KR20100017576A - 트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법 - Google Patents

트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법 Download PDF

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KR20100017576A
KR20100017576A KR1020097025187A KR20097025187A KR20100017576A KR 20100017576 A KR20100017576 A KR 20100017576A KR 1020097025187 A KR1020097025187 A KR 1020097025187A KR 20097025187 A KR20097025187 A KR 20097025187A KR 20100017576 A KR20100017576 A KR 20100017576A
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thrombin receptor
thrombin
platelet
trap
particles
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데니스 더빈
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아큐메트릭스, 인크.
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Application filed by 아큐메트릭스, 인크. filed Critical 아큐메트릭스, 인크.
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020097025187A 2007-05-03 2008-05-02 트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법 Ceased KR20100017576A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91582007P 2007-05-03 2007-05-03
US60/915,820 2007-05-03

Related Child Applications (1)

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KR1020157010978A Division KR20150051243A (ko) 2007-05-03 2008-05-02 트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법

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KR20100017576A true KR20100017576A (ko) 2010-02-16

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KR1020097025187A Ceased KR20100017576A (ko) 2007-05-03 2008-05-02 트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법
KR1020157010978A Ceased KR20150051243A (ko) 2007-05-03 2008-05-02 트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법

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KR1020157010978A Ceased KR20150051243A (ko) 2007-05-03 2008-05-02 트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법

Country Status (7)

Country Link
US (1) US20080299587A1 (enExample)
EP (1) EP2153235B1 (enExample)
JP (2) JP5514101B2 (enExample)
KR (2) KR20100017576A (enExample)
CN (1) CN101675342A (enExample)
ES (1) ES2387700T3 (enExample)
WO (1) WO2008137673A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220082858A (ko) * 2019-10-17 2022-06-17 노바 바이오메디컬 코포레이션 응고 검정 장치 및 이의 방법

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE536889T1 (de) 2003-07-08 2011-12-15 Accumetrics Inc Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten
US20070243632A1 (en) * 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
WO2009152094A2 (en) * 2008-06-09 2009-12-17 Accumetrics, Inc. Hubbed dual cannula device for closed container sampling systems
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
EP2371284A1 (en) * 2010-03-24 2011-10-05 C A Casyso AG Method and apparatus for determining at least one evaluation parameter of a blood sample
US10295539B2 (en) 2010-04-19 2019-05-21 Meso Scale Technologies, Llc. Serology assays
CN107389932B (zh) * 2010-09-15 2019-11-22 德比奥法姆国际股份有限公司 用于从含纤维蛋白原的样品中分离目标分子或颗粒的方法
RU2559873C2 (ru) * 2011-04-27 2015-08-20 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Миметики поли (adp-рибозы) и способ их получения
CN103969228A (zh) * 2013-02-04 2014-08-06 百奥泰生物科技(广州)有限公司 一种整合素GP IIb/IIIa特异性结合分子巴替非班的生物学效应检测方法
EP3060233A4 (en) * 2013-10-25 2017-04-12 Bristol-Myers Squibb Company Diagnostic methods for par4 antagonist therapy
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
US10816559B2 (en) 2014-09-29 2020-10-27 Ca Casyso Ag Blood testing system and method
CN105717263B (zh) * 2016-03-04 2018-01-26 北京乐普医疗科技有限责任公司 一种检测噻吩并吡啶类抗血小板药物疗效的试剂卡及其使用方法和应用
CN111788300B (zh) * 2017-12-28 2024-08-13 株式会社钟化 细胞聚集抑制剂
CN109884326B (zh) * 2019-03-27 2022-08-19 深圳优迪生物技术有限公司 血小板聚集功能检测试剂盒
CN110051692A (zh) * 2019-04-12 2019-07-26 南京市第一医院 一种血小板定向释放生长因子的组合物及其制备方法
CN116794333A (zh) * 2022-12-22 2023-09-22 北京乐普诊断科技股份有限公司 一种全面激活血小板基础凝集功能的激活剂配方及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3518057A (en) * 1966-04-22 1970-06-30 Huron Road Hospital Method and apparatus for thrombus formation time determinations
US3694161A (en) * 1971-04-14 1972-09-26 Armour Pharma Method for measuring platelet aggregation
US4051236A (en) * 1973-02-15 1977-09-27 E. R. Squibb & Sons, Inc. Inhibition of blood platelet aggregation
FI58700C (fi) * 1974-02-21 1981-03-10 Braun Melsungen Ag Foerfarande foer maetning av blodplaettars spontanaaggregation i blodplaettsrik citratplasma
CA1284642C (en) * 1986-03-31 1991-06-04 Hikozo Iwakura Prostacyclin (pgi ) analogues
US5066592A (en) * 1988-03-08 1991-11-19 Temple University Of The Commonwealth System Of Higher Education Trigramin - a platelet aggregation inhibiting polypeptide
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5763199A (en) * 1994-09-29 1998-06-09 Mount Sinai School Of Medicine Of The City University Of New York Platelet blockade assay
US6221672B1 (en) * 1996-04-30 2001-04-24 Medtronic, Inc. Method for determining platelet inhibitor response
US6043871A (en) * 1997-03-03 2000-03-28 Brigham Young University System and method for measuring blood platelet function
US5922551A (en) * 1997-03-20 1999-07-13 Accumetrics, Inc. Agglutrimetric platelet binding assays in blood
US6210904B1 (en) * 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
KR20010041418A (ko) * 1998-02-27 2001-05-15 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 프로테아제-활성화되는 수용체 4 및 그것의 사용
AU6690001A (en) * 2000-06-15 2001-12-24 Schering Corp Thrombin receptor antagonists
ES2282304T3 (es) * 2000-11-01 2007-10-16 Astellas Pharma Inc. Procedimiento para seleccionar antiplaquetas.
US6841354B2 (en) * 2000-12-21 2005-01-11 Philadelphia, Health & Education Corporation Screening assay for anti-thrombotic/anti-platelet activity
US7476688B2 (en) * 2001-04-19 2009-01-13 Eisai R&D Management Co., Ltd. Cyclic amidine derivatives
EP1493028A4 (en) * 2001-07-06 2006-06-14 Genentech Inc PHAGEN DISPLAY PRESENTED LIGANDS OF THE PDZ DOMAIN
KR100960170B1 (ko) * 2001-10-18 2010-05-26 쉐링 코포레이션 트롬빈 수용체 길항제로서의 힘바신 동족체
US20050019742A1 (en) * 2002-10-15 2005-01-27 Jennings Lisa K. Methods for assessment of platelet aggregation
ATE536889T1 (de) * 2003-07-08 2011-12-15 Accumetrics Inc Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten
US20070243632A1 (en) * 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
US7595169B2 (en) * 2005-04-27 2009-09-29 Accumetrics, Inc. Method for determining percent platelet aggregation
WO2007007588A1 (ja) * 2005-07-08 2007-01-18 Ono Pharmaceutical Co., Ltd. 平面性を有する環状基を母核とする化合物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220082858A (ko) * 2019-10-17 2022-06-17 노바 바이오메디컬 코포레이션 응고 검정 장치 및 이의 방법

Also Published As

Publication number Publication date
JP5514101B2 (ja) 2014-06-04
ES2387700T3 (es) 2012-09-28
JP2014052388A (ja) 2014-03-20
CN101675342A (zh) 2010-03-17
WO2008137673A1 (en) 2008-11-13
KR20150051243A (ko) 2015-05-11
JP2010526319A (ja) 2010-07-29
US20080299587A1 (en) 2008-12-04
EP2153235A1 (en) 2010-02-17
EP2153235B1 (en) 2012-05-16

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