KR20100040696A - Method for deodorizing smell derived from processed aloe products - Google Patents

Abstract

PURPOSE: A method for deodorizing smell derived from processed aloe products is provided, which can remove unpleasant smell of the processed product. CONSTITUTION: A method for deodorizing smell derived from processed aloe products comprises: a step of mixing aloe concentrate 950 g, lactose 2,150 g, crystalline cellulose 500 g, and hard silicon dioxide 75 g; a step of assembling, drying, and regulating by adding 6% hydroxypropyl cellulose aqueous solution 600 g to the mixture; a step of forming granules by adding magnesium stearate 40 g; and a step of manufacturing tablets by compressing the granules.

Description

Deodorizing method derived from aloe artifact {METHOD FOR DEODORIZING SMELL DERIVED FROM PROCESSED ALOE PRODUCTS}

The present invention provides a method for deodorizing the aloe-derived odor generated when a solid preparation containing an aloe processed product is stored for a long time at high temperatures, and a odor derived from the aloe processed product generated when the solid preparation containing the aloe processed product is stored for a long time at a high temperature. And a package packaged by the packaging method.

Aloe processed products are known to have a lowering action, health, hypoglycemic action, anti-inflammatory action, defense against radiation and skin disorders. In addition, for the purpose of increasing the efficacy of the aloe processed product, for example, a formulation for combining Plantago ovata and glycosylated bacteria (Patent Document 1), a formulation for blending Senna (Patent Document 2), catechins, The formulation which mixes horse oil (following patent document 3), etc. are known. As described above, the aloe processed product has various uses and has been blended into some medicines. However, since the aloe processed product has an unusual smell, there is a problem in that resistance to oral ingestion is felt.

Therefore, various means are examined in order to reduce the smell of aloe processed material. For example, an aloe drink (patent document 4) in which coffee is blended with a dried aloe decoction liquid, an aloe drink obtained by dipping aloe together with a sweetener and citric acid (patent document 5), and the like are known.

However, these methods are a method of suppressing the smell of aloe to drinks, and there have been no reports on the method of suppressing the unpleasant smell in solid preparations containing aloe processed products.

[Patent Document 1] Japanese Unexamined Patent Publication No. 2008-120719

[Patent Document 2] Japanese Patent Application Laid-Open No. 11-180884

[Patent Document 3] Japanese Unexamined Patent Publication No. 2002-003388

[Patent Document 4] Japanese Patent Application Laid-Open No. 2000-262257

[Patent Document 5] Japanese Patent Laid-Open No. 2006-230265

The inventors of the present invention have studied solid preparations containing aloe processed products and have found that an unpleasant odor occurs over time when stored at high temperatures for a long time. This unpleasant odor is a peculiar odor derived from aloe processed material, which is resistant to oral ingestion, and this unpleasant odor greatly reduces the value of the product. That is, the subject of this invention is providing the method of deodorizing the unpleasant odor derived from the aloe processed material which arises when the solid preparation containing an aloe processed material is preserve | saved for a long time at high temperature.

MEANS TO SOLVE THE PROBLEM As a result of earnestly researching in order to solve the said subject, when the solid formulation containing an aloe processed product was sealed with a desiccant in a closed system, even if it stored for a long time at high temperature, the unpleasant smell derived from an aloe processed product was found to be deodorized. Thus, the present invention has been completed.

That is, the present invention provides a method for deodorizing an aloe-derived odor, characterized in that the solid preparation containing the aloe processed product and the drying agent are stored in a closed system.

The present invention also provides a method for packaging a solid preparation and a package packaged by the method, wherein the solid preparation containing the aloe processed product and the drying agent are stored in a closed system.

According to the present invention, even when stored at a high temperature for a long time, an unpleasant odor derived from an aloe processed product is deodorized, so that an aloe processed product-containing solid preparation excellent in commodity value can be provided.

The aloe processed material used in the present invention is a plant having the scientific name of Aloe ferox Miller, or a hybrid plant of Aloe perox Miller and Aloe africana Miller or Aloe spicata Baker. It means that it is obtained by processing the site | part containing Barbaloin, such as a leaf, a stem, and a root of (Liliaceae).

As the processing treatment, for example, raw aloe may be dried and powdered, extracted with steam distillation, oil, water, hot water or a water-soluble organic solvent, or heated. Examples of oils used for extraction include edible vegetable oils such as rapeseed oil, olive oil and soybean oil. Examples of the water-soluble organic solvents include lower alcohols such as ethanol and isopropanol; Glycols, such as propylene glycol and diethylene glycol, etc. are mentioned.

The aloe processed product is not particularly limited as long as it has been subjected to the above treatment, but aloe powder, aloe extract, aloe concentrate, dried aloe and the like are preferred, and aloe concentrate or aloe powder is particularly preferred. Such aloe processed products are commercially available products (for example, aloe concentrate (Koshiro Seiyaku Co., Ltd.), aloe dry concentrate (Nippon-Hunmatsu Yakuhin Co., Ltd.), Nikkyoku aloe powder (Nippon Hunmatsu Co., Ltd.), Koshiro It is available as Seiyaku Co., Ltd., Alpine Yakuhin Co., Ltd.), and aloe softening concentrate (Nipbon Hunmatsu Co., Ltd.).

Although content of the aloe processed material in the solid preparation of this invention can be suitably set according to the disease, symptom, formulation, etc. which are made into object, 1-80 mass% is preferable with respect to the total mass of solid preparation from a pharmacological effect viewpoint, and 5-55 mass % Is more preferable, and 15-35 mass% is especially preferable.

The desiccant in the present invention is not particularly limited as long as it is a desiccant commonly used in medicines, foods, and the like, but for example, silica gel, silica alumina gel (allofen), natural zeolite, synthetic zeolite (molecular sieve), calcium chloride, quicklime (calcium oxide) And bentonite clay (montmorillonite), and the like, and one or two or more of them can be used in combination.

In addition, while a desiccant is generally known to be an adsorbent for water molecules, there has been no report on the action of deodorizing an unpleasant odor derived from an aloe processed product as in the present invention. The amount of the desiccant in the present invention is not particularly limited, but may be 0.001 to 10 parts by mass, preferably 0.01 to 1.0 part by mass, and more preferably 0.01 to 0.5 part by mass based on 1 part by mass of the aloe workpiece.

In the solid preparation according to the present invention, an active ingredient other than an aloe processed product can also be appropriately blended according to its purpose of use. Such components include, for example, vitamins, intestinal probiotics, laxatives, antacids, healthy agents, digestive agents, intestinal agents, anti-diarrheal agents, analgesic and economical mucosa and gastric mucosal repair agents, and may include one or two or more of them. have.

As vitamins, for example, nicotinic acid amide, calcium pantothenate, biotin, vitamin B1 and its derivatives and salts thereof, vitamin B2 and its derivatives and salts thereof, vitamin B6 and its derivatives and their salts and vitamin C and derivatives thereof And these salts etc. can be mentioned, These can be used 1 type or in combination or 2 or more types. More preferable vitamins include calcium pantothenate and / or vitamin B6 and derivatives thereof and salts thereof.

As the bacteriostatic bacteria, for example, lactomin (Pecharis bacillus, Ashdophyllus bacillus, Kaseri bacillus, Bulgarian bacterium, etc.), bifidus bacillus, butyric acid bacterium (such as Bacillus bacillus), diffuser lactic acid bacterium (such as lacbon base) and Bacillus subtilis (Glycosylated bacteria, natto bacteria, etc.), and one or two or more thereof can be used in combination. More preferable microbial bacteria include butyric acid bacteria and / or natto bacteria.

As a laxative, for example, salt laxatives, such as magnesium oxide, magnesium hydroxide, magnesium carbonate, sodium sulfate, and magnesium sulfate, swellable laxatives such as carboxymethyl cellulose calcium, sodium carboxymethyl cellulose, and plantago obata seeds, dioctyl sodium sulfosuccinate Wetting laxatives such as sulfur, sulfur, casanthranol, sennoside, biskodil, youngsil, cascara sagrada, nut, senna, rhubarb, frangula husk, yalapa and other laxatives, such as castor oil and martz Concentrated liquids; and the like.

As the antacid, for example, dry aluminum hydroxide gel, magnesium aluminate silicate, magnesium silicate, synthetic aluminum silicate, synthetic hydrotalcite, magnesium oxide, magnesium hydroxide, aluminum hydroxide gel, aluminum hydroxide, sodium hydrogen carbonate coprecipitation product, aluminum hydroxide Magnesium carbonate mixed dry gel, aluminum hydroxide, magnesium carbonate, calcium carbonate coprecipitation product, magnesium hydroxide, sodium hydrogen carbonate, magnesium carbonate, precipitated calcium carbonate, magnesium aluminate silicate, anhydrous calcium phosphate, calcium hydrogen phosphate, crust bone, Crystallite name, hairpin, amino acetic acid, dihydroxyaluminum aminoacetate, and a concentrate of liquid.

As a dry agent, for example, anise fruit, fennel, turmeric, ointment, lotus root, golden, yellow white, yellow lotus, processed garlic, ah, pear fennel, iris root, health, crust, fruit, cinnamon, gentiana, red ginseng, black pepper, Osuyu, black pepper, Colombo, Condurango, Sansho, Sanna, Jaja, barn, ginger, soybean paste, green skin, changchanggeun, centurium grass, bitter grass, creation, leaflet, convention incense, rhubarb, bamboo ginseng, cloves, dermis, red pepper , Spruce, animal fences (including ungdam), pine, nutmeg, ginseng, peppermint (including Western mint), essential, white leach, hops, sperm concentrate, watercolor leaf, cedar, ripe, gentian, yangkang, fennel oil, Cinnamon oil, ginger oil, soybean oil, clove oil, ash oil, peppermint oil, lemon oil, l-menthol, dl-menthol, betaine hydrochloride, glutamate, carnitine chloride, betaneca chloride and dry yeast.

Examples of the extinguishing agent include starch digestive enzyme, protein digestive enzyme, fat digestive enzyme, fibrin digestive enzyme, urodesoxycholic acid, oxycholates, cholic acid, bile powder, bile concentrate (powder), dihydrocholic acid and animal bile. (Including ungdam).

Examples of the formal dressing agents include various formal dressing agents such as Yeonderak, subtropical medicinal plants, ume, sedentary, and dysentery.

As the anticorrosive agent, for example, acrinoline, berberine chloride, guayacol, creosote, phenyl salicylate, guayacohol, tannin berberine, bismuth bismuth, bismuth nitric acid, bismuth bicarbonate, bismuth bismuth, tannic acid and tannin acid albumin And methylene thymoltannin, kaolin, hydroxy naphthoate, aluminum, pectin, medicinal charcoal, subline medicinal, ume, yellow and white, rhubarb, red ginseng, algae, gall bladder, hawthorn, bitter grass, and buckthorn.

As analgesic antispasmodic agents, for example, oxyphencycline hydrochloride, dicyclomine hydrochloride, meticene hydrochloride, hydrobromic acid scopolamine, methyl bromide hydrobromide, methyl bromide bromide, methyl bromide bromide, methyl bromide l- -Hiosiamine, methyl benzacthiide bromide, belladonna concentrate, isopropide iodide, diphenyl piperidinomethyldioxolane iodide, papaverine hydrochloride, ethyl aminobenzoate, pale orange, licorice, thick pepper and peony Etc. can be mentioned.

Examples of gastric mucosal restoratives include methylmethioninesulfonium chloride, sodium azulene sulfonate, aldioxa, glycyrrhizin acid and salts and licorice extracts thereof, L-glutamine, copper chlorophyllin potassium, copper chlorophyllin sodium, histidine hydrochloride, pigs Gastric pepsin digest, pork gastric acid hydrolyzate, yeast tree, pale yellow and licorice.

The solid preparations according to the present invention can be prepared using excipients, binders, disintegrants, lubricants, colorants, copulating agents, polishing agents, and the like, as preparation additives.

Examples of the excipient include lactose, starch, crystalline cellulose, sucrose, mannitol, hard silicic acid, and the like. Examples of the binder include hydroxypropyl methyl cellulose, hydroxypropyl cellulose, gelatin, alpha starch, polyvinylpyrrolidone, polyvinyl alcohol, and pullulan. Examples of the disintegrant include carmellose, carmellose calcium, low-substituted hydroxypropyl cellulose, crospovidone, croscarmellose sodium, corn starch and the like. Examples of the lubricant include sucrose fatty acid ester, hardened oil, stearic acid, magnesium stearate and talc. As a coloring agent, a tar pigment | dye, iron trioxide, etc. are mentioned. Examples of the mating agent include stevia, aspartame, l-menthol, d-borneneol and flavorings. Examples of the brightening agent include waxes such as beeswax, carnauba wax, mercury, lecithin, paraffin, and microcrystalline wax.

In addition, the solid preparation according to the present invention may be coated by dragees, film coating or the like. As the coating agent, carboxymethyl ethyl cellulose, cellulose acetate cellulose, methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid copolymer LD, hydroxypropyl methyl cellulose phthalate, hydroxypropyl methyl cellulose acetate succinate and the like can be used. Can be. In forming the film, plasticizers such as triethyl citrate, triacetin and polyethylene glycol, talc, titanium oxide, yellow trioxide, iron trioxide, statutory dyes, hard silicic anhydride and hydrous silicon dioxide and sodium lauryl sulfate You may mix | blend surfactant, such as polysorbate.

Examples of the formulation of the solid preparations according to the present invention include capsules, pills, granules, tablets and powders, and in particular, tablets, in particular film coated tablets, are preferred.

Solid preparations according to the invention can be prepared according to conventional methods. For example, when the dosage form is a tablet, the mixture or granulated product obtained by mixing or granulating based on conventional methods such as the Japanese Pharmacopoeia General Regulations using aloe processed products, various drugs, and various commonly used formulation additives, and lubricants, if desired By mixing and then tableting, the solid preparation according to the present invention can be prepared. In addition, when carrying out film coating of a solid preparation, coating can be performed by the general method, such as apply | coating or spraying a coating liquid. In particular, it is preferable to employ a spray coating method simply.

According to the present invention, the unpleasant odor derived from the aloe processed product can be deodorized by preserving the solid preparation containing the aloe processed product in the form enclosed with the desiccant in a closed system. Since such an unpleasant odor tends to occur especially when stored at high temperature for a long time, it can deodorize an unpleasant odor derived from an aloe processed material at the time of storage under such conditions. The high temperature here means the storage conditions in 30 degreeC or more, and exhibits the effect especially in the storage conditions of 35 degreeC or more.

In order to store a solid preparation in a closed system, a container which can be sealed may be used. In the present invention, the term " preserve the solid preparation and the drying agent containing the aloe processed product in a closed system " means that the solid preparation and the drying agent containing the aloe processed product are sealed and sealed in a sealable container. As a container which can be used by this invention, if there is a container which can maintain a sealed state, there will be no restriction | limiting in particular, For example, things of the form of a bottle, a can, a box, a bag, etc. are mentioned. Moreover, as the material, glass, resin, a metal, etc., what made these materials into a composite structure or a multilayered structure, etc. are mentioned, for example. Furthermore, for example, an aluminum can, an iron can, a glass bottle or a plastic bottle containing a solid preparation and a desiccant, or a pillow-packed or stick-packed product using a sheet suitable for each container packed with PTP or strip may be used. It is an example of form.

The storage method of the desiccant in an airtight container is not particularly limited. For example, if the container is a bottle, a cylindrical (tablet) desiccant is added to the bottle or stored on the back of the bottle, Or if a container is a sealing, sealing in a bag using shaping | molding drying agents, such as a sheet form and a plate form, etc. are mentioned.

In the present invention, the sealed package (container) includes a solid preparation containing aloe processed material and a desiccant, but if it does not prevent the deodorizing action of an unpleasant odor according to the present invention, a known preservative may be further added. You can also enclose it.

The solid preparations of the present invention are used for the purpose of expressing the effects expected in aloe processed products, and can be used, for example, as medicines for the prevention and / or treatment of constipation, elevated blood sugar, inflammation.

<Example>

Although an Example demonstrates this invention concretely below, this invention is not limited to these Examples.

[Production Example 1]

950 g of aloe concentrate, 2,150 g of lactose, 500 g of crystalline cellulose, and 75 g of hard anhydrous silicic acid are mixed, and 600 g of 6% hydroxypropyl cellulose solution is added thereto, followed by granulation, drying, and granulation. 40 g of magnesium stearate is added thereto. Was added to form a tableting granule. The tableting granules were compression molded to produce about 15,000 tablets (250 mg / tablet). In addition, the predetermined immediately after manufacture was odorless.

Example 1

The predetermined 100 obtained in the manufacture example 1 was filled in 5K of white glass bottles, Furthermore, 2.5 g of refined silica gel (PW1810: Yamani Yakuhin Co., Ltd.) was added to the bottle, and the stopper was sealed and the package was obtained.

Comparative Example 1

The predetermined 100 pieces obtained by the manufacture example 1 were filled in 5 K of white glass bottles, the stopper was sealed, and the package was obtained.

[Test Example 1]

After storing the package obtained in Example 1 and the comparative example 1 for 6 months at 40 degreeC-75% RH, it evaluated about the inside of the package whether it has an unpleasant odor derived from an aloe concentrate. Evaluation was carried out by six panelists using the following four criteria.

 1: Unpleasant smell remains strong.

 2: Slightly unpleasant smell.

 3: Almost no smell.

 4: No smell at all.

 The results are shown in Table 1.

In Example 1, all six panelists evaluated "4: No smell at all." In contrast, in Comparative Example 1, five panelists rated "1: unpleasant odors remain strong", and one panelist rated "2: slightly unpleasant odors", and "3: almost no smell" No panelist rated "or" 4: no smell at all ". That is, in Comparative Example 1, an unpleasant odor derived from an aloe concentrate was recognized by long-term storage at high temperature, but in Example 1, the unpleasant odor was deodorized by the inclusion of a desiccant. In addition, even if the gas inside the bottle of Comparative Example 1 was replaced and the odor was evaluated after a certain time, the same unpleasant odor was recognized. Therefore, the unpleasant odor derived from the aloe processed product was not only temporarily accumulated in the sealed bottle. It is thought to arise from solid preparations over time.

[Production Example 2]

The tablet was manufactured according to the terms of the Japanese Pharmacopoeia General Regulations "Tablets" by taking the following components and the amount (daily dose / 3 tablets).

Aloe Concentrate 375 mg

Pyridoxine hydrochloride 50 mg

Niacinamide 5 mg

Lactobacillus Powder 30 mg

Natto Powder 10 mg

Lactose Carb 655 mg

300 mg of crystalline cellulose

Hydroxypropylcellulose 30 mg

Light silicic anhydride 30 mg

15 mg magnesium stearate

[Manufacture example 3]

The tablet was manufactured according to the terms of the Japanese Pharmacopoeia General Regulations "Tablets" by taking the following ingredients and the amount (amount per day / 3 tablets).

Aloe Concentrate 750 mg

Nicotinamide 3 mg

Calcium Pantothenate 30 mg

Bifidus powder 60 mg

Glycolytic Powder 20 mg

Lactose Carb 810 mg

300 mg of crystalline cellulose

Hydroxypropylcellulose 40 mg

Hydrous Silicon Dioxide 110 mg

20 mg magnesium stearate

[Production Example 4]

The tablet was manufactured according to the terms of the Japanese Pharmacopoeia General Regulations "Tablets" by taking the following components and the amount (daily dose / 3 tablets).

Aloe Concentrate 190 mg

Thiamine Nitrate 25 mg

Calcium Pantothenate 20 mg

Butyric Acid Powder 90 mg

Lactobacillus Powder 50 mg

Lactose Carb 612 mg

200 mg crystalline cellulose

Hydroxypropylcellulose 40 mg

Hard silicic anhydride 26 mg

Magnesium Stearate 13 mg

[Examples 2 to 4]

Each 100 tablets of Production Examples 2 to 4 were each filled in a white glass bottle 5K, and further 1.25 g of a tablet silica gel (PW1805: Yamani Yakuhin Co., Ltd.) was added, and the stopper was sealed to seal the package of the present invention. Got.

Even after all these packages were stored for 6 months at 40 degreeC-75% RH, the unpleasant odor derived from aloe processing was not recognized.

Claims (3)

A method for deodorizing an aloe-derived odor, wherein the solid preparation containing the aloe processed product and the drying agent are stored in a closed system. A method for packaging a solid formulation, wherein the solid formulation containing the aloe processed product and the drying agent are stored in a closed system. The package packaged by the packaging method of Claim 2.