KR20100052934A - Oral composition for anticalculus - Google Patents

Abstract

PURPOSE: An oral composition for preventing dental calculus is provided to enhance sealing of calcium ion and to suppress dental calculus formation. CONSTITUTION: An oral composition contains metal ion sealing agent and glycinate surfactants an active ingredient. The hydrophilic part of the surfactant is sodium salt, potassium salt, or triethanol salt. The hydrophobic part is lauryl, myristyl, palmityl or cocoyl. The surfactant is sodium lauryl glycinate. The surfactant is contained in 0.1-10.0 weight% based on total weight. The metal ion sealing agent is pyrophosphate, and polyphosphate or polyphosphonate.

Description

Oral composition for preventing tartar formation {Oral composition for anticalculus}

The present invention relates to a composition for oral cavity effective in preventing tartar formation, and more particularly, it plays an important role in forming tartar by containing a glycinate-based surfactant together with a conventional metal ion sequestrant used as a tartar formation inhibitor. It relates to a composition for oral cavity which is very effective in increasing the blockage of calcium ions to prevent the formation of tartar.

In general, oral diseases are caused by various bacteria living in the oral cavity, and harmful oral bacteria eat and remnant such as food from the obtained film to proliferate to form plaques, and plaques are metal ions such as calcium and magnesium in saliva or blood. In combination with calcified calculus. Such plaque and tartar cause gum diseases such as gingivitis and periodontitis, and further damage the teeth. Regular brushing helps prevent the rapid formation of these deposits, but even regular brushing is not enough to remove all the stone deposits attached to the teeth. Therefore, to suppress plaque and tartar formation physically, abrasives are used, and chemically, antibacterial and metal ion blockers are used. Abrasives used in oral products include polymer materials such as calcium carbonate, silica, aluminum hydroxide, calcium phosphate, baking soda, polyethylene and polyvinyl chloride, and antibacterial agents used in oral products include cetylpyridinium chloride and hexahalonium chloride. , Benzalkonium chloride, decarinium chloride, chlorohexidine, triclosan, thymol, isopropylmethylphenol and alkyldiaminoethylglycolic acid, and metal ion sequestrants include pyrophosphate, polyphosphate and polyphosphate. Phosphates and the like.

As described above, metal ion sequestrants have been mainly used for suppressing tartar formation, but when metal ion sequestrants are used alone, there are some limitations on the removal of tartar. When an excessive amount of metal ion sequestrant is added to enhance the removal of tartar, irritation may occur, and the usability of taste may be deteriorated. In order to solve this problem, in addition to the existing metal ion blocker, a material that can have a synergistic effect on the removal of tartar is needed, and is trying to find it.

Accordingly, the present inventors have studied to find a composition for oral cavity which can effectively prevent the formation of tartar, and as a result, glycinate having the ability to chelate together with the metal ion sequestrant which has been used as an existing tartar formation inhibitor and suitable for oral use The present invention has been found to be effective in preventing the formation of tartar for oral compositions containing systemic surfactants.

Accordingly, it is an object of the present invention to provide an oral composition effective in preventing tartar formation by effectively increasing the blockage of calcium ions that play an important role in the formation of tartar by containing glycinate-based surfactant together with the metal ion sequestrant. .

In order to achieve the above object, the present invention provides a composition for oral cavity containing a metal ion sequestrant and glycinate-based surfactant as an active ingredient.

Oral composition according to the present invention by containing a glycinate-based surfactant together with the existing metal ion blocking agent has been used as a tartar formation inhibitor by further increasing the blockage of calcium ions that play an important role in the formation of tartar This prevents the formation more effectively and helps promote oral hygiene.

The present invention provides a composition for oral cavity containing a metal ion sequestrant and glycinate-based surfactant as an active ingredient.

Hereinafter, the present invention will be described in more detail.

The glycinate-based surfactants used in the composition of the present invention as foaming agents and chelating agents are amino acid-based surfactants and are hypoallergenic surfactants with low irritation to mucous membranes in the skin and oral cavity. Glycinate-based surfactants vary depending on the hydrophilic portion and the lipophilic portion. The hydrophilic portion may be used as sodium salt, potassium salt or triethanol salt, and the lipophilic portion may be lauryl, myristyl, palmityl or cocoyl. Given the foaming and feeling of use, the most preferred form is sodium lauryl glycinate.

The composition for oral cavity of this invention contains glycinate type surfactant at 0.1 to 10.0 weight% with respect to the total weight of a composition, More preferably, it is 0.5 to 2.0 weight%. If the content is less than 0.1% by weight, the foaming power is weak and the feeling is not good, and if the content exceeds 10.0% by weight, it is not preferable because it may irritate the oral mucosa.

Metal ion sequestrants in the compositions of the present invention can be used as a plaque formation inhibitor, pyrophosphate, polyphosphate, polyphosphonate and mixtures thereof, preferably pyrophosphate. Pyrophosphates useful in the compositions of the present invention include dialkali metal pyrophosphates, tetraalkali metal pyrophosphates and mixtures thereof. Specific examples are the anhydrous and hydrated forms of disodium dihydrogen pyrophosphate, tetrasodium pyrophosphate and tetrapotassium pyrophosphate.

The composition for oral cavity of the present invention contains a metal ion blocking agent in an amount of 0.1 to 10.0% by weight, more preferably 1.0 to 5.0% by weight based on the total weight of the composition. If the content is less than 0.1% by weight, the ability to inhibit tartar formation is weak, and when the content exceeds 10.0% by weight, it is not preferable because the feeling of taste, such as when brushing, may be poor and irritation may occur.

The composition for oral cavity of this invention is not specifically limited in the formulation, For example, it may have formulations, such as a toothpaste, a mouthwash, and a tooth whitening agent.

The composition for oral cavity of the present invention may contain abrasives, wetting agents, auxiliary foaming agents, binders, sweeteners, pH adjusting agents, preservatives, active ingredients, fragrances, brighteners, pigments, solvents and the like which are commonly used according to the formulation and purpose of use. .

The abrasives include calcium carbonate, precipitated silica, aluminum hydroxide, calcium dihydrogen phosphate, insoluble sodium metaphosphate, etc., and these abrasives are used singly or in combination of two or more thereof to use 1 to 30% by weight based on the total weight of the composition.

Examples of the humectant include glycerin, sorbitol solution, polyethylene glycol, propylene glycol, and the like, or 10 to 30% by weight of two or more kinds thereof are used.

In addition to the glycinate-based surfactant, as an auxiliary surfactant, anionic surfactants and betaines such as sulfate-based, sulfosuccinate-based, sacosinate-based, phosphate-based, isethionate-based, glutamate-based, and taurate-based, Amphoteric surfactants such as sultaine and ampoacetate, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene (cured) castor oil, glycerin fatty acid esters, sorbitan fatty acid esters, sucrose fatty acid esters, alkylolamides, alkylglucose Nonionic surfactants, such as a seed and cationic surfactants, such as N-alkyldiamino ethylglycine, are used individually or in mixture of 2 or more types, and 0.5 to 10 weight%, Preferably 0.5 to 2.0 weight% is used.

As the binder, hydroxyethyl cellulose, hydroxypropyl cellulose, xanthan gum, carrageenan, sodium alginate, or the like may be used alone or in combination of two or more, and 0.1 to 5% by weight, preferably 0.1 to 2% by weight.

As the sweetener, saccharin sodium, aspartame, stevioside, xylitol, licorice acid, etc. may be used alone or in combination of two or more, and 0.05 to 5% by weight is used.

The pH adjusting agent includes sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, sodium citrate, citric acid, tartaric acid, and the like, and preservatives such as methyl paraoxybenzoate, propyl paraoxybenzoate, and sodium benzoate alone or two kinds. Mix and use the above.

Examples of the active ingredient include sodium fluoride, sodium monofluorophosphate, tin fluoride, chlorohexidine, allantoin chlorohydroxy aluminate, aminocaproic acid, triclosan, cetylpyridium chloride, zinc chloride, pyridoxine hydrochloride, tocopherol acetate, and the like. Or a mixture of two or more thereof, and a suitable amount of peppermint oil, spearmint oil, menthol, and anetol as a flavoring agent, mixed with titanium oxide as a brightener, food coloring as a pigment, It is manufactured according to a conventional toothpaste manufacturing method with a solvent.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the scope of the present invention is not limited thereto.

[Test Example 1] Comparison of chelate generation ability according to the type of surfactant

After dissolving 2.7 mmol of calcium chloride (CaCl ₂ ) in 200 ml of water and stirring evenly by adding 3 mmol of each surfactant, the mixture was left to stand for 24 hours, and then the chelating ability was evaluated according to the amount of precipitated material. Table 1 shows. (Evaluation Criteria X: not formed / ○: formed a little / ⊙: formed a lot)

division Type of surfactant Precipitation Negative ion
Surfactants Sulfate Sodium Lauryl Sulfate X Carboxylate Potassium lauryl carboxylate ⊙ Phosphate Potassium lauryl phosphate ⊙ Sulfosuccinate Sodium Lauryl Sulfosuccinate ⊙ Glutamate Sodium Lauryl Glutamate ○ Isethionate system Sodium cocoyl isethionate ○ Taurate Sodium cocoyl taurate ○ Glycinate Sodium Lauryl Glycinate ⊙ Sacosinate Sodium Lauryl Sacosinate ⊙ Amphoteric
Surfactants Betaine Cocamido Profile Betaine X Sultine Kokamido Profile Sultine X Ampoacetate Sodium Lauro Ampoacetate ○

As can be seen in Table 1, in the anionic surfactant, carboxylate-based, phosphate-based, sulfosuccinate-based, glycinate-based, and sacosinate-based precipitates were formed. In addition, among the glutamate-based, isethionate-based, taurate-based, and amphoteric surfactants, the ampoacetate-based precipitates slightly formed, and the other surfactants did not form precipitates at all. In Test Example 2 below, a representative toothpaste composition of the composition for oral cavity was prepared using surfactants having a large amount of precipitation, and compared with the feeling of use.

Test Example 2 Comparison of Feeling of Toothpaste Composition

Toothpaste compositions (Example 1 and Comparative Examples 1-6) were prepared in the compositions shown in Table 2 below. Example 1 is a toothpaste composition containing the glycinate-based surfactant of the present invention. Comparative Examples 1 to 4 include other anionic surfactants having high chelate generating ability, and Comparative Example 5 is a dentifrice composition containing a sulfate-based surfactant which is commonly used but has a poor chelate generating ability. Comparative Example 6 is a dentifrice composition containing no surfactant as a foaming agent and a chelating agent.

division Ingredient Name Example 1
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Comparative Example 3
(weight%) Comparative Example 4
(weight%) Comparative Example 5
(weight%) Comparative Example 6
(weight%) solvent Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 Tartar Formation Inhibitor Tetrasodium Pyrophosphate 3.4 3.4 3.4 3.4 3.4 3.4 3.4 Active ingredient Sodium monofluorophosphate 0.6 0.76 0.76 0.76 0.76 0.76 0.76 Wetting agent Sorbitol liquid (70%) 25 25 25 25 25 25 25 Sweetener Zaccarin Sodium 0.3 0.3 0.3 0.3 0.3 0.3 0.3 pH regulator Sodium citrate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 abrasive Silica 20 20 20 20 20 20 20 Thickener Carboxymethyl Cellulose Sodium 2.0 2.0 2.0 2.0 2.0 2.0 2.0 antiseptic Methyl paraben 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Spices Combination spices 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Brightener Titanium dioxide 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Foam
or
Chelating agents Sodium Lauryl Glycinate 2 - - - - - Potassium lauryl phosphate - 2 - - - - - Sodium Lauryl Sulfosuccinate - - 2 - - - - Potassium lauryl carboxylate - - - 2 - - - Sodium Lauryl Sacosinate - - - - 2 - - Sodium Lauryl Sulfate - - - - - 2 -

Optionally, the use groups of Example 1 and Comparative Examples 1 to 6 were divided by 20, respectively. Example 1 and Comparative Examples 1 to 6 were each provided to the subjects to be brushed in a habitual manner, and two weeks later, the flavor and usability were evaluated through a questionnaire on a 5-point scale. The results are shown in Table 3 below. (1 point: very dissatisfied / 2 points: unsatisfied / 3 points: moderate / 4 points: satisfied / 5 points: very satisfied)

division Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Flavor 4.0 1.0 2.0 1.0 2.0 4.0 4.0 Bubble 3.8 2.5 2.5 4.0 3.0 4.0 1.0 Irritation 3.5 3.5 3.5 2.0 2.0 3.5 4.0 Overall satisfaction 4.0 1.0 2.0 1.0 2.0 4.1 1.0

As can be seen in Table 3, the toothpaste composition (Example 1) according to the present invention has a flavor, foaming power, irritation and overall satisfaction compared to Comparative Examples 1 to 4 containing other surfactants that were relatively excellent in chelating ability All this was high. Comparative Examples 1 to 4 obtained a very low score in terms of flavor because of the strong bitter taste, the foaming is also poor, the overall satisfaction was very low. In addition, Example 1 using sodium lauryl glycinate as a glycinate-based surfactant showed similar satisfaction as Comparative Example 5 including sodium lauryl sulfate, which is generally used, and does not contain a surfactant as a foaming agent. The foaming force and overall satisfaction were higher than the comparative example 6.

Test Example 3 Measurement of Removal Ability for Calcium Ions (in-vitro)

After dissolving 2.7 mmol of calcium chloride (CaCl ₂ ) in 200 ml of water, 1 mmol of tetrasodium pyrophosphate and sodium cocoyl glycinate were added thereto, and the mixture was stirred evenly and left for 24 hours. After precipitation, the precipitate was filtered using filter paper, and the residual calcium ion concentration was measured quantitatively by ion chromatography. The results are shown in Table 4 below.

division Tetrasodium pyrophosphate (1 mmol) Tetrasodium Pyrophosphate (1 mmol) +
Sodium cocoyl glycinate (1 mmol) Calcium ion concentration supplied from calcium chloride 1,500.00 ppm 1,500.00 ppm Remaining calcium ion concentration 416.14 ppm 258.34 ppm

As can be seen in Table 4, when only tetrasodium pyrophosphate was used as the metal ion sequestrant, the removal degree for calcium ions was 72.25%, and tetrasodium pyrophosphate was used as the metal ion sequestrant, and the chelating surfactant was used. When used together with sodium sodium cocoylglycinate, the degree of removal for calcium ions was 82.77%. Therefore, it was found that the removal of calcium ions, which play an important role in the formation of calculus, is increased by about 10% when the metal ion sequestrant and the chelating surfactant glycinate-based surfactant are used together.

Test Example 4 Measurement of Tartar Formation Inhibitory Effect (Tortar Index)

After confirming the initial oral condition of the 80 test subjects, the entire tooth of the test subject was cleaned with the ultrasonic tartar remover, and the toothpaste prepared as shown in Table 2 was used as 40 in each of the use groups of Example 1 and Comparative Example 6. After giving in portions, brushing was done in a customary manner and the calculus index was checked after 4 and 8 weeks.

The modified Volpe-Manhold calculus index method was used as a method for the calculus index test. The improved Volpe-Manhold method is a method of measuring and summing up the maximum width of calculus attached to the tongue of mandibular six anterior teeth from 33 to 43 for each tooth. At this time, the area measured by each tooth is the three parts of the central part of the tongue, the diagonal centrifugal part passing through the mesial right angle, and the diagonal mesial part passing through the centrifugal right angle, and each of these areas is 0, 0.5, 1 using a periodontal probe. , Rated and summed to 2, and 3 mm. The results are shown in Table 5 below.

Experiment period Example 1 Comparative Example 6 Statistical significance 4 weeks 0.72 ± 0.15 0.75 ± 0.17 P> 0.05 8 Weeks 1.15 ± 0.25 1.22 ± 0.15 P <0.05

As can be seen in Table 5, Example 1 using the tetrasodium pyrophosphate and sodium lauryl glycinate of the present invention after 4 weeks compared to Comparative Example 6 using only tetrasodium pyrophosphate as a metal ion blocking agent The calculus index decreased by about 4%. In addition, after 8 weeks, Example 1 showed a decrease in calculus index of about 6% compared to Comparative Example 6. Therefore, it was found that the composition for oral cavity containing both the metal ion blocking agent and the glycinate-based surfactant of the present invention is more effective in preventing tartar formation.

Claims (7)

An oral composition comprising a metal ion sequestrant and a glycinate surfactant as an active ingredient. The composition for oral cavity according to claim 1, wherein the hydrophilic portion of the glycinate-based surfactant is sodium salt, potassium salt or triethanol salt, and the lipophilic portion is lauryl, myristyl, palmityl or cocoyl. The composition for oral cavity of claim 1, wherein the glycinate-based surfactant is sodium lauryl glycinate. The composition for oral cavity of claim 1, wherein the glycinate-based surfactant is contained in an amount of 0.1 to 10.0 wt% based on the total weight of the composition. The oral composition according to claim 1, wherein the metal ion blocking agent is at least one selected from the group consisting of pyrophosphate, polyphosphate and polyphosphonate. The composition for oral cavity of claim 1, wherein the metal ion sequestrant contains 0.1 to 10.0 wt% based on the total weight of the composition. The composition for oral cavity according to any one of claims 1 to 6, wherein the composition prevents tartar formation.