KR20100036306A - 치료용 피라졸로나프티리딘 유도체 - Google Patents

치료용 피라졸로나프티리딘 유도체 Download PDF

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Publication number
KR20100036306A
KR20100036306A KR1020107000331A KR20107000331A KR20100036306A KR 20100036306 A KR20100036306 A KR 20100036306A KR 1020107000331 A KR1020107000331 A KR 1020107000331A KR 20107000331 A KR20107000331 A KR 20107000331A KR 20100036306 A KR20100036306 A KR 20100036306A
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KR
South Korea
Prior art keywords
alkyl
compound
aryl
animal
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020107000331A
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English (en)
Korean (ko)
Inventor
아란 피. 카프란
바르샤 굽타
얀 더블유.에프. 웨슬리
Original Assignee
헬리콘 테라퓨틱스 인코퍼레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 헬리콘 테라퓨틱스 인코퍼레이티드 filed Critical 헬리콘 테라퓨틱스 인코퍼레이티드
Publication of KR20100036306A publication Critical patent/KR20100036306A/ko
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020107000331A 2007-06-08 2008-06-06 치료용 피라졸로나프티리딘 유도체 Withdrawn KR20100036306A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94300007P 2007-06-08 2007-06-08
US60/943,000 2007-06-08

Publications (1)

Publication Number Publication Date
KR20100036306A true KR20100036306A (ko) 2010-04-07

Family

ID=40130166

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107000331A Withdrawn KR20100036306A (ko) 2007-06-08 2008-06-06 치료용 피라졸로나프티리딘 유도체

Country Status (12)

Country Link
US (2) US7858614B2 (https=)
EP (1) EP2166853B1 (https=)
JP (1) JP2010529145A (https=)
KR (1) KR20100036306A (https=)
CN (1) CN101754681A (https=)
AU (1) AU2008261803A1 (https=)
BR (1) BRPI0812369A2 (https=)
CA (1) CA2689934A1 (https=)
ES (1) ES2483728T3 (https=)
IL (1) IL202287A0 (https=)
MX (1) MX2009013197A (https=)
WO (1) WO2008154447A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008154442A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline urea derivatives
US9012470B2 (en) 2010-10-14 2015-04-21 Dart Neuroscience (Cayman) Ltd. Therapeutic 5,6,5-tricyclic analogs
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2017070481A1 (en) * 2015-10-23 2017-04-27 Harman International Industries, Incorporated Dual asymmetric compression driver
CN106810550A (zh) * 2017-01-10 2017-06-09 湖南华腾制药有限公司 一种萘啶衍生物的制备方法
US11485733B2 (en) 2017-06-30 2022-11-01 Bayer Animal Health Gmbh Azaquinoline derivatives
CN117430602A (zh) * 2023-09-26 2024-01-23 爱斯特（成都）生物制药股份有限公司 一种制备6-卤代-4-羟基[1,5]萘啶-3-甲酸酯及其衍生物的方法
CN117447469A (zh) * 2023-10-27 2024-01-26 爱斯特（成都）生物制药股份有限公司 一种melk抑制剂关键中间体的连续流合成方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204126A1 (de) * 1982-02-06 1983-08-11 Bayer Ag, 5090 Leverkusen Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4479955A (en) * 1983-01-10 1984-10-30 Ciba-Geigy Corporation Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators
US4814450A (en) 1984-07-09 1989-03-21 Ciba-Geigy Corporation Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives
JPS61112075A (ja) * 1984-11-05 1986-05-30 Shionogi & Co Ltd チエニルピラゾロキノリン誘導体
EP0214092A1 (en) 1985-08-08 1987-03-11 Ciba-Geigy Ag Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone
US4817450A (en) * 1987-11-30 1989-04-04 Spedco, Inc. Pressure/temperature test plug assembly
FR2695126B1 (fr) * 1992-08-27 1994-11-10 Sanofi Elf Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.
US5334595A (en) * 1992-10-23 1994-08-02 Sterling Winthrop Inc. Pyrazoloquinolones as anticancer agents
DK0760819T3 (da) * 1994-05-24 2000-10-09 Hoffmann La Roche Tricykliske dicarbonylderivater
GB9716344D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
GB9716347D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
GB9716345D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
TWI271406B (en) * 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
JP3896309B2 (ja) * 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
US7674906B2 (en) * 2002-12-16 2010-03-09 Active Biotech Ab Tetracyclic immunomodulatory compounds
TW200508233A (en) * 2003-05-29 2005-03-01 Millennium Pharm Inc Chk-1 inhibitors
US7544697B2 (en) * 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
CN1893943A (zh) * 2003-10-03 2007-01-10 3M创新有限公司 吡唑并吡啶和其类似物
JP2009507081A (ja) * 2005-09-07 2009-02-19 ブレインセルス，インコーポレイティド ＨＤａｃ阻害による神経発生の調整
WO2008154438A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline derivatives

Also Published As

Publication number Publication date
BRPI0812369A2 (pt) 2016-08-09
US7858614B2 (en) 2010-12-28
AU2008261803A1 (en) 2008-12-18
EP2166853A1 (en) 2010-03-31
CN101754681A (zh) 2010-06-23
EP2166853A4 (en) 2011-04-06
US20090005365A1 (en) 2009-01-01
ES2483728T3 (es) 2014-08-07
IL202287A0 (en) 2010-06-16
EP2166853B1 (en) 2014-05-28
MX2009013197A (es) 2010-04-27
CA2689934A1 (en) 2008-12-18
US20110065692A1 (en) 2011-03-17
WO2008154447A1 (en) 2008-12-18
HK1142774A1 (en) 2010-12-17
US8497262B2 (en) 2013-07-30
JP2010529145A (ja) 2010-08-26

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20100107

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid