KR20100084622A - Granular jelly beverage for medication and process for producing the same - Google Patents
Granular jelly beverage for medication and process for producing the same Download PDFInfo
- Publication number
- KR20100084622A KR20100084622A KR1020107007952A KR20107007952A KR20100084622A KR 20100084622 A KR20100084622 A KR 20100084622A KR 1020107007952 A KR1020107007952 A KR 1020107007952A KR 20107007952 A KR20107007952 A KR 20107007952A KR 20100084622 A KR20100084622 A KR 20100084622A
- Authority
- KR
- South Korea
- Prior art keywords
- oil
- component
- granular jelly
- acid
- medicines
- Prior art date
Links
- 235000015110 jellies Nutrition 0.000 title claims abstract description 126
- 239000008274 jelly Substances 0.000 title claims abstract description 126
- 239000003814 drug Substances 0.000 title claims abstract description 116
- 229940079593 drug Drugs 0.000 title claims abstract description 69
- 235000013361 beverage Nutrition 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims description 14
- 241000411851 herbal medicine Species 0.000 claims abstract description 84
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 52
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 24
- 230000000595 bitter masking effect Effects 0.000 claims abstract description 21
- 235000019198 oils Nutrition 0.000 claims abstract description 13
- 239000002253 acid Substances 0.000 claims abstract description 10
- 239000004615 ingredient Substances 0.000 claims abstract description 10
- 239000000796 flavoring agent Substances 0.000 claims abstract description 9
- 150000003839 salts Chemical class 0.000 claims abstract description 9
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 8
- 235000019634 flavors Nutrition 0.000 claims abstract description 7
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 38
- 235000019640 taste Nutrition 0.000 claims description 38
- 230000002776 aggregation Effects 0.000 claims description 30
- 238000004220 aggregation Methods 0.000 claims description 30
- 235000019596 Masking bitterness Nutrition 0.000 claims description 28
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 18
- -1 percelanan Polymers 0.000 claims description 16
- 239000008187 granular material Substances 0.000 claims description 15
- 239000003921 oil Substances 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 11
- 239000000194 fatty acid Substances 0.000 claims description 11
- 229930195729 fatty acid Natural products 0.000 claims description 11
- 230000002829 reductive effect Effects 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 10
- 235000019197 fats Nutrition 0.000 claims description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 9
- 239000005871 repellent Substances 0.000 claims description 9
- 230000001629 suppression Effects 0.000 claims description 9
- 239000006188 syrup Substances 0.000 claims description 9
- 235000020357 syrup Nutrition 0.000 claims description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 230000002940 repellent Effects 0.000 claims description 8
- 235000015165 citric acid Nutrition 0.000 claims description 7
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 6
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 6
- 239000004386 Erythritol Substances 0.000 claims description 6
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- 244000299461 Theobroma cacao Species 0.000 claims description 6
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 claims description 6
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 claims description 6
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 6
- 235000014121 butter Nutrition 0.000 claims description 6
- 235000001046 cacaotero Nutrition 0.000 claims description 6
- 235000019414 erythritol Nutrition 0.000 claims description 6
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 6
- 229940009714 erythritol Drugs 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 229920001817 Agar Polymers 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- 239000002211 L-ascorbic acid Substances 0.000 claims description 5
- 235000000069 L-ascorbic acid Nutrition 0.000 claims description 5
- 229920000161 Locust bean gum Polymers 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 5
- 239000008272 agar Substances 0.000 claims description 5
- 235000010419 agar Nutrition 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- 235000010418 carrageenan Nutrition 0.000 claims description 5
- 239000000679 carrageenan Substances 0.000 claims description 5
- 229920001525 carrageenan Polymers 0.000 claims description 5
- 229940113118 carrageenan Drugs 0.000 claims description 5
- 235000010420 locust bean gum Nutrition 0.000 claims description 5
- 239000000711 locust bean gum Substances 0.000 claims description 5
- 235000010356 sorbitol Nutrition 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- 229960002920 sorbitol Drugs 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 4
- 235000019482 Palm oil Nutrition 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229920000591 gum Polymers 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 4
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- 239000002540 palm oil Substances 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- 235000010447 xylitol Nutrition 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims description 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 3
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 3
- 229920002307 Dextran Polymers 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- 229920002148 Gellan gum Polymers 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 3
- 240000003183 Manihot esculenta Species 0.000 claims description 3
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 claims description 3
- 240000007594 Oryza sativa Species 0.000 claims description 3
- 235000007164 Oryza sativa Nutrition 0.000 claims description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 3
- 235000019486 Sunflower oil Nutrition 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 239000001361 adipic acid Substances 0.000 claims description 3
- 235000011037 adipic acid Nutrition 0.000 claims description 3
- 229960000250 adipic acid Drugs 0.000 claims description 3
- 229960005261 aspartic acid Drugs 0.000 claims description 3
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 235000005687 corn oil Nutrition 0.000 claims description 3
- 239000002285 corn oil Substances 0.000 claims description 3
- 229940048879 dl tartaric acid Drugs 0.000 claims description 3
- 235000010492 gellan gum Nutrition 0.000 claims description 3
- 239000000216 gellan gum Substances 0.000 claims description 3
- 239000000174 gluconic acid Substances 0.000 claims description 3
- 235000012208 gluconic acid Nutrition 0.000 claims description 3
- 235000012209 glucono delta-lactone Nutrition 0.000 claims description 3
- 239000000182 glucono-delta-lactone Substances 0.000 claims description 3
- 229960003681 gluconolactone Drugs 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 239000000787 lecithin Substances 0.000 claims description 3
- 235000010445 lecithin Nutrition 0.000 claims description 3
- 229940067606 lecithin Drugs 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 229960001855 mannitol Drugs 0.000 claims description 3
- 239000004006 olive oil Substances 0.000 claims description 3
- 235000008390 olive oil Nutrition 0.000 claims description 3
- 229920001277 pectin Polymers 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 229960000292 pectin Drugs 0.000 claims description 3
- 235000009566 rice Nutrition 0.000 claims description 3
- 235000012424 soybean oil Nutrition 0.000 claims description 3
- 239000003549 soybean oil Substances 0.000 claims description 3
- 239000002600 sunflower oil Substances 0.000 claims description 3
- 239000008158 vegetable oil Substances 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- RVEWUBJVAHOGKA-WOYAITHZSA-N Arginine glutamate Chemical compound OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RVEWUBJVAHOGKA-WOYAITHZSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 239000001879 Curdlan Substances 0.000 claims description 2
- 229920002558 Curdlan Polymers 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 240000008415 Lactuca sativa Species 0.000 claims description 2
- 229920000057 Mannan Polymers 0.000 claims description 2
- 235000019483 Peanut oil Nutrition 0.000 claims description 2
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 2
- 240000004584 Tamarindus indica Species 0.000 claims description 2
- 235000004298 Tamarindus indica Nutrition 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
- 239000000783 alginic acid Substances 0.000 claims description 2
- 229960001126 alginic acid Drugs 0.000 claims description 2
- 150000004781 alginic acids Chemical class 0.000 claims description 2
- 239000010775 animal oil Substances 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 229940105329 carboxymethylcellulose Drugs 0.000 claims description 2
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims description 2
- 235000013351 cheese Nutrition 0.000 claims description 2
- 229960004106 citric acid Drugs 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 235000019316 curdlan Nutrition 0.000 claims description 2
- 229940078035 curdlan Drugs 0.000 claims description 2
- 229960002086 dextran Drugs 0.000 claims description 2
- 235000021323 fish oil Nutrition 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 229950006191 gluconic acid Drugs 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 229960001375 lactose Drugs 0.000 claims description 2
- 239000000944 linseed oil Substances 0.000 claims description 2
- 235000021388 linseed oil Nutrition 0.000 claims description 2
- 239000003264 margarine Substances 0.000 claims description 2
- 235000013310 margarine Nutrition 0.000 claims description 2
- 239000000312 peanut oil Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 235000012045 salad Nutrition 0.000 claims description 2
- 239000008159 sesame oil Substances 0.000 claims description 2
- 235000011803 sesame oil Nutrition 0.000 claims description 2
- 238000004904 shortening Methods 0.000 claims description 2
- 244000060011 Cocos nucifera Species 0.000 claims 1
- 235000013162 Cocos nucifera Nutrition 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000015271 coagulation Effects 0.000 abstract description 8
- 238000005345 coagulation Methods 0.000 abstract description 8
- 235000019871 vegetable fat Nutrition 0.000 abstract description 5
- 235000019737 Animal fat Nutrition 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 235000019658 bitter taste Nutrition 0.000 description 20
- 238000004519 manufacturing process Methods 0.000 description 16
- 238000013329 compounding Methods 0.000 description 11
- 239000003925 fat Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 108020003175 receptors Proteins 0.000 description 7
- 230000000873 masking effect Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 235000019606 astringent taste Nutrition 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 239000000499 gel Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000009747 swallowing Effects 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 235000019629 palatability Nutrition 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 235000019614 sour taste Nutrition 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- 150000000996 L-ascorbic acids Chemical class 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 229960002401 calcium lactate Drugs 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229940083466 soybean lecithin Drugs 0.000 description 2
- 235000019654 spicy taste Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 210000001779 taste bud Anatomy 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 244000294411 Mirabilis expansa Species 0.000 description 1
- 235000015429 Mirabilis expansa Nutrition 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 244000090599 Plantago psyllium Species 0.000 description 1
- 235000010451 Plantago psyllium Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 150000004648 butanoic acid derivatives Chemical class 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 108091005708 gustatory receptors Proteins 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013536 miso Nutrition 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 235000019643 salty taste Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 235000013322 soy milk Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000000152 swallowing effect Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/60—Drinks from legumes, e.g. lupine drinks
- A23L11/65—Soy drinks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/86—Addition of bitterness inhibitors
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Agronomy & Crop Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicines Containing Plant Substances (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
Description
본 발명은, 독특한 쓴맛, 떫은맛, 신맛, 단맛을 갖는 생약이나 한방약 등의 약제의 맛을 조정하여, 안전하게 복용이 가능한 약복용 입상 젤리 음료 및 그의 제조 방법에 관한 것이다.TECHNICAL FIELD This invention relates to the granular jelly drink for medicines which can be taken safely by adjusting the taste of medicines, such as a herbal or herbal medicine which has unique bitterness, astringent taste, sourness, and sweetness, and its manufacturing method.
종래, 내복용 약제는, 물이나 백탕(plain boild water)과 함께 복용하는 것이 일반적이다. 그러나, 이러한 물이나 백탕에서는, 삼키는 것이 곤란한 환자, 특히 고령자나 소아 등은 약의 복용이 곤란하다.Conventionally, the oral medicine is generally taken with water or plain boild water. However, in such water or white bath, it is difficult for a patient who is difficult to swallow, especially an elderly person or a child, to take a medicine.
고령자나 소아 등을 위해서, 캅셀제나 정제 등의 약제를 분쇄하여, 밥, 된장국 및 주스 등에 혼합하여 복용하는 것도 행해지고 있었지만, 시간이 걸리고 번거로우며, 약제 성분의 방출시간의 제어가 불가능해져, 약효의 저해나 화학반응을 피할 수 없다. 또한 맛의 마스킹(masking)도 불가능해져, 소기의 약효를 얻을 수 없게 되기도 한다.For elderly people and children, medicines such as capsules and tablets are pulverized and mixed with rice, miso soup, and juices, but it is time-consuming and cumbersome, and it is impossible to control the release time of the pharmaceutical ingredient. Inhibition or chemical reactions are inevitable. In addition, masking of taste is also impossible, and the desired effect may not be obtained.
본 출원인은 소기의 약효를 유지하면서, 약의 복용이 용이하게 되도록, 한천이나 카라게난(carrageenan) 등의 호료와 만니톨 등을 포함하는, 소정의 젤리 강도를 갖는 저칼로리·무설탕의 삼킴 보조 음료를 제안하여, 특허를 취득하고 있다(특허 문헌 1 참조).The present applicant proposes a low-calorie, sugar-free swallowing supplement having a predetermined jelly strength, including agar, carrageenan, and the like, and mannitol, so that the medicine is easily taken while maintaining the desired effect. The patent is acquired (refer patent document 1).
또한, 본 출원인은, 상기 삼킴 보조 음료를 개량하여, 아미노기 등의 질소 원자를 포함하는 염기성 물질을 함유하는 약제라도, 쓴맛의 마스킹이 가능해지는 쓴 맛 마스킹 입상 젤리 음료를 제안하고 있다(특허 문헌 2 참조)In addition, the present applicant has proposed a bitter masking granular jelly beverage which improves the swallowing supplement beverage and enables the masking of bitter taste even in a drug containing a basic substance containing nitrogen atoms such as an amino group (Patent Document 2). Reference)
그런데, 생약이나 한방약 등의 약제는, 일반적으로 과립상의 것이 많고, 하나 하나의 과립의 비중도 가벼운 것이 많기 때문에, 입속에 물과 함께 한방약을 넣었을 경우에, 꺼슬꺼슬, 까칠까칠한 촉감의 과립상의 한방약이 물 표면에 떠 버려, 물과 함께 삼키기 어렵다는 문제가 있다. 또한, 생약이나 한방약 등은 일반적으로 1회에 복용하는 양이 많다는 것도 물과 함께 입속으로 삼키기 어려운 원인이 되고 있다.By the way, since herbal medicines such as herbal medicines and herbal medicines generally have a lot of granular ones, and the specific gravity of each one granule is also light, when a herbal medicine is put together with water in the mouth, granular herbal medicines with a gritty and rough touch It floats on the surface of water and there is a problem that it is hard to swallow with water. In addition, herbal medicines and herbal medicines are generally taken in large quantities at one time, which is a cause of difficulty swallowing with water.
이와 같은 생약이나 한방약 등의 약제의 삼킴을 용이하게 하기 위해서, 예를 들면, 상술한 쓴맛 마스킹 입상 젤리 음료를 이용하는 것을 생각할 수 있다.In order to facilitate swallowing of such drugs such as herbal medicines and herbal medicines, it is conceivable to use the bitter masking granular jelly drink described above.
그러나 생약이나 한방약 등의 약제는 쓴맛과 함께 독특한 떫은맛, 신맛, 단맛을 나타내기 때문에, 상술한 동식물 유지를 포함한 쓴맛 마스킹 입상 젤리 음료와는 맛이 맞지 않는 경우가 있어, 사람에 따라서는 오히려 약제의 복용이 곤란하게 되는 경우가 있다. However, because drugs such as herbal medicines and herbal medicines exhibit a bitter taste, unique bitterness, sourness, and sweetness, they may not match the bitterness masking granular jelly drink including animal and vegetable fats and fats described above. It may be difficult to take.
약제와 혼합한 후의 입상 젤리 음료의 미각을 향상시키기 위해서, 예를 들면, 상술한 입상 젤리 음료에 산미료 등을 첨가하는 것도 생각할 수 있지만, 단순히 산미료를 첨가하는 것만으로는, 입상 젤리 음료를 구성하는 성분의 응집이 생기거나 적당한 겔을 형성할 수 없기 때문에, 약제를 감싸기 위해서 매우 적합한 입상의 젤리 형상이 되지 않는 경우도 있다.In order to improve the taste of the granular jelly beverage after mixing with the drug, for example, it is possible to add an acidulant or the like to the granular jelly beverage described above, but simply adding the acidulant constitutes the granular jelly beverage. Since aggregation of the components does not occur or an appropriate gel can be formed, there may be a case where the granule jelly is not very suitable in order to wrap the drug.
본 발명은, 이와 같은 종래 기술이 갖는 과제를 감안한 것이며, 그 목적은, 생약 및/또는 한방약 등의 쓴맛과 함께 독특한 떫은맛, 신맛, 단맛을 나타내는 약제라도, 약효를 떨어트리는 일 없이, 약제의 쓴맛을 마스킹 함과 동시에, 삼키기 쉽게 약제를 감쌀 수 있으며, 또한 약제와의 혼합 후에도 양호한 미각을 나타내는 약복용 입상 젤리 음료를 제공하는 것에 있다.The present invention has been made in view of the problems of such a prior art, and the object thereof is a drug that exhibits a unique astringent taste, sourness, sweetness with a bitter taste such as a herbal medicine and / or a herbal medicine. The present invention provides a granular jelly drink for medicines that can be encapsulated easily and easily swallowed and exhibits good taste even after mixing with the drug.
본 발명자는 상기 목적을 달성하려고 예의연구한 결과, 쓴맛 마스킹 성분과 산, 그의 유도체 및 그의 염으로 이루어진 군에서 선택된 적어도 1종의 맛 조정 성분을 함유하는 것과 함께, 응집 억제 겔화 성분을 함유하는 것을 이용함으로써, 상기 문제를 해결할 수 있는 것을 밝혀내고, 본 발명을 완성하기에 이르렀다.As a result of earnestly researching to achieve the above object, the present inventors have found that it contains a bitterness masking component and at least one taste adjusting component selected from the group consisting of an acid, a derivative thereof and a salt thereof, as well as containing an aggregation inhibitory gelling component. By using this, it was found that the above problem could be solved and the present invention was completed.
즉, 본 발명의 약복용 입상 젤리 음료는 생약 및/또는 한방약의 복용에 이용하는 약복용 입상 젤리 음료이며,That is, the granular jelly drink for medicine of the present invention is a granular jelly drink for medicine used for taking herbal medicine and / or herbal medicine,
생약 및/또는 한방약의 복용에 이용하는 약복용 입상 젤리 음료이며,It is a granular jelly drink for medicine used for taking a herbal medicine and / or a herbal medicine,
(a) 식물유지 및/또는 동물유지로 이루어진 쓴맛 마스킹 성분 0.1~15.0 질량%과(a) 0.1-15.0 mass% of a bitter masking component consisting of vegetable and / or animal fats and oils.
(b) 당 알코올로 이루어진 쓴맛 마스킹 보조성분 5.0~20.0 질량%과(b) 5.0-20.0 mass% of bitterness masking auxiliary component consisting of sugar alcohol
(c) 카라기난, 젤란 검, 로커스트 콩 검, 잔탄 검, 구아 검, 펙틴, 타피오카 전분 및 전분으로 이루어진 군에서 선택된 적어도 1종의 응집 억제 겔화 성분 0.1~5.0 질량%과(c) 0.1-5.0 mass% of at least one aggregation inhibitory gelling component selected from the group consisting of carrageenan, gellan gum, locust bean gum, xanthan gum, guar gum, pectin, tapioca starch and starch;
(d) 산, 그 유도체 및 그 염으로 이루어진 군에서 선택된 적어도 1종의 맛 조정 성분 0.1~5.0 질량%과(d) 0.1-5.0 mass% of at least one taste adjusting component selected from the group consisting of an acid, its derivatives and salts thereof;
(e) 잔량으로서 수분을 함유하는 것이다. (e) It contains water as a residual amount.
또한, 본 발명의 약복용 입상 젤리 음료의 제조 방법은, 약복용 입상 젤리 음료를 제조함에 있어서, 상기 쓴맛 마스킹 성분(a)과, 상기 쓴맛 마스킹 보조 성분(b)과, 상기 응집 억제 겔화 성분 (c)과, 상기 수분(e)의 적어도 일부를 혼합하여 혼합물을 얻은 후, 상기 혼합물에 상기 맛조정 성분(d)을 혼합하여 약복용 입상 젤리 음료를 제조하는 방법이다. Moreover, the manufacturing method of the granule jelly drink for medicines of this invention WHEREIN: In manufacturing a granule jelly drink for medicines, the said bitterness masking component (a), the said bitterness masking auxiliary component (b), and the said aggregation suppression gelling component ( c) and at least a portion of the water (e) are mixed to obtain a mixture, and then the flavor adjusting component (d) is mixed with the mixture to prepare a granular jelly beverage for medicine.
본 발명에 의하면, 쓴맛 마스킹 성분과 쓴맛 마스킹 보조 성분과 맛 조정 성분을 이용함과 동시에, 응집 억제 겔화 성분을 이용함으로써, 생약 및/또는 한방약의 약효를 떨어트리는 일 없이, 이들 약제의 쓴맛을 마스킹하여, 삼키기 쉽게 약제를 감쌀 수 있는 한편, 생약 및/또는 한방약으로 이루어진 약제와의 혼합 후에도 양호한 미각을 나타내는 약복용 입상 젤리 음료 및 그 제조 방법을 제공할 수 있다. According to the present invention, by using a bitter masking component, a bitter masking auxiliary component and a taste adjusting component, and by using an aggregation inhibitory gelling component, masking the bitter taste of these drugs without degrading the efficacy of the herbal medicine and / or herbal medicine It is possible to provide a medicine-coated granular jelly beverage which can be wrapped easily with a medicine and exhibits a good taste even after mixing with a medicine consisting of a herbal medicine and / or a herbal medicine and a method for producing the same.
[도 1] 본 발명의 약복용 입상 젤리 음료의 제조 공정의 일례를 나타내는 흐름도이다.
[도 2] 본 발명의 약복용 입상 젤리 음료의 제조 공정의 다른 예를 나타내는 흐름도이다.BRIEF DESCRIPTION OF THE DRAWINGS It is a flowchart which shows an example of the manufacturing process of the granular jelly drink for medicines of this invention.
2 is a flowchart showing another example of the manufacturing process of the granular jelly beverage for medicine according to the present invention.
이하, 본 발명의 성형품에 대하여 상세하게 설명한다. 또한 본 명세서에서 「%」는 특별히 기재하지 않는 한 질량 백분율을 의미하는 것으로 한다. EMBODIMENT OF THE INVENTION Hereinafter, the molded article of this invention is demonstrated in detail. In addition, in this specification, "%" shall mean a mass percentage unless there is particular notice.
상술한 바와 같이, 본 발명의 약복용 입상 젤리 음료는 생약 및/또는 한방약의 복용을 용이하게 하는 것이며, (a)식물유지 및/또는 동물유지로 이루어진 쓴맛 마스킹 성분 0.1~15.0%과, (b)당 알코올로 이루어진 쓴맛 마스킹 보조 성분 5.0~20.0%과, (c)응집 억제 겔화 성분 0.1~5.0%과 (d)산, 그 유도체 및 그 염으로 이루어진 군에서 선택된 적어도 1종의 맛조정 성분 0.1~5.0%과. (e) 잔량으로서 수분과, 필요에 따라 (f) 발수 억제 성분 0.01~1.5%를 함유하는 것이다.As described above, the granular jelly drink for medicine of the present invention is to facilitate the taking of herbal medicine and / or herbal medicine, and (a) 0.1-15.0% of the bitterness masking component consisting of vegetable and / or animal fat, and (b At least one flavor adjusting component selected from the group consisting of 5.0-20.0% of a bitter masking auxiliary component consisting of a sugar alcohol, 0.1-5.0% of an aggregation inhibitory gelling component, and (d) an acid, a derivative thereof, and a salt thereof. With ~ 5.0%. (e) It contains water and 0.01-1.5% of (f) water repellency suppression components as needed in remainder.
[(a)쓴맛 마스킹 성분] [(a) Bitter Masking Ingredients]
본 발명의 약복용 입상 젤리 음료의 쓴맛 마스킹 성분은, 식물유지 및/또는 동물유지의 적어도 한쪽이지만, 이들은 사람의 미뢰(human tase bud)에 존재하는 쓴맛을 느끼는 수용체에 결합하여, 약제 등의 쓴맛 성분이, 이 쓴맛 수용체에 결합하는 것을 차단하는 기능을 담당한다.The bitterness masking component of the granular jelly beverage for medicine of the present invention is at least one of vegetable oil and / or animal oil, but these bind to receptors that feel bitter present in the human tase bud, and thus the bitter taste of drugs and the like. The component is responsible for blocking the binding of this bitter receptor.
즉, 음식물 등의 미각은, 사람은 혀의 표면 근방에 존재하는 미뢰라는 미각의 수용기로 인식된다. 이 미뢰는 직경 50㎛ 정도의 크기이며, 혀의 내부에 미각 세포가 있어, 이 세포막 표면에, 쓴맛, 신맛, 짠맛 및 별미 등을 느끼는 수용체가 존재한다. 그리고 타액과 섞여 수용액이 된 약물의 쓴맛 물질이, 쓴맛 수용체에 결합하면, 미각 세포의 세포막 내외의 전위차를 바꾸고, 이 전위차가 신경섬유를 통해 대뇌피질에 전달되어 쓴맛을 느낀다. That is, the taste of food and the like is recognized as a taste receptor called taste bud which exists in the vicinity of the surface of the tongue. This taste bud is about 50 micrometers in diameter, and there are taste cells in the inside of a tongue, and the receptor which feels bitter taste, sour taste, salty taste, and delicacy exists on the surface of this cell membrane. When the bitter substance of the drug mixed with saliva becomes an aqueous solution, binds to the bitter receptor, the potential difference inside and outside the cell membrane of the taste cell is changed, and the potential difference is transmitted to the cerebral cortex through the nerve fibers to feel the bitter taste.
본 발명에서, 쓴맛 마스킹 성분은, 이러한 쓴맛 수용체에 쓴맛 성분보다도 빨리 결합하여, 쓴맛 수용체를 커버하며, 쓴맛 물질과 쓴맛 수용체가 결합하는 것을 차단함으로써, 미각 세포의 흥분을 억제하여, 전위차의 발생을 방지하고 있다.In the present invention, the bitterness masking component binds to the bitter receptor faster than the bitter component, covers the bitter receptor, blocks the binding of the bitter substance and the bitter receptor, thereby suppressing the excitement of taste cells and suppressing the occurrence of potential difference. It is preventing.
상기 동식물 유지로서는 상기의 기능을 담당하는 한 특별히 한정되는 것은 아니지만, 식물유지로서는 카카오 유지, 레시틴, 대두유, 샐러드유, 식용 새플라워(safflower)유, 해바라기유, 유채씨유, 옥수수유, 쌀 기름, 낙화생유, 올리브유, 참기름, 아마인유, 코코넛유, 팜유, 야자유, 조제유, 마가린 또는 쇼트닝 및 이들의 임의 혼합물을 열거할 수 있다. 또한 동물유지로서는 라드(lard), 무염 버터(unsalted butter), 버터, 치즈, 크림, 육지방 또는 어유 및 이들의 임의 혼합물을 들 수 있다.The animal and vegetable fats and oils are not particularly limited as long as they are responsible for the above functions, but plant fats and oils include cacao fat, lecithin, soybean oil, salad oil, edible safflower oil, sunflower oil, rapeseed oil, corn oil and rice oil. , Peanut oil, olive oil, sesame oil, linseed oil, coconut oil, palm oil, palm oil, crude oil, margarine or shortening and any mixture thereof. In addition, animal fats and oils include lard, unsalted butter, butter, cheese, cream, land or fish oil, and any mixture thereof.
이들 동식물 유지 중에서도, 무염 버터, 버터, 대두유, 레시틴, 올리브유, 옥수수유 및 카카오유가 매우 적합하고, 카카오 유지가 최적이다.Among these animal and vegetable fats and oils, unsalted butter, butter, soybean oil, lecithin, olive oil, corn oil and cacao oil are very suitable, and cacao fat is optimal.
또한, 상술한 동식물 유지 이외에도, 우유, 두유 및 이러한 엑기스분을 이용하는 것도 가능하다.In addition to the above-described fats and oils and fats and oils, it is also possible to use milk, soy milk and such extract powder.
본 발명의 약복용 입상 젤리 음료에 있어서, 쓴맛 마스킹 성분의 배합량은, 0.10~15.0%이지만, 더욱 바람직하게는 0.20~13.0%, 더더욱 바람직하게는 0.25~11.0%이다.In the granular jelly drink for medicine according to the present invention, the blending amount of the bitter masking component is 0.10 to 15.0%, more preferably 0.20 to 13.0%, still more preferably 0.25 to 11.0%.
상기 배합량이 0.1% 미만에서는 쓴맛 마스킹 효과를 충분히 얻지 못하고, 15.0%를 넘으면, 젤리의 물성이 변화해 버려 적정한 젤리 강도를 얻을 수 없다.If the blending amount is less than 0.1%, the bitterness masking effect is not sufficiently obtained. If the blending amount exceeds 15.0%, the physical properties of the jelly change, and appropriate jelly strength cannot be obtained.
[(b)쓴맛 마스킹 보조 성분] [(b) Bitter Masking Supplement]
본 발명의 약복용 입상 젤리 음료의 쓴맛 마스킹 보조 성분(b)은, 당 알코올이지만, 이들은 감미료로서 작용하므로 쓴맛 마스크의 보조 작용이 있다. 또한 이들은 겔의 안정성을 향상하는 기능도 갖는다.Although the bitterness masking auxiliary component (b) of the granular jelly drink for medicines of this invention is a sugar alcohol, since it acts as a sweetener, it has an auxiliary action of a bitter mask. They also have the function of improving the stability of the gel.
당 알코올로서는 특별히 한정되는 것은 아니지만 환원 맥아당 물엿, 환원 물엿, 환원 유당, 자일리톨, 에리트리톨(erythritol), 소르비톨 또는 만니톨 및 이들의 임의 혼합물을 예시할 수 있다. 이들 당 알코올 중에서도, 에리트리톨, 환원 맥아당 물엿, 환원 물엿, 자일리톨 및 소르비톨이 매우 적합하다.Examples of the sugar alcohol include, but are not particularly limited to, reduced maltose syrup, reduced syrup, reduced lactose, xylitol, erythritol, sorbitol or mannitol, and any mixture thereof. Among these sugar alcohols, erythritol, reduced maltose syrup, reduced syrup, xylitol and sorbitol are very suitable.
본 발명의 약복용 입상 젤리 음료에 있어서 쓴맛 마스킹 보조 성분의 배합량은 5.0~20.0%이며, 바람직하게는 6.0~18.0%, 더욱 바람직하게는 8.0~16.0%이다.The compounding quantity of the bitterness masking auxiliary component in the granular jelly drink for medicines of this invention is 5.0-20.0%, Preferably it is 6.0-18.0%, More preferably, it is 8.0-16.0%.
상기 배합량이 5.0%미만에서는, 충분한 쓴맛 마스킹 보조 효과를 얻지 못하고, 20.0%를 넘게 첨가해도, 그 효과가 포화해 버려, 유의한 차이를 볼 수 없다.When the said compounding quantity is less than 5.0%, sufficient bitterness masking assistance effect is not acquired, and even if it adds more than 20.0%, the effect will be saturated and a significant difference will not be seen.
[(c) 응집 억제 겔화 성분] [(c) Coagulation Suppression Gelation Component]
본 명세서에 있어서, 응집 억제 겔화 성분이란 약복용 입상 젤리 음료를 산성 영역으로 했을 경우에, 약복용 입상 젤리 음료가 응집하는 것을 억제하며, 겔화 성분으로도 기능하는 것을 말한다.In the present specification, when the coagulant suppressing gelling component is an acidic region, the coagulation suppressing gelling component inhibits coagulation of the cognate granular jelly beverage and also functions as a gelling component.
종래의 쓴맛 마스킹 입상 젤리 음료는, 분자 내에 아미노기 등에 유래하는 질소 원자를 포함하는 염기성 물질을 함유하는 약제를 매우 적합하게 감싸서, 약제의 복용을 용이하게 하는 한편, 입속에서 약물용출에 의한 쓴맛 감지를 억제하기 때문에, pH가 5~8의 중성범위의 것이었다(일본특허출원 2003-321623호 참조).Conventional bitterness masking granular jelly beverages suitably encapsulate a drug containing a basic substance containing a nitrogen atom derived from an amino group or the like in a molecule to facilitate taking of the drug, and detect the bitter taste by eluting the drug in the mouth. In order to suppress, pH was the neutral range of 5-8 (refer Japanese patent application 2003-321623).
한편, 생약 및/또는 생약을 포함한 한방약 등은, 이들 약제를 용해한 수용액이, 일반적으로 산성의 것이기 때문에, pH 5~8의 중성 영역의 쓴맛 마스킹 입상 젤리 음료와 약제와의 맛이 어울리지 않고, 기호성이 저하하여, 사람에 따라서는, 반대로 약제를 삼키기 어려워질 뿐만 아니라, 한방약의 약효를 저해하는 경우도 생긴다.On the other hand, herbal medicines containing herbal medicines and / or herbal medicines are generally acidic, so that the taste of the bitterness masking granular jelly beverage in the neutral region of pH 5 to 8 does not match the taste and the palatability. As a result of this decrease, some people, on the contrary, make it difficult to swallow the drug, and in some cases, the drug efficacy of the herbal medicine is inhibited.
예를 들면, 한방약 등과 맛이 어울리도록, 상술한 입상 젤리 음료에 단순히 산미료를 첨가한 것 만으로는, 쓴맛 마스킹 성분과 겔화 성분 등과의 용해성의 저하나 화학반응에 의해 응집을 일으키거나 겔을 형성하지 않는 경우가 있어, 약제를 감싸는데 매우 적합한 입상 젤리의 형태가 되지 않는 경우가 있다.For example, simply adding an acidulant to the above-mentioned granular jelly drink so that the taste matches herbal medicines and the like does not cause aggregation or gel formation due to a decrease in the solubility of the bitterness masking component and the gelling component or a chemical reaction. In some cases, it may not be in the form of granular jelly, which is very suitable for wrapping a drug.
여기서, 본 발명에서는, 쓴맛 마스킹 성분(a), 쓴맛 마스킹 보조 성분(b), 맛조정 성분(d)과 함께, 응집 억제 겔화 성분(c)을 함유하는 것에 의해서, 쓴맛 마스킹 성분과 맛조정 성분이 응집 등을 일으키는 일 없이, 약복용 입상 젤리 음료의 미각을 향상시키는 한편, 적당히 단단한 젤리 물성을 갖고, 한방약 등을 감쌀 수 있어 복용량이 많은 한방약 등이라도, 삼킴을 용이하게 할 수 있도록 하고 있다.Here, in this invention, a bitterness masking component and a flavor adjustment component are contained by containing a coagulation suppression gelling component (c) with bitterness masking component (a), bitterness masking auxiliary component (b), and taste adjustment component (d). It improves the taste of the granular jelly drink for medicines without causing this aggregation, etc., has moderately hard jelly properties, can wrap herbal medicines, etc., and makes it easy to swallow even a large dose of herbal medicines and the like.
겔화 성분으로서도 기능하는 응집 억제 겔화 성분으로는, 카라기난, 젤란검, 로커스트 콩 검, 잔탄검, 구아검, 펙틴, 타피오카 전분 및 전분으로 이루어진 군에서 선택된 적어도 1종을 매우 적합하게 이용할 수 있다.As the aggregation inhibiting gelling component that also functions as a gelling component, at least one selected from the group consisting of carrageenan, gellan gum, locust bean gum, xanthan gum, guar gum, pectin, tapioca starch and starch can be suitably used.
본 발명의 약복용 입상 젤리 음료에 있어서, 응집 억제 겔화 성분의 배합량은 0.1~5.0%이며, 바람직하게는 0.1~4.0%이며, 더욱 바람직하게는 0.1~3.0%이다.In the granular jelly drink for medicine according to the present invention, the blending amount of the aggregation inhibiting gelling component is 0.1 to 5.0%, preferably 0.1 to 4.0%, and more preferably 0.1 to 3.0%.
상기 배합량이 0.1%미만에서는, 10g/㎠ 이상의 젤리 강도를 실현하지 못하고, 5.0%를 넘으면, 매우 적합한 입상이 되지 않고, 생약이나 한방약 등의 복용에 적합하지 않는 물성으로 된다.When the said compounding quantity is less than 0.1%, it cannot realize the jelly strength of 10 g / cm <2> or more, and when it exceeds 5.0%, it will not become a very suitable granularity and will become the physical property which is not suitable for taking a herbal medicine or a herbal medicine.
[(c-1) 겔화 성분] [(c-1) gelling component]
본 발명의 약복용 입상 젤리 음료는, 상술한 응집 억제 겔화 성분의 외에, 겔화 성분 (c-1)을 더욱 함유해도 좋다.The granular jelly drink for medicines of the present invention may further contain a gelling component (c-1) in addition to the above-mentioned aggregation inhibiting gelling component.
본 발명에서의 약복용 입상 젤리 음료의 겔화 성분 (c-1)으로서는, 한천, 퍼셀라란(furcellaran), 젤라틴, 커드란(curdlan), 사일리움시드검(psyllium seed gum), 알긴산, 알긴산염, 만난, 타마린드검, 덱스트란, 카르복시메틸 셀룰로오스, 카르복시메틸 셀룰로오스 나트륨 및 이들의 임의 혼합물을 병용 할 수 있다.As a gelling component (c-1) of the granular jelly drink for medicines of this invention, agar, furcellaran, gelatin, curdlan, psyllium seed gum, alginic acid, alginate , Mannan, tamarind gum, dextran, carboxymethyl cellulose, carboxymethyl cellulose sodium and any mixture thereof can be used in combination.
응집 억제 겔화 성분(c) 및 겔화 성분(c-1)의 전량 중의 응집 억제 겔화 성분의 함유율은, 바람직하게는 2.0~100.0%, 더욱 바람직하게는 5.0~95.0%, 더더욱 바람직하게는 10.0~90.0%이다.The content of the aggregation inhibiting gelling component in the total amount of the aggregation inhibiting gelling component (c) and the gelling component (c-1) is preferably 2.0 to 100.0%, more preferably 5.0 to 95.0%, even more preferably 10.0 to 90.0. %to be.
응집 억제 겔화 성분(c) 및 겔화 성분 (c-1)의 전량 중의 응집 억제 겔화 성분의 함유율이 2.0%미만이면, 맛 조정 성분을 첨가한 후에 약간의 응집이 생기는 경우가 있으므로 바람직하지 않다.If the content of the aggregation inhibiting gelling component in the total amount of the aggregation inhibiting gelling component (c) and the gelling component (c-1) is less than 2.0%, some aggregation may occur after the taste adjustment component is added, which is not preferable.
[(d) 맛 조정 성분] [(d) Taste Adjustment Ingredients]
본 발명의 약복용 입상 젤리 음료는 추가로 산, 그의 유도체 및 그의 염으로 이루어진 군에서 선택된 적어도 1종의 맛 조정 성분을 포함하는 것이다. 약복용 입상 젤리 음료의 pH가 산성 영역의 것이면, 약간의 산미를 나타내는 생약이나 한방약 등과 혼합한 경우에, 미각이 저하하지 않고, 기호성을 향상시킬 수 있다. 이 때문에, 본 발명의 약복용 입상 젤리 음료를 이용하면, 복용량이 많은 경우라도, 한방약 등의 약제를 용이하게 삼키는 것이 가능하다.The pharmaceutical granular jelly beverage of the present invention further contains at least one taste adjusting component selected from the group consisting of an acid, a derivative thereof and a salt thereof. If the pH of the medicine granular jelly drink is in the acidic region, when mixed with herbal medicines, herbal medicines, etc., which exhibit some acidity, the taste can be reduced and the palatability can be improved. For this reason, when the granular jelly drink for medicines of this invention is used, even if a large dose is used, it is possible to swallow easily medicines, such as herbal medicines.
맛 조정 성분으로는, 아디핀산, L-아스코르빈산, L-아스파라긴산, L-아르기닌, L-글루타민산, 구연산, 글루코노 델타 락톤, 글루콘산, 숙신산, DL-타타르산, L-타타르산, 락트산, 프말산, 부티르산, DL-말릭산, 이의 유도체 및 이의 염으로 이루어진 군에서 선택된 적어도 1종인 것이 바람직하다.As a taste adjustment component, adipic acid, L-ascorbic acid, L-aspartic acid, L-arginine, L-glutamic acid, citric acid, glucono delta lactone, gluconic acid, succinic acid, DL-tartaric acid, L-tartaric acid, lactic acid , At least one selected from the group consisting of fmaric acid, butyric acid, DL-malic acid, derivatives thereof and salts thereof.
구체적으로는, 아디핀산, L-아스코르빈산, L-아스코르빈산염, L-아스코르빈산에스테르, L-아스코르빈산의 유도체, L-아스파라긴산, L-아르기닌 L-글루타민산염, 구연산, 구연산염, 글루코노 델타 락톤, 글루콘산, 글루콘산염, 숙신산, 숙신산염, DL-타타르산, L-타타르산, 락트산, 락트산염, 프말산, 프말산염, 부티르산, 부티르산의 유도체, DL-말릭산 및 DL-말릭산염을 들 수 있다.Specifically, adipic acid, L-ascorbic acid, L-ascorbic acid salt, L-ascorbic acid ester, derivative of L-ascorbic acid, L-aspartic acid, L-arginine L-glutamic acid salt, citric acid, citrate , Glucono delta lactone, gluconic acid, gluconate, succinic acid, succinate, DL-tartaric acid, L-tartaric acid, lactic acid, lactic acid, fmalic acid, fmarate, butyric acid, butyric acid derivatives, DL-malic acid and DL-maleic acid salt is mentioned.
이들 산, 그의 유도체 및 그의 염 중에서도, 시트르산, L-아스코르빈산, DL-말릭이 매우 적합하다.Among these acids, derivatives thereof and salts thereof, citric acid, L-ascorbic acid and DL-malic are very suitable.
본 발명의 약복용 입상 젤리 음료에서의 맛 조정 성분의 배합량은 0.1~5.0%이며, 바람직하게는 0.1~4.0%이며, 더욱 바람직하게는 0.15~4.0%이다.The compounding quantity of the taste adjustment component in the granular jelly drink for medicines of this invention is 0.1 to 5.0%, Preferably it is 0.1 to 4.0%, More preferably, it is 0.15 to 4.0%.
상기 배합량이 0.1%미만이면, 약복용 입상 젤리 음료를, 생약이나 한방약 등과 어울리는 맛으로 개량할 수 없다. 상기 배합량이 5.0%를 넘으면, 한방약 등과 약복용 입상 젤리 음료를 혼합했을 때에 미각을 향상시키는 효과가 없을 뿐만 아니라, 응집 등이 생기기 쉬워지기 때문에 바람직하지 않다.If the said compounding quantity is less than 0.1%, the granular jelly drink for medicines cannot be improved with the taste matched with a herbal medicine and a herbal medicine. When the said compounding quantity exceeds 5.0%, since it is not effective in improving a taste when mixing herbal medicines and granular jelly drinks for medicines, and it becomes easy to produce aggregation etc., it is not preferable.
[(e) 수분] [(e) moisture]
본 발명의 약복용 입상 젤리 음료는, 수분을 포함하는 것이지만, 수분으로서는, 음료에 적절한 것이면 충분하고, 예를 들면, 수돗물, 각종 이온 교환수 및 정제수 등을 사용할 수 있다.Although the granular jelly drink for medicines of this invention contains water, what is suitable for a drink is enough as water, For example, tap water, various ion-exchange water, purified water, etc. can be used.
수분의 배합량은, 특별히 한정되는 것이 아니고, 수분 이외의 다른 성분의 잔량, 즉, 각 성분과 수분과의 합계량이 100%가 되는 양이면 좋다.The compounding quantity of water is not specifically limited, What is necessary is just the quantity which will remain 100% of remaining amounts of other components other than water, ie, the total amount of each component and water.
[(f) 발수 억제 성분] [(f) Water repellent inhibitor component]
본 발명의 약복용 입상 젤리 음료에서는, 필요에 따라, 추가로 발수 억제성분(f)을 함유할 수 있다.In the granular jelly beverage for medicines of the present invention, if necessary, the water repellent inhibitor (f) may be further contained.
발수 억제성분은, 상기 쓴맛 마스킹 성분의 발수성을 억제하여 수분과의 친화성을 좋게 하는 기능을 발휘하는 것 외에, 후술하는 쓴맛 성분이 지용성 등의 난수용성의 경우나, 제제상, 왁스 코팅이나 폴리머 코팅이 실시되어 있는 경우에는, 이들 쓴맛 성분이나 코팅과 젤리와의 친화성을 높고, 포장 기능을 효과적으로 하는 작용도 가진다.The water repellent inhibiting component exhibits a function of suppressing the water repellency of the bitter masking component to improve affinity with moisture, and in the case of the poorly water-soluble water such as fat-soluble, which is described later, in the case of a wax coating or a polymer. In the case where the coating is performed, the affinity between these bitter components, the coating and the jelly is high, and the packaging function is also effective.
이러한 발수 억제성분의 구체적인 예로는, 수크로오스 지방산 에스테르, 글리세린 지방산 에스테르, 소르비탄 지방산 에스테르, 프로필렌 글리콜, 프로필렌 글리콜 지방산 에스테르 및 이들의 임의 혼합물을 들 수 있다. Specific examples of such water repellent inhibitors include sucrose fatty acid esters, glycerin fatty acid esters, sorbitan fatty acid esters, propylene glycol, propylene glycol fatty acid esters, and any mixtures thereof.
이러한 발수 억제성분의 배합량은, 바람직하게는 0.01~1.5%, 더욱 바람직하게는 0.02~1.4%, 더더욱 바람직하게는 0.03~1.3%이다.The compounding quantity of such a water repellent inhibitor component becomes like this. Preferably it is 0.01 to 1.5%, More preferably, it is 0.02 to 1.4%, More preferably, it is 0.03 to 1.3%.
상기 배합량이 0.01%미만에서는, 충분한 발수 억제효과를 얻을 수 없는 것이 있고, 1.5%를 넘게 배합해도 효과가 포화하여 버려, 유의한 차이가 발견되지 않는 것이 있다.When the said compounding quantity is less than 0.01%, sufficient water repellent inhibitory effect may not be acquired, and even if it mix | blends more than 1.5%, an effect may become saturated and a significant difference may not be found.
또한 약복용 입상 젤리 음료에는, 본 발명이 의도하는 마스킹 효과나 삼킴 보조 효과, 추가로 미각의 향상 효과를 나타내는 한, 상기 필수 성분 이외에도, 겔화 촉진제나 영양원인 당류, 감미료, 향료, 기타 첨가제를 함유할 수 있다.In addition to the above essential ingredients, the granular jelly drink for medicine contains a gelling accelerator or a nutrient source such as sugars, sweeteners, flavoring agents, and other additives, as long as the present invention exhibits the masking effect, the swallowing effect, and the taste improvement effect. can do.
예를 들면, 겔화 촉진제로서 락트산 칼슘을 0.1~2.0% 첨가할 수 있다.For example, calcium lactate can be added 0.1 to 2.0% as a gelling accelerator.
상술한 것과 같은 성분으로 이루어진 본 발명의 약복용 입상 젤리 음료는, 생약이나 한방약 등이 본래 가지는 단맛이나 신맛 등을 억제하는 일 없이, 이들의 맛을 더욱 강조하도록 하여 미각을 향상시키는 효과가 있고, 독특한 쓴맛, 떫은맛, 신맛, 단맛을 나타내는 생약이나 한방약 등을 삼키기 쉽게 하고, 특히, 소아 등이 생약이나 한방약 등을 복용할 때에 매우 적합하게 이용할 수 있다.The granular jelly drink for medicine of the present invention comprising the above-mentioned ingredients has the effect of improving the taste by further emphasizing these tastes without suppressing the sweetness, sourness, etc. originally of the herbal medicines and herbal medicines, It is easy to swallow a herbal or herbal medicine that exhibits a unique bitterness, astringent taste, sourness, or sweet taste, and it can be particularly suitably used when a child or the like takes a herbal medicine or herbal medicine.
이하, 본 발명의 약복용 입상 젤리 음료의 성질과 상태에 대해 설명한다.Hereinafter, the nature and state of the granular jelly drink for medicine of the present invention will be described.
이 젤리 음료는 주위에 수분 등을 갖고, 형상이 균일 또는 불균일한 입상 젤리의 집합물이며, 그의 pH는, 바람직하게는 2.5~5.0, 더욱 바람직하게는 2.7~4.5, 특히 바람직하게는 3.0~4.0이다.This jelly drink is a collection of granular jelly having moisture or the like around it and having a uniform or non-uniform shape, and its pH is preferably 2.5 to 5.0, more preferably 2.7 to 4.5, and particularly preferably 3.0 to 4.0. to be.
pH가 2.5 미만인 경우, 신맛이 강해져, 생약·한방약의 쓴맛, 떫은맛을 강하게 느끼게 된다. 또한, pH가 5.0을 넘으면, 생약·한방약의 신맛, 떫은맛을 강하게 느끼게 되어, 기호성이 저하하므로 바람직하지 않다.When pH is less than 2.5, a sour taste will become strong, and the bitterness and astringency of the herbal medicine and herbal medicine will feel strong. Moreover, when pH exceeds 5.0, since the sourness and astringency of herbal medicine and herbal medicines are strongly felt, and palatability falls, it is unpreferable.
또한, 입상 젤리의 젤리강도는 20℃에서, 바람직하게는 10~100g/㎠, 더욱 바람직하게는 20~80g/㎠, 더더욱 바람직하게는 20~70g/㎠이다.In addition, the jelly strength of the granular jelly is preferably 20 to 100 g / cm 2, more preferably 20 to 80 g / cm 2, and even more preferably 20 to 70 g / cm 2 at 20 ° C.
젤리 강도가 10g/㎠ 미만에서는, 삼키는 것이 곤란한 사람에게 숨이 막힐 것과 같은 불편함을 느끼게 할 가능성이 없다고 말할 수 없으며, 100g/㎠를 넘으면, 부드럽게 삼킬 수 없을 정도로 단단해지는 경우도 있다.If the jelly strength is less than 10 g / cm 2, it cannot be said that there is no possibility of making a person who is difficult to swallow feel uncomfortable, such as choking, and if it exceeds 100 g / cm 2, it may be hard enough to be swallowed softly.
또한, 입상 젤리의 최대 길이, 즉, 통상은 기둥 모양이나 원추상, 타원구상 등의 형상의 입상 젤리에서, 그 내부를 지나는 선분(line segment)을 상정했을 경우에 가장 긴 선분의 길이는, 바람직하게는 1~10mm, 더욱 바람직하게는 1~8mm이다.The maximum length of the granular jelly, that is, in the case of a granular jelly having a columnar shape, a conical shape, an elliptic sphere shape, or the like, usually assumes a line segment passing through the inside thereof, the length of the longest line segment is preferable. Preferably it is 1-10 mm, More preferably, it is 1-8 mm.
입상 젤리의 최대길이가 1mm미만에서는, 페이스트 상에 극히 가깝게 되어, 인후에의 부착 및 체류를 일으킬 가능성이 있고, 10mm를 넘으면, 목이 막히거나 한방약 등의 약제와의 부착성이 악화할 가능성이 있다.If the maximum length of the granular jelly is less than 1 mm, it may be very close to the paste and cause adhesion and retention in the throat. If it exceeds 10 mm, it may block the neck or deteriorate the adhesion to medicines such as herbal medicines. .
본 발명의 약복용 입상 젤리 음료는, 상술한 바와 같은 형상 및 젤리 강도를 갖기 때문에, 비중이 가벼운 과립상이나 분말상의 한방약 등을 입상 젤리 음료 중에 감싸서, 입속에서 입상 젤리 음료와 약제가 분리하는 일이 없다. 이 때문에, 본 발명의 약복용 입상 젤리를 이용하는 것보다, 인후에 부착하기 쉬운 과립상이나 분말상의 생약 및/또는 한방약 등이라도, 이들 약제가 입속이나 인후에 잔존하지 않고, 정상인, 허약 체질이나 각종 질환 등으로 약제의 삼킴이 곤란한 환자 등에게, 비교적 복용량이 많아지는 한방약을 용이하게 삼키게 할 수 있다.Since the granular jelly drink for medicine of the present invention has the shape and jelly strength as described above, the granular jelly drink and the medicine are separated from the mouth by wrapping the granular or powdery herbal medicine with light specific gravity in the granular jelly drink. none. For this reason, even when using the granular jelly for medicines of this invention, even if it is a granular or powdery herbal and / or herbal medicine which is easy to adhere to a throat, these medicines do not remain in a mouth or a throat, and they are normal, weak constitution, and various diseases. It is possible to easily swallow a herbal medicine, which has a relatively high dose, for a patient or the like who is difficult to swallow the medicine with the back.
또한, 본 발명의 약복용 입상 젤리 음료는, 약제를 확실히 감쌀 수 있기 때문에, 복용량이 많은 생약이나 한방약 등의 복용에 매우 적합하다. 예를 들면, 본 발명의 약복용 입상 젤리 음료 20ml에 대하여, 2~3g의 과립상의 약제가 확실히 감싸져서, 이 약제의 복용을 용이하게 할 수 있다.Moreover, since the granular jelly drink for medicines of this invention can wrap a chemical | medical agent reliably, it is very suitable for taking a large dose of herbal medicine, herbal medicine, etc. For example, with respect to 20 ml of the granular jelly drink for medicine according to the present invention, 2-3 g of granular drugs are reliably wrapped to facilitate the taking of the drugs.
또한 예를 들면, 과립상의 한방약의 경우, 1회의 복용량은 통상 2~3g정도이다.For example, in the case of a granular herbal medicine, one dose is about 2-3 g normally.
또한, 입상 젤리가 그의 최대길이가 1~10mm의 것이라면, 한방약의 제제로서 많이 사용되고 있는 과립상의 것을, 입상 젤리로 감싸기 쉽다.Moreover, if granular jelly is a thing whose maximum length is 1-10 mm, it is easy to wrap the granular thing currently used abundantly as a herbal medicine formulation with granular jelly.
또한, 본 발명의 약복용 입상 젤리 음료는, 상술한 바와 같이 감싸는 기능을 가짐에도 불구하고, 성분의 대부분이 수분이며, 또한, 체온 정도(약 37℃)로 가열되면, 젤리 강도가 저하하여 포장 기능을 잃기 때문에, 약제의 붕괴성이나 용출성에 영향을 주는 일이 없고, 약제와의 상호작용도 일으키지 않기 때문에, 생약이나 한방약 등의 약효에 지장을 주지 않는다.In addition, although the granular jelly drink for medicine of this invention has the function to wrap as mentioned above, when most of a component is water and heats to the body temperature degree (about 37 degreeC), the jelly strength falls and it is packaged. Because it loses its function, it does not affect the disintegration or dissolution properties of the drug, and does not cause interaction with the drug, and thus does not interfere with the effects of drugs such as herbal medicines and herbal medicines.
또한, 약복용 입상 젤리 음료는, 무설탕 음료이기 때문에, 당뇨병 환자에게도 적합하며, 취침 직전에 사용해도 충치에 걸리기 어렵기 때문에 소아에게도 매우 적합하다. 또한, 살균 공정을 거쳤기 때문에, 체력이나 저항력, 면역력이 낮은 환자나 소아에게도 안심하고 사용할 수 있다.Since the granular jelly drink for medicine is a sugar-free drink, it is also suitable for diabetic patients, and is also very suitable for children because it is hard to catch tooth decay even when used just before bedtime. Moreover, since it has been sterilized, it can be used safely for patients and children with low physical strength, resistance and immunity.
본 발명의 약복용 입상 젤리 음료와 함께 복용함으로써, 삼킴이 용이해지는 약제로는, 후생노동성에 의해서 허가를 받은 한방약 처방이나 생약(고려 인삼이나 각종 허브 등)을 사용한 약제 등을 들 수 있다.Examples of the drug that can be swallowed easily by taking together with the granular jelly drink for medicine according to the present invention include a herbal medicine prescription licensed by the Ministry of Health, Labor and Welfare, and a drug using herbal medicines (Korean ginseng, various herbs, etc.).
또한, 제제의 종류로는 산제, 과립제, 환제, 캅셀제, 분말 엑기스제 및 정제 등의 고형제, 엑기스제 및 시럽제 등의 물약을 들 수 있다.Examples of the preparation include solid powders such as powders, granules, pills, capsules, powder extracts and tablets, and potions such as extracts and syrups.
이하, 본 발명의 약복용 입상 젤리 음료를 제조하는 방법의 일례를 도면에 기초하여 설명하지만, 약복용 입상 젤리 음료의 제조 방법은, 이하에 설명하는 방법으로 한정되는 것은 아니다.Hereinafter, although an example of the method of manufacturing the granular jelly drink for medicines of this invention is demonstrated based on drawing, the manufacturing method of the granular jelly drink for medicines is not limited to the method demonstrated below.
도 1은, 본 발명의 약복용 입상 젤리 음료의 제조 방법의 실시 형태의 일례를 나타내는 흐름도이다.BRIEF DESCRIPTION OF THE DRAWINGS It is a flowchart which shows an example of embodiment of the manufacturing method of the granular jelly drink for medicines of this invention.
도 1에 나타낸 바와 같이, 우선, 쓴맛 마스킹 보조 성분(b)과 응집 억제 겔화 성분 (c) 또는 겔화 성분(c-1)을 분체 혼합한 후, 이 분체 혼합물을 가온한 물(약 50℃이상)에 투입하여, 소정 시간 교반하여, 대략 균일하게 혼합한다. 다음에, 쓴맛 마스킹 성분(a)을 투입하고, 필요에 따라 발수 억제 성분(f)을 투입하여, 소정 시간 혼합한 후, 추가로 응집 억제 겔화 성분(c)을 투입하고 교반하여, 대략 균일한 혼합물을 얻는다. 그 후, 얻어진 혼합물 중에, (d) 맛 조정 성분을 투입하고, 필요에 따라 향료 등을 첨가한 후, 전량을 수분(e)으로 조정(필 업, filled up)하여, 용기에 충전하고, 필요에 따라 살균, 냉각 등을 행하여 약복용 입상 젤리 음료를 얻는다.As shown in Fig. 1, first, the bitterness masking auxiliary component (b) and the aggregation inhibiting gelling component (c) or gelling component (c-1) are powder mixed, and then the powder mixture is heated (about 50 ° C or more). ), The mixture is stirred for a predetermined time and mixed approximately uniformly. Next, the bitterness masking component (a) is added, water-repellent suppressing component (f) is added as needed, and it mixes for predetermined time, Then, the aggregation suppression gelling component (c) is further added and stirred, and it is substantially uniform. Obtain a mixture. Then, in the obtained mixture, (d) a taste adjustment component is added, a fragrance etc. are added as needed, the whole quantity is adjusted (filled up) with moisture (e), it fills in a container, and is needed Sterilization, cooling, etc. are performed accordingly, and the granular jelly drink for medicines is obtained.
또한 응집 억제 겔화 성분(c) 및/또는 겔화 성분(c)을 2회로 나누어 첨가하는 경우, 응집 억제 겔화 성분(c)을 먼저 첨가하고, 그 후에, 겔화 성분 (c-1)을 첨가해도 좋고, 그 반대여도 좋고, 2회 모두 응집 억제 겔화 성분(c)을 더해도 좋다.In addition, when adding a coagulation suppression gelling component (c) and / or a gelling component (c) in 2 parts, you may add a coagulation suppression gelling component (c) first, and may add a gelling component (c-1) after that. The reverse may be sufficient, and the aggregation inhibitory gelling component (c) may be added twice.
용액을 교반·혼합할 때, 바람직하게는 50~100℃, 더욱 바람직하게는 70~100℃로 용액을 가온하여 교반·혼합하는 것이 바람직하다.When stirring and mixing a solution, It is preferable to heat a solution at 50-100 degreeC, More preferably, it is 70-100 degreeC, stirring and mixing.
도 2는, 본 발명의 약복용 입상 젤리 음료의 제조 방법의 실시 형태의 다른 예를 나타내는 흐름도이다. 본 예의 제조 방법에서는, 우선, 쓴맛 마스킹 보조 성분(b)을 가온한 물(약 50℃이상)에 투입하고, 소정 시간 교반하고, 대략 균일하게 혼합한다. 다음에, 쓴맛 마스킹 성분(a)을 투입하고, 필요에 따라서 발수 억제성분(f)을 투입하여, 소정 시간 교반하여 혼합물(제1의 혼합물) 얻는다. 미리 가온한 물(약 50℃이상)에 혼합한 응집억제 겔화 성분(c)을, 제1의 혼합물 중에 투입하고, 교반하여, 대략 균일한 혼합물(제2의 혼합물)을 얻는다. 그 후, 얻어진 제2의 혼합물 중에, 맛조정 성분(d)을 투입하고, 필요에 따라 향료 등을 첨가한 후, 전량을 수분(e)으로 조정(필 업)하고, 용기에 충전하여, 필요에 따라 살균, 냉각하여 약복용 입상 젤리 음료를 얻는다.It is a flowchart which shows the other example of embodiment of the manufacturing method of the granular jelly drink for medicines of this invention. In the manufacturing method of this example, first, bitterness masking auxiliary component (b) is put into warm water (about 50 degreeC or more), it stirs for predetermined time, and mixes substantially uniformly. Next, a bitter masking component (a) is added, and a water repellent inhibiting component (f) is added as needed, and it is stirred for a predetermined time to obtain a mixture (first mixture). The flocculation inhibitor gelling component (c) mixed in the water (preferably 50 degreeC or more) previously heated is thrown into a 1st mixture, and it stirred, and obtains a substantially uniform mixture (2nd mixture). After that, in the obtained second mixture, a flavor adjusting component (d) is added, a flavoring agent or the like is added as necessary, and then the whole amount is adjusted (filled up) with water (e), filled in a container, and Sterilization and cooling according to the present invention provide granular jelly drink for medicine.
도 2에 나타낸 바와 같이, 응집 억제 겔화 성분(c)과 겔화 성분(c-1)과는, 양자를 분리하는 일이 없이 한번에 조제 탱크에 첨가해도 좋다.As shown in FIG. 2, the aggregation inhibiting gelling component (c) and the gelling component (c-1) may be added to the preparation tank at once without separating the two.
또한 쓴맛 마스킹 성분(a)과, 쓴맛 마스킹 보조성분(b)과, 응집 억제 겔화 성분(c)과, 수분(e)의 적어도 일부의 혼합 순서는, 특별히 한정되지 않고, 이들(a,b,c 및 e)을 혼합하여 얻어진 혼합물 중에, 맛조정 성분(d)을 첨가하여 혼합하면 좋다The order of mixing at least a portion of the bitterness masking component (a), the bitterness masking auxiliary component (b), the aggregation inhibiting gelling component (c), and the moisture (e) is not particularly limited, and these (a, b, What is necessary is just to add and adjust a taste adjustment component (d) in the mixture obtained by mixing c and e).
약복용 입상 젤리 음료를 제조하는 방법에 있어서, 쓴맛 마스킹 성분(a)과, 쓴맛 마스킹 보조 성분(b)과, 응집 억제 겔화 성분(c)과, 수분(e)의 적어도 일부를 대략 균일하게 혼합하여 혼합물을 얻은 후, 상기 혼합물에, 맛조정 성분(d)을 혼합하는 것에 의해서, 입상 젤리 음료에 응집 등이 생기기 어려워져, 생약이나 한방약 등을 감싸는데 매우 적합한 형태를 갖는 입상 젤리 음료를 제조할 수 있다.A method for producing a granular jelly drink for medicine, wherein the bitter masking component (a), the bitter masking auxiliary component (b), the aggregation inhibiting gelling component (c), and at least a part of the water (e) are mixed approximately uniformly. After the mixture is obtained, by mixing the taste adjusting component (d) with the mixture, it becomes difficult to cause coagulation or the like in the granular jelly beverage, thereby preparing a granular jelly beverage having a form that is very suitable for wrapping crude medicine, herbal medicine, and the like. can do.
약복용 입상 젤리 음료는, 생약이나 한방약 등의 쓴맛과 함께 신맛을 나타내는 약제를 복용할 때에 매우 적합하게 이용할 수 있다. 복용 방법으로는 예를 들면 생약이나 한방약 등의 약제를 입속에 넣은 후에, 약복용 입상 젤리 음료를 물 대신에 입속에 넣고, 약제와 약복용 입상 젤리 음료를 인후에 흘려 넣어 삼켜도 좋다. 또한, 미리, 컵 등의 용기 등에 넣은 약복용 입상 젤리 음료 중에, 약제를 넣고 혼합하여, 이 혼합물을 삼켜도 좋다.The granular jelly drink for medicine can be used suitably when taking the medicine which shows a sour taste with bitter tastes, such as a herbal medicine and a herbal medicine. As a method of taking, for example, a medicine such as a herbal medicine or an herbal medicine may be put in the mouth, and then the medicine granulated jelly drink may be put in the mouth instead of water, and the medicine and medicine granulated jelly drink may be poured into the throat and swallowed. In addition, you may mix and put a chemical | medical agent in the granular jelly drink for medicines previously put in containers, such as a cup, and swallow this mixture.
[실시예][Example]
이하, 본 발명을 실시예 및 비교예에 의거하여 더욱더 상세하게 설명하지만, 본 발명은 이들 실시예로 한정되는 것은 아니다. Hereinafter, although this invention is demonstrated further in detail based on an Example and a comparative example, this invention is not limited to these Examples.
(실시예 1)(Example 1)
도1에 나타내는 제조방법에 따라, 소르비톨, 덱스트란을 가온(약 50℃)한 물(50부)에 첨가하여 수온을 50℃로 유지한 채로, 추가로 대두 레시틴을 첨가하여 교반했다. 다음에, 미리 가온한 물(20부)에 용해한 잔탄 검을 서서히 첨가하여 교반하고, 혼합물을 얻었다. 이 혼합물에 구연산을 첨가하여 교반하고, 추가로 향료와 물을 첨가하여, 전량을 조제하고, 용기에 충전한 후, 냉각하여 약복용 입상 젤리 음료를 얻었다. 각 성분의 배합 비율을 표 1에 나타냈다.According to the manufacturing method shown in FIG. 1, soybean lecithin was further added and stirred while adding sorbitol and dextran to warmed water (50 parts) and maintaining the water temperature at 50 ° C. Next, the xanthan gum dissolved in the water (20 parts) previously heated was gradually added and stirred, and the mixture was obtained. Citric acid was added and stirred to this mixture, the fragrance and water were further added, the whole quantity was prepared, it filled into the container, and it cooled, and obtained the granule jelly drink for medicines. The compounding ratio of each component was shown in Table 1.
약복용 입상 젤리 음료의 pH는 4.2, 젤리 강도는 40.0g/㎠, 입상 젤리의 최대길이는 5.0mm, 수분 감소율은 0.5%이었다.The pH of the granular jelly drink for medicine was 4.2, the jelly strength was 40.0 g / cm 2, the maximum length of the granular jelly was 5.0 mm, and the water reduction rate was 0.5%.
또한 젤리 강도는 후술하는 방법에 의해 측정했다.In addition, the jelly strength was measured by the method of mentioning later.
(실시예2)Example 2
도 2에 나타내는 제조방법에 따라, 에리스리톨(erythritol), 소르비톨을 가온(약 50℃)한 물(50부)에 첨가하여 수온을 50℃로 유지한 채로, 추가로 카카오 유지를 첨가하여 교반하고, 혼합물(제1의 혼합물)을 얻었다. 다음에, 미리 가온(약 50℃)한 물(20부)에 한천, 로카스트 콩 검(locust bean gum), 수크로오스 지방산 에스테르를 첨가하여 교반하고, 혼합물을 얻은 후, 이 혼합물을, 제1의 혼합물에 서서히 첨가해 교반하고, 제2의 혼합물을 얻었다. 그 후, 제2의 혼합물에 구연산을 첨가하여 교반하고, 추가로 향료와 물을 첨가하고, 전량을 조제하고, 용기에 충전한 후, 냉각하여 약복용 입상 젤리 음료를 얻었다. 각 성분의 배합 비율을 표 2에 나타냈다.According to the manufacturing method shown in FIG. 2, erythritol and sorbitol were added to the heated (about 50 degreeC) water (50 parts), and cacao fat was further added and stirred, maintaining water temperature at 50 degreeC, A mixture (first mixture) was obtained. Next, agar, locust bean gum, and sucrose fatty acid ester were added to water (20 parts) that had been warmed (about 50 ° C.) and stirred, and a mixture was obtained. The mixture was slowly added and stirred to obtain a second mixture. Thereafter, citric acid was added to the second mixture, followed by stirring. Further, perfume and water were added, the whole amount was prepared, filled into a container, and then cooled to obtain a granular jelly drink for medicine. The compounding ratio of each component was shown in Table 2.
또한 약복용 입상 젤리 음료의 pH는 3.3, 젤리 강도는 45.5g/㎠, 입상 젤리의 최대길이는 5.0mm, 수분 감소은 2.0%이었다.
In addition, the pH of the granular jelly drink for medicine was 3.3, the jelly strength was 45.5 g / cm 2, the maximum length of the granular jelly was 5.0 mm, and the water loss was 2.0%.
(비교예) (Comparative Example)
에리스리톨(erythritol), 환원 맥아당 물엿, 로카스트 콩 검, 잔탄검, 카라기난 및 락트산 칼슘을 가온(약 50℃)한 물(50부)에 첨가하고, 수온을 50℃로 유지한 채로 균질화한 수크로오스 지방산 에스테르와 카카오 유지를 첨가하여 교반하고, 추가로 향료와 감미료와 물을 첨가하고, 전량을 조제하고, 용기에 충전한 후, 냉각하여, 맛 조정 성분을 포함하지 않는 쓴맛 마스킹 입상 젤리를 얻었다. 각 성분의 배합 비율을 표 3에 나타냈다.Sucrose fatty acid homogenized while adding erythritol, reduced maltose syrup, locust bean gum, xanthan gum, carrageenan and calcium lactate to warmed (about 50 ° C) water (50 parts) and maintaining the water temperature at 50 ° C. Ester and cacao fat were added and stirred, further flavors, sweeteners and water were added, the whole amount was prepared, filled into a container, and cooled, and the bitterness masking granular jelly which does not contain a taste adjustment component was obtained. The blending ratio of each component is shown in Table 3.
또한 쓴맛 마스킹 입상 젤리 음료의 pH는 6.6, 젤리 강도는 39.8g/㎠, 입상 젤리의 최대길이는 5.0 mm, 수분감소율은 1.8% 이었다.In addition, the pH of the bitter masking granular jelly beverage was 6.6, the jelly strength was 39.8 g / cm 2, the maximum length of the granular jelly was 5.0 mm, and the moisture reduction rate was 1.8%.
(참고예)(Reference example)
도 1에 나타내는 제조 방법에 의해, 에리스리톨(erythritol), 자일리톨 및 한천을 가온(약 50℃)한 물(50부)에 첨가하고 수온을 50℃로 유지한 채로, 추가로 대두 레시틴을 첨가하여 교반하였다. 다음에, 미리 가온한 물(20부)에 수크로오스 지방산 에스테르를 서서히 첨가하고 교반하여, 혼합물을 얻었다. 이 혼합물에 구연산을 첨가한 경우에, 덩어리상(lump)이 형성되며, 혼합물을 교반하더라도 용해할 수 없었다. 즉, 본 참고예에서는, 응집 억제 겔화 성분을 함유하고 있지 않기 때문에, 응집이 생겨 적당한 겔을 형성할 수 없었다. 본 예의 각 성분의 배합 비율을 표 4에 나타냈다.By the manufacturing method shown in FIG. 1, erythritol, xylitol, and agar were added to the heated (about 50 degreeC) water (50 parts), and soybean lecithin was further added and stirred, maintaining the water temperature at 50 degreeC. It was. Next, sucrose fatty acid ester was gradually added to the water (20 parts) previously heated and stirred to obtain a mixture. When citric acid was added to this mixture, a lump was formed and could not be dissolved even if the mixture was stirred. That is, in this reference example, since it did not contain the aggregation inhibiting gelling component, aggregation occurred and an appropriate gel could not be formed. Table 4 shows the blending ratios of the components of the present example.
[젤리 강도의 측정] [Measurement of Jelly Strength]
측정 장치: 레오 미터(레오텍사 제조 형식 RT-2020J)Measuring device: Rheometer (Leotec manufactured model RT-2020J)
플런저: 1cmφPlunger: 1cmφ
압축 속도: 2cm/minCompression Speed: 2cm / min
측정 방법:How to measure:
시료를 20℃에서 15시간 이상 방치한 후, 젤리를 파괴하지 않도록 꺼내고, 적당한 용기(3cmφ×2cm)로 시료가 손실되지 않게 주의하여 꺼내고, 상술한 측정장치를 이용하여, 시료의 강도를 측정하고, 하기식(1)을 이용하여, 젤리 강도를 산출했다.After leaving the sample at 20 ° C. for 15 hours or more, the sample was taken out so as not to destroy the jelly, and carefully taken out so as not to lose the sample in a suitable container (3 cmφ × 2 cm), and the strength of the sample was measured using the measuring device described above. And jelly strength were computed using following formula (1).
젤리 강도(g/㎠) = 측정 강도(g)/0.785(㎠) (1)Jelly strength (g / cm 2) = Measurement strength (g) / 0.785 (cm 2) (1)
또한 0.785㎠는 플런저(plunger)의 표면적이다.0.785 cm 2 is the surface area of the plunger.
[성능 평가] [Performance evaluation]
각 예의 입상 젤리 음료를, 하기의 사람 관능 시험에 제공하여, 얻어진 결과를 표 4~10에 나타냈다.
The granular jelly drink of each case was provided to the following human sensory test, and the obtained result was shown to Tables 4-10.
(관능 시험 조건) (Sensory test conditions)
이하에 나타낸 바와 같이, 소정량의 한방처방에 의한 대상 약제를, 소정량의 각 예의 입상 젤리 음료로 처리하고, 얻어진 시료(한방약 함유 입상 젤리 음료)를 6명의 피험자(정상 성인; 남성 5명, 여성 1명)에게 복용시켜, 소정의 시간에서의 각 미각을 다음과 같이 평가했다.As shown below, a predetermined amount of the target medicine by herbal prescription was treated with a predetermined amount of granular jelly drink of each case, and six samples (normal adults; 5 males) were obtained from the sample (oral medicine containing granular jelly drink). 1 woman) and each taste at a predetermined time was evaluated as follows.
또한 단맛의 경우는, 한방약 단독과 차이가 없는 경우를 「△」, 단맛이 약간 강해지는 경우를 「○」, 단맛이 강해지는 경우를 「◎」이라고 했다.In addition, in the case of sweetness, "(circle)" and the case where sweetness became a little strong were "(circle)", and the case where sweetness became strong was "◎" when there was no difference with an herbal medicine alone.
쓴맛의 경우는, 한방약 단독과 차이가 없는 경우를 「△」, 쓴맛이 약간 적게 되는 경우를 「○」, 쓴맛이 없는 경우를 「◎」 이라고 했다.In the case of bitterness, the case where there was no difference with the herbal medicine alone was "△", and the case where bitterness was slightly reduced was "○" and the case where there was no bitterness was "◎".
신맛의 경우는, 한방약보다 신맛이 약해지는 경우를 「×」, 한방약 단독과 차이가 없는 경우를 「△」, 신맛이 약간 강해지는 경우를 「○」, 신맛이 강해지는 경우를 「◎」 이라고 했다.In the case of sourness, the case where the sourness becomes weaker than the herbal medicine is "x", the case where there is no difference with the herbal medicine alone is "△", and the case where the acidity becomes slightly stronger is "○", and the case where the sourness becomes strong is "◎". did.
매운맛의 경우는, 한방약 단독과 차이가 없는 경우를 「△」, 매운맛이 약간 적게 되는 경우를 「○」, 매운맛이 없는 경우를 「◎」 이라고 했다.In the case of spicy, the case where there was no difference with the herbal medicine alone was "△", and the case where the spicy taste became slightly smaller was "(circle)" and the case where there was no spicy was "◎".
또한, 악취로서 한방 취가 있는 경우를 「△」, 한방 취가 약간 있는 경우를 「○」, 한방 취가 없는 경우를 「◎」 이라고 했다.In addition, "(circle)" and the case where there is a slight odor are "(circle)" and the case where there is no odor as "odor" was called "(circle)".
또한, 향료의 악취로서 향료 취가 있는 경우를 「△」, 향료 취가 약간 있는 경우를 「○」, 향료 취가 없는 경우를 「◎」 이라고 했다.
In addition, "(circle)" and the case where there is a fragrance odor were "(circle)" and the case where there was no fragrance odor was "◎" as a smell of a fragrance.
(1) 대상 약제(1) Target drug
(가) 황련해독탕(黃連解毒湯) 엑기스 과립(쓰무라사 제조 No.15)(A) Hwangnyeonhaedoktang Extract Granules (Tsumura Co., Ltd. No.15)
(나) 소풍산(消風散) 엑기스 과립(쓰무라사 제조 No.22)(B) Sopungsan Extract Granules (Tsumura Co., Ltd. No. 22)
(다) 오수유탕(吳茱萸湯) 엑기스 과립(쓰무라사 제조 No.31)(C) Osuyu-tang extract granules (Tsumura Co., Ltd. No.31)
(라) 온청음(溫淸飮) 엑기스 과립(쓰무라사 제조 No.57)(D) Warm-noise extract granules (Tsumura Corporation No. 57)
(마) 치두창일방(治頭瘡一方) 엑기스 과립(쓰무라사 제조 No.59)(E) Chivalin unilateral extract granules (Tsumura company No. 59)
(바) 시호청간탕(柴胡淸肝湯) 엑기스 과립(쓰무라사 제조 No.80)(E) Shihocheonggantang Extract Granules (Tsumura Co., Ltd. No. 80)
(사) 시령탕(柴笭湯) 엑기스 과립(쓰무라사 제조 No.114)Shiryeongtang Extract Granules (Tsumura Corporation No. 114)
(2) 약제 량 (2) drug amount
각각 1.25 g으로 했다.
Each was 1.25 g.
(3) 시료의 조제(3) Preparation of Sample
입상 젤리 음료 10g에 약제 1.25g를 첨가하여 잘 섞었다.To 10 g of granular jelly drink, 1.25 g of the drug was added and mixed well.
약제를 첨가하여 잘 혼합한 젤리를 입에 넣고, 10초 후에 뱉어내어, 5초 후에 피험자에게 평가받았다.Jelly mixed well by adding the agent was put in the mouth, spit out after 10 seconds, and evaluated by the subject after 5 seconds.
[성능 평가의 고찰] [Consideration of performance evaluation]
표 5~11에 나타낸 바와 같이, 본 실시예 1,2의 약복용 입상 젤리 음료는, 한방약(가)~(사)와 함께 복용했을 경우에, 단맛와 신맛이 강해지는 경향이 있고, 이 경향에 의해서 쓴맛이 있었다고 해도 한방약이 마시기 어려워지는 쓴맛은 되지 않고 , 오히려 쓴맛과 매운맛이 약해지는 경향이 있으며, 한방약이 마시기 쉬워져 있었다. 또한, 본 실시예의 약복용 입상 젤리를 이용함으로써, 한방 취도 없어져 미각을 향상시키고, 보다 삼키기 쉬워진 것을 확인할 수 있었다.As shown in Tables 5-11, when the granular jelly drink for medicines of Examples 1 and 2 is taken together with herbal medicines (A) to (G), sweetness and sourness tend to be strong, Even if there was a bitter taste, the herbal medicine becomes hard to drink, it does not become a bitter taste, but rather, the bitterness and spicy tend to become weak, and the herbal medicine became easy to drink. In addition, it was confirmed that by using the granular jelly for medicine of the present example, no herbal odor was lost, the taste was improved, and it was easier to swallow.
한편, 비교예(종래의 쓴맛 마스킹 입상 젤리 음료)는, 신맛이나 매운맛이 한방약 그 자체와 상위하지 않고, 한방 취도 잔존하고 있으며, 한방약의 복용에는 적합하지 않았다On the other hand, the comparative example (conventional bitter masking granular jelly drink) does not differ from the herbal medicine itself in acidity and spicy taste, and the herbal odor remains, and it was not suitable for taking the herbal medicine
[산업상의 이용가능성] [Industrial Availability]
본 발명에 의하면, 쓴맛 마스킹 성분과 쓴맛 마스킹 보조 성분과 맛 조정 성분을 이용함과 동시에, 응집 억제 겔화 성분을 이용함으로써, 생약 및/또는 한방약의 약효를 떨어트리는 일 없이, 이들 약제의 쓴맛을 마스킹하여, 삼키기 쉽게 약제를 감쌀 수 있는 한편, 생약 및/또는 한방약으로 이루어진 약제와의 혼합 후에도 양호한 미각을 나타내는 약복용 입상 젤리 음료 및 그 제조 방법을 제공할 수 있다.
According to the present invention, by using a bitter masking component, a bitter masking auxiliary component and a taste adjusting component, and by using an aggregation inhibitory gelling component, masking the bitter taste of these drugs without degrading the efficacy of the herbal medicine and / or herbal medicine It is possible to provide a medicine-coated granular jelly beverage which can be wrapped easily with a medicine and exhibits a good taste even after mixing with a medicine consisting of a herbal medicine and / or a herbal medicine and a method for producing the same.
Claims (12)
(a) 식물유지 및/또는 동물유지로 이루어진 쓴맛 마스킹 성분 0.1~15.0 질량%과,
(b) 당 알코올로 이루어진 쓴맛 마스킹 보조 성분 5.0~20.0 질량%과,
(c) 카라기난, 젤란 검, 로카스트 콩 검, 잔탄 검, 구아 검, 펙틴, 타피오카 전분 및 전분으로 이루어진 군에서 선택된 적어도 1종의 응집 억제 겔화 성분 0.1~5.0 질량%과,
(d) 산, 그의 유도체 및 그의 염으로 이루어진 군에서 선택된 적어도 1종의 맛조정 성분 0.1~5.0 질량%과,
(e) 잔량으로서 수분을 함유하는 것을 특징으로 하는 약복용 입상 젤리 음료.
As a granular jelly drink for medicine used for taking herbal medicine and / or herbal medicine,
(a) 0.1-15.0 mass% of a bitter masking component consisting of vegetable oil and / or animal oil,
(b) 5.0-20.0 mass% of bitterness masking auxiliary component consisting of sugar alcohol,
(c) 0.1-5.0 mass% of at least one aggregation inhibitory gelling component selected from the group consisting of carrageenan, gellan gum, locust bean gum, xanthan gum, guar gum, pectin, tapioca starch and starch,
(d) 0.1 to 5.0% by mass of at least one flavor adjusting component selected from the group consisting of an acid, a derivative thereof and a salt thereof,
(e) A granular jelly beverage for medicines, characterized in that it contains water as a residual amount.
(c-1) 한천, 퍼셀라란, 젤라틴, 커드란, 사일리움시드검, 알긴산, 알긴산염, 만난, 타마린드검, 덱스트란, 카르복시메틸 셀룰로오스, 카르복시메틸 셀룰로오스 나트륨 및 메틸 셀룰로오스로 이루어진 군에서 선택된 적어도 1종의 겔화 성분을 포함하는 것을 특징으로 하는 약복용 입상 젤리 음료.The method of claim 1,
(c-1) in the group consisting of agar, percelanan, gelatin, curdlan, siliumseed gum, alginic acid, alginate, mannan, tamarind gum, dextran, carboxymethyl cellulose, carboxymethyl cellulose sodium and methyl cellulose A granular jelly beverage for medicines comprising at least one gelling ingredient selected.
상기 응집 억제 겔화 성분 (c) 및 겔화 성분(c-1)의 전량 중에, 응집 억제 겔화 성분 2.0~100.0 질량%를 함유하는 것을 특징으로 하는 약복용 입상 젤리 음료.
The method of claim 2,
The granular jelly drink for medicines containing 2.0-100.0 mass% of aggregation suppression gelling components in the whole quantity of the said aggregation suppression gelling component (c) and gelling component (c-1).
pH가 2.5~5.0인 것을 특징으로 하는 약복용 입상 젤리 음료.
4. The method according to any one of claims 1 to 3,
Granular jelly drink for medicines, characterized in that the pH is 2.5 ~ 5.0.
(f)수크로오스 지방산 에스테르, 글리세린 지방산 에스테르, 소르비탄 지방산 에스테르, 프로필렌 글리콜 및 프로필렌 글리콜 지방산 에스테르로 이루어진 군에서 선택된 적어도 1종의 발수 억제 성분을 0.01~1.5 질량% 함유하는 것을 특징으로 하는 약복용 입상 젤리 음료.
The method according to any one of claims 1 to 4,
(f) Granules for medicines, characterized in that it contains 0.01-1.5 mass% of at least one water repellent inhibitor component selected from the group consisting of sucrose fatty acid ester, glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol and propylene glycol fatty acid ester. Jelly drink.
입상 젤리의 20℃에서의 젤리 강도가 10~100g/㎠인 것을 특징으로 하는 약복용 입상 젤리 음료.
The method according to any one of claims 1 to 5,
A granular jelly drink for medicines, characterized in that the jelly strength at 20 ° C. of the granular jelly is 10 to 100 g / cm 2.
입상 젤리의 최대 길이가 1~10mm인 것을 특징으로 하는 약복용 입상 젤리 음료.
The method according to any one of claims 1 to 6,
A granular jelly drink for medicines, characterized in that the maximum length of the granular jelly is 1 to 10 mm.
상기 쓴맛 마스킹 성분(a)의 식물유지가 카카오 유지, 레시틴, 대두유, 샐러드유, 식용 새플라워유, 해바라기유, 유채씨유, 옥수수유, 쌀 기름, 낙화생유, 올리브유, 참기름, 아마인유, 코코넛유, 팜유, 야자유, 혼합유, 마가린 및 쇼트닝으로 이루어진 군에서 선택된 적어도 1종의 것이며, 동물유지가, 라드, 무염 버터, 버터, 치즈, 크림, 육지방 및 어유로 이루어진 군에서 선택된 적어도 1종의 것임을 특징으로 하는 약복용 입상 젤리 음료.
The method according to any one of claims 1 to 7,
The vegetable oil of the bitter masking component (a) is cacao oil, lecithin, soybean oil, salad oil, edible sunflower oil, sunflower oil, rapeseed oil, corn oil, rice oil, peanut oil, olive oil, sesame oil, linseed oil, coconut At least one selected from the group consisting of oil, palm oil, palm oil, mixed oil, margarine and shortening, and at least one selected from the group consisting of lard, unsalted butter, butter, cheese, cream, land fat and fish oil Granular jelly drink for medicines, characterized in that of.
상기 쓴맛 마스킹 보조 성분(b)의 당 알코올이, 환원 맥아당 물엿, 환원 물엿, 환원 유당, 자일리톨, 에리스리톨(erythritol), 소르비톨 및 만니톨로 이루어진 군에서 선택된 적어도 1종의 것임을 특징으로 하는 약복용 입상 젤리 음료.
The method according to any one of claims 1 to 8,
The sugar alcohol of the bitterness masking auxiliary component (b) is at least one granular jelly, characterized in that at least one selected from the group consisting of reduced maltose syrup, reduced syrup, reduced lactose, xylitol, erythritol, sorbitol and mannitol. beverage.
상기 맛 조정 성분(d)이, 아디핀산, L-아스코르빈산, L-아스파라긴산, L-아르기닌 L-글루타민산, 구연산, 글루코노 델타 락톤, 글루콘산, 숙신산, DL-타타르산, L-타타르산, 락트산, 프말산, 부티르산, DL-말릭산, 이들의 유도체 및 이들의 염으로 이루어진 군에서 선택된 적어도 1종의 것임을 특징으로 하는 약복용 입상 젤리 음료.
The method according to any one of claims 1 to 9,
The taste adjustment component (d) is adipic acid, L-ascorbic acid, L-aspartic acid, L-arginine L-glutamic acid, citric acid, glucono delta lactone, gluconic acid, succinic acid, DL-tartaric acid, L-tartaric acid Cosmetic granular jelly drink, characterized in that at least one selected from the group consisting of lactic acid, fric acid, butyric acid, DL- malic acid, derivatives thereof and salts thereof.
상기 생약 및/또는 한방약이 산제, 과립제, 환제, 캅셀제, 분말 엑기스제, 정제, 엑기스제 및 시럽제로 이루어진 군에서 선택된 적어도 1종의 제제인 것을 특징으로 하는 약복용 입상 젤리 음료.
The method according to any one of claims 1 to 10,
The herbal medicine and / or herbal medicine is granular jelly drink for medicine, characterized in that at least one agent selected from the group consisting of powders, granules, pills, capsules, powder extracts, tablets, extracts and syrups.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2007/069934 WO2009047859A1 (en) | 2007-10-12 | 2007-10-12 | Granular jelly beverage for medication and process for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20100084622A true KR20100084622A (en) | 2010-07-27 |
| KR101465836B1 KR101465836B1 (en) | 2014-11-26 |
Family
ID=40549014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107007952A KR101465836B1 (en) | 2007-10-12 | 2007-10-12 | Granular jelly beverage for medication and process for producing the same |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9084741B2 (en) |
| EP (1) | EP2201956B1 (en) |
| JP (1) | JP5249941B2 (en) |
| KR (1) | KR101465836B1 (en) |
| CN (1) | CN101820893A (en) |
| AU (1) | AU2007360026B9 (en) |
| CA (1) | CA2701777C (en) |
| DK (1) | DK2201956T3 (en) |
| ES (1) | ES2472297T3 (en) |
| TW (1) | TWI405587B (en) |
| WO (1) | WO2009047859A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019117506A1 (en) * | 2017-12-12 | 2019-06-20 | 주식회사 삼양사 | Low-caloric beverage |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3210597A1 (en) | 2010-09-13 | 2017-08-30 | Bev-RX, Inc. | Aqueous drug delivery system comprising off- flavor masking agent |
| EP2641477B2 (en) | 2012-03-19 | 2022-06-08 | Symrise AG | Compositions of matter |
| JP5955615B2 (en) * | 2012-04-10 | 2016-07-20 | 三栄源エフ・エフ・アイ株式会社 | Weakly acidic protein-containing gel food and drink |
| CN103005552A (en) * | 2012-11-02 | 2013-04-03 | 西华大学 | Preparation method of olive oil drink |
| CN103083458A (en) * | 2013-01-21 | 2013-05-08 | 康美药业股份有限公司 | Warm light drink compound formula granule, as well as preparation method as well as detection method thereof |
| JP6549428B2 (en) * | 2014-07-23 | 2019-07-24 | エスエス製薬株式会社 | Oral composition |
| KR102131421B1 (en) * | 2014-12-15 | 2020-07-08 | (주)산엔들 | Making method of jelly comprising medical herb powder |
| GB201512728D0 (en) * | 2015-07-20 | 2015-08-26 | Isis Innovation | Nanoencapsulated oxygen |
| JP2018000402A (en) * | 2016-06-30 | 2018-01-11 | 静岡県 | Tongue cover |
| JP7217083B2 (en) * | 2016-12-28 | 2023-02-02 | ポッカサッポロフード＆ビバレッジ株式会社 | JELLY BEVERAGE AND METHOD FOR MANUFACTURING JELLY BEVERAGE |
| US11304433B2 (en) * | 2017-08-08 | 2022-04-19 | eBIO Nutritional Sciences LLC | Sweetener composition and methods of making it |
| JP2019069914A (en) * | 2017-10-06 | 2019-05-09 | 松浦薬業株式会社 | Chinese medicine pharmaceutical composition and chinese medicine preparation |
| WO2021038280A1 (en) * | 2019-08-30 | 2021-03-04 | Procaps S.A. | Chewable heat-resistant oral dosage form with an agar matrix and production method for obtaining the chewable oral dosage form |
| KR20220086643A (en) | 2019-10-25 | 2022-06-23 | 스미또모 가가꾸 가부시키가이샤 | food composition |
| CN110840825A (en) * | 2019-11-13 | 2020-02-28 | 长春雷允上药业有限公司 | Gel composition, preparation method and application thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2783890B2 (en) | 1990-03-08 | 1998-08-06 | 東京電力株式会社 | Laser oscillator |
| JP2508555B2 (en) * | 1991-05-24 | 1996-06-19 | 株式会社紀文食品 | Bitterness reduction method |
| JPH07115942A (en) | 1993-08-09 | 1995-05-09 | Sanji Kumai | Production of oligo drink and oligo jelly of herb medicine |
| RU2150942C1 (en) * | 1993-10-01 | 2000-06-20 | Синтекс (Ю.ЭС.ЭЙ.) Инк. | Oral suspension containing high dose of mofetil mycophenolate |
| US5576039A (en) * | 1995-02-03 | 1996-11-19 | Bush Boake Allen Inc. | Colored jelly-type substance, method of preparation, and composition containing same |
| JP4309481B2 (en) * | 1996-01-12 | 2009-08-05 | テイコクメディックス株式会社 | Jelly oral pharmaceutical composition |
| JP3257983B2 (en) * | 1997-07-31 | 2002-02-18 | 株式会社龍角散 | Drug swallowing aid drink |
| US6277395B1 (en) * | 1998-07-31 | 2001-08-21 | Ryukakusan Co. Ltd. | Swallowing-assistive drink |
| BR9907989A (en) * | 1998-01-30 | 2002-02-05 | Procter & Gamble | Drinks with improved texture and flavor impact with low solids dosages |
| JP4555407B2 (en) | 1998-05-06 | 2010-09-29 | 伊那食品工業株式会社 | Kampo medicines and herbal medicines |
| JP3583723B2 (en) * | 2001-01-23 | 2004-11-04 | 三栄源エフ・エフ・アイ株式会社 | Gel composition in which insoluble solid is dispersed and its application |
| JP4057835B2 (en) | 2002-05-01 | 2008-03-05 | エスケー化研株式会社 | Method for producing inorganic pigment |
| CA2538755C (en) | 2003-09-12 | 2013-04-16 | Ryukakusan Co. Ltd. | Granular jelly drink capable of masking bitterness |
| CA2592155C (en) * | 2004-12-24 | 2013-12-17 | Ryukakusan Co., Ltd. | Process for producing jellylike drink |
-
2007
- 2007-10-12 US US12/682,747 patent/US9084741B2/en active Active
- 2007-10-12 ES ES07829670.4T patent/ES2472297T3/en active Active
- 2007-10-12 DK DK07829670.4T patent/DK2201956T3/en active
- 2007-10-12 KR KR1020107007952A patent/KR101465836B1/en active IP Right Grant
- 2007-10-12 JP JP2009536899A patent/JP5249941B2/en active Active
- 2007-10-12 CN CN200780101058A patent/CN101820893A/en active Pending
- 2007-10-12 EP EP07829670.4A patent/EP2201956B1/en active Active
- 2007-10-12 CA CA2701777A patent/CA2701777C/en active Active
- 2007-10-12 WO PCT/JP2007/069934 patent/WO2009047859A1/en active Application Filing
- 2007-10-12 AU AU2007360026A patent/AU2007360026B9/en active Active
-
2008
- 2008-01-28 TW TW097103029A patent/TWI405587B/en active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019117506A1 (en) * | 2017-12-12 | 2019-06-20 | 주식회사 삼양사 | Low-caloric beverage |
| US11779035B2 (en) | 2017-12-12 | 2023-10-10 | Samyang Corporation | Low-caloric beverage |
Also Published As
| Publication number | Publication date |
|---|---|
| DK2201956T3 (en) | 2014-07-14 |
| CA2701777A1 (en) | 2009-04-16 |
| CN101820893A (en) | 2010-09-01 |
| TW200916124A (en) | 2009-04-16 |
| AU2007360026B2 (en) | 2013-06-20 |
| KR101465836B1 (en) | 2014-11-26 |
| WO2009047859A1 (en) | 2009-04-16 |
| AU2007360026A1 (en) | 2009-04-16 |
| JPWO2009047859A1 (en) | 2011-02-17 |
| US9084741B2 (en) | 2015-07-21 |
| EP2201956A1 (en) | 2010-06-30 |
| TWI405587B (en) | 2013-08-21 |
| AU2007360026B9 (en) | 2013-07-11 |
| EP2201956B1 (en) | 2014-04-30 |
| CA2701777C (en) | 2015-04-21 |
| ES2472297T3 (en) | 2014-06-30 |
| JP5249941B2 (en) | 2013-07-31 |
| EP2201956A4 (en) | 2012-08-29 |
| US20100239684A1 (en) | 2010-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101465836B1 (en) | Granular jelly beverage for medication and process for producing the same | |
| US8287897B2 (en) | Bitterness-masking particulate jelly beverage | |
| JP6370258B2 (en) | Body odor improving agent for ingestion in body, food and drink using the same, and method for improving body odor | |
| US20090130211A1 (en) | Gelled colloidal emulsion for appetite suppression | |
| JP4264105B2 (en) | Isosorbide-containing jelly preparation | |
| JP2001226293A (en) | Taking assisting agent | |
| JP5106948B2 (en) | Oral administration adjuvant composition for pets | |
| JP2012010608A (en) | Propolis containing candy | |
| JP4216447B2 (en) | Swallowing aid | |
| JP6758619B2 (en) | Composition | |
| CA2939330C (en) | Serum cholesterol lowering edible product | |
| JP2006320223A (en) | Thiamin-containing food reinforced in vitamin c |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| AMND | Amendment | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| AMND | Amendment | ||
| J201 | Request for trial against refusal decision | ||
| B701 | Decision to grant | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20171018 Year of fee payment: 4 |
|
| FPAY | Annual fee payment |
Payment date: 20181018 Year of fee payment: 5 |