JP3257983B2 - Drug swallowing aid drink - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a swallowing aid for a drug, and more particularly to a drug for swallowing a variety of diseases, frail constitutions, and even a healthy person who suffers from pain (such as bitterness) while taking the drug. The present invention relates to a swallowing auxiliary drink that facilitates or promotes swallowing of a drug without giving difficulty, a foreign body sensation, etc. to patients, children, and the elderly who have difficulty swallowing the drug with ordinary drinking water when taking the drug.

[0002]

2. Description of the Related Art Conventionally, medicines are usually taken with water or tea. However, with such water or tea, patients who have difficulty swallowing, especially the elderly, etc., have difficulty in taking the drug, and when taking the drug in the form of powders, granules and tablets, they can swallow sufficiently. Not only did they throat rather than stay in the mouth or stayed in the oral cavity, they could not only obtain a sufficient therapeutic effect, but also the patients themselves felt uncomfortable. For this reason, crushing tablets, foods, for example, rice, miso soup and juice were also taken and taken, but it is troublesome and cumbersome,
Furthermore, the desired medicinal effect may not be obtained due to the inability to adjust the release time of the drug component or the masking of the taste due to the pulverization of the tablet.

[0003] On the other hand, in the form of pharmaceuticals, small tablets, jelly dosage forms, orally disintegrating tablet forms and the like have been devised. In foods, liquid foods (such as miso soup)
There is a commercially available powder for adding a liquid food, which makes it easier to swallow a liquid food by adding a torsion to the liquid.

[0004]

However, the above-described invented dosage form does not always provide a sufficient effect, and although there are swallowing agents for liquid foods, swallowing for improving swallowing for various drugs is available. There has been a problem that an improving agent has not been developed yet.

The present invention has been made in view of the above-mentioned problems of the prior art, and it is an object of the present invention to improve the swallowing of various drugs and to provide a simple and easy replacement for ordinary drinking water. Another object of the present invention is to provide a swallowing auxiliary drink for a drug which does not inhibit the drug effect.

[0006]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have conducted various studies on drinks which facilitate swallowing of medicines when taking the medicines, and as a result, mixing a specific paste with water, It has been found that the above problems can be solved by adjusting the viscosity or the jelly strength, and the present invention has been completed.

[0007] That is, the swallowing auxiliary drink of the present invention is taken together with a drug (however, excluding a seamless capsule containing a medicinal ingredient, a powder and fine granules) to facilitate swallowing of the drug and does not inhibit the medicinal effect. A low-calorie non-sugar swallowing aid beverage for people with dysphagia, comprising:
0-99.9% by weight and agar, carrageenan, gellan gum, furceleran, gelatin, pectin, curdlan, locust bean gum, tara gum, guar gum,
At least one paste selected from the group consisting of xanthan gum, alginic acid, alginates, Azotobacter vinelandi gum, cassia gum, silium seed gum, tamarind gum, CMCNa, CMCCa, whey protein, starch and modified starch. In the form of a viscous liquid having a viscosity at 20 ° C. of 1000 to 25
000 cP.

[0008] Further, another swallowing auxiliary beverage of the present invention is taken together with a drug (however, excluding a seamless capsule containing a medicinal ingredient, a powder and fine granules) to facilitate swallowing of the drug and to improve the medicinal effect. A low-calorie non-sugar swallowing auxiliary drink for people with dysphagia that does not inhibit water content of 8
0.0 to 99.9% by weight and agar, carrageenan, gellan gum, furceleran, gelatin, pectin, curdlan, locust bean gum, tara gum, guar gum, xanthan gum, alginic acid, alginate, azotobacter vinelandi gum, cassia gum , Silium seed gum, tamarind gum, CMCNa, CMCC
a) containing at least one kind of paste selected from the group consisting of whey protein, starch and modified starch in an amount of 0.1 to 5.0% by weight, and having a gel-like state and a jelly strength at 20 ° C of 10 to 10%.
It is characterized by being 100 g / cm ² .

[0009]

The swallowing aid beverage of the present invention has an appropriate jelly strength or viscosity. Therefore, not only healthy people, but also patients who have difficulty swallowing the drug due to weak constitution or various diseases, etc., using the swallowing auxiliary drink of the present invention, without affecting the efficacy of various drugs. You will be able to swallow easily.

[0010] Further, since the swallowing auxiliary drink of the present invention also has a function of enclosing various drugs, it is used for those who have a weak contraction of the muscles around the throat and those who have narrowed the esophagus due to muscle tension. Even so, the use of this swallowing auxiliary beverage reduces the uncomfortable feeling of the drug, and enables swallowing without throat.
Specifically, this wrapping function ensures that even a water-soluble powder is wrapped reliably and hardly elutes at room temperature, and the number of drugs that can be taken at one time in a solid preparation can be increased.

[0011] Furthermore, the masking of the medicine can be performed by the wrapping function. For example, since the present swallowing auxiliary drink also functions as a bitter mask, it is suitable for a child or the like to take the medicine.

[0012] Furthermore, despite having the above-mentioned wrapping function, most of the components of the present swallowing auxiliary drink are water, so that there is no effect on the disintegration and dissolution of the drug. And does not interfere with the efficacy of various drugs.

[0013] The swallowing aid drink is a low-calorie, non-sugar drink and does not affect the metabolism of insulin, so that it can be used safely even by diabetic patients. It is hard to become.

Furthermore, the present swallowing auxiliary drink is a simple drink containing water and a glue as essential components, and has excellent stability, so that it is easy to carry when filled in a small container or the like, and it is easy for patients to use. It is convenient when you go out.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the swallowing auxiliary drink of the present invention will be described in detail. As described above, the swallowing auxiliary beverage contains water and a paste. Here, as moisture,
Water suitable for drinking is sufficient, and examples thereof include tap water, various ion-exchanged waters, and purified water.

As the paste, it is sufficient that the paste is substantially uniformly mixed with water to impart viscosity or promote gelation, and specifically, agar, carrageenan, gellan gum, phaceleran, Gelatin, pectin, curdlan, locust bean gum, cod gum, guar gum,
Xanthan gum, alginic acid, alginates, Azotobacter vinelandi gum, cassia gum, silium seed gum, tamarind gum, CMCNa (carboxymethylcellulose Na), CMCCa, whey protein, starch or modified starch, and any mixtures thereof Can be.

The swallowing auxiliary beverage of the present invention comprises, as described above,
It is a mixture of water and paste, and its properties are a viscous liquid to a gel at room temperature. Specifically, in the case of a viscous liquid, the viscosity at 20 ° C. is 1000 to 25000 cP, In the case of jelly strength at 20 ° C. is 10 to 1
00 g / cm ² . When the jelly strength is less than 10 g / cm ² or the viscosity is less than 1000 cP, aspiration tends to occur in swallowing the medicine, while the jelly strength is 1 g / cm ^2.
If it exceeds 00 g / cm ² or if the viscosity exceeds 25000 cP, it becomes difficult for a person having difficulty in swallowing to swallow.

The content of the above-mentioned paste can be appropriately selected in consideration of the kind of the paste and the above-mentioned viscosity range. % By weight. On the other hand, the moisture is typically 8
The content may be 0.0 to 99.9% by weight.

In the swallowing aid beverage of the present invention,
As long as the effect of improving swallowing intended by the present invention is achieved, in addition to the essential components of water and paste, a gelling accelerator, a saccharide as a nutrient source, and other additives can be contained. For example, citric acid as a gelation accelerator is 0.2 to 2.0% by weight, trisodium citrate is 0.1 to 0.2% by weight,
Mannitol, erythritol, glucose and the like as saccharides can be added in an amount of 8 to 10% by weight. At this time, it is preferable that the saccharide can be drunk by a diabetic patient. Further, dextrin may be added as a gelling aid in an amount of 0.2 to 0.5% by weight.

Next, a method for preparing the swallowing auxiliary beverage of the present invention will be described. The swallowing auxiliary drink of the present invention is obtained by heating and dissolving an appropriate paste in an appropriate amount of water, and then adding a gelling accelerator, a gelling enhancer, saccharides and other additives and heating and stirring to dissolve. Obtainable. In addition, the melting temperature can be appropriately changed, but when heating and melting, typically 80 to
100 ° C.

Further, the swallowing auxiliary drink obtained as described above can be taken together with various drugs.
That is, after containing the drug in the mouth, the swallowing auxiliary drink may be poured into the mouth instead of water, and swallowed together with the drug,
The medicine and the swallowing auxiliary beverage may be mixed in advance, and the resulting mixture (liquid) may be poured into the mouth and swallowed.

As described above, the swallowing auxiliary drink of the present invention comprises:
Although it is intended for various drugs, it can be preferably applied particularly to drugs that have been conventionally difficult to swallow. As such a drug having difficulty in swallowing, tablets have a diameter of 10 mm.
The above and capsules can include the number one or more, but according to the present swallowing auxiliary drink, even if such tablets and capsules are used, the present swallowing having an appropriate viscosity or the like as described above. Since it is wrapped in the supplementary beverage, it can be easily swallowed.

In addition, granules and powders are likely to be caught between dentures, adhere to the mucous membrane in the mouth, and enter the trachea, making swallowing difficult. However, if the swallowing auxiliary drink of the present invention is used, Since the granules and the like are wrapped in the present swallowing auxiliary beverage to prevent adhesion in the mouth and the like, even such granules and powders can be easily swallowed. Also, after use, there is almost no residual feeling in the mouth like conventional soft drinks,
It is a refreshing aftertaste, and is a swallowing auxiliary beverage that can be preferably used especially for denture users.

Further, in the case of a drug having a strong odor or bitterness, the odor or bitterness is disliked and swallowing may be difficult. However, such a drug is wrapped and masked by the present swallowing auxiliary drink. It will be easy to swallow. Moreover, in this case, even in the case of a dosage form such as a powder, adhesion to the mouth and the like are prevented as described above, so that there is no problem that unpleasant odor or bitterness remains.

Furthermore, it has been conventionally known that swallowing becomes difficult when taking a mixed dose of a solid preparation and a powder. However, if the present swallowing auxiliary drink is used, it is easy to swallow even such a mixed dose. Will be able to do it.

[0026]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

(Example 1) Polysaccharides such as pectin, carrageenan, xanthan gum and agar as a paste are dissolved in a predetermined amount of water by heating, and other additives are added, and the mixture is heated and dissolved and stirred at 80 ° C. The gel was swallowed and dissolved to obtain a gelled swallowing auxiliary drink of this example. The details of the formulation are shown below.

Ingredients Amount (parts by weight) Agar 0.20 Locust bean gum 0.05 Pectin 0.04 Carrageenan 0.02 Xanthan gum 0.01 Citric acid 0.21 Trisodium citrate 0.14 Erythritol 8.82 Fragrance 0 .10 purified water 90.41 total amount 100.00 (parts by weight)

As shown in the above formulation, most of the obtained swallowing auxiliary drink is water, which does not affect the disintegration of the drug, and does not show any interaction with the drug. Furthermore, it has a clear taste with suppressed sweetness and is suitable for taking. About this swallowing assistance drink, a rheometer (manufactured by San Kagaku Co., Ltd., trade name: rheometer MODE
L COMPAC-100) was used to measure the jelly strength, and the results obtained are shown in FIG.

The jelly strength is determined by filling the swallowing auxiliary beverage into a sample collecting device placed on the elevator, and then raising the elevator to allow the filled swallowing auxiliary beverage to fill the cylindrical plunger arranged above. Is contacted, the ascent is further continued at a predetermined compression speed, the plunger is pierced, and the ascent is stopped at a certain clearance. Next, the lifting platform is lowered, and the resistance value (load) at this time is measured together with the downward displacement. From this load value, the following formula is used: jelly strength = maximum load (g) / plunger area (cm)
² ) Calculated according to

In this embodiment, a swallowing auxiliary drink is filled into a sampler having a bottom surface diameter of 40 mm to a height of 15 mm, the plunger diameter is 2 cm, and the compression speed is 10 mm /.
sec, the clearance was 5 mm, and the measurement temperature was 20 ° C. Than 1, the maximum load is 146 g, so the plunger area is 3.14 cm ^2, jelly strength of the swallowing assisting beverage of this example was 46.6 g / cm ^2.

Example 2 The same operation as in Example 1 was repeated, except that the following formulation was used, to obtain a swallowing auxiliary drink of this example. Jelly strength was measured in the same manner as in Example 1, and the obtained results are shown in FIG. In addition, the jelly strength of the swallowing auxiliary drink of this example was 51.9 g / cm ² .

Ingredients Amount (parts by weight) Agar 0.20 Locust bean gum 0.05 Pectin 0.04 Carrageenan 0.02 Xanthan gum 0.01 Citric acid 0.21 Trisodium citrate 0.14 Mannitol 8.81 Fragrance 0 .10 purified water 90.42 total amount 100.00 (parts by weight)

(Example 3) Guar gum and starch, which are polysaccharides, as a paste were dissolved in a predetermined amount of water together with other additives to obtain a viscous liquid swallowing auxiliary drink of this example.
The details of the formulation are shown below.

Ingredients Amount (parts by weight) Guar gum 1.00 Starch 1.00 Citric acid 0.21 Trisodium citrate 0.14 Erythritol 8.81 Fragrance 0.20 Purified water 88.64 Total amount 100.00 (Parts by weight) )

This swallowing auxiliary drink is supplied with a B-type rotational viscometer (manufactured by Shibaura System Co., Ltd., trade name: Bismetron VS-).
When the viscosity was measured using A), a value of 10,000 cP was shown. The viscosity was determined by setting the temperature of the swallowing auxiliary beverage to 20 ° C. The rotation was performed at 12 rpm using a 4-rotor, and the value was calculated by multiplying by a multiplier from the reading after 2 minutes.

Example 4 Xanthan gum and starch as pastes were dissolved together with other additives in a predetermined amount of water to obtain a viscous liquid swallowing auxiliary drink of this example.
The details of the formulation are shown below.

Ingredients Amount (parts by weight) Xanthan gum 0.50 Starch 1.50 Citric acid 0.21 Trisodium citrate 0.14 Erythritol 8.81 Fragrance 0.20 Purified water 88.64 Total amount 100.00 (Parts by weight) )

When the viscosity of this swallowing auxiliary drink was measured in the same manner as in Example 3, it showed a value of 8500 cP.

(Test Example 1) In order to investigate the wrapping function of the swallowing auxiliary beverage of the present invention, the swallowing auxiliary beverage of Example 1 was filled into a petri dish at room temperature, and an easily water-soluble granule was added thereto. Was observed. FIG. 3 shows the obtained results. In addition, light stirring was performed from the state shown in FIG. 3, and a change in the state was observed. The result is shown in FIG. FIG. 5 shows the state of FIG. 4 at different angles. Furthermore,
By changing the amount of the above swallowing auxiliary drink and easily water-soluble granules,
The same observation as above was performed, and the obtained results were shown in FIGS.
(After stirring).

(Test Example 2) [Comparative test with drinking water] Drinking water was filled in a petri dish instead of the swallowing auxiliary drink, and a readily water-soluble granule was added as in Test Example 1, and the state was observed. . FIG. 8 shows the obtained results.

From the results of Test Examples 1 and 2, it is clear that the swallowing auxiliary drink of Example 1 according to the present invention has an excellent wrapping function not found in drinking water. It is also clear that it is maintained even with a slight stirring. That is, in FIG. 3 and FIG. 6, the easily water-soluble granules do not dissolve and disperse but maintain almost the same shape.
Also in FIG. 7, the granules are hardly dissolved and are wrapped.

As described above, the swallowing auxiliary drink of the present invention can be appropriately wrapped even in the form of easily water-soluble granules and powders, so that these granules and the like do not adhere to the mouth when taken. Not only can they be prevented, but also granules and the like can be agglomerated, so that they can be easily taken.

In addition, the above-mentioned wrapping function is similar to an oblate, and can mask the bitterness of a drug.
Since bitterness etc. do not remain in the mouth, it is extremely suitable. When the swallowing auxiliary drink is heated to about body temperature (about 37 ° C.), its viscosity is reduced and the wrapping function is lost.
It does not prevent the drug from disintegrating and dissolving in the body.

(Test Example 3) The following tests were performed on the swallowing auxiliary drinks of Examples 1 and 2. That is, the target patients were a total of 32 females and 20 males aged 75 to 85 years old who had a decrease in swallowing ability, and the average age was 78 years. The evaluation was made in Examples 1 and 2.
The subject's opinion and nurse's findings were asked in the following five stages regarding the swallowing assisting effect when taking the medicine using the swallowing assistive drink. 1. Good 2. Good 3 I can't say either. Somewhat bad 5. bad

The internal medicines were 8 capsules, 16 tablets, 4 granules, and 4 powders. As a result, 3
All the opinions of the two patients and the nurse's findings were rated "good". The impressions of the patient and nurse at this time are shown below.

[Impressions of Patients and Nurses] Until now, tablets and powders were separately taken, but by using this swallowing auxiliary drink, they could be taken simultaneously at one time. . Even if the drug is mixed with this swallowing auxiliary drink, it will not melt and mush, it will feel like wrapped in an oblate,
It felt good in the mouth and was easy to take. When the herbal medicine powder was mixed with the present swallowing auxiliary drink and taken, the bitterness did not spread to the mouth and was easy to take. I was able to take the tablet without sipping it. Even when used by those who have no particular problem in swallowing, the use of swallowing a highly bitter drug significantly alleviated bitterness. When using herbal medicines and powders, it was easier to use this swallowing auxiliary drink than to wrap it in oblate and take it internally.

(Test Example 4) The following test was carried out on the swallowing auxiliary drink of Example 1 as follows. First, patients who have difficulty swallowing well with water when taking medicine (age 75, male)
The purpose of this test was explained and consent was obtained. Next, the capsule filled with barium powder in the No. 2 capsule was used as a simulated drug, and the simulated drug was taken by the patient using about 20 ml of the swallowing auxiliary beverage of the present invention, and the state of this dose was taken from the mouth to the stomach of the patient. , And the obtained image information was taken into a personal computer, and the change over time was analyzed as two still image data per second. The results obtained are shown in FIG.

Further, “Cup jelly 0” shown in FIG.
2, "Cup Jelly 03", "Cup Jelly 04",
Still images of “Cup jelly 09”, “Cup jelly 10” and “Cup jelly 12” are respectively shown in FIGS.
It is shown enlarged.

(Test Example 5) (Comparative test with water) Instead of swallowing auxiliary drink, about 20 m
The same operation as in Test Example 4 was repeated, except that 1 of water was used, and the obtained results are shown in FIGS. FIG.
6 to 18 shown in "water 00", "water 04", and "water 0".
Still images of “8”, “Water 11”, “Water 17”, and “Water 24” are enlarged and shown in FIGS. 19 to 24, respectively.

As is clear from the comparison between the results of Test Example 4 and the results of Test Example 5, in Test Example 4 which belongs to the scope of the present invention, the time required for the simulated drug to move from the mouth to the stomach is about This is 8 seconds, which is about 18 seconds in Test Example 5, which is twice or more times, which indicates that the swallowing assistant beverage of the present invention exhibits an excellent swallowing assisting effect.

[0052]

As described above, according to the present invention, a specific paste and water are mixed to adjust the viscosity or the jelly strength, so that swallowing with various drugs is improved, and It is possible to provide a swallowing auxiliary drink of a drug which is simple and can be replaced with ordinary drinking water, and which does not inhibit the drug effect.

In other words, if the drug is taken together with the swallowing aid beverage of the present invention, patients who have difficulty swallowing the drug or who have a reduced swallowing function, especially elderly people, can easily take the drug without feeling the foreign substance of the drug. You can then swallow. As described above, the swallowing auxiliary beverage of the present invention provides a quality of life (QOL) for a person who feels pain, albeit slightly, in taking a drug.
Life), and contributes to a comfortable life.

[Brief description of the drawings]

FIG. 1 is a characteristic diagram showing measurement results of a swallowing auxiliary beverage of Example 1 by a rheometer.

FIG. 2 is a characteristic diagram showing measurement results of a swallowing auxiliary beverage of Example 2 by a rheometer.

FIG. 3 is a photograph showing a state in which an easily water-soluble granule is added to a swallowing auxiliary beverage.

FIG. 4 is a photograph showing a state where slight stirring is added to the state of FIG. 3;

FIG. 5 is a photograph in which the angle of FIG. 4 is changed.

FIG. 6 is a photograph showing a state in which a readily water-soluble granule is added to a swallowing auxiliary beverage.

FIG. 7 is a photograph showing a state where slight stirring is added to the state of FIG. 6;

FIG. 8 is a photograph showing a state in which easily water-soluble granules are added to drinking water.

9 is still image data showing a state of taking in Test Example 4. FIG.

FIG. 10 is a partially enlarged view of FIG. 9;

FIG. 11 is a partially enlarged view of FIG. 9;

FIG. 12 is a partially enlarged view of FIG. 9;

FIG. 13 is a partially enlarged view of FIG. 9;

FIG. 14 is a partially enlarged view of FIG. 9;

FIG. 15 is a partially enlarged view of FIG. 9;

FIG. 16 is still image data showing a state of taking in Test Example 5.

17 is still image data showing a state of taking in Test Example 5. FIG.

18 is still image data showing a state of taking in Test Example 5. FIG.

19 is a partially enlarged view of FIG.

20 is a partially enlarged view of FIG.

FIG. 21 is a partially enlarged view of FIG. 16;

FIG. 22 is a partially enlarged view of FIG. 16;

FIG. 23 is a partially enlarged view of FIG. 17;

FIG. 24 is a partially enlarged view of FIG. 17;

Continued on the front page (72) Inventor Uejima Upper 5074 Nishiharuka, Ina-shi, Nagano Ina Food Industry Co., Ltd. (72) Inventor Mika Ota 5074 Nishiharuka-Nishi, Ina-shi, Nagano Ina Food Industry Co., Ltd. (56) Reference Document JP-A-5-139958 (JP, A) JP-A-8-26976 (JP, A) JP-A-6-7093 (JP, A) JP-A-7-274915 (JP, A) JP-A-7-27 236434 (JP, A) JP-A-6-141824 (JP, A) JP-A-10-234820 (JP, A) JP-B 64-6741 (JP, B1) (58) Fields investigated (Int. ⁷ , DB name) A61K 47/36 A23L 2/52 A61K 47/38 A61J 7/00

Claims (4)

(57) [Claims] 1. A low-calorie medicine for a person having difficulty swallowing which is taken together with a drug (however, excluding a seamless capsule containing a medicinal ingredient, a powder and a fine granule) to facilitate swallowing of the drug and does not inhibit the medicinal effect. A non-sugar swallowing auxiliary beverage, comprising 80.0 to 99.9% by weight of water, agar, carrageenan,
Gellan gum, furceleran, gelatin, pectin,
Curdlan, locust bean gum, tara gum, guar gum, xanthan gum, alginic acid, alginate,
Azotobacter vinelandi gum, cassia gum, silium seed gum, tamarind gum, CMCNa, CMC
0.1 to 5.0% by weight of at least one kind of paste selected from the group consisting of Ca, whey protein, starch and modified starch, is in the form of a viscous liquid, and has a viscosity of 1000 to 1000 at 20 ° C. 2
A swallowing auxiliary drink characterized by having a cP of 5000 cP. 2. A low-calorie medicine for a person having difficulty swallowing which is taken together with a drug (however, excluding a seamless capsule containing a medicinal ingredient, a powder and fine granules) to facilitate swallowing of the drug and does not inhibit the medicinal effect. A non-sugar swallowing auxiliary beverage, comprising 80.0 to 99.9% by weight of water, agar, carrageenan,
Gellan gum, furceleran, gelatin, pectin,
Curdlan, locust bean gum, tara gum, guar gum, xanthan gum, alginic acid, alginate,
Azotobacter vinelandi gum, cassia gum, silium seed gum, tamarind gum, CMCNa, CMC
0.1 to 5.0% by weight of at least one type of paste selected from the group consisting of Ca, whey protein, starch and modified starch, has a gel form, and has a jelly strength at 20 ° C of 10 to 10%. 10
A swallowing auxiliary drink characterized by having a weight of 0 g / cm ² . 3. The swallowing assistant drink according to claim 1, wherein the medicine is a tablet, a capsule, or a granule. 4. The swallowing auxiliary drink according to claim 1, wherein the medicine is a mixture of a solid preparation and a granule.