KR20100042090A - Composition for whitening containing extract of jasminum grandiflorum - Google Patents
Composition for whitening containing extract of jasminum grandiflorumInfo
- Publication number
- KR20100042090A KR20100042090A KR1020080101227A KR20080101227A KR20100042090A KR 20100042090 A KR20100042090 A KR 20100042090A KR 1020080101227 A KR1020080101227 A KR 1020080101227A KR 20080101227 A KR20080101227 A KR 20080101227A KR 20100042090 A KR20100042090 A KR 20100042090A
- Authority
- KR
- South Korea
- Prior art keywords
- extract
- composition
- whitening
- skin
- jasmine
- Prior art date
Links
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- 239000000203 mixture Substances 0.000 title claims abstract description 52
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- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 4
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- 238000000034 method Methods 0.000 claims description 11
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
Abstract
Description
본 발명은 자스민 추출물을 유효성분으로 함유하는 미백용 조성물에 관한 것으로, 보다 구체적으로는 자스민 추출물과 피부학적으로 허용된 담체를 함유한 화장용 조성물 및 자스민 추출물과 식품학적으로 허용된 담체를 함유한 식품 조성물에 관한 것이다.The present invention relates to a whitening composition containing jasmine extract as an active ingredient, and more particularly, to a cosmetic composition containing jasmine extract and a dermatologically acceptable carrier, and a jasmine extract and a food acceptable carrier. It relates to a food composition.
피부는 외부 환경과 직접 접하면서 인체를 보호하며 생화학적이고 물리적인 기능을 가지고 있는 아주 중요한 조직으로, 크게 3가지 즉, 표피(epidermis), 진피(dermis), 그리고, 피하(hypodermis)로 나누어진다. 멜라닌은 피부의 표피층에 존재하는 색소로서, 표피의 기저층에 존재하는 멜라노사이트(melanocyte)로부터 만들어져 케라티노사이트(keratinocyte)라는 표피 세포로 이동하게 된다. 생체 내에는 멜라닌을 분해하는 효소가 없고, 다만 케라티노사이트가 표피에서 떨어져나갈 때 같이 피부에서 떨어져나가는 것으로 제거된다.Skin is a very important tissue that protects the human body while directly contacting the external environment and has biochemical and physical functions. The skin is divided into three types: the epidermis, the dermis, and the hypodermis. Melanin is a pigment present in the epidermal layer of the skin. It is made from melanocytes in the basal layer of the epidermis and migrates to epidermal cells called keratinocytes. There are no enzymes in the body that break down melanin, but they are removed by falling off the skin as keratinocytes fall off the epidermis.
멜라닌 합성 과정을 살펴보면, 멜라노사이트 내의 멜라노좀이라는 소포체에서 먼저 티로시나제(Tyrosinase)라는 효소에 의해 티로신이 도파 (DOPA)를 거쳐 도파퀴논 (DOPAquinone)으로 전환되고, 도파퀴논으로부터 자동 산화 반응과 효소 반응으로 도파크롬 (DOPAchrome)을 거쳐 흑갈색의 공중합체인 멜라닌이 생성된다. 이렇게 생성된 멜라닌은 멜라노좀을 통해 케라티노사이트로 옮겨지고 여기에서 약 28일간의 각화 과정을 거치면서 피부 표면으로 나와 각질과 함께 소실된다.In the melanin synthesis process, melanocyte vesicles in melanocytes are first converted into tyrosine through dopa (DOPA) by an enzyme called tyrosinase and then into dopaquinone (DOPAquinone). Dopachrome produces melanin, a blackish brown copolymer. The melanin thus produced is transferred to keratinocytes through the melanosomes, where it is lost to the surface of the skin along with the keratinization process for about 28 days.
멜라닌은 햇빛 UV의 빛 에너지를 흡수하여 UV에 의한 손상으로부터 진피 이하의 피부 기관을 보호하는 역할을 하며, 피부 생체 내에 생겨난 유해산소 및 프리라디칼 등을 잡아주는 등 외부 유해인자로부터 피부를 보호해주는 유용한 역할을 수행한다. 또한, 피부 세포 내의 멜라닌 양에 따라 사람의 피부색을 결정하게 되며 멜라닌 색소가 많은 사람은 갈색 또는 검은 색 피부를 갖는 반면, 멜라닌 색소가 적은 사람은 흰색의 피부를 갖게 된다.Melanin absorbs the light energy of sunlight UV to protect skin organs under the dermis from UV damage, and it protects the skin from external harmful factors such as trapping harmful oxygen and free radicals generated in skin skin. Play a role. In addition, the skin color of a person is determined according to the amount of melanin in the skin cells, and those with a lot of melanin pigment have brown or black skin, while those with a small amount of melanin have white skin.
멜라닌이 비정상적으로 적게 생산되면 백반증과 같은 피부병변이 유발되고, 이와 반대로 일광, 호르몬변화, 염증, 약제 등에 의한 멜라닌이 과도하게 합성되거나 각화작용이 원활히 이루어지지 않아 멜라닌이 축적되는 경우 피부에 손상을 줄 뿐 만 아니라 피부의 색소가 침착되어 기미, 주근깨를 형성하며, 이와 같은 병변으로부터 나아가 피부암의 원인이 되기도 한다. 따라서, 이러한 색소 침착 현상을 방지하기 위해서는 멜라닌 생성 과정의 일부분을 저해하여 멜라닌의 생성을 감소시켜야 한다.When abnormally low melanin is produced, skin lesions such as vitiligo are caused, and conversely, if melanin accumulates due to excessive synthesis or keratinization due to excessive daylight, hormonal changes, inflammation, and drugs, damage to the skin can occur. In addition to the skin pigments are deposited to form blemishes, freckles, and even from these lesions can cause skin cancer. Therefore, in order to prevent such pigmentation phenomenon, it is necessary to inhibit a part of melanogenesis process to reduce melanin production.
오늘날 동양권의 여성들은 하얗고 깨끗한 피부를 선호하며 이를 미의 중요한 기준으로 삼고 있기 때문에 피부색소 이상침착의 치료 및 미용욕구 충족을 위한 미백제에 대한 개발이 활발히 이루어지고 있다. 현재 피부미용을 위한 미백제의 개발에 있어서, 생성된 멜라닌 색소를 환원시켜 탈색하는 방법과 멜라닌 색소를 형성하는 효소인 티로시나제의 활성을 억제하는 방법이 알려져 있다. 그러나 멜라닌 색소를 환원시키기 위해 사용되는 토코페롤이나 비타민류 등을 사용한 미백제는 멜라닌 색소의 탈색효과가 미미한 것으로 알려져 있으며, 따라서 멜라닌 색소의 생성을 억제하는 저해제에 관한 연구가 다수 진행되고 있다.Today, Asian women prefer white and clean skin and make it an important standard of beauty. Therefore, the development of whitening agent for treatment of abnormal skin pigmentation and satisfying beauty needs is being actively developed. At present, in the development of a whitening agent for skin beauty, a method of reducing the generated melanin pigment by decolorization and a method of inhibiting the activity of tyrosinase, an enzyme that forms melanin pigment, are known. However, whitening agents using tocopherols and vitamins used to reduce the melanin pigment are known to have a slight decolorizing effect of the melanin pigment. Therefore, many studies have been conducted on inhibitors that inhibit the production of melanin pigment.
종래의 화장품 분야에서는 미백성분으로서, 예를 들면, 코지산(Kojic acid), 알부틴(Arbutin) 등과 같은 티로시나제 효소활성을 억제하는 물질, 하이드로퀴논(Hydroquinone), 비타민-C(L-Ascorbic acid) 및 이들의 유도체와 각종 식물 추출물이 사용되어 왔다.In the conventional cosmetic field, as a whitening component, for example, substances that inhibit tyrosinase enzyme activity such as kojic acid, arbutin, hydroquinone, vitamin-C (L-Ascorbic acid) and Their derivatives and various plant extracts have been used.
그러나, 상기 미백성분들은 처방계 중에서 안정성이 나빠 분해되어 착색되거나, 이취의 발생, 생체 레벨에서의 효능, 효과의 불분명 및 안전성 문제 등으로 그 사용이 제한되고 있는 실정이다. 코지산은 티로시나제의 활성부위에 존재하는 구리이온을 흡착시켜 효소활성을 저해하지만, 화장품에 배합 시 불안정성, 피부 부작용의 문제 및 최근 동물실험 결과 간암유발이 밝혀져 화장품 원료로 사용이 중지되었다. 비타민-C 및 그 유도체는 산화가 잘되는 불안정성 때문에 화장품 원료로서 사용이 어려우며, 하이드로퀴논은 피부에 대한 미백효과는 탁월하지만 알레르기를 유 발하는 성질, 멜라닌 생성 세포에 대한 독성, 피부에의 영구 탈색화 등 피부에 대한 자극성이 높으며, 최근 발암성 물질로 규정되어 사용이 금지되어 각 나라별로 제한적인 농도만 허가하고 있다. 또한, 알부틴은 하이드로퀴논에 글루코피라노사이드(Glucopyranoside)가 결합된 유도체로 하이드로퀴논 사용 시 나타나는 부작용이 적으면서 인체에 대한 독성은 없이 멜라닌 색소의 합성을 억제하는 작용이 있어, 멜라닌 색소 침착이 증가되는 피부질환의 치료제로서 이용가능성이 제시되었으나, 피부효소에 의해 일부 분해되는 단점이 있다.However, the whitening components are deteriorated due to poor stability in the prescription system, or the use thereof is limited due to the occurrence of off-flavor, efficacy at the biological level, unclear effect and safety problems. Kojic acid inhibits enzymatic activity by adsorbing copper ions present in the active site of tyrosinase, but has been discontinued as a raw material for cosmetics because of its instability, skin side effects and recent animal experiments. Vitamin-C and its derivatives are difficult to use as raw materials for cosmetics due to their oxidative instability. Hydroquinone has excellent whitening effect on skin, but it causes allergies, toxicity to melanin producing cells, permanent depigmentation to skin, etc. It is highly irritating to skin, and is recently prescribed as a carcinogenic substance, so its use is banned and only a limited concentration is allowed in each country. In addition, arbutin is a derivative in which glucopyranoside is combined with hydroquinone, and has little side effects when using hydroquinone and inhibits the synthesis of melanin pigments without toxicity to humans, thereby increasing melanin pigmentation. Applicability has been suggested as a therapeutic agent for skin diseases, but it has a disadvantage of being partially degraded by skin enzymes.
이들 미백물질들 외에 천연물 특히 식물 중에서 미백활성성분을 찾기 위한 연구도 계속 이루어져왔고, 그 중 상백피(일본공개특허 소 55-44375호, 소 64-26507호, 소 64-83009호, 평 1-25687호, 평 5-139950호 및 대한민국 공개특허 제92-002109호, 제97-021273호), 감초(일본공개특허 소 60-214721호, 소 60-214728호, 소 63-23809호, 소 64-63506호, 평 1-149706호 및 대한민국 공개특허 제92-002109호, 제97-025601호), 작약(일본공개특허 소 61-246109호 및 대한민국 공개특허 제92-002111호), 계피(일본공개특허 소 63-30403호, 평 5-139954호), 고삼(일본공개특허 소 64-26507호 및 대한민국 공개특허 제92-002110호), 갈근(일본공개특허 소 60-214727호, 소 64-16709호), 당귀(일본공개특허 소 56-92211호, 평 4-26610호), 목단피(일본공개특허 소 60-214721호, 소 61-50915호, 소 61-246109호), 반하(일본공개특허 평 2-207028호, 대한민국 공개특허 제96-033442호), 알로에(일본공개특허 소52-44375호, 평 2-207030호, 평 5-139950호)등 다수의 식물추출물 및 생약재 추출물 등이 티로시나제에 작용하여 멜라닌 생성을 억제한다는 사실이 밝혀 졌으나, 이들 역시 안전성, 변색 가능성 등의 측면에서 화장품이나 의약품에 유효농도 이상으로 사용하는 데는 많은 문제점을 갖고 있으며, 아직 뛰어난 효과를 나타내지도 못하고 있는 실정이다.In addition to these whitening substances, research has been conducted to find whitening active ingredients in natural products, especially plants. Among them, white skin (Japanese Patent Application Laid-Open No. 55-44375, Small 64-26507, Small 64-83009, Pyeong 1-25687 No. 5-139950, Korean Patent Publication Nos. 92-002109, 97-021273, Licorice (Japanese Patent Laid-Open No. 60-214721, No. 60-214728, No. 63-23809, No. 64- 63506, Hei 1-149706, and Korean Patent Nos. 92-002109, 97-025601), Peony (Japanese Patent Laid-Open No. 61-246109 and Korean Laid-Open Patent No. 92-002111), Cinnamon Patent Nos. 63-30403, Hep. 5-139954), Gosam (Japanese Patent Laid-Open No. 64-26507 and Korean Patent Laid-Open No. 92-002110), Brown root (Japanese Laid-Open Patent Nos. 60-214727, Small 64-16709 ), Angelica (Japanese Patent Laid-Open No. 56-92211, Hei 4-26610), Mokdanpi (Japanese Laid-Open Patent No. 60-214721, No. 61-50915, No. 61-246109), Banha (Japanese Laid-Open Patent Publication) Pyeong 2-207028, Korea A number of plant extracts and herbal extracts, such as Japanese Patent Application Laid-Open No. 96-033442) and Aloe (Japanese Patent Laid-Open No. 52-44375, Hei 2-207030, Hei 5-139950), act on tyrosinase to inhibit melanin production. Although it has been found that, they also have a lot of problems in the use of more than the effective concentration in cosmetics or pharmaceuticals in terms of safety, discoloration, etc., and still does not show an excellent effect.
이에 본 발명자들은 멜라닌 생성을 억제하면서도 안정성이 뛰어나고, 변색가능성이 적은 미백용 조성물을 개발하고자 예의 연구 노력한 결과, 중국 티벳 지역의 고산지대에서 자생하는 식물인 자스민(Jasminum grandiflorum) 추출물이 멜라닌 생성을 감소시키고, 안정적으로 피부에 작용하여 미백용 조성물로 유용하게 사용될 수 있음을 확인하고 본 발명을 완성하였다.Accordingly, the present inventors have diligently researched to develop a whitening composition which is excellent in stability and less discoloration while suppressing melanin production. As a result, Jasminum grandiflorum extract, which is a plant native to the high mountains of Tibet, China, reduces melanin production. And it was confirmed that can be usefully used as a composition for whitening to act on the skin stably and completed the present invention.
따라서, 본 발명의 목적은 자스민 추출물을 유효성분으로 함유하는 미백용 조성물을 제공하는 것이다.Accordingly, it is an object of the present invention to provide a whitening composition containing jasmine extract as an active ingredient.
본 발명의 또 다른 목적은 자스민 추출물과 피부학적으로 허용된 담체를 함유한 화장용 조성물 및 자스민 추출물과 식품학적으로 허용된 담체를 함유한 식품 조성물을 제공하는 것이다.It is still another object of the present invention to provide a cosmetic composition containing jasmine extract and a dermatologically acceptable carrier and a food composition containing jasmine extract and a foodologically acceptable carrier.
본 발명은 한 관점으로서, 자스민 추출물을 유효성분으로 함유하는 미백용 조성물을 제공한다.In one aspect, the present invention provides a composition for whitening containing jasmine extract as an active ingredient.
본 발명의 자스민(Jasminum grandiflorum)는 쌍떡잎식물 용담목 물푸레나무과 영춘화속에 속하는 식물을 총칭하며, 이 속(屬)의 꽃에서 채취한 향료명을 가리키기도 한다. 상록관목이며, 열대와 아열대에 200여 종이 분포하고 한국에 자생종은 없으나 영춘화(迎春花:J. nudiflorum)가 서울 근처에서 월동한다. 소형화(素馨花:J. officinale var. grandiflorum)는 히말라야 원산이며 흰색 꽃이 피고 향료를 채취한다. 청향등(淸香藤:J. paniculatum)으로 재스민차를 만든다. Jasminum ( Jasminum grandiflorum ) of the present invention is a generic name for plants belonging to the genus Asteraceae genus Asteraceae, and also refers to the fragrance name collected from the flowers of the genus (屬). It is an evergreen shrub, with more than 200 species distributed in the tropics and subtropics. There are no native species in Korea, but Young Chunhwa (J. nudiflorum) overwinters near Seoul. Miniaturized (J. officinale var. Grandiflorum) is native to the Himalayas, white flowers bloom and spices are collected. Jasmine tea is made with Cheonghyang-Dung (淸 香 藤: J. Paniculatum).
꽃은 방향성이 강해 향료를 채취하기 위하여 재배하고, 뿌리가 잘 내리므로 꺾꽂이와 휘묻이로 번식시킨다.Flowers are highly directional and are cultivated for harvesting fragrances. They are well rooted and multiply by pickles and burrows.
효능은 생리의 고통을 줄여 기분을 좋게 해주는데 도움을 주며, 피부미용, 우울할 때 기분 전환에 도움을 준다. 또한, 분만촉진, 소독, 자궁강장, 진경, 진정, 최유, 최음, 통경, 피부연화, 항우울작용을 하며, 중증의 우울증에 대하여 우수한 약제이며, 신경을 진정시킴과 동시에 정서에도 가온성이 있어서 적극적인 자신감을 생기게 하고, 에너지를 불러일으키며 전반적으로 원기회복을 시켜준다.Efficacy helps to reduce the pain of menstruation and improve mood. It also helps to change the skin when you are beauty or depressed. In addition, it promotes delivery, disinfection, uterine tonic, jingyeong, soothing, supremacy, aphrodisiac, pain relief, skin softening, antidepressant effect, and is an excellent drug for severe depression, soothing nerves and warming emotions It creates active self-confidence, inspires energy and rejuvenates overall.
자궁수축을 강화시켜 분만을 촉진하고 동시에 고통을 덜어주며. 호르몬의 평형을 주는 힘이 뛰어나기 때문에 산후의 우울증에도 유효하다고 알려져 있다. 모유의 흐름을 촉진시키고, 자궁의 경련과 월경통을 완화시키며, 질의 감염증 전반에도 효과적이다. 남성의 생식기에도 자스민은 중요한 역할을 하는데 정자의 수를 증가시키므로써 불임증을 개선시킬 수 있으며, 강력한 완화특성이 있어서 임포텐츠와 조루증 그리고 여성의 냉감증과 같은 성적장애에 뛰어난 효과가 있다. 이 정유는 호흡기 계통에도 유익하여 기관지의 경련을 완화시켜줌과 동시에 인후를 아프게 하는 기침을 진정시키는 작용을 하며 쉰 목소리를 호전시키고 수족의 경직을 완화시키기도 한다.Strengthens uterine contractions, promotes labor and relieves pain at the same time It is known to be effective in postpartum depression because of its excellent balance of hormones. It promotes the flow of breast milk, relieves cramps and dysmenorrhea in the uterus, and is also effective in vaginal infections. Jasmine also plays an important role in the genitals of men, which can improve infertility by increasing the number of sperm, and its powerful palliative properties have excellent effects on sexual disorders such as impotence, premature ejaculation, and cold sores in women. The essential oils are also beneficial to the respiratory system, relieving bronchial spasms, soothe coughs, and sore throats, improving hoarseness and reducing stiffness in the limbs.
자스민 오일은 건조해서 손상된 피부나 민감성 피부의 진정, 회복에 효과적, 피부의 탄력을 주어 기미와 임신선, 방지와 회복에 효과적이다.Jasmine oil is effective in calming and restoring damaged or sensitive skin, giving it elasticity, preventing blemishes, pregnancy lines, and preventing and recovering.
본 발명에 따른 자스민 추출물은 바람직하게는, 물, 탄소수 1 내지 4의 저급 알코올 또는 이들의 혼합 용매로부터 선택된 극성 용매를, 가장 바람직하게는 메탄올을 첨가하여 열수 추출하여 제조할 수 있다.Jasmine extract according to the present invention is preferably, a polar solvent selected from water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, most preferably can be prepared by hot water extraction by adding methanol.
상기 추출물의 미백 효과는 멜라닌 생성의 저해함으로써 이루어지는 것을 특징으로 한다.The whitening effect of the extract is characterized in that it is made by inhibiting melanin production.
본 발명에 의한 자스민 추출물의 제조과정을 살펴보면 다음과 같다.Looking at the manufacturing process of the jasmine extract according to the present invention.
자스민을 물로 깨끗이 세척한 후, 그늘에서 건조한다. 건조한 자스민을 추출용기에 넣고, 적당량의 추출 용매에 적절한 온도에서 일정 시간 추출한다. 추출물은 여과되고, 진공회전증발기 등을 이용하여 농축될 수 있다.Jasmine is washed thoroughly with water and dried in the shade. Dry jasmine is placed in an extraction container, and extracted with a suitable amount of extraction solvent at a suitable temperature for a predetermined time. The extract can be filtered and concentrated using a vacuum rotary evaporator or the like.
상기 추출 용매로는 물(정제수), 탄소수 1 내지 4의 저급 알코올 또는 이들의 혼합 용매로부터 선택된 극성용매를 사용할 수 있으며, 바람직하게는 메탄올을 사용한다.As the extraction solvent, a polar solvent selected from water (purified water), a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof may be used, and preferably methanol is used.
상기 추출 용매의 양은 자스민 건조 중량의 2 ~ 10 배로 한다.The amount of the extraction solvent is 2 to 10 times the dry weight of jasmine.
상기 추출 방법은 중탕 추출, 환류냉각 추출, 초음파 추출 등의 추출 방법을 사용할 수 있으며, 바람직하게는 중탕 추출의 추출방법으로 1회 내지 5회 추출될 수 있다.The extraction method may be an extraction method such as water bath extraction, reflux cooling extraction, ultrasonic extraction, etc., preferably may be extracted 1 to 5 times as an extraction method of water bath extraction.
상기 침적 온도는 30 ~ 70℃ 이며, 보다 바람직하게는 40 ~ 60℃이며, 가장 바람직하게는 50℃ 정도로 유지하는 것이 부패, 변색 및 변취의 예방에 가장 효과적이다.The deposition temperature is 30 ~ 70 ℃, more preferably 40 ~ 60 ℃, most preferably maintained at about 50 ℃ is most effective in the prevention of decay, discoloration and odor.
상기 침적 시간은 5 ~ 20 시간이며, 바람직하게는 10 시간이다.The deposition time is 5 to 20 hours, preferably 10 hours.
상기 자스민 추출물을 수득한 후, 거름종이 등을 이용하여 고형분을 제거하고, 현탁액을 원심분리시키고, 상층액을 감압 여과할 수 있다.After the jasmine extract is obtained, the solids may be removed using a filter paper, the suspension may be centrifuged, and the supernatant may be filtered under reduced pressure.
상기 여과된 추출물을 진공회전농축기로 20 ~ 100℃, 바람직하게는 50 ~ 70℃에서 감압 농축할 수 있다.The filtered extract may be concentrated under reduced pressure at 20 ~ 100 ℃, preferably 50 ~ 70 ℃ with a vacuum rotary concentrator.
본 발명에 의한 자스민 추출물의 효능을 실험한 결과, 멜라닌 생성 세포에 의한 멜라닌 생성을 감소시킴으로서 미백효과가 있으며(실험예 1-2), 세포 독성이 적음을 확인하였다(실험예 2). 따라서, 본 발명의 자스민 추출물은 세포에 독성을 일으키지 않으면서, 멜라닌의 생성을 억제하여 미백 효과를 나타낼 수 있으므로 피부 미백용 조성물로 유용하게 사용될 수 있다.As a result of testing the efficacy of the jasmine extract according to the present invention, by reducing the melanin production by melanin-producing cells has a whitening effect (Experimental Example 1-2), it was confirmed that the cytotoxicity is less (Experimental Example 2). Therefore, the jasmine extract of the present invention can be usefully used as a composition for skin whitening because it can exhibit a whitening effect by inhibiting the production of melanin without causing toxicity to cells.
본 발명에 따른 조성물은 경구, 비경구 사용이 가능하며, 비경구 사용시 피부에 도포하는 방법이 사용될 수 있으며, 제형에 따라 바람직한 사용 방법을 선택할 수 있다.The composition according to the present invention can be used orally or parenterally, the method of applying to the skin during parenteral use can be used, and the preferred method of use can be selected according to the dosage form.
또 다른 관점으로서, 본 발명의 자스민 추출물은 피부학적으로 허용된 담체 와 혼합하여 화장용 조성물로서 제공될 수 있다. 본 발명의 조성물에서 상기 자스민 추출물은 조성물 총 중량에 대하여 0.001 ~ 50 중량%의 양으로 함유될 수 있다.As another aspect, the jasmine extract of the present invention may be provided as a cosmetic composition by mixing with a dermatologically acceptable carrier. The jasmine extract in the composition of the present invention may be contained in an amount of 0.001 to 50% by weight based on the total weight of the composition.
본 발명의 자스민 추출물을 함유하는 화장용 조성물로부터 제조되는 화장품은 일반적인 유화 제형 및 가용화 제형의 형태로 제조할 수 있다. 유화 제형의 화장품으로는 영양화장수, 크림, 에센스 등이 있으며, 가용화 제형의 화장품으로는 유연화장수가 있다. 또한, 본 발명의 자스민 추출물을 함유하는 화장품 이외에도 피부학적으로 허용된 매질 또는 기제를 함유함으로써 피부학 분야에서 통상적으로 사용되는 국소 적용 또는 전신 적용할 수 있는 보조제 형태로 제조될 수도 있다.Cosmetics prepared from the cosmetic composition containing the jasmine extract of the present invention can be prepared in the form of general emulsion formulations and solubilized formulations. Cosmetics of the emulsified formulations include nutrient cosmetics, creams, essences, etc., and cosmetics of the solubilized formulations are flexible cosmetics. In addition to cosmetics containing the jasmine extract of the present invention, it may be prepared in the form of adjuvants that can be applied topically or systemically, which are commonly used in the field of dermatology by containing a dermatologically acceptable medium or base.
적합한 화장품의 제형으로는 예를 들면, 용액, 겔, 고체 또는 반죽 무수 생성물, 수상에 유상을 분산시켜 얻은 에멀젼, 현탁액, 마이크로에멀젼, 마이크로캡슐, 미세과립구 또는 이온형(리포좀), 비이온형의 소낭 분산제의 형태, 크림, 스킨, 로션, 파우더, 연고, 스프레이 또는 콘실 스틱(conceal stick)의 형태로 제공될 수 있다. 또한, 포말(foam)의 형태 또는 압축된 추진제를 더 함유한 에어로졸 조성물의 형태로도 제조될 수 있다.Suitable cosmetic formulations include, for example, emulsions, suspensions, microemulsions, microcapsules, microgranules or ionics (liposomes), nonionics obtained by dispersing an oil phase in a solution, gel, solid or pasty anhydrous product, aqueous phase. It may be provided in the form of a vesicle dispersant, in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. It may also be prepared in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.
목적한 제형에 따라 이용할 수 있는 "피부학적으로 허용된 담체"는 정제수, 오일, 왁스, 지방산, 지방산 알코올, 지방산 에스테르, 계면활성제, 흡습제(humectant), 증점제(thickening agent), 항산화제, 점도 안정화제(viscosity stabilizer), 킬레이팅제, 완충제, 방부제, 저급 알코올 등이 포함되지만, 이에 제한되는 것은 아니며, 그 종류와 농도는 다양하고, 당업자가 본 발명의 사상 및 영역으로부터 벗어나지 않는 범위 내에서 수정 및 변경할 수 있는 부분을 포함한다. 필요에 따라 미백제, 보습제, 항염증제, 항박테리아제, 항진균제, 비타민, 자외선 차단제, 항생제, 여드름 방지제, 향수, 염료가 포함될 수도 있으며, 이들은 화장품 분야에서 통상적으로 사용되는 양으로 본 발명에 따른 화장용 조성물에 포함될 수 있다. 조성물 총 중량 당 0.001 내지 50 중량%가 적합하다.“Dermatologically acceptable carriers” that can be used according to the desired formulation include purified water, oils, waxes, fatty acids, fatty alcohols, fatty acid esters, surfactants, humectants, thickening agents, antioxidants, and viscosity stabilizers. Examples include, but are not limited to, topical stabilizers, chelating agents, buffers, preservatives, lower alcohols, and the like, and their types and concentrations are varied and modifications may be made by those skilled in the art without departing from the spirit and scope of the present invention. And parts that can be changed. If necessary, a whitening agent, a moisturizer, an anti-inflammatory agent, an antibacterial agent, an antifungal agent, a vitamin, a sunscreen agent, an antibiotic, an anti-acne agent, a perfume, a dye may be included, and these are cosmetic compositions according to the present invention in amounts commonly used in the cosmetic field. Can be included. Suitable from 0.001 to 50% by weight per total weight of the composition.
구체적으로 상기 오일로는 수소화 식물성유, 파마자유, 면실유, 올리브유, 야자인유, 호호바유, 아보카도유가 이용될 수 있고, 왁스로는 밀랍, 경랍, 카르나우바, 칸델릴라, 몬탄, 세레신, 액체 파라핀, 라놀린이 이용될 수 있다. 지방산으로는 스테아르산, 리놀레산, 리놀렌산, 올레산이 이용될 수 있고, 지방산 알코올로는 세틸 알코올, 옥틸 도데칸올, 올레일 알코올, 판텐올, 라놀린 알코올, 스테아릴 알코올, 헥사데칸올이 이용될 수 있으며, 지방산 에스테르로는 이소프로필 미리스테이트, 이소프로필 팔미테이트, 부틸 스테아레이트 등이 이용될 수 있지만, 이에 제한되는 것은 아니다.Specifically, the oil may be hydrogenated vegetable oil, perm oil, cottonseed oil, olive oil, palm oil, jojoba oil, avocado oil, wax, beeswax, carnauba, candelilla, montan, ceresin, liquid paraffin Lanolin may be used. Stearic acid, linoleic acid, linolenic acid, oleic acid may be used as a fatty acid, cetyl alcohol, octyl dodecanol, oleyl alcohol, pantenol, lanolin alcohol, stearyl alcohol, hexadecanol may be used as a fatty acid. As the fatty acid ester, isopropyl myristate, isopropyl palmitate, butyl stearate and the like may be used, but is not limited thereto.
계면활성제의 예로는 소듐 스테아레이트, 소듐 세틸설페이트, 폴리옥시에틸렌 라우릴에테르 포스페이트, 소듐 N-아실 글루타메이트와 같은 음이온 계면활성제; 스테아릴디메틸벤질암모늄 클로라이드 및 스테아릴트리메틸암모늄 클로라이드와 같은 양이온 계면활성제; 알킬아미노에틸글리신 하이드로클로라이드 및 레시틴과 같은 양성 계면활성제; 글리세린 모노스테아레이트, 소르비탄 모노스테아레이트, 프로필렌 글리콜 모노스테아레이트, 폴리옥시에틸렌 올레일에테르, 폴리에틸렌 글리콜 모노스테아레이트, 폴리옥시에틸렌 소르비탄 모노팔미테이트, 폴리옥시에틸렌 코코넛 지방산 모노에탄올아르니드(monoethaolarnide), 폴리옥시프로필렌 글리 콜, 폴리옥시에틸렌 캐스터유, 폴리옥시에틸렌 라놀린과 같은 비이온성 계면활성제 등이 포함된다.Examples of the surfactant include anionic surfactants such as sodium stearate, sodium cetyl sulfate, polyoxyethylene laurylether phosphate, sodium N-acyl glutamate; Cationic surfactants such as stearyldimethylbenzylammonium chloride and stearyltrimethylammonium chloride; Amphoteric surfactants such as alkylaminoethylglycine hydrochloride and lecithin; Glycerine monostearate, sorbitan monostearate, propylene glycol monostearate, polyoxyethylene oleyl ether, polyethylene glycol monostearate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene coconut fatty acid monoethanol arnide (monoethaolarnide ), Polyoxypropylene glycol, polyoxyethylene castor oil, nonionic surfactants such as polyoxyethylene lanolin and the like.
흡습제에는 글리세린, 1,3-부틸렌 글리콜, 프로필렌 글리콜이 이용될 수 있으며, 저급 알코올로는 에탄올, 이소프로판올이 이용 가능하다. 증점제의 예에는 알긴산 나트륨, 카제인산 나트륨, 젤라틴 한천, 크산탄 고무, 전분, 셀룰로오스 에테르 (예, 하이드록시에틸 셀룰로오스, 메틸 셀룰로오스, 카르복시메틸 셀룰로오스, 하이드록시 프로필메틸 셀룰로오스), 폴리비닐 피롤리돈, 폴리비닐 알코올, 폴리에틸렌 글리콜 및 소듐 카르복시메틸 셀룰로오스 등이 포함되지만, 이에 제한되는 것은 아니다. 항산화제로는 부틸레이티드 하이드록시톨루엔, 부틸레이티드 하이드록시아니솔, 프로필 갈레이트, 시트르산, 에톡시퀸(ethoxyquin)이 이용 가능하고, 킬레이팅제로는 디소듐 에데테이트, 에탄하이드록시 디포스페이트가 이용 가능하며, 완충제로는 시트르산, 소듐 시트레이트, 붕산, 보랙스(borax), 디소듐 하이드로젠 포스페이트가 이용 가능하고, 방부제로는 메틸 파라하이드록시벤조에이트, 에틸 파라하이드록시벤조에이트, 디하이드로아세트산, 살리실산, 벤조산이 이용 가능하지만, 이에 제한되는 것은 아니다.Glycerin, 1,3-butylene glycol, propylene glycol may be used as the moisture absorbent, and ethanol or isopropanol may be used as the lower alcohol. Examples of thickeners include sodium alginate, sodium caseate, gelatin agar, xanthan gum, starch, cellulose ethers (e.g., hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxy propylmethyl cellulose), polyvinyl pyrrolidone, Polyvinyl alcohol, polyethylene glycol, sodium carboxymethyl cellulose, and the like, but are not limited thereto. As antioxidants, butylated hydroxytoluene, butylated hydroxyanisole, propyl gallate, citric acid, ethoxyquin can be used, and chelating agents include disodium edetate and ethane hydroxy diphosphate. Citric acid, sodium citrate, boric acid, borax, disodium hydrogen phosphate are available as buffers, and methyl parahydroxybenzoate, ethyl parahydroxybenzoate, dihydro as preservatives. Acetic acid, salicylic acid, benzoic acid are available, but are not limited to these.
본 발명의 조성물은 상기 자스민 추출물에 추가로 동일 또는 유사한 기능을 나타내는 피부 미백 활성 성분을 1종 이상 함유할 수 있다. 피부 미백 활성 성분으로는 코지산 및 이의 유도체, 알부틴, 아스코르브산 및 이의 유도체, 하이드로퀴논 및 이의 유도체, 레조르시놀, 사이클로알카논, 메틸렌디옥시페닐 알칸올, 2,7-디니트로인다졸, 덩굴귤 추출물, 쌀 추출물, 감초 추출물과 같은 식물 추출물 등이 있지만, 이에 제한되는 것은 아니다.The composition of the present invention may contain one or more skin whitening active ingredients exhibiting the same or similar function in addition to the jasmine extract. Skin whitening active ingredients include kojic acid and its derivatives, arbutin, ascorbic acid and its derivatives, hydroquinone and its derivatives, resorcinol, cycloalkanone, methylenedioxyphenyl alkanol, 2,7-dinitroindazole, Plant extracts such as vine tangerine extract, rice extract, licorice extract, and the like, but are not limited thereto.
본 발명의 화장용 조성물을 첨가할 수 있는 제품으로는, 예를 들어, 수렴화장수, 유연화장수, 영양화장수, 각종 크림, 에센스, 팩, 파운데이션 등과 같은 화장품류와 클렌징, 세안제, 비누, 트리트먼트, 미용액 등이 있다.Examples of products to which the cosmetic composition of the present invention may be added include, for example, cosmetics such as astringent cosmetics, soft cosmetics, nourishing cosmetics, various creams, essences, packs, foundations, cleansing agents, face washes, soaps, treatments, Essence and the like.
본 발명의 화장용 조성물의 구체적인 제형으로서는 스킨로션, 스킨 소프너, 스킨토너, 아스트린젠트, 로션, 밀크로션, 모이스처 로션, 영양로션, 맛사지크림, 영양크림, 모이스처 크림, 핸드크림, 에센스, 영양에센스, 팩, 비누, 샴푸, 클렌징폼, 클렌징로션, 클렌징크림, 바디로션, 바디클렌저, 유액, 프레스파우더, 루스파우더, 아이섀도 등의 제형을 포함한다.Specific formulations of the cosmetic composition of the present invention include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack Formulations such as soaps, shampoos, cleansing foams, cleansing lotions, cleansing creams, body lotions, body cleansers, emulsions, press powders, loose powders, eye shadows and the like.
또 다른 관점으로서, 본 발명의 자스민 추출물은 식품학적으로 허용된 담체와 혼합하여 식품 조성물로서 제공될 수 있다. 본 발명의 자스민 추출물을 식품 또는 음료 첨가물로 사용할 경우, 상기 자스민 추출물을 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용되고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 상기 자스민 추출물의 혼합양은 그의 사용목적(예방, 건강 또는 치료적 처치)에 따라 적합하게 결정될 수 있다.As another aspect, the jasmine extract of the present invention may be provided as a food composition by mixing with a food acceptable carrier. When the jasmine extract of the present invention is used as a food or beverage additive, the jasmine extract may be added as it is or used with other food or food ingredients, and may be appropriately used according to a conventional method. The mixed amount of the jasmine extract may be appropriately determined depending on the purpose of use (prevention, health or therapeutic treatment).
건강 및 위생을 목적으로 하거나 또는 건강조절을 목적으로 하는 장기간의 섭취의 경우, 상기 자스민 추출물은 안전성 면에서 아무런 문제가 없기 때문에, 장기간 복용이 가능하다.In the case of long-term intake for health and hygiene or health control, the jasmine extract can be taken for a long time because there is no problem in terms of safety.
상기 식품의 종류에는 특별한 제한은 없다. 상기 물질을 첨가할 수 있는 식 품의 예로는 육류, 소세지, 빵, 초콜릿류, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알코올 음료 및 비타민 복합제 등이 있다.There is no particular limitation on the kind of food. Examples of foods to which the above substances can be added include dairy products including meat, sausages, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, ice cream, various soups, drinks, tea, and drinks. Alcoholic beverages and vitamin complexes.
음료수로 제형화할 경우에 자스민 추출물 이외에 첨가되는 액체 성분으로는 이제 한정되지는 않으나, 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상술한 천연 탄수화물의 예는 모노사카라이드 (예, 포도당, 과당 등), 디사카라이드 (예, 말토오스, 수크로오스 등) 및 폴리사카라이드 (예, 덱스트린, 시클로덱스트린 등과 같은 통상적인 당), 및 자일리톨, 소르비톨, 에리스리톨 등의 당 알코올이다. 상기 천연 탄수화물의 비율은 본 발명의 조성물 100㎖당 일반적으로 약 1 내지 20g, 바람직하게는 약 5 내지 12g이다. 상술한 것 이외의 향미제로서 천연 향미제[타우마린, 스테비아 추출물 (예, 레바우디오시드 A, 글리시르히진 등)] 및 합성 향미제(예, 사카린, 아스파르탐 등)를 사용할 수 있다.The liquid component added in addition to the jasmine extract when formulated into a beverage is not limited to now, but may contain various flavors or natural carbohydrates, etc. as additional ingredients, as in conventional beverages. Examples of the above-mentioned natural carbohydrates include monosaccharides (e.g. glucose, fructose and the like), disaccharides (e.g. maltose, sucrose and the like) and polysaccharides (e.g. conventional sugars such as dextrin, cyclodextrin and the like), and xylitol Sugar alcohols such as sorbitol and erythritol. The proportion of said natural carbohydrates is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention. As flavoring agents other than those mentioned above, natural flavoring agents (taumarin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (e.g., saccharin, aspartame, etc.) can be used. .
다른 양태로서, 본 발명의 식품 조성물은 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 증진제 (치즈, 초콜릿 등), 펙트산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산 음료에 사용되는 탄산화제 등을 함유할 수 있다. 또한, 본 발명의 식품 조성물은 과일 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 단독으로 또는 조합으로 사용될 수 있으며, 이러한 첨가제의 비율은 조성물 전체 중량당 0.001 내지 50 중량%의 범위에서 선택되는 것이 일반적이다.In another embodiment, the food composition of the present invention comprises various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic and natural flavors, colorants and enhancers (such as cheese, chocolate), pectic acid and salts thereof, organic acids , Protective colloid thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. The food composition of the present invention may also contain pulp for the production of fruit and vegetable drinks. These components may be used alone or in combination, and the proportion of such additives is generally selected in the range of 0.001 to 50% by weight based on the total weight of the composition.
본 발명에 따른 자스민 추출물은 세포에 독성을 일으키지 않으면서, 멜라닌의 생성을 억제하여 미백 효과를 나타내기 때문에 피부 미백용 조성물로 유용하게 사용될 수 있다.Jasmine extract according to the present invention can be usefully used as a composition for skin whitening because it exhibits a whitening effect by inhibiting the production of melanin without causing toxicity to cells.
이하, 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로서, 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.Hereinafter, the examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these examples in accordance with the gist of the present invention, those skilled in the art. Will be self-evident.
<실시예: 피부 미백용 자스민 추출물의 제조>Example: Preparation of Jasmine Extract for Skin Whitening
본 실시예의 자스민은 중국의 고산지방에서 채취한 것을 사용하였다.Jasmine of this example was taken from the high mountain region of China.
채취한 식물 50 g을 100% 메탄올 200 ㎖에 침지시켜 50℃ 수욕조에서 10시간 동안 온탕하였다. 얻어진 추출액을 실온으로 냉각시키고 거름종이로 여과하여 여과액을 취하였다. 질소를 사용하여 여과액에서 메탄올을 증발시켜 농축한 다음, 이를 10% 메탄올에 녹여 추출물을 제조하였다.50 g of the collected plant was immersed in 200 ml of 100% methanol and warmed in a 50 ° C. water bath for 10 hours. The obtained extract was cooled to room temperature and filtered through a filter paper to give a filtrate. Methanol was evaporated from the filtrate using nitrogen, concentrated and then dissolved in 10% methanol to prepare an extract.
<실험예 1: 미백 효과 측정>Experimental Example 1: Measurement of the Whitening Effect
1-1: B16 멜라노마 세포 배양1-1: B16 Melanoma Cell Culture
B16 멜라노마 세포는 수원 임업 연구소에서 제공받아 배양시켰다. B16 멜라노마 세포는 멜라닌을 생성하는 세포주로서 일반적으로 미백물질 스크리닝에 사용된다. B16 melanoma cells were provided by Suwon Forest Research Institute and cultured. B16 melanoma cells are cell lines producing melanin and are commonly used for whitening screening.
상기 세포를 배양하기 위한 배지는 DMEM, 10% FBS, 1% 페니실린/스트렙토마이신을 넣어 무균상태로 만들었다. 세포배양은 37℃, 5% CO2의 인큐베이터에서 배양하였다. 멜라노마 세포를 배양하여 100 mm 패트리 디쉬가 90% 정도 찼을 때 계대하였다.The medium for culturing the cells was sterile by adding DMEM, 10% FBS, 1% penicillin / streptomycin. Cell cultures were incubated in an incubator at 37 ° C., 5% CO 2 . Melanoma cells were cultured and passaged when the 100 mm Petri dishes were about 90% full.
1-2: 흡광도 측정을 이용한 멜라닌 저해 측정1-2: melanin inhibition measurement using absorbance measurement
자스민 추출물의 미백효과 측정을 위하여 B16 멜라노마 세포에 처리하여 생성된 멜라닌 양의 변화를 측정하였다. 6 웰 플래이트에 세포를 접종(seeding)하고 실시예에서 제조한 자스민 추출물을 200 ㎍/㎖ 농도로 처리한 후 이틀간 배양하여 세포를 회수하였다. 회수한 세포를 10% DMSO를 포함하는 1N NaOH를 가해 90℃에서 1 시간 반응시켜 멜라닌에 충분히 녹아나오도록 한 후, ELISA 리더(reader)를 이용하여 파장 405nm에서 흡광도를 측정하였다.In order to measure the whitening effect of jasmine extract, the amount of melanin produced by treating B16 melanoma cells was measured. Cells were seeded on the 6 well plate and treated with the jasmine extract prepared in Example at a concentration of 200 μg / ml, and then cultured for 2 days to recover the cells. The recovered cells were added with 1N NaOH containing 10% DMSO, reacted at 90 ° C for 1 hour to be sufficiently dissolved in melanin, and then absorbance was measured at a wavelength of 405 nm using an ELISA reader.
실험은 총 3회 실시하였고, 멜라닌 생성도는 하기 수학식 1을 이용하여 계산하였으며, 표 1에 나타내었다. 일반적인 미백물질로 알려진 알부틴의 경우 미처리 구와 비교했을 때, 200 ㎍/㎖의 농도에서 멜라닌 양이 71.4%인 것에 반해, 자스민 추출물은 78.3%로 알부틴과 비슷한 정도의 멜라닌 생성 저해효과를 가짐을 확인할 수 있었다. The experiment was performed a total of three times, melanin production was calculated using Equation 1 shown in Table 1. Arbutin, a known whitening substance, was 71.4% of melanin at a concentration of 200 ㎍ / ml, while jasmine extract had 78.3% of melanin-inhibiting effect, similar to that of arbutin. there was.
<실험예 2: 독성 실험>Experimental Example 2: Toxicity Test
자스민 추출물의 미백 화장료로 사용하기 위하여, 세포 독성 여부를 확인하기 위한 실험을 하였다. 96 웰 플래이트에 세포를 접종하고 자스민 추출물 200 ㎍/㎖을 처리하고 이틀 후 배지를 제거하고 MTT 용액을 100㎕ 첨가하여 30℃에서 4시간 반응 후 용액을 제거하고 DMSO 100㎕를 첨가하여 염색된 세포를 녹인 후 ELISA 리더(reader)를 이용하여 파장 540nm에서 흡광도를 측정하였다In order to use as a whitening cosmetic of jasmine extract, an experiment was carried out to check for cytotoxicity. Cells were inoculated into 96 well plates, treated with 200 ㎍ / ml of jasmine extract, and after 2 days, the medium was removed, 100 μl of MTT solution was added, and the solution was removed after 4 hours at 30 ° C., and 100 μl of DMSO was added to stain the cells. After melting, absorbance was measured at a wavelength of 540 nm using an ELISA reader.
실험은 총 3회 실시하였고, 세포 생존율은 하기 수학식 2를 이용하여 계산하였으며, 표 2에 나타내었다. 자스민 추출물을 처리하지 않은 세포와 비교하였을 때, 200 ㎍/㎖의 높은 농도임에도 불구하고 생존 세포율이 103.7%로 세포독성이 없음을 알 수 있다. The experiment was performed three times in total, and cell viability was calculated using Equation 2 below. Compared with the cells treated with the jasmine extract, despite the high concentration of 200 ㎍ / ㎖, it can be seen that there is no cytotoxicity with a viable cell rate of 103.7%.
하기에 본 발명의 조성물을 위한 제제예를 예시한다.Examples of formulations for the composition of the present invention are illustrated below.
<제제예 1: 유연 화장수><Example 1: Flexible lotion>
자스민 추출물을 함유한 유연 화장수의 제제예는 다음 표 3의 조성과 같이 제조하였다.Formulation example of the flexible lotion containing jasmine extract was prepared as shown in Table 3.
<제제예 2: 영양 크림><Example 2: Nutritional Cream>
자스민 추출물을 함유한 영양크림의 제제예는 다음 표 4의 조성과 같이 제조하였다.Formulation of nutrition cream containing jasmine extract was prepared as shown in Table 4.
<제제예 3 : 식품의 제조>Preparation Example 3 Preparation of Food
본 발명의 자스민 추출물을 함유하는 식품들을 다음과 같이 제조하였다.Foods containing the jasmine extract of the present invention were prepared as follows.
3-1. 밀가루 식품의 제조3-1. Manufacture of Flour Food
본 발명의 자스민 추출물 0.5∼5.0 중량부를 밀가루에 첨가하고, 이 혼합물을 이용하여 빵, 케이크, 쿠키, 크래커 및 면류를 제조하여 건강 증진용 식품을 제조하였다.0.5-5.0 parts by weight of jasmine extract of the present invention was added to the flour, and bread, cake, cookies, crackers and noodles were prepared using the mixture to prepare foods for health promotion.
3-2. 유제품(dairy products)의 제조3-2. Manufacture of dairy products
본 발명의 자스민 추출물 5 ∼ 10 중량부를 우유에 첨가하고, 상기 우유를 이용하여 버터 및 아이스크림과 같은 다양한 유제품을 제조하였다.5-10 parts by weight of the jasmine extract of the present invention was added to milk, and various dairy products such as butter and ice cream were prepared using the milk.
3-3. 선식의 제조3-3. Manufacture of wire
현미, 보리, 찹쌀, 율무를 공지의 방법으로 알파화시켜 건조시킨 것을 배전한 후 분쇄기로 입도 60메쉬의 분말로 제조하였다.Brown rice, barley, glutinous rice, and yulmu were alphad by a known method, and then dried and roasted to prepare a powder having a particle size of 60 mesh using a grinder.
검정콩, 검정깨, 들깨도 공지의 방법으로 쪄서 건조시킨 것을 배전한 후 분쇄기로 입도 60메쉬의 분말로 제조하였다.Black beans, black sesame seeds, and perilla were also steamed and dried by a known method, and then ground to a powder having a particle size of 60 mesh.
본 발명의 자스민 추출물을 진공 농축기에서 감압·농축하고, 분무, 열풍건조기로 건조하여 얻은 건조물을 분쇄기로 입도 60메쉬로 분쇄하여 건조분말을 얻었다.The jasmine extract of the present invention was decompressed and concentrated in a vacuum concentrator, and the dried product obtained by drying with a sprayer and a hot air dryer was pulverized with a particle size of 60 mesh to obtain a dry powder.
상기에서 제조한 곡물류, 종실류 및 자스민 추출물의 건조분말을 다음의 비율로 배합하여 제조하였다.It was prepared by combining the dry powder of the grains, seeds and jasmine extract prepared in the following ratio.
곡물류(현미 30중량부, 율무 15중량부, 보리 20중량부),Cereals (30 parts by weight brown rice, 15 parts by weight of radish, 20 parts by weight of barley),
종실류(들깨 7중량부, 검정콩 8중량부, 검정깨 7중량부),Seeds (7 parts by weight perilla, 8 parts by weight black beans, 7 parts by weight black sesame seeds),
자스민 추출물의 건조분말(3 중량부),Dry powder of jasmine extract (3 parts by weight),
영지(0.5중량부),Ganoderma lucidum (0.5 parts by weight),
지황(0.5중량부)Foxglove (0.5 weight part)
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US20130338241A1 (en) * | 2010-12-23 | 2013-12-19 | Charabot | Process for obtaining a scented extract of fresh flowers and/or leaves using natural solvents |
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2008
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US20130338241A1 (en) * | 2010-12-23 | 2013-12-19 | Charabot | Process for obtaining a scented extract of fresh flowers and/or leaves using natural solvents |
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