KR20100040389A - Cosmetic composition containing preservative substitutes - Google Patents

Abstract

PURPOSE: A cosmetic composition containing antiseptic substitute is provided to ensure antibacterial activity with high formulation stability. CONSTITUTION: A cosmetic composition contains 0.1-1.5 weight% of caprylic glycol, 0.1-1.5 weight% of ethylhexylglycerin, 0.01-10.0 weight% of rutaceae extract and residual amount of cosmetics. The rutaceae extract is isolated using water, hydrous and anhydrous alcohol of 1-4 carbon atoms, acetone, ethyl acetate, chloroform, or 1,3-butyleneglycol. The composition is used in the form of emulsion, cream, essence, gel, pack, cleansing cream, foam cleansing, foundation, or body wash.

Description

Cosmetic composition comprising a preservative substitute {{Cosmetic Composition Containing Preservative Substitutes}

Field of invention

The present invention relates to a cosmetic composition comprising a cosmetic preservative substitute. More specifically, the present invention does not include a component (designation designated ingredient) designated as a disinfectant and preservative in the conventional cosmetic method, and replaces preservatives caprylyl glycol, ethylhexylglycerine and sulfur white extract with antibacterial and antiseptic effect. It relates to a cosmetic composition containing as.

Background of the Invention

In general, the cosmetic composition is composed of various raw materials such as oils, surfactants, inorganic powders, organic water-soluble polymers, fragrances. These constituents are good nutrients for fungi and bacteria that facilitate the penetration and reproduction of microorganisms. In addition, there is a risk of secondary contamination due to repeated use, and because of the long period of use unlike food and pharmaceuticals, the addition of preservatives was essential. These preservatives are used for the purpose of preventing the change of the product by inhibiting the proliferation of microorganisms that are incorporated into cosmetics and contaminate cosmetics from the outside.

Preservatives currently used in cosmetics are paraoxybenzoic acid esters, phenoxyethanol, imidazolidinyl urea, DMDM hydantoin, benzalkonium chloride and the like.

However, the use of these preservatives can cause skin problems, and the American Dermatological Society also announced in 2002 that preservatives are the second leading cause of skin allergies.

Recently, as new additives such as proteins, gums, vitamins, and medicinal plants are added, the changes caused by the action of microorganisms are also diversified, which leads to an increase in the amount of preservatives added since the antiseptic function is weakened.

Of course, it is also possible to prepare a cosmetic composition without preservatives, but in this case, complex means such as aseptic manufacturing, limiting the amount of contents or the period of use, or specially manufacturing containers are necessary to secure the preservative function, and economic versatility. It may also lack.

In addition, many extracts having an antimicrobial effect have been studied, but the extract alone has the same effect as preservatives, and at the same time, there have been many limitations to secure skin safety and formulation stability. For example, grapefruit seed extract has a small amount of antiseptic effect but has a high irritation to the skin, which limits its use. The disadvantage is the low stability of the formulation. In addition, many extracts have been studied, but the amount of use is excessive, or there are many limitations such as discoloration or odor. Therefore, there is an urgent need for the development of a cosmetic composition having an antiseptic activity having sufficient preservative power without any side effects on the skin.

Thus, the present invention is to solve the problems of the prior art as described above, by mixing the composition having an antiseptic activity such as caprylyl glycol, ethexyl glycerine and sulfur white extract in the cosmetics, while showing sufficient antiseptic effect skin It is to develop a cosmetic composition that causes little irritation and excellent formulation stability.

An object of the present invention is to provide a cosmetic composition having excellent antibacterial and antiseptic properties without the addition of a preservative by mixing the composition having the antiseptic activity of caprylyl glycol, ethyl hexyl glycerin and sulfur white extract in the cosmetic composition.

Another object of the present invention is to provide a cosmetic composition that does not cause skin irritation while showing an antiseptic effect.

Still another object of the present invention is to provide a cosmetic composition having an antiseptic effect and excellent stability of a formulation without blending existing preservatives.

The above and other objects of the present invention can be achieved by the present invention described in detail below.

Summary of the Invention

The cosmetic composition according to the present invention comprises 97 to 99.7 wt% of the cosmetic and 0.1 to 1.5 wt% of caprylyl glycol having antiseptic activity; And 0.1 to 1.5% by weight of ethylhexylglycerol.

The caprylyl glycol and ethylhexylglycerine are characterized in that the composition is mixed in a ratio of 6: 1 to 1: 6. In addition, the cosmetic composition may further comprise 0.01 to 2.0% by weight of sulfur white extract.

The sulfur extract is (a) water, (b) anhydrous and hydrous lower alcohol having 1 to 4 carbon atoms, (c) acetone, (d) ethyl acetate, (e) chloroform and (f) 1,3-butylene glycol At least one extractant selected from the group consisting of 4 to 8 times the dry weight of the cedar is added at low temperature in the extractor.

The cosmetic composition comprises a formulation selected from the group consisting of lotion, emulsion, cream, essence, gel, pack, cleansing cream, foam cleansing, foundation, mascara, eye shadow, eyeliner, shampoo, rinse, and body wash. Have

Hereinafter, specific contents of the present invention will be described in detail below.

Detailed Description of the Invention

The present invention relates to a cosmetic composition having antiseptic activity, which does not contain the antiseptic or preservative ingredients specified in the existing cosmetic method added to cosmetics, has a preservative effect, does not cause irritation to the skin, and has excellent formulation stability. It is about.

The present invention provides a safe and harmless cosmetic composition by using caprylyl Glycol, Ethylhexylglycerin and Phellodendron amurense bark extract as a preservative for cosmetics instead of conventional preservatives.

In general, the Food and Drug Administration requires the legal content of sterilization and preservatives to be specified and labeled as labeling ingredients. In the present invention, in order to make a cosmetic composition that does not include such labeling ingredients, the antimicrobial activity of the various raw materials expected to have an antimicrobial effect used in cosmetics to confirm the effect of killing microorganisms, based on the results obtained therefrom Caprylyl glycol, ethylhexylglycerine, and sulfur white extract were selected. After applying them to cosmetics, the CTFA microbial test measures the killing effect on microorganisms such as bacteria, fungi and bacteria.

Raw materials having an antimicrobial activity used in the present invention are caprylyl glycol, ethylhexylglycerine, and sulfur white extract.

Caprylyl glycol used in the present invention serves as a moisturizer with an antimicrobial activity as an INCI Name Caprylyl Glycol, and usually exhibits sufficient antiseptic effect even when used alone as an emollient or significantly reduces the amount of chemical preservatives. Although it is a composition that can be used, it has been shown to adversely affect the stability of the formulation when used in large amounts.

Ethylhexylglycerin used in the present invention exhibits antibacterial properties as Ethylhexylglycerin INCI Name has antibacterial action and various skin control functions.

The caprylyl glycol and ethylhexylglycerin used as an antiseptic substitute in the present invention are chemically synthesized, and in the preferred embodiment of the present invention, caprylyl glycerine from drstraetmans and ethylhexylglycerine from Adeka are necessarily used. It is not limited to those manufactured by the manufacturer.

The Phellodendron amurense bark extract used in the present invention is obtained from Hwangbaekpi, the bark of the stems of the wild oyster, which is native to Korea, and a representative example of the baekbaek is Phellodendron amurense RUPRECHT. . His variants include var. Latifoliolatum NAKAI, var.Japonicum OHWI, P. insulare NAKAI, and P. molle NAKAI. , P. sachalinense Sarg.

Yellow and white skin contains about 1.5 to 4.5% of yellow or tan pigment material and several kinds of alkaloids. The main component of alkaloids is berberine. In addition, baekbaekpi contains palmin, magnoflorine, guanidine, jateorrizine, phellodendrine, candicine and menisperine. In addition, it is known that omikunone (obakunone), obakulactone and the like are contained. These ingredients have strong antibacterial action, blood pressure lowering action, central nerve suppression action, acetylcholine enhancement action and anti-inflammatory action and have been used for bone disease and jaundice in herbal or medicinal wood. It is also effective for typhoid fever, cholera, dry stomach, and intestinal tract, and their bark has been used for gastroenteritis, abdominal pain, jaundice, and the like as a high-density agent, a formal agent, and an anti-inflammatory astringent drug.

The sulfur extract in the present invention can be obtained through a method known in the art. Preferably (a) water, (b) anhydrous and hydrous lower alcohols (e.g. methanol, ethanol, propanol, butanol, etc.), (c) acetone, (d) ethyl acetate, (e) chloroform or (f) 1,3-butylene glycol or the like is used as an extraction solvent to obtain from Pyrophyllum japonica. Preferred extraction solvents are water, ethanol or methanol, more preferably a mixture of water and ethanol, most preferably 70% ethanol. Suitable amounts of the extraction solvent are 3 to 10 times, preferably 4 to 8 times and most preferably 6 times the dry weight of the cedar.

On the other hand, the extract of the present invention can be obtained not only the above-described extraction solvent, but also white-yellow extract having substantially the same effect using another extraction solvent.

The yellowish white extract according to the present invention may be prepared by a process comprising the following steps: (a) 3 to 10 times water, 1-4 anhydrous and hydrous lower alcohols, acetone, ethyl acetate, Adding at least one solvent selected from the group consisting of butyl acetate and 1,3 butylene glycol; (b) refluxing the solvent including the yellow-backwood of (a) and extracting by cold extraction for 24 to 72 hours or by heating for 4 to 6 hours; And (c) filtering and drying or lyophilizing the extracted components of (b).

According to an embodiment of the present invention, after washing, drying and crushing the yellow tree, 200 g of the yellow tree is placed in 1.2 L of 70% ethanol, cold extraction for 48 hours in an extractor and filtered through 300 mesh. It is then left to mature for 5 to 10 days, preferably 7 to 10 days, and then filtered with Whatman 5 filter paper. The filtrate is distilled under reduced pressure and dried to obtain a dry weight of 12.50 g.

In addition, the yellowish white extract of the present invention includes not only the extract by the extraction method, but also an extract that has undergone a conventional purification process. Examples include separation using an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity), and the like. It may also be prepared in powder form by additional processes such as distillation under reduced pressure, freeze drying or spray drying.

The antiseptic cosmetic composition according to the present invention is an antiseptic substitute having an antimicrobial action, 0.1 to 1.5% by weight of caprylyl glycol, 0.1 to 1.5% by weight of ethylhexylglycerine, and extra cosmetics based on the total weight of the cosmetic composition. It is made, including. The cosmetics include ingredients conventionally used in cosmetic compositions. The composition of the cosmetic may be appropriately selected according to the formulation by those skilled in the art, and the present invention may be applied irrespective of the composition of the cosmetic. When caprylyl glycol and ethylhexylglycerin are each used at less than 0.1% by weight, no antimicrobial effect, particularly antiseptic effect, can be expected, and when the content exceeds 1.5% by weight, skin irritation and formulation are not stable. Not desirable

Cosmetic composition having antiseptic activity according to the present invention is 0.1 to 1.5% by weight of caprylyl glycol, 0.1 to 1.5% by weight of ethylhexylglycerin, 0.01 to 10% by weight of white and white extract, and the amount based on the total weight of the cosmetic composition It may be made including a cosmetic. When the sulfur extract is more than 10% by weight, it causes skin irritation and the formulation is not stable, which is not preferable as a cosmetic composition. In one example of the present invention, the preferred content of sulfur white extract is 0.01 to 10.0% by weight, more preferably 0.01 to 2.0% by weight based on the total cosmetic composition.

Caprylyl glycol and ethylhexylglycerol contained in the cosmetic composition of the present invention is preferably mixed in a ratio of 6: 1 to 1: 6, more preferably in a ratio of 5: 1 to 1: 1. The composition is mixed, and most preferably, the composition is at a ratio of 3: 2.

In the case of preservatives, it is important to know the minimum amount to secure the antiseptic power since all of the preservatives are added when the minimum amount is added. This is because, in the case of a cosmetic composition, it is necessary to ensure safety while having an antiseptic power, because when the content of the preservative increases, the safety decreases.

In one example of the cosmetic composition according to the present invention comprises 0.2 to 0.7% by weight of the mixture of the caprylyl glycol and the ethylhexyl glycerin relative to the total weight of the cosmetic composition and 0.01 to 2.0% by weight of the sulfur white extract Can be done.

According to a preferred embodiment of the present invention, the mixed composition consisting of caprylyl glycol and ethylhexylglycerin and sulfur white extract may be blended into the cosmetic composition at 0.3% by weight and 0.5% by weight, respectively. According to another preferred embodiment of the present invention, when the caprylyl glycol and ethyl hexyl glycerine mixed composition and sulfur white extract is 0.5% by weight and 0.1% by weight, respectively, the skin irritation is the weakest, the effect as a preservative It can be used as a useful cosmetic composition showing little skin irritation.

The components included in the cosmetic composition of the present invention may further include an active ingredient capable of imparting a useful effect to the skin in addition to the caprylyl glycol, ethhexyl glycerine and sulfur white extract having antiseptic activity. Active ingredients that can impart useful effects to the skin include anti-aging ingredients, wrinkle improvement ingredients, whitening ingredients, moisturizing ingredients and antibacterial ingredients, and the like, and are not limited to specific ingredients.

In addition to the above components, it may also include components conventionally used in cosmetic compositions, and include conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, and carriers.

The compositions of the present invention can be prepared in any formulation commonly prepared in the art. For example, it may be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray, It is not limited to this. More specifically, the cosmetic composition of the present invention includes a basic cosmetic such as lotion, emulsion, cream, essence, gel, pack, cleansing cream and foam cleansing; Makeup cosmetics such as foundation, mascara, eyeshadow and eyeliner; Cosmetics for hair such as shampoo and rinse; Body cosmetics such as body wash; And it can be prepared in a formulation selected from the group consisting of functional cosmetics for the purpose of anti-aging, wrinkle improvement or whitening.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol, oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Qualitative cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide ether. Sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The invention can be better understood through the following examples, which are intended for purposes of illustration of the invention and are not intended to limit the scope of protection defined by the appended claims.

Example

Experimental Example 1 Antibacterial Activity of Caprylyl Glycol and Ethylhexylglycerine

To investigate the antimicrobial activity of caprylyl glycol and ethylhexylglycerin, methylparaben, propylparaben, phenoxyethanol, and chlorphenesin, caprylyl glycol and ethylhexylglycerine, which are used as preservatives The mixed composition was compared. The bacteria are against Escherichia coli ATCC 8739, Pseudomonas aeruginosa (ATCC9027) and Staphylococcus aureus (ATCC6538), and the fungus is antibacterial against C. albicans . The effect was measured.

A mixed composition of caprylyl glycol and ethylhexylglycerine was prepared by the following method.

Caprylyl glycol and ethexyl glycerine are preferably mixed in a ratio of 6: 1 to 1: 6, more preferably in a ratio of 5: 1 to 1: 1, and in this embodiment, The composition was mixed at a ratio of 3: 2.

As shown in Table 1, the cosmetic composition containing a mixed composition of caprylyl glycol and ethylhexylglycerin showed a similar or better antiseptic ability than conventional preservatives against bacteria and fungi.

Experimental Example 2: Antimicrobial Activity Test of Yellowish White Extract

In order to examine the antibacterial activity of the yellowish white extract, the composition of the yellowish white extract (10%) was compared with methylparaben, propylparaben, phenoxyethanol, and chlorphenesin using the conventional preservatives. Bacteria are resistant to Escherichia coli ATCC 8739, Pseudomonas aeruginosa (ATCC9027) and Staphylococcus aureus (ATCC6538), and the fungus is antibacterial against C. albicans . The effect was measured.

Sulfur extract was prepared by the following method.

The raw rhubarb is washed, dried and crushed into small pieces, 200 g of rhubarb is placed in 1.2 L of 70% ethanol, and extracted at low temperature for 48 hours in an extractor, followed by filtration at 300 mesh. After aging for 5 to 10 days, preferably 7 to 10 days, the resultant was filtered using Whatman No. 5 filter paper. The filtrate was distilled under reduced pressure and dried to obtain a dry weight of 12.50 g.

As shown in Table 2, the cosmetic composition containing only sulfur white extract required a higher inhibitory concentration than conventional preservatives for bacteria and fungi.

Experimental Example 3: Antimicrobial Activity of Caprylyl Glycol, Ethyl Hexyl Glycerin, and White and White Extract Mixture

A mixture of caprylyl glycol and ethylhexylglycerine and a mixture of sulfur white extract were carried out in the same manner as in Example 1 and 2, except that the mixing ratio was as shown in Table 3 below. The antimicrobial activity against bacteria and fungi was tested and the results are shown in Table 3. The concentration of the mixture of caprylyl glycol and ethylhexylglycerine was tested at a fixed concentration of 0.25%, the minimum concentration showing antiseptic activity in Experimental Example 1.

As shown in Table 3, the antibacterial activity of the sulfur white extract was concentration-dependent when the sulfur white extract was mixed with the mixed composition of caprylyl glycol and ethylhexylglycerin.

Experimental Example 4 Experiment of Antiseptic Effect in Cosmetics Containing a Mixture of Caprylyl Glycol, Ethyl Hexyl Glycerine and White and White Extract

In the Experimental Example 3, the following experiment was carried out for the case where the amount of sulfur white extract was minimally contained in the amount of the mixture composition of the same caprylyl glycol and ethylhexylglycerin.

First, Examples 1 and 2 of the skin lotion formulation were prepared according to the conventional cosmetic preparation method in the composition ratio of Table 4 below.

In addition, according to the conventional cosmetic preparation method in the composition ratio of Table 5, Examples 3 and 4 of the milk lotion formulations were prepared.

In addition, Examples 5 and 6 of the cream formulations were prepared according to the conventional cosmetic preparation method with the composition ratio of Table 6 below.

To confirm the antiseptic effect of Examples 1 to 6 prepared according to the present invention is shown in Table 7. The antiseptic effect was confirmed by the inoculation of microorganisms and tested for death. First, bacteria and fungi were inoculated into the cosmetic samples to confirm the degree of killing of microorganisms up to 1, 3, 7, 14, and 28 days. Strain used in the experiment is 1 × 10 ⁷ per the bacteria Escherichia coli (Escherichia coli), Pseudomonas Ke Rouge labor (Pseudomonas aeruginosa), Staphylococcus aureus (Staphylococcus aureus), and Pseudomonas Sepharose cyano (Pseudomonas cepacia) sample 1g The fungus (yeast, fungus) was inoculated with Candida albicans and Aspergilus niger to 1 × 10 ⁷ cells per gram of sample.

As shown in Table 7, the cosmetic composition prepared according to the present invention was confirmed to have an excellent antiseptic effect.

Experimental Example 5: Skin Primary Irritation Test

To determine the skin safety of the cosmetic composition prepared according to the present invention, a sample was prepared as shown in Table 8 below. The primary skin irritation test was to patch 30 samples of healthy adults in each arm 50 cm with patch (approximately 0.1 g) for 24 hours, then remove them, and then remove 1 It proceeded to read the skin condition change visually after 24 hours and after 24 hours. The experimental results are shown in Table 9 below.

As shown in Table 9, it can be seen that the degree of stimulation of the cosmetics prepared by mixing caprylyl glycol, ethylhexylglycerin and yellowish white extract showed a very low irritation compared to the cosmetic of Comparative Example 1 using a common preservative. have. In particular, the cosmetic composition of Example 8, in which a mixture of caprylyl glycol and ethylhexyl glycerin and a white and white extract were mixed at 0.2: 0.3%, has no skin irritation, and thus skin irritation safety than when the above components were used at other ratios. The improvement was found to be the best.

Experimental Example 6: Formulation Stability Test of Cosmetics Containing Caprylyl Glycol, Ethyl Hexyl Glycerin and Yellow White Extract

The stability according to the temperature change of the cosmetic formulation according to the present invention was tested. The cosmetic of Example 7 to 10 containing caprylyl glycol, ethylhexylglycerin and sulfur white extract as preservatives and the cosmetic composition of Comparative Example 1 containing methylparaben as an antiseptic without containing the above ingredients were opaque After storing for 1 week in a constant temperature bath maintained at 45 ℃ and 25 ℃ was compared to measure the degree of discoloration. In addition, the degree of discoloration was measured after storing for one week in a refrigerator completely kept in a opaque glass container at 4 ℃ and completely shaded.

The results are shown in Table 10 below. At this time, the degree of product discoloration was evaluated by classifying into six grades as follows.

As shown in Table 10, according to the present invention, the cosmetics of Examples 7 to 10 containing caprylyl glycol, ethylhexylglycerin, and yellowish white extract as preservatives are hardly discolored, and thus methylparaben is used as an existing preservative. It turns out that stability is excellent similarly to the cosmetics of the comparative example 1 which contained.

Instead of the conventional chemical preservatives added to cosmetics according to the present invention by mixing caprylyl glycol, ethylhexylglycerin and sulfur white extract in the cosmetic composition, excellent antimicrobial and antiseptic power can exhibit excellent effects as a preservative In addition, the invention has the effect of providing a safe cosmetic composition without causing skin irritation and excellent stability of the formulation.

Simple modifications and variations of the present invention can be readily used by those skilled in the art, and all such variations or modifications can be considered to be included within the scope of the present invention.

Claims (4)

Caprylyl glycol 0.1-1.5 wt%; 0.1-1.5 wt% of ethylhexylglycerin; 0.01-10.0 wt% of sulfur white extract; And a preservative substitute, characterized in that consisting of extra cosmetic. The cosmetic composition according to claim 1, wherein the content of the yellowish white extract is 0.01 to 2.0% by weight. The method according to claim 1, wherein the sulfur extract is (a) water, (b) anhydrous and hydrous lower alcohol having 1 to 4 carbon atoms, (c) acetone, (d) ethyl acetate, (e) chloroform and (f) 1, Cosmetic composition comprising a preservative substitute, characterized in that the extraction at low temperature in the extractor after adding at least one extraction solvent selected from the group consisting of 3-butylene glycol in a volume of 4 to 8 times the dry weight of the yellow wood. The cosmetic composition of claim 1, wherein the cosmetic composition comprises a lotion, emulsion, cream, essence, gel, pack, cleansing cream, foam cleansing, foundation, mascara, eye shadow, eyeliner, and body wash. Cosmetic composition comprising a preservative substitute, characterized in that it has a formulation selected from the group consisting of one.