KR20100018237A - Biomarkers for identification of exposure to phenanthrene and the method of identification using the same - Google Patents

Abstract

PURPOSE: A biomarker for confirming phenanthrene exposure is provided to monitor and determine phenanthrene pollution and to find a toxicity mechanism. CONSTITUTION: A biomarker for confirming phenanthrene contains a gene of which an expression is increased or decreased due to exposure to phenanthrene. A DNA microarray chip for confirming phenanthrene exposure contains oligotide having an entire or partial gene sequence or its complementary oligonuecleotide. A method for detecting the biomarker for confirming phenanthrene exposure comprises: a step of isolating RNA from a test person's somatic cells as an experimental group and normal somatic cells as a control group; a step of synthesizing cDNA of the experimental group and control group and labeling with different fluorescences; a step of hybridizing the labeled cDNA on a microarray chip; a step of analyzing DNA microarray chip; and a step of comparing expression level between control group and experimental group.

Description

Biomarkers for identifying phenanthrene exposure and identification method using the same {Biomarkers for identification of exposure to phenanthrene and the method of identification using the same}

The present invention relates to a biomarker for confirming exposure to phenanthrene and a method of identifying the same, and more particularly, to a biomarker in which gene expression is increased or decreased by phenanthrene, which is one of polycyclic aromatic hydrocarbons, and It relates to a method for checking the exposure to phenanthrene using the same.

Phenanthrene, one of the polycyclic aromatic hydrocarbons, is a glossy, blue, fluorescent, colorless plate-like crystal with a structure in which three benzene rings are condensed with each other, and are related to anthracene and isomers. . It was discovered in coal tar in 1872 by R. Pitich (Germany) and is contained in anthracene oil, mainly from coal tar, separated by precision distillation. When phenanthrene is oxidized to chromic acid, phenanthrene is produced, and when it is reduced, it becomes a hydrogenated compound in each step. Phenanthrene has been used as a synthetic raw material for dyes, plastics, insecticides, and pharmaceuticals, but is not manufactured or used for commercial purposes. It is mainly used for organic synthesis or chemical research.

In terms of the exposure level of phenanthrene in the environment, 1.2 ppb of phenanthrene was detected in the molten iron in a survey of major facilities expected to be released in the research on the distribution of aromatic hydrocarbons (PAHs) in industrial flue gas. Phenanthrene was also detected in the study (Environmental Research Institute, 1996). In addition, the concentration of PAH in the urban atmosphere of Korea was 0.31 ng / m ³ in Seoul residential area and 0.36 ng / m ³ in Taepyeong-dong, Daejeon (Ministry of Environment, 1997). International studies have shown that phenanthrene was found to be 0.4 ng / m ³ (1974) in New York, 100 ng / m ^{3 (} 1977-1978) in Osaka, Japan, and 28 ng in Paris, France. / m ³ (1981-1982) (Edoardo, The Science of the Total Environment , 116: 119-135, 1992).

Metabolism of phenanthrene is through epoxidation and phenanthrene-9,10-oxide and phenanthrene-1,2-diol-3,4-epoxide. 1,2-diol-3,4-epoxide). Phenanthrene is sensitive to the skin and has human health hazards such as dermatitis, bronchitis, cough, dyspnea, bronchial tumors, and kidney tumors. ) Are classified as non-carcinogenic substances (chemicals that cannot be classified as carcinogenic to humans).

Although some studies on the degree of carcinogenicity and gene expression of polyaromatic hydrocarbons have been reported, they are almost limited to studies on Benzo [a] pyrene, which is known as a representative polycyclic aromatic hydrocarbons. Despite the possibility of phenanthrene carcinogenesis in humans, there is not enough risk assessment data in humans, and the detection method for exposure is also known as Gas Chromatography-Mass Spectrometer (GC-MS) or High Performance Liquid Chromatography (HPLC). It is limited to the classical method. Quantification is possible using GC-MS or HPLC methods, but appropriate conditions for analysis are required and expensive equipment is required. Therefore, faster and easier screening methods, such as real-time reverse transcript polymerase chain reaction (PCR) or DNA microarray chips using primers, can be used to detect toxic effects in humans through rapid risk assessment. It is an important task to identify and utilize the molecular indicators that can be used to implement appropriate measures and management for phenanthrene exposure.

Several genome sequencing projects, including six mammals and 292 microbes, have been completed and reported to the National Center for Biotechnology Information (NCBI). Genome-wide expression studies are being conducted to study the function of genes based on the vast amount of data obtained. DNA microarray analysis is performed to analyze the expression of thousands of genes in one experiment (Schena, M., et al. , Proc . Natl . Acad . Sci . USA) . 93: 10614-10619, 1996).

Microarrays integrate cDNA (complementary DNA) or sets of oligonucleotides 20 to 25 base pairs in length on glass. cDNA microarrays are produced by labs in schools or companies such as Agilent, Genomic Solutions, etc., by mechanically immobilizing cDNA collections on chips or by using ink jetting (Sellheyer K. et. al., J. Am). . Acad Dermatol 51:.. 681-692 , 2004). Oligonucleotide microarrays are made by Affymetrix by direct synthesis on a chip using photolithography, and Agillent et al. Are produced by immobilizing synthesized oligonucleotides (Sellheyer, K.). et. al., J. Am . Acad . Dermatol . 51: 681-692, 2004).

To analyze gene expression, RNA is obtained from samples such as tissues and hybridized with oligonucleotides in DNA microarrays. The resulting RNA is labeled with fluorescence or isotope and converted to cDNA. Oligo microarrays are mainly labeled with two different fluorescences (eg, Cye3 and Cye5) to perform hybridization reactions on the same chip at the same time. . Gene expression is determined by the ratio of the two fluorescence intensities (Somasundaram, K. et al. , Genomics Proteomics I: 1-10, 2002).

In combination with recent research on toxic genomics (Toxicogenomics), an advanced technique using DNA macroarray technology, high-throughput expression in specific tissues or cell lines by all chemicals, including pharmaceuticals and new drug candidates, as well as representative environmental pollutants Analysis and quantitative analysis of expression patterns of genes are now possible. Accordingly, by analyzing the frequency of expression of specific genes in specific cells, it is possible to discover genes related to adverse effects of drugs and harmful effects of environmental pollutants, and through this, molecules according to the harmful effects of environmental pollutants, drugs, and side effects. It will be possible to understand the mechanisms and further search and identify substances that cause toxicity and side effects.

Accordingly, the present inventors have discovered and analyzed gene expression profiles of phenanthrene in HepG2 cell line, which is human liver cancer cells, using oligomicroarrays in which 44,000 human genes were accumulated, thereby discovering genes overexpressed or underexpressed by phenanthrene. The present invention was completed by establishing a biomarker capable of detecting phenanthrene and an exposure method using the same by confirming expression of the genes by real-time RT-PCR method.

It is an object of the present invention to provide a biomarker that is overexpressed or underexpressed by exposure of phenanthrene and a method for identifying exposure to phenanthrene using the biomarker.

In order to achieve the above object, the present invention provides a biomarker for confirming the exposure to phenanthrene, characterized in that the expression changes by the exposure of phenanthrene (phenanthrene).

In addition, the present invention provides a DNA microarray chip for confirming whether phenanthrene is exposed to an oligonucleotide including all or a part of the biomarker gene sequence or its complementary oligonucleotide.

In addition, the present invention provides a method for detecting the biomarker to determine whether the biomarker is exposed to phenanthrene.

In addition, the present invention provides a search kit for confirming exposure to phenanthrene.

The biomarker for confirming the exposure to phenanthrene of the present invention and a method of confirming the same using the same are useful for determining phenanthrene's monitoring and risk by using reaction genes selected through DNA microarray chips as biomarkers. It can be used as a tool to identify the mechanism of toxic effects caused by.

Hereinafter, the present invention will be described in detail.

The present invention provides a biomarker for confirming exposure to phenanthrene, which is characterized by causing a change in expression by exposure of phenanthrene.

The biomarker is a gene whose expression is increased or decreased more than two times, and includes MAPKinase Signaling Pathway, MAPKKK cascade, apoptosis, Mitotic cell cycle, and cell cycle. cell cycle, cell differentiation, cell motility, cytoskeleton, morphogenesis, response to DNA damage stimulus, response to chemical stimulation chemical stimulus, Response to external stimulus, Response to stress, immune response, Metabolism of xenobiotics by cytochrome p450, alcohol metabolism (Alcohol metabolism), lipid metabolism, phosphate metabolism (Phosphate metabolism), DNA metabolism (DNA metabolism), metal binding or transport (transport) related genes All.

The present invention provides a biomarker which is selected from the group consisting of:

Gene accession number (GeneBank accession No. ) NM_004420 (DUSP8, Dual specificity phosphatase 8), gene accession number (GeneBank accession No. ) L11329 (DUSP2, Dual specificity phosphatase 2), gene accession number (GeneBank accession No. ) BC094766 (PKN1, Protein kinase N1), gene accession number (GeneBank accession No. ) AY247738 (TRIB3, Tribbles homolog 3 (Drosophila)), gene accession number (GeneBank accession No. ) AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), Gene Accession No. ) AB208849 (SHC1, Src homology 2 domain containing (SHC) transforming protein 1), gene accession number (GeneBank accession No. ) X02812 (TGFB1, Transforming growth factor, beta 1 (Camurati-Engelmann disease)), Gene Accession No. ) NM_198951 (TGM2, Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)), gene registration number (GeneBank accession No. NM_147780 (CTSB, Cathepsin B), gene accession number (GeneBank accession No. NM_078467 (CDKN1A, Cyclin-dependent kinase inhibitor 1A (p21, Cip1)), gene accession number (GeneBank accession No. NM_033027 (AXUD1, AXIN1 up-regulated 1), gene accession number (GeneBank accession No. NM_032797 (AMID, Apoptosis-inducing factor (AIF) -like mitochondrion-associated inducer of death), GeneBank accession No. ) NM_021960 (MCL1, Myeloid cell leukemia sequence 1 (BCL2-related)), gene registration number (GeneBank accession No. ) NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), gene accession number (GeneBank accession No. ) NM_016222 (DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41), gene accession number (GeneBank accession No. ) NM_013246 (CLC, Cardiotrophin-like cytokine factor 1), gene accession number (GeneBank accession No. ) NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), gene registration number (GeneBank accession No. ) NM_004281 (BAG3, BCL2-associated athanogene 3), gene accession number (GeneBank accession No. ) NM_003897 (IER3, Immediate early response 3), Gene accession number (GeneBank accession No. ) NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), gene accession number (GeneBank accession No. ) NM_003639 (IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No. ) NM_003311 (PHLDA2, Pleckstrin homology-like domain, family A, member 2), gene accession number (GeneBank accession No. ) NM_002737 (PRKCA, Protein Kinase C, alpha), Gene Accession Number (GeneBank accession No. NM_002648 (PIM1, Pim-1 oncogene), gene accession number (GeneBank accession No. NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), gene accession number (GeneBank accession No. ) NM_002305 (LGALS1, Lectin, galactoside-binding, soluble, 1 (galectin 1)), gene accession number (GeneBank accession No. ) NM_001013398 (IGFBP3, Insulin-like growth factor binding protein 3), gene registration number (GeneBank accession No. ) BX640923 (MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)), gene accession number (GeneBank accession No. ) BX537586 (STK17A, Serine / threonine kinase 17a (apoptosis-inducing)), gene accession number (GeneBank accession No. ) BG284742 (P8, P8 protein (candidate of metastasis 1)), gene accession number (GeneBank accession No. ) BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), gene accession number (GeneBank accession No. ) BC027949 (P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), gene accession number (GeneBank accession No. ) BC006365 (PSEN2, Presenilin 2 (Alzheimer disease 4)), gene accession number (GeneBank accession No. ) AY869712 (PPP1R13L, Protein phosphatase 1, regulatory (inhibitor) subunit 13 like), Gene Accession No. ) AY028896 (CARD10, Caspase recruitment domain family, member 10), gene accession number (GeneBank accession No. ) AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), gene accession number (GeneBank accession No. ) AK092872 (ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), gene registration number (GeneBank accession No. ) AK092808 (RRAGC, Ras-related GTP binding C), gene accession number (GeneBank accession No. ) AJ001898 (GDNF, Glial cell derived neurotrophic factor), gene accession number (GeneBank accession No. ) AF220656 (PHLDA1, Pleckstrin homology-like domain, family A, member 1), gene accession number (GeneBank accession No. AF055634 (UNC5C, Unc-5 homolog C (C.  elegans), GeneBank accession No. ) AB209485 (Vescular endothelial growth factor), gene accession number (GeneBank accession No. ) AB096256 (UNC5B, Unc-5 homolog B (C.  elegans), GeneBank accession No. ) AB007960 (SH3GLB1, SH3-domain GRB2-like endophilin B1), gene accession number (GeneBank accession No. ) X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), Gene accession number (GeneBank accession No. ) S62138 (DDIT3, DNA-damage-inducible transcript 3), gene accession number (GeneBank accession No. NM_078487 (CDKN2B, Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)), gene accession number (GeneBank accession No. ) NM_012127 (CIZ1, CDKN1A interacting zinc finger protein 1), gene accession number (GeneBank accession No. ) NM_005883 (APC2, Adenomatosis polyposis coli 2), gene accession number (GeneBank accession No. ) NM_004196 (CDKL1, Cyclin-dependent kinase-like 1 (CDC2-related kinase)), gene accession number (GeneBank accession No. ) NM_003236 (TGFA, Transforming growth factor, alpha), gene registration number (GeneBank accession No. ) NM_001261 (CDK9, Cyclin-dependent kinase 9 (CDC2-related kinase)), gene accession number (GeneBank accession No. ) NM_001007271 (DUSP13, Dual specificity phosphatase 13), gene accession number (GeneBank accession No. ) CR749511 (PARC, P53-associated parkin-like cytoplasmic protein), gene registration number (GeneBank accession No. CR623038 (ID2, Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), gene accession number (GeneBank accession No. CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No. ) BF965144 (IFITM1, Interferon induced transmembrane protein 1 (9-27)), gene accession number (GeneBank accession No. ) AK127679 (DUSP1, Dual specificity phosphatase 1), gene accession number (GeneBank accession No. ) AK096276 (CCND3, Cyclin D3), gene accession number (GeneBank accession No. ) AB209586 (MAPK13, Mitogen-activated protein kinase 13), gene accession number (GeneBank accession No. ) AB209465 (PCTK1, PCTAIRE protein kinase 1), gene accession number (GeneBank accession No. ) Z19588 (SKIL, SKI-like), gene accession number (GeneBank accession No. NM_020429 (SMURF1, SMAD specific E3 ubiquitin protein ligase 1), gene accession number (GeneBank accession No. ) NM_014767 (SPOCK2, Sparc / osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), Gene Accession No. ) NM_005979 (S100A13, S100 calcium binding protein A13), gene registration number (GeneBank accession No. NM_005187 (CBFA2T3, Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), gene accession number (GeneBank accession No. ) NM_004364 (CEBPA, CCAAT / enhancer binding protein (C / EBP), alpha), gene registration number (GeneBank accession No. ) NM_001769 (CD9, CD9 antigen (p24)), gene accession number (GeneBank accession No. ) NM_001718 (BMP6, Bone morphogenetic protein 6), gene accession number (GeneBank accession No. ) NM_000641 (IL11, Interleukin 11), gene accession number (GeneBank accession No. ) BX647459 (SERPINE2, Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2), gene registration number (GeneBank accession No. ) BQ066037 (RPS19, Ribosomal protein S19), gene accession number (GeneBank accession No. ) BE791300 (EDF1, Endothelial differentiation-related factor 1), Gene accession number (GeneBank accession No. ) BC038504 (SNF1LK, SNF1-like kinase), gene accession number (GeneBank accession No. ) AL832287 (ZAP70, Zeta-chain (TCR) associated protein kinase 70kDa), gene accession number (GeneBank accession No. ) AK125742 (PCGF1, Polycomb group ring finger 1), gene accession number (GeneBank accession No. ) AK124709 (NDRG1, N-myc downstream regulated gene 1), gene accession number (GeneBank accession No. ) AB011157 (PTDSR, Phosphatidylserine receptor), Gene Accession No. NM_013255 (MKLN1, Muskelin 1, intracellular mediator containing kelch motifs), gene accession number (GeneBank accession No. ) NM_006572 (GNA13, Guanine nucleotide binding protein (G protein), alpha 13), gene registration number (GeneBank accession No. NM_002211 (ITGB1, Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)), gene accession number (GeneBank accession No. ) CR601067 (PLAUR, Plasminogen activator, urokinase receptor), gene accession number (GeneBank accession No. ) BC050456 (THBS4, Thrombospondin 4), gene registration number (GeneBank accession No. ) AK027389 (CXCL16, Chemokine (C-X-C motif) ligand 16), gene accession number (GeneBank accession No. ) AJ132099 (VNN1, Vanin 1), gene accession number (GeneBank accession No. ) XM_371354 (FLJ10157, Hypothetical protein FLJ10157), gene accession number (GeneBank accession No. ) XM_208313 (TPM3, Similar to tropomyosin 4), gene accession number (GeneBank accession No. XM_208270 (ACR, Acrosin-like protease), gene accession number (GeneBank accession No. ) NM_203353 (PDLIM7, PDZ and LIM domain 7 (enigma)), gene accession number (GeneBank accession No. ) NM_201382 (PLEC1, Plectin 1, intermediate filament binding protein 500kDa), gene registration number (GeneBank accession No. ) NM_182961 (SYNE1, Spectrin repeat containing, nuclear envelope 1), gene accession number (GeneBank accession No. ) NM_181826 (NF2, Neurofibromin 2 (bilateral acoustic neuroma)), gene accession number (GeneBank accession No. NM_172069 (PLEKHH2, Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2), gene accession number (GeneBank accession No. ) NM_022648 (TNS, Tensin 1), gene accession number (GeneBank accession No. NM_017556 (FBLP-1, Filamin binding LIM protein 1), gene accession number (GeneBank accession No. NM_016081 (KIAA0992, Palladin, cytoskeletal associated protein), gene accession number (GeneBank accession No. ) NM_006617 (NES, Nestin), gene accession number (GeneBank accession No. ) NM_006262 (PRPH, Peripherin), gene accession number (GeneBank accession No. NM_005100 (AKAP12, A kinase (PRKA) anchor protein (gravin) 12), gene registration number (GeneBank accession No. NM_004368 (CNN2, Calponin 2), gene accession number (GeneBank accession No. ) NM_003388 (CYLN2, Cytoplasmic linker 2), gene accession number (GeneBank accession No. ) NM_003370 (VASP, Vasodilator-stimulated phosphoprotein), gene accession number (GeneBank accession No. ) NM_003128 (SPTBN1, Spectrin, beta, non-erythrocytic 1), gene accession number (GeneBank accession No. ) NM_002705 (PPL, Periplakin), gene accession number (GeneBank accession No. ) NM_002475 (MLC1SA, Myosin light chain 1 slow a), Gene accession number (GeneBank accession No. ) NM_002018 (FLII, Flightless I homolog (Drosophila)), Gene Accession Number (GeneBank accession No. ) NM_001465 (FYB, FYN binding protein (FYB-120 / 130)), gene registration number (GeneBank accession No. NM_001069 (TUBB2, Tubulin, beta 2A), gene accession number (GeneBank accession No. ) CR625172 (MGC8685, Tubulin, beta 2B), gene accession number (GeneBank accession No. CR616919 (KRT18, Keratin 18), gene accession number (GeneBank accession No. ) CR606241 (ACTG1, Actin, gamma 1), gene accession number (GeneBank accession No. ) CB240572 (MYH11, Myosin, heavy polypeptide 11, smooth muscle), gene accession number (GeneBank accession No. ) BX648253 (PTPN3, Protein tyrosine phosphatase, non-receptor type 3), Gene accession number (GeneBank accession No. ) BX648190 (WDR1, WD repeat domain 1), Gene accession number (GeneBank accession No. ) BX641076 (ACTN1, Actinin, alpha 1), gene accession number (GeneBank accession No. ) BX537978 (EPB41L1, Erythrocyte membrane protein band 4. 1-like 1), gene accession number (GeneBank accession No. ) BG121847 (NUDC, Nuclear distribution gene C homolog (A.  nidulans)), and GeneBank accession No. ) BC068013 (MYO1C, Myosin IC), gene accession number (GeneBank accession No. ) BC065499 (MAST2, Microtubule associated serine / threonine kinase 2), gene accession number (GeneBank accession No. ) BC051890 (TUBG2, Tubulin, gamma 2), gene accession number (GeneBank accession No. ) BC041874 (MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), gene accession number (GeneBank accession No. ) BC012597 (ACTA1, Actin, alpha 1, skeletal muscle), gene accession number (GeneBank accession No. ) AY484427 (KIF17, Kinesin family member 17), gene accession number (GeneBank accession No. ) AK130546 (STOML2, Stomatin (EPB72) -like 2), Gene accession number (GeneBank accession No. ) AK124711 (CORO2B, Coronin, actin binding protein, 2B), gene accession number (GeneBank accession No. ) AK123974 (MYL5, Myosin, light polypeptide 5, regulatory), gene accession number (GeneBank accession No. ) AK092792 (LOC389833, Similar to hypothetical protein MGC27019), gene accession number (GeneBank accession No. ) AK026518 (MYOHD1, Myosin head domain containing 1), gene accession number (GeneBank accession No. ) AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), gene accession number (GeneBank accession No. ) AF085886 (FLJ46675, Ribosomal protein L29 pseudogene 2), gene accession number (GeneBank accession No. ) AB209997 (MYO9B, Myosin IXB), gene accession number (GeneBank accession No. Y12692 (WNT11, Wingless-type MMTV integration site family, member 11), gene accession number (GeneBank accession No. ) Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), gene accession number (GeneBank accession No. X17033 (ITGA2, Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)), gene accession number (GeneBank accession No. ) U41763 (CLTCL1, Clathrin, heavy polypeptide-like 1), gene accession number (GeneBank accession No. NM_153609 (TMPRSS6, Transmembrane protease, serine 6), gene accession number (GeneBank accession No. ) NM_031483 (ITCH, Itchy homolog E3 ubiquitin protein ligase (mouse)), gene accession number (GeneBank accession No. ) NM_024342 (GRLF1, Glucocorticoid receptor DNA binding factor 1), gene accession number (GeneBank accession No. NM_017555 (EGLN2, Egl nine homolog 2 (C.  elegans), GeneBank accession No. NM_016569 (TBX3, T-box 3 (ulnar mammary syndrome)), gene accession number (GeneBank accession No. NM_004148 (NINJ1, Ninjurin 1), gene accession number (GeneBank accession No. ) NM_003377 (VEGFB, Vascular endothelial growth factor B), gene accession number (GeneBank accession No. ) NM_001983 (ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)), GeneBank accession No. ) NM_001552 (IGFBP4, Insulin-like growth factor binding protein 4), gene registration number (GeneBank accession No. ) NM_001430 (EPAS1, Endothelial PAS domain protein 1), Gene accession number (GeneBank accession No. NM_001300 (KLF6, Kruppel-like factor 6), gene accession number (GeneBank accession No. ) NM_001012661 (SLC3A2, Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), gene accession number (GeneBank accession No. NM_000596 (IGFBP1, Insulin-like growth factor binding protein 1), gene registration number (GeneBank accession No. ) NM_000474 (TWIST1, Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)), Gene Accession No. ) BX649103 (ChGn, Chondroitin beta1,4 N-acetylgalactosaminyltransferase), Gene Accession No. ) BM913048 (TIMP1, TIMP metallopeptidase inhibitor 1), gene accession number (GeneBank accession No. ) BM904612 (S100A6, S100 calcium binding protein A6 (calcyclin)), gene accession number (GeneBank accession No. ) BM556279 (EMP3, Epithelial membrane protein 3), gene accession number (GeneBank accession No. ) BC015041 (VAT1, Family with sequence similarity 82, member C), gene accession number (GeneBank accession No. ) AY258066 (OKL38, Pregnancy-induced growth inhibitor), gene accession number (GeneBank accession No. ) AK126729 (NDRG4, NDRG family member 4), gene accession number (GeneBank accession No. ) AK090459 (NFE2L1, Nuclear factor (erythroid-derived 2) -like 1), gene accession number (GeneBank accession No. ) AK074163 (ROBO4, Roundabout homolog 4, magic roundabout (Drosophila)), Gene accession number (GeneBank accession No. ) AK024680 (FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), gene accession number (GeneBank accession No. ) AF176422 (HEY1, Hairy / enhancer-of-split related with YRPW motif 1), gene accession number (GeneBank accession No. ) AF003837 (JAG1, Jagged 1 (Alagille syndrome)), gene accession number (GeneBank accession No. ) AB209322 (SEMA3B, Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B), GeneBank accession No. ) AB011150 (NRXN1, Neurexin 1), gene accession number (GeneBank accession No. ) NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)), gene accession number (GeneBank accession No. NM_052999 (CKLFSF1, CKLF-like MARVEL transmembrane domain containing 1), gene accession number (GeneBank accession No. NM_006644 (HSPH1, Heat shock 105kDa / 110kDa protein 1), gene registration number (GeneBank accession No. NM_005438 (FOSL1, FOS-like antigen 1), gene accession number (GeneBank accession No. ) NM_004996 (ABCC1, ATP-binding cassette, sub-family C (CFTR / MRP), member 1), gene accession number (GeneBank accession No. ) NM_002658 (PLAU, Plasminogen activator, urokinase), gene accession number (GeneBank accession No. ) NM_001353 (AKR1C1, Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha) -hydroxysteroid dehydrogenase)), gene accession number (GeneBank accession No. ) H18681 (C20orf139, Sulfiredoxin 1 homolog (S.  cerevisiae)), gene accession number (GeneBank accession No. ) DR004094 (HAMP, Hepcidin antimicrobial peptide), gene accession number (GeneBank accession No. ) BC082272 (KCNMB3, Potassium large conductance calcium-activated channel, subfamily M beta member 3), Gene Accession No. ) BC040494 (DNAJB2, DnaJ (Hsp40) homolog, subfamily B, member 2), gene registration number (GeneBank accession No. ) BC018064 (ATF6, Activating transcription factor 6), gene accession number (GeneBank accession No. ) BC006523 (SGK2, Serum / glucocorticoid regulated kinase 2), gene registration number (GeneBank accession No. ) AK090482 (CXCL12, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)), gene accession number (GeneBank accession No. ) AF219946 (TULP4, Tubby like protein 4), gene accession number (GeneBank accession No. ) AB209112 (SLC2A8, Solute carrier family 2, (facilitated glucose transporter) member 8), gene accession number (GeneBank accession No. ) NM_005242 (F2RL1, Coagulation factor II (thrombin) receptor-like 1), gene accession number (GeneBank accession No. ) NM_001002029 (C4A, Complement component 4B, telomeric), Gene accession number (GeneBank accession No. ) NM_000539 (RHO, Rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)), gene accession number (GeneBank accession No. ) BX649164 (PAI, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), gene registration number (GeneBank accession No. ) BM918324 (LY96, Lymphocyte antigen 96), gene accession number (GeneBank accession No. ) AB209647 (NCF2, Neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2)), gene accession number (GeneBank accession No. ) NM_152221 (CSNK1E, Casein kinase 1, epsilon), Gene accession number (GeneBank accession No. ) NM_017999 (RNF31, Ring finger protein 31), gene accession number (GeneBank accession No. ) NM_016819 (OGG1, 8-oxoguanine DNA glycosylase), Gene Accession No. ) NM_016816 (OAS1, 2 ', 5'-oligoadenylate synthetase 1, 40 / 46kDa), Gene Accession No. NM_012235 (SCAP, SREBP cleavage-activating protein), gene accession number (GeneBank accession No. ) NM_006384 (CIB1, Calcium and integrin binding 1 (calmyrin)), gene accession number (GeneBank accession No. ) NM_001779 (CD58, CD58 antigen, (lymphocyte function-associated antigen 3)), gene accession number (GeneBank accession No. ) CB055213 (ICOSLG, Inducible T-cell co-stimulator ligand), Gene accession number (GeneBank accession No. ) BX641029 (MASP1, Mannan-binding lectin serine peptidase 1 (C4 / C2 activating component of Ra-reactive factor)), GeneBank accession No. ) BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), Gene Accession No. ) BC039299 (STIP1, Stress-induced-phosphoprotein 1 (Hsp70 / Hsp90-organizing protein)), gene accession number (GeneBank accession No. ) AY055760 (DAF, Decay accelerating factor for complement (CD55, Cromer blood group system)), gene accession number (GeneBank accession No. ) AK130188 (FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog), Gene Accession No. ) AK095326 (MUS81, MUS81 endonuclease homolog (yeast)), gene accession number (GeneBank accession No. NM_017670 (OTUB1, OTU domain, ubiquitin aldehyde binding 1), gene registration number (GeneBank accession No. ) NM_003004 (SECTM1, Secreted and transmembrane 1), gene accession number (GeneBank accession No. ) NM_002309 (LIF, Hypothetical protein MGC20647), gene accession number (GeneBank accession No. ) NM_001421 (ELF4, E74-like factor 4 (ets domain transcription factor)), gene accession number (GeneBank accession No. ) NM_000418 (IL4R, Interleukin 4 receptor), gene accession number (GeneBank accession No. ) BI909222 (FCER1G, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), gene accession number (GeneBank accession No. ) BF569086 (NK4, Interleukin 32), gene accession number (GeneBank accession No. ) BC014470 (AZGP1, Alpha-2-glycoprotein 1, zinc), gene accession number (GeneBank accession No. ) BC020744 (AKR1C4, Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol), dehydrogenase 4), gene accession number (GeneBank accession No. ) BQ939577 (AKR1C3, Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)), gene accession number (GeneBank accession No. ) NM_000499 (CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), gene accession number (GeneBank accession No. ) NM_030622 (CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), gene accession number (GeneBank accession No. ) NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate), gene accession number (GeneBank accession No. ) NM_024307 (MGC4171, Hypothetical protein LOC283901), gene accession number (GeneBank accession No. ) NM_005336 (HDLBP, High density lipoprotein binding protein (vigilin)), gene registration number (GeneBank accession No. ) NM_002627 (PFKP, Phosphofructokinase, platelet), Gene Registration Number (GeneBank accession No. ) BX648281 (LDLR, low density lipoprotein receptor (familial hypercholesterolemia)), gene accession number (GeneBank accession No. ) BC069201 (FLJ22761, Hexokinase domain containing 1), gene accession number (GeneBank accession No. ) BC030207 (NR0B2, Nuclear receptor subfamily 0, group B, member 2), gene accession number (GeneBank accession No. ) AL833069 (KIAA1434, Hypothetical protein KIAA1434), gene accession number (GeneBank accession No. ) AK124656 (ENO2, Enolase 2 (gamma, neuronal)), gene accession number (GeneBank accession No. ) AK094474 (RHOC, Ras homolog gene family, member C), gene accession number (GeneBank accession No. ) AK093461 (ISYNA1, Myo-inositol 1-phosphate synthase A1), gene accession number (GeneBank accession No. ) AB053232 (GAL3ST3, Galactose-3-O-sulfotransferase 3), gene accession number (GeneBank accession No. ) AB045292 (TMEM8, Transmembrane protein 8 (five membrane-spanning domains)), gene accession number (GeneBank accession No. ) NM_004753 (DHRS3, Dehydrogenase / reductase (SDR family) member 3), Gene accession number (GeneBank accession No. ) NM_002900 (RBP3, Retinol binding protein 3, interstitial), gene accession number (GeneBank accession No. ) NM_001995 (ACSL1, Acyl-CoA synthetase long-chain family member 1), gene accession number (GeneBank accession No. NM_000018 (ACADVL, Acyl-Coenzyme A dehydrogenase, very long chain), gene accession number (GeneBank accession No. ) BC094756 (CRA, Myotubularin related protein 11), gene accession number (GeneBank accession No. ) BC050553 (NTE, Neuropathy target esterase), gene accession number (GeneBank accession No. ) BC033110 (HSD17B1, Hydroxysteroid (17-beta) dehydrogenase 1), Gene accession number (GeneBank accession No. ) AY268890 (TPP1, Tripeptidyl peptidase I), gene accession number (GeneBank accession No. ) AK172798 (CPT1A, Carnitine palmitoyltransferase 1A (liver)), gene accession number (GeneBank accession No. ) AK096809 (CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), gene accession number (GeneBank accession No. ) AK000600 (SIAT7D, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) -N-acetylgalactosaminide alpha-2,6-sialyltransferase 4), Gene accession number ) AB002454 (CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), gene accession number (GeneBank accession No. ) Z29093 (DDR1, Discoidin domain receptor family, member 1), gene accession number (GeneBank accession No. ) Z25424 (MKNK2, MAP kinase interacting serine / threonine kinase 2), gene accession number (GeneBank accession No. ) XM_291277 (DKFZp761P0423, Hypothetical protein DKFZp761P0423), gene accession number (GeneBank accession No. XM_038150 (MAST3, Microtubule associated serine / threonine kinase 3), gene accession number (GeneBank accession No. ) U88357 (ERBB3, V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)), gene accession number (GeneBank accession No. ) NM_025195 (TRIB1, Tribbles homolog 1 (Drosophila)), gene accession number (GeneBank accession No. ) NM_020639 (RIPK4, Receptor-interacting serine-threonine kinase 4), gene accession number (GeneBank accession No. ) NM_014172 (PHPT1, Phosphohistidine phosphatase 1), Gene accession number (GeneBank accession No. ) NM_006254 (PRKCD, Protein kinase C, delta), Gene accession number (GeneBank accession No. ) NM_005415 (SLC20A1, Solute carrier family 20 (phosphate transporter), member 1), gene accession number (GeneBank accession No. ) NM_005026 (PIK3CD, Phosphoinositide-3-kinase, catalytic, delta polypeptide), Gene accession number (GeneBank accession No. ) NM_004431 (EPHA2, EPH receptor A2), gene accession number (GeneBank accession No. ) NM_004419 (DUSP5, Dual specificity phosphatase 5), gene accession number (GeneBank accession No. ) NM_004327 (BCR, Breakpoint cluster region), Gene accession number (GeneBank accession No. ) NM_004231 (ATP6V1F, ATPase, H + transporting, lysosomal 14kDa, V1 subunit F), gene registration number (GeneBank accession No. ) NM_004090 (DUSP3, Dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)), gene accession number (GeneBank accession No. ) NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), gene accession number (GeneBank accession No. NM_002496 (NDUFS8, NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase)), gene accession number (GeneBank accession No. NM_001001852 (PIM3, Pim-3 oncogene), gene accession number (GeneBank accession No. ) L76191 (IRAK1, Interleukin-1 receptor-associated kinase 1), gene accession number (GeneBank accession No. ) D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), gene accession number (GeneBank accession No. ) BC065207 (ATP6V0D2, ATPase, H + transporting, lysosomal 38kDa, V0 subunit d isoform 2), gene accession number (GeneBank accession No. ) BC035578 (STK24, Serine / threonine kinase 24 (STE20 homolog, yeast)), gene accession number (GeneBank accession No. ) BC028724 (DUSP18, Dual specificity phosphatase 18), gene accession number (GeneBank accession No. AL117482 (ULK3, Unc-51-like kinase 3 (C.  elegans), GeneBank accession No. ) AK126879 (PCTK3, PCTAIRE protein kinase 3), gene accession number (GeneBank accession No. ) AB209416 (ILK, Integrin-linked kinase-2), gene accession number (GeneBank accession No. ) NM_000782 (CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1), gene accession number (GeneBank accession No. ) CR597101 (ZFP36, Zinc finger protein 36, C3H type, homolog (mouse)), Gene accession number (GeneBank accession No. ) CR936799 (FHL2, Four and a half LIM domains 2), gene accession number (GeneBank accession No. ) M24898 (NR1D1, Nuclear receptor subfamily 1, group D, member 1), gene accession number (GeneBank accession No. ) AF132818 (KLF5, Kruppel-like factor 5 (intestinal)), gene accession number (GeneBank accession No. ) AK055337 (ZNF213, Zinc finger protein 213), Gene accession number (GeneBank accession No. ) BC008834 (PHF1, PHD finger protein 1), gene accession number (GeneBank accession No. ) AK126918 (GLIS2, GLIS family zinc finger 2), Gene accession number (GeneBank accession No. ) BC042692 (CTL2, Solute carrier family 44, member 2), gene accession number (GeneBank accession No. ) NM_002224 (ITPR3, Inositol 1,4,5-triphosphate receptor, type 3), gene accession number (GeneBank accession No. ) AK095363 (AQP3, Aquaporin 3), gene accession number (GeneBank accession No. NM_174953 (ATP2A3, ATPase, Ca ++ transporting, ubiquitous), gene accession number (GeneBank accession No. ) BC042390 (VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B (yeast)), GeneBank Accession No. NM_016113 (TRPV2, Transient receptor potential cation channel, subfamily V, member 2), gene accession number (GeneBank accession No. ) BM926478 (RBP1, Retinol binding protein 1, cellular), gene accession number (GeneBank accession No. NM_000069 (CACNA1S, Calcium channel, voltage-dependent, L type, alpha 1S subunit), Gene Registration Number (GeneBank accession No. ) AK002107 (RAB3B, RAB3B, member RAS oncogene family), gene accession number (GeneBank accession No. ) NM_013321 (SNX8, Sorting nexin 8), Gene accession number (GeneBank accession No. ) AK125026 (SLC6A12, Solute carrier family 6 (neurotransmitter transporter, betaine / GABA), member 12), gene accession number (GeneBank accession No. ) NM_005843 (STAM2, Signal transducing adapter molecule (SH3 domain and ITAM motif) 2), gene accession number (GeneBank accession No. ) AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), gene accession number (GeneBank accession No. ) U49248 (ABCC2, ATP-binding cassette, sub-family C (CFTR / MRP), member 2), gene accession number (GeneBank accession No. ) AK172792 (SCNN1A, Sodium channel, nonvoltage-gated 1 alpha), gene accession number (GeneBank accession No. ) BC044656 (CASC3, Cancer susceptibility candidate 3), gene accession number (GeneBank accession No. NM_203403 (C9orf150, Chromosome 9 open reading frame 150), gene accession number (GeneBank accession No. NM_080388 (S100A16, S100 calcium binding protein A16), gene registration number (GeneBank accession No. NM_031286 (SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), gene accession number (GeneBank accession No. NM_022153 (PP2135, Chromosome 10 open reading frame 54), gene accession number (GeneBank accession No. ) NM_004864 (GDF15, Growth differentiation factor 15), Gene accession number (GeneBank accession No. ) NM_003330 (TXNRD1, Thioredoxin reductase 1), gene accession number (GeneBank accession No. ) NM_001013632 (LOC343521, Similar to hypothetical protein 4833401D15), gene accession number (GeneBank accession No. ) BX537968 (LOC51149, Hypothetical LOC51149), gene accession number (GeneBank accession No. BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), gene accession number (GeneBank accession No. ) BQ683841 (S100A11, S100 calcium binding protein A11 (calgizzarin)), gene accession number (GeneBank accession No. ) BQ276852 (TMSB10, Thymosin, beta 10), gene accession number (GeneBank accession No. ) AK126182 (KIAA1949, KIAA1949), gene accession number (GeneBank accession No. ) AK124751 (CAPN2, Calpain 2, (m / II) large subunit), gene accession number (GeneBank accession No. ) AK095079 (RGC32, Response gene to complement 32), gene accession number (GeneBank accession No. ) AB075871 (FLJ42654, Golgi transport 1 homolog A (S.  cerevisiae)), gene accession number (GeneBank accession No. ) AK125150 (MAPK8, Mitogen-activated protein kinase 8), gene registration number (GeneBank accession No. ) NM_002758 (MAP2K6, Mitogen-activated protein kinase kinase 6), gene accession number (GeneBank accession No. ) NM_004612 (TGFBR1, Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kDa)), gene accession number (GeneBank accession No. NM_145686 (MAP4K4, Mitogen-activated protein kinase kinase kinase kinase 4), gene accession number (GeneBank accession No. ) XM_042066 (MAP3K1, Mitogen-activated protein kinase kinase kinase 1), gene accession number (GeneBank accession No. ) AB011123 (TNIK, TRAF2 and NCK interacting kinase), gene accession number (GeneBank accession No. ) AB209031 (C5, Complement component 5), gene accession number (GeneBank accession No. NM_022740 (HIPK2, Homeodomain interacting protein kinase 2), gene accession number (GeneBank accession No. ) NM_148957 (TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), gene accession number (GeneBank accession No. ) AB208909 (ITGB2, Integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)), GeneBank accession No. ) AB209211 (TIA1, TIA1 cytotoxic granule-associated RNA binding protein), gene accession number (GeneBank accession No. ) AB209613 (DNASE1L3, Deoxyribonuclease I-like 3), Gene accession number (GeneBank accession No. ) AK122825 (HMGB1, High-mobility group box 1), gene accession number (GeneBank accession No. ) AK127326 (PHF17, PHD finger protein 17), gene accession number (GeneBank accession No. ) AK223503 (CASP1, Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)), gene accession number (GeneBank accession No. ) BC013326 (GAS2, Growth arrest-specific 2), Gene accession number (GeneBank accession No. ) BC047698 (IL7, Interleukin 7), gene accession number (GeneBank accession No. D79987 (ESPL1, Extra spindle poles like 1 (S.  cerevisiae)), gene accession number (GeneBank accession No. ) NM_000893 (KNG1, Kininogen 1), gene accession number (GeneBank accession No. ) NM_001012271 (BIRC5, Effector cell peptidase receptor 1), gene accession number (GeneBank accession No. ) NM_004938 (DAPK1, Death-associated protein kinase 1), gene accession number (GeneBank accession No. NM_005879 (TRIP, TRAF interacting protein), gene accession number (GeneBank accession No. NM_014739 (BCLAF1, BCL2-associated transcription factor 1), gene accession number (GeneBank accession No. ) NM_018947 (CYCS, Cytochrome c, somatic), Gene accession number (GeneBank accession No. ) AB033337 (MPHOSPH1, M-phase phosphoprotein 1), gene accession number (GeneBank accession No. ) AB209179 (PLK1, Polo-like kinase 1 (Drosophila)), gene accession number (GeneBank accession No. ) AB209337 (CDC7, CDC7 cell division cycle 7 (S.  cerevisiae)), gene accession number (GeneBank accession No. ) AF053305 (BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)), gene accession number (GeneBank accession No. ) AF053306 (BUB1B, BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)), Gene Accession No. ) AF345347 (SPAG5, Sperm associated antigen 5), gene accession number (GeneBank accession No. ) AK092638 (CCNG2, Cyclin G2), gene accession number (GeneBank accession No. ) AK222819 (NUSAP1, Nucleolar and spindle associated protein 1), gene accession number (GeneBank accession No. ) AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1 (yeast)), gene accession number (GeneBank accession No. ) AY257469 (CIT, Citron (rho-interacting, serine / threonine kinase 21)), gene accession number (GeneBank accession No. ) AY367065 (ASPM, Abnormal Spindle-like, microcephaly associated (Drosophila)), GeneBank Accession No. ) BC011000 (CDCA5, Cell division cycle associated 5), gene accession number (GeneBank accession No. ) BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), gene accession number (GeneBank accession No. ) BC043502 (NEK2, never in mitosis gene a) -related kinase 2), gene accession number (GeneBank accession No. BU675073 (PTTG1, Pituitary tumor-transforming 1), gene accession number (GeneBank accession No. ) BX647885 (STMN1, Stathmin 1 / oncoprotein 18), gene accession number (GeneBank accession No. ) CR592757 (BRRN1, Barren homolog 1 (Drosophila)), gene accession number (GeneBank accession No. CR597075 (MAPRE2, Microtubule-associated protein, RP / EB family, member 2), gene accession number (GeneBank accession No. ) CR604810 (CCNA2, Cyclin A2), gene accession number (GeneBank accession No. CR933728 (CDC2, Cell division cycle 2, G1 to S and G2 to M), Gene accession number (GeneBank accession No. ) NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase), gene accession number (GeneBank accession No. ) NM_001790 (CDC25C, Cell division cycle 25C), Gene accession number (GeneBank accession No. NM_001798 (CDK2, Cyclin-dependent kinase 2), gene accession number (GeneBank accession No. ) NM_001813 (CENPE, Centromere protein E, 312kDa), Gene accession number (GeneBank accession No. ) NM_003318 (TTK, TTK protein kinase), gene accession number (GeneBank accession No. ) NM_003981 (PRC1, Protein regulator of cytokinesis 1), gene accession number (GeneBank accession No. NM_004523 (KIF11, Kinesin family member 11), gene accession number (GeneBank accession No. ) NM_004701 (CCNB2, Cyclin B2), gene accession number (GeneBank accession No. ) NM_005983 (SKP2, S-phase kinase-associated protein 2 (p45)), gene accession number (GeneBank accession No. NM_006101 (KNTC2, Kinetochore associated 2), gene accession number (GeneBank accession No. ) NM_006845 (KIF2C, Kinesin family member 2C), gene accession number (GeneBank accession No. ) NM_007375 (TARDBP, TAR DNA binding protein), gene registration number (GeneBank accession No. ) NM_012112 (TPX2, TPX2, microtubule-associated, homolog (Xenopus laevis)), gene accession number (GeneBank accession No. ) NM_014750 (DLG7, Discs, large homolog 7 (Drosophila)), gene accession number (GeneBank accession No. ) NM_015097 (CLASP2, Cytoplasmic linker associated protein 2), gene accession number (GeneBank accession No. ) NM_016343 (CENPF, Centromere protein F, 350 / 400ka (mitosin)), gene accession number (GeneBank accession No. NM_016426 (GTSE1, G-2 and S-phase expressed 1), gene accession number (GeneBank accession No. ) NM_018492 (PBK, PDZ binding kinase), gene accession number (GeneBank accession No. NM_018685 (ANLN, Anillin, actin binding protein (scraps homolog, Drosophila)), gene accession number (GeneBank accession No. ) NM_020242 (KNSL7, Kinesin family member 15), gene accession number (GeneBank accession No. ) NM_031966 (CCNB1, Cyclin B1), gene accession number (GeneBank accession No. NM_138555 (KIF23, Kinesin family member 23), gene accession number (GeneBank accession No. ) U65410 (MAD2L1, MAD2 mitotic arrest deficient-like 1 (yeast)), gene accession number (GeneBank accession No. ) AB020656 (CYLD, Cylindromatosis (turban tumor syndrome)), gene accession number (GeneBank accession No. ) AF033122 (SESN1, Sestrin 1), gene accession number (GeneBank accession No. ) AK074377 (UHRF1, Chromosome 19 open reading frame 31), gene accession number (GeneBank accession No. ) AK091170 (CDKN2C, Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)), gene accession number (GeneBank accession No. ) AK094323 (NFYC, Nuclear transcription factor Y, gamma), gene accession number (GeneBank accession No. ) AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No. ) BC033086 (TCF19, Transcription factor 19 (SC1)), gene accession number (GeneBank accession No. ) BC040303 (PTP4A1, Protein tyrosine phosphatase type IVA, member 1), Gene accession number (GeneBank accession No. ) BC040991 (TFDP2, Transcription factor Dp-2 (E2F dimerization partner 2)), gene accession number (GeneBank accession No. BC092412 (SGOL2, Shugoshin-like 2 (S.  pombe), GeneBank accession No. ) BQ278454 (CKS1B, CDC28 protein kinase regulatory subunit 1B), gene accession number (GeneBank accession No. ) BX649128 (SESN3, Sestrin 3), gene accession number (GeneBank accession No. ) CD049340 (AURKB, Aurora kinase B), gene accession number (GeneBank accession No. ) M89914 (NF1, Neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)), gene accession number (GeneBank accession No. NM_001005414 (ZWINT, ZW10 interactor antisense), gene accession number (GeneBank accession No. ) NM_001008491 (Sep 2, Septin 2), gene accession number (GeneBank accession No. NM_001274 (CHEK1, CHK1 checkpoint homolog (S.  pombe), GeneBank accession No. NM_002105 (H2AFX, H2A histone family, member X), gene accession number (GeneBank accession No. NM_002388 (MCM3, MCM3 minichromosome maintenance deficient 3 (S.  cerevisiae)), gene accession number (GeneBank accession No. NM_002417 (MKI67, Antigen identified by monoclonal antibody Ki-67), gene accession number (GeneBank accession No. NM_002875 (RAD51, RAD51 homolog (RecA homolog, E.  coli) (S.  cerevisiae)), gene accession number (GeneBank accession No. NM_003884 (PCAF, P300 / CBP-associated factor), gene accession number (GeneBank accession No. NM_004526 (MCM2, MCM2 minichromosome maintenance deficient 2, mitotin (S.  cerevisiae)), gene accession number (GeneBank accession No. ) NM_004847 (AIF1, Allograft inflammatory factor 1), gene accession number (GeneBank accession No. NM_005915 (MCM6, MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S.  pombe) (S.  cerevisiae)), gene accession number (GeneBank accession No. ) NM_012090 (MACF1, Microtubule-actin crosslinking factor 1), Gene Registration Number (GeneBank accession No. NM_012415 (RAD54B, RAD54 homolog B (S.  cerevisiae)), gene accession number (GeneBank accession No. ) NM_014264 (PLK4, Polo-like kinase 4 (Drosophila)), gene accession number (GeneBank accession No. ) NM_015714 (G0S2, G0 / G1switch 2), gene accession number (GeneBank accession No. NM_024680 (FLJ23311, E2F transcription factor 8), gene accession number (GeneBank accession No. XM_034274 (MYBL1, V-myb myeloblastosis viral oncogene homolog (avian) -like 1), gene accession number (GeneBank accession No. ) AK001720 (FLJ10858, Nei endonuclease VIII-like 3 (E.  coli)), and GeneBank accession No. ) AY032677 (POLQ, Polymerase (DNA directed), theta), Gene Accession No. ) BC034480 (BLM, Bloom syndrome), Gene accession number (GeneBank accession No. BC073161 (RAD51C, RAD51 homolog C (S.  cerevisiae)), gene accession number (GeneBank accession No. CR600021 (HMGB2, High-mobility group box 2), gene accession number (GeneBank accession No. CR625391 (RAD51AP1, RAD51 associated protein 1), gene accession number (GeneBank accession No. CR936783 (FLJ40869, Hypothetical protein LOC284952), gene accession number (GeneBank accession No. ) DQ140356 (KIAA1596, Fanconi anemia, complementation group M), gene accession number (GeneBank accession No. ) NM_001067 (TOP2A, Topoisomerase (DNA) II alpha 170kDa), gene accession number (GeneBank accession No. ) NM_001618 (PARP1, Poly (ADP-ribose) polymerase family, member 1), gene accession number (GeneBank accession No. ) NM_003362 (UNG, Uracil-DNA glycosylase), gene accession number (GeneBank accession No. ) NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), Gene accession number (GeneBank accession No. ) NM_130398 (EXO1, Exonuclease 1), gene accession number (GeneBank accession No. ) AB020807 (TLR6, Toll-like receptor 6), gene accession number (GeneBank accession No. ) AB032980 (DCDC2, Doublecortin domain containing 2), gene accession number (GeneBank accession No. ) AB209866 (TFPI, Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)), gene accession number (GeneBank accession No. ) AK057015 (HSPA4, Heat shock 70kDa protein 4), Gene accession number (GeneBank accession No. ) AK095515 (IFIT1, Interferon-induced protein with tetratricopeptide repeats 1), gene accession number (GeneBank accession No. ) AK122686 (IF, I factor (complement), gene accession number (GeneBank accession No. ) AK123010 (RRM2, Ribonucleotide reductase M2 polypeptide), gene accession number (GeneBank accession No. ) BC035582 (TRIM22, Tripartite motif-containing 22), gene accession number (GeneBank accession No. ) BX537894 (LOC493869, Similar to RIKEN cDNA 2310016C16), gene accession number (GeneBank accession No. ) M14338 (PROS1, Protein S (alpha)), gene accession number (GeneBank accession No. ) NM_000821 (GGCX, Gamma-glutamyl carboxylase), gene accession number (GeneBank accession No. ) NM_000963 (PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G / H synthase and cyclooxygenase)), Gene Accession No. NM_001001547 (CD36, CD36 antigen (collagen type I receptor, thrombospondin receptor)), gene accession number (GeneBank accession No. NM_001512 (GSTA4, Glutathione S-transferase A4), gene accession number (GeneBank accession No. NM_001629 (ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), gene accession number (GeneBank accession No. ) NM_001752 (CAT, Catalase), gene accession number (GeneBank accession No. NM_001837 (CCR3, Chemokine (C-C motif) receptor 3), gene accession number (GeneBank accession No. ) NM_001979 (EPHX2, Epoxide hydrolase 2, cytoplasmic), gene registration number (GeneBank accession No. ) NM_001994 (F13B, Coagulation factor XIII, B polypeptide), gene accession number (GeneBank accession No. ) NM_002182 (IL1RAP, Interleukin 1 receptor accessory protein), gene accession number (GeneBank accession No. ) NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), Gene accession number (GeneBank accession No. NM_173216 (SIAT1, ST6 beta-galactosamide alpha-2,6-sylyltranferase 1), gene accession number (GeneBank accession No. NM_202002 (FOXM1, Forkhead box M1), gene accession number (GeneBank accession No. ) AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase), Gene accession number (GeneBank accession No. ) BC027881 (AFP, Alpha-fetoprotein), gene accession number (GeneBank accession No. ) NM_015915 (SPG3A, Spastic paraplegia 3A (autosomal dominant)), gene accession number (GeneBank accession No. ) NM_000671 (ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), gene registration number (GeneBank accession No. ) J05428 (UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), gene accession number (GeneBank accession No. ) NM_000672 (ADH6, Alcohol dehydrogenase 6 (class V)), gene accession number (GeneBank accession No. ) M15943 (ADH4, Alcohol dehydrogenase 4 (class II), pi polypeptide), gene accession number (GeneBank accession No. ) AK223395 (FBP1, Fructose-1,6-bisphosphatase 1), gene accession number (GeneBank accession No. NM_000151 (G6PC, Glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)), gene accession number (GeneBank accession No. XM_113962 (KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), gene accession number (GeneBank accession No. ) AB020644 (ACSL6, Acyl-CoA synthetase long-chain family member 6), gene accession number (GeneBank accession No. ) AB209907 (PLD1, Phospholipase D1, phophatidylcholine-specific), gene accession number (GeneBank accession No. ) AF285167 (ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1), gene accession number (GeneBank accession No. ) AF297872 (TRERF1, Transcriptional regulating factor 1), gene registration number (GeneBank accession No. ) AF303134 (ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), gene accession number (GeneBank accession No. ) AF339053 (PLA2G12B, Phospholipase A2, group XIIB), gene accession number (GeneBank accession No. ) AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), gene accession number (GeneBank accession No. ) AK124635 (PCSK9, Proprotein convertase subtilisin / kexin type 9), gene registration number (GeneBank accession No. ) AK127346 (SIAT9, ST3 beta-galactoside alpha-2,3- sialyltransferase 5), gene accession number (GeneBank accession No. ) AL359559 (AGPS, Alkylglycerone phosphate synthase), gene accession number (GeneBank accession No. ) AY691170 (PLCL3, Phospholipase C-like 3), gene accession number (GeneBank accession No. ) BG567934 (APOM, Apolipoprotein M), gene accession number (GeneBank accession No. ) BX538214 (C6orf167, Chromosome 6 open reading frame 167), gene accession number (GeneBank accession No. ) BX640945 (FADS2, Fatty acid desaturase 2), gene accession number (GeneBank accession No. ) BX648473 (PIGK, Phosphatidylinositol glycan, class K), gene accession number (GeneBank accession No. ) BX648557 (HSD17B2, Hydroxysteroid (17-beta) dehydrogenase 2), Gene accession number (GeneBank accession No. ) CR749601 (ETNK1, Death-associated protein kinase 3), gene accession number (GeneBank accession No. ) NM_000859 (HMGCR, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase), gene accession number (GeneBank accession No. ) NM_001443 (FABP1, Fatty acid binding protein 1, liver), gene accession number (GeneBank accession No. ) NM_002130 (HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)), gene accession number (GeneBank accession No. ) NM_003725 (RODH, Hydroxysteroid (17-beta) dehydrogenase 6), Gene accession number (GeneBank accession No. NM_004845 (PCYT1B, Phosphate cytidylyltransferase 1, choline, beta), Gene accession number (GeneBank accession No. ) NM_014762 (DHCR24, 24-dehydrocholesterol reductase), gene accession number (GeneBank accession No. ) NM_020139 (DHRS6, Dehydrogenase / reductase (SDR family) member 6), gene registration number (GeneBank accession No. NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), gene accession number (GeneBank accession No. NM_032523 (OSBPL6, Oxysterol binding protein-like 6), gene accession number (GeneBank accession No. ) NM_033505 (SELI, Selenoprotein I), gene accession number (GeneBank accession No. ) Z28339 (AKR1D1, Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)), GeneBank accession No. ) AK024899 (ENPP3, Ectonucleotide pyrophosphatase / phosphodiesterase 3), gene accession number (GeneBank accession No. ) AK025546 (PTPN4, Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)), Gene accession number (GeneBank accession No. ) AK124910 (ENPP2, Ectonucleotide pyrophosphatase / phosphodiesterase 2 (autotaxin)), gene accession number (GeneBank accession No. ) BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538), gene registration number (GeneBank accession No. ) BC050565 (PASK, PAS domain containing serine / threonine kinase), gene accession number (GeneBank accession No. ) L13436 (NPR2, Natriuretic peptide receptor B / guanylate cyclase B (atrionatriuretic peptide receptor B)), gene accession number (GeneBank accession No. ) NM_001005862 (ERBB2, V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro / glioblastoma derived oncogene homolog (avian)), gene accession number (GeneBank accession No. NM_005012 (ROR1, Receptor tyrosine kinase-like orphan receptor 1), gene accession number (GeneBank accession No. NM_006035 (CDC42BPB, CDC42 binding protein kinase beta (DMPK-like)), gene accession number (GeneBank accession No. NM_014791 (MELK, Maternal embryonic leucine zipper kinase), gene accession number (GeneBank accession No. NM_023028 (FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), gene registration number (GeneBank accession No. ) NM_080836 (STK35, Serine / threonine kinase 35), gene accession number (GeneBank accession No. ) AF419331 (FUSIP1, FUS interacting protein (serine / arginine-rich) 1), gene accession number (GeneBank accession No. ) AK091927 (SFRS3, Splicing factor, arginine / serine-rich 3), gene accession number (GeneBank accession No. ) BC010266 (HNRNPA1, Heterogeneous nuclear ribonucleoprotein A1), gene accession number (GeneBank accession No. ) BC012360 (CTAGE5, CTAGE family, member 5), gene accession number (GeneBank accession No. ) BC036046 (PLRG1, Pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)), gene accession number (GeneBank accession No. BC065384 (PCF11, PCF11, cleavage and polyadenylation factor subunit, homolog (S.  cerevisiae)), gene accession number (GeneBank accession No. ) BX537360 (CPSF5, Nudix (nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No. ) BX537494 (HNRPA2B1, Heterogeneous nuclear ribonucleoprotein A2 / B1), gene accession number (GeneBank accession No. ) BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), gene registration number (GeneBank accession No. ) CA455267 (PPIH, Peptidyl prolyl isomerase H (cyclophilin H)), gene accession number (GeneBank accession No. ) CR596214 (HNRPA0, Heterogeneous nuclear ribonucleoprotein A0), gene accession number (GeneBank accession No. NM_001326 (CSTF3, Hypothetical protein LOC283267), gene accession number (GeneBank accession No. ) NM_004640 (BAT1, HLA-B associated transcript 1), gene accession number (GeneBank accession No. NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), gene accession number (GeneBank accession No. ) NM_006924 (SFRS1, Splicing factor, arginine / serine-rich 1 (splicing factor 2, alternate splicing factor)), gene accession number (GeneBank accession No. ) NM_012426 (SF3B3, Splicing factor 3b, subunit 3, 130 kDa), Gene accession number (GeneBank accession No. NM_018048 (FLJ10292, Mago-nashi homolog), gene accession number (GeneBank accession No. NM_030919 (C20orf129, Chromosome 20 open reading frame 129), gene accession number (GeneBank accession No. ) NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37 kDa)), gene registration number (GeneBank accession No. ) NM_138933 (ACF, Apobec-1 complementation factor), gene accession number (GeneBank accession No. ) AB193259 (ACE2, Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2), gene accession number (GeneBank accession No. ) BX648769 (EWSR1, Ewing sarcoma breakpoint region 1), gene accession number (GeneBank accession No. ) AB023154 (DTX4, Deltex 4 homolog (Drosophila)), gene accession number (GeneBank accession No. ) AL543755 (VAV3, Vav 3 oncogene), gene accession number (GeneBank accession No. ) M75106 (CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), gene accession number (GeneBank accession No. NM_021045 (ZNF248, Zinc finger protein 248), gene accession number (GeneBank accession No. ) AB209194 (B4GALT6, UDP-Gal: betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6), gene accession number (GeneBank accession No. ) AF279145 (ANTXR1, Anthrax toxin receptor 1), gene accession number (GeneBank accession No. ) NM_025074 (FRAS1, Fraser syndrome 1), gene accession number (GeneBank accession No. ) AK025790 (KIF20A, Kinesin family member 20A), gene accession number (GeneBank accession No. ) NM_006152 (LRMP, Lymphoid-restricted membrane protein), gene accession number (GeneBank accession No. ) NM_000340 (SLC2A2, Solute carrier family 2 (facilitated glucose transporter), member 2), gene accession number (GeneBank accession No. ) AF071592 (KIF4A, Kinesin family member 4A), gene accession number (GeneBank accession No. NM_013277 (RACGAP1, Rac GTPase activating protein 1), gene accession number (GeneBank accession No. ) AY043484 (SCN1A, Sodium channel, voltage-gated, type I, alpha), Gene Registration Number (GeneBank accession No. ) AY791349 (KIF18A, Kinesin family member 18A), gene accession number (GeneBank accession No. ) NM_018018 (SLC38A4, Solute carrier family 38, member 4), gene accession number (GeneBank accession No. ) AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ), Gene accession number (GeneBank accession No. NM_021069 (ARGBP2, Sorbin and SH3 domain containing 2), gene accession number (GeneBank accession No. NM_001005747 (CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), Gene accession number (GeneBank accession No. ) AJ496568 (SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), gene accession number (GeneBank accession No. ) NM_030641 (APOL6, Apolipoprotein L, 6), gene accession number (GeneBank accession No. NM_173512 (FLJ39822, Hypothetical protein FLJ39822), gene accession number (GeneBank accession No. ) NM_000037 (ANK1, Ankyrin 1, erythrocytic), gene accession number (GeneBank accession No. ) NM_001011554 (SLC13A3, Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3), gene accession number (GeneBank accession No. ) AB091343 (C10orf3, Centrosomal protein 55kDa), gene accession number (GeneBank accession No. ) AK000643 (ASB9, Ankyrin repeat and SOCS box-containing 9), gene accession number (GeneBank accession No. ) AK055221 (FBXO5, F-box protein 5), gene accession number (GeneBank accession No. ) AK075271 (SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2)), gene accession number (GeneBank accession No. ) AK122685 (GLUD1, Glutamate dehydrogenase 1), gene accession number (GeneBank accession No. ) AK127098 (FLJ10706, Chromosome 1 open reading frame 112), gene accession number (GeneBank accession No. ) AL133031 (MLR1, Transcription factor MLR1), gene accession number (GeneBank accession No. ) AY007723 (MAL2, Mal, T-cell differentiation protein 2), gene accession number (GeneBank accession No. BC022255 (Spc25, Spindle pole body component 25 homolog (S.  cerevisiae)), gene accession number (GeneBank accession No. ) BC041882 (ATF7IP2, Activating transcription factor 7 interacting protein 2), gene accession number (GeneBank accession No. ) BC052951 (LMNB1, Lamin B1), gene accession number (GeneBank accession No. ) BC098313 (FLJ20641, Hypothetical protein FLJ20641), gene accession number (GeneBank accession No. ) NM_001809 (CENPA, Centromere protein A, 17kDa), gene accession number (GeneBank accession No. NM_145061 (C13orf3, Chromosome 13 open reading frame 3), gene accession number (GeneBank accession No. XM_372695 (LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859), mRNA).

1) Biomarker genes whose expression is increased by exposure of phenanthrene in the biomarkers are as follows:

Gene accession number (GeneBank accession No. ) NM_004420 (DUSP8, Dual specificity phosphatase 8), gene accession number (GeneBank accession No. ) L11329 (DUSP2, Dual specificity phosphatase 2), gene accession number (GeneBank accession No. ) BC094766 (PKN1, Protein kinase N1), gene accession number (GeneBank accession No. ) AY247738 (TRIB3, Tribbles homolog 3 (Drosophila)), gene accession number (GeneBank accession No. ) AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), Gene Accession No. ) AB208849 (SHC1, Src homology 2 domain containing (SHC) transforming protein 1), gene accession number (GeneBank accession No. ) X02812 (TGFB1, Transforming growth factor, beta 1 (Camurati-Engelmann disease)), Gene Accession No. ) NM_198951 (TGM2, Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)), gene registration number (GeneBank accession No. NM_147780 (CTSB, Cathepsin B), gene accession number (GeneBank accession No. NM_078467 (CDKN1A, Cyclin-dependent kinase inhibitor 1A (p21, Cip1)), gene accession number (GeneBank accession No. NM_033027 (AXUD1, AXIN1 up-regulated 1), gene accession number (GeneBank accession No. NM_032797 (AMID, Apoptosis-inducing factor (AIF) -like mitochondrion-associated inducer of death), GeneBank accession No. ) NM_021960 (MCL1, Myeloid cell leukemia sequence 1 (BCL2-related)), gene registration number (GeneBank accession No. ) NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), gene accession number (GeneBank accession No. ) NM_016222 (DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41), gene accession number (GeneBank accession No. ) NM_013246 (CLC, Cardiotrophin-like cytokine factor 1), gene accession number (GeneBank accession No. ) NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), gene registration number (GeneBank accession No. ) NM_004281 (BAG3, BCL2-associated athanogene 3), gene accession number (GeneBank accession No. ) NM_003897 (IER3, Immediate early response 3), Gene accession number (GeneBank accession No. ) NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), gene accession number (GeneBank accession No. ) NM_003639 (IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No. ) NM_003311 (PHLDA2, Pleckstrin homology-like domain, family A, member 2), gene accession number (GeneBank accession No. ) NM_002737 (PRKCA, Protein Kinase C, alpha), Gene Accession Number (GeneBank accession No. NM_002648 (PIM1, Pim-1 oncogene), gene accession number (GeneBank accession No. NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), gene accession number (GeneBank accession No. ) NM_002305 (LGALS1, Lectin, galactoside-binding, soluble, 1 (galectin 1)), gene accession number (GeneBank accession No. ) NM_001013398 (IGFBP3, Insulin-like growth factor binding protein 3), gene registration number (GeneBank accession No. ) BX640923 (MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)), gene accession number (GeneBank accession No. ) BX537586 (STK17A, Serine / threonine kinase 17a (apoptosis-inducing)), gene accession number (GeneBank accession No. ) BG284742 (P8, P8 protein (candidate of metastasis 1)), gene accession number (GeneBank accession No. ) BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), gene accession number (GeneBank accession No. ) BC027949 (P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), gene accession number (GeneBank accession No. ) BC006365 (PSEN2, Presenilin 2 (Alzheimer disease 4)), gene accession number (GeneBank accession No. ) AY869712 (PPP1R13L, Protein phosphatase 1, regulatory (inhibitor) subunit 13 like), Gene Accession No. ) AY028896 (CARD10, Caspase recruitment domain family, member 10), gene accession number (GeneBank accession No. ) AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), gene accession number (GeneBank accession No. ) AK092872 (ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), gene registration number (GeneBank accession No. ) AK092808 (RRAGC, Ras-related GTP binding C), gene accession number (GeneBank accession No. ) AJ001898 (GDNF, Glial cell derived neurotrophic factor), gene accession number (GeneBank accession No. ) AF220656 (PHLDA1, Pleckstrin homology-like domain, family A, member 1), gene accession number (GeneBank accession No. AF055634 (UNC5C, Unc-5 homolog C (C.  elegans), GeneBank accession No. ) AB209485 (Vescular endothelial growth factor), gene accession number (GeneBank accession No. ) AB096256 (UNC5B, Unc-5 homolog B (C.  elegans), GeneBank accession No. ) AB007960 (SH3GLB1, SH3-domain GRB2-like endophilin B1), gene accession number (GeneBank accession No. ) X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), Gene accession number (GeneBank accession No. ) S62138 (DDIT3, DNA-damage-inducible transcript 3), gene accession number (GeneBank accession No. NM_078487 (CDKN2B, Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)), gene accession number (GeneBank accession No. ) NM_012127 (CIZ1, CDKN1A interacting zinc finger protein 1), gene accession number (GeneBank accession No. ) NM_005883 (APC2, Adenomatosis polyposis coli 2), gene accession number (GeneBank accession No. ) NM_004196 (CDKL1, Cyclin-dependent kinase-like 1 (CDC2-related kinase)), gene accession number (GeneBank accession No. ) NM_003236 (TGFA, Transforming growth factor, alpha), gene registration number (GeneBank accession No. ) NM_001261 (CDK9, Cyclin-dependent kinase 9 (CDC2-related kinase)), gene accession number (GeneBank accession No. ) NM_001007271 (DUSP13, Dual specificity phosphatase 13), gene accession number (GeneBank accession No. CR749511 (PARC, P53-associated parkin-like cytoplasmic protein), gene accession number (GeneBank accession No. CR623038 (ID2, Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), gene accession number (GeneBank accession No. CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No. ) BF965144 (IFITM1, Interferon induced transmembrane protein 1 (9-27)), gene accession number (GeneBank accession No. ) AK127679 (DUSP1, Dual specificity phosphatase 1), gene accession number (GeneBank accession No. ) AK096276 (CCND3, Cyclin D3), gene accession number (GeneBank accession No. ) AB209586 (MAPK13, Mitogen-activated protein kinase 13), gene accession number (GeneBank accession No. ) AB209465 (PCTK1, PCTAIRE protein kinase 1), gene accession number (GeneBank accession No. ) Z19588 (SKIL, SKI-like), gene accession number (GeneBank accession No. NM_020429 (SMURF1, SMAD specific E3 ubiquitin protein ligase 1), gene accession number (GeneBank accession No. ) NM_014767 (SPOCK2, Sparc / osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), Gene Accession No. ) NM_005979 (S100A13, S100 calcium binding protein A13), gene registration number (GeneBank accession No. NM_005187 (CBFA2T3, Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), gene accession number (GeneBank accession No. ) NM_004364 (CEBPA, CCAAT / enhancer binding protein (C / EBP), alpha), gene registration number (GeneBank accession No. ) NM_001769 (CD9, CD9 antigen (p24)), gene accession number (GeneBank accession No. ) NM_001718 (BMP6, Bone morphogenetic protein 6), gene accession number (GeneBank accession No. ) NM_000641 (IL11, Interleukin 11), gene accession number (GeneBank accession No. ) BX647459 (SERPINE2, Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2), gene registration number (GeneBank accession No. ) BQ066037 (RPS19, Ribosomal protein S19), gene accession number (GeneBank accession No. ) BE791300 (EDF1, Endothelial differentiation-related factor 1), Gene accession number (GeneBank accession No. ) BC038504 (SNF1LK, SNF1-like kinase), gene accession number (GeneBank accession No. ) AL832287 (ZAP70, Zeta-chain (TCR) associated protein kinase 70kDa), gene accession number (GeneBank accession No. ) AK125742 (PCGF1, Polycomb group ring finger 1), gene accession number (GeneBank accession No. ) AK124709 (NDRG1, N-myc downstream regulated gene 1), gene accession number (GeneBank accession No. ) AB011157 (PTDSR, Phosphatidylserine receptor), Gene Accession No. NM_013255 (MKLN1, Muskelin 1, intracellular mediator containing kelch motifs), gene accession number (GeneBank accession No. ) NM_006572 (GNA13, Guanine nucleotide binding protein (G protein), alpha 13), gene registration number (GeneBank accession No. NM_002211 (ITGB1, Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)), gene accession number (GeneBank accession No. ) CR601067 (PLAUR, Plasminogen activator, urokinase receptor), gene accession number (GeneBank accession No. ) BC050456 (THBS4, Thrombospondin 4), gene accession number (GeneBank accession No. ) AK027389 (CXCL16, Chemokine (C-X-C motif) ligand 16), gene accession number (GeneBank accession No. ) AJ132099 (VNN1, Vanin 1), gene accession number (GeneBank accession No. ) XM_371354 (FLJ10157, Hypothetical protein FLJ10157), gene accession number (GeneBank accession No. ) XM_208313 (TPM3, Similar to tropomyosin 4), gene accession number (GeneBank accession No. XM_208270 (ACR, Acrosin-like protease), gene accession number (GeneBank accession No. ) NM_203353 (PDLIM7, PDZ and LIM domain 7 (enigma)), gene accession number (GeneBank accession No. ) NM_201382 (PLEC1, Plectin 1, intermediate filament binding protein 500kDa), gene registration number (GeneBank accession No. ) NM_182961 (SYNE1, Spectrin repeat containing, nuclear envelope 1), gene accession number (GeneBank accession No. ) NM_181826 (NF2, Neurofibromin 2 (bilateral acoustic neuroma)), gene accession number (GeneBank accession No. NM_172069 (PLEKHH2, Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2), gene accession number (GeneBank accession No. ) NM_022648 (TNS, Tensin 1), gene accession number (GeneBank accession No. NM_017556 (FBLP-1, Filamin binding LIM protein 1), gene accession number (GeneBank accession No. NM_016081 (KIAA0992, Palladin, cytoskeletal associated protein), gene accession number (GeneBank accession No. ) NM_006617 (NES, Nestin), gene accession number (GeneBank accession No. ) NM_006262 (PRPH, Peripherin), gene accession number (GeneBank accession No. NM_005100 (AKAP12, A kinase (PRKA) anchor protein (gravin) 12), gene accession number (GeneBank accession No. NM_004368 (CNN2, Calponin 2), gene accession number (GeneBank accession No. ) NM_003388 (CYLN2, Cytoplasmic linker 2), gene accession number (GeneBank accession No. ) NM_003370 (VASP, Vasodilator-stimulated phosphoprotein), gene accession number (GeneBank accession No. ) NM_003128 (SPTBN1, Spectrin, beta, non-erythrocytic 1), gene accession number (GeneBank accession No. ) NM_002705 (PPL, Periplakin), gene accession number (GeneBank accession No. ) NM_002475 (MLC1SA, Myosin light chain 1 slow a), Gene accession number (GeneBank accession No. ) NM_002018 (FLII, Flightless I homolog (Drosophila)), Gene Accession Number (GeneBank accession No. ) NM_001465 (FYB, FYN binding protein (FYB-120 / 130)), gene registration number (GeneBank accession No. NM_001069 (TUBB2, Tubulin, beta 2A), gene accession number (GeneBank accession No. ) CR625172 (MGC8685, Tubulin, beta 2B), gene accession number (GeneBank accession No. CR616919 (KRT18, Keratin 18), gene accession number (GeneBank accession No. ) CR606241 (ACTG1, Actin, gamma 1), gene accession number (GeneBank accession No. ) CB240572 (MYH11, Myosin, heavy polypeptide 11, smooth muscle), gene accession number (GeneBank accession No. ) BX648253 (PTPN3, Protein tyrosine phosphatase, non-receptor type 3), Gene accession number (GeneBank accession No. ) BX648190 (WDR1, WD repeat domain 1), Gene accession number (GeneBank accession No. ) BX641076 (ACTN1, Actinin, alpha 1), gene accession number (GeneBank accession No. ) BX537978 (EPB41L1, Erythrocyte membrane protein band 4. 1-like 1), gene accession number (GeneBank accession No. ) BG121847 (NUDC, Nuclear distribution gene C homolog (A.  nidulans)), and GeneBank accession No. ) BC068013 (MYO1C, Myosin IC), gene accession number (GeneBank accession No. ) BC065499 (MAST2, Microtubule associated serine / threonine kinase 2), gene accession number (GeneBank accession No. ) BC051890 (TUBG2, Tubulin, gamma 2), gene accession number (GeneBank accession No. ) BC041874 (MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), gene accession number (GeneBank accession No. ) BC012597 (ACTA1, Actin, alpha 1, skeletal muscle), gene accession number (GeneBank accession No. ) AY484427 (KIF17, Kinesin family member 17), gene accession number (GeneBank accession No. ) AK130546 (STOML2, Stomatin (EPB72) -like 2), Gene accession number (GeneBank accession No. ) AK124711 (CORO2B, Coronin, actin binding protein, 2B), gene accession number (GeneBank accession No. ) AK123974 (MYL5, Myosin, light polypeptide 5, regulatory), gene accession number (GeneBank accession No. ) AK092792 (LOC389833, Similar to hypothetical protein MGC27019), gene accession number (GeneBank accession No. ) AK026518 (MYOHD1, Myosin head domain containing 1), gene accession number (GeneBank accession No. ) AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), gene accession number (GeneBank accession No. ) AF085886 (FLJ46675, Ribosomal protein L29 pseudogene 2), gene accession number (GeneBank accession No. ) AB209997 (MYO9B, Myosin IXB), gene accession number (GeneBank accession No. Y12692 (WNT11, Wingless-type MMTV integration site family, member 11), gene accession number (GeneBank accession No. ) Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), gene accession number (GeneBank accession No. X17033 (ITGA2, Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)), gene accession number (GeneBank accession No. ) U41763 (CLTCL1, Clathrin, heavy polypeptide-like 1), gene accession number (GeneBank accession No. NM_153609 (TMPRSS6, Transmembrane protease, serine 6), gene accession number (GeneBank accession No. ) NM_031483 (ITCH, Itchy homolog E3 ubiquitin protein ligase (mouse)), gene accession number (GeneBank accession No. ) NM_024342 (GRLF1, Glucocorticoid receptor DNA binding factor 1), gene accession number (GeneBank accession No. NM_017555 (EGLN2, Egl nine homolog 2 (C.  elegans), GeneBank accession No. NM_016569 (TBX3, T-box 3 (ulnar mammary syndrome)), gene accession number (GeneBank accession No. NM_004148 (NINJ1, Ninjurin 1), gene accession number (GeneBank accession No. ) NM_003377 (VEGFB, Vascular endothelial growth factor B), gene accession number (GeneBank accession No. ) NM_001983 (ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)), GeneBank accession No. ) NM_001552 (IGFBP4, Insulin-like growth factor binding protein 4), gene registration number (GeneBank accession No. ) NM_001430 (EPAS1, Endothelial PAS domain protein 1), Gene accession number (GeneBank accession No. NM_001300 (KLF6, Kruppel-like factor 6), gene accession number (GeneBank accession No. ) NM_001012661 (SLC3A2, Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), gene accession number (GeneBank accession No. NM_000596 (IGFBP1, Insulin-like growth factor binding protein 1), gene registration number (GeneBank accession No. ) NM_000474 (TWIST1, Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)), Gene Accession No. ) BX649103 (ChGn, Chondroitin beta1,4 N-acetylgalactosaminyltransferase), Gene Accession No. ) BM913048 (TIMP1, TIMP metallopeptidase inhibitor 1), gene accession number (GeneBank accession No. ) BM904612 (S100A6, S100 calcium binding protein A6 (calcyclin)), gene accession number (GeneBank accession No. ) BM556279 (EMP3, Epithelial membrane protein 3), gene accession number (GeneBank accession No. ) BC015041 (VAT1, Family with sequence similarity 82, member C), gene accession number (GeneBank accession No. ) AY258066 (OKL38, Pregnancy-induced growth inhibitor), gene accession number (GeneBank accession No. ) AK126729 (NDRG4, NDRG family member 4), gene accession number (GeneBank accession No. ) AK090459 (NFE2L1, Nuclear factor (erythroid-derived 2) -like 1), gene accession number (GeneBank accession No. ) AK074163 (ROBO4, Roundabout homolog 4, magic roundabout (Drosophila)), Gene accession number (GeneBank accession No. ) AK024680 (FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), gene accession number (GeneBank accession No. ) AF176422 (HEY1, Hairy / enhancer-of-split related with YRPW motif 1), gene accession number (GeneBank accession No. ) AF003837 (JAG1, Jagged 1 (Alagille syndrome)), gene accession number (GeneBank accession No. ) AB209322 (SEMA3B, Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B), GeneBank accession No. ) AB011150 (NRXN1, Neurexin 1), gene accession number (GeneBank accession No. ) NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)), gene accession number (GeneBank accession No. NM_052999 (CKLFSF1, CKLF-like MARVEL transmembrane domain containing 1), gene accession number (GeneBank accession No. NM_006644 (HSPH1, Heat shock 105kDa / 110kDa protein 1), gene registration number (GeneBank accession No. NM_005438 (FOSL1, FOS-like antigen 1), gene accession number (GeneBank accession No. ) NM_004996 (ABCC1, ATP-binding cassette, sub-family C (CFTR / MRP), member 1), gene registration number (GeneBank accession No. ) NM_002658 (PLAU, Plasminogen activator, urokinase), gene accession number (GeneBank accession No. ) NM_001353 (AKR1C1, Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha) -hydroxysteroid dehydrogenase)), gene accession number (GeneBank accession No. ) H18681 (C20orf139, Sulfiredoxin 1 homolog (S.  cerevisiae)), gene accession number (GeneBank accession No. ) DR004094 (HAMP, Hepcidin antimicrobial peptide), gene accession number (GeneBank accession No. ) BC082272 (KCNMB3, Potassium large conductance calcium-activated channel, subfamily M beta member 3), Gene Accession No. ) BC040494 (DNAJB2, DnaJ (Hsp40) homolog, subfamily B, member 2), gene accession number (GeneBank accession No. ) BC018064 (ATF6, Activating transcription factor 6), gene accession number (GeneBank accession No. ) BC006523 (SGK2, Serum / glucocorticoid regulated kinase 2), gene registration number (GeneBank accession No. ) AK090482 (CXCL12, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)), gene accession number (GeneBank accession No. ) AF219946 (TULP4, Tubby like protein 4), gene accession number (GeneBank accession No. ) AB209112 (SLC2A8, Solute carrier family 2, (facilitated glucose transporter) member 8), gene accession number (GeneBank accession No. ) NM_005242 (F2RL1, Coagulation factor II (thrombin) receptor-like 1), gene accession number (GeneBank accession No. ) NM_001002029 (C4A, Complement component 4B, telomeric), Gene accession number (GeneBank accession No. ) NM_000539 (RHO, Rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)), gene accession number (GeneBank accession No. ) BX649164 (PAI, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), gene registration number (GeneBank accession No. ) BM918324 (LY96, Lymphocyte antigen 96), gene accession number (GeneBank accession No. ) AB209647 (NCF2, Neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2)), gene accession number (GeneBank accession No. ) NM_152221 (CSNK1E, Casein kinase 1, epsilon), Gene accession number (GeneBank accession No. ) NM_017999 (RNF31, Ring finger protein 31), gene accession number (GeneBank accession No. ) NM_016819 (OGG1, 8-oxoguanine DNA glycosylase), gene accession number (GeneBank accession No. ) NM_016816 (OAS1, 2 ', 5'-oligoadenylate synthetase 1, 40 / 46kDa), Gene Accession No. NM_012235 (SCAP, SREBP cleavage-activating protein), gene accession number (GeneBank accession No. ) NM_006384 (CIB1, Calcium and integrin binding 1 (calmyrin)), gene accession number (GeneBank accession No. ) NM_001779 (CD58, CD58 antigen, (lymphocyte function-associated antigen 3)), gene accession number (GeneBank accession No. ) CB055213 (ICOSLG, Inducible T-cell co-stimulator ligand), Gene accession number (GeneBank accession No. ) BX641029 (MASP1, Mannan-binding lectin serine peptidase 1 (C4 / C2 activating component of Ra-reactive factor)), GeneBank accession No. ) BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), Gene Accession No. ) BC039299 (STIP1, Stress-induced-phosphoprotein 1 (Hsp70 / Hsp90-organizing protein)), gene accession number (GeneBank accession No. ) AY055760 (DAF, Decay accelerating factor for complement (CD55, Cromer blood group system)), gene accession number (GeneBank accession No. ) AK130188 (FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog), Gene Accession No. ) AK095326 (MUS81, MUS81 endonuclease homolog (yeast)), gene accession number (GeneBank accession No. NM_017670 (OTUB1, OTU domain, ubiquitin aldehyde binding 1), gene registration number (GeneBank accession No. ) NM_003004 (SECTM1, Secreted and transmembrane 1), gene accession number (GeneBank accession No. ) NM_002309 (LIF, Hypothetical protein MGC20647), gene accession number (GeneBank accession No. ) NM_001421 (ELF4, E74-like factor 4 (ets domain transcription factor)), gene accession number (GeneBank accession No. ) NM_000418 (IL4R, Interleukin 4 receptor), gene accession number (GeneBank accession No. ) BI909222 (FCER1G, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), gene accession number (GeneBank accession No. ) BF569086 (NK4, Interleukin 32), gene accession number (GeneBank accession No. ) BC014470 (AZGP1, Alpha-2-glycoprotein 1, zinc), gene accession number (GeneBank accession No. ) BC020744 (AKR1C4, Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol), dehydrogenase 4), gene accession number (GeneBank accession No. ) BQ939577 (AKR1C3, Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)), gene accession number (GeneBank accession No. ) NM_000499 (CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), gene accession number (GeneBank accession No. ) NM_030622 (CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), gene accession number (GeneBank accession No. ) NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate), gene accession number (GeneBank accession No. ) NM_024307 (MGC4171, Hypothetical protein LOC283901), gene accession number (GeneBank accession No. ) NM_005336 (HDLBP, High density lipoprotein binding protein (vigilin)), gene registration number (GeneBank accession No. NM_002627 (PFKP, Phosphofructokinase, platelet), Gene accession number (GeneBank accession No. ) BX648281 (LDLR, low density lipoprotein receptor (familial hypercholesterolemia)), gene accession number (GeneBank accession No. ) BC069201 (FLJ22761, Hexokinase domain containing 1), gene accession number (GeneBank accession No. ) BC030207 (NR0B2, Nuclear receptor subfamily 0, group B, member 2), gene accession number (GeneBank accession No. ) AL833069 (KIAA1434, Hypothetical protein KIAA1434), gene accession number (GeneBank accession No. ) AK124656 (ENO2, Enolase 2 (gamma, neuronal)), gene accession number (GeneBank accession No. ) AK094474 (RHOC, Ras homolog gene family, member C), gene accession number (GeneBank accession No. ) AK093461 (ISYNA1, Myo-inositol 1-phosphate synthase A1), gene accession number (GeneBank accession No. ) AB053232 (GAL3ST3, Galactose-3-O-sulfotransferase 3), gene accession number (GeneBank accession No. ) AB045292 (TMEM8, Transmembrane protein 8 (five membrane-spanning domains)), gene accession number (GeneBank accession No. ) NM_004753 (DHRS3, Dehydrogenase / reductase (SDR family) member 3), Gene accession number (GeneBank accession No. ) NM_002900 (RBP3, Retinol binding protein 3, interstitial), gene accession number (GeneBank accession No. ) NM_001995 (ACSL1, Acyl-CoA synthetase long-chain family member 1), gene accession number (GeneBank accession No. NM_000018 (ACADVL, Acyl-Coenzyme A dehydrogenase, very long chain), gene accession number (GeneBank accession No. ) BC094756 (CRA, Myotubularin related protein 11), gene accession number (GeneBank accession No. ) BC050553 (NTE, Neuropathy target esterase), gene accession number (GeneBank accession No. ) BC033110 (HSD17B1, Hydroxysteroid (17-beta) dehydrogenase 1), Gene accession number (GeneBank accession No. ) AY268890 (TPP1, Tripeptidyl peptidase I), gene accession number (GeneBank accession No. ) AK172798 (CPT1A, Carnitine palmitoyltransferase 1A (liver)), gene accession number (GeneBank accession No. ) AK096809 (CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), gene accession number (GeneBank accession No. ) AK000600 (SIAT7D, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) -N-acetylgalactosaminide alpha-2,6-sialyltransferase 4), Gene accession number ) AB002454 (CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), gene accession number (GeneBank accession No. ) Z29093 (DDR1, Discoidin domain receptor family, member 1), gene accession number (GeneBank accession No. ) Z25424 (MKNK2, MAP kinase interacting serine / threonine kinase 2), gene accession number (GeneBank accession No. ) XM_291277 (DKFZp761P0423, Hypothetical protein DKFZp761P0423), gene accession number (GeneBank accession No. XM_038150 (MAST3, Microtubule associated serine / threonine kinase 3), gene accession number (GeneBank accession No. ) U88357 (ERBB3, V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)), gene accession number (GeneBank accession No. ) NM_025195 (TRIB1, Tribbles homolog 1 (Drosophila)), gene accession number (GeneBank accession No. NM_020639 (RIPK4, Receptor-interacting serine-threonine kinase 4), gene accession number (GeneBank accession No. ) NM_014172 (PHPT1, Phosphohistidine phosphatase 1), Gene accession number (GeneBank accession No. ) NM_006254 (PRKCD, Protein kinase C, delta), Gene accession number (GeneBank accession No. ) NM_005415 (SLC20A1, Solute carrier family 20 (phosphate transporter), member 1), gene accession number (GeneBank accession No. ) NM_005026 (PIK3CD, Phosphoinositide-3-kinase, catalytic, delta polypeptide), Gene accession number (GeneBank accession No. ) NM_004431 (EPHA2, EPH receptor A2), gene accession number (GeneBank accession No. ) NM_004419 (DUSP5, Dual specificity phosphatase 5), gene accession number (GeneBank accession No. ) NM_004327 (BCR, Breakpoint cluster region), Gene accession number (GeneBank accession No. ) NM_004231 (ATP6V1F, ATPase, H + transporting, lysosomal 14kDa, V1 subunit F), gene registration number (GeneBank accession No. ) NM_004090 (DUSP3, Dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)), gene accession number (GeneBank accession No. ) NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), gene accession number (GeneBank accession No. NM_002496 (NDUFS8, NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase)), gene accession number (GeneBank accession No. NM_001001852 (PIM3, Pim-3 oncogene), gene accession number (GeneBank accession No. ) L76191 (IRAK1, Interleukin-1 receptor-associated kinase 1), gene accession number (GeneBank accession No. ) D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), gene accession number (GeneBank accession No. ) BC065207 (ATP6V0D2, ATPase, H + transporting, lysosomal 38kDa, V0 subunit d isoform 2), gene accession number (GeneBank accession No. ) BC035578 (STK24, Serine / threonine kinase 24 (STE20 homolog, yeast)), gene accession number (GeneBank accession No. ) BC028724 (DUSP18, Dual specificity phosphatase 18), gene accession number (GeneBank accession No. AL117482 (ULK3, Unc-51-like kinase 3 (C.  elegans), GeneBank accession No. ) AK126879 (PCTK3, PCTAIRE protein kinase 3), gene accession number (GeneBank accession No. ) AB209416 (ILK, Integrin-linked kinase-2), gene accession number (GeneBank accession No. ) NM_000782 (CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1), gene accession number (GeneBank accession No. ) CR597101 (ZFP36, Zinc finger protein 36, C3H type, homolog (mouse)), Gene accession number (GeneBank accession No. ) CR936799 (FHL2, Four and a half LIM domains 2), gene accession number (GeneBank accession No. ) M24898 (NR1D1, Nuclear receptor subfamily 1, group D, member 1), gene accession number (GeneBank accession No. ) AF132818 (KLF5, Kruppel-like factor 5 (intestinal)), gene accession number (GeneBank accession No. ) AK055337 (ZNF213, Zinc finger protein 213), Gene accession number (GeneBank accession No. ) BC008834 (PHF1, PHD finger protein 1), gene accession number (GeneBank accession No. ) AK126918 (GLIS2, GLIS family zinc finger 2), Gene accession number (GeneBank accession No. ) BC042692 (CTL2, Solute carrier family 44, member 2), gene accession number (GeneBank accession No. ) NM_002224 (ITPR3, Inositol 1,4,5-triphosphate receptor, type 3), gene accession number (GeneBank accession No. ) AK095363 (AQP3, Aquaporin 3), gene accession number (GeneBank accession No. NM_174953 (ATP2A3, ATPase, Ca ++ transporting, ubiquitous), gene accession number (GeneBank accession No. ) BC042390 (VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B (yeast)), GeneBank Accession No. NM_016113 (TRPV2, Transient receptor potential cation channel, subfamily V, member 2), gene accession number (GeneBank accession No. ) BM926478 (RBP1, Retinol binding protein 1, cellular), gene accession number (GeneBank accession No. NM_000069 (CACNA1S, Calcium channel, voltage-dependent, L type, alpha 1S subunit), Gene Registration Number (GeneBank accession No. ) AK002107 (RAB3B, RAB3B, member RAS oncogene family), gene accession number (GeneBank accession No. ) NM_013321 (SNX8, Sorting nexin 8), Gene accession number (GeneBank accession No. ) AK125026 (SLC6A12, Solute carrier family 6 (neurotransmitter transporter, betaine / GABA), member 12), gene accession number (GeneBank accession No. ) NM_005843 (STAM2, Signal transducing adapter molecule (SH3 domain and ITAM motif) 2), gene accession number (GeneBank accession No. ) AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), gene accession number (GeneBank accession No. ) U49248 (ABCC2, ATP-binding cassette, sub-family C (CFTR / MRP), member 2), gene accession number (GeneBank accession No. ) AK172792 (SCNN1A, Sodium channel, nonvoltage-gated 1 alpha), gene accession number (GeneBank accession No. ) BC044656 (CASC3, Cancer susceptibility candidate 3), gene accession number (GeneBank accession No. NM_203403 (C9orf150, Chromosome 9 open reading frame 150), gene accession number (GeneBank accession No. NM_080388 (S100A16, S100 calcium binding protein A16), gene registration number (GeneBank accession No. NM_031286 (SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), gene accession number (GeneBank accession No. NM_022153 (PP2135, Chromosome 10 open reading frame 54), gene accession number (GeneBank accession No. ) NM_004864 (GDF15, Growth differentiation factor 15), Gene accession number (GeneBank accession No. ) NM_003330 (TXNRD1, Thioredoxin reductase 1), gene accession number (GeneBank accession No. ) NM_001013632 (LOC343521, Similar to hypothetical protein 4833401D15), gene accession number (GeneBank accession No. ) BX537968 (LOC51149, Hypothetical LOC51149), gene accession number (GeneBank accession No. BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), gene accession number (GeneBank accession No. ) BQ683841 (S100A11, S100 calcium binding protein A11 (calgizzarin)), gene accession number (GeneBank accession No. ) BQ276852 (TMSB10, Thymosin, beta 10), gene accession number (GeneBank accession No. ) AK126182 (KIAA1949, KIAA1949), gene accession number (GeneBank accession No. ) AK124751 (CAPN2, Calpain 2, (m / II) large subunit), gene accession number (GeneBank accession No. ) AK095079 (RGC32, Response gene to complement 32), gene accession number (GeneBank accession No. ) AB075871 (FLJ42654, Golgi transport 1 homolog A (S.  cerevisiae)).

2) Among the biomarkers, biomarker genes whose expression is reduced by exposure of phenanthrene are as follows:

GeneBank accession No.AK125150 (MAPK8, Mitogen-activated protein kinase 8), GeneBank accession No. NM_002758 (MAP2K6, Mitogen-activated protein kinase kinase 6), Gene accession number (GeneBank accession No.) NM_004612 (TGFBR1, Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kDa)), gene accession number (GeneBank accession No.) NM_145686 (MAP4K4, Mitogen-activated protein kinase kinase kinase 4) , GeneBank accession No. XM_042066 (MAP3K1, Mitogen-activated protein kinase kinase kinase 1), GeneBank accession No. AB011123 (TNIK, TRAF2 and NCK interacting kinase), Gene accession number (GeneBank accession No.) AB209031 (C5, Complement component 5), GeneBank accession No. NM_022740 (HIPK2, Homeodomain interacting protein kinase 2), GeneBank accession No. NM_148957 (TNFRSF19, Tumor necrosis factor receptor superf amily, member 19), GeneBank accession No. AB208909 (ITGB2, Integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1); macrophage antigen 1 (mac-1) beta subunit)), GeneBank accession No. AB209211 (TIA1, TIA1 cytotoxic granule-associated RNA binding protein), GeneBank accession No. AB209613 (DNASE1L3, Deoxyribonuclease) I-like 3), GeneBank accession No. AK122825 (HMGB1, High-mobility group box 1), GeneBank accession No. AK127326 (PHF17, PHD finger protein 17), Gene accession number ( GeneBank accession No.) AK223503 (CASP1, Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)), GeneBank accession No. BC013326 (GAS2, Growth arrest-specific 2), gene registration number GeneBank accession No. BC047698 (IL7, Interleukin 7), GeneBank accession No. D79987 (ESPL1, Extra spindle poles like 1 (S. cerevisiae)), GeneBank accession No. NM_000893 ( KNG1, Kininogen 1), GeneBank accession No. NM_001012271 (BIRC5, Effe ctor cell peptidase receptor 1), GeneBank accession No. NM_004938 (DAPK1, Death-associated protein kinase 1), GeneBank accession No. NM_005879 (TRIP, TRAF interacting protein), gene registration number (GeneBank accession No.) NM_014739 (BCLAF1, BCL2-associated transcription factor 1), gene accession number (GeneBank accession No.) NM_018947 (CYCS, Cytochrome c, somatic), gene accession number (GeneBank accession No.) AB033337 (MPHOSPH1, M-phase phosphoprotein 1), GeneBank accession No. AB209179 (PLK1, Polo-like kinase 1 (Drosophila)), Gene accession number (GeneBank accession No.) AB209337 (CDC7, CDC7 cell division cycle 7 (S . cerevisiae)), GeneBank accession No. AF053305 (BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)), GeneBank accession No. AF053306 (BUB1B, BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast), GeneBank accession No. AF345347 (SPAG5, Sperm associated antigen 5), GeneBank accession No. AK092638 (CCNG2, Cyclin G2), GeneBank accession No. AK222819 (NUSAP1, Nucleolar and spindle associated protein 1), GeneBank accession No. AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1 (yeast)), GeneBank accession No. AY257469 ( CIT, Citron (rho-interacting, serine / threonine kinase 21), GeneBank accession No. AY367065 (ASPM, Asp (abnormal spindle) -like, microcephaly associated (Drosophila)), GeneBank accession No.) BC011000 (CDCA5, Cell division cycle asso ciated 5), GeneBank accession No. BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No. BC043502 (NEK2, never in mitosis gene a) -related kinase 2 , GeneBank accession No. BU675073 (PTTG1, Pituitary tumor-transforming 1), GeneBank accession No. BX647885 (STMN1, Stathmin 1 / oncoprotein 18), GeneBank accession No. CR592757 (BRRN1, Barren homolog 1 (Drosophila)), GeneBank accession No. CR597075 (MAPRE2, Microtubule-associated protein, RP / EB family, member 2), GeneBank accession No. CR604810 ( CCNA2, Cyclin A2), GeneBank accession No. CR933728 (CDC2, Cell division cycle 2, G1 to S and G2 to M), GeneBank accession No. NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase), GeneBank accession No. NM_001790 (CDC25C, Cell division cycle 2 5C), GeneBank accession No. NM_001798 (CDK2, Cyclin-dependent kinase 2), GeneBank accession No. NM_001813 (CENPE, Centromere protein E, 312kDa), GeneBank accession No. NM_003318 (TTK, TTK protein kinase), GeneBank accession No. NM_003981 (PRC1, Protein regulator of cytokinesis 1), GeneBank accession No. NM_004523 (KIF11, Kinesin family member 11) Gene accession number (GeneBank accession No.) NM_004701 (CCNB2, Cyclin B2), gene accession number (GeneBank accession No.) NM_005983 (SKP2, S-phase kinase-associated protein 2 (p45)), gene accession number (GeneBank accession No. NM_006101 (KNTC2, Kinetochore associated 2), GeneBank accession No. NM_006845 (KIF2C, Kinesin family member 2C), GeneBank accession No. NM_007375 (TARDBP, TAR DNA binding protein), Gene Registration number (GeneBank accession No.) NM_012112 (TPX2, TPX2, microtubul e-associated, homolog (Xenopus laevis)), GeneBank accession No. NM_014750 (DLG7, Discs, large homolog 7 (Drosophila)), GeneBank accession No. NM_015097 (CLASP2, Cytoplasmic linker associated protein 2), GeneBank accession No. NM_016343 (CENPF, Centromere protein F, 350 / 400ka (mitosin)), GeneBank accession No. NM_016426 (GTSE1, G-2 and S-phase expressed 1), Gene Registration Number (GeneBank accession No.) NM_018492 (PBK, PDZ binding kinase), Gene Registration Number (GeneBank accession No.) NM_018685 (ANLN, Anillin, actin binding protein (scraps homolog, Drosophila)), Gene Registration Number GeneBank accession No. NM_020242 (KNSL7, Kinesin family member 15), GeneBank accession No. NM_031966 (CCNB1, Cyclin B1), GeneBank accession No. NM_138555 (KIF23, Kinesin family member 23 ), GeneBank accession No. U65410 (MAD2L1, MAD2 mitotic arrest defic ient-like 1 (yeast), GeneBank accession No. AB020656 (CYLD, Cylindromatosis (turban tumor syndrome)), GeneBank accession No. AF033122 (SESN1, Sestrin 1), Gene registration GeneBank accession No. AK074377 (UHRF1, Chromosome 19 open reading frame 31), GeneBank accession No. AK091170 (CDKN2C, Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)), gene registration number ( GeneBank accession No.) AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No. AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), Gene accession number (GeneBank accession No.) BC033086 (TCF19, Transcription factor 19 (SC1)), GeneBank accession No. BC040303 (PTP4A1, Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No. BC040991 (TFDP2 , Transcription factor Dp-2 (E2F dimerization partner 2), gene registration number (GeneBank accession No.) BC092412 (SGOL2, Shugoshin-like 2 (S. pombe), GeneBank accession No. BQ278454 (CKS1B, CDC28 protein kinase regulatory subunit 1B), GeneBank accession No. BX649128 (SESN3, Sestrin 3), GeneBank accession No. ) CD049340 (AURKB, Aurora kinase B), GeneBank accession No. M89914 (NF1, Neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)), GeneBank accession No. NM_001005414 (ZWINT, ZW10 interactor antisense, GeneBank accession No. NM_001008491 (Sep 2, Septin 2), GeneBank accession No. NM_001274 (CHEK1, CHK1 checkpoint homolog (S. pombe)), Gene accession number ( GeneBank accession No.) NM_002105 (H2AFX, H2A histone family, member X), GeneBank accession No.) NM_002388 (MCM3, MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)), Gene accession number (GeneBank accession No. NM_002417 (MKI67, Antigen identified by monoclon al antibody Ki-67), GeneBank accession No. NM_002875 (RAD51, RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)), GeneBank accession No. NM_003884 (PCAF, P300 / CBP-associated factor), GeneBank accession No. NM_004526 (MCM2, MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)), GeneBank accession No. NM_004847 (AIF1, Allograft inflammatory factor 1), GeneBank accession No. NM_005915 (MCM6, MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) ( S. cerevisiae)), GeneBank accession No. NM_012090 (MACF1, Microtubule-actin crosslinking factor 1), GeneBank accession No. NM_012415 (RAD54B, RAD54 homolog B (S. cerevisiae)), GeneBank accession No. NM_014264 (PLK4, Polo-like kinase 4 (Drosophila)), GeneBank accession No. NM_015714 (G0S2, G0 / G1switch 2), GeneBank accession No. ) NM_024680 (FLJ23311, E2F transcription factor 8), GeneBank accession No. XM_034274 (MYBL1, V-myb myeloblastosis viral oncogene homolog (avian) -like 1), Gene accession number (GeneBank accession No.) AK001720 ( FLJ10858, Nei endonuclease VIII-like 3 (E. coli)), gene registration number (GeneBank acc ession No.) AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No. BC034480 (BLM, Bloom syndrome), GeneBank accession No. BC073161 (RAD51C, RAD51 homolog C (S. cerevisiae)), GeneBank accession No. CR600021 (HMGB2, High-mobility group box 2), GeneBank accession No. CR625391 (RAD51AP1, RAD51 associated protein 1), GeneBank accession No.) CR936783 (FLJ40869, Hypothetical protein LOC284952), GeneBank accession No. DQ140356 (KIAA1596, Fanconi anemia, complementation group M), GeneBank accession No. NM_001067 (TOP2A, Topoisomerase (DNA) II alpha 170kDa), GeneBank accession No. NM_001618 (PARP1, Poly (ADP-ribose) polymerase family, member 1), GeneBank accession No. NM_003362 (UNG, Uracil-DNA glycosylase), GeneBank accession No. NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No. NM_130398 (EXO1, Exonuclease 1), GeneBank accession No. AB020807 (TLR6, Toll-like receptor 6), gene GeneBank accession No. AB032980 (DCDC2, Doublecortin domain containing 2), GeneBank accession No. AB209866 (TFPI, Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor), GeneBank accession No.) AK057015 (HSPA4, Heat shock 70kDa protein 4), GeneBank accession No. AK095515 (IFIT1, Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No. AK122686 (IF , I factor (complement), GeneBank accession No. AK123010 (RRM2, Ribonucleotide reductase M2 polypeptide), GeneBank accession No. BC035582 (TRIM22, Tripartite motif-containing 22) GeneBank accession No. BX537894 (LOC493869, Similar to RIKEN cDNA 2310016C16), GeneBank accession No. M14338 (PROS1, Protein S (alpha)), GeneBank accession No. NM_000821 (GGCX, Gamma-glutamyl carboxyla se), GeneBank accession No. NM_000963 (PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G / H synthase and cyclooxygenase)), GeneBank accession No. NM_001001547 (CD36, CD36 antigen (collagen type) I receptor, thrombospondin receptor), GeneBank accession No. NM_001512 (GSTA4, Glutathione S-transferase A4), GeneBank accession No. NM_001629 (ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), GeneBank accession No. NM_001752 (CAT, Catalase), GeneBank accession No. NM_001837 (CCR3, Chemokine (CC motif) receptor 3), GeneBank accession No. NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No. NM_001994 (F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No. NM_002182 (IL1RAP, Interleukin 1 receptor accessory protein), gene Registration number GeneBank accession No. NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No. NM_173216 (SIAT1, ST6 beta-galactosamide alpha-2,6-sylyltranferase 1), GeneBank accession No. NM_202002 (FOXM1, Forkhead box M1), GeneBank accession No. AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase), GeneBank accession No. BC027881 (AFP) , Alpha-fetoprotein, GeneBank accession No. NM_015915 (SPG3A, Spastic paraplegia 3A (autosomal dominant)), GeneBank accession No. NM_000671 (ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), GeneBank accession No. J05428 (UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), GeneBank accession No. NM_000672 (ADH6, Alcohol dehydrogenase 6 (class V)), gene registration number (GeneBank accession No.) M15943 (ADH4, Alcohol dehy drogenase 4 (class II), pi polypeptide), gene accession number (GeneBank accession No.) AK223395 (FBP1, Fructose-1,6-bisphosphatase 1), gene accession number (GeneBank accession No.) NM_000151 (G6PC, Glucose-6 -phosphatase, catalytic (glycogen storage disease type I, von Gierke disease), GeneBank accession No. XM_113962 (KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No. AB020644 (ACSL6, Acyl-CoA synthetase long-chain family member 6), GeneBank accession No. AB209907 (PLD1, Phospholipase D1, phophatidylcholine-specific), GeneBank accession No. AF285167 (ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1), GeneBank accession No. AF297872 (TRERF1, Transcriptional regulating factor 1), GeneBank accession No. AF303134 (ALDH8A1, Aldehyde) dehydrogenase 8 family, member A1), gene registration number GeneBank accession No.AF339053 (PLA2G12B, Phospholipase A2, group XIIB), GeneBank accession No.AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), Gene accession number (GeneBank accession No.) AK124635 (PCSK9, Proprotein convertase subtilisin / kexin type 9), GeneBank accession No. AK127346 (SIAT9, ST3 beta-galactoside alpha-2,3-sialyltransferase 5), GeneBank accession No. AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No. AY691170 (PLCL3, Phospholipase C-like 3), GeneBank accession No. BG567934 (APOM, Apolipoprotein M), Gene Registration Number (GeneBank accession No.) BX538214 (C6orf167, Chromosome 6 open reading frame 167), GeneBank accession No. BX640945 (FADS2, Fatty acid desaturase 2), GeneBank accession No. BX648473 (PIGK , Phosphatidylinositol glycan, class K), gene registration GeneBank accession No. BX648557 (HSD17B2, Hydroxysteroid (17-beta) dehydrogenase 2), GeneBank accession No. CR749601 (ETNK1, Death-associated protein kinase 3), Gene accession No. ) NM_000859 (HMGCR, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase), GeneBank accession No. NM_001443 (FABP1, Fatty acid binding protein 1, liver), GeneBank accession No. NM_002130 (HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble), GeneBank accession No.) NM_003725 (RODH, Hydroxysteroid (17-beta) dehydrogenase 6), Gene accession number (GeneBank accession No NM_004845 (PCYT1B, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No. NM_014762 (DHCR24, 24-dehydrocholesterol reductase), GeneBank accession No. NM_020139 (DHRS6ductase) (SDR family) member 6), GeneBank accessi on No.) NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No. NM_032523 (OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No. NM_033505 ( SELI, Selenoprotein I), GeneBank accession No. Z28339 (AKR1D1, Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)), GeneBank accession No.) AK024899 (ENPP3, Ectonucleotide pyrophosphatase / phosphodiesterase 3), GeneBank accession No. AK025546 (PTPN4, Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)), Gene accession number (GeneBank accession No.) AK124910 (ENPP2, Ectonucleotide pyrophosphatase / phosphodiesterase 2 (autotaxin)), gene accession number (GeneBank accession No.) BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538), gene accession number (GeneBank accession No.) BC050565 (PASK, PAS domain containing serine / threonine kinase), GeneBank accession No. L13436 (NPR2, Natriuretic peptide receptor B / guanylate cyclase B (atrionatriuretic peptide receptor B)), GeneBank accession No. NM_001005862 (ERBB2, V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro / glioblastoma derived oncogene homolog (avian), GeneBank accession No. NM_005012 (ROR1, Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No. NM_006035 (CDC42BPB , CDC42 binding protein kinase beta (DMPK-like), GeneBank accession No. NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No. NM_023028 (FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No. NM_080836 (STK35, Serine / threonine kinase 35), GeneBank accession No. AF419331 (FUSIP1, FUS interacting protein (serine / arginine-rich) 1), GeneBank accession No. AK091927 (SFRS3, Splicing factor, arginine / serine-rich) 3), GeneBank accession No. BC010266 (HNRNPA1, Heterogeneous nuclear ribonucleoprotein A1), GeneBank accession No. BC012360 (CTAGE5, CTAGE family, member 5), GeneBank accession No. ) BC036046 (PLRG1, Pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)), GeneBank accession No. BC065384 (PCF11, PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)), GeneBank accession No. BX537360 (CPSF5, Nudix (nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No. BX537494 (HNRPA2B1, Heterogeneous nuclear ribonucleoprotein A2 / B1 GeneBank accession No. BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No. CA455267 (PPIH, Peptidyl prolyl isomerase H (cyclophilin H), GeneBank accession No.) CR596214 (HNRPA0, Heterogeneous nuclear ribonucleoprotein A0), GeneBank accession No. NM_001326 (CSTF3, Hypothetical protein LOC283267), GeneBank accession No. NM_004640 (BAT1, HLA-B associated transcript 1 GeneBank accession No. NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No. NM_006924 (SFRS1, Splicing factor, arginine / serine-rich 1 (splicing fact) or 2, alternate splicing factor), GeneBank accession No. NM_012426 (SF3B3, Splicing factor 3b, subunit 3, 130 kDa), GeneBank accession No. NM_018048 (FLJ10292, Mago-nashi homolog) , GeneBank accession No. NM_030919 (C20orf129, Chromosome 20 open reading frame 129), GeneBank accession No. NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) GeneBank accession No. NM_138933 (ACF, Apobec-1 complementation factor), GeneBank accession No. AB193259 (ACE2, Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2), gene GeneBank accession No. BX648769 (EWSR1, Ewing sarcoma breakpoint region 1), GeneBank accession No. AB023154 (DTX4, Deltex 4 homolog (Drosophila)), GeneBank accession No. AL543755 (VAV3, Vav 3 oncogene), gene registration number ( GeneBank accession No.) M75106 (CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), gene accession number (GeneBank accession No.) NM_021045 (ZNF248, Zinc finger protein 248), gene accession number (GeneBank accession No.) AB209194 (B4GALT6 , UDP-Gal: betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6), gene accession number (GeneBank accession No.) AF279145 (ANTXR1, Anthrax toxin receptor 1), gene accession number (GeneBank accession No.) NM_025074 (FRAS1, Fraser syndrome 1), GeneBank accession No.AK025790 (KIF20A, Kinesin family member 20A), GeneBank accession No. NM_006152 (LRMP, Lymphoid-restricted membrane protein), GeneBank accession No.) NM_000340 (SLC2A2, Solute carrier family 2 (facilitated glucose transporter), member 2), GeneBank accession No. AF071592 (KIF4A, Kinesin family member 4A), Gene accession number (GeneBank accession No.) NM_013277 (RACGAP1, Rac GTPase activating protein 1), GeneBank accession No. AY043484 (SCN1A, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No. AY791349 (KIF18A, Kinesin family member 18A), gene registration Number (GeneBank accession No.) NM_018018 (SLC38A4, Solute carrier family 38, member 4), GeneBank accession No. AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590.), GeneBank accession No. NM_021069 (ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No. NM_001005747 (CACNB4, Calcium channel, voltage- dependent, beta 4 subunit), GeneBank accession No. AJ496568 (SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No. NM_030641 (APOL6, Apolipoprotein L , 6), GeneBank accession No. NM_173512 (FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No. NM_000037 (ANK1, Ankyrin 1, erythrocytic), Gene accession number (GeneBank accession No.) NM_001011554 (SLC13A3, Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3), gene accession number (GeneBank accession No.) AB091343 (C10orf3, Centrosomal protein 55kDa), gene accession number (GeneBank accession No.) AK000643 (ASB9 , Ankyrin repeat and SOCS box-containing 9), GeneBank accession No. AK055221 (FBXO5, F-box protein 5), GeneBank accession No. AK075271 (SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2 -like (aminotransferase 2)), gene accession number (GeneBank accession No.) AK122685 (GLUD1, Glutamate dehydrogenase 1), gene accession number (GeneBank accession No.) AK127098 (FLJ10706, Chromosome 1 open reading frame 112), gene accession number GeneBank accession No.AL133031 (MLR1, Transcription factor MLR1), GeneBank accession No. AY007723 (MAL2, Mal, T-cell differentiation protein 2), GeneBank accession No. BC022255 (Spc25 Spindle pole body component 25 homolog (S. cerevisiae)), GeneBank accession No. BC041882 (ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No. BC052951 (LMNB1, Lamin B1), Gene accession No. BC098313 (FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No. NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No. NM_145061 (C13orf3, Chromosome 13 open reading frame 3 GeneBank accession No. XM_372695 (LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859), mRNA).

The present inventors confirmed the cytotoxicity by treating phenanthrene to human liver cancer cell line (HepG2) in order to discover a biomarker for confirming the exposure to phenanthrene. As a result, the phenanthrene was confirmed to be toxic to human liver cancer cell line (see FIG. 1), and the concentration of phenanthrene was determined based on the experiment. Thereafter, phenanthrene was treated to human liver cancer cell lines at the determined concentration, mRNA was isolated from the cell line treated with the substance, and cDNA was synthesized and labeled with fluorescent substance (Cy5), and the control group not treated with drug was labeled with Cy3. It was. The fluorescently labeled cDNA was hybridized with a 44 k oligomicroarray chip, Human whole genome microarray (Agilent, USA), and analyzed for differences in gene expression patterns by scanning fluorescent images (see FIG. 2). In the analysis, when the Cy5 / Cy3 ratio was 2.0 times or more, the expression was increased. As a result, it was confirmed that the gene with increased expression was 0.69% (302 of 44,000 genes) and 0.55% (244 of 44,000 genes) with reduced expression. In this case, when the genes that are overexpressed or underexpressed by phenanthrene are classified by the function classified, MAPKinase Signaling Pathway, MAPKKK cascade, apoptosis, and mitotic cell cycle (Mitotic cell cycle), cell cycle, cell differentiation, cell motility, cytoskeleton, morphogenesis, response to DNA damage stimulus, Response to chemical stimulus, Response to external stimulus, Response to stress, Immune response, Metabolism of cytochrome p450 xenobiotics by cytochrome p450), alcohol metabolism, lipid metabolism, phosphate metabolism, DNA metabolism, metal binding or transport It was in the genes (see Table 2 and Table 3). The genes are not reported to be associated with toxicity in human liver cancer cells when treated with phenanthrene used in the present invention.

The present inventors separated the overexpressed genes and the nine low-expressed genes from the genes and examined the expression patterns by real-time reverse transcript polymerase chain reaction (RT-PCR). As a result, it was confirmed that the expression patterns of 19 overexpression genes and 9 low expression genes were similar to those of the oligomicroarray chip (see Table 5). These genes include the GeneBank accession No. BM913048 (TIMP metallopeptidase inhibitor 1), the GeneBank accession No. BX649164 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) , GeneBank accession No. NM_004864 (Growth differentiation factor 15), GeneBank accession No. NM_000499 (Cytochrome P450, family 1, subfamily A, polypeptide 1), Gene accession number (GeneBank accession No.) AK095363 (Aquaporin 3), GeneBank accession No. NM_001013632 (Similar to hypothetical protein 4833401D15), GeneBank accession No. BC042390 (Vesicle transport through interaction with t-SNAREs homolog 1B (yeast) ), GeneBank accession No. BQ683841 (S100 calcium binding protein A11 (calgizzarin)), GeneBank accession No. NM_003897 (Immediate early response 3), Gene accession number (GeneBank acc ession No.) BM926478 (Retinol binding protein 1, cellular), GeneBank accession No. BU945318 (metallothionein 2A), GeneBank accession No. AK094474 (Ras homolog gene family, member C), gene GeneBank accession No. Y11307 (Cysteine-rich, angiogenic inducer, 61), GeneBank accession No. AY247738 (Tribbles homolog 3 (Drosophila)), GeneBank accession No. Z25424 (GeneBank accession No.) MAP kinase interacting serine / threonine kinase 2), GeneBank accession No. NM_001769 (CD9 antigen (p24)), GeneBank accession No. Y12692 (Wingless-type MMTV integration site family, member 11) , GeneBank accession No. X02812 (Transforming growth factor, beta 1 (Camurati-Engelmann disease)), GeneBank accession No. NM_000596 (Insulin-like growth factor binding protein 1), Gene accession number (GeneBank accession No.) NM_006101 (Kinetochore assoc iated 2), GeneBank accession No. NM_003318 (TTK protein kinase), GeneBank accession No. NM_001067 (Topoisomerase (DNA) II alpha 170kDa), GeneBank accession No. NM_018492 (PDZ binding kinase), GeneBank accession No. U65410 (MAD2 mitotic arrest deficient-like 1 (yeast)), GeneBank accession No. AK074377 (Chromosome 19 open reading frame 31), Gene registration Number (GeneBank accession No.) CR600021 (High-mobility group box 2), GeneBank accession No. BC022255 (Spindle pole body component 25 homolog (S. cerevisiae)), GeneBank accession No. AB091343 (Centrosomal protein 55 kDa).

In another aspect, the present invention provides a DNA microarray chip for confirming the exposure to phenanthrene in which an oligonucleotide comprising all or part of the biomarker gene sequence or its complementary oligonucleotide is integrated.

The oligonucleotide or its complementary oligonucleotide comprises 18 to 30 nucleic acids of the biomarker gene, preferably 20 to 25 nucleic acids.

The phenanthrene retrieval DNA microarray chip of the present invention can be produced by a method known to those skilled in the art. The method of manufacturing the microarray chip is as follows. In order to immobilize the searched biomarker as a probe DNA molecule on a substrate of a DNA chip, a micropipetting method or a pin-shaped spotter using a piezoelectric method is used. It is preferable to use the method, but the present invention is not limited thereto. In a preferred embodiment of the present invention, a microarray, which is a pin-shaped spotter, is used. The substrate of the DNA microarray chip is preferably coated with one active group selected from the group consisting of amino-silane, poly-L-lysine, and aldehyde. It is not limited. In addition, the substrate may be selected from the group consisting of slide glass, plastic, metal, silicon, nylon membrane, and nitrocellulose membrane, but is not limited thereto, and in the preferred embodiment of the present invention, amino-silane may be used. Coated slide glass was used.

In addition, the present invention provides a method for checking the exposure to phenanthrene using the biomarker.

Specifically, the present invention

1) separating RNA from test subject-derived human somatic cells and control somatic cells;

2) labeling the experimental group and the control group with different fluorescent substances while synthesizing RNA of the experimental group and the control group of step 1) with cDNA;

3) hybridizing cDNA labeled with different fluorescent materials of step 2) with the DNA microarray chip;

4) analyzing the reacted DNA microarray chip of step 3); And

5) provides a method of detecting the biomarker of the present invention to determine whether the exposure to phenanthrene, including the step of confirming the expression level of the biomarker of the present invention in the analyzed data of step 4) compared to the control group do.

In the above method, the somatic cell of step 1) preferably uses human liver cancer cell line (HepG2), but is not limited thereto, and any cell derived from cells and tissues of human liver or liver cancer may be used.

In the method, the fluorescent material of step 3) is preferably selected from the group consisting of Cy3, Cy5, poly L-lysine-fluorescein isothiocyanate (FITC), rhodamine-B-isothiocyanate (RITC), and rhodamine (rhodamine). One is not limited thereto, and any fluorescent material known to those skilled in the art may be used.

In the above method, the DNA microarray chip of step 5) preferably uses Whole Human Genome Oligo Microarray (Agilent, USA) and the like, but is not limited thereto. Any microarray chip loaded with genes (see Tables 2 and 3) can be used, and it is most preferable to use a DNA microarray chip produced by the present inventors. In addition, the analysis method of step 5) preferably uses GenePix 4.1 software (Axon Instruments, USA), but is not limited thereto, and analysis software known to those skilled in the art may be used.

In addition, the present invention

1) separating RNA from test subject-derived human somatic cells and control somatic cells;

2) performing real-time reverse transcript polymerase chain reaction (RT-PCR) on the RNA of step 1) using a primer pair capable of amplifying the biomarker gene of the present invention; And

3) provides a method of detecting the biomarker of the present invention to determine whether the exposure to phenanthrene, including the step of comparing the gene product of step 2) with the control to confirm the expression level.

In the above method, the somatic cell of step 1) preferably uses human liver cancer cell line (HepG2), but is not limited thereto, and any cell derived from cells and tissues of human liver or liver cancer may be used.

In the above method, the primer of step 3) is complementary to the biomarker gene found in the present invention, and any primer that can amplify the biomarker can be used. In the present invention, 28 pairs of the forward and reverse primers set forth in SEQ ID NOs: 1 to 56 are provided, but the present invention is not limited thereto.

The present invention also provides a kit for confirming exposure to phenanthrene.

The present invention provides a kit for confirming exposure to phenanthrene, including the DNA microarray chip prepared in the present invention.

In addition to the identification kit provides a kit for confirming the exposure to phenanthrene containing human hepatocytes. The human hepatocyte is preferably HepG2, but is not limited thereto. Any human hepatocyte may be used as long as it is derived from cells and tissues of human liver or liver cancer.

The kit may further include a fluorescent material, wherein the fluorescent material is selected from the group consisting of a strepavidin-like phosphatease conjugate, a chemiflurorensce and a chemiluminescent material. Preferably, but not limited thereto, Cy3 and Cy5 were used in the preferred embodiment of the present invention.

The kit may additionally include a reaction reagent, which is a buffer used for hybridization, reverse transcriptase for synthesizing cDNA from RNA, cNTPs and rNTP (premixed or separated feed), chemical inducer of fluorescent dyes It may be composed of a labeling reagent, such as a washing buffer, but is not limited thereto, and may include all reaction reagents required for hybridization of DNA microarray chips known to those skilled in the art.

In addition, the present invention provides a kit for confirming exposure to phenanthrene comprising a primer pair capable of amplifying the biomarker gene.

Primer of the kit for confirmation is preferably used two or more forward and reverse primer pairs selected from the group consisting of the sequence described in SEQ ID NO: 1 to 56, but is not limited thereto, and complementary to the biomarker gene It is possible to amplify a biomarker gene, and both forward and reverse primer pairs designed to be 100 to 300 bp may be used.

Hereinafter, the present invention will be described in detail by way of examples.

However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.

< Example  1> Cell Culture and Chemical Treatment

<1-1> Cell Culture

HepG2 cells (Korea Cell Line Bank), a human liver cancer cell line, were cultured using DMEM medium (Gibro-BRL, USA) to which 10% FBS was added until they grew from 100 dishes to 80%. The present inventors have selected phenanthrene, a substance having carcinogenicity, as one of the polycyclic aromatic hydrocarbons through existing studies and reports, and dissolved it in DMSO. Vehicle concentration was less than 0.1% in all experiments.

<1-2> MTT assay and chemical treatment

MTT experiments were performed using HepG2 cell lines by the method of Mossman et al . ( J. Immunol . Methods , 65, 55-63, 1983). Cells were treated with phenanthrene dissolved in DMSO in DMEM medium (Gibro-BRL, USA) with 4 × 10 ⁵ / well cell counts in 24-well plates and after 48 h MTT (3-4,5-dimethylthiazol-2,5- 5 mg / ml of diphenyltetra zolium bromide) was added to the tube and incubated at 37 ° C. for 3 hours. Thereafter, the medium was removed and the formed formazan crystal was dissolved in 500 µl of DMSO. Transfer to a 96-well plate was aliquoted and the OD value was measured at absorbance 540 nm.

As a result of examining the cytotoxicity of phenanthrene in the HepG2 cell line, the test substance was precipitated and the cytotoxicity was not detected at the concentration of 500 uM or more, so the highest concentration at which the test substance was not precipitated was determined (see FIG. 1). Microarray experiments were performed.

< Example  2> Microarray  Experiment

<2-1> Isolation of Target RNA and Fluorescent Labeling

After dispensing HepG2 cells in a 100 mm dish at a concentration of 6 x 10 ⁶ cells / ml, the concentration of phenanthrene determined in Example <1-2> was treated for 48 hours. Thereafter, the whole cells were separated from the treated cells using a trizol reagent (Invitrogen life technologies, USA) according to the manufacturer's method, and purified using the RNeasy mini kit (Qiagen, USA). Genomic DNA was removed using RNase-free DNase set (Qiagen, USA) during RNA purification. The amount of each total RNA sample was measured by spectrophotometer, the concentration was confirmed by Agilent 2100 Bioanalyzer (Agilent Technologies, USA) and agarose gel electrophoresis.

<2-2> Labeled cDNA Preparation

CDNA was prepared using the total RNA of the phenanthrene treatment group obtained in Example 2-1 for oligo microarray analysis. The total RNA obtained above was mixed with 30 μg of oligo (dT) primer and 2 μg (1 μg / μl), reacted at 65 for 10 minutes, and then annealed in ice. Reagents were mixed as shown in Table 1 for Reverse Transcript reaction of the annealed RNA.

Configuration Volume (μl) 5X first strand buffer 6 dNTPs 0.6 0.1 M DDT 3 SuperScript II enzyme 3 Cy-3 or Cy-5 dUTP 2

Total RNA isolated from control HepG2 cell line was labeled with Cy3-dUTP (green), and RNA isolated from phenanthrene-treated HepG2 cell line was labeled with Cy5-dUTP (red). At this time, the two samples were mixed and purified using a Microcon YM-30 column (Millipore, USA).

<2-3> hybridization reaction

Hybridization and washing procedures were carried out according to the instructions of Genochem Co., Ltd. Hybridization was performed in a 62 ° C. oven for 12 hours. 44 k Whole Human Genome Oligo Microarray (Agilent, USA) was used as the DNA microarray chip. After washing (washing in 2XSSC / 0.1% SDS for 2 minutes, washing in 1XSSC for 3 minutes and 0.2XSSC for 2 minutes), the slides were dried by centrifugation at 800 rpm for 3 minutes.

<2-4> Fluorescence Image Acquisition

Hybridization images on the slides were scanned with the Genepix 4000B (Axon Instruments, USA). Chips washed with unbound genes were obtained with a fluorescence image using a laser fluorescence scanner. In this case, the green fluorescence image in the control group, the red fluorescence image represents the activity level of the gene specifically expressed only in the experimental group, and the yellow fluorescence image is the complementary color of green and red, which means that there is no significant difference between the two groups. Scanned images were analyzed with GenePix 4.1 software (Axon Instruments, USA) to obtain gene expression rates. The marker gene for phenanthrene was selected from the data thus obtained (see FIG. 2).

As a result, 0.69% (302 out of 44,000 genes) of the 44,000 genes present on the oligo chip showed an increase in the expression of Cy5 / Cy3 by 2.0 times or more by phenanthrene. The reduced gene was found to be 0.55% (244 of 44,000 genes).

At this time, as a result of classifying genes overexpressed or underexpressed by phenanthrene by function more than two times, MAPKinase Signaling Pathway, MAPKKK cascade, apoptosis, and mitotic cell cycle Mitotic cell cycle, cell cycle, cell differentiation, cell motility, cytoskeleton, morphogenesis, response to DNA damage stimulus, chemistry Response to chemical stimulus, Response to external stimulus, Response to stress, Immune response, Metabolism of xenobiotics by cytochrome p450), alcohol metabolism, lipid metabolism, phosphate metabolism, DNA metabolism, metal binding or transport, etc. He was selected as a relevant gene (Table 2 and 3). The genes have not been reported to be associated with toxicity in human liver cancer cells when treated with phenanthrene used in the present invention.

Gene whose expression is increased by phenanthrene Registration Number Gene name Gene abbreviation Ratio of medians (a) MAPKKK cascade NM_004420 DUSP8 Dual specificity phosphatase 8 2.27022762 L11329 DUSP2 Dual specificity phosphatase 2 2.521509104 BC094766 PKN1 Protein kinase N1 2.611916464 AY247738 TRIB3 Tribbles homolog 3 (Drosophila) 3.427077604 AK129595 GADD45B Growth arrest and DNA-damage-inducible, beta 2.909002115 AB208849 SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.512464675 (b) apoptosis X02812 TGFB1 Transforming growth factor, beta 1 (Camurati-Engelmann disease) 2.554984038 NM_198951 TGM2 Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 2.425204553 NM_147780 CTSB Cathepsin b 6.761908242 NM_078467 CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1) 3.526032425 NM_033027 AXUD1 AXIN1 up-regulated 1 2.066280072 NM_032797 AMID Apoptosis-inducing factor (AIF) -like mitochondrion-associated inducer of death 2.95773602 NM_021960 MCL1 Myeloid cell leukemia sequence 1 (BCL2-related) 2.054026296 NM_016639 TNFRSF12A Tumor necrosis factor receptor superfamily, member 12A 3.746215932 NM_016222 DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.205477132 NM_013246 CLC Cardiotrophin-like cytokine factor 1 4.597526212 NM_004401 DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.190487127 NM_004281 BAG3 BCL2-associated athanogene 3 2.164884932 NM_003897 IER3 Immediate early response 3 4.950342184 NM_003806 HRK Harakiri, BCL2 interacting protein (contains only BH3 domain) 2.177796496 NM_003639 IKBKG Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.051623671 NM_003311 PHLDA2 Pleckstrin homology-like domain, family A, member 2 4.282799556 NM_002737 PRKCA Protein kinase C, alpha 2.012857122 NM_002648 PIM1 Pim-1 oncogene 3.737780419 NM_002507 NGFR Nerve growth factor receptor (TNFR superfamily, member 16) 2.482350728 NM_002305 LGALS1 Lectin, galactoside-binding, soluble, 1 (galectin 1) 4.245909804 NM_001013398 IGFBP3 Insulin-like growth factor binding protein 3 4.531730708 BX640923 MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) 2.164995807 BX537586 STK17A Serine / threonine kinase 17a (apoptosis-inducing) 2.409247881 BG284742 P8 P8 protein (candidate of metastasis 1) 3.948814552 BE903247 PDCD6IP Programmed cell death 6 interacting protein 2.353912724 BC027949 P2RX1 Purinergic receptor P2X, ligand-gated ion channel, 1 2.354820929 BC006365 PSEN2 Presenilin 2 (Alzheimer disease 4) 2.30373691 AY869712 PPP1R13L Protein phosphatase 1, regulatory (inhibitor) subunit 13 like 2.23804243 AY028896 CARD10 Caspase recruitment domain family, member 10 2.056288566 AK122614 PPARD Peroxisome proliferative activated receptor, delta 2.180466538 AK092872 ERCC2 Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) 2.015784385 AK092808 RRAGC Ras-related GTP binding C 2.200055389 AJ001898 GDNF Glial cell derived neurotrophic factor 2.266726651 AF220656 PHLDA1 Pleckstrin homology-like domain, family A, member 1 2.913029067 AF055634 UNC5C Unc-5 homolog C (C. elegans) 2.232102487 AB209485 VEGF Vascular endothelial growth factor 2.586729647 AB096256 UNC5B Unc-5 homolog B (C. elegans) 2.494712272 AB007960 SH3GLB1 SH3-domain GRB2-like endophilin B1 2.073859898 (c) Cell cycle X06374 PDGFA Platelet-derived growth factor alpha polypeptide 3.648449058 S62138 DDIT3 DNA-damage-inducible transcript 3 3.151372441 NM_078487 CDKN2B Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.446415961 NM_012127 CIZ1 CDKN1A interacting zinc finger protein 1 2.112779143 NM_005883 APC2 Adenomatosis polyposis coli 2 2.027554756 NM_004196 CDKL1 Cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.235676726 NM_003236 TGFA Transforming growth factor, alpha 2.454842022 NM_001261 CDK9 Cyclin-dependent kinase 9 (CDC2-related kinase) 2.274633293 NM_001007271 DUSP13 Dual specificity phosphatase 13 3.149559996 CR749511 PARC P53-associated parkin-like cytoplasmic protein 2.094870225 CR623038 ID2 Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.550297967 CR618371 EGFR Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 2.491051316 BF965144 IFITM1 Interferon induced transmembrane protein 1 (9-27) 2.543270189 AK127679 DUSP1 Dual specificity phosphatase 1 3.914538862 AK096276 CCND3 Cyclin D3 2.857742717 AB209586 MAPK13 Mitogen-activated protein kinase 13 2.905554851 AB209465 PCTK1 PCTAIRE protein kinase 1 2.42577099 (d) Cell differentiation Z19588 SKIL SKI-like 2.309598449 NM_020429 SMURF1 SMAD specific E3 ubiquitin protein ligase 1 2.372078449 NM_014767 SPOCK2 Sparc / osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.257035739 NM_005979 S100A13 S100 calcium binding protein A13 2.109950945 NM_005187 CBFA2T3 Core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.158635593 NM_004364 CEBPA CCAAT / enhancer binding protein (C / EBP), alpha 2.495910641 NM_001769 CD9 CD9 antigen (p24) 3.096954587 NM_001718 BMP6 Bone morphogenetic protein 6 4.249835457 NM_000641 IL11 Interleukin 11 8.141513685 BX647459 SERPINE2 Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 3.471136219 BQ066037 RPS19 Ribosomal protein S19 2.194009056 BE791300 EDF1 Endothelial differentiation-related factor 1 2.562607823 BC038504 SNF1LK SNF1-like kinase 2.228180629 AL832287 ZAP70 Zeta-chain (TCR) associated protein kinase 70kDa 2.254538098 AK125742 PCGF1 Polycomb group ring finger 1 2.062207211 AK124709 NDRG1 N-myc downstream regulated gene 1 2.757508129 AB011157 PTDSR Phosphatidylserine receptor 2.09664569 (e) Cell motility NM_013255 MKLN1 Muskelin 1, intracellular mediator containing kelch motifs 2.095388213 NM_006572 GNA13 Guanine nucleotide binding protein (G protein), alpha 13 2.586638776 NM_002211 ITGB1 Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 2.037108612 CR601067 PLAUR Plasminogen activator, urokinase receptor 2.622923731 BC050456 THBS4 Thrombospondin 4 4.173162214 AK027389 CXCL16 Chemokine (C-X-C motif) ligand 16 2.172103299 AJ132099 VNN1 Vanin 1 2.495809111 (f) Cytoskeleton XM_371354 FLJ10157 Hypothetical protein FLJ10157 3.585853829 XM_208313 TPM3 Similar to tropomyosin 4 2.031835381 XM_208270 ACR Acrosin-like protease 2.236260141 NM_203353 PDLIM7 PDZ and LIM domain 7 (enigma) 4.41339331 NM_201382 PLEC1 Plectin 1, intermediate filament binding protein 500kDa 2.281171511 NM_182961 SYNE1 Spectrin repeat containing, nuclear envelope 1 3.139279289 NM_181826 NF2 Neurofibromin 2 (bilateral acoustic neuroma) 2.07772497 NM_172069 PLEKHH2 Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 2.056655736 NM_022648 TNS Tensin 1 2.710366065 NM_017556 FBLP-1 Filamin binding LIM protein 1 6.033760457 NM_016081 KIAA0992 Palladin, cytoskeletal associated protein 2.883352333 NM_006617 NES Nestin 13.84724765 NM_006262 PRPH Peripherin 10.7669125 NM_005100 AKAP12 A kinase (PRKA) anchor protein (gravin) 12 4.230966504 NM_004368 CNN2 Calponin 2 2.419959379 NM_003388 CYLN2 Cytoplasmic linker 2 5.466743523 NM_003370 VASP Vasodilator-stimulated phosphoprotein 2.470396656 NM_003128 SPTBN1 Spectrin, beta, non-erythrocytic 1 3.389586475 NM_002705 PPL Periplakin 4.391168596 NM_002475 MLC1SA Myosin light chain 1 slow a 2.045728107 NM_002018 FLII Flightless I homolog (Drosophila) 2.923717161 NM_001465 FYB FYN binding protein (FYB-120 / 130) 2.243075989 NM_001069 TUBB2 Tubulin, beta 2A 2.078002541 CR625172 MGC8685 Tubulin, beta 2B 2.022491047 CR616919 KRT18 Keratin 18 2.254726412 CR606241 ACTG1 Actin, gamma 1 4.329668087 CB240572 MYH11 Myosin, heavy polypeptide 11, smooth muscle 2.226688186 BX648253 PTPN3 Protein tyrosine phosphatase, non-receptor type 3 2.228540111 BX648190 WDR1 WD repeat domain 1 3.15399225 BX641076 ACTN1 Actinin, alpha 1 2.072263838 BX537978 EPB41L1 Erythrocyte membrane protein band 4.1-like 1 2.347311112 BG121847 NUDC Nuclear distribution gene C homolog (A. nidulans) 2.810520113 BC068013 MYO1C Myosin IC 2.077468702 BC065499 MAST2 Microtubule associated serine / threonine kinase 2 2.684272001 BC051890 TUBG2 Tubulin, gamma 2 2.064679402 BC041874 MAP1LC3B Microtubule-associated protein 1 light chain 3 beta 2.030971208 BC012597 ACTA1 Actin, alpha 1, skeletal muscle 2.304539673 AY484427 KIF17 Kinesin family member 17 2.353016258 AK130546 STOML2 Stomatin (EPB72) -like 2 2.03643507 AK124711 CORO2B Coronin, actin binding protein, 2B 3.293861898 AK123974 MYL5 Myosin, light polypeptide 5, regulatory 2.023013016 AK092792 LOC389833 Similar to hypothetical protein MGC27019 2.389366922 AK026518 MYOHD1 Myosin head domain containing 1 2.059851337 AK024500 NICAL Microtubule associated monoxygenase, calponin and LIM domain containing 1 4.245993327 AF085886 FLJ46675 Ribosomal protein L29 pseudogene 2 2.603966059 AB209997 MYO9B Myosin IXB 2.009959651 (g) Morphogenesis Y12692 WNT11 Wingless-type MMTV integration site family, member 11 3.084421035 Y11307 CYR61 Cysteine-rich, angiogenic inducer, 61 3.733165979 X17033 ITGA2 Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.366215982 U41763 CLTCL1 Clathrin, heavy polypeptide-like 1 2.040973437 NM_153609 TMPRSS6 Transmembrane protease, serine 6 2.727002631 NM_031483 ITCH Itchy homolog E3 ubiquitin protein ligase (mouse) 2.476782073 NM_024342 GRLF1 Glucocorticoid receptor DNA binding factor 1 2.420894178 NM_017555 EGLN2 Egl nine homolog 2 (C. elegans) 2.239028595 NM_016569 TBX3 T-box 3 (ulnar mammary syndrome) 2.291924172 NM_004148 NINJ1 Ninjurin 1 3.079151972 NM_003377 VEGFB Vascular endothelial growth factor B 2.245728727 NM_001983 ERCC1 Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) 2.044162332 NM_001552 IGFBP4 Insulin-like growth factor binding protein 4 2.024402634 NM_001430 EPAS1 Endothelial PAS domain protein 1 4.033078615 NM_001300 KLF6 Kruppel-like factor 6 3.506436022 NM_001012661 SLC3A2 Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 4.490498433 NM_000596 IGFBP1 Insulin-like growth factor binding protein 1 2.537989362 NM_000474 TWIST1 Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) 2.868639316 BX649103 ChGn Chondroitin beta1,4 N-acetylgalactosaminyltransferase 2.71666046 BM913048 TIMP1 TIMP metallopeptidase inhibitor 1 12.6273547 BM904612 S100A6 S100 calcium binding protein A6 (calcyclin) 4.459584806 BM556279 EMP3 Epithelial membrane protein 3 2.776375864 BC015041 VAT1 Family with sequence similarity 82, member C 2.828306176 AY258066 OKL38 Pregnancy-induced growth inhibitor 2.006590778 AK126729 NDRG4 NDRG family member 4 2.992338668 AK090459 NFE2L1 Nuclear factor (erythroid-derived 2) -like 1 2.067852387 AK074163 ROBO4 Roundabout homolog 4, magic roundabout (Drosophila) 2.253993016 AK024680 FLJ21027 fis CDNA: FLJ21027 fis, clone CAE07110 3.277997184 AF176422 HEY1 Hairy / enhancer-of-split related with YRPW motif 1 6.385567161 AF003837 JAG1 Jagged 1 (Alagille syndrome) 3.357641161 AB209322 SEMA3B Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.514207227 AB011150 NRXN1 Neurexin 1 2.651119398 (h) Response to chemical stimulus NM_201589 MAFA V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 2.289466133 NM_052999 CKLFSF1 CKLF-like MARVEL transmembrane domain containing 1 2.154500421 NM_006644 HSPH1 Heat shock 105kDa / 110kDa protein 1 2.052814832 NM_005438 FOSL1 FOS-like antigen 1 4.369479447 NM_004996 ABCC1 ATP-binding cassette, sub-family C (CFTR / MRP), member 1 2.496546667 NM_002658 PLAU Plasminogen activator, urokinase 3.118938277 NM_001353 AKR1C1 Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha) -hydroxysteroid dehydrogenase) 4.189449913 H18681 C20orf139 Sulfiredoxin 1 homolog (S. cerevisiae) 3.459820496 DR004094 HAMP Hepcidin antimicrobial peptide 8.454862939 BC082272 KCNMB3 Potassium large conductance calcium-activated channel, subfamily M beta member 3 5.908505574 BC040494 DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.118589339 BC018064 ATF6 Activating transcription factor 6 2.200518512 BC006523 SGK2 Serum / glucocorticoid regulated kinase 2 2.324097135 AK090482 CXCL12 Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 2.095056818 AF219946 TULP4 Tubby like protein 4 2.152711359 AB209112 SLC2A8 Solute carrier family 2, (facilitated glucose transporter) member 8 2.096424216 (i) Response to external stimulus NM_005242 F2RL1 Coagulation factor II (thrombin) receptor-like 1 2.472382781 NM_001002029 C4A Complement component 4B, telomeric 2.443397995 NM_000539 RHO Rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant) 3.513455205 BX649164 PAI serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 12.37514297 BM918324 LY96 Lymphocyte antigen 96 2.167248213 AB209647 NCF2 Neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) 12.87547312 (j) Response to stress NM_152221 CSNK1E Casein kinase 1, epsilon 2.178753696 NM_017999 RNF31 Ring finger protein 31 2.570292632 NM_016819 OGG1 8-oxoguanine DNA glycosylase 2.533863905 NM_016816 OAS1 2 ', 5'-oligoadenylate synthetase 1, 40 / 46kDa 3.501233276 NM_012235 SCAP SREBP cleavage-activating protein 2.060092593 NM_006384 CIB1 Calcium and integrin binding 1 (calmyrin) 2.25718134 NM_001779 CD58 CD58 antigen, (lymphocyte function-associated antigen 3) 2.034681567 CB055213 ICOSLG Inducible T-cell co-stimulator ligand 2.619181365 BX641029 MASP1 Mannan-binding lectin serine peptidase 1 (C4 / C2 activating component of Ra-reactive factor) 2.025636667 BQ053419 BATF Basic leucine zipper transcription factor, ATF-like 2.554587227 BC039299 STIP1 Stress-induced-phosphoprotein 1 (Hsp70 / Hsp90-organizing protein) 2.76836206 AY055760 DAF Decay accelerating factor for complement (CD55, Cromer blood group system) 2.031359498 AK130188 FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 2.136850952 AK095326 MUS81 MUS81 endonuclease homolog (yeast) 2.238016633 (k) Immune response NM_017670 OTUB1 OTU domain, ubiquitin aldehyde binding 1 2.032834107 NM_003004 SECTM1 Secreted and transmembrane 1 2.491208324 NM_002309 LIF Hypothetical protein MGC20647 3.230632598 NM_001421 ELF4 E74-like factor 4 (ets domain transcription factor) 3.478175442 NM_000418 IL4R Interleukin 4 receptor 2.422846596 BI909222 FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.289239011 BF569086 NK4 Interleukin 32 3.196970924 BC014470 AZGP1 Alpha-2-glycoprotein 1, zinc 2.206481506 (l) Metabolism of xenobiotics by cytochrome p450 BC020744 AKR1C4 Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) 4.026497244 BQ939577 AKR1C3 Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 3.534961959 NM_000499 CYP1A1 Cytochrome P450, family 1, subfamily A, polypeptide 1 7.800377521 NM_030622 CYP2S1 Cytochrome P450, family 2, subfamily S, polypeptide 1 9.165266222 (m) Alcohol metabolism NM_184041 ALDOA Aldolase A, fructose-bisphosphate 2.484342488 NM_024307 MGC4171 Hypothetical protein LOC283901 2.180571996 NM_005336 HDLBP High density lipoprotein binding protein (vigilin) 2.05207069 NM_002627 PFKP Phosphofructokinase, platelet 2.236435695 BX648281 LDLR Low density lipoprotein receptor (familial hypercholesterolemia) 2.085256265 BC069201 FLJ22761 Hexokinase domain containing 1 4.73345014 BC030207 NR0B2 Nuclear receptor subfamily 0, group B, member 2 2.284100365 AL833069 KIAA1434 Hypothetical protein KIAA1434 4.079142767 AK124656 ENO2 Enolase 2 (gamma, neuronal) 2.112298881 AK094474 RHOC Ras homolog gene family, member C 3.594584812 AK093461 ISYNA1 Myo-inositol 1-phosphate synthase A1 2.735404779 AB053232 GAL3ST3 Galactose-3-O-sulfotransferase 3 2.093680717 AB045292 TMEM8 Transmembrane protein 8 (five membrane-spanning domains) 3.707677792 (n) Lipid metabolism NM_004753 DHRS3 Dehydrogenase / reductase (SDR family) member 3 3.595855915 NM_002900 RBP3 Retinol binding protein 3, interstitial 2.028996567 NM_001995 ACSL1 Acyl-CoA synthetase long-chain family member 1 2.361560571 NM_000018 ACADVL Acyl-Coenzyme A dehydrogenase, very long chain 2.211132906 BC094756 CRA Myotubularin related protein 11 6.444425873 BC050553 NTE Neuropathy target esterase 2.090667892 BC033110 HSD17B1 Hydroxysteroid (17-beta) dehydrogenase 1 2.073981426 AY268890 TPP1 Tripeptidyl peptidase I 2.014344437 AK172798 CPT1A Carnitine palmitoyltransferase 1A (liver) 2.657313685 AK096809 CYP4F8 Cytochrome P450, family 4, subfamily F, polypeptide 8 2.203372749 AK000600 SIAT7D ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) -N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 2.507339213 AB002454 CYP4F3 Cytochrome P450, family 4, subfamily F, polypeptide 3 2.080620209 (o) Phosphate metabolism Z29093 DDR1 Discoidin domain receptor family, member 1 2.462491605 Z25424 MKNK2 MAP kinase interacting serine / threonine kinase 2 3.947091085 XM_291277 DKFZp761P0423 Hypothetical protein DKFZp761P0423 2.109338154 XM_038150 MAST3 Microtubule associated serine / threonine kinase 3 2.304842007 U88357 ERBB3 V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 2.152283406 NM_025195 TRIB1 Tribbles homolog 1 (Drosophila) 2.315137327 NM_020639 RIPK4 Receptor-interacting serine-threonine kinase 4 2.672053723 NM_014172 PHPT1 Phosphohistidine phosphatase 1 2.642737979 NM_006254 PRKCD Protein kinase C, delta 2.014946828 NM_005415 SLC20A1 Solute carrier family 20 (phosphate transporter), member 1 3.900408718 NM_005026 PIK3CD Phosphoinositide-3-kinase, catalytic, delta polypeptide 2.165050096 NM_004431 EPHA2 EPH receptor A2 2.243829574 NM_004419 DUSP5 Dual specificity phosphatase 5 20.01504556 NM_004327 BCR Breakpoint cluster region 2.52856075 NM_004231 ATP6V1F ATPase, H + transporting, lysosomal 14kDa, V1 subunit F 2.2322534 NM_004090 DUSP3 Dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) 2.065252084 NM_002843 PTPRJ Protein tyrosine phosphatase, receptor type, J 3.168884768 NM_002496 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 2.199394599 NM_001001852 PIM3 Pim-3 oncogene 2.180634311 L76191 IRAK1 Interleukin-1 receptor-associated kinase 1 2.360632325 D15049 PTPRH Protein tyrosine phosphatase, receptor type, H 3.186653351 BC065207 ATP6V0D2 ATPase, H + transporting, lysosomal 38kDa, V0 subunit d isoform 2 5.710088632 BC035578 STK24 Serine / threonine kinase 24 (STE20 homolog, yeast) 2.566951703 BC028724 DUSP18 Dual specificity phosphatase 18 2.143797295 AL117482 ULK3 Unc-51-like kinase 3 (C. elegans) 2.125849273 AK126879 PCTK3 PCTAIRE protein kinase 3 2.761552709 AB209416 ILK Integrin-linked kinase-2 2.32916339 (p) metal-binding NM_000782 CYP24A1 Cytochrome P450, family 24, subfamily A, polypeptide 1 5.622641332 CR597101 ZFP36 Zinc finger protein 36, C3H type, homolog (mouse) 5.024789852 CR936799 FHL2 Four and a half LIM domains 2 4.675381268 M24898 NR1D1 Nuclear receptor subfamily 1, group D, member 1 4.136932409 AF132818 KLF5 Kruppel-like factor 5 (intestinal) 4.116680989 AK055337 ZNF213 Zinc finger protein 213 3.518376112 BC008834 PHF1 PHD finger protein 1 3.240448848 AK126918 GLIS2 GLIS family zinc finger 2 3.168801935 (q) Transport BC042692 CTL2 Solute carrier family 44, member 2 7.712276719 NM_002224 ITPR3 Inositol 1,4,5-triphosphate receptor, type 3 7.200316133 AK095363 AQP3 Aquaporin 3 7.089311726 NM_174953 ATP2A3 ATPase, Ca ++ transporting, ubiquitous 6.667638422 BC042390 VTI1B Vesicle transport through interaction with t-SNAREs homolog 1B (yeast) 5.395640679 NM_016113 TRPV2 Transient receptor potential cation channel, subfamily V, member 2 5.300948826 BM926478 RBP1 Retinol binding protein 1, cellular 4.257876297 NM_000069 CACNA1S Calcium channel, voltage-dependent, L type, alpha 1S subunit 3.933811596 AK002107 RAB3B RAB3B, member RAS oncogene family 3.719880481 NM_013321 SNX8 Sorting nexin 8 3.511433386 AK125026 SLC6A12 Solute carrier family 6 (neurotransmitter transporter, betaine / GABA), member 12 3.496824348 NM_005843 STAM2 Signal transducing adapter molecule (SH3 domain and ITAM motif) 2 3.317696437 AK092512 SLC16A5 Solute carrier family 16 (monocarboxylic acid transporters), member 5 3.29262947 U49248 ABCC2 ATP-binding cassette, sub-family C (CFTR / MRP), member 2 3.178849389 AK172792 SCNN1A Sodium channel, nonvoltage-gated 1 alpha 3.097482171 BC044656 CASC3 Cancer susceptibility candidate 3 3.092820884 (r) The others NM_203403 C9orf150 Chromosome 9 open reading frame 150 4.32887613 NM_080388 S100A16 S100 calcium binding protein A16 2.941590973 NM_031286 SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 3.942471639 NM_022153 PP2135 Chromosome 10 open reading frame 54 3.916865889 NM_004864 GDF15 Growth differentiation factor 15 8.033459664 NM_003330 TXNRD1 Thioredoxin reductase 1 2.016171386 NM_001013632 LOC343521 Similar to hypothetical protein 4833401D15 6.265797951 BX537968 LOC51149 Hypothetical LOC51149 6.382479399 BU945318 MT2A Hypothetical gene supported by X97260; BC070289 5.223401447 BQ683841 S100A11 S100 calcium binding protein A11 (calgizzarin) 6.425793559 BQ276852 TMSB10 Thymosin, beta 10 3.458398131 AK126182 KIAA1949 KIAA1949 4.256619831 AK124751 CAPN2 Calpain 2, (m / II) large subunit 3.00713376 AK095079 RGC32 Response gene to complement 32 2.452170107 AB075871 FLJ42654 Golgi transport 1 homolog A (S. cerevisiae) 2.344751749

Gene whose expression is reduced by phenanthrene Registration Number Gene name Gene abbreviation Ratio of medians (a) MAPKinase Signaling Pathway AK125150 MAPK8 Mitogen-activated protein kinase 8 0.37158159 NM_002758 MAP2K6 Mitogen-activated protein kinase kinase 6 0.273414428 NM_004612 TGFBR1 Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) 0.458974249 NM_145686 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 0.376276674 XM_042066 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 0.491648823 (b) MAPKKK cascade AB011123 TNIK TRAF2 and NCK interacting kinase 0.425973256 AB209031 C5 Complement component 5 0.372750614 NM_022740 HIPK2 Homeodomain interacting protein kinase 2 0.470548821 NM_148957 TNFRSF19 Tumor necrosis factor receptor superfamily, member 19 0.291773985 (c) Apoptosis AB208909 ITGB2 Integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) 0.282414049 AB209211 TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.359273874 AB209613 DNASE1L3 Deoxyribonuclease I-like 3 0.482302919 AK122825 HMGB1 High-mobility group box 1 0.405416859 AK127326 PHF17 PHD finger protein 17 0.448219525 AK223503 CASP1 Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.362727675 BC013326 GAS2 Growth arrest-specific 2 0.305181325 BC047698 IL7 Interleukin 7 0.391176777 D79987 ESPL1 Extra spindle poles like 1 (S. cerevisiae) 0.473063461 NM_000893 KNG1 Kininogen 1 0.315619852 NM_001012271 BIRC5 Effector cell peptidase receptor 1 0.347235792 NM_004938 DAPK1 Death-associated protein kinase 1 0.414470055 NM_005879 TRIP TRAF interacting protein 0.343197361 NM_014739 BCLAF1 BCL2-associated transcription factor 1 0.494434073 NM_018947 CYCS Cytochrome c, somatic 0.484434058 (d) Mitotic cell cycle AB033337 MPHOSPH1 M-phase phosphoprotein 1 0.350263811 AB209179 PLK1 Polo-like kinase 1 (Drosophila) 0.451487215 AB209337 CDC7 CDC7 cell division cycle 7 (S. cerevisiae) 0.490290043 AF053305 BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.226250944 AF053306 BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.287150649 AF345347 SPAG5 Sperm associated antigen 5 0.384598721 AK092638 CCNG2 Cyclin G2 0.369267319 AK222819 NUSAP1 Nucleolar and spindle associated protein 1 0.269711907 AL833191 SMC2L1 SMC2 structural maintenance of chromosomes 2-like 1 (yeast) 0.358469675 AY257469 CIT Citron (rho-interacting, serine / threonine kinase 21) 0.332700407 AY367065 ASPM Asp (abnormal spindle) -like, microcephaly associated (Drosophila) 0.190990469 BC011000 CDCA5 Cell division cycle associated 5 0.364789211 BC032677 UBE2C Ubiquitin-conjugating enzyme E2C 0.274784475 BC043502 NEK2 NIMA (never in mitosis gene a) -related kinase 2 0.358793697 BU675073 PTTG1 Pituitary tumor-transforming 1 0.384934848 BX647885 STMN1 Stathmin 1 / oncoprotein 18 0.438589617 CR592757 BRRN1 Barren homolog 1 (Drosophila) 0.44212003 CR597075 MAPRE2 Microtubule-associated protein, RP / EB family, member 2 0.401874825 CR604810 CCNA2 Cyclin A2 0.271797927 CR933728 CDC2 Cell division cycle 2, G1 to S and G2 to M 0.262198533 NM_000919 PAM Peptidylglycine alpha-amidating monooxygenase 0.395925124 NM_001790 CDC25C Cell division cycle 25C 0.286608881 NM_001798 CDK2 Cyclin-dependent kinase 2 0.483624317 NM_001813 CENPE Centromere protein E, 312kDa 0.197401094 NM_003318 TTK TTK protein kinase 0.216107553 NM_003981 PRC1 Protein regulator of cytokinesis 1 0.276570556 NM_004523 KIF11 Kinesin family member 11 0.324812081 NM_004701 CCNB2 Cyclin B2 0.265952387 NM_005983 SKP2 S-phase kinase-associated protein 2 (p45) 0.406254031 NM_006101 KNTC2 Kinetochore associated 2 0.156679448 NM_006845 KIF2C Kinesin family member 2C 0.427743351 NM_007375 TARDBP TAR DNA binding protein 0.465230823 NM_012112 TPX2 TPX2, microtubule-associated, homolog (Xenopus laevis) 0.437150291 NM_014750 DLG7 Discs, large homolog 7 (Drosophila) 0.241818618 NM_015097 CLASP2 Cytoplasmic linker associated protein 2 0.48734501 NM_016343 CENPF Centromere protein F, 350 / 400ka (mitosin) 0.245619925 NM_016426 GTSE1 G-2 and S-phase expressed 1 0.457747746 NM_018492 PBK PDZ binding kinase 0.250239701 NM_018685 ANLN Anillin, actin binding protein (scraps homolog, Drosophila) 0.293495946 NM_020242 KNSL7 Kinesin family member 15 0.308252464 NM_031966 CCNB1 Cyclin B1 0.349528487 NM_138555 KIF23 Kinesin family member 23 0.339120457 U65410 MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.287300335 (e) Cell cycle AB020656 CYLD Cylindromatosis (turban tumor syndrome) 0.499315321 AF033122 SESN1 Sestrin 1 0.479265095 AK074377 UHRF1 Chromosome 19 open reading frame 31 0.370230035 AK091170 CDKN2C Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.438659688 AK094323 NFYC Nuclear transcription factor Y, gamma 0.487100993 AY366508 LOH11CR2A Loss of heterozygosity, 11, chromosomal region 2, gene A 0.376070815 BC033086 TCF19 Transcription factor 19 (SC1) 0.419154236 BC040303 PTP4A1 Protein tyrosine phosphatase type IVA, member 1 0.290256096 BC040991 TFDP2 Transcription factor Dp-2 (E2F dimerization partner 2) 0.482076643 BC092412 SGOL2 Shugoshin-like 2 (S. pombe) 0.288603323 BQ278454 CKS1B CDC28 protein kinase regulatory subunit 1B 0.476447579 BX649128 SESN3 Sestrin 3 0.212281093 CD049340 AURKB Aurora kinase B 0.458421309 M89914 NF1 Neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) 0.448754702 NM_001005414 ZWINT ZW10 interactor antisense 0.305026839 NM_001008491 02-Sep Septin 2 0.433383282 NM_001274 CHEK1 CHK1 checkpoint homolog (S. pombe) 0.399470664 NM_002105 H2AFX H2A histone family, member X 0.462104547 NM_002388 MCM3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.493347362 NM_002417 MKI67 Antigen identified by monoclonal antibody Ki-67 0.211197951 NM_002875 RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.468496358 NM_003884 PCAF P300 / CBP-associated factor 0.347875633 NM_004526 MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) 0.451983867 NM_004847 AIF1 Allograft inflammatory factor 1 0.47451403 NM_005915 MCM6 MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) 0.492384723 NM_012090 MACF1 Microtubule-actin crosslinking factor 1 0.48194655 NM_012415 RAD54B RAD54 homolog B (S. cerevisiae) 0.416656782 NM_014264 PLK4 Polo-like kinase 4 (Drosophila) 0.305708065 NM_015714 G0S2 G0 / G1switch 2 0.212617258 NM_024680 FLJ23311 E2F transcription factor 8 0.383774423 XM_034274 MYBL1 V-myb myeloblastosis viral oncogene homolog (avian) -like 1 0.400969019 (f) Response to DNA damage stimulus AK001720 FLJ10858 Nei endonuclease VIII-like 3 (E. coli) 0.291006629 AY032677 POLQ Polymerase (DNA directed), theta 0.467324921 BC034480 BLM Bloom syndrome 0.451571042 BC073161 RAD51C RAD51 homolog C (S. cerevisiae) 0.450189769 CR600021 HMGB2 High-mobility group box 2 0.396981715 CR625391 RAD51AP1 RAD51 associated protein 1 0.284692163 CR936783 FLJ40869 Hypothetical protein LOC284952 0.35548351 DQ140356 KIAA1596 Fanconi anemia, complementation group M 0.41287346 NM_001067 TOP2A Topoisomerase (DNA) II alpha 170kDa 0.223422783 NM_001618 PARP1 Poly (ADP-ribose) polymerase family, member 1 0.41644492 NM_003362 UNG Uracil-DNA glycosylase 0.338199742 NM_006904 PRKDC Protein kinase, DNA-activated, catalytic polypeptide 0.484515215 NM_130398 EXO1 Exonuclease 1 0.466620279 (g) Response to stress AB020807 TLR6 Toll-like receptor 6 0.446477641 AB032980 DCDC2 Doublecortin domain containing 2 0.296124827 AB209866 TFPI Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.379601518 AK057015 HSPA4 Heat shock 70kDa protein 4 0.414580368 AK095515 IFIT1 Interferon-induced protein with tetratricopeptide repeats 1 0.227639802 AK122686 IF I factor (complement) 0.319972831 AK123010 RRM2 Ribonucleotide reductase M2 polypeptide 0.359436757 BC035582 TRIM22 Tripartite motif-containing 22 0.429859693 BX537894 LOC493869 Similar to RIKEN cDNA 2310016C16 0.430808753 M14338 PROS1 Protein S (alpha) 0.38758587 NM_000821 GGCX Gamma-glutamyl carboxylase 0.44786698 NM_000963 PTGS2 Prostaglandin-endoperoxide synthase 2 (prostaglandin G / H synthase and cyclooxygenase) 0.238558588 NM_001001547 CD36 CD36 antigen (collagen type I receptor, thrombospondin receptor) 0.427582662 NM_001512 GSTA4 Glutathione S-transferase A4 0.409696133 NM_001629 ALOX5AP Arachidonate 5-lipoxygenase-activating protein 0.370258001 NM_001752 CAT Catalase 0.48229097 NM_001837 CCR3 Chemokine (C-C motif) receptor 3 0.392999815 NM_001979 EPHX2 Epoxide hydrolase 2, cytoplasmic 0.409748537 NM_001994 F13B Coagulation factor XIII, B polypeptide 0.417103615 NM_002182 IL1RAP Interleukin 1 receptor accessory protein 0.470544224 NM_006120 HLA-DMA Major histocompatibility complex, class II, DM alpha 0.409381691 NM_173216 SIAT1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.395048885 NM_202002 FOXM1 Forkhead box M1 0.343164799 (h) Immune response AB163917 LRAP Leukocyte-derived arginine aminopeptidase 0.389545152 BC027881 AFP Alpha-fetoprotein 0.482598986 NM_015915 SPG3A Spastic paraplegia 3A (autosomal dominant) 0.320598706 (i) Metabolism of xenobiotics by cytochrome p450 NM_000671 ADH5 Alcohol dehydrogenase 5 (class III), chi polypeptide 0.415769885 J05428 UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.355949899 NM_000672 ADH6 Alcohol dehydrogenase 6 (class V) 0.240017477 M15943 ADH4 Alcohol dehydrogenase 4 (class II), pi polypeptide 0.369002372 (j) Alcohol metabolism AK223395 FBP1 Fructose-1,6-bisphosphatase 1 0.345975924 NM_000151 G6PC Glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease) 0.483865486 XM_113962 KIAA0650 Structural maintenance of chromosomes flexible hinge domain containing 1 0.481113604 (k) Lipid metabolism AB020644 ACSL6 Acyl-CoA synthetase long-chain family member 6 0.366796579 AB209907 PLD1 Phospholipase D1, phophatidylcholine-specific 0.49794399 AF285167 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.400576212 AF297872 TRERF1 Transcriptional regulating factor 1 0.424424442 AF303134 ALDH8A1 Aldehyde dehydrogenase 8 family, member A1 0.327216749 AF339053 PLA2G12B Phospholipase A2, group XIIB 0.403910882 AK096018 HADHSC L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain 0.477072516 AK124635 PCSK9 Proprotein convertase subtilisin / kexin type 9 0.354529299 AK127346 SIAT9 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.499800758 AL359559 AGPS Alkylglycerone phosphate synthase 0.466443577 AY691170 PLCL3 Phospholipase C-like 3 0.450889711 BG567934 APOM Apolipoprotein M 0.427865838 BX538214 C6orf167 Chromosome 6 open reading frame 167 0.361451579 BX640945 FADS2 Fatty acid desaturase 2 0.336986957 BX648473 PIGK Phosphatidylinositol glycan, class K 0.447642673 BX648557 HSD17B2 Hydroxysteroid (17-beta) dehydrogenase 2 0.423413453 CR749601 ETNK1 Death-associated protein kinase 3 0.342843288 NM_000859 HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.433628828 NM_001443 FABP1 Fatty acid binding protein 1, liver 0.462365086 NM_002130 HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0.425602232 NM_003725 RODH Hydroxysteroid (17-beta) dehydrogenase 6 0.369285922 NM_004845 PCYT1B Phosphate cytidylyltransferase 1, choline, beta 0.325080042 NM_014762 DHCR24 24-dehydrocholesterol reductase 0.482309072 NM_020139 DHRS6 Dehydrogenase / reductase (SDR family) member 6 0.485337426 NM_020918 GPAM Glycerol-3-phosphate acyltransferase, mitochondrial 0.487746412 NM_032523 OSBPL6 Oxysterol binding protein-like 6 0.450067001 NM_033505 SELI Selenoprotein I 0.451056253 Z28339 AKR1D1 Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) 0.452191754 (l) Phosphate metabolism AK024899 ENPP3 Ectonucleotide pyrophosphatase / phosphodiesterase 3 0.427540305 AK025546 PTPN4 Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.472674412 AK124910 ENPP2 Ectonucleotide pyrophosphatase / phosphodiesterase 2 (autotaxin) 0.360666366 BC035116 FLJ35059 fis CDNA FLJ30761 fis, clone FEBRA2000538 0.404383659 BC050565 PASK PAS domain containing serine / threonine kinase 0.448921606 L13436 NPR2 Natriuretic peptide receptor B / guanylate cyclase B (atrionatriuretic peptide receptor B) 0.354388276 NM_001005862 ERBB2 V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro / glioblastoma derived oncogene homolog (avian) 0.474857704 NM_005012 ROR1 Receptor tyrosine kinase-like orphan receptor 1 0.397847795 NM_006035 CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.474850606 NM_014791 MELK Maternal embryonic leucine zipper kinase 0.300625391 NM_023028 FGFR2 Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) 0.242322161 NM_080836 STK35 Serine / threonine kinase 35 0.424967125 (m) RNA metabolism AF419331 FUSIP1 FUS interacting protein (serine / arginine-rich) 1 0.412759748 AK091927 SFRS3 Splicing factor, arginine / serine-rich 3 0.420449485 BC010266 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1 0.462311144 BC012360 CTAGE5 CTAGE family, member 5 0.431418692 BC036046 PLRG1 Pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) 0.33089654 BC065384 PCF11 PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae) 0.39661398 BX537360 CPSF5 Nudix (nucleoside diphosphate linked moiety X) -type motif 21 0.474903583 BX537494 HNRPA2B1 Heterogeneous nuclear ribonucleoprotein A2 / B1 0.483235958 BX647784 HNRPR Heterogeneous nuclear ribonucleoprotein R 0.493832914 CA455267 PPIH Peptidyl prolyl isomerase H (cyclophilin H) 0.452735692 CR596214 HNRPA0 Heterogeneous nuclear ribonucleoprotein A0 0.492830856 NM_001326 CSTF3 Hypothetical protein LOC283267 0.488369566 NM_004640 BAT1 HLA-B associated transcript 1 0.464678802 NM_005463 HNRPDL Heterogeneous nuclear ribonucleoprotein D-like 0.44943189 NM_006924 SFRS1 Splicing factor, arginine / serine-rich 1 (splicing factor 2, alternate splicing factor) 0.409985251 NM_012426 SF3B3 Splicing factor 3b, subunit 3, 130 kDa 0.409610607 NM_018048 FLJ10292 Mago-nashi homolog 0.476610453 NM_030919 C20orf129 Chromosome 20 open reading frame 129 0.332805196 NM_031370 HNRPD Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.425073079 NM_138933 ACF Apobec-1 complementation factor 0.49507629 (n) metal-binding AB193259 ACE2 Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 0.239856518 BX648769 EWSR1 Ewing sarcoma breakpoint region 1 0.257110535 AB023154 DTX4 Deltex 4 homolog (Drosophila) 0.267621475 AL543755 VAV3 Vav 3 oncogene 0.299264024 M75106 CPB2 Carboxypeptidase B2 (plasma, carboxypeptidase U) 0.313049686 NM_021045 ZNF248 Zinc finger protein 248 0.320140997 AB209194 B4GALT6 UDP-Gal: betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 0.320685631 AF279145 ANTXR1 Anthrax toxin receptor 1 0.39857674 NM_025074 FRAS1 Fraser syndrome 1 0.481764106 (o) Transport AK025790 KIF20A Kinesin family member 20A 0.14986715 NM_006152 LRMP Lymphoid-restricted membrane protein 0.156975893 NM_000340 SLC2A2 Solute carrier family 2 (facilitated glucose transporter), member 2 0.199699724 AF071592 KIF4A Kinesin family member 4A 0.212426381 NM_013277 RACGAP1 Rac GTPase activating protein 1 0.219596171 AY043484 SCN1A Sodium channel, voltage-gated, type I, alpha 0.22219969 AY791349 KIF18A Kinesin family member 18A 0.225454794 NM_018018 SLC38A4 Solute carrier family 38, member 4 0.236711775 AK094603 FLJ37284 fis unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. 0.280097743 NM_021069 ARGBP2 Sorbin and SH3 domain containing 2 0.288175356 NM_001005747 CACNB4 Calcium channel, voltage-dependent, beta 4 subunit 0.306040228 AJ496568 SLC25A12 Solute carrier family 25 (mitochondrial carrier, Aralar), member 12 0.310081864 NM_030641 APOL6 Apolipoprotein L, 6 0.320365934 NM_173512 FLJ39822 Hypothetical protein FLJ39822 0.32237774 NM_000037 ANK1 Ankyrin 1, erythrocytic 0.329795837 NM_001011554 SLC13A3 Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.435944386 (p) The others AB091343 C10orf3 Centrosomal protein 55kDa 0.428171982 AK000643 ASB9 Ankyrin repeat and SOCS box-containing 9 0.260478398 AK055221 FBXO5 F-box protein 5 0.433580607 AK075271 SPTLC2L Serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2) 0.321365941 AK122685 GLUD1 Glutamate dehydrogenase 1 0.413665212 AK127098 FLJ10706 Chromosome 1 open reading frame 112 0.394085877 AL133031 MLR1 Transcription factor MLR1 0.323710764 AY007723 MAL2 Mal, T-cell differentiation protein 2 0.447551782 BC022255 Spc25 Spindle pole body component 25 homolog (S. cerevisiae) 0.399364168 BC041882 ATF7IP2 Activating transcription factor 7 interacting protein 2 0.398757895 BC052951 LMNB1 Lamin b1 0.286010243 BC098313 FLJ20641 Hypothetical protein FLJ20641 0.352377485 NM_001809 CENPA Centromere protein A, 17kDa 0.316448038 NM_145061 C13orf3 Chromosome 13 open reading frame 3 0.282096453 XM_372695 LOC390859 PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859), mRNA 0.461216656

< Example  3> Real time RT -PCR ( Real - time reverse transcriptase polymerase  chainreaction)

Of the genes overexpressed and underexpressed more than twice as in Example 2 induced by phenanthrene, 19 genes overexpressed by phenanthrene and 9 genes underexpressed were selected. These genes include the GeneBank accession No. BM913048 (TIMP metallopeptidase inhibitor 1), the GeneBank accession No. BX649164 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1) , GeneBank accession No. NM_004864 (Growth differentiation factor 15), GeneBank accession No. NM_000499 (Cytochrome P450, family 1, subfamily A, polypeptide 1), GeneBank accession No. ) AK095363 (Aquaporin 3), GeneBank accession No. NM_001013632 (Similar to hypothetical protein 4833401D15), GeneBank accession No. BC042390 (Vesicle transport through interaction with t-SNAREs homolog 1B (yeast)) , GeneBank accession No. BQ683841 (S100 calcium binding protein A11 (calgizzarin)), GeneBank accession No. NM_003897 (Immediate early response 3), GeneBank acce ssion No.) BM926478 (Retinol binding protein 1, cellular), GeneBank accession No. BU945318 (metallothionein 2A), GeneBank accession No. AK094474 (Ras homolog gene family, member C), gene GeneBank accession No. Y11307 (Cysteine-rich, angiogenic inducer, 61), GeneBank accession No. AY247738 (Tribbles homolog 3 (Drosophila)), GeneBank accession No. Z25424 (GeneBank accession No.) MAP kinase interacting serine / threonine kinase 2), GeneBank accession No. NM_001769 (CD9 antigen (p24)), GeneBank accession No. Y12692 (Wingless-type MMTV integration site family, member 11) , GeneBank accession No. X02812 (Transforming growth factor, beta 1 (Camurati-Engelmann disease)), GeneBank accession No. NM_000596 (Insulin-like growth factor binding protein 1), Gene accession number (GeneBank accession No.) NM_006101 (Kinetochore associa ted 2), GeneBank accession No. NM_003318 (TTK protein kinase), GeneBank accession No. NM_001067 (Topoisomerase (DNA) II alpha 170kDa), GeneBank accession No. NM_018492 (PDZ binding kinase), GeneBank accession No. U65410 (MAD2 mitotic arrest deficient-like 1 (yeast)), GeneBank accession No. AK074377 (Chromosome 19 open reading frame 31), Gene registration Number (GeneBank accession No.) CR600021 (High-mobility group box 2), Gene accession number (GeneBank accession No.) BC022255 (Spindle pole body component 25 homolog (S. cerevisiae)), GeneBank accession No. AB091343 (Centrosomal protein 55 kDa).

Quantitative real-time RT-PCR was performed using My IQ Real-time PCR (Bio-rad, USA) to investigate and quantify the expression changes of the genes.

Specifically, cDNA was synthesized by performing reverse transcription using an oligo dT primer and a Superscript kit (Omniscipt ^™ kit, Qiagen, Co., USA). To quantify the PCR products were stained with SYBR Green I stain (Bio-rad, USA). Cyberrin I staining is a staining method that binds to double-stranded DNA. As the double-stranded DNA is generated during PCR, the fluorescence intensity increases. First, primers for the target gene and endogenous control (GAPDH) used for PCR were added to the Cyberrin master mix, followed by PCR, followed by a primer optimization process to select an appropriate concentration. Was performed. Synthesized cDNA samples and each primer (Table 4) were mixed, PCR was performed after the addition of the Cyberrin master mix and analyzed using quantification software (see Table 5).

primer  order Registration Number Gene name PCR primer sequence BM913048 TIMPmetallopeptidaseinhibitor1 Sense (SEQ ID NO: 1) GATACTTCCACAGGTCCCACAAC Antisense (SEQ ID NO: 2) GCAAGAGTCCATCCTGCAGTT BX649164 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Sense (SEQ ID NO: 3) CAGACCAAGAGCCTCTCCAC Antisense (SEQ ID NO: 4) ATCACTTGGCCCATGAAAAG NM_004864 Growth differentiation factor 15 Sense (SEQ ID NO: 5) CCTGAGACACCCGATTCCT Antisense (SEQ ID NO: 6) ACAGTTCCATCAGACCAGCC NM_000499 Cytochrome P450, family 1, subfamily A, polypeptide 1 Sense (SEQ ID NO: 7) CACCATCCCCCACAGCAC Antisense (SEQ ID NO: 8) ACAAAGACACAACGCCCCTT AK095363 Aquaporin 3 Sense (SEQ ID NO: 9) TTCACGATCCACCCTTTCAGGCTA Antisense (SEQ ID NO: 10) ACACATACCTGCTGCCCATTCTCT NM_001013632 polo-like kinase 3 (Drosophila) Sense (SEQ ID NO: 11) GACTACTCCAATAAGTTCGGCTTTG Antisense (SEQ ID NO: 12) CATATGTGTGCCATCGTTGAAGA BC042390 Vesicle transport through interaction with t-SNAREs homolog 1B (yeast) Sense (SEQ ID NO: 13) GGGGGACTAACCTATCGAGAA Antisense (SEQ ID NO: 14) GATCCAGTGCTGATAGCAACC BQ683841 S100 calcium binding protein A11 (calgizzarin) Sense (SEQ ID NO: 15) AGTCCCTGATTGCTGTCTTCCAGA Antisense (SEQ ID NO: 16) ACCAGGGTCCTTCTGGTTCTTTGT NM_003897 Immediate early response 3 Sense (SEQ ID NO: 17) AGCCCTTTAATCTGACTTCGGAGC Antisense (SEQ ID NO: 18) CAGGTACGCCTGGTGTTTCTTTGT BM926478 Retinol binding protein 1, cellular Sense (SEQ ID NO: 19) AGGCATAGATGACCGCAAGT Antisense (SEQ ID NO: 20) ACCCTTCTGCACACACTGG BU945318 metallothionein 2A Sense (SEQ ID NO: 21) CTCTAGCCGCCTCTTCAGC Antisense (SEQ ID NO: 22) ACTCTTTGCATTTGCAGGAAC AK094474 Ras homolog gene family, member C Sense (SEQ ID NO: 23) ACCTGCCTCCTCATCGTCTTC Antisense (SEQ ID NO: 24) CACCTGCTTGCCGTCCAC Y11307 Cysteine-rich, angiogenic inducer, 61 Sense (SEQ ID NO: 25) ATTGTAGAAAGGAAGCCTTGCTCAT Antisense (SEQ ID NO: 26) TCCAATCGTGGCTGCATTAG AY247738 Tribbles homolog 3 (Drosophila) Sense (SEQ ID NO: 27) GTCTTCGCTGACCGTGAGA Antisense (SEQ ID NO: 28) CAGTCAGCACGCAGGAGTC NM_017572 MAP kinase interacting serine / threonine kinase 2 Sense (SEQ ID NO: 29)  CCATGGTCCTGCAGAGGT Antisense (SEQ ID NO: 30) TTCTGACCAGTCCTCCAGGT NM_001769 CD9 antigen (p24) Sense (SEQ ID NO: 31) GCACCAAGTGCATCAAATACCTGC Antisense (SEQ ID NO: 32) AGCCATAGTCCAATGGCAAGGACA Y12692 Wingless-type MMTV integration site family, member 11 Sense (SEQ ID NO: 33) TTCACTTGGAAGCCACCAGGAACA Antisense (SEQ ID NO: 34) TGGCCCTGAAAGGTCAAGTCTGTA X02812 Transforming growth factor, beta 1 (Camurati-Engelmann disease) Sense (SEQ ID NO: 35) GCAGCACGTGGAGCTGTA Antisense (SEQ ID NO: 36) CAGCCGGTTGCTGAGGTA NM_000596 Insulin-like growth factor binding protein 1 Sense (SEQ ID NO: 37) ATCATTCCATCCTTTGGGACGCCA Antisense (SEQ ID NO: 38) TGTCTCCTGTGCCTTGGCTAAACT NM_006101 Kinetochore associated 2 Sense (SEQ ID NO: 39) TGCTACACATGTTGGGTCTGTA Antisense (SEQ ID NO: 40) CCGAGAGATCTTCTGACATGC NM_003318 TTK protein kinase Sense (SEQ ID NO: 41) TCATGCCCATTTGGAAGAGTCCCA Antisense (SEQ ID NO: 42) AGGCACAACCAAATCTCGGCATTC NM_001067 Topoisomerase (DNA) II alpha 170kDa Sense (SEQ ID NO: 43) CTAGTTAATGCTGCGGACAACA Antisense (SEQ ID NO: 44) CATTTCGACCACCTGTCACTT NM_018492 PDZ binding kinase Sense (SEQ ID NO: 45) TCTGGACTGAGAGTGGCTTTCACA Antisense (SEQ ID NO: 46) AGCCAAGCTTCTGCATAAACGGAG U65410 MAD2 mitotic arrest deficient-like 1 (yeast) Sense (SEQ ID NO: 47) ACTTAAATATCTCCCTACCTATACTGAGTCAA Antisense (SEQ ID NO: 48) TAGTAACTGTAGATGGAAAAACTTGTGCTA AK074377 Chromosome 19 open reading frame 31 Sense (SEQ ID NO: 49) CTGGTACGACGCGGAGAT Antisense (SEQ ID NO: 50) CGACAGTCGTTCAGAGAATCA CR600021 High-mobility group box 2 Sense (SEQ ID NO: 51) CTTGGCACGATATGCAGCAA Antisense (SEQ ID NO: 52) CAGCCAAAGATAAACAACCATATGA BC022255 Spindle pole body component 25 homolog (S. cerevisiae) Sense (SEQ ID NO: 53) GAATGGTTGAGATGTTTCTGGA Antisense (SEQ ID NO: 54) GCAATCAATTTTAACAAGTTATCCTTT AB091343 Centrosomal protein 55kDa Sense (SEQ ID NO: 55) GCTGTGCATTTCTCTTGGCAGTGA Antisense (SEQ ID NO: 56) TAGACGCTGCTCACCACATTCTGT

Real time quantification PCR  result Registration Number Gene name Abbreviation Microarray   (Cy3 / Cy5 ratio) real time PCR  (Relative magnification) Overexpression genes BM913048 TIMP metallopeptidase inhibitor 1 TIMP1 12.63 12.67 BX649164 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 PAI 12.38 15.17 NM_004864 Growth differentiation factor 15 GDF15 8.03 52.89 NM_000499 Cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A1 7.80 12.67 AK095363 Aquaporin 3 AQP3 7.09 9.06 NM_001013632 Similar to hypothetical protein 4833401D15 LOC343521 6.27 6.68 BC042390 Vesicle transport through interaction with t-SNAREs homolog 1B (yeast) VTI1B 5.40 8.06 BQ683841 S100 calcium binding protein A11 (calgizzarin) S100A11 5.14 8.53 NM_003897 Immediate early response 3 IER3 4.95 4.71 BM926478 Retinol binding protein 1, cellular RBP1 4.26 5.24 BU945318 metallothionein 2A MT2A 4.12 4.28 AK094474 Ras homolog gene family, member C RHOC 3.59 1.53 Y11307 Cysteine-rich, angiogenic inducer, 61 CYR61 3.51 5.23 AY247738 Tribbles homolog 3 (Drosophila) TRIB3 3.43 1.85 Z25424 MAP kinase interacting serine / threonine kinase 2 MKNK2 3.41 4.66 NM_001769 CD9 antigen (p24) CD9 3.10 4.52 Y12692 Wingless-type MMTV integration site family, member 11 WNT11 3.08 4.00 X02812 Transforming growth factor, beta 1 (Camurati-Engelmann disease) TGFB1 2.55 4.46 NM_000596 Insulin-like growth factor binding protein 1 IGFBP1 2.54 2.56 Low expression genes NM_006101 Kinetochore associated 2 KNTC2 0.18 0.17 NM_003318 TTK protein kinase TTK 0.22 0.27 NM_001067 Topoisomerase (DNA) II alpha 170kDa TOP2A 0.22 0.29 NM_018492 PDZ binding kinase PBK 0.25 0.23 U65410 MAD2 mitotic arrest deficient-like 1 (yeast) MAD2L1 0.29 0.29 AK074377 Chromosome 19 open reading frame 31 UHRF1 0.37 0.57 CR600021 High-mobility group box 2 HMGB2 0.40 0.35 BC022255 Spindle pole body component 25 homolog (S. cerevisiae) Spc25 0.40 0.27 AB091343 Centrosomal protein 55kDa C10orf3 0.43 0.52

As a result, it was confirmed that the gene expression patterns of 19 overexpression genes and 9 low expression genes were very similar to oligo microarray results of gene expression by phenanthrene.

1 is a graph illustrating the cytotoxicity of phenanthrene in human liver cancer cell lines.

Figure 2 is a diagram showing the results of analyzing the gene expression pattern of human liver cancer cell line treated with phenanthrene using a microarray chip.

<110> Korea Institute of Science and Technology <120> Biomarkers for identification of exposure to phenanthrene and the          method of identification using the same <130> 8p-07-49 <160> 56 <170> KopatentIn 1.71 <210> 1 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> sense primer of TIMPmetallopeptidasein hibitor1 <400> 1 gatacttcca caggtcccac aac 23 <210> 2 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of TIMPmetallopeptidasein hibitor1 <400> 2 gcaagagtcc atcctgcagt t 21 <210> 3 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> sense primer of serpin peptidase inhibitor, clade E (nexin,          plasminogen activator inhibitor type 1), member 1 <400> 3 cagaccaaga gcctctccac 20 <210> 4 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of serpin peptidase inhibitor, clade E (nexin,          plasminogen activator inhibitor type 1), member 1 <400> 4 atcacttggc ccatgaaaag 20 <210> 5 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Growth differentiation factor 15 <400> 5 cctgagacac ccgattcct 19 <210> 6 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Growth differentiation factor 15 <400> 6 acagttccat cagaccagcc 20 <210> 7 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Cytochrome P450, family 1, subfamily A,          polypeptide 1 <400> 7 caccatcccc cacagcac 18 <210> 8 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Cytochrome P450, family 1, subfamily A,          polypeptide 1 <400> 8 acaaagacac aacgcccctt 20 <210> 9 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Aquaporin 3 <400> 9 ttcacgatcc accctttcag gcta 24 <210> 10 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Aquaporin 3 <400> 10 acacatacct gctgcccatt ctct 24 <210> 11 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> sense primer of polo-like kinase 3 (Drosophila) <400> 11 gactactcca ataagttcgg ctttg 25 <210> 12 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of polo-like kinase 3 (Drosophila) <400> 12 catatgtgtg ccatcgttga aga 23 <210> 13 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Vesicle transport through interaction with          t-SNAREs homolog 1B (yeast) <400> 13 gggggactaa cctatcgaga a 21 <210> 14 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Vesicle transport through interaction with          t-SNAREs homolog 1B (yeast) <400> 14 gatccagtgc tgatagcaac c 21 <210> 15 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> sense primer of S100 calcium binding protein A11 (calgizzarin) <400> 15 agtccctgat tgctgtcttc caga 24 <210> 16 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of S100 calcium binding protein A11 (calgizzarin) <400> 16 accagggtcc ttctggttct ttgt 24 <210> 17 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Immediate early response 3 <400> 17 agccctttaa tctgacttcg gagc 24 <210> 18 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Immediate early response 3 <400> 18 caggtacgcc tggtgtttct ttgt 24 <210> 19 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Retinol binding protein 1, cellular <400> 19 aggcatagat gaccgcaagt 20 <210> 20 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Retinol binding protein 1, cellular <400> 20 acccttctgc acacactgg 19 <210> 21 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> sense primer of metallothionein 2A <400> 21 ctctagccgc ctcttcagc 19 <210> 22 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of metallothionein 2A <400> 22 actctttgca tttgcaggaa c 21 <210> 23 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Ras homolog gene family, member C <400> 23 acctgcctcc tcatcgtctt c 21 <210> 24 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Ras homolog gene family, member C <400> 24 cacctgcttg ccgtccac 18 <210> 25 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Cysteine-rich, angiogenic inducer, 61 <400> 25 attgtagaaa ggaagccttg ctcat 25 <210> 26 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Cysteine-rich, angiogenic inducer, 61 <400> 26 tccaatcgtg gctgcattag 20 <210> 27 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Tribbles homolog 3 (Drosophila) <400> 27 gtcttcgctg accgtgaga 19 <210> 28 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Tribbles homolog 3 (Drosophila) <400> 28 cagtcagcac gcaggagtc 19 <210> 29 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> sense primer of MAP kinase interacting serine / threonine kinase 2 <400> 29 ccatggtcct gcagaggt 18 <210> 30 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of MAP kinase interacting serine / threonine          kinase 2 <400> 30 ttctgaccag tcctccaggt 20 <210> 31 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> sense primer of CD9 antigen (p24) <400> 31 gcaccaagtg catcaaatac ctgc 24 <210> 32 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of CD9 antigen (p24) <400> 32 agccatagtc caatggcaag gaca 24 <210> 33 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Wingless-type MMTV integration site family,          member 11 <400> 33 ttcacttgga agccaccagg aaca 24 <210> 34 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Wingless-type MMTV integration site family,          member 11 <400> 34 tggccctgaa aggtcaagtc tgta 24 <210> 35 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Transforming growth factor, beta          1 (Camurati-Engelmann disease) <400> 35 gcagcacgtg gagctgta 18 <210> 36 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Transforming growth factor, beta          1 (Camurati-Engelmann disease) <400> 36 cagccggttg ctgaggta 18 <210> 37 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Insulin-like growth factor binding protein 1 <400> 37 atcattccat cctttgggac gcca 24 <210> 38 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Insulin-like growth factor binding protein 1 <400> 38 tgtctcctgt gccttggcta aact 24 <210> 39 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Kinetochore associated 2 <400> 39 tgctacacat gttgggtctg ta 22 <210> 40 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Kinetochore associated 2 <400> 40 ccgagagatc ttctgacatg c 21 <210> 41 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> sense primer of TTK protein kinase <400> 41 tcatgcccat ttggaagagt ccca 24 <210> 42 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of TTK protein kinase <400> 42 aggcacaacc aaatctcggc attc 24 <210> 43 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Topoisomerase (DNA) II alpha 170kDa <400> 43 ctagttaatg ctgcggacaa ca 22 <210> 44 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Topoisomerase (DNA) II alpha 170kDa <400> 44 catttcgacc acctgtcact t 21 <210> 45 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> sense primer of PDZ binding kinase <400> 45 tctggactga gagtggcttt caca 24 <210> 46 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of PDZ binding kinase <400> 46 agccaagctt ctgcataaac ggag 24 <210> 47 <211> 32 <212> DNA <213> Artificial Sequence <220> <223> sense primer of MAD2 mitotic arrest deficient-like 1 (yeast) <400> 47 acttaaatat ctccctacct atactgagtc aa 32 <210> 48 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of MAD2 mitotic arrest deficient-like 1 (yeast) <400> 48 tagtaactgt agatggaaaa acttgtgcta 30 <210> 49 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Chromosome 19 open reading frame 31 <400> 49 ctggtacgac gcggagat 18 <210> 50 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Chromosome 19 open reading frame 31 <400> 50 cgacagtcgt tcagagaatc a 21 <210> 51 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> sense primer of High-mobility group box 2 <400> 51 cttggcacga tatgcagcaa 20 <210> 52 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of High-mobility group box 2 <400> 52 cagccaaaga taaacaacca tatga 25 <210> 53 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Spindle pole body component 25 homolog (S.          cerevisiae) <400> 53 gaatggttga gatgtttctg ga 22 <210> 54 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Spindle pole body component 25 homolog (S.          cerevisiae) <400> 54 gcaatcaatt ttaacaagtt atccttt 27 <210> 55 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> sense primer of Centrosomal protein 55kDa <400> 55 gctgtgcatt tctcttggca gtga 24 <210> 56 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> antisense primer of Centrosomal protein 55 kDa <400> 56 tagacgctgc tcaccacatt ctgt 24  

Claims (15)

Biomarker for confirming the exposure to phenanthrene comprising a gene selected from the following groups: Gene accession number (GeneBank accession No. ) NM_004420 (DUSP8, Dual specificity phosphatase 8), gene accession number (GeneBank accession No. ) L11329 (DUSP2, Dual specificity phosphatase 2), gene accession number (GeneBank accession No. ) BC094766 (PKN1, Protein kinase N1), gene accession number (GeneBank accession No. ) AY247738 (TRIB3, Tribbles homolog 3 (Drosophila)), gene accession number (GeneBank accession No. ) AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), Gene Accession No. ) AB208849 (SHC1, Src homology 2 domain containing (SHC) transforming protein 1), gene accession number (GeneBank accession No. ) X02812 (TGFB1, Transforming growth factor, beta 1 (Camurati-Engelmann disease)), Gene Accession No. ) NM_198951 (TGM2, Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)), gene registration number (GeneBank accession No. NM_147780 (CTSB, Cathepsin B), gene accession number (GeneBank accession No. NM_078467 (CDKN1A, Cyclin-dependent kinase inhibitor 1A (p21, Cip1)), gene accession number (GeneBank accession No. NM_033027 (AXUD1, AXIN1 up-regulated 1), gene accession number (GeneBank accession No. NM_032797 (AMID, Apoptosis-inducing factor (AIF) -like mitochondrion-associated inducer of death), GeneBank accession No. ) NM_021960 (MCL1, Myeloid cell leukemia sequence 1 (BCL2-related)), gene registration number (GeneBank accession No. ) NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), gene accession number (GeneBank accession No. ) NM_016222 (DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41), gene accession number (GeneBank accession No. ) NM_013246 (CLC, Cardiotrophin-like cytokine factor 1), gene accession number (GeneBank accession No. ) NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), gene registration number (GeneBank accession No. ) NM_004281 (BAG3, BCL2-associated athanogene 3), gene accession number (GeneBank accession No. ) NM_003897 (IER3, Immediate early response 3), Gene accession number (GeneBank accession No. ) NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), gene accession number (GeneBank accession No. ) NM_003639 (IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No. ) NM_003311 (PHLDA2, Pleckstrin homology-like domain, family A, member 2), gene accession number (GeneBank accession No. ) NM_002737 (PRKCA, Protein Kinase C, alpha), Gene Accession Number (GeneBank accession No. NM_002648 (PIM1, Pim-1 oncogene), gene accession number (GeneBank accession No. NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), gene accession number (GeneBank accession No. ) NM_002305 (LGALS1, Lectin, galactoside-binding, soluble, 1 (galectin 1)), gene accession number (GeneBank accession No. ) NM_001013398 (IGFBP3, Insulin-like growth factor binding protein 3), gene registration number (GeneBank accession No. ) BX640923 (MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)), gene accession number (GeneBank accession No. ) BX537586 (STK17A, Serine / threonine kinase 17a (apoptosis-inducing)), gene accession number (GeneBank accession No. ) BG284742 (P8, P8 protein (candidate of metastasis 1)), gene accession number (GeneBank accession No. ) BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), gene accession number (GeneBank accession No. ) BC027949 (P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), gene accession number (GeneBank accession No. ) BC006365 (PSEN2, Presenilin 2 (Alzheimer disease 4)), gene accession number (GeneBank accession No. ) AY869712 (PPP1R13L, Protein phosphatase 1, regulatory (inhibitor) subunit 13 like), Gene Accession No. ) AY028896 (CARD10, Caspase recruitment domain family, member 10), gene accession number (GeneBank accession No. ) AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), gene accession number (GeneBank accession No. ) AK092872 (ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), gene registration number (GeneBank accession No. ) AK092808 (RRAGC, Ras-related GTP binding C), gene accession number (GeneBank accession No. ) AJ001898 (GDNF, Glial cell derived neurotrophic factor), gene accession number (GeneBank accession No. ) AF220656 (PHLDA1, Pleckstrin homology-like domain, family A, member 1), gene accession number (GeneBank accession No. AF055634 (UNC5C, Unc-5 homolog C (C.  elegans), GeneBank accession No. ) AB209485 (Vescular endothelial growth factor), gene accession number (GeneBank accession No. ) AB096256 (UNC5B, Unc-5 homolog B (C.  elegans), GeneBank accession No. ) AB007960 (SH3GLB1, SH3-domain GRB2-like endophilin B1), gene accession number (GeneBank accession No. ) X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), Gene accession number (GeneBank accession No. ) S62138 (DDIT3, DNA-damage-inducible transcript 3), gene accession number (GeneBank accession No. NM_078487 (CDKN2B, Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)), gene accession number (GeneBank accession No. ) NM_012127 (CIZ1, CDKN1A interacting zinc finger protein 1), gene accession number (GeneBank accession No. ) NM_005883 (APC2, Adenomatosis polyposis coli 2), gene accession number (GeneBank accession No. ) NM_004196 (CDKL1, Cyclin-dependent kinase-like 1 (CDC2-related kinase)), gene accession number (GeneBank accession No. ) NM_003236 (TGFA, Transforming growth factor, alpha), gene registration number (GeneBank accession No. ) NM_001261 (CDK9, Cyclin-dependent kinase 9 (CDC2-related kinase)), gene accession number (GeneBank accession No. ) NM_001007271 (DUSP13, Dual specificity phosphatase 13), gene accession number (GeneBank accession No. ) CR749511 (PARC, P53-associated parkin-like cytoplasmic protein), gene registration number (GeneBank accession No. CR623038 (ID2, Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), gene accession number (GeneBank accession No. CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No. ) BF965144 (IFITM1, Interferon induced transmembrane protein 1 (9-27)), gene accession number (GeneBank accession No. ) AK127679 (DUSP1, Dual specificity phosphatase 1), gene accession number (GeneBank accession No. ) AK096276 (CCND3, Cyclin D3), gene accession number (GeneBank accession No. ) AB209586 (MAPK13, Mitogen-activated protein kinase 13), gene accession number (GeneBank accession No. ) AB209465 (PCTK1, PCTAIRE protein kinase 1), gene accession number (GeneBank accession No. ) Z19588 (SKIL, SKI-like), gene accession number (GeneBank accession No. NM_020429 (SMURF1, SMAD specific E3 ubiquitin protein ligase 1), gene accession number (GeneBank accession No. ) NM_014767 (SPOCK2, Sparc / osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), Gene Accession No. ) NM_005979 (S100A13, S100 calcium binding protein A13), gene registration number (GeneBank accession No. NM_005187 (CBFA2T3, Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), gene accession number (GeneBank accession No. ) NM_004364 (CEBPA, CCAAT / enhancer binding protein (C / EBP), alpha), gene registration number (GeneBank accession No. ) NM_001769 (CD9, CD9 antigen (p24)), gene accession number (GeneBank accession No. ) NM_001718 (BMP6, Bone morphogenetic protein 6), gene accession number (GeneBank accession No. ) NM_000641 (IL11, Interleukin 11), gene accession number (GeneBank accession No. ) BX647459 (SERPINE2, Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2), gene registration number (GeneBank accession No. ) BQ066037 (RPS19, Ribosomal protein S19), gene accession number (GeneBank accession No. ) BE791300 (EDF1, Endothelial differentiation-related factor 1), Gene accession number (GeneBank accession No. ) BC038504 (SNF1LK, SNF1-like kinase), gene accession number (GeneBank accession No. ) AL832287 (ZAP70, Zeta-chain (TCR) associated protein kinase 70kDa), gene accession number (GeneBank accession No. ) AK125742 (PCGF1, Polycomb group ring finger 1), gene accession number (GeneBank accession No. ) AK124709 (NDRG1, N-myc downstream regulated gene 1), gene accession number (GeneBank accession No. ) AB011157 (PTDSR, Phosphatidylserine receptor), Gene Accession No. NM_013255 (MKLN1, Muskelin 1, intracellular mediator containing kelch motifs), gene accession number (GeneBank accession No. ) NM_006572 (GNA13, Guanine nucleotide binding protein (G protein), alpha 13), gene registration number (GeneBank accession No. NM_002211 (ITGB1, Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)), gene accession number (GeneBank accession No. ) CR601067 (PLAUR, Plasminogen activator, urokinase receptor), gene accession number (GeneBank accession No. ) BC050456 (THBS4, Thrombospondin 4), gene registration number (GeneBank accession No. ) AK027389 (CXCL16, Chemokine (C-X-C motif) ligand 16), gene accession number (GeneBank accession No. ) AJ132099 (VNN1, Vanin 1), gene accession number (GeneBank accession No. ) XM_371354 (FLJ10157, Hypothetical protein FLJ10157), gene accession number (GeneBank accession No. ) XM_208313 (TPM3, Similar to tropomyosin 4), gene accession number (GeneBank accession No. XM_208270 (ACR, Acrosin-like protease), gene accession number (GeneBank accession No. ) NM_203353 (PDLIM7, PDZ and LIM domain 7 (enigma)), gene accession number (GeneBank accession No. ) NM_201382 (PLEC1, Plectin 1, intermediate filament binding protein 500kDa), gene registration number (GeneBank accession No. ) NM_182961 (SYNE1, Spectrin repeat containing, nuclear envelope 1), gene accession number (GeneBank accession No. ) NM_181826 (NF2, Neurofibromin 2 (bilateral acoustic neuroma)), gene accession number (GeneBank accession No. NM_172069 (PLEKHH2, Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2), gene accession number (GeneBank accession No. ) NM_022648 (TNS, Tensin 1), gene accession number (GeneBank accession No. NM_017556 (FBLP-1, Filamin binding LIM protein 1), gene accession number (GeneBank accession No. NM_016081 (KIAA0992, Palladin, cytoskeletal associated protein), gene accession number (GeneBank accession No. ) NM_006617 (NES, Nestin), gene accession number (GeneBank accession No. ) NM_006262 (PRPH, Peripherin), gene accession number (GeneBank accession No. NM_005100 (AKAP12, A kinase (PRKA) anchor protein (gravin) 12), gene registration number (GeneBank accession No. NM_004368 (CNN2, Calponin 2), gene accession number (GeneBank accession No. ) NM_003388 (CYLN2, Cytoplasmic linker 2), gene accession number (GeneBank accession No. ) NM_003370 (VASP, Vasodilator-stimulated phosphoprotein), gene accession number (GeneBank accession No. ) NM_003128 (SPTBN1, Spectrin, beta, non-erythrocytic 1), gene accession number (GeneBank accession No. ) NM_002705 (PPL, Periplakin), gene accession number (GeneBank accession No. ) NM_002475 (MLC1SA, Myosin light chain 1 slow a), Gene accession number (GeneBank accession No. ) NM_002018 (FLII, Flightless I homolog (Drosophila)), Gene Accession Number (GeneBank accession No. ) NM_001465 (FYB, FYN binding protein (FYB-120 / 130)), gene registration number (GeneBank accession No. NM_001069 (TUBB2, Tubulin, beta 2A), gene accession number (GeneBank accession No. ) CR625172 (MGC8685, Tubulin, beta 2B), gene accession number (GeneBank accession No. CR616919 (KRT18, Keratin 18), gene accession number (GeneBank accession No. ) CR606241 (ACTG1, Actin, gamma 1), gene accession number (GeneBank accession No. ) CB240572 (MYH11, Myosin, heavy polypeptide 11, smooth muscle), gene accession number (GeneBank accession No. ) BX648253 (PTPN3, Protein tyrosine phosphatase, non-receptor type 3), Gene accession number (GeneBank accession No. ) BX648190 (WDR1, WD repeat domain 1), Gene accession number (GeneBank accession No. ) BX641076 (ACTN1, Actinin, alpha 1), gene accession number (GeneBank accession No. ) BX537978 (EPB41L1, Erythrocyte membrane protein band 4. 1-like 1), gene accession number (GeneBank accession No. ) BG121847 (NUDC, Nuclear distribution gene C homolog (A.  nidulans)), and GeneBank accession No. ) BC068013 (MYO1C, Myosin IC), gene accession number (GeneBank accession No. ) BC065499 (MAST2, Microtubule associated serine / threonine kinase 2), gene accession number (GeneBank accession No. ) BC051890 (TUBG2, Tubulin, gamma 2), gene accession number (GeneBank accession No. ) BC041874 (MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), gene accession number (GeneBank accession No. ) BC012597 (ACTA1, Actin, alpha 1, skeletal muscle), gene accession number (GeneBank accession No. ) AY484427 (KIF17, Kinesin family member 17), gene accession number (GeneBank accession No. ) AK130546 (STOML2, Stomatin (EPB72) -like 2), Gene accession number (GeneBank accession No. ) AK124711 (CORO2B, Coronin, actin binding protein, 2B), gene accession number (GeneBank accession No. ) AK123974 (MYL5, Myosin, light polypeptide 5, regulatory), gene accession number (GeneBank accession No. ) AK092792 (LOC389833, Similar to hypothetical protein MGC27019), gene accession number (GeneBank accession No. ) AK026518 (MYOHD1, Myosin head domain containing 1), gene accession number (GeneBank accession No. ) AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), gene accession number (GeneBank accession No. ) AF085886 (FLJ46675, Ribosomal protein L29 pseudogene 2), gene accession number (GeneBank accession No. ) AB209997 (MYO9B, Myosin IXB), gene accession number (GeneBank accession No. Y12692 (WNT11, Wingless-type MMTV integration site family, member 11), gene accession number (GeneBank accession No. ) Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), gene accession number (GeneBank accession No. X17033 (ITGA2, Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)), gene accession number (GeneBank accession No. ) U41763 (CLTCL1, Clathrin, heavy polypeptide-like 1), gene accession number (GeneBank accession No. NM_153609 (TMPRSS6, Transmembrane protease, serine 6), gene accession number (GeneBank accession No. ) NM_031483 (ITCH, Itchy homolog E3 ubiquitin protein ligase (mouse)), gene accession number (GeneBank accession No. ) NM_024342 (GRLF1, Glucocorticoid receptor DNA binding factor 1), gene accession number (GeneBank accession No. NM_017555 (EGLN2, Egl nine homolog 2 (C.  elegans), GeneBank accession No. NM_016569 (TBX3, T-box 3 (ulnar mammary syndrome)), gene accession number (GeneBank accession No. NM_004148 (NINJ1, Ninjurin 1), gene accession number (GeneBank accession No. ) NM_003377 (VEGFB, Vascular endothelial growth factor B), gene accession number (GeneBank accession No. ) NM_001983 (ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)), GeneBank accession No. ) NM_001552 (IGFBP4, Insulin-like growth factor binding protein 4), gene registration number (GeneBank accession No. ) NM_001430 (EPAS1, Endothelial PAS domain protein 1), Gene accession number (GeneBank accession No. NM_001300 (KLF6, Kruppel-like factor 6), gene accession number (GeneBank accession No. ) NM_001012661 (SLC3A2, Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), gene accession number (GeneBank accession No. NM_000596 (IGFBP1, Insulin-like growth factor binding protein 1), gene registration number (GeneBank accession No. ) NM_000474 (TWIST1, Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)), Gene Accession No. ) BX649103 (ChGn, Chondroitin beta1,4 N-acetylgalactosaminyltransferase), Gene Accession No. ) BM913048 (TIMP1, TIMP metallopeptidase inhibitor 1), gene accession number (GeneBank accession No. ) BM904612 (S100A6, S100 calcium binding protein A6 (calcyclin)), gene accession number (GeneBank accession No. ) BM556279 (EMP3, Epithelial membrane protein 3), gene accession number (GeneBank accession No. ) BC015041 (VAT1, Family with sequence similarity 82, member C), gene accession number (GeneBank accession No. ) AY258066 (OKL38, Pregnancy-induced growth inhibitor), gene accession number (GeneBank accession No. ) AK126729 (NDRG4, NDRG family member 4), gene accession number (GeneBank accession No. ) AK090459 (NFE2L1, Nuclear factor (erythroid-derived 2) -like 1), gene accession number (GeneBank accession No. ) AK074163 (ROBO4, Roundabout homolog 4, magic roundabout (Drosophila)), Gene accession number (GeneBank accession No. ) AK024680 (FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), gene accession number (GeneBank accession No. ) AF176422 (HEY1, Hairy / enhancer-of-split related with YRPW motif 1), gene accession number (GeneBank accession No. ) AF003837 (JAG1, Jagged 1 (Alagille syndrome)), gene accession number (GeneBank accession No. ) AB209322 (SEMA3B, Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B), GeneBank accession No. ) AB011150 (NRXN1, Neurexin 1), gene accession number (GeneBank accession No. ) NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)), gene accession number (GeneBank accession No. NM_052999 (CKLFSF1, CKLF-like MARVEL transmembrane domain containing 1), gene accession number (GeneBank accession No. NM_006644 (HSPH1, Heat shock 105kDa / 110kDa protein 1), gene registration number (GeneBank accession No. NM_005438 (FOSL1, FOS-like antigen 1), gene accession number (GeneBank accession No. ) NM_004996 (ABCC1, ATP-binding cassette, sub-family C (CFTR / MRP), member 1), gene accession number (GeneBank accession No. ) NM_002658 (PLAU, Plasminogen activator, urokinase), gene accession number (GeneBank accession No. ) NM_001353 (AKR1C1, Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha) -hydroxysteroid dehydrogenase)), gene accession number (GeneBank accession No. ) H18681 (C20orf139, Sulfiredoxin 1 homolog (S.  cerevisiae)), gene accession number (GeneBank accession No. ) DR004094 (HAMP, Hepcidin antimicrobial peptide), gene accession number (GeneBank accession No. ) BC082272 (KCNMB3, Potassium large conductance calcium-activated channel, subfamily M beta member 3), Gene Accession No. ) BC040494 (DNAJB2, DnaJ (Hsp40) homolog, subfamily B, member 2), gene registration number (GeneBank accession No. ) BC018064 (ATF6, Activating transcription factor 6), gene accession number (GeneBank accession No. ) BC006523 (SGK2, Serum / glucocorticoid regulated kinase 2), gene registration number (GeneBank accession No. ) AK090482 (CXCL12, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)), gene accession number (GeneBank accession No. ) AF219946 (TULP4, Tubby like protein 4), gene accession number (GeneBank accession No. ) AB209112 (SLC2A8, Solute carrier family 2, (facilitated glucose transporter) member 8), gene accession number (GeneBank accession No. ) NM_005242 (F2RL1, Coagulation factor II (thrombin) receptor-like 1), gene accession number (GeneBank accession No. ) NM_001002029 (C4A, Complement component 4B, telomeric), Gene accession number (GeneBank accession No. ) NM_000539 (RHO, Rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)), gene accession number (GeneBank accession No. ) BX649164 (PAI, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), gene registration number (GeneBank accession No. ) BM918324 (LY96, Lymphocyte antigen 96), gene accession number (GeneBank accession No. ) AB209647 (NCF2, Neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2)), gene accession number (GeneBank accession No. ) NM_152221 (CSNK1E, Casein kinase 1, epsilon), Gene accession number (GeneBank accession No. ) NM_017999 (RNF31, Ring finger protein 31), gene accession number (GeneBank accession No. ) NM_016819 (OGG1, 8-oxoguanine DNA glycosylase), Gene Accession No. ) NM_016816 (OAS1, 2 ', 5'-oligoadenylate synthetase 1, 40 / 46kDa), Gene Accession No. NM_012235 (SCAP, SREBP cleavage-activating protein), gene accession number (GeneBank accession No. ) NM_006384 (CIB1, Calcium and integrin binding 1 (calmyrin)), gene accession number (GeneBank accession No. ) NM_001779 (CD58, CD58 antigen, (lymphocyte function-associated antigen 3)), gene accession number (GeneBank accession No. ) CB055213 (ICOSLG, Inducible T-cell co-stimulator ligand), Gene accession number (GeneBank accession No. ) BX641029 (MASP1, Mannan-binding lectin serine peptidase 1 (C4 / C2 activating component of Ra-reactive factor)), GeneBank accession No. ) BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), Gene Accession No. ) BC039299 (STIP1, Stress-induced-phosphoprotein 1 (Hsp70 / Hsp90-organizing protein)), gene accession number (GeneBank accession No. ) AY055760 (DAF, Decay accelerating factor for complement (CD55, Cromer blood group system)), gene accession number (GeneBank accession No. ) AK130188 (FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog), Gene Accession No. ) AK095326 (MUS81, MUS81 endonuclease homolog (yeast)), gene accession number (GeneBank accession No. NM_017670 (OTUB1, OTU domain, ubiquitin aldehyde binding 1), gene registration number (GeneBank accession No. ) NM_003004 (SECTM1, Secreted and transmembrane 1), gene accession number (GeneBank accession No. ) NM_002309 (LIF, Hypothetical protein MGC20647), gene accession number (GeneBank accession No. ) NM_001421 (ELF4, E74-like factor 4 (ets domain transcription factor)), gene accession number (GeneBank accession No. ) NM_000418 (IL4R, Interleukin 4 receptor), gene accession number (GeneBank accession No. ) BI909222 (FCER1G, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), gene accession number (GeneBank accession No. ) BF569086 (NK4, Interleukin 32), gene accession number (GeneBank accession No. ) BC014470 (AZGP1, Alpha-2-glycoprotein 1, zinc), gene accession number (GeneBank accession No. ) BC020744 (AKR1C4, Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol), dehydrogenase 4), gene accession number (GeneBank accession No. ) BQ939577 (AKR1C3, Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)), gene accession number (GeneBank accession No. ) NM_000499 (CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), gene accession number (GeneBank accession No. ) NM_030622 (CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), gene accession number (GeneBank accession No. ) NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate), gene accession number (GeneBank accession No. ) NM_024307 (MGC4171, Hypothetical protein LOC283901), gene accession number (GeneBank accession No. ) NM_005336 (HDLBP, High density lipoprotein binding protein (vigilin)), gene registration number (GeneBank accession No. ) NM_002627 (PFKP, Phosphofructokinase, platelet), Gene Registration Number (GeneBank accession No. ) BX648281 (LDLR, low density lipoprotein receptor (familial hypercholesterolemia)), gene accession number (GeneBank accession No. ) BC069201 (FLJ22761, Hexokinase domain containing 1), gene accession number (GeneBank accession No. ) BC030207 (NR0B2, Nuclear receptor subfamily 0, group B, member 2), gene accession number (GeneBank accession No. ) AL833069 (KIAA1434, Hypothetical protein KIAA1434), gene accession number (GeneBank accession No. ) AK124656 (ENO2, Enolase 2 (gamma, neuronal)), gene accession number (GeneBank accession No. ) AK094474 (RHOC, Ras homolog gene family, member C), gene accession number (GeneBank accession No. ) AK093461 (ISYNA1, Myo-inositol 1-phosphate synthase A1), gene accession number (GeneBank accession No. ) AB053232 (GAL3ST3, Galactose-3-O-sulfotransferase 3), gene accession number (GeneBank accession No. ) AB045292 (TMEM8, Transmembrane protein 8 (five membrane-spanning domains)), gene accession number (GeneBank accession No. ) NM_004753 (DHRS3, Dehydrogenase / reductase (SDR family) member 3), Gene accession number (GeneBank accession No. ) NM_002900 (RBP3, Retinol binding protein 3, interstitial), gene accession number (GeneBank accession No. ) NM_001995 (ACSL1, Acyl-CoA synthetase long-chain family member 1), gene accession number (GeneBank accession No. NM_000018 (ACADVL, Acyl-Coenzyme A dehydrogenase, very long chain), gene accession number (GeneBank accession No. ) BC094756 (CRA, Myotubularin related protein 11), gene accession number (GeneBank accession No. ) BC050553 (NTE, Neuropathy target esterase), gene accession number (GeneBank accession No. ) BC033110 (HSD17B1, Hydroxysteroid (17-beta) dehydrogenase 1), Gene accession number (GeneBank accession No. ) AY268890 (TPP1, Tripeptidyl peptidase I), gene accession number (GeneBank accession No. ) AK172798 (CPT1A, Carnitine palmitoyltransferase 1A (liver)), gene accession number (GeneBank accession No. ) AK096809 (CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), gene accession number (GeneBank accession No. ) AK000600 (SIAT7D, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) -N-acetylgalactosaminide alpha-2,6-sialyltransferase 4), Gene accession number ) AB002454 (CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), gene accession number (GeneBank accession No. ) Z29093 (DDR1, Discoidin domain receptor family, member 1), gene accession number (GeneBank accession No. ) Z25424 (MKNK2, MAP kinase interacting serine / threonine kinase 2), gene accession number (GeneBank accession No. ) XM_291277 (DKFZp761P0423, Hypothetical protein DKFZp761P0423), gene accession number (GeneBank accession No. XM_038150 (MAST3, Microtubule associated serine / threonine kinase 3), gene accession number (GeneBank accession No. ) U88357 (ERBB3, V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)), gene accession number (GeneBank accession No. ) NM_025195 (TRIB1, Tribbles homolog 1 (Drosophila)), gene accession number (GeneBank accession No. ) NM_020639 (RIPK4, Receptor-interacting serine-threonine kinase 4), gene accession number (GeneBank accession No. ) NM_014172 (PHPT1, Phosphohistidine phosphatase 1), Gene accession number (GeneBank accession No. ) NM_006254 (PRKCD, Protein kinase C, delta), Gene accession number (GeneBank accession No. ) NM_005415 (SLC20A1, Solute carrier family 20 (phosphate transporter), member 1), gene accession number (GeneBank accession No. ) NM_005026 (PIK3CD, Phosphoinositide-3-kinase, catalytic, delta polypeptide), Gene accession number (GeneBank accession No. ) NM_004431 (EPHA2, EPH receptor A2), gene accession number (GeneBank accession No. ) NM_004419 (DUSP5, Dual specificity phosphatase 5), gene accession number (GeneBank accession No. ) NM_004327 (BCR, Breakpoint cluster region), Gene accession number (GeneBank accession No. ) NM_004231 (ATP6V1F, ATPase, H + transporting, lysosomal 14kDa, V1 subunit F), gene registration number (GeneBank accession No. ) NM_004090 (DUSP3, Dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)), gene accession number (GeneBank accession No. ) NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), gene accession number (GeneBank accession No. NM_002496 (NDUFS8, NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase)), gene accession number (GeneBank accession No. NM_001001852 (PIM3, Pim-3 oncogene), gene accession number (GeneBank accession No. ) L76191 (IRAK1, Interleukin-1 receptor-associated kinase 1), gene accession number (GeneBank accession No. ) D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), gene accession number (GeneBank accession No. ) BC065207 (ATP6V0D2, ATPase, H + transporting, lysosomal 38kDa, V0 subunit d isoform 2), gene accession number (GeneBank accession No. ) BC035578 (STK24, Serine / threonine kinase 24 (STE20 homolog, yeast)), gene accession number (GeneBank accession No. ) BC028724 (DUSP18, Dual specificity phosphatase 18), gene accession number (GeneBank accession No. AL117482 (ULK3, Unc-51-like kinase 3 (C.  elegans), GeneBank accession No. ) AK126879 (PCTK3, PCTAIRE protein kinase 3), gene accession number (GeneBank accession No. ) AB209416 (ILK, Integrin-linked kinase-2), gene accession number (GeneBank accession No. ) NM_000782 (CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1), gene accession number (GeneBank accession No. ) CR597101 (ZFP36, Zinc finger protein 36, C3H type, homolog (mouse)), Gene accession number (GeneBank accession No. ) CR936799 (FHL2, Four and a half LIM domains 2), gene accession number (GeneBank accession No. ) M24898 (NR1D1, Nuclear receptor subfamily 1, group D, member 1), gene accession number (GeneBank accession No. ) AF132818 (KLF5, Kruppel-like factor 5 (intestinal)), gene accession number (GeneBank accession No. ) AK055337 (ZNF213, Zinc finger protein 213), Gene accession number (GeneBank accession No. ) BC008834 (PHF1, PHD finger protein 1), gene accession number (GeneBank accession No. ) AK126918 (GLIS2, GLIS family zinc finger 2), Gene accession number (GeneBank accession No. ) BC042692 (CTL2, Solute carrier family 44, member 2), gene accession number (GeneBank accession No. ) NM_002224 (ITPR3, Inositol 1,4,5-triphosphate receptor, type 3), gene accession number (GeneBank accession No. ) AK095363 (AQP3, Aquaporin 3), gene accession number (GeneBank accession No. NM_174953 (ATP2A3, ATPase, Ca ++ transporting, ubiquitous), gene accession number (GeneBank accession No. ) BC042390 (VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B (yeast)), GeneBank Accession No. NM_016113 (TRPV2, Transient receptor potential cation channel, subfamily V, member 2), gene accession number (GeneBank accession No. ) BM926478 (RBP1, Retinol binding protein 1, cellular), gene accession number (GeneBank accession No. NM_000069 (CACNA1S, Calcium channel, voltage-dependent, L type, alpha 1S subunit), Gene Registration Number (GeneBank accession No. ) AK002107 (RAB3B, RAB3B, member RAS oncogene family), gene accession number (GeneBank accession No. ) NM_013321 (SNX8, Sorting nexin 8), Gene accession number (GeneBank accession No. ) AK125026 (SLC6A12, Solute carrier family 6 (neurotransmitter transporter, betaine / GABA), member 12), gene accession number (GeneBank accession No. ) NM_005843 (STAM2, Signal transducing adapter molecule (SH3 domain and ITAM motif) 2), gene accession number (GeneBank accession No. ) AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), gene accession number (GeneBank accession No. ) U49248 (ABCC2, ATP-binding cassette, sub-family C (CFTR / MRP), member 2), gene accession number (GeneBank accession No. ) AK172792 (SCNN1A, Sodium channel, nonvoltage-gated 1 alpha), gene accession number (GeneBank accession No. ) BC044656 (CASC3, Cancer susceptibility candidate 3), gene accession number (GeneBank accession No. NM_203403 (C9orf150, Chromosome 9 open reading frame 150), gene accession number (GeneBank accession No. NM_080388 (S100A16, S100 calcium binding protein A16), gene registration number (GeneBank accession No. NM_031286 (SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), gene accession number (GeneBank accession No. NM_022153 (PP2135, Chromosome 10 open reading frame 54), gene accession number (GeneBank accession No. ) NM_004864 (GDF15, Growth differentiation factor 15), Gene accession number (GeneBank accession No. ) NM_003330 (TXNRD1, Thioredoxin reductase 1), gene accession number (GeneBank accession No. ) NM_001013632 (LOC343521, Similar to hypothetical protein 4833401D15), gene accession number (GeneBank accession No. ) BX537968 (LOC51149, Hypothetical LOC51149), gene accession number (GeneBank accession No. BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), gene accession number (GeneBank accession No. ) BQ683841 (S100A11, S100 calcium binding protein A11 (calgizzarin)), gene accession number (GeneBank accession No. ) BQ276852 (TMSB10, Thymosin, beta 10), gene accession number (GeneBank accession No. ) AK126182 (KIAA1949, KIAA1949), gene accession number (GeneBank accession No. ) AK124751 (CAPN2, Calpain 2, (m / II) large subunit), gene accession number (GeneBank accession No. ) AK095079 (RGC32, Response gene to complement 32), gene accession number (GeneBank accession No. ) AB075871 (FLJ42654, Golgi transport 1 homolog A (S.  cerevisiae)), gene accession number (GeneBank accession No. ) AK125150 (MAPK8, Mitogen-activated protein kinase 8), gene registration number (GeneBank accession No. ) NM_002758 (MAP2K6, Mitogen-activated protein kinase kinase 6), gene accession number (GeneBank accession No. ) NM_004612 (TGFBR1, Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kDa)), gene accession number (GeneBank accession No. NM_145686 (MAP4K4, Mitogen-activated protein kinase kinase kinase kinase 4), gene accession number (GeneBank accession No. ) XM_042066 (MAP3K1, Mitogen-activated protein kinase kinase kinase 1), gene accession number (GeneBank accession No. ) AB011123 (TNIK, TRAF2 and NCK interacting kinase), gene accession number (GeneBank accession No. ) AB209031 (C5, Complement component 5), gene accession number (GeneBank accession No. NM_022740 (HIPK2, Homeodomain interacting protein kinase 2), gene accession number (GeneBank accession No. ) NM_148957 (TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), gene accession number (GeneBank accession No. ) AB208909 (ITGB2, Integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)), GeneBank accession No. ) AB209211 (TIA1, TIA1 cytotoxic granule-associated RNA binding protein), gene accession number (GeneBank accession No. ) AB209613 (DNASE1L3, Deoxyribonuclease I-like 3), Gene accession number (GeneBank accession No. ) AK122825 (HMGB1, High-mobility group box 1), gene accession number (GeneBank accession No. ) AK127326 (PHF17, PHD finger protein 17), gene accession number (GeneBank accession No. ) AK223503 (CASP1, Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)), gene accession number (GeneBank accession No. ) BC013326 (GAS2, Growth arrest-specific 2), Gene accession number (GeneBank accession No. ) BC047698 (IL7, Interleukin 7), gene accession number (GeneBank accession No. D79987 (ESPL1, Extra spindle poles like 1 (S.  cerevisiae)), gene accession number (GeneBank accession No. ) NM_000893 (KNG1, Kininogen 1), gene accession number (GeneBank accession No. ) NM_001012271 (BIRC5, Effector cell peptidase receptor 1), gene accession number (GeneBank accession No. ) NM_004938 (DAPK1, Death-associated protein kinase 1), gene accession number (GeneBank accession No. NM_005879 (TRIP, TRAF interacting protein), gene accession number (GeneBank accession No. NM_014739 (BCLAF1, BCL2-associated transcription factor 1), gene accession number (GeneBank accession No. ) NM_018947 (CYCS, Cytochrome c, somatic), Gene accession number (GeneBank accession No. ) AB033337 (MPHOSPH1, M-phase phosphoprotein 1), gene accession number (GeneBank accession No. ) AB209179 (PLK1, Polo-like kinase 1 (Drosophila)), gene accession number (GeneBank accession No. ) AB209337 (CDC7, CDC7 cell division cycle 7 (S.  cerevisiae)), gene accession number (GeneBank accession No. ) AF053305 (BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)), gene accession number (GeneBank accession No. ) AF053306 (BUB1B, BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)), Gene Accession No. ) AF345347 (SPAG5, Sperm associated antigen 5), gene accession number (GeneBank accession No. ) AK092638 (CCNG2, Cyclin G2), gene accession number (GeneBank accession No. ) AK222819 (NUSAP1, Nucleolar and spindle associated protein 1), gene accession number (GeneBank accession No. ) AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1 (yeast)), gene accession number (GeneBank accession No. ) AY257469 (CIT, Citron (rho-interacting, serine / threonine kinase 21)), gene accession number (GeneBank accession No. ) AY367065 (ASPM, Abnormal Spindle-like, microcephaly associated (Drosophila)), GeneBank Accession No. ) BC011000 (CDCA5, Cell division cycle associated 5), gene accession number (GeneBank accession No. ) BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), gene accession number (GeneBank accession No. ) BC043502 (NEK2, never in mitosis gene a) -related kinase 2), gene accession number (GeneBank accession No. BU675073 (PTTG1, Pituitary tumor-transforming 1), gene accession number (GeneBank accession No. ) BX647885 (STMN1, Stathmin 1 / oncoprotein 18), gene accession number (GeneBank accession No. ) CR592757 (BRRN1, Barren homolog 1 (Drosophila)), gene accession number (GeneBank accession No. CR597075 (MAPRE2, Microtubule-associated protein, RP / EB family, member 2), gene accession number (GeneBank accession No. ) CR604810 (CCNA2, Cyclin A2), gene accession number (GeneBank accession No. CR933728 (CDC2, Cell division cycle 2, G1 to S and G2 to M), Gene accession number (GeneBank accession No. ) NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase), gene accession number (GeneBank accession No. ) NM_001790 (CDC25C, Cell division cycle 25C), Gene accession number (GeneBank accession No. NM_001798 (CDK2, Cyclin-dependent kinase 2), gene accession number (GeneBank accession No. ) NM_001813 (CENPE, Centromere protein E, 312kDa), Gene accession number (GeneBank accession No. ) NM_003318 (TTK, TTK protein kinase), gene accession number (GeneBank accession No. ) NM_003981 (PRC1, Protein regulator of cytokinesis 1), gene accession number (GeneBank accession No. NM_004523 (KIF11, Kinesin family member 11), gene accession number (GeneBank accession No. ) NM_004701 (CCNB2, Cyclin B2), gene accession number (GeneBank accession No. ) NM_005983 (SKP2, S-phase kinase-associated protein 2 (p45)), gene accession number (GeneBank accession No. NM_006101 (KNTC2, Kinetochore associated 2), gene accession number (GeneBank accession No. ) NM_006845 (KIF2C, Kinesin family member 2C), gene accession number (GeneBank accession No. ) NM_007375 (TARDBP, TAR DNA binding protein), gene registration number (GeneBank accession No. ) NM_012112 (TPX2, TPX2, microtubule-associated, homolog (Xenopus laevis)), gene accession number (GeneBank accession No. ) NM_014750 (DLG7, Discs, large homolog 7 (Drosophila)), gene accession number (GeneBank accession No. ) NM_015097 (CLASP2, Cytoplasmic linker associated protein 2), gene accession number (GeneBank accession No. ) NM_016343 (CENPF, Centromere protein F, 350 / 400ka (mitosin)), gene accession number (GeneBank accession No. NM_016426 (GTSE1, G-2 and S-phase expressed 1), gene accession number (GeneBank accession No. ) NM_018492 (PBK, PDZ binding kinase), gene accession number (GeneBank accession No. NM_018685 (ANLN, Anillin, actin binding protein (scraps homolog, Drosophila)), gene accession number (GeneBank accession No. ) NM_020242 (KNSL7, Kinesin family member 15), gene accession number (GeneBank accession No. ) NM_031966 (CCNB1, Cyclin B1), gene accession number (GeneBank accession No. NM_138555 (KIF23, Kinesin family member 23), gene accession number (GeneBank accession No. ) U65410 (MAD2L1, MAD2 mitotic arrest deficient-like 1 (yeast)), gene accession number (GeneBank accession No. ) AB020656 (CYLD, Cylindromatosis (turban tumor syndrome)), Gene Accession Number (GeneBank accession No. ) AF033122 (SESN1, Sestrin 1), gene accession number (GeneBank accession No. ) AK074377 (UHRF1, Chromosome 19 open reading frame 31), gene accession number (GeneBank accession No. ) AK091170 (CDKN2C, Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)), gene accession number (GeneBank accession No. ) AK094323 (NFYC, Nuclear transcription factor Y, gamma), gene accession number (GeneBank accession No. ) AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No. ) BC033086 (TCF19, Transcription factor 19 (SC1)), gene accession number (GeneBank accession No. ) BC040303 (PTP4A1, Protein tyrosine phosphatase type IVA, member 1), Gene accession number (GeneBank accession No. ) BC040991 (TFDP2, Transcription factor Dp-2 (E2F dimerization partner 2)), gene accession number (GeneBank accession No. BC092412 (SGOL2, Shugoshin-like 2 (S.  pombe), GeneBank accession No. ) BQ278454 (CKS1B, CDC28 protein kinase regulatory subunit 1B), gene accession number (GeneBank accession No. ) BX649128 (SESN3, Sestrin 3), gene accession number (GeneBank accession No. ) CD049340 (AURKB, Aurora kinase B), gene accession number (GeneBank accession No. ) M89914 (NF1, Neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)), gene accession number (GeneBank accession No. NM_001005414 (ZWINT, ZW10 interactor antisense), gene accession number (GeneBank accession No. ) NM_001008491 (Sep 2, Septin 2), gene accession number (GeneBank accession No. NM_001274 (CHEK1, CHK1 checkpoint homolog (S.  pombe), GeneBank accession No. NM_002105 (H2AFX, H2A histone family, member X), gene accession number (GeneBank accession No. NM_002388 (MCM3, MCM3 minichromosome maintenance deficient 3 (S.  cerevisiae)), gene accession number (GeneBank accession No. NM_002417 (MKI67, Antigen identified by monoclonal antibody Ki-67), gene accession number (GeneBank accession No. NM_002875 (RAD51, RAD51 homolog (RecA homolog, E.  coli) (S.  cerevisiae)), gene accession number (GeneBank accession No. NM_003884 (PCAF, P300 / CBP-associated factor), gene accession number (GeneBank accession No. NM_004526 (MCM2, MCM2 minichromosome maintenance deficient 2, mitotin (S.  cerevisiae)), gene accession number (GeneBank accession No. ) NM_004847 (AIF1, Allograft inflammatory factor 1), gene accession number (GeneBank accession No. NM_005915 (MCM6, MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S.  pombe) (S.  cerevisiae)), gene accession number (GeneBank accession No. ) NM_012090 (MACF1, Microtubule-actin crosslinking factor 1), Gene Registration Number (GeneBank accession No. NM_012415 (RAD54B, RAD54 homolog B (S.  cerevisiae)), gene accession number (GeneBank accession No. ) NM_014264 (PLK4, Polo-like kinase 4 (Drosophila)), gene accession number (GeneBank accession No. ) NM_015714 (G0S2, G0 / G1switch 2), gene accession number (GeneBank accession No. NM_024680 (FLJ23311, E2F transcription factor 8), gene accession number (GeneBank accession No. XM_034274 (MYBL1, V-myb myeloblastosis viral oncogene homolog (avian) -like 1), gene accession number (GeneBank accession No. ) AK001720 (FLJ10858, Nei endonuclease VIII-like 3 (E.  coli)), and GeneBank accession No. ) AY032677 (POLQ, Polymerase (DNA directed), theta), Gene Accession No. ) BC034480 (BLM, Bloom syndrome), Gene accession number (GeneBank accession No. BC073161 (RAD51C, RAD51 homolog C (S.  cerevisiae)), gene accession number (GeneBank accession No. CR600021 (HMGB2, High-mobility group box 2), gene accession number (GeneBank accession No. CR625391 (RAD51AP1, RAD51 associated protein 1), gene accession number (GeneBank accession No. CR936783 (FLJ40869, Hypothetical protein LOC284952), gene accession number (GeneBank accession No. ) DQ140356 (KIAA1596, Fanconi anemia, complementation group M), gene accession number (GeneBank accession No. ) NM_001067 (TOP2A, Topoisomerase (DNA) II alpha 170kDa), gene accession number (GeneBank accession No. ) NM_001618 (PARP1, Poly (ADP-ribose) polymerase family, member 1), gene accession number (GeneBank accession No. ) NM_003362 (UNG, Uracil-DNA glycosylase), gene accession number (GeneBank accession No. ) NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), Gene accession number (GeneBank accession No. ) NM_130398 (EXO1, Exonuclease 1), gene accession number (GeneBank accession No. ) AB020807 (TLR6, Toll-like receptor 6), gene accession number (GeneBank accession No. ) AB032980 (DCDC2, Doublecortin domain containing 2), gene accession number (GeneBank accession No. ) AB209866 (TFPI, Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)), gene accession number (GeneBank accession No. ) AK057015 (HSPA4, Heat shock 70kDa protein 4), Gene accession number (GeneBank accession No. ) AK095515 (IFIT1, Interferon-induced protein with tetratricopeptide repeats 1), gene accession number (GeneBank accession No. ) AK122686 (IF, I factor (complement), gene accession number (GeneBank accession No. ) AK123010 (RRM2, Ribonucleotide reductase M2 polypeptide), gene accession number (GeneBank accession No. ) BC035582 (TRIM22, Tripartite motif-containing 22), gene accession number (GeneBank accession No. ) BX537894 (LOC493869, Similar to RIKEN cDNA 2310016C16), gene accession number (GeneBank accession No. ) M14338 (PROS1, Protein S (alpha)), gene accession number (GeneBank accession No. ) NM_000821 (GGCX, Gamma-glutamyl carboxylase), gene accession number (GeneBank accession No. ) NM_000963 (PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G / H synthase and cyclooxygenase)), Gene Accession No. NM_001001547 (CD36, CD36 antigen (collagen type I receptor, thrombospondin receptor)), gene accession number (GeneBank accession No. NM_001512 (GSTA4, Glutathione S-transferase A4), gene accession number (GeneBank accession No. NM_001629 (ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), gene accession number (GeneBank accession No. ) NM_001752 (CAT, Catalase), gene accession number (GeneBank accession No. NM_001837 (CCR3, Chemokine (C-C motif) receptor 3), gene accession number (GeneBank accession No. ) NM_001979 (EPHX2, Epoxide hydrolase 2, cytoplasmic), gene registration number (GeneBank accession No. ) NM_001994 (F13B, Coagulation factor XIII, B polypeptide), gene accession number (GeneBank accession No. ) NM_002182 (IL1RAP, Interleukin 1 receptor accessory protein), gene accession number (GeneBank accession No. ) NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), Gene accession number (GeneBank accession No. NM_173216 (SIAT1, ST6 beta-galactosamide alpha-2,6-sylyltranferase 1), gene accession number (GeneBank accession No. NM_202002 (FOXM1, Forkhead box M1), gene accession number (GeneBank accession No. ) AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase), Gene accession number (GeneBank accession No. ) BC027881 (AFP, Alpha-fetoprotein), gene accession number (GeneBank accession No. ) NM_015915 (SPG3A, Spastic paraplegia 3A (autosomal dominant)), gene accession number (GeneBank accession No. ) NM_000671 (ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), gene registration number (GeneBank accession No. ) J05428 (UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), gene accession number (GeneBank accession No. ) NM_000672 (ADH6, Alcohol dehydrogenase 6 (class V)), gene accession number (GeneBank accession No. ) M15943 (ADH4, Alcohol dehydrogenase 4 (class II), pi polypeptide), gene accession number (GeneBank accession No. ) AK223395 (FBP1, Fructose-1,6-bisphosphatase 1), gene accession number (GeneBank accession No. NM_000151 (G6PC, Glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)), gene accession number (GeneBank accession No. XM_113962 (KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), gene accession number (GeneBank accession No. ) AB020644 (ACSL6, Acyl-CoA synthetase long-chain family member 6), gene accession number (GeneBank accession No. ) AB209907 (PLD1, Phospholipase D1, phophatidylcholine-specific), gene accession number (GeneBank accession No. ) AF285167 (ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1), gene accession number (GeneBank accession No. ) AF297872 (TRERF1, Transcriptional regulating factor 1), gene registration number (GeneBank accession No. ) AF303134 (ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), gene accession number (GeneBank accession No. ) AF339053 (PLA2G12B, Phospholipase A2, group XIIB), gene accession number (GeneBank accession No. ) AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), gene accession number (GeneBank accession No. ) AK124635 (PCSK9, Proprotein convertase subtilisin / kexin type 9), gene registration number (GeneBank accession No. ) AK127346 (SIAT9, ST3 beta-galactoside alpha-2,3- sialyltransferase 5), gene accession number (GeneBank accession No. ) AL359559 (AGPS, Alkylglycerone phosphate synthase), gene accession number (GeneBank accession No. ) AY691170 (PLCL3, Phospholipase C-like 3), gene accession number (GeneBank accession No. ) BG567934 (APOM, Apolipoprotein M), gene accession number (GeneBank accession No. ) BX538214 (C6orf167, Chromosome 6 open reading frame 167), gene accession number (GeneBank accession No. ) BX640945 (FADS2, Fatty acid desaturase 2), gene accession number (GeneBank accession No. ) BX648473 (PIGK, Phosphatidylinositol glycan, class K), gene accession number (GeneBank accession No. ) BX648557 (HSD17B2, Hydroxysteroid (17-beta) dehydrogenase 2), Gene accession number (GeneBank accession No. ) CR749601 (ETNK1, Death-associated protein kinase 3), gene accession number (GeneBank accession No. ) NM_000859 (HMGCR, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase), gene accession number (GeneBank accession No. ) NM_001443 (FABP1, Fatty acid binding protein 1, liver), gene accession number (GeneBank accession No. ) NM_002130 (HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)), gene accession number (GeneBank accession No. ) NM_003725 (RODH, Hydroxysteroid (17-beta) dehydrogenase 6), Gene accession number (GeneBank accession No. NM_004845 (PCYT1B, Phosphate cytidylyltransferase 1, choline, beta), Gene accession number (GeneBank accession No. ) NM_014762 (DHCR24, 24-dehydrocholesterol reductase), gene accession number (GeneBank accession No. ) NM_020139 (DHRS6, Dehydrogenase / reductase (SDR family) member 6), gene registration number (GeneBank accession No. NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), gene accession number (GeneBank accession No. NM_032523 (OSBPL6, Oxysterol binding protein-like 6), gene accession number (GeneBank accession No. ) NM_033505 (SELI, Selenoprotein I), gene accession number (GeneBank accession No. ) Z28339 (AKR1D1, Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)), GeneBank accession No. ) AK024899 (ENPP3, Ectonucleotide pyrophosphatase / phosphodiesterase 3), gene accession number (GeneBank accession No. ) AK025546 (PTPN4, Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)), Gene accession number (GeneBank accession No. ) AK124910 (ENPP2, Ectonucleotide pyrophosphatase / phosphodiesterase 2 (autotaxin)), gene accession number (GeneBank accession No. ) BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538), gene registration number (GeneBank accession No. ) BC050565 (PASK, PAS domain containing serine / threonine kinase), gene accession number (GeneBank accession No. ) L13436 (NPR2, Natriuretic peptide receptor B / guanylate cyclase B (atrionatriuretic peptide receptor B)), gene accession number (GeneBank accession No. ) NM_001005862 (ERBB2, V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro / glioblastoma derived oncogene homolog (avian)), gene accession number (GeneBank accession No. NM_005012 (ROR1, Receptor tyrosine kinase-like orphan receptor 1), gene accession number (GeneBank accession No. NM_006035 (CDC42BPB, CDC42 binding protein kinase beta (DMPK-like)), gene accession number (GeneBank accession No. NM_014791 (MELK, Maternal embryonic leucine zipper kinase), gene accession number (GeneBank accession No. NM_023028 (FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), gene registration number (GeneBank accession No. ) NM_080836 (STK35, Serine / threonine kinase 35), gene accession number (GeneBank accession No. ) AF419331 (FUSIP1, FUS interacting protein (serine / arginine-rich) 1), gene accession number (GeneBank accession No. ) AK091927 (SFRS3, Splicing factor, arginine / serine-rich 3), gene accession number (GeneBank accession No. ) BC010266 (HNRNPA1, Heterogeneous nuclear ribonucleoprotein A1), gene accession number (GeneBank accession No. ) BC012360 (CTAGE5, CTAGE family, member 5), gene accession number (GeneBank accession No. ) BC036046 (PLRG1, Pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)), gene accession number (GeneBank accession No. BC065384 (PCF11, PCF11, cleavage and polyadenylation factor subunit, homolog (S.  cerevisiae)), gene accession number (GeneBank accession No. ) BX537360 (CPSF5, Nudix (nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No. ) BX537494 (HNRPA2B1, Heterogeneous nuclear ribonucleoprotein A2 / B1), gene accession number (GeneBank accession No. ) BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), gene registration number (GeneBank accession No. ) CA455267 (PPIH, Peptidyl prolyl isomerase H (cyclophilin H)), gene accession number (GeneBank accession No. ) CR596214 (HNRPA0, Heterogeneous nuclear ribonucleoprotein A0), gene accession number (GeneBank accession No. NM_001326 (CSTF3, Hypothetical protein LOC283267), gene accession number (GeneBank accession No. ) NM_004640 (BAT1, HLA-B associated transcript 1), gene accession number (GeneBank accession No. NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), gene accession number (GeneBank accession No. ) NM_006924 (SFRS1, Splicing factor, arginine / serine-rich 1 (splicing factor 2, alternate splicing factor)), gene accession number (GeneBank accession No. ) NM_012426 (SF3B3, Splicing factor 3b, subunit 3, 130 kDa), Gene accession number (GeneBank accession No. NM_018048 (FLJ10292, Mago-nashi homolog), gene accession number (GeneBank accession No. NM_030919 (C20orf129, Chromosome 20 open reading frame 129), gene accession number (GeneBank accession No. ) NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37 kDa)), gene registration number (GeneBank accession No. ) NM_138933 (ACF, Apobec-1 complementation factor), gene accession number (GeneBank accession No. ) AB193259 (ACE2, Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2), gene accession number (GeneBank accession No. ) BX648769 (EWSR1, Ewing sarcoma breakpoint region 1), gene accession number (GeneBank accession No. ) AB023154 (DTX4, Deltex 4 homolog (Drosophila)), gene accession number (GeneBank accession No. ) AL543755 (VAV3, Vav 3 oncogene), gene accession number (GeneBank accession No. ) M75106 (CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), gene accession number (GeneBank accession No. NM_021045 (ZNF248, Zinc finger protein 248), gene accession number (GeneBank accession No. ) AB209194 (B4GALT6, UDP-Gal: betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6), gene accession number (GeneBank accession No. ) AF279145 (ANTXR1, Anthrax toxin receptor 1), gene accession number (GeneBank accession No. ) NM_025074 (FRAS1, Fraser syndrome 1), gene accession number (GeneBank accession No. ) AK025790 (KIF20A, Kinesin family member 20A), gene accession number (GeneBank accession No. ) NM_006152 (LRMP, Lymphoid-restricted membrane protein), gene accession number (GeneBank accession No. ) NM_000340 (SLC2A2, Solute carrier family 2 (facilitated glucose transporter), member 2), gene accession number (GeneBank accession No. ) AF071592 (KIF4A, Kinesin family member 4A), gene accession number (GeneBank accession No. NM_013277 (RACGAP1, Rac GTPase activating protein 1), gene accession number (GeneBank accession No. ) AY043484 (SCN1A, Sodium channel, voltage-gated, type I, alpha), Gene Registration Number (GeneBank accession No. ) AY791349 (KIF18A, Kinesin family member 18A), gene accession number (GeneBank accession No. ) NM_018018 (SLC38A4, Solute carrier family 38, member 4), gene accession number (GeneBank accession No. ) AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. ), Gene accession number (GeneBank accession No. NM_021069 (ARGBP2, Sorbin and SH3 domain containing 2), gene accession number (GeneBank accession No. NM_001005747 (CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), Gene accession number (GeneBank accession No. ) AJ496568 (SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), gene accession number (GeneBank accession No. ) NM_030641 (APOL6, Apolipoprotein L, 6), gene accession number (GeneBank accession No. NM_173512 (FLJ39822, Hypothetical protein FLJ39822), gene accession number (GeneBank accession No. ) NM_000037 (ANK1, Ankyrin 1, erythrocytic), gene accession number (GeneBank accession No. ) NM_001011554 (SLC13A3, Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3), gene accession number (GeneBank accession No. ) AB091343 (C10orf3, Centrosomal protein 55kDa), gene accession number (GeneBank accession No. ) AK000643 (ASB9, Ankyrin repeat and SOCS box-containing 9), gene accession number (GeneBank accession No. ) AK055221 (FBXO5, F-box protein 5), gene accession number (GeneBank accession No. ) AK075271 (SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2)), gene accession number (GeneBank accession No. ) AK122685 (GLUD1, Glutamate dehydrogenase 1), gene accession number (GeneBank accession No. ) AK127098 (FLJ10706, Chromosome 1 open reading frame 112), gene accession number (GeneBank accession No. ) AL133031 (MLR1, Transcription factor MLR1), gene accession number (GeneBank accession No. ) AY007723 (MAL2, Mal, T-cell differentiation protein 2), gene accession number (GeneBank accession No. BC022255 (Spc25, Spindle pole body component 25 homolog (S.  cerevisiae)), gene accession number (GeneBank accession No. ) BC041882 (ATF7IP2, Activating transcription factor 7 interacting protein 2), gene accession number (GeneBank accession No. ) BC052951 (LMNB1, Lamin B1), gene accession number (GeneBank accession No. ) BC098313 (FLJ20641, Hypothetical protein FLJ20641), gene accession number (GeneBank accession No. ) NM_001809 (CENPA, Centromere protein A, 17kDa), gene accession number (GeneBank accession No. NM_145061 (C13orf3, Chromosome 13 open reading frame 3), gene accession number (GeneBank accession No. XM_372695 (LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859), mRNA). The biomarker of claim 1, wherein the following genes are increased in expression by exposure to phenanthrene: Gene accession number (GeneBank accession No. ) NM_004420 (DUSP8, Dual specificity phosphatase 8), gene accession number (GeneBank accession No. ) L11329 (DUSP2, Dual specificity phosphatase 2), gene accession number (GeneBank accession No. ) BC094766 (PKN1, Protein kinase N1), gene accession number (GeneBank accession No. ) AY247738 (TRIB3, Tribbles homolog 3 (Drosophila)), gene registration number (GeneBank accession No. ) AK129595 (GADD45B, Growth arrest and DNA-damage-inducible, beta), Gene Accession No. ) AB208849 (SHC1, Src homology 2 domain containing (SHC) transforming protein 1), gene accession number (GeneBank accession No. ) X02812 (TGFB1, Transforming growth factor, beta 1 (Camurati-Engelmann disease)), Gene Accession No. ) NM_198951 (TGM2, Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)), gene registration number (GeneBank accession No. NM_147780 (CTSB, Cathepsin B), gene accession number (GeneBank accession No. NM_078467 (CDKN1A, Cyclin-dependent kinase inhibitor 1A (p21, Cip1)), gene accession number (GeneBank accession No. NM_033027 (AXUD1, AXIN1 up-regulated 1), gene accession number (GeneBank accession No. NM_032797 (AMID, Apoptosis-inducing factor (AIF) -like mitochondrion-associated inducer of death), GeneBank accession No. ) NM_021960 (MCL1, Myeloid cell leukemia sequence 1 (BCL2-related)), gene registration number (GeneBank accession No. ) NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), gene accession number (GeneBank accession No. ) NM_016222 (DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41), gene accession number (GeneBank accession No. ) NM_013246 (CLC, Cardiotrophin-like cytokine factor 1), gene accession number (GeneBank accession No. ) NM_004401 (DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide), gene registration number (GeneBank accession No. ) NM_004281 (BAG3, BCL2-associated athanogene 3), gene accession number (GeneBank accession No. ) NM_003897 (IER3, Immediate early response 3), Gene accession number (GeneBank accession No. ) NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), gene accession number (GeneBank accession No. ) NM_003639 (IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), GeneBank accession No. ) NM_003311 (PHLDA2, Pleckstrin homology-like domain, family A, member 2), gene accession number (GeneBank accession No. ) NM_002737 (PRKCA, Protein Kinase C, alpha), Gene Accession Number (GeneBank accession No. NM_002648 (PIM1, Pim-1 oncogene), gene accession number (GeneBank accession No. NM_002507 (NGFR, Nerve growth factor receptor (TNFR superfamily, member 16)), gene accession number (GeneBank accession No. ) NM_002305 (LGALS1, Lectin, galactoside-binding, soluble, 1 (galectin 1)), gene accession number (GeneBank accession No. ) NM_001013398 (IGFBP3, Insulin-like growth factor binding protein 3), gene registration number (GeneBank accession No. ) BX640923 (MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)), gene accession number (GeneBank accession No. ) BX537586 (STK17A, Serine / threonine kinase 17a (apoptosis-inducing)), gene accession number (GeneBank accession No. ) BG284742 (P8, P8 protein (candidate of metastasis 1)), gene accession number (GeneBank accession No. ) BE903247 (PDCD6IP, Programmed cell death 6 interacting protein), gene accession number (GeneBank accession No. ) BC027949 (P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), gene accession number (GeneBank accession No. ) BC006365 (PSEN2, Presenilin 2 (Alzheimer disease 4)), gene accession number (GeneBank accession No. ) AY869712 (PPP1R13L, Protein phosphatase 1, regulatory (inhibitor) subunit 13 like), Gene Accession No. ) AY028896 (CARD10, Caspase recruitment domain family, member 10), gene accession number (GeneBank accession No. ) AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), gene accession number (GeneBank accession No. ) AK092872 (ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)), gene registration number (GeneBank accession No. ) AK092808 (RRAGC, Ras-related GTP binding C), gene accession number (GeneBank accession No. ) AJ001898 (GDNF, Glial cell derived neurotrophic factor), gene accession number (GeneBank accession No. ) AF220656 (PHLDA1, Pleckstrin homology-like domain, family A, member 1), gene accession number (GeneBank accession No. AF055634 (UNC5C, Unc-5 homolog C (C.  elegans), GeneBank accession No. ) AB209485 (Vescular endothelial growth factor), gene accession number (GeneBank accession No. ) AB096256 (UNC5B, Unc-5 homolog B (C.  elegans), GeneBank accession No. ) AB007960 (SH3GLB1, SH3-domain GRB2-like endophilin B1), gene accession number (GeneBank accession No. ) X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), Gene accession number (GeneBank accession No. ) S62138 (DDIT3, DNA-damage-inducible transcript 3), gene accession number (GeneBank accession No. NM_078487 (CDKN2B, Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)), gene accession number (GeneBank accession No. ) NM_012127 (CIZ1, CDKN1A interacting zinc finger protein 1), gene accession number (GeneBank accession No. ) NM_005883 (APC2, Adenomatosis polyposis coli 2), gene accession number (GeneBank accession No. ) NM_004196 (CDKL1, Cyclin-dependent kinase-like 1 (CDC2-related kinase)), gene accession number (GeneBank accession No. ) NM_003236 (TGFA, Transforming growth factor, alpha), gene registration number (GeneBank accession No. ) NM_001261 (CDK9, Cyclin-dependent kinase 9 (CDC2-related kinase)), gene accession number (GeneBank accession No. ) NM_001007271 (DUSP13, Dual specificity phosphatase 13), gene accession number (GeneBank accession No. CR749511 (PARC, P53-associated parkin-like cytoplasmic protein), gene accession number (GeneBank accession No. CR623038 (ID2, Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein), gene accession number (GeneBank accession No. CR618371 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)), GeneBank accession No. ) BF965144 (IFITM1, Interferon induced transmembrane protein 1 (9-27)), gene accession number (GeneBank accession No. ) AK127679 (DUSP1, Dual specificity phosphatase 1), gene accession number (GeneBank accession No. ) AK096276 (CCND3, Cyclin D3), gene accession number (GeneBank accession No. ) AB209586 (MAPK13, Mitogen-activated protein kinase 13), gene accession number (GeneBank accession No. ) AB209465 (PCTK1, PCTAIRE protein kinase 1), gene accession number (GeneBank accession No. ) Z19588 (SKIL, SKI-like), gene accession number (GeneBank accession No. NM_020429 (SMURF1, SMAD specific E3 ubiquitin protein ligase 1), gene accession number (GeneBank accession No. ) NM_014767 (SPOCK2, Sparc / osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2), Gene Accession No. ) NM_005979 (S100A13, S100 calcium binding protein A13), gene registration number (GeneBank accession No. NM_005187 (CBFA2T3, Core-binding factor, runt domain, alpha subunit 2; translocated to, 3), gene accession number (GeneBank accession No. ) NM_004364 (CEBPA, CCAAT / enhancer binding protein (C / EBP), alpha), gene registration number (GeneBank accession No. ) NM_001769 (CD9, CD9 antigen (p24)), gene accession number (GeneBank accession No. ) NM_001718 (BMP6, Bone morphogenetic protein 6), gene accession number (GeneBank accession No. ) NM_000641 (IL11, Interleukin 11), gene accession number (GeneBank accession No. ) BX647459 (SERPINE2, Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2), gene registration number (GeneBank accession No. ) BQ066037 (RPS19, Ribosomal protein S19), gene accession number (GeneBank accession No. ) BE791300 (EDF1, Endothelial differentiation-related factor 1), Gene accession number (GeneBank accession No. ) BC038504 (SNF1LK, SNF1-like kinase), gene accession number (GeneBank accession No. ) AL832287 (ZAP70, Zeta-chain (TCR) associated protein kinase 70kDa), gene accession number (GeneBank accession No. ) AK125742 (PCGF1, Polycomb group ring finger 1), gene accession number (GeneBank accession No. ) AK124709 (NDRG1, N-myc downstream regulated gene 1), gene accession number (GeneBank accession No. ) AB011157 (PTDSR, Phosphatidylserine receptor), Gene Accession No. NM_013255 (MKLN1, Muskelin 1, intracellular mediator containing kelch motifs), gene accession number (GeneBank accession No. ) NM_006572 (GNA13, Guanine nucleotide binding protein (G protein), alpha 13), gene registration number (GeneBank accession No. NM_002211 (ITGB1, Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)), gene accession number (GeneBank accession No. ) CR601067 (PLAUR, Plasminogen activator, urokinase receptor), gene accession number (GeneBank accession No. ) BC050456 (THBS4, Thrombospondin 4), gene accession number (GeneBank accession No. ) AK027389 (CXCL16, Chemokine (C-X-C motif) ligand 16), gene accession number (GeneBank accession No. ) AJ132099 (VNN1, Vanin 1), gene accession number (GeneBank accession No. ) XM_371354 (FLJ10157, Hypothetical protein FLJ10157), gene accession number (GeneBank accession No. ) XM_208313 (TPM3, Similar to tropomyosin 4), gene accession number (GeneBank accession No. XM_208270 (ACR, Acrosin-like protease), gene accession number (GeneBank accession No. ) NM_203353 (PDLIM7, PDZ and LIM domain 7 (enigma)), gene accession number (GeneBank accession No. ) NM_201382 (PLEC1, Plectin 1, intermediate filament binding protein 500kDa), gene registration number (GeneBank accession No. ) NM_182961 (SYNE1, Spectrin repeat containing, nuclear envelope 1), gene accession number (GeneBank accession No. ) NM_181826 (NF2, Neurofibromin 2 (bilateral acoustic neuroma)), gene accession number (GeneBank accession No. NM_172069 (PLEKHH2, Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2), gene accession number (GeneBank accession No. ) NM_022648 (TNS, Tensin 1), gene accession number (GeneBank accession No. NM_017556 (FBLP-1, Filamin binding LIM protein 1), gene accession number (GeneBank accession No. NM_016081 (KIAA0992, Palladin, cytoskeletal associated protein), gene accession number (GeneBank accession No. ) NM_006617 (NES, Nestin), gene accession number (GeneBank accession No. ) NM_006262 (PRPH, Peripherin), gene accession number (GeneBank accession No. NM_005100 (AKAP12, A kinase (PRKA) anchor protein (gravin) 12), gene accession number (GeneBank accession No. NM_004368 (CNN2, Calponin 2), gene accession number (GeneBank accession No. ) NM_003388 (CYLN2, Cytoplasmic linker 2), gene accession number (GeneBank accession No. ) NM_003370 (VASP, Vasodilator-stimulated phosphoprotein), gene accession number (GeneBank accession No. ) NM_003128 (SPTBN1, Spectrin, beta, non-erythrocytic 1), gene accession number (GeneBank accession No. ) NM_002705 (PPL, Periplakin), gene accession number (GeneBank accession No. ) NM_002475 (MLC1SA, Myosin light chain 1 slow a), Gene accession number (GeneBank accession No. ) NM_002018 (FLII, Flightless I homolog (Drosophila)), Gene Accession Number (GeneBank accession No. ) NM_001465 (FYB, FYN binding protein (FYB- 120/130)), gene registration number (GeneBank accession No. NM_001069 (TUBB2, Tubulin, beta 2A), gene accession number (GeneBank accession No. ) CR625172 (MGC8685, Tubulin, beta 2B), gene accession number (GeneBank accession No. CR616919 (KRT18, Keratin 18), gene accession number (GeneBank accession No. ) CR606241 (ACTG1, Actin, gamma 1), gene accession number (GeneBank accession No. ) CB240572 (MYH11, Myosin, heavy polypeptide 11, smooth muscle), gene accession number (GeneBank accession No. ) BX648253 (PTPN3, Protein tyrosine phosphatase, non-receptor type 3), Gene accession number (GeneBank accession No. ) BX648190 (WDR1, WD repeat domain 1), Gene accession number (GeneBank accession No. ) BX641076 (ACTN1, Actinin, alpha 1), gene accession number (GeneBank accession No. ) BX537978 (EPB41L1, Erythrocyte membrane protein band 4. 1-like 1), gene accession number (GeneBank accession No. ) BG121847 (NUDC, Nuclear distribution gene C homolog (A.  nidulans)), and GeneBank accession No. ) BC068013 (MYO1C, Myosin IC), gene accession number (GeneBank accession No. ) BC065499 (MAST2, Microtubule associated serine / threonine kinase 2), gene accession number (GeneBank accession No. ) BC051890 (TUBG2, Tubulin, gamma 2), gene accession number (GeneBank accession No. ) BC041874 (MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta), gene accession number (GeneBank accession No. ) BC012597 (ACTA1, Actin, alpha 1, skeletal muscle), gene accession number (GeneBank accession No. ) AY484427 (KIF17, Kinesin family member 17), gene accession number (GeneBank accession No. ) AK130546 (STOML2, Stomatin (EPB72) -like 2), Gene accession number (GeneBank accession No. ) AK124711 (CORO2B, Coronin, actin binding protein, 2B), gene accession number (GeneBank accession No. ) AK123974 (MYL5, Myosin, light polypeptide 5, regulatory), gene accession number (GeneBank accession No. ) AK092792 (LOC389833, Similar to hypothetical protein MGC27019), gene accession number (GeneBank accession No. ) AK026518 (MYOHD1, Myosin head domain containing 1), gene accession number (GeneBank accession No. ) AK024500 (NICAL, Microtubule associated monoxygenase, calponin and LIM domain containing 1), gene accession number (GeneBank accession No. ) AF085886 (FLJ46675, Ribosomal protein L29 pseudogene 2), gene accession number (GeneBank accession No. ) AB209997 (MYO9B, Myosin IXB), gene accession number (GeneBank accession No. Y12692 (WNT11, Wingless-type MMTV integration site family, member 11), gene accession number (GeneBank accession No. ) Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), gene accession number (GeneBank accession No. X17033 (ITGA2, Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)), gene accession number (GeneBank accession No. ) U41763 (CLTCL1, Clathrin, heavy polypeptide-like 1), gene accession number (GeneBank accession No. NM_153609 (TMPRSS6, Transmembrane protease, serine 6), gene accession number (GeneBank accession No. ) NM_031483 (ITCH, Itchy homolog E3 ubiquitin protein ligase (mouse)), gene accession number (GeneBank accession No. ) NM_024342 (GRLF1, Glucocorticoid receptor DNA binding factor 1), gene accession number (GeneBank accession No. NM_017555 (EGLN2, Egl nine homolog 2 (C.  elegans), GeneBank accession No. NM_016569 (TBX3, T-box 3 (ulnar mammary syndrome)), gene accession number (GeneBank accession No. NM_004148 (NINJ1, Ninjurin 1), gene accession number (GeneBank accession No. ) NM_003377 (VEGFB, Vascular endothelial growth factor B), gene accession number (GeneBank accession No. ) NM_001983 (ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)), GeneBank accession No. ) NM_001552 (IGFBP4, Insulin-like growth factor binding protein 4), gene registration number (GeneBank accession No. ) NM_001430 (EPAS1, Endothelial PAS domain protein 1), Gene accession number (GeneBank accession No. NM_001300 (KLF6, Kruppel-like factor 6), gene accession number (GeneBank accession No. ) NM_001012661 (SLC3A2, Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), gene accession number (GeneBank accession No. NM_000596 (IGFBP1, Insulin-like growth factor binding protein 1), gene registration number (GeneBank accession No. ) NM_000474 (TWIST1, Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)), Gene Accession No. ) BX649103 (ChGn, Chondroitin beta1,4 N-acetylgalactosaminyltransferase), Gene Accession No. ) BM913048 (TIMP1, TIMP metallopeptidase inhibitor 1), gene accession number (GeneBank accession No. ) BM904612 (S100A6, S100 calcium binding protein A6 (calcyclin)), gene accession number (GeneBank accession No. ) BM556279 (EMP3, Epithelial membrane protein 3), gene accession number (GeneBank accession No. ) BC015041 (VAT1, Family with sequence similarity 82, member C), gene accession number (GeneBank accession No. ) AY258066 (OKL38, Pregnancy-induced growth inhibitor), gene accession number (GeneBank accession No. ) AK126729 (NDRG4, NDRG family member 4), gene accession number (GeneBank accession No. ) AK090459 (NFE2L1, Nuclear factor (erythroid-derived 2) -like 1), gene accession number (GeneBank accession No. ) AK074163 (ROBO4, Roundabout homolog 4, magic roundabout (Drosophila)), Gene accession number (GeneBank accession No. ) AK024680 (FLJ21027 fis, CDNA: FLJ21027 fis, clone CAE07110), gene accession number (GeneBank accession No. ) AF176422 (HEY1, Hairy / enhancer-of-split related with YRPW motif 1), gene accession number (GeneBank accession No. ) AF003837 (JAG1, Jagged 1 (Alagille syndrome)), gene accession number (GeneBank accession No. ) AB209322 (SEMA3B, Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B), GeneBank accession No. ) AB011150 (NRXN1, Neurexin 1), gene accession number (GeneBank accession No. ) NM_201589 (MAFA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)), gene accession number (GeneBank accession No. NM_052999 (CKLFSF1, CKLF-like MARVEL transmembrane domain containing 1), gene accession number (GeneBank accession No. NM_006644 (HSPH1, Heat shock 105kDa / 110kDa protein 1), gene registration number (GeneBank accession No. NM_005438 (FOSL1, FOS-like antigen 1), gene accession number (GeneBank accession No. ) NM_004996 (ABCC1, ATP-binding cassette, sub-family C (CFTR / MRP), member 1), gene accession number (GeneBank accession No. ) NM_002658 (PLAU, Plasminogen activator, urokinase), gene accession number (GeneBank accession No. ) NM_001353 (AKR1C1, Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha) -hydroxysteroid dehydrogenase)), gene accession number (GeneBank accession No. ) H18681 (C20orf139, Sulfiredoxin 1 homolog (S.  cerevisiae)), gene accession number (GeneBank accession No. ) DR004094 (HAMP, Hepcidin antimicrobial peptide), gene accession number (GeneBank accession No. ) BC082272 (KCNMB3, Potassium large conductance calcium-activated channel, subfamily M beta member 3), Gene Accession No. ) BC040494 (DNAJB2, DnaJ (Hsp40) homolog, subfamily B, member 2), gene accession number (GeneBank accession No. ) BC018064 (ATF6, Activating transcription factor 6), gene accession number (GeneBank accession No. ) BC006523 (SGK2, Serum / glucocorticoid regulated kinase 2), gene registration number (GeneBank accession No. ) AK090482 (CXCL12, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)), gene accession number (GeneBank accession No. ) AF219946 (TULP4, Tubby like protein 4), gene accession number (GeneBank accession No. ) AB209112 (SLC2A8, Solute carrier family 2, (facilitated glucose transporter) member 8), gene accession number (GeneBank accession No. ) NM_005242 (F2RL1, Coagulation factor II (thrombin) receptor-like 1), gene accession number (GeneBank accession No. ) NM_001002029 (C4A, Complement component 4B, telomeric), Gene accession number (GeneBank accession No. ) NM_000539 (RHO, Rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)), gene accession number (GeneBank accession No. ) BX649164 (PAI, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), gene registration number (GeneBank accession No. ) BM918324 (LY96, Lymphocyte antigen 96), gene accession number (GeneBank accession No. ) AB209647 (NCF2, Neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2)), gene accession number (GeneBank accession No. ) NM_152221 (CSNK1E, Casein kinase 1, epsilon), Gene accession number (GeneBank accession No. ) NM_017999 (RNF31, Ring finger protein 31), gene accession number (GeneBank accession No. ) NM_016819 (OGG1, 8-oxoguanine DNA glycosylase), gene accession number (GeneBank accession No. ) NM_016816 (OAS1, 2 ', 5'-oligoadenylate synthetase 1, 40 / 46kDa), Gene Accession No. NM_012235 (SCAP, SREBP cleavage-activating protein), gene accession number (GeneBank accession No. ) NM_006384 (CIB1, Calcium and integrin binding 1 (calmyrin)), gene accession number (GeneBank accession No. ) NM_001779 (CD58, CD58 antigen, (lymphocyte function-associated antigen 3)), gene accession number (GeneBank accession No. ) CB055213 (ICOSLG, Inducible T-cell co-stimulator ligand), Gene accession number (GeneBank accession No. ) BX641029 (MASP1, Mannan-binding lectin serine peptidase 1 (C4 / C2 activating component of Ra-reactive factor)), GeneBank accession No. ) BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), Gene Accession No. ) BC039299 (STIP1, Stress-induced-phosphoprotein 1 (Hsp70 / Hsp90-organizing protein)), gene accession number (GeneBank accession No. ) AY055760 (DAF, Decay accelerating factor for complement (CD55, Cromer blood group system)), gene accession number (GeneBank accession No. ) AK130188 (FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog), Gene Accession No. ) AK095326 (MUS81, MUS81 endonuclease homolog (yeast)), gene accession number (GeneBank accession No. NM_017670 (OTUB1, OTU domain, ubiquitin aldehyde binding 1), gene registration number (GeneBank accession No. ) NM_003004 (SECTM1, Secreted and transmembrane 1), gene accession number (GeneBank accession No. ) NM_002309 (LIF, Hypothetical protein MGC20647), gene accession number (GeneBank accession No. ) NM_001421 (ELF4, E74-like factor 4 (ets domain transcription factor)), gene accession number (GeneBank accession No. ) NM_000418 (IL4R, Interleukin 4 receptor), gene accession number (GeneBank accession No. ) BI909222 (FCER1G, Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide), gene accession number (GeneBank accession No. ) BF569086 (NK4, Interleukin 32), gene accession number (GeneBank accession No. ) BC014470 (AZGP1, Alpha-2-glycoprotein 1, zinc), gene accession number (GeneBank accession No. ) BC020744 (AKR1C4, Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol), dehydrogenase 4), gene accession number (GeneBank accession No. ) BQ939577 (AKR1C3, Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)), gene accession number (GeneBank accession No. ) NM_000499 (CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), gene accession number (GeneBank accession No. ) NM_030622 (CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), gene accession number (GeneBank accession No. ) NM_184041 (ALDOA, Aldolase A, fructose-bisphosphate), gene accession number (GeneBank accession No. ) NM_024307 (MGC4171, Hypothetical protein LOC283901), gene accession number (GeneBank accession No. ) NM_005336 (HDLBP, High density lipoprotein binding protein (vigilin)), gene registration number (GeneBank accession No. NM_002627 (PFKP, Phosphofructokinase, platelet), Gene accession number (GeneBank accession No. ) BX648281 (LDLR, low density lipoprotein receptor (familial hypercholesterolemia)), gene accession number (GeneBank accession No. ) BC069201 (FLJ22761, Hexokinase domain containing 1), gene accession number (GeneBank accession No. ) BC030207 (NR0B2, Nuclear receptor subfamily 0, group B, member 2), gene accession number (GeneBank accession No. ) AL833069 (KIAA1434, Hypothetical protein KIAA1434), gene accession number (GeneBank accession No. ) AK124656 (ENO2, Enolase 2 (gamma, neuronal)), gene accession number (GeneBank accession No. ) AK094474 (RHOC, Ras homolog gene family, member C), gene accession number (GeneBank accession No. ) AK093461 (ISYNA1, Myo-inositol 1-phosphate synthase A1), gene accession number (GeneBank accession No. ) AB053232 (GAL3ST3, Galactose-3-O-sulfotransferase 3), gene accession number (GeneBank accession No. ) AB045292 (TMEM8, Transmembrane protein 8 (five membrane-spanning domains)), gene accession number (GeneBank accession No. ) NM_004753 (DHRS3, Dehydrogenase / reductase (SDR family) member 3), Gene accession number (GeneBank accession No. ) NM_002900 (RBP3, Retinol binding protein 3, interstitial), gene accession number (GeneBank accession No. ) NM_001995 (ACSL1, Acyl-CoA synthetase long-chain family member 1), gene accession number (GeneBank accession No. NM_000018 (ACADVL, Acyl-Coenzyme A dehydrogenase, very long chain), gene accession number (GeneBank accession No. ) BC094756 (CRA, Myotubularin related protein 11), gene accession number (GeneBank accession No. ) BC050553 (NTE, Neuropathy target esterase), gene accession number (GeneBank accession No. ) BC033110 (HSD17B1, Hydroxysteroid (17-beta) dehydrogenase 1), Gene accession number (GeneBank accession No. ) AY268890 (TPP1, Tripeptidyl peptidase I), gene accession number (GeneBank accession No. ) AK172798 (CPT1A, Carnitine palmitoyltransferase 1A (liver)), gene accession number (GeneBank accession No. ) AK096809 (CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), gene accession number (GeneBank accession No. ) AK000600 (SIAT7D, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) -N-acetylgalactosaminide alpha-2,6-sialyltransferase 4), Gene accession number ) AB002454 (CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), gene accession number (GeneBank accession No. ) Z29093 (DDR1, Discoidin domain receptor family, member 1), gene accession number (GeneBank accession No. ) Z25424 (MKNK2, MAP kinase interacting serine / threonine kinase 2), gene accession number (GeneBank accession No. ) XM_291277 (DKFZp761P0423, Hypothetical protein DKFZp761P0423), gene accession number (GeneBank accession No. XM_038150 (MAST3, Microtubule associated serine / threonine kinase 3), gene accession number (GeneBank accession No. ) U88357 (ERBB3, V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)), gene accession number (GeneBank accession No. ) NM_025195 (TRIB1, Tribbles homolog 1 (Drosophila)), gene accession number (GeneBank accession No. NM_020639 (RIPK4, Receptor-interacting serine-threonine kinase 4), gene accession number (GeneBank accession No. ) NM_014172 (PHPT1, Phosphohistidine phosphatase 1), Gene accession number (GeneBank accession No. ) NM_006254 (PRKCD, Protein kinase C, delta), Gene accession number (GeneBank accession No. ) NM_005415 (SLC20A1, Solute carrier family 20 (phosphate transporter), member 1), gene accession number (GeneBank accession No. ) NM_005026 (PIK3CD, Phosphoinositide-3-kinase, catalytic, delta polypeptide), Gene accession number (GeneBank accession No. ) NM_004431 (EPHA2, EPH receptor A2), gene accession number (GeneBank accession No. ) NM_004419 (DUSP5, Dual specificity phosphatase 5), gene accession number (GeneBank accession No. ) NM_004327 (BCR, Breakpoint cluster region), Gene accession number (GeneBank accession No. ) NM_004231 (ATP6V1F, ATPase, H + transporting, lysosomal 14kDa, V1 subunit F), gene registration number (GeneBank accession No. ) NM_004090 (DUSP3, Dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)), gene accession number (GeneBank accession No. ) NM_002843 (PTPRJ, Protein tyrosine phosphatase, receptor type, J), gene accession number (GeneBank accession No. NM_002496 (NDUFS8, NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase)), gene accession number (GeneBank accession No. NM_001001852 (PIM3, Pim-3 oncogene), gene accession number (GeneBank accession No. ) L76191 (IRAK1, Interleukin-1 receptor-associated kinase 1), gene accession number (GeneBank accession No. ) D15049 (PTPRH, Protein tyrosine phosphatase, receptor type, H), gene accession number (GeneBank accession No. ) BC065207 (ATP6V0D2, ATPase, H + transporting, lysosomal 38kDa, V0 subunit d isoform 2), gene accession number (GeneBank accession No. ) BC035578 (STK24, Serine / threonine kinase 24 (STE20 homolog, yeast)), gene accession number (GeneBank accession No. ) BC028724 (DUSP18, Dual specificity phosphatase 18), gene accession number (GeneBank accession No. AL117482 (ULK3, Unc-51-like kinase 3 (C.  elegans), GeneBank accession No. ) AK126879 (PCTK3, PCTAIRE protein kinase 3), gene accession number (GeneBank accession No. ) AB209416 (ILK, Integrin-linked kinase-2), gene accession number (GeneBank accession No. ) NM_000782 (CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1), gene accession number (GeneBank accession No. ) CR597101 (ZFP36, Zinc finger protein 36, C3H type, homolog (mouse)), Gene accession number (GeneBank accession No. ) CR936799 (FHL2, Four and a half LIM domains 2), gene accession number (GeneBank accession No. ) M24898 (NR1D1, Nuclear receptor subfamily 1, group D, member 1), gene accession number (GeneBank accession No. ) AF132818 (KLF5, Kruppel-like factor 5 (intestinal)), gene accession number (GeneBank accession No. ) AK055337 (ZNF213, Zinc finger protein 213), Gene accession number (GeneBank accession No. ) BC008834 (PHF1, PHD finger protein 1), gene accession number (GeneBank accession No. ) AK126918 (GLIS2, GLIS family zinc finger 2), Gene accession number (GeneBank accession No. ) BC042692 (CTL2, Solute carrier family 44, member 2), gene accession number (GeneBank accession No. ) NM_002224 (ITPR3, Inositol 1,4,5-triphosphate receptor, type 3), gene accession number (GeneBank accession No. ) AK095363 (AQP3, Aquaporin 3), gene accession number (GeneBank accession No. NM_174953 (ATP2A3, ATPase, Ca ++ transporting, ubiquitous), gene accession number (GeneBank accession No. ) BC042390 (VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B (yeast)), GeneBank Accession No. NM_016113 (TRPV2, Transient receptor potential cation channel, subfamily V, member 2), gene accession number (GeneBank accession No. ) BM926478 (RBP1, Retinol binding protein 1, cellular), gene accession number (GeneBank accession No. NM_000069 (CACNA1S, Calcium channel, voltage-dependent, L type, alpha 1S subunit), Gene Registration Number (GeneBank accession No. ) AK002107 (RAB3B, RAB3B, member RAS oncogene family), gene accession number (GeneBank accession No. ) NM_013321 (SNX8, Sorting nexin 8), Gene accession number (GeneBank accession No. ) AK125026 (SLC6A12, Solute carrier family 6 (neurotransmitter transporter, betaine / GABA), member 12), gene accession number (GeneBank accession No. ) NM_005843 (STAM2, Signal transducing adapter molecule (SH3 domain and ITAM motif) 2), gene accession number (GeneBank accession No. ) AK092512 (SLC16A5, Solute carrier family 16 (monocarboxylic acid transporters), member 5), gene accession number (GeneBank accession No. ) U49248 (ABCC2, ATP-binding cassette, sub-family C (CFTR / MRP), member 2), gene accession number (GeneBank accession No. ) AK172792 (SCNN1A, Sodium channel, nonvoltage-gated 1 alpha), gene accession number (GeneBank accession No. ) BC044656 (CASC3, Cancer susceptibility candidate 3), gene accession number (GeneBank accession No. NM_203403 (C9orf150, Chromosome 9 open reading frame 150), gene accession number (GeneBank accession No. NM_080388 (S100A16, S100 calcium binding protein A16), gene registration number (GeneBank accession No. NM_031286 (SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), gene accession number (GeneBank accession No. NM_022153 (PP2135, Chromosome 10 open reading frame 54), gene accession number (GeneBank accession No. ) NM_004864 (GDF15, Growth differentiation factor 15), Gene accession number (GeneBank accession No. ) NM_003330 (TXNRD1, Thioredoxin reductase 1), gene accession number (GeneBank accession No. ) NM_001013632 (LOC343521, Similar to hypothetical protein 4833401D15), gene accession number (GeneBank accession No. ) BX537968 (LOC51149, Hypothetical LOC51149), gene accession number (GeneBank accession No. BU945318 (MT2A, Hypothetical gene supported by X97260; BC070289), gene accession number (GeneBank accession No. ) BQ683841 (S100A11, S100 calcium binding protein A11 (calgizzarin)), gene accession number (GeneBank accession No. ) BQ276852 (TMSB10, Thymosin, beta 10), gene accession number (GeneBank accession No. ) AK126182 (KIAA1949, KIAA1949), gene accession number (GeneBank accession No. ) AK124751 (CAPN2, Calpain 2, (m / II) large subunit), gene accession number (GeneBank accession No. ) AK095079 (RGC32, Response gene to complement 32), gene accession number (GeneBank accession No. ) AB075871 (FLJ42654, Golgi transport 1 homolog A (S.  cerevisiae)). The biomarker of claim 1, wherein the following genes are decreased in expression by exposure to phenanthrene: GeneBank accession No.AK125150 (MAPK8, Mitogen-activated protein kinase 8), GeneBank accession No. NM_002758 (MAP2K6, Mitogen-activated protein kinase kinase 6), Gene accession number (GeneBank accession No. NM_004612 (TGFBR1, Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kDa)), gene accession number (GeneBank accession No.) NM_145686 (MAP4K4, Mitogen-activated protein kinase kinase kinase 4) , GeneBank accession No. XM_042066 (MAP3K1, Mitogen-activated protein kinase kinase kinase 1), GeneBank accession No. AB011123 (TNIK, TRAF2 and NCK interacting kinase), Gene accession number (GeneBank accession No.) AB209031 (C5, Complement component 5), GeneBank accession No. NM_022740 (HIPK2, Homeodomain interacting protein kinase 2), GeneBank accession No. NM_148957 (TNFRSF19, Tumor necrosis factor receptor superf amily, member 19), GeneBank accession No. AB208909 (ITGB2, Integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1); macrophage antigen 1 (mac-1) beta subunit)), GeneBank accession No. AB209211 (TIA1, TIA1 cytotoxic granule-associated RNA binding protein), GeneBank accession No. AB209613 (DNASE1L3, Deoxyribonuclease) I-like 3), GeneBank accession No. AK122825 (HMGB1, High-mobility group box 1), GeneBank accession No. AK127326 (PHF17, PHD finger protein 17), Gene accession number ( GeneBank accession No.) AK223503 (CASP1, Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)), GeneBank accession No. BC013326 (GAS2, Growth arrest-specific 2), gene registration number GeneBank accession No. BC047698 (IL7, Interleukin 7), GeneBank accession No. D79987 (ESPL1, Extra spindle poles like 1 (S. cerevisiae)), GeneBank accession No. NM_000893 ( KNG1, Kininogen 1), GeneBank accession No. NM_001012271 (BIRC5, Eff ector cell peptidase receptor 1), GeneBank accession No. NM_004938 (DAPK1, Death-associated protein kinase 1), GeneBank accession No. NM_005879 (TRIP, TRAF interacting protein), Gene accession number ( GeneBank accession No.) NM_014739 (BCLAF1, BCL2-associated transcription factor 1), GeneBank accession No. NM_018947 (CYCS, Cytochrome c, somatic), Gene accession number AB033337 (MPHOSPH1, M -phase phosphoprotein 1), GeneBank accession No. AB209179 (PLK1, Polo-like kinase 1 (Drosophila)), Gene accession number (GeneBank accession No.) AB209337 (CDC7, CDC7 cell division cycle 7 (S. cerevisiae)), GeneBank accession No. AF053305 (BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)), GeneBank accession No. AF053306 (BUB1B, BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast), GeneBank accession No. AF345347 (SPAG5, Sperm associated antigen 5), GeneBank accession No. AK092638 (CCNG2, Cyclin G2), GeneBank accession No. AK222819 (NUSAP1, Nucleolar and spindle associated protein 1), GeneBank accession No. AL833191 (SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1 (yeast)), GeneBank accession No. AY257469 ( CIT, Citron (rho-interacting, serine / threonine kinase 21), GeneBank accession No. AY367065 (ASPM, Asp (abnormal spindle) -like, microcephaly associated (Drosophila)), GeneBank accession No.) BC011000 (CDCA5, Cell division cycle asso ciated 5), GeneBank accession No. BC032677 (UBE2C, Ubiquitin-conjugating enzyme E2C), GeneBank accession No. BC043502 (NEK2, never in mitosis gene a) -related kinase 2 , GeneBank accession No. BU675073 (PTTG1, Pituitary tumor-transforming 1), GeneBank accession No. BX647885 (STMN1, Stathmin 1 / oncoprotein 18), GeneBank accession No. CR592757 (BRRN1, Barren homolog 1 (Drosophila)), GeneBank accession No. CR597075 (MAPRE2, Microtubule-associated protein, RP / EB family, member 2), GeneBank accession No. CR604810 ( CCNA2, Cyclin A2), GeneBank accession No. CR933728 (CDC2, Cell division cycle 2, G1 to S and G2 to M), GeneBank accession No. NM_000919 (PAM, Peptidylglycine alpha-amidating monooxygenase), GeneBank accession No. NM_001790 (CDC25C, Cell division cycle 2 5C), GeneBank accession No. NM_001798 (CDK2, Cyclin-dependent kinase 2), GeneBank accession No. NM_001813 (CENPE, Centromere protein E, 312kDa), GeneBank accession No. NM_003318 (TTK, TTK protein kinase), GeneBank accession No. NM_003981 (PRC1, Protein regulator of cytokinesis 1), GeneBank accession No. NM_004523 (KIF11, Kinesin family member 11) GeneBank accession No. NM_004701 (CCNB2, Cyclin B2), GeneBank accession No. NM_005983 (SKP2, S-phase kinase-associated protein 2 (p45)), GeneBank accession No. NM_006101 (KNTC2, Kinetochore associated 2), GeneBank accession No. NM_006845 (KIF2C, Kinesin family member 2C), GeneBank accession No. NM_007375 (TARDBP, TAR DNA binding protein), Gene Registration number (GeneBank accession No.) NM_012112 (TPX2, TPX2, microtubul e-associated, homolog (Xenopus laevis)), GeneBank accession No. NM_014750 (DLG7, Discs, large homolog 7 (Drosophila)), GeneBank accession No. NM_015097 (CLASP2, Cytoplasmic linker associated protein 2), GeneBank accession No. NM_016343 (CENPF, Centromere protein F, 350 / 400ka (mitosin)), GeneBank accession No. NM_016426 (GTSE1, G-2 and S-phase expressed 1), Gene Registration Number (GeneBank accession No.) NM_018492 (PBK, PDZ binding kinase), Gene Registration Number (GeneBank accession No.) NM_018685 (ANLN, Anillin, actin binding protein (scraps homolog, Drosophila)), Gene Registration Number GeneBank accession No. NM_020242 (KNSL7, Kinesin family member 15), GeneBank accession No. NM_031966 (CCNB1, Cyclin B1), GeneBank accession No. NM_138555 (KIF23, Kinesin family member 23 ), GeneBank accession No. U65410 (MAD2L1, MAD2 mitotic arrest defi cient-like 1 (yeast)), GeneBank accession No. AB020656 (CYLD, Cylindromatosis (turban tumor syndrome)), GeneBank accession No. AF033122 (SESN1, Sestrin 1), Gene accession number GeneBank accession No. AK074377 (UHRF1, Chromosome 19 open reading frame 31), GeneBank accession No. AK091170 (CDKN2C, Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)), Gene accession number (GeneBank accession No.) AK094323 (NFYC, Nuclear transcription factor Y, gamma), GeneBank accession No. AY366508 (LOH11CR2A, Loss of heterozygosity, 11, chromosomal region 2, gene A), GeneBank accession No. BC033086 (TCF19, Transcription factor 19 (SC1)), GeneBank accession No. BC040303 (PTP4A1, Protein tyrosine phosphatase type IVA, member 1), GeneBank accession No. BC040991 (TFDP2, Transcription factor Dp-2 (E2F dimerization partner 2), gene registration number (GeneBank accession No.) BC092412 (SGOL2, Shugoshin-like 2 (S. pombe), GeneBank accession No. BQ278454 (CKS1B, CDC28 protein kinase regulatory subunit 1B), GeneBank accession No. BX649128 (SESN3, Sestrin 3), GeneBank accession No. ) CD049340 (AURKB, Aurora kinase B), GeneBank accession No. M89914 (NF1, Neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)), GeneBank accession No. NM_001005414 (ZWINT, ZW10 interactor antisense), GeneBank accession No. NM_001008491 (Sep 2, Septin 2), GeneBank accession No. NM_001274 (CHEK1, CHK1 checkpoint homolog (S. pombe)), gene registration number GeneBank accession No.NM_002105 (H2AFX, H2A histone family, member X), GeneBank accession No.NM_002388 (MCM3, MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)), Gene accession number (GeneBank accession No. NM_002417 (MKI67, Antigen identified by monoclon al antibody Ki-67), GeneBank accession No. NM_002875 (RAD51, RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)), GeneBank accession No. NM_003884 (PCAF, P300 / CBP-associated factor), GeneBank accession No. NM_004526 (MCM2, MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)), GeneBank accession No. NM_004847 (AIF1, Allograft inflammatory factor 1), GeneBank accession No. NM_005915 (MCM6, MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) ( S. cerevisiae)), GeneBank accession No. NM_012090 (MACF1, Microtubule-actin crosslinking factor 1), GeneBank accession No. NM_012415 (RAD54B, RAD54 homolog B (S. cerevisiae)), GeneBank accession No. NM_014264 (PLK4, Polo-like kinase 4 (Drosophila)), GeneBank accession No. NM_015714 (G0S2, G0 / G1switch 2), GeneBank accession No. NM_024680 (FLJ23311, E2F transcription factor 8), GeneBank accession No. XM_034274 (MYBL1, V-myb myeloblastosis viral oncogene homolog (avian) -like 1), GeneBank accession No. AK001720 ( FLJ10858, Nei endonuclease VIII-like 3 (E. coli)), gene registration number (GeneBank acc ession No.) AY032677 (POLQ, Polymerase (DNA directed), theta), GeneBank accession No. BC034480 (BLM, Bloom syndrome), GeneBank accession No. BC073161 (RAD51C, RAD51 homolog C (S. cerevisiae)), GeneBank accession No. CR600021 (HMGB2, High-mobility group box 2), GeneBank accession No. CR625391 (RAD51AP1, RAD51 associated protein 1), GeneBank accession No.) CR936783 (FLJ40869, Hypothetical protein LOC284952), GeneBank accession No. DQ140356 (KIAA1596, Fanconi anemia, complementation group M), GeneBank accession No. NM_001067 (TOP2A, Topoisomerase (DNA) II alpha 170kDa), GeneBank accession No. NM_001618 (PARP1, Poly (ADP-ribose) polymerase family, member 1), GeneBank accession No. NM_003362 (UNG, Uracil-DNA glycosylase), GeneBank accession No. NM_006904 (PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), GeneBank accession No. NM_130398 (EXO1, Exonuclease 1), GeneBank accession No. AB020807 (TLR6, Toll-like receptor 6), gene GeneBank accession No. AB032980 (DCDC2, Doublecortin domain containing 2), GeneBank accession No. AB209866 (TFPI, Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)), GeneBank accession No.) AK057015 (HSPA4, Heat shock 70kDa protein 4), GeneBank accession No. AK095515 (IFIT1, Interferon-induced protein with tetratricopeptide repeats 1), GeneBank accession No. AK122686 (IF, I factor (complement), GeneBank accession No. AK123010 (RRM2, Ribonucleotide reductase M2 polypeptide), GeneBank accession No. BC035582 (TRIM22, Tripartite motif-containing 22), Gene accession number ( GeneBank accession No. BX537894 (LOC493869, Similar to RIKEN cDNA 2310016C16), GeneBank accession No. M14338 (PROS1, Protein S (alpha)), GeneBank accession No. NM_000821 (GGCX, Gamma -glutamyl carboxyla se), GeneBank accession No. NM_000963 (PTGS2, Prostaglandin-endoperoxide synthase 2 (prostaglandin G / H synthase and cyclooxygenase)), GeneBank accession No. NM_001001547 (CD36, CD36 antigen (collagen type) I receptor, thrombospondin receptor), GeneBank accession No. NM_001512 (GSTA4, Glutathione S-transferase A4), GeneBank accession No. NM_001629 (ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), GeneBank accession No. NM_001752 (CAT, Catalase), GeneBank accession No. NM_001837 (CCR3, Chemokine (CC motif) receptor 3), GeneBank accession No. NM_001979 (EPHX2 , Epoxide hydrolase 2, cytoplasmic), GeneBank accession No. NM_001994 (F13B, Coagulation factor XIII, B polypeptide), GeneBank accession No. NM_002182 (IL1RAP, Interleukin 1 receptor accessory protein), gene Registration number GeneBank accession No. NM_006120 (HLA-DMA, Major histocompatibility complex, class II, DM alpha), GeneBank accession No. NM_173216 (SIAT1, ST6 beta-galactosamide alpha-2,6-sylyltranferase 1), GeneBank accession No. NM_202002 (FOXM1, Forkhead box M1), GeneBank accession No. AB163917 (LRAP, Leukocyte-derived arginine aminopeptidase), GeneBank accession No. BC027881 (AFP) , Alpha-fetoprotein, GeneBank accession No. NM_015915 (SPG3A, Spastic paraplegia 3A (autosomal dominant)), GeneBank accession No. NM_000671 (ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), GeneBank accession No. J05428 (UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), GeneBank accession No. NM_000672 (ADH6, Alcohol dehydrogenase 6 (class V)), gene registration number (GeneBank accession No.) M15943 (ADH4, Alcohol dehy drogenase 4 (class II), pi polypeptide), gene accession number (GeneBank accession No.) AK223395 (FBP1, Fructose-1,6-bisphosphatase 1), gene accession number (GeneBank accession No.) NM_000151 (G6PC, Glucose-6 -phosphatase, catalytic (glycogen storage disease type I, von Gierke disease), GeneBank accession No. XM_113962 (KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), GeneBank accession No. AB020644 (ACSL6, Acyl-CoA synthetase long-chain family member 6), GeneBank accession No. AB209907 (PLD1, Phospholipase D1, phophatidylcholine-specific), GeneBank accession No. AF285167 (ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1), GeneBank accession No. AF297872 (TRERF1, Transcriptional regulating factor 1), GeneBank accession No. AF303134 (ALDH8A1, Aldehyde) dehydrogenase 8 family, member A1), gene registration number GeneBank accession No.AF339053 (PLA2G12B, Phospholipase A2, group XIIB), GeneBank accession No.AK096018 (HADHSC, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain), Gene accession number (GeneBank accession No.) AK124635 (PCSK9, Proprotein convertase subtilisin / kexin type 9), GeneBank accession No. AK127346 (SIAT9, ST3 beta-galactoside alpha-2,3-sialyltransferase 5), GeneBank accession No. AL359559 (AGPS, Alkylglycerone phosphate synthase), GeneBank accession No. AY691170 (PLCL3, Phospholipase C-like 3), GeneBank accession No. BG567934 (APOM, Apolipoprotein M), Gene Registration Number (GeneBank accession No.) BX538214 (C6orf167, Chromosome 6 open reading frame 167), GeneBank accession No. BX640945 (FADS2, Fatty acid desaturase 2), Gene accession number BX648473 ( PIGK, Phosphatidylinositol glycan, class K), gene registration GeneBank accession No. BX648557 (HSD17B2, Hydroxysteroid (17-beta) dehydrogenase 2), GeneBank accession No. CR749601 (ETNK1, Death-associated protein kinase 3), Gene accession No. ) NM_000859 (HMGCR, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase), GeneBank accession No. NM_001443 (FABP1, Fatty acid binding protein 1, liver), GeneBank accession No. NM_002130 (HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble), GeneBank accession No.) NM_003725 (RODH, Hydroxysteroid (17-beta) dehydrogenase 6), Gene accession number (GeneBank accession No NM_004845 (PCYT1B, Phosphate cytidylyltransferase 1, choline, beta), GeneBank accession No. NM_014762 (DHCR24, 24-dehydrocholesterol reductase), GeneBank accession No. NM_020139 (DHRS6ductase) (SDR family) member 6), GeneBank accessi on No.) NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), GeneBank accession No. NM_032523 (OSBPL6, Oxysterol binding protein-like 6), GeneBank accession No. NM_033505 ( SELI, Selenoprotein I), GeneBank accession No. Z28339 (AKR1D1, Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)), GeneBank accession No.) AK024899 (ENPP3, Ectonucleotide pyrophosphatase / phosphodiesterase 3), GeneBank accession No. AK025546 (PTPN4, Protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)), Gene Accession No. AK124910 (ENPP2, Ectonucleotide pyrophosphatase / phosphodiesterase 2 (autotaxin)), gene accession number (GeneBank accession No.) BC035116 (FLJ35059 fis, CDNA FLJ30761 fis, clone FEBRA2000538), gene accession number (GeneBank accession No.) BC050565 (PASK, PAS domain containing serine / threonine kinase), GeneBank accession No. L13436 (NPR2, Natriuretic peptide receptor B / guanylate cyclase B (atrionatriuretic peptide receptor B)), GeneBank accession No. NM_001005862 (ERBB2, V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro / glioblastoma derived oncogene homolog (avian), GeneBank accession No. NM_005012 (ROR1, Receptor tyrosine kinase-like orphan receptor 1), GeneBank accession No. NM_006035 (CDC42BPB , CDC42 binding protein kinase beta (DMPK-like), GeneBank accession No. NM_014791 (MELK, Maternal embryonic leucine zipper kinase), GeneBank accession No. NM_023028 (FGFR2, Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer yndrome, Jackson-Weiss syndrome)), GeneBank accession No. NM_080836 (STK35, Serine / threonine kinas) e 35), GeneBank accession No. AF419331 (FUSIP1, FUS interacting protein (serine / arginine-rich) 1), GeneBank accession No. AK091927 (SFRS3, Splicing factor, arginine / serine- rich 3), GeneBank accession No. BC010266 (HNRNPA1, Heterogeneous nuclear ribonucleoprotein A1), GeneBank accession No. BC012360 (CTAGE5, CTAGE family, member 5), GeneBank accession No. BC036046 (PLRG1, Pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)), GeneBank accession No. BC065384 (PCF11, PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)), GeneBank accession No. BX537360 (CPSF5, Nudix (nucleoside diphosphate linked moiety X) -type motif 21), GeneBank accession No. BX537494 (HNRPA2B1, Heterogeneous nuclear ribonucleoprotein A2 / B1 GeneBank accession No. BX647784 (HNRPR, Heterogeneous nuclear ribonucleoprotein R), GeneBank accession No. CA455267 (PPIH, Peptidyl prolyl isomerase H (cyclophilin H), GeneBank accession No.) CR596214 (HNRPA0, Heterogeneous nuclear ribonucleoprotein A0), GeneBank accession No. NM_001326 (CSTF3, Hypothetical protein LOC283267), GeneBank accession No. NM_004640 (BAT1, HLA-B associated transcript 1 GeneBank accession No. NM_005463 (HNRPDL, Heterogeneous nuclear ribonucleoprotein D-like), GeneBank accession No. NM_006924 (SFRS1, Splicing factor, arginine / serine-rich 1 (splicing fact) or 2, alternate splicing factor), GeneBank accession No. NM_012426 (SF3B3, Splicing factor 3b, subunit 3, 130 kDa), GeneBank accession No. NM_018048 (FLJ10292, Mago-nashi homolog) , GeneBank accession No. NM_030919 (C20orf129, Chromosome 20 open reading frame 129), GeneBank accession No. NM_031370 (HNRPD, Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) GeneBank accession No. NM_138933 (ACF, Apobec-1 complementation factor), GeneBank accession No. AB193259 (ACE2, Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2), gene GeneBank accession No. BX648769 (EWSR1, Ewing sarcoma breakpoint region 1), GeneBank accession No. AB023154 (DTX4, Deltex 4 homolog (Drosophila)), GeneBank accession No. AL543755 (VAV3, Vav 3 oncogene), gene registration number ( GeneBank accession No.) M75106 (CPB2, Carboxypeptidase B2 (plasma, carboxypeptidase U)), gene accession number (GeneBank accession No.) NM_021045 (ZNF248, Zinc finger protein 248), gene accession number (GeneBank accession No.) AB209194 (B4GALT6 , UDP-Gal: betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6), gene accession number (GeneBank accession No.) AF279145 (ANTXR1, Anthrax toxin receptor 1), gene accession number (GeneBank accession No.) NM_025074 (FRAS1, Fraser syndrome 1), gene accession number (GeneBank accession No.) AK025790 (KIF20A, Kinesin family member 20A), gene accession number (GeneBank accession No.) NM_006152 (LRMP, Lymphoid-restricted membrane protein), gene accession number (GeneBank accession No. NM_000340 (SLC2A2, Solute carrier family 2 (facilitated glucose transporter), member 2), GeneBank accession No. AF071592 (KIF4A, Kinesin family member 4A), GeneBank accession No. NM_013277 ( RACGAP1, Rac GTPase activating protein 1), GeneBank accession No. AY043484 (SCN1A, Sodium channel, voltage-gated, type I, alpha), GeneBank accession No. AY791349 (KIF18A, Kinesin family member 18A), gene registration Number (GeneBank accession No.) NM_018018 (SLC38A4, Solute carrier family 38, member 4), GeneBank accession No. AK094603 (FLJ37284 fis, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590.), GeneBank accession No. NM_021069 (ARGBP2, Sorbin and SH3 domain containing 2), GeneBank accession No. NM_001005747 (CACNB4, Calcium channel, voltage- dependent, beta 4 subunit), GeneBank accession No. AJ496568 (SLC25A12, Solute carrier family 25 (mitochondrial carrier, Aralar), member 12), GeneBank accession No. NM_030641 (APOL6, Apolipoprotein L , 6), GeneBank accession No. NM_173512 (FLJ39822, Hypothetical protein FLJ39822), GeneBank accession No. NM_000037 (ANK1, Ankyrin 1, erythrocytic), Gene accession number (GeneBank accession No.) NM_001011554 (SLC13A3, Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3), Gene Accession No. , Ankyrin repeat and SOCS box-containing 9), GeneBank accession No. AK055221 (FBXO5, F-box protein 5), GeneBank accession No. AK075271 (SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2 -like (aminotransferase 2)), gene accession number (GeneBank accession No.) AK122685 (GLUD1, Glutamate dehydrogenase 1), gene accession number (GeneBank accession No.) AK127098 (FLJ10706, Chromosome 1 open reading frame 112), gene accession number GeneBank accession No.AL133031 (MLR1, Transcription factor MLR1), GeneBank accession No. AY007723 (MAL2, Mal, T-cell differentiation protein 2), GeneBank accession No. BC022255 (Spc25 Spindle pole body component 25 homolog (S. cerevisiae)), GeneBank accession No. BC041882 (ATF7IP2, Activating transcription factor 7 interacting protein 2), GeneBank accession No. BC052951 (LMNB1, Lamin B1), Gene accession No. BC098313 (FLJ20641, Hypothetical protein FLJ20641), GeneBank accession No. NM_001809 (CENPA, Centromere protein A, 17kDa), GeneBank accession No. NM_145061 (C13orf3, Chromosome 13 open reading frame 3), GeneBank accession No. XM_372695 (LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase (LOC390859), mRNA). Claim 1 DNA microarray chip for confirming the exposure to the oligonucleotide containing all or part of the biomarker gene sequence or phenanthrene integrated with its complementary oligonucleotide. 1) separating RNA from test subject-derived human somatic cells and control somatic cells; 2) labeling the experimental group and the control group with different fluorescent substances while synthesizing RNA of the experimental group and the control group of step 1) with cDNA; 3) hybridizing cDNA labeled with different fluorescent materials of step 2) with DNA microarray chip of claim 4; 4) analyzing the reacted DNA microarray chip of step 3); And 5) The method of detecting the biomarker of claim 1 in order to confirm the exposure to phenanthrene comprising the step of confirming the expression level of the biomarker of claim 1 in the analyzed data of step 4) compared to the control. The method according to claim 5, wherein the human somatic cells of step 1) are cells derived from cells and tissues of human liver or liver cancer, wherein the biomarker of claim 1 is detected to confirm exposure to phenanthrene. . The method of claim 6, wherein the human liver cancer cells are HepG2, the method of detecting the biomarker of claim 1 to determine whether the exposure to phenanthrene. The method of claim 5, wherein the fluorescent material of step 3) is selected from the group consisting of Cy3, Cy5, poly L-lysine-fluorescein isothiocyanate (FITC), rhodamine-B-isothiocyanate (RITC), and rhodamine (rhodamine) Method of detecting the biomarker of claim 1 to determine whether the exposure to phenanthrene. 1) separating RNA from test subject-derived human somatic cells and control somatic cells; 2) performing real-time reverse transcript polymerase chain reaction (RT-PCR) on the RNA of step 1) using a primer pair capable of amplifying the biomarker gene of claim 1; And 3) The method of detecting the biomarker of claim 1 to determine whether the exposure to the phenanthrene comprising the step of comparing the gene product of step 2) with the control to confirm the expression level. 10. The method according to claim 9, wherein the human somatic cells of step 1) are cells derived from cells or tissues of liver or liver cancer, wherein the biomarker of claim 1 is detected to confirm exposure to phenanthrene. The method of claim 10, wherein the human liver cancer cells are HepG2. 12. Claim 4 kit for confirming exposure to phenanthrene comprising the DNA microarray chip of claim 4. The kit for confirming exposure to phenanthrene according to claim 12, further comprising human liver cells or liver cancer cells. Kit for confirming exposure to phenanthrene comprising a primer pair capable of amplifying the biomarker gene of claim 1. The kit for confirming exposure to phenanthrene according to claim 14, wherein the primer pairs are two or more forward and reverse directions selected from the group consisting of sequences represented by SEQ ID NOs: 1 to 56.

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