Ala Thr Leu His Ser         515 520 525 Ala Arg Ala Glu Leu Gly Ala Ser Pro Leu Ala Leu Asp Arg Ala Arg     530 535 540 Cys Thr Val Asp Leu Gly Ala Arg Met Arg Ala His Gly Ala Ala Gly 545 550 555 560 Glu Ala Arg Ala Leu Leu Arg His Gly Leu Glu Leu Ala Val Asp Cys                 565 570 575 Gly Ala Pro Ile Leu Ala Ala Arg Ala Arg Thr Glu Leu Ala Ala Ala             580 585 590 Gly Gly Arg Pro Arg Arg Gly Gly Ser Ser Ser Leu Thr Pro Ala Glu         595 600 605 Leu Gly Val Ala Arg Leu Ala Ala Gly Gly Ala Thr Asn Arg Asp Ile     610 615 620 Ala Ala Val Leu Gly Thr Ser Gln Arg Ala Val Glu Gly His Leu Thr 625 630 635 640 Arg Val Tyr Arg Lys Leu Glu Ile Asp Gly Arg Glu Gly Leu Ala Ser                 645 650 655 Ala Pro Gly Leu Arg Val Gly Thr Cys Arg Pro Gly Gly Gln Gly Asp             660 665 670 Val Asp Ala Pro Thr Arg Ala Val Ala Pro Arg Pro         675 680 <210> 25 <211> 23 <212> DNA <213> artificial-CYP forward primer <400> 25 tggatcggcg acgaccgsvy cgt 23 <210> 26 <211> 23 <212> DNA <213> artificial-CYP reverse primer <400> 26 ccgwasagsa ysccgtcgta ctt 23  

Claims (37)

Pseudonocardia autotrophica polyene biosynthesis gene cluster represented by the nucleotide sequence of SEQ ID NO: 1. Modular polyketide synthase (PKS) of Pseudonocadia autotrophica, including: (a) an amino acid sequence consisting of the KS, AT, ACP regions of SEQ ID NO: 13; (b) an amino acid sequence consisting of the KS1, mAT1, KR1, ACP1, KS2, mAT2, KR2, ACP2 regions of SEQ ID NO: 14; (c) KS3, AT3, DH3, KR3, ACP3, KS4, AT4, DH4, KR4, ACP4, KS5, AT5, DH5, ER5, KR5, ACP5, KS6, AT6, DH6, KR6, ACP6, KS7 , Amino acid sequence consisting of AT7, DH7, KR7, ACP7, KS8, AT8, DH8, KR8, ACP8 region; (d) KS9, AT9, DH9, KR9, ACP9, KS10, AT10, KR10, ACP10, KS11, mAT11, KR11, ACP11, KS12, AT12, KR12, ACP12, KS13, AT13, KR13, ACP13, KS14 , Amino acid sequence consisting of AT14, KR14, ACP14 region; (e) an amino acid sequence consisting of the KS15, AT15, DH15, ER15, KR15, ACP15, KS16, AT16, KR16, ACP16, KS17, AT17, DH17, KR17, ACP17 regions of SEQ ID NO: 7; And (f) the amino acid sequence consisting of the KS18, AT18, DH18, KR18, ACP18, TE18 regions of SEQ ID NO: 8. The gene encoding the modular PKS of the pseudonocardia autotrophica of claim 2. The gene of claim 3, wherein the gene is 6673-35172 (cppI), 35193-51470 (cppJ), 51508-57603 (cppK), 62823-66116 (cppA), 66162-75689 (cppB), and 75724 of SEQ ID NO: 1. A gene characterized by the nucleotide sequence of -108354 (cppC). 3. The modular PKS of Pseudo norcadia autotrophica according to claim 2, wherein KR12 and KR13 are inactive. 3. The modular PKS of Pseudonodiadia autotrophica according to claim 2, wherein AT15, AT16 and AT17 comprise acetate-specific AT. 3. The modular PKS of Pseudo norcadia autotrophica according to claim 2, wherein DH17 is inactive. 3. The modular PKS of Pseudo norcadia autotrophica according to claim 2, wherein in the amino acid sequence of SEQ ID NO: 8, histidine at position 944 is substituted with glutamic acid. Mycosamine producing protein represented by the amino acid sequence of SEQ ID NO: 5, 11 or 12. The gene encoding the mycosamine producing protein of claim 9 (cppDI, cppDII or cppDIII). The gene according to claim 10, wherein the cppDI, cppDII and cppDIII genes are represented by base sequences of regions 61190-62659, 60100-61158, and 5466-6500 of SEQ ID NO: 1, respectively. Cytochrome P-450 monooxygenase represented by the amino acid sequence of SEQ ID NO: 9 or 10. The gene encoding the cytochrome P-450 monooxygenase of claim 12 (cpp L, cppN). The gene of claim 13, wherein the cpp L and cppN genes are represented by base sequences of regions 57600-58811 and 58862-60103 of SEQ ID NO: 1, respectively. ABC transporter protein represented by the amino acid sequence of SEQ ID NO: 3 or 4. The gene encoding the ABC transporter protein of claim 15 (cpp G, cppH). The gene of claim 16, wherein the cpp G and cppH genes are represented by base sequences of regions 1551-3329 and 3421-5175 of SEQ ID NO: 1, respectively. 4-Phosphopantheteine transferases represented by the amino acid sequence of SEQ ID NO: 2. Gene encoding the 4-phosphopantetin transferase of claim 18 (cppF) The gene of claim 19, wherein the cppF gene is represented by a nucleotide sequence of region 1-675 of SEQ ID NO: 1. Thioesterase represented by the amino acid sequence of SEQ ID NO: 16  The gene encoding the thioesterase of claim 21 (cppE) The gene of claim 22, wherein the cppE gene is represented by a base sequence of region 108432-109256 of SEQ ID NO: 1. Decarboxylase represented by the amino acid sequence of SEQ ID NO: 20 The gene encoding the decarboxylase of claim 24 (cppO) The gene according to claim 25, wherein the cppO gene is represented by a nucleotide sequence of region 117603-119183 of SEQ ID NO: 1. Ferredoxin protein represented by the amino acid sequence of SEQ ID NO: 22. A gene encoding the peredoxin protein of claim 27 (cppM). 29. The gene of claim 28, wherein the cppM gene is represented by a nucleotide sequence of region 120205-120621 of SEQ ID NO: 1. A transcriptional regulatory protein represented by the amino acid sequence of SEQ ID NOs: 17, 18, 19, 21, 23 or 24. A gene encoding a transcriptional regulatory protein of claim 30 (cppRI, cppRII, cppRIII, cppRIV, cppRV or cppRVI). 32. The method of claim 31, wherein the cppRI, cppRII, cppRIII, cppRIV, cppRV and cppRVI genes are respectively 109391-112231, 112240-114537, 114555-117332, 119224-119865, 120734-123625 and 123663-125717 of SEQ ID NO: 1. Gene characterized in that the base sequence. 31. The protein of claim 30, wherein the transcriptional regulator protein has an HTH DNA binding motif in the C-terminal portion. A vector comprising the gene cluster of claim 1. A bacterium transformed with the vector of claim 34. A method for producing a polyene by the bacterium of claim 35. Polyene prepared by the method of claim 36.

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