CN101754681A - 治疗用吡唑并萘啶衍生物 - Google Patents

治疗用吡唑并萘啶衍生物 Download PDF

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Publication number
CN101754681A
CN101754681A CN200880025152A CN200880025152A CN101754681A CN 101754681 A CN101754681 A CN 101754681A CN 200880025152 A CN200880025152 A CN 200880025152A CN 200880025152 A CN200880025152 A CN 200880025152A CN 101754681 A CN101754681 A CN 101754681A
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CN
China
Prior art keywords
alkyl
compound
aryl
animal
gaba
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880025152A
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English (en)
Chinese (zh)
Inventor
艾伦·P·卡普兰
瓦沙·古普塔
扬·W·F·瓦斯利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helicon Therapeutics Inc
Original Assignee
Helicon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helicon Therapeutics Inc filed Critical Helicon Therapeutics Inc
Publication of CN101754681A publication Critical patent/CN101754681A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880025152A 2007-06-08 2008-06-06 治疗用吡唑并萘啶衍生物 Pending CN101754681A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94300007P 2007-06-08 2007-06-08
US60/943,000 2007-06-08
PCT/US2008/066211 WO2008154447A1 (en) 2007-06-08 2008-06-06 Therapeutic pyrazolonaphthyridine derivatives

Publications (1)

Publication Number Publication Date
CN101754681A true CN101754681A (zh) 2010-06-23

Family

ID=40130166

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880025152A Pending CN101754681A (zh) 2007-06-08 2008-06-06 治疗用吡唑并萘啶衍生物

Country Status (12)

Country Link
US (2) US7858614B2 (https=)
EP (1) EP2166853B1 (https=)
JP (1) JP2010529145A (https=)
KR (1) KR20100036306A (https=)
CN (1) CN101754681A (https=)
AU (1) AU2008261803A1 (https=)
BR (1) BRPI0812369A2 (https=)
CA (1) CA2689934A1 (https=)
ES (1) ES2483728T3 (https=)
IL (1) IL202287A0 (https=)
MX (1) MX2009013197A (https=)
WO (1) WO2008154447A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106810550A (zh) * 2017-01-10 2017-06-09 湖南华腾制药有限公司 一种萘啶衍生物的制备方法
CN117430602A (zh) * 2023-09-26 2024-01-23 爱斯特（成都）生物制药股份有限公司 一种制备6-卤代-4-羟基[1,5]萘啶-3-甲酸酯及其衍生物的方法
CN117447469A (zh) * 2023-10-27 2024-01-26 爱斯特（成都）生物制药股份有限公司 一种melk抑制剂关键中间体的连续流合成方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008154442A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline urea derivatives
US9012470B2 (en) 2010-10-14 2015-04-21 Dart Neuroscience (Cayman) Ltd. Therapeutic 5,6,5-tricyclic analogs
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2017070481A1 (en) * 2015-10-23 2017-04-27 Harman International Industries, Incorporated Dual asymmetric compression driver
US11485733B2 (en) 2017-06-30 2022-11-01 Bayer Animal Health Gmbh Azaquinoline derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004159A1 (en) * 1999-12-13 2005-01-06 Eisai Co., Ltd. Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it
CN1893943A (zh) * 2003-10-03 2007-01-10 3M创新有限公司 吡唑并吡啶和其类似物

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DE3204126A1 (de) * 1982-02-06 1983-08-11 Bayer Ag, 5090 Leverkusen Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4479955A (en) * 1983-01-10 1984-10-30 Ciba-Geigy Corporation Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators
US4814450A (en) 1984-07-09 1989-03-21 Ciba-Geigy Corporation Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives
JPS61112075A (ja) * 1984-11-05 1986-05-30 Shionogi & Co Ltd チエニルピラゾロキノリン誘導体
EP0214092A1 (en) 1985-08-08 1987-03-11 Ciba-Geigy Ag Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone
US4817450A (en) * 1987-11-30 1989-04-04 Spedco, Inc. Pressure/temperature test plug assembly
FR2695126B1 (fr) * 1992-08-27 1994-11-10 Sanofi Elf Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.
US5334595A (en) * 1992-10-23 1994-08-02 Sterling Winthrop Inc. Pyrazoloquinolones as anticancer agents
DK0760819T3 (da) * 1994-05-24 2000-10-09 Hoffmann La Roche Tricykliske dicarbonylderivater
GB9716344D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
GB9716347D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
GB9716345D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
JP3896309B2 (ja) * 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
US7674906B2 (en) * 2002-12-16 2010-03-09 Active Biotech Ab Tetracyclic immunomodulatory compounds
TW200508233A (en) * 2003-05-29 2005-03-01 Millennium Pharm Inc Chk-1 inhibitors
US7544697B2 (en) * 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
JP2009507081A (ja) * 2005-09-07 2009-02-19 ブレインセルス，インコーポレイティド ＨＤａｃ阻害による神経発生の調整
WO2008154438A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004159A1 (en) * 1999-12-13 2005-01-06 Eisai Co., Ltd. Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it
CN1893943A (zh) * 2003-10-03 2007-01-10 3M创新有限公司 吡唑并吡啶和其类似物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106810550A (zh) * 2017-01-10 2017-06-09 湖南华腾制药有限公司 一种萘啶衍生物的制备方法
CN117430602A (zh) * 2023-09-26 2024-01-23 爱斯特（成都）生物制药股份有限公司 一种制备6-卤代-4-羟基[1,5]萘啶-3-甲酸酯及其衍生物的方法
CN117447469A (zh) * 2023-10-27 2024-01-26 爱斯特（成都）生物制药股份有限公司 一种melk抑制剂关键中间体的连续流合成方法

Also Published As

Publication number Publication date
BRPI0812369A2 (pt) 2016-08-09
US7858614B2 (en) 2010-12-28
KR20100036306A (ko) 2010-04-07
AU2008261803A1 (en) 2008-12-18
EP2166853A1 (en) 2010-03-31
EP2166853A4 (en) 2011-04-06
US20090005365A1 (en) 2009-01-01
ES2483728T3 (es) 2014-08-07
IL202287A0 (en) 2010-06-16
EP2166853B1 (en) 2014-05-28
MX2009013197A (es) 2010-04-27
CA2689934A1 (en) 2008-12-18
US20110065692A1 (en) 2011-03-17
WO2008154447A1 (en) 2008-12-18
HK1142774A1 (en) 2010-12-17
US8497262B2 (en) 2013-07-30
JP2010529145A (ja) 2010-08-26

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